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Ruo-Han Chen, Ke-Ping Chen, Wei Hua, Jing Xu, Lin Chen, Yang-Gang Su, Xi Su, Jian-Gang Zou, Ji Yan, Jing-Feng Wang, Bao-Peng Tang, Mei-Xiang Xiang, Shu Zhang
Background: Cardiac implantable electronic devices (CIEDs) greatly improve survival and life quality of patients. However, there are gender differences regarding both the utilization and benefit of these devices. In this prospective CIED registry, we aim to appraise the gender differences in CIED utilization in China. Methods: Twenty centers from 14 provinces in China were included in our registry study. All patients who underwent a CIED implantation in these twenty centers between Jan 2015 and Dec 2016 were included...
April 2018: Journal of Geriatric Cardiology: JGC
Rakesh Gopinathannair, Henri Roukoz, Adarsh Bhan, Ashwin Ravichandran, Mustafa M Ahmed, Dmitry Familtsev, Geetha Bhat, Jennifer Cowger, Munazzah Abdullah, Chirag Sandesara, Rahul Dhawan, Emma J Birks, Jaimin R Trivedi, Mark S Slaughter
BACKGROUND: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients. METHODS AND RESULTS: Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015...
June 15, 2018: Journal of the American Heart Association
R-D Hofheinz, D Arnold, E Fokas, M Kaufmann, T Hothorn, G Folprecht, R Fietkau, W Hohenberger, M Ghadimi, T Liersch, G G Grabenbauer, R Sauer, C Rödel, U Graeven
Background: The German rectal cancer trial CAO/ARO/AIO-04 has shown a significant benefit in 3-year disease-free survival (DFS) of adding oxaliplatin to a standard preoperative 5-fluorouracil-based chemoradiotherapy (CRT) and adjuvant chemotherapy in patients with locally advanced rectal cancer. The use of oxaliplatin as adjuvant treatment in elderly patients with colon cancer is controversial . We therefore investigated the impact of age on clinical outcome in the CAO/ARO/AIO-04 phase 3 trial...
June 4, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Yitschak Biton, Chee Yuan Ng, Xiaojuan Xia, Jayson R Baman, Jean-Philippe Couderc, Arthur J Moss, Valentina Kutyifa, Scott McNitt, Bronislava Polonsky, Wojciech Zareba
INTRODUCTION: Adverse electrical remodeling (AER), represented here as the sum absolute QRST integral (SAI QRST), has previously been shown to be directly associated with the risk for ventricular arrhythmia (VA). Cardiac resynchronization therapy (CRT) is known to reduce the risk for VA through various mechanisms, including reverse remodeling, and we aimed to evaluate the association between baseline AER and the risk for VA in CRT recipients. METHODS AND RESULTS: The study population comprised 961 CRT-D implanted patients from the MADIT CRT study...
May 30, 2018: Journal of Cardiovascular Electrophysiology
Cecilia M Linde, Camilla Normand, Nigussie Bogale, Angelo Auricchio, Maijec Sterlinski, Germanas Marinskis, Christian Sticherling, Alan Bulava, Oscar Perez Cano, Alexander Maas, Klaus K Witte, Roin Rekvava, Salima Abdelali, Kenneth Dickstein
BACKGROUND: To date, there are no data from randomized controlled studies on the benefit of cardiac resynchronization therapy (CRT) when implanted as an upgrade in patients with a previous device as compared to de novo CRT. In the CRT Survey II we compared the baseline data of patients upgraded to CRT (CRT-P/CRT-D) from a previous pacemaker (PM) or implantable cardioverter-defibrillator (ICD) to de novo CRT implantation. METHODS AND RESULTS: In the European CRT Survey II, clinical practice data of patients undergoing CRT and/or ICD implantation across 42 European Society of Cardiology (ESC) countries were collected between October 2015 and December 2016...
May 27, 2018: European Journal of Heart Failure
Alexander P Benz, Mate Vamos, Julia W Erath, Peter Bogyi, Gabor Z Duray, Stefan H Hohnloser
BACKGROUND: Data on preferred ICD lead type and optimal RV lead position in patients undergoing CRT-D implantation are limited. OBJECTIVES: To compare dual- versus single-coil ICD leads and non-apical versus apical RV lead position and their impact on clinical parameters and survival in CRT-D recipients. METHODS: A total of 563 consecutive patients with advanced heart failure and indication for CRT-D implantation were enrolled in two European tertiary centers...
