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https://www.readbyqxmd.com/read/29678303/tumor-response-after-long-interval-comparing-5x5gy-radiation-therapy-with-chemoradiation-therapy-in-rectal-cancer-patients
#1
A J M Rombouts, N Hugen, R H A Verhoeven, M A G Elferink, P M P Poortmans, I D Nagtegaal, J H W de Wilt
BACKGROUND: In the era of organ preserving strategies in rectal cancer, insight into the efficacy of preoperative therapies is crucial. The goal of the current study was to evaluate and compare tumor response in rectal cancer patients according to their type of preoperative therapy. METHODS: All rectal cancer patients diagnosed between 2005 and 2014, receiving radiation therapy (RT, 5 × 5Gy; N = 764) or chemoradiation therapy (CRT; N = 5070) followed by total mesorectal excision after an interval of 5-15 weeks were retrieved from the nationwide Netherlands Cancer registry...
March 27, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29657589/prognostic-significance-of-nonsustained-ventricular-tachycardia-in-patients-receiving-cardiac-resynchronization-therapy-for-primary-prevention-analysis-of-the-japan-cardiac-device-treatment-registry-database
#2
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
Background: Whether nonsustained ventricular tachycardia (NSVT) is a marker of increased risk of sustained ventricular tachyarrhythmias (VTAs) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator (CRT-D) for primary prevention. Methods: Among the follow-up data of the Japan cardiac device treatment registry (JCDTR) with an implantation date between January 2011 and August 2015, information regarding a history of NSVT before the CRT-D implantation for primary prevention had been registered in 269 patients...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29656991/model-predicting-the-ypn0-status-after-good-response-to-chemoradiotherapy-in-rectal-cancer
#3
F Dumont, P Dartigues, B Delga, E Thibaudeau, L Benhaim, L Campion, J F Mosnier, J Raimbourg, O Kerdraon, D Goéré
BACKGROUND: The purpose of this study was to identify the predictive factors for ypN0 status in tumors with good pathologic response to chemoradiotherapy (CRT). METHODS: A retrospective chart review was conducted on patients at two tertiary cancer center who underwent rectal resection after good response to CRT between 2000 and 2013. RESULTS: No preoperative treatment (oxaliplatin use, radiotherapy boost of 5,4 Gy, delay CRT-surgery) impacted on the ypN status...
March 31, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29627955/t-wave-positivity-in-lead-avr-is-associated-with-mortality-in-patients-with-cardiac-resynchronization-therapy
#4
Yahya Kemal İçen, Yurdaer Dönmez, Hasan Koca, Mehmet Uğurlu, Mevlüt Koç
PURPOSE: Positive T wave polarity in lead aVR (TPaVR) is associated with a poor prognostic indicator in patients with heart failure reduce ejection fraction (HFrEF). Our aim was to investigate the relationship between positive TPaVR and mortality in patients with cardiac resynchronization therapy defibrillator (CRT-D). METHODS: We included retrospectively 224 HFrEF patients with CRT-D in sinus rhythm. Laboratory, electrocardiographic (ECG), and echocardiographic data were recorded...
April 8, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29625702/comparison-of-long-term-survival-benefits-with-cardiac-resynchronization-therapy-in-patients-with-mild-heart-failure-with-versus-without-diabetes-mellitus-from-the-multicenter-automatic-defibrillator-implantation-trial-with-cardiac-resynchronization-therapy
#5
Valentina Kutyifa, Syed Yaseen Naqvi, Mary Brown, Scott McNitt, Ilan Goldenberg, Helmut Klein, Arthur J Moss
We have previously shown a reduction in HF events with cardiac resynchronization therapy with defibrillator (CRT-D) in patients with mild heart failure (HF) and diabetes mellitus (DM). It remains unknown whether HF remission in DM patients with CRT-D translates into reduced mortality. The effects of CRT-D versus an implantable cardioverter-defibrillator (ICD) alone to reduce long-term mortality were assessed in patients with left bundle branch block with DM (n = 386) and without DM (n = 982), enrolled in the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT)...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29622458/usefulness-of-a-clinical-risk-score-to-predict-the-response-to-cardiac-resynchronization-therapy
#6
