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https://www.readbyqxmd.com/read/28721837/effects-of-progressive-resistance-training-combined-with-a-protein-enriched-lean-red-meat-diet-on-health-related-quality-of-life-in-elderly-women-secondary-analysis-of-a-4-month-cluster-randomised-controlled-trial
#1
Susan J Torres, Sian Robinson, Liliana Orellana, Stella L O'Connell, Carley A Grimes, Niamh L Mundell, David W Dunstan, Caryl A Nowson, Robin M Daly
Resistance training (RT) and increased dietary protein are recommended to attenuate age-related muscle loss in the elderly. This study examined the effect of a lean red meat protein-enriched diet combined with progressive resistance training (RT+Meat) on health-related quality of life (HR-QoL) in elderly women. In this 4-month cluster randomised controlled trial, 100 women aged 60-90 years (mean 73 years) from self-care retirement villages participated in RT twice a week and were allocated either 160 g/d (cooked) lean red meat consumed across 2 meals/d, 6 d/week or ≥1 serving/d (25-30 g) carbohydrates (control group, CRT)...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28716973/incremental-benefit-of-cardiac-resynchronisation-therapy-with-versus-without-a-defibrillator
#2
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Dieter Nuyens, Hugo Van Herendael, Maximo Rivero-Ayerza, Wilson H Tang, Wilfried Mullens
OBJECTIVE: To determine the incremental value of implantable cardioverter defibrillators (ICD) in contemporary optimally treated patients with heart failure (HF) undergoing cardiac resynchronisation therapy (CRT). METHODS: Consecutive patients with HF undergoing CRT-pacemaker (CRT-P) or CRT-defibrillator (CRT-D) implantation in a single tertiary care centre between October 2008 and August 2015 were retrospectively evaluated. For patients with a primary prevention indication of the CRT-D, no benefit of the ICD was defined as absence of appropriate therapy (device analysis) or lethal ventricular tachyarrhythmias (mode of death analysis) during follow-up...
July 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28712692/volumetric-parameters-of-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-can-predict-histopathologic-treatment-response-after-neoadjuvant-chemoradiotherapy-in-pancreatic-adenocarcinoma
#3
Makoto Sakane, Mitsuaki Tatsumi, Masatoshi Hori, Hiromitsu Onishi, Takahiro Tsuboyama, Atsushi Nakamoto, Takashi Ota, Hidetoshi Eguchi, Kenichi Wakasa, Jun Hatazawa, Noriyuki Tomiyama
PURPOSE: The purpose of this study was to investigate the clinical potential of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography (FDG PET/CT) to evaluate histopathologic effects of preoperative chemoradiotherapy (CRT) in pancreatic adenocarcinoma, with particular focus on volumetric PET/CT parameters. MATERIAL AND METHODS: This study included 25 patients with pancreatic adenocarcinoma who underwent radical surgery after gemcitabine- and S-1-based preoperative-CRT...
June 23, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28708197/risk-stratification-personalised-model-for-prediction-of-life-threatening-ventricular-tachyarrhythmias-in-patients-with-chronic-heart-failure
#4
Alexander Vladimirovich Frolov, Tatjana Gennadjevna Vaikhanskaya, Olga Petrovna Melnikova, Anatoly Pavlovich Vorobiev, Ludmila Michajlovna Guel
BACKGROUND: The development of prognostic factors of life-threatening ventricular tachyarrhythmias (VTA) and sudden cardiac death (SCD) continues to maintain its priority and relevance in cardiology. The development of a method of personalised prognosis based on multifactorial analysis of the risk factors associated with life-threatening heart rhythm disturbances is considered a key research and clinical task. AIM: To design a prognostic and mathematical model to define personalised risk for life-threatening VTA in patients with chronic heart failure (CHF)...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28688704/long-term-survival-of-patients-with-left-bundle-branch-block-who-are-hypo-responders-to-cardiac-resynchronization-therapy
#5
Himabindu Vidula, Valentina Kutyifa, Scott McNitt, Ilan Goldenberg, Scott D Solomon, Arthur J Moss, Wojciech Zareba
Guidelines support cardiac resynchronization therapy with a defibrillator (CRT-D) in mild heart failure (HF) patients with left bundle branch block (LBBB). However, not all patients demonstrate echocardiographic or clinical response to CRT-D. We aimed to evaluate the long-term outcomes of echocardiographic hypo-responders and clinical hypo-responders to CRT-D with LBBB in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy. Five-hundred thirty-four patients with LBBB in the CRT-D arm were followed for 5...
