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oxytocin depression

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https://www.readbyqxmd.com/read/28918249/perinatal-depression-and-dna-methylation-of-oxytocin-related-genes-a-study-of-mothers-and-their-children
#1
Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28889022/injection-of-oxytocin-into-paraventricular-nucleus-reverses-depressive-like-behaviors-in-the-postpartum-depression-rat-model
#2
Tong Wang, Cuige Shi, Xiaoxiao Li, Pan Zhang, Bo Liu, Hao Wang, Yongjun Wang, Yutao Yang, Yan Wu, Hui Li, Zhi-Qing David Xu
Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). PPD rats exhibited depressive-like behaviors with significantly longer immobility time, shorter climbing time, and lower sucrose consumption compared to the control rats...
September 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28868757/depression-in-early-adolescence-contributions-from-relational-aggression-and-variation-in-the-oxytocin-receptor-gene
#3
Shauna C Kushner, Kathrin Herzhoff, Suzanne Vrshek-Schallhorn, Jennifer L Tackett
Interpersonal stress arising from relational aggression (RA)-the intentional effort to harm others via rejection and exclusion-may increase risk for depression in youth. Biological vulnerabilities related to the hormone oxytocin, which affects social behavior and stress responses, may exacerbate this risk. In a community sample of 307 youth (52% female; age range = 10-14 years), we tested whether (1) the association between RA and subsequent depressive symptoms was mediated through social problems and (2) a single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (OXTR) moderated this indirect association between RA and depression, where GG homozygotes are predicted to be more sensitive to the effects of social problems than A-allele carriers...
September 4, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28865715/plasma-oxytocin-levels-in-major-depressive-and-bipolar-ii-disorders
#4
Yueh-Ju Lien, Hui Hua Chang, Hsin-Chun Tsai, Yen Kuang Yang, Ru-Band Lu, Po See Chen
Oxytocin may play a role in mood regulation. Research has shown the plasma oxytocin level of patients with bipolar I disorder (BD I) during a manic episode was significantly higher than that of BD I patients of other statuses, and also that of healthy subjects. However, whether or not a difference in the level of oxytocin exists between patients with major depressive disorder (MDD) and those with BD II is unclear. This study aimed to investigate the plasma oxytocin levels in MDD and BD II patients in a depressive episode...
August 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28837950/meta-analytic-review-of-the-effects-of-a-single-dose-of-intranasal-oxytocin-on-threat-processing-in-humans
#5
REVIEW
Jenni Leppanen, Kah Wee Ng, Youl-Ri Kim, Kate Tchanturia, Janet Treasure
BACKGROUND: Heightened threat sensitivity is a transdiagnostic feature in several psychiatric disorders. The neuropeptide oxytocin has been shown to reduce fear related behaviours and facilitated fear extinction in animals. These findings have led to increasing interest to explore the effects of intranasal oxytocin on threat processing in humans. METHODS: The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234). The clinical groups included were people with borderline personality disorder (BPD), anorexia nervosa, bulimia nervosa, depression, anxiety, and alcohol dependence disorder...
August 17, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28812266/oxytocin-and-social-relationships-from-attachment-to-bond-disruption
#6
Oliver J Bosch, Larry J Young
Social relationships throughout life are vital for well-being and physical and mental health. A significant amount of research in animal models as well as in humans suggests that oxytocin (OT) plays an important role in the development of the capacity to form social bonds, the mediation of the positive aspects of early-life nurturing on adult bonding capacity, and the maintenance of social bonding. Here, we focus on the extensive research on a socially monogamous rodent model organism, the prairie vole (Microtus ochrogaster)...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28749705/associations-between-postpartum-depression-breastfeeding-and-oxytocin-levels-in-latina-mothers
#7
Sandraluz Lara-Cinisomo, Kathryn McKenney, Arianna Di Florio, Samantha Meltzer-Brody
BACKGROUND: Postpartum depression (PPD), often comorbid with anxiety, is the leading medical complication among new mothers. Latinas have elevated risk of PPD, which has been associated with early breastfeeding cessation. Lower plasma oxytocin (OT) levels have also been associated with PPD in non-Latinas. This pilot study explores associations between PPD, anxiety, breastfeeding, and OT in Latinas. MATERIALS AND METHODS: Thirty-four Latinas were enrolled during their third trimester of pregnancy and followed through 8 weeks postpartum...