May 24, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
D I Lebedev, S V Popov, A I Mishkina, M V Lebedeva
AIM: To determine the effect of right ventricular myocardial contractility on the response to cardiac resynchronization therapy (CRT). MATERIALS AND METHODS: The study included 80 patients (49 men, mean age 54±10.5) diagnosed with dilated cardiomyopathy, complete left bundle branch block, and the QRS complex width 146 to 240 ms (183±32 ms). Heart failure was NYHA FC III, ejection fraction (EF) - 30.1±3.8 %, 6‑min walk test - 290.5±64.3 m, and end-diastolic volume (EDV) - 220...
2018: Kardiologiia
Y X Zhang, H H Peng, X X Zhang, J D Zhao, W M Wu, J L Wang, D L Huang, L Zong, L W Chen, C Q Liu, M B Liu
Objective: To compare the treatment outcomes for locally advanced hypopharyngeal carcinoma between surgery plus radio(chemo) therapy(SRT) and non-surgery chemoradiotherapy(CRT). Methods: A total of 119 patients diagnosed with advanced hypopharyngeal carcinoma without distant metastases between 2010 and 2014 were identified in the Chinese People's Liberation Army General Hospital, and they were divided into 2 groups: 42 cases in SRT group and 77 cases in CRT group. Patients' clinical information was collected...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Roman Nevzorov, Avital Porter, Shanie Mostov, Shirit Kazum, Alon Eisen, Gustavo Goldenberg, Zaza Iakobishvili, Jairo Kusniec, Gregory Golovchiner, Boris Strasberg, Moti Haim
BACKGROUND: Gender-related differences (GRD) exist in the outcome of patients with cardiac resynchronization therapy (CRT). OBJECTIVES: To assess GRD in patients who underwent CRT. METHODS: A retrospective cohort of 178 patients who were implanted with a CRT in a tertiary center 2005-2009 was analyzed. Primary outcome was 1 year mortality. Secondary endpoints were readmission and complication rates. RESULTS: No statistically significant difference was found in 1 year mortality rates (14...
May 2018: Israel Medical Association Journal: IMAJ
Michael Döring, Micaela Ebert, Nikolaos Dagres, Andreas Müssigbrodt, Kerstin Bode, Helge Knopp, Michael Kühl, Gerhard Hindricks, Sergio Richter
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment option for systolic heart failure, but the benefit of an additional implantable cardioverter-defibrillator (ICD) in elderly patients is not well established. The aim of our study was to evaluate the impact of an additional ICD on survival in elderly CRT recipients. METHODS: Patients aged ≥75 years with an indication for CRT and primary preventive ICD therapy, which underwent implantation of either a CRT-pacemaker (CRT-P) or CRT-defibrillator (CRT-D) were included in the study...
July 15, 2018: International Journal of Cardiology
M H Choi, S N Oh, G E Park, D-M Yeo, S E Jung
PURPOSE: To evaluate the interobserver and intermethod correlations of histogram metrics of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters acquired by multiple readers using the single-section and whole-tumor volume methods. MATERIALS AND METHODS: Four DCE parameters (Ktrans , Kep , Ve , Vp ) were evaluated in 45 patients (31 men and 14 women; mean age, 61±11 years [range, 29-83 years]) with locally advanced rectal cancer using pre-chemoradiotherapy (CRT) MRI...
May 10, 2018: Diagnostic and Interventional Imaging
Szymon Domagała, Michał Domagała, Jakub Chyła, Celina Wojciechowska, Marianna Janion, Anna Polewczyk
In the past years we have been observing the dynamic development of electrotherapy, as evidenced by the steadily rising number of implanted pacemakers (PM), as well as devices used in the treatment of dangerous arrhythmia and heart failure, such as implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy (CRT-P/D). This is a consequence of the ageing of the populations of the majority of developed countries and also the gradually widening indications for the use of such devices. Along with the observed rise in the number of new implantations, the number of complications of electrotherapy is rising as well...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
F P Li, H Wang, J Hou, J Tang, Q Lu, L L Wang, X P Yu
AIM: To investigate the utility of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in predicting the early response to concurrent chemoradiotherapy (CRT) in oesophageal squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Thirty-three patients with OSCC who received CRT underwent IVIM-DWI at three time points (before CRT, at the end of radiotherapy 20 Gy, and immediately after CRT). After CRT, the patients were divided into the responders (complete response or partial response) and the non-responders (stable disease) based on RECIST 1...
May 3, 2018: Clinical Radiology
Khang-Li Looi, Karishma Sidhu, Lisa Cooper, Liane Dawson, Debbie Slipper, Andrew Gavin, Nigel Lever
Background: Implantable cardioverter-defibrillator (ICD) therapy is indicated for selected heart failure patients for the primary prevention of sudden cardiac death. Little is known about the outcomes in patients selected for primary prevention device therapy in the northern region of New Zealand. Method: Heart failure patients with systolic dysfunction who underwent primary prevention ICD/cardiac resynchronization therapy-defibrillator (CRT-D) implantation between January 1, 2007, and June 1, 2015, were included...