Rui Providencia, Eloi Marijon, Sergio Barra, Christian Reitan, Alexander Breitenstein, Pascal Defaye, Nikolaos Papageorgiou, Rudolph Duehmke, Stephan Winnik, Richard Ang, Didier Klug, Daniel Gras, Tardu Oezkartal, Oliver R Segal, Jean-Claude Deharo, Christophe Leclercq, Pier D Lambiase, Laurent Fauchier, Pierre Bordachar, Jan Steffel, Nicolas Sadoul, Olivier Piot, Rasmus Borgquist, Sharad Agarwal, Anthony Chow, Serge Boveda
BACKGROUND: Almost 1/3 of heart failure patients fail to respond to cardiac resynchronization therapy (CRT). A simple clinical score to predict who these patients are at the moment of referral or at time of implant may be of importance for early optimization of their management. METHODS: Observational study. A risk score was derived from factors associated to CRT response. The derivation cohort was composed of 1301 patients implanted with a CRT defibrillator in a multi-center French cohort-study...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29604094/cardiac-resynchronization-therapy-is-associated-with-a-reduction-in-icd-therapies-while-improves-ventricular-function
#7
Enrique Galve, Gerard Oristrell, Gabriel Acosta, Aida Ribera-Solé, Àngel Moya-Mitjans, Ignacio Ferreira-González, Jordi Pérez-Rodon, David García-Dorado
BACKGROUND: Repeated implantable cardioverter-defibrillator (ICD) therapies cause myocardial damage and thus, an increased risk of arrhythmias and mortality. HYPOTHESIS: Cardiac resynchronization therapy-defibrillator (CRT-D) reduces the number of appropriate therapies in patients with left ventricular dysfunction (LVEF < 50%). METHODS: The retrospective study involved 175 consecutive patients (age 64.6±10.4 years, 86.9% men) with reduced LVEF 27...
March 31, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29598954/clinical-outcomes-and-prognostic-factors-in-cisplatin-versus-cetuximab-chemoradiation-for-locally-advanced-p16-positive-oropharyngeal-carcinoma
#8
Christian L Barney, Steve Walston, Pedro Zamora, Erin H Healy, Nicole Nolan, Virginia M Diavolitsis, Anterpreet Neki, Robert Rupert, Panos Savvides, Amit Agrawal, Matthew Old, Enver Ozer, Ricardo Carrau, Stephen Kang, James Rocco, Theodoros Teknos, John C Grecula, Jessica Wobb, Darrion Mitchell, Dukagjin Blakaj, Aashish D Bhatt
OBJECTIVES: Randomized trials evaluating cisplatin versus cetuximab chemoradiation (CRT) for p16+ oropharyngeal cancer (OPC) have yet to report preliminary data. Meanwhile, as a preemptive step toward morbidity reduction, the off-trial use of cetuximab in p16+ patients is increasing, even in those who could potentially tolerate cisplatin. The purpose of this study was to compare the efficacy of cisplatin versus cetuximab CRT in the treatment of p16+ OPC and to identify prognostic factors and predictors of tumor response...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29578202/the-impact-of-the-left-ventricular-pacing-polarity-and-localization-during-cardiac-resynchronization-therapy-on-depolarization-and-repolarization-parameters
#9
Emin Evren Özcan, Ali Öztürk, Erdem Özel, Ömer Senarslan, Bela Merkely, Laszlo Geller
OBJECTIVE: Reversal of myocardial activation sequence during cardiac resynchronization therapy (CRT) may increase the transmural dispersion of repolarization (TDR), which may lead to ventricular arrhythmias. Quadripolar left ventricular (LV) leads offer 10 different pacing configurations. However, little is known about the role of pacing polarity on repolarization patterns. Our study aimed to investigate the impact of LV pacing polarity on depolarization and repolarization parameters in the same substrate in the same patient group...
March 21, 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29572715/right-ventricular-lead-location-right-left-ventricular-lead-interaction-and-long-term-outcomes-in-cardiac-resynchronization-therapy-patients
#10
Usama A Daimee, Helmut U Klein, Michael C Giudici, Wojciech Zareba, Scott McNitt, Bronislava Polonsky, Arthur J Moss, Valentina Kutyifa
BACKGROUND: The effects of right ventricular (RV) lead location and the combination of RV and left ventricular (LV) lead locations on long-term outcomes in patients receiving cardiac resynchronization therapy with defibrillator (CRT-D) are not well understood. METHODS: Our cohort consisted of 743 CRT-D patients from MADIT-CRT. We evaluated long-term death and combined heart failure or death (HF/death) in patients with non-apical RV vs. apical RV leads. We further assessed these long-term outcomes based on the combination of RV and LV leads, termed "RV-LV lead interaction...
