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https://www.readbyqxmd.com/read/29154455/translational-evidence-of-prothrombotic-and-inflammatory-endothelial-damage-in-cushing-syndrome-after-remission
#1
Gloria Aranda, Rebeca Fernandez-Ruiz, Marta Palomo, Mónica Romo, Mireia Mora, Irene Halperin, Gregori Casals, Joaquim Enseñat, Oscar Vidal, Maribel Diaz-Ricart, Felicia A Hanzu
OBJECTIVE: Sustained evidence from observational studies indicates that after remission of Cushing Syndrome (CS) a cardiovascular risk phenotype persists. Here we performed a translational study in active CS and CS in remission to evaluate the subclinical cardiometabolic burden and to explore the direct proinflammatory and prothrombotic potential of their sera on the endothelium in an in vitro translational atherothrombotic cell model. PATIENTS: Cross-sectional study...
November 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29153673/pregnancy-complications-and-later-vascular-ultrasound-measures-a-cohort-study
#2
Emily W Harville, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Olli T Raitakari
OBJECTIVES: Pregnancy complications predict or even predispose to later cardiovascular disease in the mother. We examined whether pregnancy complications are associated with post-pregnancy measures of endothelial dysfunction and arterial stiffness. STUDY DESIGN: Prospective cohort; Data for 847 women female participants in the Cardiovascular Risk in Young Finns study were linked with the national birth registry. Preterm birth (<37weeks), low birthweight (<2500g), small-for-gestational-age (weight <10th percentile for gestational age), and hypertensive disorders of pregnancy were examined as predictors of later vascular measures...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29151484/oral-administration-of-glucosamine-improves-vascular-endothelial-function-by-modulating-intracellular-redox-state
#3
Atsushi Katoh, Hisashi Kai, Haruhito Harada, Hiroshi Niiyama, Hisao Ikeda
Glucosamine, used to treat osteoarthritis, has been shown to have anti-inflammatory and anti-atherosclerotic effects in experimental studies. A recent cohort study has demonstrated that the use of glucosamine was significantly associated with decreased total mortality. Vascular endothelial function is a potent surrogate marker of atherosclerosis and cardiovascular mortality where oxidative stress could participate. Therefore, we investigated whether glucosamine improves vascular endothelial function and intracellular redox state...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29142493/cervical-arterial-fibromuscular-dysplasia-in-a-biethnic-population-a-retrospective-study-in-the-u-s-mexican-border
#4
Ihtesham A Qureshi, Gustavo J Rodriguez, Tatiana Chacon-Quesada, Gavito-Higuera Jose, Salvador Cruz-Flores, Alberto Maud
Background  There have been studies trying to characterize Fibromuscular Dysplasia (FMD); however, most of them are based in mainly non-Hispanic sample. The objective of this study is to better understand the epidemiology and clinical characteristics of craniocervical FMD in the Hispanic population. Methods  We retrospectively reviewed the cerebral angiograms performed in our center in a period of 3.5 years under any indication looking for angiographic patterns of FMD. Exclusion criteria consisted of cases in which the first angiogram was done when the patients were younger than 18 years...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29142122/adaptive-immune-responses-following-senecavirus-a-infection-in-pigs
#5
Mayara F Maggioli, Steve Lawson, Marcelo de Lima, Lok R Joshi, Tatiane C Faccin, Fernando V Bauermann, Diego G Diel
Senecavirus A (SVA), an emerging picornavirus of swine, causes vesicular disease (VD) that is clinically indistinguishable from foot-and-mouth disease (FMD) in pigs. Many aspects of SVA interactions with the host and the host immune responses to infection, however, remain unknown. In the present study, humoral and cellular immune responses to SVA were evaluated following infection in pigs. We show that SVA infection elicited an early and robust neutralizing antibody (NA) response, which coincided with and was strongly correlated with VP2- and VP3-specific IgM responses...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29139092/effects-of-allopurinol-on-endothelial-function-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#6
REVIEW
Arrigo F G Cicero, Matteo Pirro, Gerald F Watts, Dimitri P Mikhailidis, Maciej Banach, Amirhossein Sahebkar
INTRODUCTION: Uric acid (UA), the final product of purine catabolism, may be associated with an increased risk of cardiovascular disease. AIM: The aim of this meta-analysis of randomized placebo-controlled trials was to evaluate whether lowering serum UA (SUA) levels with allopurinol is associated with improved flow-mediated dilation (FMD), a validated marker of early vascular damage. METHODS: A literature search was carried out from inception until 20 June 2017...
