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https://www.readbyqxmd.com/read/29457358/crt-survey-ii-a-european-society-of-cardiology-survey-of-cardiac-resynchronisation-therapy-in-11-088-patients-who-is-doing-what-to-whom-and-how
#1
Kenneth Dickstein, Camilla Normand, Angelo Auricchio, Nigussie Bogale, John G Cleland, Anselm K Gitt, Christoph Stellbrink, Stefan D Anker, Gerasimos Filippatos, Maurizio Gasparini, Gerhard Hindricks, Carina Blomström Lundqvist, Piotr Ponikowski, Frank Ruschitzka, Giovanni Luca Botto, Alan Bulava, Gabor Duray, Carsten Israel, Christophe Leclercq, Peter Margitfalvi, Óscar Cano, Chris Plummer, Nedim Umutay Sarigul, Maciej Sterlinski, Cecilia Linde
BACKGROUND: Cardiac resynchronisation therapy (CRT) reduces morbidity and mortality in appropriately selected patients with heart failure and is strongly recommended for such patients by guidelines. A European Society of Cardiology (ESC) CRT survey conducted in 2008-2009 showed considerable variation in guideline adherence and large individual, national and regional differences in patient selection, implantation practice and follow-up. Accordingly, two ESC associations, the European Heart Rhythm Association and the Heart Failure Association, designed a second prospective survey to describe contemporary clinical practice regarding CRT...
February 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#2
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29422952/gender-differences-in-the-use-of-primary-prevention-icds-in-new-zealand-patients-with-heart-failure
#3
Khang-Li Looi, Karishma Sidhu, Lisa Cooper, Liane Dawson, Debbie Slipper, Andrew Gavin, Nigel Lever
Objective: Women have been under-represented in randomised clinical trials for primary prevention implantable cardioverter defibrillators (ICDs), and there are concerns about the efficacy of devices between genders. Our study aimed to investigate gender differences in the use of primary prevention ICD in patients with heart failure from the northern region of New Zealand. Methods: Patients with heart failure with systolic dysfunction who received primary prevention ICD/cardiac resynchronisation therapy-defibrillator (CRT-D) in the northern region of New Zealand from 1 January 2007 to 1 June 2015 were included...
2018: Heart Asia
https://www.readbyqxmd.com/read/29380177/prophylactic-use-of-the-implantable-cardioverter-defibrillator-and-its-effect-on-the-long-term-survival-cardiovascular-and-sudden-cardiac-death-in-nonischemic-cardiomyopathy-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Waqas Javed Siddiqui, Sandeep Aggarwal, Muhammad Rafique, Swaiman Singh, Steven Kutalek, Howard J Eisen
Implantable cardioverter-defibrillator (ICD) has shown to reduce sudden cardiac death and overall mortality in patients with dilated cardiomyopathy. The recently published DANISH trial has shown conflicting outcomes on the long-term survival in patients with prophylactic implantation of ICD in Non-Ischemic Cardiomyopathy (NICM). Two independent reviewers searched MEDLINE, PUBMED, Ovid, CINAHL, clinicaltrials.gov , and Cochrane Registry for randomized control trials (RCT's) comparing ICD to medical treatment (MT)...
January 30, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29369371/clinical-outcomes-after-upgrading-from-pacemakers-to-cardiac-resynchronization-therapy
#5
Francisco Leyva, Abbasin Zegard, Kiran Patel, Jonathan Panting, Howard Marshall, Tian Qiu
BACKGROUND AND AIMS: Right ventricular pacing may lead to heart failure (HF). Upgrades from pacemakers to cardiac resynchronization therapy (CRT) were excluded from most randomized, controlled trials. We sought to determine the long-term outcomes of upgrading from pacemakers to CRT with (CRT-D) or without (CRT-P) defibrillation in patients with no history of sustained ventricular arrhythmias. METHODS AND RESULTS: In this observational study, clinical events were quantified in relation to the type of implant (de novo or upgrade) and device type at upgrade (CRT-P or CRT-D)...
