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oxytocin depression

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https://www.readbyqxmd.com/read/29330007/lost-connections-oxytocin-and-the-neural-physiological-and-behavioral-consequences-of-disrupted-relationships
#1
REVIEW
Tobias T Pohl, Larry J Young, Oliver J Bosch
In humans and rodent animal models, the brain oxytocin system is paramount for facilitating social bonds, from the formation and consequences of early-life parent-infant bonds to adult pair bond relationships. In social species, oxytocin also mediates the positive effects of healthy social bonds on the partners' well-being. However, new evidence suggests that the negative consequences of early neglect or partner loss may be mediated by disruptions in the oxytocin system as well. With a focus on oxytocin and its receptor, we review studies from humans and animal models, i...
January 9, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29324397/serum-levels-of-cortisol-dehydroepiandrosterone-and-oxytocin-in-children-with-attention-deficit-hyperactivity-disorder-combined-presentation-with-and-without-comorbid-conduct-disorder
#2
Ümit Işık, Ayhan Bilgiç, Aysun Toker, Ibrahim Kılınç
The present study aimed to investigate serum cortisol, dehydroepiandrosterone (DHEA), and oxytocin levels of children with attention-deficit/hyperactivity disorder (ADHD) combined presentation and those diagnosed with ADHD combined presentation and coexisting conduct disorder. A total of 74 drug-naive children with ADHD combined presentation alone, 32 children with ADHD combined presentation + conduct disorder, and 42 healthy controls were included. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29279308/conditional-deletion-of-hippocampal-ca2-ca3a-oxytocin-receptors-impairs-the-persistence-of-long-term-social-recognition-memory-in-mice
#3
Yu-Ting Lin, Tsan-Yu Hsieh, Tsung-Chih Tsai, Chien-Chung Chen, Chiung-Chun Huang, Kuei-Sen Hsu
Oxytocin (OXT) receptors (OXTRs) are prominently expressed in hippocampal CA2 and CA3 pyramidal neurons, but little is known about its physiological function. As the functional necessity of hippocampal CA2 for social memory processing, we tested whether CA2 OXTRs may contribute to long-term social recognition memory (SRM) formation. Here, we found that conditional deletion of Oxtr from forebrain (Oxtr-/-) or CA2/CA3a-restricted excitatory neurons in adult male mice impaired the persistence of long-term SRM but had no effect on sociability and preference for social novelty...
December 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29190530/rare-missense-coding-variants-in-oxytocin-receptor-oxtr-in-schizophrenia-cases-are-associated-with-early-trauma-exposure-cognition-and-emotional-processing
#4
Andre B Veras, Mara Getz, Robert C Froemke, Antonio Egidio Nardi, Gilberto Sousa Alves, Julie Walsh-Messinger, Moses V Chao, Thorsten M Kranz, Dolores Malaspina
BACKGROUND: Oxytocin is a peptide hormone that influences the integration of social cognition with behavior and affect regulation. Oxytocin also prominently directs the transition of neuronal GABA neurotransmission from excitatory to inhibitory after birth. The oxytocin receptor (OXTR) is linked to schizophrenia, a heterogeneous syndrome. Relationships of OXTR polymorphisms with specific clinical features could aid in evaluating any role of oxytocin in the pathogenesis of schizophrenia...
February 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29175721/de-masking-oxytocin-deficiency-in-craniopharyngioma-and-assessing-its-link-with-affective-function
#5
Dorothea Gebert, Matthias K Auer, Mareike R Stieg, Martin T Freitag, Madlén Lahne, Johannes Fuss, Katharina Schilbach, Jochen Schopohl, Günter K Stalla, Anna Kopczak
Despite the high prevalence of panhypopituitarism and diabetes insipidus in patients with craniopharyngioma (CP), little is known about the functioning of the neuropeptide oxytocin in these patients. This is of special interest as tumor-associated lesions often impair sites critical for oxytocin production and release, and affective dysfunction in CP links with elsewhere reported prosocial, antidepressant and anxiolytic oxytocin effects. Using a prospective study-design, we tested whether oxytocin is reduced in CP-patients, and whether altered oxytocin levels account for affective and emotional dysfunction...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29168023/oxytocin-and-parenting-behavior-among-impoverished-mothers-with-low-vs-high-early-life-stress
#6
Megan M Julian, Katherine L Rosenblum, Jenalee R Doom, Christy Y Y Leung, Julie C Lumeng, Michelle Gómez Cruz, Delia M Vazquez, Alison L Miller
Recent work suggests that key aspects of sensitive parenting (e.g., warmth, emotional attunement) may be shaped in part by biology, specifically the neuropeptide oxytocin. However, some studies have found that oxytocin may not act in expected ways in higher-risk populations (e.g., those with postnatal depression or borderline personality disorder). This study examined the relation between oxytocin and parenting among mothers with varying levels of early life stress. Forty low-income mothers and their 34- to 48-month-old child participated in this study...
