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https://www.readbyqxmd.com/read/28431009/artefact-free-late-gadolinium-enhancement-imaging-in-patients-with-implanted-cardiac-devices-using-a-modified-broadband-sequence-current-strategies-and-results-from-a-real-world-patient-cohort
#1
Sebastian Hilbert, Alexander Weber, Kay Nehrke, Peter Börnert, Bernhard Schnackenburg, Sabrina Oebel, Ricardo Spampinato, Cathleen Rogge, Sergio Richter, Gerhard Hindricks, Ingo Paetsch, Cosima Jahnke
Aims: Cardiac magnetic resonance (CMR) imaging in patients with implanted cardiac devices is often limited by device-related imaging artefacts. Limitations can potentially be overcome by employing a broadband late gadolinium enhancement (LGE)-CMR imaging technique. The purpose of this study was to investigate the relationship between implanted cardiac devices and the optimal frequency offset on broadband LGE-CMR imaging to increase the artefact-free visibility of myocardial segments. Methods and results: A phantom study was performed to characterize magnetic field disturbances related to 15 different cardiac devices...
April 18, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28428489/superior-rhythm-discrimination-with-the-smartshock-technology-algorithm%C3%A3-results-of-the-implantable-defibrillator-with-enhanced-features-and-settings-for-reduction-of-inaccurate-detection-defense-trial
#2
Yasushi Oginosawa, Ritsuko Kohno, Toshihiro Honda, Kan Kikuchi, Masatsugu Nozoe, Takayuki Uchida, Hitoshi Minamiguchi, Koichiro Sonoda, Masahiro Ogawa, Takeshi Ideguchi, Yoshihisa Kizaki, Toshihiro Nakamura, Kageyuki Oba, Satoshi Higa, Keiki Yoshida, Soichi Tsunoda, Yoshihisa Fujino, Haruhiko Abe
BACKGROUND: Shocks delivered by implanted anti-tachyarrhythmia devices, even when appropriate, lower the quality of life and survival. The new SmartShock Technology(®)(SST) discrimination algorithm was developed to prevent the delivery of inappropriate shock. This prospective, multicenter, observational study compared the rate of inaccurate detection of ventricular tachyarrhythmia using the SST vs. a conventional discrimination algorithm.Methods and Results:Recipients of implantable cardioverter defibrillators (ICD) or cardiac resynchronization therapy defibrillators (CRT-D) equipped with the SST algorithm were enrolled and followed up every 6 months...
April 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28427417/novel-trigenic-cacna1c-des-mypn-mutations-in-a-family-of-hypertrophic-cardiomyopathy-with-early-repolarization-and-short-qt-syndrome
#3
Yanhong Chen, Hector Barajas-Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang, Dan Hu
BACKGROUND: Hypertrophic cardiomyopathy (HCM) patients with early repolarization (ER) pattern are at higher risk of ventricular arrhythmia, yet the genetic background of this situation has not been well investigated. Here we report novel trigenic mutations detected in a Chinese family of obstructive HCM with ER and short QT syndrome (SQTS). METHODS: Proband and family members underwent detailed medical assessments. DNAs were extracted from peripheral blood leukocytes for genetic screening with next generation method...
April 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28407139/economic-impact-of-remote-monitoring-after-implantable-defibrillators-implantation-in-heart-failure-patients-an-analysis-from-the-effect-study
#4
Alessandro Capucci, Antonio De Simone, Mario Luzi, Valeria Calvi, Giuseppe Stabile, Antonio D'Onofrio, Simone Maffei, Loira Leoni, Giovanni Morani, Raffaele Sangiuolo, Claudia Amellone, Catia Checchinato, Ernesto Ammendola, Gianfranco Buja
Aims: Heart failure (HF) patients with implantable cardioverter-defibrillators (ICD) require admissions for disease management and out-patient visits for disease management and assessment of device performance. These admissions place a significant burden on the National Health Service. Remote monitoring (RM) is an effective alternative to frequent hospital visits. The EFFECT study was a multicentre observational investigation aiming to evaluate the clinical effectiveness of RM compared with in-office visits standard management (SM)...
