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JOURNAL ARTICLE
C Sanghera, D P McClurg, C M Jones
BACKGROUND AND AIM: There has been limited progress made in improving the suboptimal outcomes delivered by conventionally fractionated radiotherapy (RT) for oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC). A greater biological effect may be achieved using hypofractionated RT (HFRT), though the toxicity, tolerability and efficacy of this approach in OAC and OSCC is uncertain. METHODS: A systematic literature review was carried out in accordance with Preferred Reporting Items for Systematic Reviews guidance...
March 18, 2024: Clinical Oncology: a Journal of the Royal College of Radiologists
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JOURNAL ARTICLE
Sebastian Feickert, Niels Christian Ewertsen, Julia Köbe, Thomas Kleemann, Joachim Jehle, Jochen Senges, Matthias Hochadel, Dietrich Andresen, Christoph Stellbrink, Lars Eckardt, Stefan Spitzer, Johannes Brachmann, Hüseyin Ince, Giuseppe D'Ancona
BACKGROUND: Atrial fibrillation (AF) is a cardiac arrhythmia frequently documented in patients requiring implantable cardioverter defibrillators (ICDs) and/or cardiac resynchronization therapy with defibrillator (CRT-D). Patients with diagnosed AF at the point of ICD or CRT-D implantation may have an impaired follow-up outcome. METHODS: The German DEVICE I-II registry is a nationwide prospective multicentre database of patients implanted with ICD and CRT-D with clinical follow-up data...
March 29, 2024: Journal of Thoracic Disease
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JOURNAL ARTICLE
Yoshinari Enomoto, Takanori Ikeda, Keijiro Nakamura, Mahito Noro, Kaoru Sugi, Masao Moroi, Masato Nakamura, Kengo Kusano, Torri Schwartz, Torsten Kayser, Kazutaka Aonuma
BACKGROUND: Despite an increased incidence of chronic heart failure (HF) and sudden cardiac death (SCD), the use of implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy (CRT) is much lower in Japan than in Western countries. The HF Indication and SCD Prevention Trial Japan (HINODE) prospectively assessed the mortality rate, appropriately treated ventricular arrhythmias (VA), and HF in Japanese patients with a higher risk of HF.Methods and Results: HINODE consisted of ICD, CRT-defibrillator (CRT-D), pacing, and non-device treatment cohorts...
April 12, 2024: Circulation Journal: Official Journal of the Japanese Circulation Society
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JOURNAL ARTICLE
Bi Yang, Longqian Liu, Pauline Cho
OBJECTIVE: To compare the effectiveness of myopia control in Chinese children, who had been wearing either orthokeratology (ortho-k) lenses or myopia control spectacles (MCS) for one year. METHODS: Relevant data were retrieved from 212 patients, with baseline myopia of -5.00 to -0.75 D, astigmatism ≤ 1.50 D, who had been undergoing myopia control treatment with either ortho-k (Euclid (OK1) or CRT (OK2)) or MCS (Stellest (MCS1) or DIMS (MCS2)) for at least one year...
April 11, 2024: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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JOURNAL ARTICLE
Dong Wei, Jiong Lyu, Bo Wang, Yong He, Ling Bi
BACKGROUND AND PURPOSE: Hirudin, a potent anticoagulant, is used in traditional Chinese medicine (TCM) to treat thrombotic conditions and prevent postoperative thrombosis. Coagulation-related vascular complications are a common cause of perforator flaps failure. This study explores hirudin's potential to enhance flap growth by mitigating coagulation-related issues. MATERIALS AND METHODS: Patients were divided into GroupⅠ(hirudin group) and GroupⅡ(control)...
April 6, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
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JOURNAL ARTICLE
Sonia Chabrak, Abdeddayem Haggui, Emna Allouche, Sana Ouali, Afef Ben Halima, Slim Kacem, Salma Krichen, Sonia Marrakchi, Wafa Fehri, Mohamed Sami Mourali, Zeineb Jabbari, Manel Ben Halima, Elyes Neffati, Aymen Heraiech, Mehdi Slim, Salem Kachboura, Habib Gamra, Majed Hassine, Sondes Kraiem, Sofien Kammoun, Leila Bezdah, Gouider Jridi, Hatem Bouraoui, Samir Kammoun, Rania Hammami, Rafik Chettaoui, Youssef Ben Ameur, Fares Azaiez, Rami Tlili, Kais Battikh, Hedi Ben Slima, Rim Chrigui, Samia Fazaa, Islem Sanaa, Yassine Ellouz, Mohamed Mosrati, Sami Milouchi, Soumaya Jarmouni, Wacef Ayadi, Malek Akrout, Rabie Razgallah, Wissal Neffati, Meriem Drissa, Selma Charfeddine, Salem Abdessalem, Leila Abid, Lilia Zakhama
BACKGROUND: In Tunisia, the number of cardiac implantable electronic devices (CIEDs) is increasing, owing to the increase in patient life expectancy and expanding indications. Despite their life-saving potential and a significant reduction in population morbidity and mortality, their increased numbers have been associated with the development of multiple early and late complications related to vascular access, pockets, leads, or patient characteristics. OBJECTIVE: The study aims to identify the rate, type, and predictors of complications occurring within the first year after CIED implantation...