March 23, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29571989/neoadjuvant-treatment-followed-by-surgery-versus-definitive-chemoradiation-in-stage-iiia-n2-non-small-cell-lung-cancer-a-multi-institutional-study-by-the-oncologic-group-for-the-study-of-lung-cancer-spanish-radiation-oncology-society
#11
F Couñago, N Rodriguez de Dios, S Montemuiño, J Jové-Teixidó, M Martin, P Calvo-Crespo, M López-Mata, M P Samper-Ots, J L López-Guerra, T García-Cañibano, V Díaz-Díaz, L de Ingunza-Barón, M Murcia-Mejía, P Alcántara, J Corona, M M Puertas, M Chust, M L Couselo, E Del Cerro, J Moradiellos, S Amor, A Varela, I J Thuissard, D Sanz-Rosa, B Taboada
OBJECTIVES: The role of surgery in stage IIIA-N2 non-small cell lung cancer (NSCLC) is an actively debated in oncology. To evaluate the value of surgery in this patient population, we conducted a multi-institutional retrospective study comparing neoadjuvant chemoradiotherapy or chemotherapy plus surgery (CRTS) to definitive chemoradiotherapy (dCRT). MATERIAL AND METHODS: A total of 247 patients with potentially resectable stage T1-T3N2M0 NSCLC treated with either CRTS or dCRT between January 2005 and December 2014 at 15 hospitals in Spain were identified...
April 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29540431/device-complications-with-addition-of-defibrillation-to-cardiac-resynchronisation-therapy-for-primary-prevention
#12
Sérgio Barra, Rui Providência, Serge Boveda, Rudolf Duehmke, Kumar Narayanan, Anthony W Chow, Olivier Piot, Didier Klug, Pascal Defaye, Daniel Gras, Jean-Claude Deharo, Paul Milliez, Antoine Da Costa, Pierre Mondoly, Jorge Gonzalez-Panizo, Christophe Leclercq, Patrick Heck, Munmohan Virdee, Nicolas Sadoul, Jean-Yves Le Heuzey, Eloi Marijon
OBJECTIVE: In patients indicated for cardiac resynchronisation therapy (CRT), the choice between a CRT-pacemaker (CRT-P) versus defibrillator (CRT-D) remains controversial and indications in this setting have not been well delineated. Apart from inappropriate therapies, which are inherent to the presence of a defibrillator, whether adding defibrillator to CRT in the primary prevention setting impacts risk of other acute and late device-related complications has not been well studied and may bear relevance for device selection...
March 14, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29531592/electrocardiographic-parameters-as-predictors-of-response-to-cardiac-resynchronization-therapy
#13
Lidija Poposka, Vladimir Boskov, Dejan Risteski, Jane Taleski, Filip Janusevski, Elizabeta Srbinovska, Ljubica Georgievska-Ismail
INTRODUCTION: Although strict selection criteria are used to select patients for cardiac resynchronisation therapy, up to 30% of patients do not have a positive clinical response. PATIENTS: A total of 102 consecutive patients who had biventricular pacemaker/defibrillator (CRT-P or CRT-D) implanted were enrolled in this prospective observational study. RESULTS: During the average follow-up period of 24.3 months 5 patients died and 17 (16.7%) patients were hospitalised with the symptoms of heart failure; 75 (73...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29526169/factors-associated-with-fatal-outcome-of-children-with-enterovirus-a71-infection-a-case-series
#14
S D Yang, P Q Li, Y G Huang, W Li, L Z Ma, L Wu, N Wang, J M Lu, W Q Chen, Guang-Ming Liu, Y M Xiong, Y L Chen, Ying Zhang
Enterovirus A-71 (EV-A71) may be fatal, but the natural history, symptoms, and signs are poorly understood. This study aimed to examine the natural history of fatal EV-A71 infection and to identify the symptoms and signs of early warning of deterioration. This was a clinical observational study of fatal cases of EV-A71 infection treated at five Chinese hospitals between 1 January 2010 and 31 December 2012. We recorded and analysed 91 manifestations of EV-A71 infection in order to identify early prognosis indicators...
March 12, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29523823/evaluation-of-the-therapeutic-effects-of-quickopt-optimization-in-chinese-patients-with-chronic-heart-failure-treated-by-cardiac-resynchronization
#15
Ji Yan, Shu Zhang, Dejia Huang, Xiaolin Xue, Jing Xu, Qianmin Tao, Weize Zhang, Zheng Zhang, Wei Hua, Yanchun Liang, Baopeng Tang, Wei Xu, Geng Xu, Xuejun Ren, Jingfeng Wang, Tao Guo, Shaobin Jia, Yugang Dong, Hong Jiang, Guosheng Fu, Liguang Zhu, Lin Chen, Fuli Tian, Feng Ling, Jianmei Li, Xiaoyong Qi, Yinglu Hao, Yutang Wang, Liangrong Zheng, Xiaoqun Pu, Farong Shen, Guangping Li, Hui Li, Fang Peng
In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) and interventricular (VV) delay optimizations after cardiac resynchronization therapy (CRT) with pacing (CRT-P) or with pacing and defibrillator (CRT-D) therapy. One hundred and ninety-six subjects (50%) had dilated cardiomyopathy, 108 (27.6%) had ischemic heart disease and 112 (28.6%) were hypertensive and were randomized into QuickOpt (198) or echocardiographic optimization (control) (194) groups at ≤2-weeks post-implantation...