September 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28715127/increased-aggression-and-lack-of-maternal-behavior-in-dio3-deficient-mice-are-associated-with-abnormalities-in-oxytocin-and-vasopressin-systems
#8
J Patrizia Stohn, M Elena Martinez, Maryam Zafer, Daniela López-Espíndola, Lauren M Keyes, Arturo Hernandez
Thyroid hormones regulate many aspects of brain development and function, and alterations in the levels of thyroid hormone action lead to abnormal anxiety- and depression-like behaviors. A complement of factors in the brain function independently of circulating levels of hormone to strictly controlled local thyroid hormone signaling. A critical factor is the type 3 deiodinase (DIO3), which is located in neurons and protects the brain from excessive thyroid hormone. Here we examined whether a local increase in brain thyroid hormone action secondary to DIO3 deficiency is of consequence for social behaviors...
July 17, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28689067/individual-variation-in-plasma-oxytocin-and-vasopressin-levels-in-relation-to-the-development-of-combat-related-ptsd-in-a-large-military-cohort
#9
Alieke Reijnen, Elbert Geuze, Eric Vermetten
In an attempt to decrease the risk of developing mental health problems after military deployment, it is important to find biological markers to identify those at risk. Oxytocin (OT) and arginine vasopressin (AVP) are potential biomarkers for the development of posttraumatic stress disorder (PTSD) because they are involved in the regulation of stress and anxiety. Therefore, the aim was to examine whether plasma OT (pOT) and AVP (pAVP) levels before and after deployment are biomarkers for the development of posttraumatic stress symptoms over time in addition to other known risk factors...
June 28, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28683833/effectiveness-of-skin-to-skin-contact-versus-care-as-usual-in-mothers-and-their-full-term-infants-study-protocol-for-a-parallel-group-randomized-controlled-trial
#10
Kelly H M Cooijmans, Roseriet Beijers, Anne C Rovers, Carolina de Weerth
BACKGROUND: Twenty-to-forty percent of women experience postpartum depressive symptoms, which can affect both the mother and infant. In preterm infants, daily skin-to-skin contact (SSC) between the mother and her infant has been shown to decrease maternal postpartum depressive symptoms. In full-term infants, only two studies investigated SSC effects on maternal depressive symptoms and found similar results. Research in preterm infants also showed that SSC improves other mental and physical health outcomes of the mother and the infant, and improves the quality of mother-infant relationship...
July 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28654093/an-epigenome-wide-dna-methylation-study-of-ptsd-and-depression-in-world-trade-center-responders
#11
P-F Kuan, M A Waszczuk, R Kotov, C J Marsit, G Guffanti, A Gonzalez, X Yang, K Koenen, E Bromet, B J Luft
Previous epigenome-wide association studies (EWAS) of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to small sample sizes, and measurement and tissue differences. The current two EWA analyses of 473 World Trade Center responders are the largest to date for both PTSD and MDD. These analyses investigated DNA methylation patterns and biological pathways influenced by differentially methylated genes associated with each disorder. Methylation was profiled on blood samples using Illumina 450 K Beadchip...
June 27, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28649672/oxytocin-and-stress-related-disorders-neurobiological-mechanisms-and-treatment-opportunities
#12
Lauren M Sippel, Casey E Allington, Robert H Pietrzak, Ilan Harpaz-Rotem, Linda C Mayes, Miranda Olff
Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social-emotional brain. In this review, we present an overview of evidence supporting OT's utility for treating major depressive disorder and posttraumatic stress disorder. We first discuss endogenous OT, which research suggests is not yet a reliable biomarker of stress-related disorders. Second, we review effects of intranasal (IN) OT on processes relevant to stress-related disorders in healthy populations (anhedonia, reward processing, psychosocial stress reactivity, fear/anxiety, and social behavior) and their neurobiological mechanisms (e...
February 2017: Chronic stress
https://www.readbyqxmd.com/read/28639210/-oxytocin-and-the-mechanisms-of-alcohol-dependence
#13
REVIEW
Till Faehrmann, Gerald Zernig, Sergei Mechtcheriakov
One of the crucial purposes of treating alcohol-dependent patients is to enhance their ability to stay abstinent after detoxification therapy. Anxiety and stress vulnerability are the main factors provoking alcohol craving and relapse. In the first months of abstinence, alcohol-dependent patients frequently show sleep disturbances, irritability and depression, indicating chronic activation of stress pathways. In addition, the loss of confidence in interpersonal interactions results in social withdrawal and reduced willingness to participate in therapeutic programs...
June 21, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28594092/understanding-the-relationship-between-cesarean-birth-and-stress-anxiety-and-depression-after-childbirth-a-nationwide-cohort-study
#14
Hung-Hui Chen, Jerry Cheng-Yen Lai, Shyh-Jou Hwang, Nicole Huang, Yiing-Jenq Chou, Li-Yin Chien
BACKGROUND: Women who undergo cesarean birth might have an increased risk for poor mental health after childbirth, possibly because of maternal and neonatal physical problems, low parental confidence, and decreased levels of oxytocin. However, this relationship remains controversial and requires further examination. The study aimed to examine the effect of cesarean birth on postpartum stress, anxiety, and depression. METHODS: This nationwide population-based cohort study was conducted using the Taiwan National Health Insurance Database...