January 25, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29348023/impaired-recovery-of-left-ventricular-function-in-patients-with-cardiomyopathy-and-left-bundle-branch-block
#6
Edward Sze, Zainab Samad, Allison Dunning, Kristen Bova Campbell, Zak Loring, Brett D Atwater, Karen Chiswell, Joseph A Kisslo, Eric J Velazquez, James P Daubert
BACKGROUND: Patients with left bundle branch block (LBBB) often respond to cardiac resynchronization therapy (CRT) with left ventricular ejection fraction (LVEF) improvement. Guideline-directed medical therapy (GDMT), not CRT, is first-line therapy for patients with reduced LVEF with LBBB. However, there are little data on how patients with reduced LVEF and LBBB respond to GDMT. OBJECTIVES: This study examined patients with cardiomyopathy and sought to assess rates of LVEF improvement for patients with LBBB compared to other QRS morphologies...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29315424/cardiac-resynchronization-therapy-in-patients-with-end-stage-hypertrophic-cardiomyopathy
#7
Ammar M Killu, Jae-Yoon Park, Jaskanwal D Sara, David O Hodge, Bernard J Gersh, Rick A Nishimura, Samuel J Asirvatham, Christopher J McLeod
Aims: A dilated/end-stage phase of hypertrophic cardiomyopathy (HCM) is rare but well-recognized. The role for cardiac resynchronization therapy (CRT) in this subset of patients remains unexplored. We aimed to clarify the impact of bi-ventricular pacing CRT in dilated/end-stage HCM. Methods and results: The Mayo Clinic HCM database was interrogated to identify patients with ejection fraction (EF) <50% and CRT. Control subjects were identified in 1:1 manner...
January 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29314085/new-onset-left-bundle-branch-block-associated-idiopathic-nonischemic-cardiomyopathy-and-time-from-diagnosis-to-cardiac-resynchronization-therapy-the-neolith-ii-study
#8
Norman C Wang, Jack Z Li, Evan C Adelstein, Andrew D Althouse, Michael S Sharbaugh, Sandeep K Jain, G Stuart Mendenhall, Alaa A Shalaby, Andrew H Voigt, Samir Saba
BACKGROUND: The optimal timing for cardiac resynchronization therapy (CRT) after diagnosis of new-onset left bundle branch block (LBBB)-associated idiopathic nonischemic cardiomyopathy (NICM) and treatment with guideline-directed medical therapy (GDMT) is unknown. The purpose of this study was to describe relationships between time from diagnosis to CRT and outcomes in new-onset LBBB-associated idiopathic NICM with LVEF ≤35%. METHODS: A retrospective cohort study examined associations between time from diagnosis to CRT (≤9 months versus > 9 months) and clinical and echocardiographic outcomes...
January 4, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29306498/concurrent-chemoradiotherapy-for-bladder-cancer-practice-patterns-and-outcomes-in-the-general-population
#9
Ketan Ghate, Kelly Brennan, Safiya Karim, D Robert Siemens, William J Mackillop, Christopher M Booth
BACKGROUND: Clinical trials have shown that chemoradiotherapy (CRT) improves survival compared to radiation therapy (RT) alone in muscle-invasive bladder cancer. We describe uptake of CRT and comparative effectiveness in routine practice. METHODS: Electronic treatment records were linked to the population-based Ontario Cancer Registry to identify all patients with bladder cancer treated with curative-intent RT in 1999-2013. Modified Poisson regression was used to analyze factors associated with use of CRT...
January 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29297204/role-of-intravoxel-incoherent-motion-mri-in-early-assessment-of-the-response-of-esophageal-squamous-cell-carcinoma-to-chemoradiotherapy-a-pilot-study
#10
Huanhuan Zheng, Wei Ren, Xia Pan, Qinglei Zhang, Baorui Liu, Song Liu, Jian He, Zhengyang Zhou
BACKGROUND: Since definitive concurrent chemoradiotherapy (CRT) is standard therapy for inoperable esophageal squamous cell carcinoma (ESCC), early evaluation of treatment response is crucial for patients and would be useful in assessing response, especially in patients with severe side effects. PURPOSE: To explore the feasibility of intravoxel incoherent motion (IVIM) MRI in the early assessment of treatment response to CRT. STUDY TYPE: Prospective...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29295882/chemoradiotherapy-versus-chemotherapy-alone-for-unresected-nonmetastatic-gallbladder-cancer-national-practice-patterns-and-outcomes
#11
Vivek Verma, Swati M Surkar, Eric D Brooks, Charles B Simone, Chi Lin
Purpose: Current guidelines recommend chemotherapy (CT) with or without radiotherapy for unresected nonmetastatic gallbladder cancer (GC), with little consensus. However, several small-volume, single-institution studies have documented the efficacy of local therapy for this population. This is the largest study to date evaluating outcomes of chemoradiotherapy (CRT) versus CT alone in unresected nonmetastatic GC. Methods: The National Cancer Database was queried for primary GC cases (2004-2013) receiving CT alone or CRT...