March 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29521312/surface-electrogram-guided-left-ventricular-lead-placement-improves-response-to-cardiac-resynchronization-therapy
#16
Abdulcebbar Şipal, Serdar Bozyel, Müjdat Aktaş, Emir Derviş, Tayyar Akbulut, Onur Argan, Umut Çelikyurt, Dilek Ural, Tayfun Şahin, Ayşen Ağır, Ahmet Vural
OBJECTIVE: Failure to select the optimal left ventricular (LV) segment for lead implantation is one of the most important causes of unresponsiveness to the cardiac resynchronization therapy (CRT). In our study, we aimed to investigate the echocardiographic and clinical benefits of LV lead implantation guided by an intraoperative 12-lead surface electrocardiogram (ECG) in patients with multiple target veins. METHODS: We included 80 [42 (62.5%) male] heart failure patients who successfully underwent CRT defibrillator (CRT-D) implantation...
March 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29518574/proteomic-profiling-of-rectal-cancer-reveals-acid-ceramidase-is-implicated-in-radiation-response
#17
D L Bowden, P A Sutton, M A Wall, P V Jithesh, R E Jenkins, D H Palmer, C E Goldring, J L Parsons, B K Park, N R Kitteringham, D Vimalachandran
BACKGROUND: Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin, with varying response to treatment. This experimental study aimed to identify significantly differentially expressed proteins between patients responding and not responding to CRT, and to validate any proteins of interest. METHODS: Mass spectrometry (with isobaric tagging for relative quantification) analysis of rectal cancers pre- and post-CRT, and at resection...
March 5, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29504626/red-cell-distribution-width-a-new-marker-for-exacerbation-of-heart-failure-in-patients-with-hypothyroidism-following-radioiodine-therapy
#18
Agata Czarnywojtek, Nadia Sawicka-Gutaj, Izabela Miechowicz, Magdalena Borowska, Kosma Woliński, Maria Teresa Płazińska, Ariadna Zybek-Kocik, Ewa Straburzyńska-Migaj, Małgorzata Zgorzalewicz-Stachowiak, Aleksandra Hernik, Ewelina Szczepanek-Parulska, Marek Ruchała
INTRODUCTION: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters...
March 5, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29477975/cardiac-electrical-dyssynchrony-is-accurately-detected-by-noninvasive-electrocardiographic-imaging
#19
Laura R Bear, Peter R Huntjens, Richard Walton, Olivier Bernus, Ruben Coronel, Rémi Dubois
BACKGROUND: Poor identification of electrical dyssynchrony is postulated to be a major factor contributing to the low success rate for cardiac resynchronization therapy (CRT). OBJECTIVE: To evaluate body surface mapping and electrocardiographic imaging (ECGi) to detect electrical dyssynchrony noninvasively. METHODS: Langendorff-perfused pig hearts (n=11) were suspended in a human torso-shaped tank, with LBBB induced through ablation. Recordings were taken simultaneously from a 108-electrode epicardial sock and 128 electrodes embedded in the tank surface during sinus rhythm and ventricular pacing...
February 22, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29477349/long-term-outcomes-of-combined-endoscopic-resection-and-chemoradiotherapy-for-esophageal-squamous-cell-carcinoma-with-submucosal-invasion
#20
Shoichi Yoshimizu, Toshiyuki Yoshio, Akiyoshi Ishiyama, Tomohiro Tsuchida, Yusuke Horiuchi, Masami Omae, Toshiaki Hirasawa, Takao Asari, Keisho Chin, Junko Fujisaki
BACKGROUND: For esophageal squamous cell carcinoma (ESCC) with submucosal (SM) invasion, surgery is the standard treatment. Definitive chemoradiotherapy (D-CRT) is a less invasive alternative option, but sometimes results in locoregional failure. AIM: To examine whether endoscopic resection for primary lesion removal combined with chemoradiotherapy (ER-CRT) reduces locoregional failure rates in cases of ESCC with SM invasion. METHODS: We retrospectively compared clinical outcomes between ER-CRT and D-CRT in patients diagnosed with ESCC with SM invasion between 2003 and 2014...
February 7, 2018: Digestive and Liver Disease
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