June 13, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28679168/risk-stratification-of-cardiovascular-and-heart-failure-hospitalizations-using-integrated-device-diagnostics-in-patients-with-a-cardiac-resynchronization-therapy-defibrillator
#6
Haran Burri, Antoine da Costa, Aurelio Quesada, Renato Pietro Ricci, Stefano Favale, Nicolas Clementy, Gabriele Boscolo, Federico Segura Villalobos, Lorenza Mangoni di S Stefano, Vinod Sharma, Giuseppe Boriani
Aims: Cardiac resynchronization therapy defibrillators (CRT-D) are able to monitor various parameters that may be combined by an automatic algorithm to provide a heart failure risk status (HFRS). We sought to validate the HFRS for stratifying patient risk, evaluate its association with heart failure (HF) symptoms, and investigate its utility for triage of automatic alerts. Methods and results: Data from 722 patients included in the MORE-CARE trial were analysed in a post hoc analysis...
June 30, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28666907/clinical-outcomes-of-helical-conformal-versus-nonconformal-palliative-radiation-therapy-for-axial-skeletal-metastases
#7
Kara D Romano, Daniel M Trifiletti, Kristine Bauer-Nilsen, Nolan A Wages, William T Watkins, Paul W Read, Timothy N Showalter
PURPOSE: Palliative radiation therapy (RT) for bone metastases has traditionally been delivered with conventional, nonconformal RT (NCRT). Conformal RT (CRT) is potentially more complex and expensive than NCRT, but may reduce normal tissue dose and subsequently toxicity. In this retrospective analysis, we compared CRT with NCRT to investigate the association between conformality and toxicity. METHODS AND MATERIALS: A retrospective analysis of patients receiving palliative RT for axial skeletal bone metastases from 2012 to 2014 was conducted...
April 9, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28666319/cause-of-death-analysis-in-patients-with-cardiac-resynchronization-therapy-with-or-without-a-defibrillator-a-systematic-review-and-proportional-meta-analysis
#8
Sérgio Barra, Rui Providência, Rudolf Duehmke, Serge Boveda, David Begley, Andrew Grace, Kumar Narayanan, Anthony Tang, Eloi Marijon, Sharad Agarwal
Aims: The additional benefit of a defibrillator in cardiac resynchronization therapy (CRT) patients is a matter of debate. Cause-of-death analysis in a CRT population has been recently proposed as a useful approach to gain insight into this problem. We performed a systematic review and meta-analysis looking at cause of death in studies involving CRT subjects with (CRT-D) or without (CRT-P) a defibrillator. Methods and results: Literature search performed from inception to 31 March 2016 for relevant studies...
June 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28662682/pooled-dna-sequencing-identifies-genomic-regions-of-selection-in-nigerian-isolates-of-plasmodium-falciparum
#9
Kolapo M Oyebola, Emmanuel T Idowu, Yetunde A Olukosi, Taiwo S Awolola, Alfred Amambua-Ngwa
BACKGROUND: The burden of falciparum malaria is especially high in sub-Saharan Africa. Differences in pressure from host immunity and antimalarial drugs lead to adaptive changes responsible for high level of genetic variations within and between the parasite populations. Population-specific genetic studies to survey for genes under positive or balancing selection resulting from drug pressure or host immunity will allow for refinement of interventions. METHODS: We performed a pooled sequencing (pool-seq) of the genomes of 100 Plasmodium falciparum isolates from Nigeria...