June 8, 2017: Birth
https://www.readbyqxmd.com/read/28578248/gender-differences-in-social-anxiety-disorder-a-review
#15
REVIEW
Maya Asher, Anu Asnaani, Idan M Aderka
Gender differences in social anxiety disorder (SAD) have not received much empirical attention despite the large body of research on the disorder, and in contrast to significant literature about gender differences in other disorders such as depression or posttraumatic stress disorder. To address this gap, we comprehensively reviewed the literature regarding gender differences in eight domains of SAD: prevalence, clinical presentation, functioning and impairment, comorbidity, course, treatment seeking, physiological arousal, and the oxytocin system...
August 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28573887/relations-between-plasma-oxytocin-depressive-symptoms-and-coping-strategies-in-response-to-a-stressor-the-impact-of-social-support
#16
Opal A McInnis, Robyn J McQuaid, Kimberly Matheson, Hymie Anisman
BACKGROUND: Social support can serve as a protective factor against the negative impacts of stressors and may thereby promote well-being. As well, exogenous administration of oxytocin has been tied to diminished stress responses and might also enhance the effects of social support. METHODS/RESULTS: In the current study, conducted among female undergraduate students (N = 67), higher depressive symptoms were related to lower endorsements of problem-focused coping in response to a psychosocial stressor comprising the Trier Social Stress test (TSST)...
June 2, 2017: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/28499211/oxytocin-receptor-and-g-protein-polymorphisms-in-patients-with-depression-and-separation-anxiety
#17
Barbara Costa, Stefano Pini, David S Baldwin, Derrick Silove, Vijaya Manicavasagar, Marianna Abelli, Fabio Coppedè, Claudia Martini
BACKGROUND: The impact of combined variants of Oxytocin Receptor (OXTR) and G protein β3 subunit genes was investigated in relation to retrospective reports of childhood as well as contemporary adult separation anxiety (SA), based on evidence of a β/γ dimer-mediated signaling for OXTR. METHODS: A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443)...
March 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28472899/rejection-sensitivity-and-multiple-group-memberships-the-moderating-role-of-an-oxytocin-receptor-gene-polymorphism
#18
Robbie Woods, Marc Bedard, Robyn Jane McQuaid, Kim Matheson, Hymie Anisman
Rejection sensitivity is a cognitive-affective processing disposition that has been linked to interpersonal difficulties. In this regard, the neuropeptide hormone, oxytocin, is thought to underlie social cognitions and behaviors that promote social affiliation. A single nucleotide polymorphism (SNP) on the oxytocin receptor gene (OXTR), in which guanine (G) is substituted for adenine (A), has been associated with less support-seeking behaviors. In the current study, among 376 undergraduate students, it was shown that the relationship between rejection sensitivity and depressive symptoms was mediated by multiple group memberships...
May 15, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28472396/chronic-activation-of-hypothalamic-oxytocin-neurons-improves-cardiac-function-during-left-ventricular-hypertrophy-induced-heart-failure
#19
Kara Garrott, Jhansi Dyavanapalli, Edmund Cauley, Mary Kate Dwyer, Sarah Kuzmiak-Glancy, Xin Wang, David Mendelowitz, Matthew W Kay
Aims: A distinctive hallmark of heart failure (HF) is autonomic imbalance, consisting of increased sympathetic activity, and decreased parasympathetic tone. Recent work suggests that activation of hypothalamic oxytocin (OXT) neurons could improve autonomic balance during HF. We hypothesized that a novel method of chronic selective activation of hypothalamic OXT neurons will improve cardiac function and reduce inflammation and fibrosis in a rat model of HF. Methods and results: Two groups of male Sprague-Dawley rats underwent trans-ascending aortic constriction (TAC) to induce left ventricular (LV) hypertrophy that progresses to HF...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28467893/meta-analysis-of-the-effects-of-intranasal-oxytocin-on-interpretation-and-expression-of-emotions
#20
REVIEW
Jenni Leppanen, Kah Wee Ng, Kate Tchanturia, Janet Treasure
Accurate interpretation and appropriate expression of emotions are key aspects of social-cognition. Several mental disorders are characterised by transdiagnostic difficulties in these areas and, recently, there has been increasing interest in exploring the effects of oxytocin on social-emotional functioning. This review consists of 33 studies. Fifteen of the studies included people with autism spectrum disorder, schizophrenia, borderline personality disorder, frontotemporal dementia, anorexia nervosa, bulimia nervosa, post-traumatic stress disorder, depression, and opioid and alcohol dependence...
April 30, 2017: Neuroscience and Biobehavioral Reviews
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