January 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29280461/comparative-outcomes-after-definitive-chemoradiotherapy-using-proton-beam-therapy-versus-intensity-modulated-radiation-therapy-for-esophageal-cancer-a-retrospective-single-institutional-analysis
#12
Mian Xi, Cai Xu, Zhongxing Liao, Joe Y Chang, Daniel R Gomez, Melenda Jeter, James D Cox, Ritsuko Komaki, Reza Mehran, Mariela A Blum, Wayne L Hofstetter, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Jaffer A Ajani, Steven H Lin
PURPOSE: To compare clinical outcomes between proton beam therapy (PBT) and intensity modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT). METHODS AND MATERIALS: From 2007 through 2014, 343 EC patients who received definitive CRT with either PBT (n=132) or IMRT (n=211) were retrospectively analyzed. Survival, recurrence, and treatment toxicity were compared between groups. A Cox proportional hazards regression model was performed to test the association between patient/treatment variables and survival...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29278718/a-randomised-controlled-trial-of-manualized-cognitive-remediation-therapy-in-adult-obesity
#13
Jayanthi Raman, Phillipa Hay, Kate Tchanturia, Evelyn Smith
OBJECTIVE: Research has indicated that individuals with obesity have neurocognitive deficits, especially in cognitive flexibility that may in turn impact on their weight loss and maintenance. Consequently, we examined the efficacy of a manualised face-to-face cognitive remediation therapy for obesity (CRT-O) within a randomised controlled trial, in terms of improving cognitive flexibility, reducing binge eating behavior, improving quality of life and helping with weight loss. METHODS: 80 adults with obesity (body mass index >30 kg/m2), 70% binge eaters, received three weekly sessions of group Behavioural Weight Loss (BWL) and then were randomised to 8 sessions of individual CRT-O or to a no-treatment control group...
December 23, 2017: Appetite
https://www.readbyqxmd.com/read/29277687/defibrillator-shocks-and-their-impact-on-objective-and-subjective-patient-outcomes-results-from-the-painfree-sst-clinical-trial
#14
Samuel F Sears, Lindsey Rosman, Shingo Sasaki, Yusuke Kondo, Laurence D Sterns, Edward J Schloss, Takashi Kurita, Albert Meijer, Judith Raijmakers, Bart Gerritse, Angelo Auricchio
BACKGROUND: The impact of ICD shock on device-measured activity and patient reported outcomes is unknown. OBJECTIVE: The purpose of this study was to analyze the acute and long-term effects of ICD shock on objective behavioral data (i.e., device-based physical activity) and subjective patient reported outcomes (e.g., quality of life and shock anxiety). METHODS: The PainFree SST clinical trial included 2,770 patients with a single or dual-chamber ICD, or cardiac resynchronization defibrillator (CRT-D) who were followed for 22 ± 9 months...
December 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29275593/-impact-on-the-incidence-of-postoperative-ventricular-arrhythmias-after-cardiac-resynchronization-therapy-defibrillator-with-quadripolar-lead
#15
G H Wu, K Y Chen, F Yu, Q Wang, J Xu, H Su, D M Yang, J Yan
Objective: To evaluate incidence of postoperative ventricular arrhythmias in patients who received cardiac resynchronization therapy defibrillator (CRT-D ) with left ventricular quadripolar lead. Methods: The patients received CRT-D who had complete follow-up data in Anhui Provincial Hospital from June 2013 to June 2016 were included and divided into quadripolar lead group and bipolar lead group according to the type of left ventricular lead. And ventricular arrhythmia (VA), implantable cardioverter-defibrillator (ICD) shocks treatment, antitachycardia pacing therapy (ATP), and other indicators of the two groups were compared...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29274032/impact-of-quadripolar-lv-leads-on-heart-failure-hospitalization-rates-among-patients-implanted-with-crt-d-data-from-the-israeli-icd-registry
#16
Eran Leshem, Mahmoud Suleiman, Avishag Laish-Farkash, Moti Haim, Michael Geist, David Luria, Michael Glikson, Ilan Goldenberg, Yoav Michowitz
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment for heart failure (HF); however, a third of patients are non-responders. The development of quadripolar left ventricular (LV) lead was shown, mainly in single manufactures' registry, to improve LV remodeling and overall mortality. However, limited reports exist on the impact of quadripolar LV leads on HF hospitalization rates in real-life cohorts. We evaluated the clinical outcomes associated with quadripolar LV leads in a large nation-wide registry including all patients implanted with a cardiac resynchronization therapy with defibrillator (CRT-D)...