June 29, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28653315/effectiveness-of-medtronic-carelink-express-system-in-identifying-patients-with-high-energy-electrotherapy-devices-requiring-clinically-significant-intervention
#10
Marcin Grabowski, Sabina Sadecka, Andrzej Cacko, Marcin Michalak, Leszek Blicharz, Paweł Balsam, Grzegorz Opolski
BACKGROUND: The number of patients with implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy and defibrillator (CRT-D) is growing. This results in high workloads for centers performing standard controls (SC) of these systems. Medtronic CareLink Express (MCLE) is a solution enabling remote controls (RC) of implantable devices. In cases of detecting arrhythmias or device malfunctioning, it automatically generates alarms transmitted to the controlling physician...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28653309/refined-heart-failure-detection-algorithm-for-improved-clinical-reliability-of-optivol-alerts-in-crt-d-recipients
#11
Mate Vamos, Noemi Nyolczas, Zsolt Bari, Peter Bogyi, Balazs Muk, Barna Szabo, Bettina Ancsin, Robert G Kiss, Gabor Z Duray
BACKGROUND: The reliability of intrathoracic impedance monitoring for prediction of heart failure (HF) by implantable cardiac devices is controversial. Despite using additional device-based parameters described in the PARTNERS HF study, such as new onset of arrhythmias, abnormal autonomics, low biventricular pacing rate or patient activity level, the predictive power of device diagnostic algorithm is still in doubt. The objective of this study was to compare the device diagnostic algorithm described in the PARTNERS HF study to a newly developed algorithm applying refined diagnostic criteria...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28648948/randomized-phase-ii-study-comparing-prophylactic-cranial-irradiation-alone-to-prophylactic-cranial-irradiation-and-consolidative-extra-cranial-irradiation-for-extensive-disease-small-cell-lung-cancer-ed-sclc-nrg-oncology-rtog-0937
#12
Elizabeth M Gore, Chen Hu, Alexander Y Sun, Daniel F Grimm, Suresh S Ramalingam, Neal E Dunlap, Kristin A Higgins, Maria Werner-Wasik, Aaron M Allen, Puneeth Iyengar, Gregory M M Videtic, Russell K Hales, Ronald C McGarry, James J Urbanic, Anthony T Pu, Candice A Johnstone, Volker W Stieber, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: RTOG-0937 is a randomized phase-II trial evaluating 1-year OS with PCI or PCI plus consolidative radiation therapy (cRT) to intra-thoracic disease and extracranial metastases for ED-SCLC. METHODS: Patients with 1-4 extracranial metastases were eligible after CR or PR to chemotherapy. Randomization was to PCI or PCI+cRT to the thorax and metastases. Original stratification included PR vs CR after chemotherapy and 1 vs 2-4 metastases; age < 65 vs > 65 was added after an observed imbalance...
June 22, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28629896/randomized-phase-ii-study-of-preoperative-chemoradiotherapy-panitumumab-followed-by-consolidation-chemotherapy-in-potentially-operable-locally-advanced-stage-iiia-n2-non-small-cell-lung-cancer-nrg-oncology-rtog-0839
#13
Martin J Edelman, Chen Hu, Quynh-Thu Le, Jessica S Donington, Warren D D'Souza, Adam P Dicker, Billy W Loo, Elizabeth M Gore, Gregory M M Videtic, Nathaniel R Evans, Joseph W Leach, Maximilian Diehn, Steven J Feigenberg, Yuhchyau Chen, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: Multimodality therapy has curative potential in locally advanced non-small cell lung cancer (LASCLC). Mediastinal nodal sterilization (MNS) after induction chemoradiotherapy (CRT) can serve as an intermediate marker for efficacy. NRG Oncology RTOG 0229 demonstrated the feasibility and efficacy of combining full dose radiation (61.2Gy) with chemotherapy followed by resection and chemotherapy. Based upon that experience and evidence that epidermal growth factor receptor (EGFR) antibodies are radiosensitizing, we explored adding panitumumab to CRT followed by resection and consolidation chemotherapy in LANSCLC with a primary endpoint of MNS...
June 16, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28626201/survival-and-heart-failure-hospitalization-in-patients-with-cardiac-resynchronization-therapy-with-or-without-a-defibrillator-for-primary-prevention-in-japan%C3%A3-analysis-of-the-japan-cardiac-device-treatment-registry-database
#14
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
BACKGROUND: Randomized control trials comparing the effectiveness of cardiac resynchronization therapy devices, with (CRT-D) or without (CRT-P) a defibrillator, are scarce in heart failure patients with no prior sustained ventricular tachyarrhythmias.Methods and Results:The Japan Cardiac Device Treatment Registry (JCDTR) has data for 2714 CRT-D and 555 CRT-P recipients for primary prevention with an implantation date between January 2011 and August 2015. Of these patients, follow-up data were available for 717...