November 14, 2017: Drugs
https://www.readbyqxmd.com/read/29132034/impact-of-flow-mediated-dilatation-and-coronary-calcification-in-providing-complementary-information-on-the-severity-of-coronary-artery-disease
#7
Kentaro Arakawa, Mutsuki Ohno, Mutsuo Horii, Tomoaki Ishigami, Kazuo Kimura, Kouichi Tamura
BACKGROUND AND AIMS: Endothelial dysfunction and coronary artery calcification (CAC) may represent two distinct and separate processes in the development of coronary atherosclerosis. However, the interaction between these factors in determining the development of coronary artery disease (CAD) is uncertain. METHODS: Brachial artery flow-mediated dilatation (FMD) was measured by high-resolution ultrasound before coronary angiography, in 156 patients undergoing coronary CT angiography on suspicion of CAD (M/F 100/56, age 67 ± 11yrs)...
November 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29131837/evidence-for-congruent-impairment-in-micro-and-macrovascular-function-in-type-1-diabetes
#8
Concetta Irace, Valentina Messiniti, Bruno Tassone, Claudio Cortese, Eugene J Barrett, Agostino Gnasso
Diabetes affects large and small vessels through mechanisms only partially known. In the present study, we evaluated the function of capillaries and large arteries in subjects with type 1 diabetes mellitus (T1DM) to study the effect of chronic hyperglycemia in the absence of other cardiovascular risk factors. Twenty-five subjects with T1DM and 12 healthy age-matched controls were enrolled. Nine patients had mild or moderate retinopathy. Contrast enhanced ultrasound was used to measure perfusion of the deep forearm flexor muscle of the non-dominant arm at rest (baseline) and after an ischemic stimulus (reactive hyperemia)...
2017: PloS One
https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#9
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
November 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29124905/rapid-and-simple-detection-of-foot-and-mouth-disease-virus-evaluation-of-a-cartridge-based-molecular-detection-system-for-use-in-basic-laboratories
#10
K V Goller, V Dill, M Madi, P Martin, Y Van der Stede, V Vandenberge, B Haas, S Van Borm, F Koenen, C J Kasanga, N Ndusilo, M Beer, L Liu, V Mioulet, B Armson, D P King, V L Fowler
Highly contagious transboundary animal diseases such as foot-and-mouth disease (FMD) are major threats to the productivity of farm animals. To limit the impact of outbreaks and to take efficient steps towards a timely control and eradication of the disease, rapid and reliable diagnostic systems are of utmost importance. Confirmatory diagnostic assays are typically performed by experienced operators in specialized laboratories, and access to this capability is often limited in the developing countries with the highest disease burden...
November 9, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29120385/hospital-audit-as-a-useful-tool-in-the-process-of-introducing-falsified-medicines-directive-fmd-into-hospital-pharmacy-settings-a-pilot-study
#11
Urszula Religioni, Damian Swieczkowski, Anna Gawrońska, Anna Kowalczuk, Mariola Drozd, Mikołaj Zerhau, Dariusz Smoliński, Stanisław Radomiński, Natalia Cwalina, David Brindley, Miłosz J Jaguszewski, Piotr Merks
BACKGROUND: Recently, the European Union has introduced the Falsified Medicines Directive (FMD). Additionally, in early 2016, a Delegated Act (DA) related to the FMD was published. The main objective of this study was to evaluate the usefulness of external audits in the context of implementing new regulations provided by the FMD in the secondary care environment. METHODS: The external, in-person workflow audits were performed by an authentication company in three Polish hospital pharmacies...