December 23, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29249433/does-presence-of-left-ventricular-contractile-reserve-improve-response-to-cardiac-resynchronization-therapy-an-updated-meta-analysis
#17
Nikolaos Papageorgiou, Rui Providência, Pier D Lambiase, Dimitris Tousoulis, Guy Lloyd, Sanjeev Bhattacharyya
BACKGROUND: Up to a third of patients undergoing cardiac resynchronization therapy (CRT) do not have a clinical or echocardiographic response. It is also unclear, whether contractile reserve (CR) could predict CRT response. This meta-analysis examines whether the presence of CR improves response to CRT and whether this is modulated by other clinical factors. METHODS: Search of PubMed/EMBASE/Cochrane databases for articles examining response to CRT stratified by the presence or not of CR...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29205287/is-less-more-comparing-chemotherapy-alone-with-chemotherapy-and-radiation-for-high-risk-grade-2-glioma-an-analysis-of-the-national-cancer-data-base
#18
Jaymin Jhaveri, Yuan Liu, Mudit Chowdhary, Zachary S Buchwald, Theresa W Gillespie, Jeffrey J Olson, Alfredo D Voloschin, Bree R Eaton, Hui-Kuo G Shu, Ian R Crocker, Walter J Curran, Kirtesh R Patel
BACKGROUND: The addition of chemotherapy to adjuvant radiotherapy (chemotherapy and radiation therapy [CRT]) improves overall survival (OS) for patients with high-risk grade 2 gliomas; however, the impact of chemotherapy alone (CA) is unknown. This study compares the OS of patients with high-risk grade 2 gliomas treated with CA versus CRT. METHODS: Patients with high-risk grade 2 gliomas (subtotal resection or age ≥ 40 years) with oligodendrogliomas, astrocytomas, or mixed tumors were identified with the National Cancer Data Base...
December 4, 2017: Cancer
https://www.readbyqxmd.com/read/29199680/actual-gains-in-dosimetry-and-treatment-delivery-efficiency-from-volumetric-modulated-arc-radiotherapy-for-inoperable-locally-advanced-lung-cancer-over-five-field-forward-planned-intensity-modulated-radiotherapy
#19
R K Shrimali, M Arunsingh, G D Reddy, S Mandal, B Arun, S Prasath, S Sinha, I Mallick, R Achari, S Chatterjee
AIMS: Volumetric modulated arc radiotherapy (VMAT) is used for inoperable, locally advanced nonsmall cell lung cancer, where three-dimensional conformal radiotherapy (3D-CRT) cannot yield an acceptable plan. METHODS: The planning and treatment data were prospectively collected on the first 18 patients treated using VMAT plans. We analyzed the actual dosimetric gain and impact on treatment, compared with complex multisegment 3D-CRT (five-field forward-planned intensity-modulated radiotherapy [IMRT]) that were generated for treatment...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199448/exploring-the-moderating-effects-of-cognitive-abilities-on-social-competence-intervention-outcomes
#20
Janine P Stichter, Melissa J Herzog, Stephen P Kilgus, Alexander M Schoemann
Many populations served by special education, including those identified with autism, emotional impairments, or students identified as not ready to learn, experience social competence deficits. The Social Competence Intervention-Adolescents' (SCI-A) methods, content, and materials were designed to be maximally pertinent and applicable to the social competence needs of early adolescents (i.e., age 11-14 years) identified as having scholastic potential but experiencing significant social competence deficits. Given the importance of establishing intervention efficacy, the current paper highlights the results from a four-year cluster randomized trial (CRT) to examine the efficacy of SCI-A (n = 146 students) relative to Business As Usual (n = 123 students) school-based programming...
January 2018: Behavior Modification
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