June 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28625381/utilization-of-cardiac-resynchronization-therapy-in-eligible-patients-hospitalized-for-heart-failure-and-its-association-with-patient-outcomes
#15
Tiffany C Randolph, Anne S Hellkamp, Emily P Zeitler, Gregg C Fonarow, Adrian F Hernandez, Kevin L Thomas, Eric D Peterson, Clyde W Yancy, Sana M Al-Khatib
OBJECTIVES: We examined trends in CRT utilization overall and by sex and race and to assess whether CRT use is associated with a reduction in HF hospitalization and mortality. BACKGROUND: It is unknown whether underutilization and race/sex-based differences in cardiac resynchronization therapy (CRT) use have persisted. The association between CRT and heart failure (HF) hospitalization and mortality in real-world practice remains unclear. METHODS: We linked 72,008 HF patients from 388 hospitals participating in Get With The Guidelines HF eligible for CRT with Centers for Medicare & Medicaid Services data to assess CRT utilization trends, HF hospitalization rates, and all-cause mortality...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28624026/the-prediction-of-the-treatment-response-of-cervical-nodes-using-intravoxel-incoherent-motion-diffusion-weighted-imaging
#16
Simona Marzi, Francesca Piludu, Giuseppe Sanguineti, Laura Marucci, Alessia Farneti, Irene Terrenato, Raul Pellini, Maria Benevolo, Renato Covello, Antonello Vidiri
PURPOSE: To investigate the predictive role of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) parameters on cervical nodal response to chemo-radiotherapy (CRT) of head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Patients with pathologically confirmed HNSCC were included in the present prospective study, having at least one positive cervical lymph node (LN). They received concomitant CRT and underwent three serial IVIM-DWI investigations: before, at mid-treatment and after treatment completion...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28621318/natural-killer-like-signature-observed-post-therapy-in-locally-advanced-rectal-cancer-is-a-determinant-of-pathological-response-and-improved-survival
#17
Matthew Alderdice, Philip D Dunne, Aidan J Cole, Paul G O'Reilly, Darragh G McArt, Vicky Bingham, Marc-Aurel Fuchs, Stephen McQuaid, Maurice B Loughrey, Graeme I Murray, Leslie M Samuel, Mark Lawler, Richard H Wilson, Manuel Salto-Tellez, Vicky M Coyle
Around 12-15% of patients with locally advanced rectal cancer undergo a pathologically complete response (tumor regression grade 4) to long-course preoperative chemoradiotherapy; the remainder exhibit a spectrum of tumor regression (tumor regression grade 1-3). Understanding therapy-related transcriptional alterations may enable better prediction of response as measured by progression-free and overall survival, in addition to aiding the development of improved strategies based on the underlying biology of the disease...
June 16, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28615060/outcome-of-proximal-esophageal-cancer-after-definitive-combined-chemo-radiation-a-swiss-multicenter-retrospective-study
#18
Evelyn Herrmann, Nando Mertineit, Berardino De Bari, Laura Hoeng, Francesca Caparotti, Dominic Leiser, Raphael Jumeau, Nikola Cihoric, Alexandra D Jensen, Daniel M Aebersold, Mahmut Ozsahin
OBJECTIVE: To report oncological outcomes and toxicity rates, of definitive platin-based chemoradiadiationtherapy (CRT) in the management of proximal esophageal cancer. METHODS: We retrospectively reviewed the medical records of patients with cT1-4 cN0-3 cM0 cervical esophageal cancer (CEC) (defined as tumors located below the inferior border of the cricoid cartilage, down to 22 cm from the incisors) treated between 2004 and 2013 with platin-based definitive CRT in four Swiss institutions...
June 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28600804/noninvasive-pulmonary-transit-time-a-new-parameter-for-general-cardiac-performance
#19
Anouk G W de Lepper, Ingeborg H F Herold, Salvatore Saporito, R Arthur Bouwman, Massimo Mischi, Hendrikus H M Korsten, Koen D Reesink, Patrick Houthuizen
INTRODUCTION: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT). METHODS: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)≤35% and QRS≥120 ms...
June 9, 2017: Echocardiography
https://www.readbyqxmd.com/read/28599667/multipolar-pacing-by-cardiac-resynchronization-therapy-with-a-defibrillators-treatment-in-type-2-diabetes-mellitus-failing-heart-patients-impact-on-responders-rate-and-clinical-outcomes
#20
Celestino Sardu, Michelangela Barbieri, Matteo Santamaria, Valerio Giordano, Cosimo Sacra, Pasquale Paolisso, Alessandro Spirito, Raffaele Marfella, Giuseppe Paolisso, Maria Rosaria Rizzo
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a multi factorial disease, affecting clinical outcomes in failing heart patients treated by cardiac resynchronization therapy with a defibrillator (CRT-d). METHODS: One hundred and ninety-five T2DM patients received a CRT-d treatment. Randomly the study population received a CRT-d via multipolar left ventricle (LV) lead pacing (n 99, multipolar group), vs a CRT-d via bipolar LV pacing (n 96, bipolar group). These patients were followed by clinical, and instrumental assessment, and telemetric device control at follow up...
June 9, 2017: Cardiovascular Diabetology
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