November 9, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29117072/workplace-strategies-to-prevent-sitting-induced-endothelial-dysfunction
#12
Nicholas T Kruse, William E Hughes, Roberto M Benzo, Lucas J Carr, Darren P Casey
Prolonged sitting induces endothelial dysfunction in healthy young adults which has been demonstrated to be offset by intermittent fidgeting and standing. No information exists on the impact of sitting and endothelial dysfunction in sedentary middle-aged adults, and whether common workplace counter-interventions (i.e. desk-standing/desk-pedaling) mitigate sitting-induced endothelial dysfunction. PURPOSE: The objective of this study was to examine whether breaking up prolonged sitting with intermittent standing or under-desk pedaling prevents sitting-induced popliteal artery endothelial dysfunction in middle-aged sedentary, overweight/obese office workers...
November 7, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29108665/evaluation-of-a-polyvalent-foot-and-mouth-disease-virus-vaccine-containing-a-saudi-95-against-field-challenge-on-large-scale-dairy-farms-in-saudi-arabia-with-the-emerging-a-asia-g-vii-viral-lineage
#13
Nicholas A Lyons, Anna B Ludi, Ginette Wilsden, Pip Hamblin, Ibrahim Ahmed Qasim, Simon Gubbins, Donald P King
In 2015, foot-and-mouth disease (FMD) viruses of the A/ASIA/G-VII lineage emerged from the Indian sub-continent to cause outbreaks in the Middle and Near East. A factor which has been proposed to have contributed to the rapid spread of this lineage is the poor in vitro vaccine-match of field isolates to vaccine strains that are commonly used in the region. This study used data from outbreaks on four large-scale dairy farms using routine vaccination in Saudi Arabia, to evaluate the impact of vaccination and learn how to manage outbreaks more effectively in this setting...
November 3, 2017: Vaccine
https://www.readbyqxmd.com/read/29103677/enhanced-protection-against-fmdv-in-cattle-after-prime-boost-vaccination-based-on-mucosal-and-inactivated-fmd-vaccine
#14
Manar E Khalifa, Ayman H El-Deeb, Sayed M Zeidan, Hussein A Hussein, Hany I Abu-El-Naga
Improved immunization and control strategies and platforms are greatly needed for foot and mouth disease virus (FMDV) and mucosal vaccines propose an effective strategy for the control FMDV by blocking viral entry. In this study, several immunization strategies, using two FMDV vaccine formulations, including Montanide ISA 206 oil-based FMD inactivated vaccine and Montanide IMS 1313 VG N PR-based concentrated semi-purified FMD mucosal vaccine, were applied. Results of intranasal immunization with the prepared FMD mucosal vaccine, given once or twice, induced IgA levels in both nasal and salivary secretions besides a high response of lymphocyte proliferation with protection levels reaching 20% and 40%, respectively, in a challenge trial in cattle...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29103239/elevated-levels-of-mir-122-in-serum-may-contribute-to-improved-endothelial-function-and-lower-oncologic-risk-following-bariatric-surgery
#15
Arnon Blum, Hila Yehuda, Nissim Geron, Ari Meerson
BACKGROUND: Weight loss surgery is the most effective treatment for obesity, and it reduces cardiovascular and cancer risk through poorly understood mechanisms. MicroRNAs (miRNAs) are short RNA molecules that regulate the stability and translation of many mRNAs. We hypothesized that levels of specific circulating miRNAs are altered following surgery and may contribute to lower cancer risk. OBJECTIVES: To investigate the change of miRNA following surgery. METHODS: All patients underwent gastric "sleeve operation"...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29102329/genetic-and-antigenic-characterization-of-serotype-o-fmd-viruses-from-east-africa-for-the-selection-of-suitable-vaccine-strain
#16
Katie Lloyd-Jones, Mana Mahapatra, Sasmita Upadhyaya, David J Paton, Aravindh Babu, Geoff Hutchings, Satya Parida
Foot-and-mouth disease (FMD) is endemic in Eastern Africa with circulation of multiple serotypes of the virus in the region. Most of the outbreaks are caused by serotype O followed by serotype A. The lack of concerted FMD control programmes in Africa has provided little incentive for vaccine producers to select vaccines that are tailored to circulating regional isolates creating further negative feedback to deter the introduction of vaccine-based control schemes. In this study a total of 80 serotype O FMD viruses (FMDV) isolated from 1993 to 2012 from East and North Africa were characterized by virus neutralisation tests using bovine antisera to three existing (O/KEN/77/78, O/Manisa and O/PanAsia-2) and three putative (O/EA/2002, O/EA/2009 and O/EA/2010) vaccine strains and by capsid sequencing...
