Beining Li, Peng Hu, Kang Liu, Wenchao Xu, Jiaxin Wang, Qinyu Li, Bingliang Chen, Yuxuan Deng, Chenglin Han, Taotao Sun, Xinqi Liu, Mingchao Li, Tao Wang, Jihong Liu, Huang Lin, Ke Rao
BACKGROUND: Diabetes mellitus-induced erectile dysfunction (DMED) has become a common disease in adult men that can seriously reduce the quality of life of patients, and new therapies are urgently needed. miRNA-100 has many targets and can induce autophagy and reduce fibrosis by inhibiting the mTOR pathway and the TGF-β pathway. However, no research has been conducted with miR-100 in the field of DMED, and the specific mechanism of action is still unclear. OBJECTIVES: To ascertain the effects of miR-100 on corpus cavernosum tissue of DMED rats and vascular endothelial cells in a high glucose environment and to elucidate the relevant mechanisms in autophagy, fibrosis and inflammation to find a new approach for the DMED therapy...
January 16, 2024: Andrology