April 8, 2024: JMIR Research Protocols
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JOURNAL ARTICLE
Richárd Masszi, Előd-János Zsigmond, Réka Ehrenberger, Caner Turan, Péter Fehérvári, Brigitta Teutsch, Zsolt Molnár, Zsófia Drobni, Hajnalka Vágó, Péter Hegyi, Béla Merkely, Annamária Kosztin
AIMS: Late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance (CMR) can evaluate myocardial scar associated with a higher risk of sudden cardiac death (SCD), which can guide the selection between cardiac resynchronization therapy with or without a defibrillator (CRT-P/CRT-D). Our aim was to investigate the association between LGE and SCD risk in patients with CRT using the LGE-CMR technique. METHODS AND RESULTS: We performed a systematic literature search using four databases...
April 8, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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JOURNAL ARTICLE
Anmol Johal, Ndausung Udongwo, Steven Imburgio, Anton Mararenko, Hira Akhlaq, Sowmya Dandu, Temidayo Abe, Jesus Almendral, Joseph Heaton, Riple Hansalia
INTRODUCTION: COVID-19 drastically impacted the landscape of the United States' medical system. Limited data is available on the nationwide implantation trends in Cardiac Resynchronization Therapy Defibrillator (CRT-D) devices before and during the pandemic. We aimed to explore the impact of the COVID-19 pandemic on CRT-D insertion rates and adverse outcomes related to delays in care. METHODS AND RESULTS: We conducted a retrospective cross-sectional analysis using the National Inpatient Sample database between 2017 and 2020...
April 2024: Journal of Arrhythmia
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JOURNAL ARTICLE
Huei-Tyng Huang, Douglas H Brand, John D Fenwick, Maria A Hawkins
PURPOSE: Adding immune checkpoint blockade (ICB) to concurrent chemoradiotherapy (cCRT) has improved overall survival (OS) for inoperable locally advanced non-small cell lung cancer (LA-NSCLC). Trials of cCRT-ICB are heterogeneous for factors such as tumor stage and histology, PDL1 status and cCRT-ICB schedules. We therefore aimed to determine the ICB contribution to survival across studies and identify factors associated with survival gain. METHODS AND MATERIALS: Data were collated from cCRT-ICB clinical studies published 2018-2022 which treated 2196 NSCLC patients (99% stage III)...
April 1, 2024: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
Cecilia Rorsman, Maiwand Farouq, Sofia Marinko, Pyotr G Platonov, Rasmus Borgquist
Introduction Patients with heart failure (HF) and bradycardia may be eligible for different types of cardiac implantable electronic devices (CIED), depending on presence of AV conduction disease, age and comorbidities. We aimed to assess prognosis for these patients, after CIED implantation, stratified for type of CIED device. Methods All patients with preexisting HF diagnosis who received a CIED with a right ventricular lead during the period 2005-2018 in Sweden were identified via the Pacemaker-registry. Data was crossmatched with the population registry and national disease registries...
March 30, 2024: Cardiology
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JOURNAL ARTICLE
Budhi Singh Yadav, Divya Dahiya, Manish Gupta, Ankita Gupta, Arun S Oinam, Siddhant Khare, Santhosh Irrinki, Ngangom Robert, Yashwant Raj Sakaray, Satish S Nagaraj, Reena Kumari
BACKGROUND: Globally, most of the randomised trials with hypofractionation in patients with breast cancer have used 3-dimensional conformal radiotherapy technique (3D-CRT). As facilities for 3D-CRT technique may not be available in low-resource settings, there is a need to see if hypofractionation is feasible and safe with 2-dimensional (2-D) technique. In this study, we compared a 3-week radiation schedule with a 2-week schedule of hypofractionated radiotherapy in patients with breast cancer with 2-D technique...
May 2024: Lancet Reg Health Southeast Asia
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JOURNAL ARTICLE
Isabel D Friesner, Jean Feng, Shalom Kalnicki, Madhur Garg, Nitin Ohri, Julian C Hong
IMPORTANCE: Toxic effects of concurrent chemoradiotherapy (CRT) can cause treatment interruptions and hospitalizations, reducing treatment efficacy and increasing health care costs. Physical activity monitoring may enable early identification of patients at high risk for hospitalization who may benefit from proactive intervention. OBJECTIVE: To develop and validate machine learning (ML) approaches based on daily step counts collected by wearable devices on prospective trials to predict hospitalizations during CRT...
March 28, 2024: JAMA Oncology
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JOURNAL ARTICLE
Tardu Özkartal, Andrea Demarchi, Giulio Conte, Damiano Pongan, Catherine Klersy, Maria Luce Caputo, Marco Bergonti, Enos Bernasconi, Valeria Gaia, Christopher B Granger, Angelo Auricchio
BACKGROUND AND AIMS: Bloodstream infection (BSI) of any cause may lead to device infection in cardiac implantable electronic device (CIED) patients. Aiming for a better understanding of the diagnostic approach, treatment, and outcome, patients with an implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy and defibrillator (CRT-D) hospitalized with BSI were investigated. METHODS: This is a single-centre, retrospective, cohort analysis including consecutive ICD/CRT-D patients implanted between 2012 and 2021...