November 22, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29134359/anxiety-depression-and-the-microbiome-a-role-for-gut-peptides
#7
REVIEW
Gilliard Lach, Harriet Schellekens, Timothy G Dinan, John F Cryan
The complex bidirectional communication between the gut and the brain is finely orchestrated by different systems, including the endocrine, immune, autonomic, and enteric nervous systems. Moreover, increasing evidence supports the role of the microbiome and microbiota-derived molecules in regulating such interactions; however, the mechanisms underpinning such effects are only beginning to be resolved. Microbiota-gut peptide interactions are poised to be of great significance in the regulation of gut-brain signaling...
November 13, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29125397/oxytocin-receptor-genotype-and-low-economic-privilege-reverses-ventral-striatum-social-anxiety-association
#8
Marlen Z Gonzalez, Meghan H Puglia, James P Morris, Jessica J Connelly
Oxytocin receptor gene (OXTR) polymorphisms, lower ventral striatum (VS) response to social stimuli, and lower economic privilege have been independently associated with depression and anxiety. However, the interactions between these risk factors are unknown. One hundred and fifty-seven healthy adult participants genotyped for OXTR rs237915 completed a common emotion-matching task during functional magnetic resonance imaging. Past economic privilege and depression and anxiety symptoms were concurrently assessed through validated self-report measures...
November 10, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/29100154/oxytocin-plasma-levels-predict-the-outcome-of-psychotherapy-a-pilot-study-in-chronic-depression
#9
A Jobst, L Sabaß, D Hall, B Brücklmeier, A Buchheim, J Hall, N Sarubin, P Zill, P Falkai, E-L Brakemeier, F Padberg
BACKGROUND: Oxytocin is associated with bonding and social deficits in psychiatric disorders and has also been discussed as a potential therapeutic intervention to augment psychotherapy. The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a specific form of psychotherapy for chronic depression, an illness in which interpersonal deficits play a major role. In this pilot study, we investigated whether Oxytocin plasma levels predict the clinical outcome of chronic depressive patients after CBASP...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29096223/plasma-cortisol-and-oxytocin-levels-predict-help-seeking-intentions-for-depressive-symptoms
#10
Susan Thomas, Theresa Larkin
BACKGROUND: Depressed individuals often refuse or withdraw from help, a phenomenon termed help-negation, which is a risk factor for poor outcomes. Most previous research has investigated psychosocial factors including stigma as causes of low help-seeking intentions for depression, however these do not adequately explain the problem. We hypothesised that because help-negation worsens with symptom severity, it might be linked to important biological changes associated with depression itself...
October 30, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29057276/genetic-correlates-of-spirituality-religion-and-depression-a-study-in-offspring-and-grandchildren-at-high-and-low-familial-risk-for-depression
#11
Micheline R Anderson, Lisa Miller, Priya Wickramaratne, Connie Svob, Zagaa Odgerel, Ruixin Zhao, Myrna M Weissman
RATIONALE: Possible genetic correlates of spirituality and depression have been identified in community samples. We investigate some of the previously identified candidates in a sample of families at both high and low-risk for depression. METHOD: Offspring and grandchildren of individuals at high and low-risk for depression, participating in a multi-wave thirty-year longitudinal study, were assessed for seven SNPS drawn from four single gene candidates associated with systems implicated in both depression and spirituality: Serotonin (5-HT1B and 5-HT2A), Dopamine (DRD2), Oxytocin (OT) and Monoamine Vesicular Transporter (VMAT1)...
March 2017: Spirituality in Clinical Practice
https://www.readbyqxmd.com/read/29033100/oxytocin-receptors-oxtr-and-early-parental-care-an-interaction-that-modulates-psychiatric-disorders
#12
REVIEW
Ilaria Cataldo, Atiqah Azhari, Bruno Lepri, Gianluca Esposito
Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword "OXTR" before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total...