April 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28402713/optical-biometry-derived-axial-length-measurements-following-intravitreal-anti-vascular-endothelial-growth-factor-treatment-for-macular-edema
#5
George D Kymionis, Athanassios Giarmoukakis, Ioanna K Apostolidi, Styliani V Blazaki, Konstantinos I Tsoulnaras, Joanna Moschandrea, Sofia Panagopoulou, Miltiadis K Tsilimbaris
PURPOSE: To evaluate axial length (AL) alterations in patients with macular disease over the course of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment. METHODS: In this prospective, comparative study, 33 patients with macular edema underwent unilaterally intravitreal anti-VEGF therapy and were followed for two months; the contralateral eyes were considered as controls. Central retinal thickness (CRT) was measured with spectral-domain optical coherence tomography and AL with an IOL-Master optical biometer...
April 12, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28401860/lead-related-complications-in-quadripolar-versus-bipolar-left-ventricular-leads
#6
Shasank Rijal, Jonathan Wolfe, Rohit Rattan, Asad Durrani, Andrew D Althouse, Oscar C Marroquin, Sandeep Jain, Suresh Mulukutla, Samir Saba
BACKGROUND: Quadripolar left ventricular (LV) leads are capable of pacing from four different electrodes which allows for easier and more stable intra-operative lead positioning with optimal pacing parameters. We therefore investigated the rate of combined intra-operative and post-operative LV lead related events in quadripolar vs. bipolar LV lead cardiac resynchronization therapy (CRT) recipients in the real world setting. METHODS: We retrospectively collected data for N = 1441 patients at our institution implanted with quadripolar (n = 292) or bipolar (n = 1149) LV leads from 2012 to 2014 and followed them to the primary end-point of composite lead outcome defined as intra-operative lead implant failure or post-operative lead dislodgement or deactivations...
January 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28398490/the-prognostic-benefit-of-cardiac-resynchronization-therapy-is-greater-in-concordant-vs-discordant-left-bundle-branch-block-in-the-multicenter-automatic-defibrillator-implantation-trial-cardiac-resynchronization-therapy-madit-crt
#7
Luigi Padeletti, Alberto Aimo, Bella Vishenvsky, Arielle Schwartz, Scott McNitt, Paul J Wang, Arthur J Moss, Michele Emdin, Wojciech Zareba
Aims: Discordant and concordant left bundle branch block (dLBBB/cLBBB) are characterized by negative or positive T waves, respectively, in lateral leads. We assessed if the two morphologies are associated with different clinical status and prognosis in patients with heart failure (HF) and current indication to Cardiac Resynchronization Therapy (CRT)/CRT-Defibrillator (CRT-D). Methods and results: Baseline electrocardiograms of 1270 patients with LBBB in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy cohort were analysed to identify dLBBB and cLBBB...
April 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28394012/clinical-profile-and-management-of-outpatients-with-non-ischemic-and-non-hypertensive-systolic-heart-failure-analysis-of-the-polish-data-help-registry
#8
Justyna M Krzysztofik, Beata Kurian, Waldemar Banasiak, Ewa A Jankowska, Piotr Ponikowski
BACKGROUND: Although coronary artery disease and arterial hypertension are the most common etiologies underlying heart failure (HF), there are still many patients present with non-ischemic and non-hypertensive HF whose management remains very challenging. In this research study the clinical profile and applied treatment of patients with HF without coronary artery disease or hypertension versus patients with known etiology of HF (ischemic/hypertensive) were compared. METHODS: Clinical data about 5563 patients with stable systolic HF were obtained from prospective multicenter DATA-HELP registry performed between October and December 2009 in ambulatory clinics in Poland, in which 500 cardiologists and 290 GPs participated...
April 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28388657/clinical-decision-tool-for-crt-p-vs-crt-d-implantation-findings-from-prose-icd
#9
Victor Nauffal, Yiyi Zhang, Tanyanan Tanawuttiwat, Elena Blasco-Colmenares, John Rickard, Joseph E Marine, Barbara Butcher, Sanaz Norgard, Timm-Michael Dickfeld, Kenneth A Ellenbogen, Eliseo Guallar, Gordon F Tomaselli, Alan Cheng
BACKGROUND: Cardiac resynchronization therapy (CRT) devices reduce mortality through pacing-induced cardiac resynchronization and implantable cardioverter defibrillator (ICD) therapy for ventricular arrhythmias (VAs). Whether certain factors can predict if patients will benefit more from implantation of CRT pacemakers (CRT-P) or CRT defibrillators (CRT-D) remains unclear. METHODS AND RESULTS: We followed 305 primary prevention CRT-D recipients for the two primary outcomes of HF hospitalization and ICD therapy for VAs...