November 1, 2017: Vaccine
https://www.readbyqxmd.com/read/29101171/high-intensity-interval-exercise-attenuates-but-does-not-eliminate-endothelial-dysfunction-after-a-fast-food-meal
#17
Wesley J Tucker, Brandon J Sawyer, Catherine L Jarrett, Dharini M Bhammar, Justin R Ryder, Siddhartha S Angadi, Glenn A Gaesser
We investigated whether two different bouts of high-intensity interval exercise (HIIE) could attenuate postprandial endothelial dysfunction. Thirteen young (27 ± 1 yr), non-exercise-trained men underwent 3 randomized conditions: (1) HIIE 4x4: four 4-min intervals at 85-95% of maximum heart rate (HRmax) separated by 3 min active recovery, (2) HIIE 16x1: 16 1-min intervals at 85%-95% of HRmax separated by 1 min active recovery, and (3) sedentary control. HIIE was performed in the afternoon, ~18 h prior to the morning fast-food meal (1250 kcal, 63g fat)...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29098086/effect-of-exercise-intervention-on-flow-mediated-dilation-in-overweight-and-obese-adults-meta-analysis
#18
REVIEW
Younsun Son, Kyungun Kim, Soeun Jeon, Minsoo Kang, Sukho Lee, Yoonjung Park
The objective of this meta-analysis is to summarize the effect of exercise intervention on flow-mediated dilatation (FMD) in overweight and obese adults. We searched four electronic databases (PubMed/Medline, Scopus, and CINAHL) through June 2016 for relevant studies pertaining to the effectiveness of exercise intervention on FMD. Seventeen of the 91 studies identified met the inclusion criteria. Comprehensive Meta-Analysis software (version 3) was used to compute the standardized mean difference effect size (ES) and 95% CI using a random effects model...
2017: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/29095241/effects-of-cerebral-blood-flow-and-vessel-conditions-on-speech-recognition-in-patients-with-postlingual-adult-cochlear-implant-predictable-factors-for-the-efficacy-of-cochlear-implant
#19
Takashi Ishino, Mahmoud Ali Ragaee, Tatsuya Maruhashi, Masato Kajikawa, Yukihito Higashi, Toru Sonoyama, Sachio Takeno, Katsuhiro Hirakawa
OBJECTIVES: Cochlear implantation (CI) has been the most successful procedure for restoring hearing in a patient with severe and profound hearing loss. However, possibly owing to the variable brain functions of each patient, its performance and the associated patient satisfaction are widely variable. The authors hypothesize that peripheral and cerebral circulation can be assessed by noninvasive and globally available methods, yielding superior presurgical predictive factors of the performance of CI in adult patients with postlingual hearing loss who are scheduled to undergo CI...
October 31, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29093276/alpha-2-macroglobulin-as-a-promising-biological-marker-of-endothelial-function
#20
Ryo Shimomura, Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Takamichi Sugimoto, Naoto Kinoshita, Mutsuko Araki, Tetsuya Takahashi, Hirofumi Maruyama, Masayasu Matsumoto
AIMS: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors. METHODS: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70...
November 1, 2017: Journal of Atherosclerosis and Thrombosis
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