October 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29021442/the-relationship-between-the-serum-oxytocin-levels-disease-activity-the-adls-and-the-qol-in-patients-with-rheumatoid-arthritis
#13
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective To investigate the factors associated with depression, including the serum oxytocin (OXT) levels, disease activity, activities of daily living (ADLs) and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods This study included 42-RA-patients. We measured the following variables before and after 6 months of treatment with biological disease-modifying anti rheumatic drugs (bDMARDs): the baseline characteristics (including age, sex, disease duration, smoking, and body mass index), the doses of prednisolone and methotrexate, the serum level of matrix metalloprotease-3, the erythrocyte sedimentation rate and the C-reactive protein level...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28985964/the-hemoglobin-derived-peptide-lvv-hemorphin-7-evokes-behavioral-effects-mediated-by-oxytocin-receptors
#14
Kellen Rosa da Cruz, Larissa Córdova Turones, Gabriel Camargo-Silva, Karina Pereira Gomes, Michelle Mendanha Mendonça, Pablinny Galdino, Christielly Rodrigues-Silva, Robson Augusto Souza Santos, Elson Alves Costa, Paulo Cesar Ghedini, Danielle Ianzer, Carlos Henrique Xavier
LVV-hemorphin-7 (LVV-h7) is bioactive peptide resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which displays oxytocinase activity. Herein, our aims were to assess whether: i) LVV-h7 modifies centrally organized behavior and cardiovascular responses to stress and ii) mechanisms underlying LVV-h7 effects involve activation of oxytocin (OT) receptors, probably as result of reduction of IRAP proteolytic activity upon OT...
September 28, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28950923/adverse-life-events-psychiatric-history-and-biological-predictors-of-postpartum-depression-in-an-ethnically-diverse-sample-of-postpartum-women
#15
J Guintivano, P F Sullivan, A M Stuebe, T Penders, J Thorp, D R Rubinow, S Meltzer-Brody
BACKGROUND: Race, psychiatric history, and adverse life events have all been independently associated with postpartum depression (PPD). However, the role these play together in Black and Latina women remains inadequately studied. Therefore, we performed a case-control study of PPD, including comprehensive assessments of symptoms and biomarkers, while examining the effects of genetic ancestry. METHODS: We recruited our sample (549 cases, 968 controls) at 6 weeks postpartum from obstetrical clinics in North Carolina...
September 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28945961/postpartum-lactation-mediated-behavioral-outcomes-and-drug-responses-in-a-spontaneous-mouse-model-of-obsessive-compulsive-disorder
#16
Swarup Mitra, McKenzie Mucha, Savanah Owen, Abel Bult-Ito
Using a spontaneous mouse model of obsessive-compulsive disorder (OCD), the current study evaluated the influence of postpartum lactation on the expression of compulsive-like behaviors, SSRI effectiveness, and the putative role of oxytocin and dopamine in mediating these lactation specific behavioral outcomes. Compulsive-like lactating mice were less compulsive-like in nest building and marble burying and showed enhanced responsiveness to fluoxetine (50 mg/kg) in comparison to compulsive-like nonlactating and nulliparous females...
October 5, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28918249/perinatal-depression-and-dna-methylation-of-oxytocin-related-genes-a-study-of-mothers-and-their-children
#17
Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28889022/injection-of-oxytocin-into-paraventricular-nucleus-reverses-depressive-like-behaviors-in-the-postpartum-depression-rat-model
#18
Tong Wang, Cuige Shi, Xiaoxiao Li, Pan Zhang, Bo Liu, Hao Wang, Yongjun Wang, Yutao Yang, Yan Wu, Hui Li, Zhi-Qing David Xu
Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). PPD rats exhibited depressive-like behaviors with significantly longer immobility time, shorter climbing time, and lower sucrose consumption compared to the control rats...
January 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28868757/depression-in-early-adolescence-contributions-from-relational-aggression-and-variation-in-the-oxytocin-receptor-gene
#19
Shauna C Kushner, Kathrin Herzhoff, Suzanne Vrshek-Schallhorn, Jennifer L Tackett
Interpersonal stress arising from relational aggression (RA)-the intentional effort to harm others via rejection and exclusion-may increase risk for depression in youth. Biological vulnerabilities related to the hormone oxytocin, which affects social behavior and stress responses, may exacerbate this risk. In a community sample of 307 youth (52% female; age range = 10-14 years), we tested whether (1) the association between RA and subsequent depressive symptoms was mediated through social problems and (2) a single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (OXTR) moderated this indirect association between RA and depression, where GG homozygotes are predicted to be more sensitive to the effects of social problems than A-allele carriers...
September 4, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28865715/plasma-oxytocin-levels-in-major-depressive-and-bipolar-ii-disorders
#20
Yueh-Ju Lien, Hui Hua Chang, Hsin-Chun Tsai, Yen Kuang Yang, Ru-Band Lu, Po See Chen
Oxytocin may play a role in mood regulation. Research has shown the plasma oxytocin level of patients with bipolar I disorder (BD I) during a manic episode was significantly higher than that of BD I patients of other statuses, and also that of healthy subjects. However, whether or not a difference in the level of oxytocin exists between patients with major depressive disorder (MDD) and those with BD II is unclear. This study aimed to investigate the plasma oxytocin levels in MDD and BD II patients in a depressive episode...
December 2017: Psychiatry Research
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