2017: PloS One
https://www.readbyqxmd.com/read/28387659/salivary-and-serum-hpv-antibody-levels-before-and-after-definitive-treatment-in-patients-with-oropharyngeal-squamous-cell-carcinoma
#10
Glenn J Hanna, Vishwajith Sridharan, Danielle N Margalit, Stephanie K La Follette, Nicole G Chau, Guilherme Rabinowits, Jochen H Lorch, Robert I Haddad, Roy B Tishler, Karen S Anderson, Jonathan D Schoenfeld
BACKGROUND: HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence. Laboratory assays that identify virally-mediated disease and predict HPV clearance in OPSCC may have important prognostic implications. OBJECTIVE: Here we investigated serum, salivary HPV16 early (E) antibodies before and after definitive chemoradiotherapy (CRT) in patients with locoregionally advanced OPSCC. METHODS: We prospectively measured salivary, serum samples at the beginning of and 6-7 weeks following the completion of CRT in 44 patients...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28383431/cardiac-electrophysiological-alterations-and-clinical-response-in-cardiac-resynchronization-therapy-with-a-defibrillator-treated-patients-affected-by-metabolic-syndrome
#11
Celestino Sardu, Matteo Santamaria, Stefania Funaro, Cosimo Sacra, Michelangela Barbieri, Pasquale Paolisso, Raffaele Marfella, Giuseppe Paolisso, Maria Rosaria Rizzo
Metabolic syndrome (MS) is a multifactorial disease that can affect clinical outcomes in patients treated by Cardiac Resynchronization Therapy with a defibrillator (CRT-d).Ninety-one patients received a CRT-d. According to clinical diagnosis, the study population was divided into 46 MS (cases) versus 45 no MS (controls) patients. These patients were followed by clinical, instrumental assessment, and device telemetric interrogations at follow-up. The design of the study was to evaluate the functionality of the CRT-d leads, the arrhythmic events, the CRT-d response, and the clinical outcomes at follow-up...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28376080/long-term-results-and-recurrence-patterns-from-scalop-a-phase-ii-randomised-trial-of-gemcitabine-or-capecitabine-based-chemoradiation-for-locally-advanced-pancreatic-cancer
#12
C N Hurt, S Falk, T Crosby, A McDonald, R Ray, G Joseph, J Staffurth, R A Abrams, G Griffiths, T Maughan, S Mukherjee
BACKGROUND: SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS: Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m(-2) days 1, 8, 15; CAP 830 mg m(-2) days 1-21 q28 days) patients with stable/responding disease, tumour ⩽6 cm, and WHO Performance Status 0-1 were randomised to receive one cycle GEMCAP followed by CAP (830 mg m(-2) b...
April 4, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28359512/should-nonischemic-crt-candidates-receive-crt-p-or-crt-d
#13
EDITORIAL
Wayne C Levy
No abstract text is available yet for this article.
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28357632/radiotherapy-for-adrenal-gland-metastases-from-hepatocellular-carcinoma
#14
B-Y Yuan, Y Hu, L Zhang, Y-H Chen, Y-Y Dong, Z-C Zeng
BACKGROUND: Several studies have found benefits of radiotherapy for adrenal metastasis from hepatocellular carcinoma (HCC). However, the efficacy, safety and outcome issues have not yet been fully addressed. Therefore, we performed this study to further elucidate the feasibility and outcome of radiotherapy in treating adrenal metastasis from HCC. METHODS: We retrospectively analyzed 81 patients with adrenal metastasis from HCC between 2001 and 2015. Eighteen patients received helical tomotherapy and 63 patients received conventional radiotherapy, including two-dimensional (2-D) or three-dimensional conformal radiotherapy (3-D CRT)...
March 29, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28341965/reliability-of-a-laryngo-pharyngeal-esthesiometer-and-a-method-for-measuring-laryngo-pharyngeal-mechano-sensitivity-in-a-prospectively-recruited-cohort-of-patients
#15
Luis F Giraldo-Cadavid, Javier Burguete, Felipe Rueda, Ana M Galvis, Natalia Castaneda, Luis M Agudelo-Otalora, William D Moscoso, Nelson Paez, Secundino Fernandez
There are not reliable methods for measuring laryngo-pharyngeal mechano-sensitivity (LPMS). We aimed to determine the reliability of a new method for measuring LPMS using a new laryngo-pharyngeal esthesiometer (LPEER) in a prospective cohort of dysphagic stroke and non-dysphagic patients. The patients underwent clinical and endoscopic evaluations of swallowing (FESSST). The LPMS assessments consisted of measurements by an expert and a novel rater of the laryngeal-adductor reflex threshold (LART), cough reflex threshold (CRT) and gag reflex threshold (GRT) using the LPEER...