February 2018: Journal of Arrhythmia
E Fokas, R Fietkau, A Hartmann, W Hohenberger, R Grützmann, M Ghadimi, T Liersch, P Ströbel, G G Grabenbauer, U Graeven, R-D Hofheinz, C-H Köhne, C Wittekind, R Sauer, M Kaufmann, T Hothorn, C Rödel
BACKGROUND: Surrogate endpoints in rectal cancer after preoperative chemoradiation are lacking as their statistical validation poses major challenges, including confirmation based on large phase 3 trials. We examined the prognostic role and individual-level surrogacy of neoadjuvant rectal (NAR) score that incorporates weighted cT, ypT and ypN categories for disease-free survival (DFS) in 1191 patients with rectal carcinoma treated within the CAO/ARO/AIO-04 phase 3 trial. PATIENTS AND METHODS: Cox regression models adjusted for treatment arm, resection status, and NAR score were used in multivariable analysis...
April 27, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Filip Plesinger, Pavel Jurak, Josef Halamek, Petr Nejedly, Pavel Leinveber, Ivo Viscor, Vlastimil Vondra, Scott McNitt, Bronislava Polonsky, Arthur J Moss, Wojciech Zareba, Jean-Philippe Couderc
BACKGROUND: Although cardiac resynchronization therapy (CRT) is beneficial in heart failure patients with left bundle branch block, 30% of these patients do not respond to the therapy. Identifying these patients before implantation of the device is one of the current challenges in clinical cardiology. METHODS: We verified the diagnostic contribution and an optimized computerized approach to measuring ventricular electrical activation delay (VED) from body surface 12-lead ECGs...
May 2018: Circulation. Arrhythmia and Electrophysiology
Francisco Leyva, Abbasin Zegard, Fraz Umar, Robin James Taylor, Edmund Acquaye, Christopher Gubran, Shajil Chalil, Kiran Patel, Jonathan Panting, Howard Marshall, Tian Qiu
Aims: There is a continuing debate as to whether cardiac resynchronization therapy-defibrillation (CRT-D) is superior to CRT-pacing (CRT-P), particularly in patients with non-ischaemic cardiomyopathy (NICM). We sought to quantify the clinical outcomes after primary prevention of CRT-D and CRT-P and identify whether these differed according to the aetiology of cardiomyopathy. Methods and results: Analyses were undertaken in the total study population of patients treated with CRT-D (n = 551) or CRT-P (n = 999) and in propensity-matched samples...
April 25, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Steven E Schild, Herbert H Pang, Wen Fan, Thomas E Stinchcombe, Everett E Vokes, Suresh S Ramalingam, Jeffrey D Bradley, Karen Kelly, Xiaofei Wang
INTRODUCTION: Concurrent chemoradiotherapy (CRT) is standard therapy for locally advanced NSCLC (LA-NSCLC) patients. This study was performed to examine thoracic radiotherapy (TRT) parameters and their impact on patient survival. METHODS: We collected individual patient data from 3600 LA-NSCLC patients participating in 16 cooperative group trials of concurrent CRT. The primary TRT parameters examined included field design strategy (elective nodal irradiation [ENI] compared to involved-field TRT (IF-TRT)), total dose, and biologically effective dose (BED)...
April 22, 2018: Journal of Thoracic Oncology
A J M Rombouts, N Hugen, R H A Verhoeven, M A G Elferink, P M P Poortmans, I D Nagtegaal, J H W de Wilt
BACKGROUND: In the era of organ preserving strategies in rectal cancer, insight into the efficacy of preoperative therapies is crucial. The goal of the current study was to evaluate and compare tumor response in rectal cancer patients according to their type of preoperative therapy. METHODS: All rectal cancer patients diagnosed between 2005 and 2014, receiving radiation therapy (RT, 5 × 5Gy; N = 764) or chemoradiation therapy (CRT; N = 5070) followed by total mesorectal excision after an interval of 5-15 weeks were retrieved from the nationwide Netherlands Cancer registry...
July 2018: European Journal of Surgical Oncology
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
Background: Whether nonsustained ventricular tachycardia (NSVT) is a marker of increased risk of sustained ventricular tachyarrhythmias (VTAs) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator (CRT-D) for primary prevention. Methods: Among the follow-up data of the Japan cardiac device treatment registry (JCDTR) with an implantation date between January 2011 and August 2015, information regarding a history of NSVT before the CRT-D implantation for primary prevention had been registered in 269 patients...
April 2018: Journal of Arrhythmia
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