March 28, 2024: European Heart Journal
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JOURNAL ARTICLE
Joanna Popiolek-Kalisz, Tomasz Chrominski, Marcin Szczasny, Piotr Blaszczak
(1) Background: Nutritional status is a factor that impacts the patients' outcomes in various medical conditions including cardiovascular patients or surgical procedures. However, there is limited available information about its impact on the short-term outcomes of cardiac implantable electronic device (CIED) implantations. This study aimed to assess the relationship between nutritional status, complications, mortality risk, and length of stay at the hospital in patients undergoing CIED implantations. (2) Material and Methods: 588 patients who underwent CIED implantation in 2022 and 2023 were included in the retrospective analysis...
March 15, 2024: Nutrients
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JOURNAL ARTICLE
Jeremy S Treger, Ahmad B Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A Upadhyay
IMPORTANCE: Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy. OBJECTIVE: To develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate this criterion in an independent population. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study, the derivation cohort was from a single-center, prospective study of patients undergoing electrophysiological study from March 2016 through November 2019...
March 27, 2024: JAMA Cardiology
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JOURNAL ARTICLE
Neil D Wallace, Marliese Alexander, Jing Xie, David Ball, Fiona Hegi-Johnson, Nikki Plumridge, Shankar Siva, Mark Shaw, Susan Harden, Tom John, Ben Solomon, Ann Officer, Michael MacManus
INTRODUCTION: Smoking is a risk factor for the development of lung cancer and reduces life expectancy within the general population. Retrospective studies suggest that non-smokers have better outcomes after treatment for lung cancer. We used a prospective database to investigate relationships between pre-treatment smoking status and survival for a cohort of patients with stage III non-small-cell lung cancer (NSCLC) treated with curative-intent concurrent chemoradiotherapy (CRT). METHODS: All patients treated with CRT for stage III NSCLC at a major metropolitan cancer centre were prospectively registered to a database...
March 11, 2024: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
#17
JOURNAL ARTICLE
Miry Blich, Wisam Darawsha, Allon Eyal, Faheem Shehadeh, Monther Boulous, Lior Gepstein, Mahmoud Suleiman
BACKGROUND: Dilated cardiomyopathy (DCM) caused by Lamin A/C gene (LMNA) mutation is complicated with atrioventricular conduction disturbances, malignant ventricular arrhythmias and progressive severe heart failure. OBJECTIVE: We hypothesized that early cardiac resynchronization therapy (CRT) implantation in LMNA mutation carriers with an established indication for pacemaker or implantable cardioverter defibrillator (ICD), may preserve ejection fraction, and delay disease progression to end stage heart failure...
2024: American Journal of Cardiovascular Disease
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JOURNAL ARTICLE
D Sang, S M Fan, S Y Li, J T Zhang, H M Wang, X H Zhao, L J Zheng, P Liang, G B Xi, L M Zhao, Y R Zhang, P Yuan
Objective: To explore the efficacy and safety of Rivaroxaban in preventing catheter related thrombosis (CRT) in patients with breast cancer who are undergoing central venous catheter chemotherapy, and provide basis for making standardized prevention and treatment strategies. Methods: In this research, a prospective cohort study was adopted, and breast cancer patients who received central venous catheter chemotherapy in Sanhuan Cancer Hospital during September 2020 to March 2022 were selected as a treatment group to take the rivaroxaban anticoagulation therapy with 10 mg...
March 23, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
#19
JOURNAL ARTICLE
Alan J Bank, Christopher D Brown, Kevin V Burns, Katie M Johnson
BACKGROUND: Optimization of atrial-ventricular delay (AVD) during atrial sensing (SAVD) and pacing (PAVD) provides the most effective cardiac resynchronization therapy (CRT). We demonstrate a novel electrocardiographic methodology for quantifying electrical synchrony and optimizing SAVD/PAVD. METHODS: We studied 40 CRT patients with LV activation delay. Atrial-sensed to RV-sensed (As-RVs) and atrial-paced to RV-sensed (Ap-RVs) intervals were measured from intracardiac electrograms (IEGM)...
March 13, 2024: Pacing and Clinical Electrophysiology: PACE
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JOURNAL ARTICLE
Shu-Ai Luo, Yu-Ying Sun, Ya-Ting Zeng, Chun-Yu Huang
BACKGROUND: Endoscopic submucosal dissection (ESD) and surgical resection are the standard of care for cT1N0M0 esophageal cancer (EC), whereas definitive chemoradiotherapy (d-CRT) is a treatment option. Nevertheless, the comparative efficiency and safety of ESD, surgery and d-CRT for cT1N0M0 EC remain unclear. AIM: To compare the efficiency and safety of ESD, surgery and d-CRT for cT1N0M0 EC. METHODS: We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th, 2022...
February 16, 2024: World Journal of Gastrointestinal Endoscopy
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