March 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28339659/the-use-of-guideline-recommended-beta-blocker-therapy-in-primary-prevention-implantable-cardioverter-defibrillator-patients-insight-from-danish-nationwide-registers
#16
Anne-Christine Ruwald, Gunnar Hilmar Gislason, Michael Vinther, Jens Brock Johansen, Jens Cosedis Nielsen, Helen Høgh Petersen, Christian Torp-Pedersen, Sam Riahi, Christian Jøns
Aims: We aimed to examine the use of guideline recommended beta-blocker therapy prior to and after primary prevention implantable cardioverter defibrillator (ICD) implantation in a 'real-life' setting. Methods and results: From the Danish Pacemaker and ICD Registry we identified all 1st-time primary prevention ICD and cardiac resynchronization therapy defibrillator (CRT-D) implantations in Denmark from 2007-12 (n = 2935). Use of beta-blocker, type and dose was acquired through the Danish Prescription Registry...
February 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28329322/utilization-and-in-hospital-complications-of-cardiac-resynchronization-therapy-trends-in-the-united-states-from-2003-to-2013
#17
Seyed Mohammadreza Hosseini, Kasra Moazzami, Guy Rozen, Jeena Vaid, Ahmed Saleh, E Kevin Heist, Mark Vangel, Jeremy N Ruskin
Aims: Cardiac resynchronization therapy (CRT) device implantation has been shown to reduce morbidity and mortality in selected patients with heart failure. We sought to investigate the utilization and in-hospital complications of cardiac resynchronization therapy defibrillator (CRT-D) and pacemaker (CRT-P) implantations in the United States from 2003 to 2013. Methods and results: Patients receiving CRT-D or CRT-P were identified in the National Inpatient Sample database (NIS), using the International Classification of Diseases-Ninth Revision-Clinical Modification procedure codes...
March 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28329280/implantable-cardioverter-defibrillators-for-primary-prevention-of-death-in-left-ventricular-dysfunction-with-and-without-ischaemic-heart-disease-a-meta-analysis-of-8567-patients-in-the-11-trials
#18
Matthew J Shun-Shin, Sean L Zheng, Graham D Cole, James P Howard, Zachary I Whinnett, Darrel P Francis
Aims: Primary prevention implantable cardioverter defibrillators (ICDs) are established therapy for reducing mortality in patients with left ventricular systolic dysfunction and ischaemic heart disease (IHD). However, their efficacy in patients without IHD has been controversial. We undertook a meta-analysis of the totality of the evidence. Methods and results: We systematically identified all RCTs comparing ICD vs. no ICD in primary prevention. Eligible RCTs were those that recruited patients with left ventricular dysfunction, reported all-cause mortality, and presented their results stratified by the presence of IHD (or recruited only those with or without)...
February 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28297459/on-the-use-of-a-convolution-superposition-algorithm-for-plan-checking-in-lung-stereotactic-body-radiation-therapy
#19
Nicholas Hardcastle, Bradley M Oborn, Annette Haworth
Stereotactic body radiation therapy (SBRT) aims to deliver a highly conformal ablative dose to a small target. Dosimetric verification of SBRT for lung tumors presents a challenge due to heterogeneities, moving targets, and small fields. Recent software (M3D) designed for dosimetric verification of lung SBRT treatment plans using an advanced convolution-superposition algorithm was evaluated. Ten lung SBRT patients covering a range of tumor volumes were selected. 3D CRT plans were created using the XiO treatment planning system (TPS) with the superposition algorithm...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294364/predictors-and-long-term-outcome-of-super-responders-to-cardiac-resynchronization-therapy
#20
Abdul Ghani, Peter Paul H M Delnoy, Ahmet Adiyaman, Jan Paul Ottervanger, Anand R Ramdat Misier, Jaap Jan J Smit, Arif Elvan
BACKGROUND: The level of improvement in left ventricular ejection fraction (LVEF) in super-responders to cardiac resynchronization therapy (CRT) is exceptional. However, the long-term prognosis remains unknown in a large population. HYPOTHESIS: Whether super-responders haven good long-term outcomes. METHODS: We registered 347 patients with primary CRT-D indication. Super-response was defined by LVEF >50% at follow-up echocardiogram. Best-subset regression analysis identified predictors of super-response...
March 14, 2017: Clinical Cardiology
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