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https://www.readbyqxmd.com/read/29788255/reproductive-hormones-and-subclinical-cardiovascular-disease-in-midlife-women
#1
Rebecca C Thurston, Shalender Bhasin, Yuefang Chang, Emma Barinas Mitchell, Karen A Matthews, Ravi Jasuja, Nanette Santoro
Context: Reproductive hormones are understood to be important to the pathophysiology of cardiovascular disease (CVD) in women. However, standard estradiol (E2) and testosterone (T) assays lack sensitivity at the levels of postmenopausal women. Objective: Investigate relations of mass spectrometry-assessed estrone (E1), estradiol (E2), and testosterone (T), and sex hormone binding globulin (SHBG) and subclinical CVD in women. Design, Setting, Participants: 304 peri- and postmenopausal women, aged 40-60 years, and free of clinical CVD underwent subclinical CVD measurements...
May 18, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29786519/effect-of-vaccination-on-cattle-subclinically-infected-with-foot-and-mouth-disease-virus-in-cameroon
#2
Miranda R Bertram, Amy Delgado, Steven J Pauszek, George R Smoliga, Barbara Brito, Carolina Stenfeldt, Ethan J Hartwig, Simon Dickmu Jumbo, Mamoudou Abdoulmoumini, Amba Abona Oliva Marie, Robert Salhine, Luis L Rodriguez, Rebecca Garabed, Jonathan Arzt
Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29785893/evaluating-vaccination-strategies-to-control-foot-and-mouth-disease-a-country-comparison-study
#3
T G Rawdon, M G Garner, R L Sanson, M A Stevenson, C Cook, C Birch, S E Roche, K A Patyk, K N Forde-Folle, C Dubé, T Smylie, Z D Yu
Vaccination is increasingly being recognised as a potential tool to supplement 'stamping out' for controlling foot-and-mouth disease (FMD) outbreaks in non-endemic countries. Infectious disease simulation models provide the opportunity to determine how vaccination might be used in the face of an FMD outbreak. Previously, consistent relative benefits of specific vaccination strategies across different FMD simulation modelling platforms have been demonstrated, using a UK FMD outbreak scenario. We extended this work to assess the relative effectiveness of selected vaccination strategies in five countries: Australia, New Zealand, the USA, the UK and Canada...
May 22, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29785503/prolonged-forearm-ischemia-attenuates-endothelium-dependent-vasodilatation-and-plasma-nitric-oxide-metabolites-in-overweight-middle-aged-men
#4
Zainie Aboo Bakkar, Jonathan Fulford, Phillip E Gates, Sarah R Jackman, Andrew M Jones, Bert Bond, Joanna L Bowtell
PURPOSE: Repeated cycles of endothelial ischemia-reperfusion injury and the resulting respiratory burst contribute to the irreversible pathophysiology of vascular diseases, and yet, the effects of ischemia reperfusion on vascular function, oxidative stress, and nitric oxide (NO) bioavailability have not been assessed simultaneously. Therefore, this study sought to examine the effects of prolonged forearm occlusion and subsequent reperfusion on NO-dependent brachial artery endothelial function...
May 21, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29783067/motor-retraining-more-for-functional-movement-disorders-outcomes-from-a-one-week-multidisciplinary-rehabilitation-program
#5
Alexandra Jacob, Darryl Kaelin, Abbey Roach, Craig Ziegler, Kathrin LaFaver
BACKGROUND: Functional Movement Disorders (FMD) are conditions of abnormal motor control thought to be caused by psychological factors. These disorders are commonly seen in neurological practice and prognosis is often poor. No consensus treatment guidelines have been established, however the role of physical therapy in addition to psychotherapy has increasingly been recognized. This study reports patient outcomes from a multidisciplinary FMD treatment program using motor retraining (MoRe) strategies...
May 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29776753/genetic-and-antigenic-relationship-of-foot-and-mouth-disease-virus-serotype-o-isolates-with-the-vaccine-strain-o1-bfs
#6
Wanhong Xu, Zhidong Zhang, Charles Nfon, Ming Yang
Foot-and-mouth disease serotype O viruses (FMDV/O) are responsible for the most outbreaks in FMD endemic countries. O1/BFS is one of the recommended FMD/O vaccine strains by World Reference Laboratory for FMD. In the current study, FMDV/O1 BFS vaccine strain and serotype O field isolates (45) were analyzed phylogenetically and antigenically to gain more insight into the genetic and antigenic characteristics of the vaccine strain and field isolates. O1/BFS showed similarity with 89% of the field isolates using a virus neutralization test (VNT)...
May 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29773079/effects-of-linagliptin-on-endothelial-function-and-postprandial-lipids-in-coronary-artery-disease-patients-with-early-diabetes-a-randomized-placebo-controlled-double-blind-trial
#7
Norbert J Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner, Harald Sourij
BACKGROUND: Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on a set of cardiovascular surrogate measurements...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29771429/the-relationship-between-number-and-function-of-epcs-and-concentration-of-vegf165-and-sdf-1-in-coronary-artery-spasm
#8
Z-Q Sheng, Y-F Li, K-L Zheng, H-H Lu, J Xie, H Wu, B Xu
OBJECTIVE: We aimed at investigating the functions of endothelial progenitor cells (EPCs) in the pathophysiology of coronary artery spasm (CAS) and coronary artery disease (CAD), as well as to evaluate the correlation of these diseases with the number and function of EPCs, the plasma concentration of vascular endothelial growth factor 165 (VEGF165) and stromal cell-derived factor 1 (SDF-1). PATIENTS AND METHODS: Participants were recruited into three groups, CAS, CAD and the control...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770748/the-effect-of-switching-protease-inhibitors-to-raltegravir-on-endothelial-function-in-hiv-infected-patients
#9
Maaike Krikke, Kiki Tesselaar, Guido E L van den Berk, Sigrid A Otto, Laura H Freriks, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman, Joop E Arends
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has a relatively favorable effect on plasma lipids. We examined the effect of switching from PIs to RAL on endothelial function, and its effect on immunological and inflammatory parameters. Methods We performed a 16-week open-label prospective crossover study: 8 weeks intervention (switch PIs to RAL) and 8 weeks control (unchanged cART regimen)...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29760721/decreased-count-and-dysfunction-of-circulating-epcs-in-postmenopausal-hypercholesterolemic-females-via-reducing-no-production
#10
Ying Luo, Quan-Neng Yan, Wan-Zhou Wu, Fan-Yan Luo
Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown. Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29757239/preparation-physicochemical-and-antioxidant-properties-of-acid-and-pepsin-soluble-collagens-from-the-swim-bladders-of-miiuy-croaker-miichthys-miiuy
#11
Wen-Hao Zhao, Chang-Feng Chi, Yu-Qin Zhao, Bin Wang
Collagen is one of the most useful biomaterials and widely applied in functional food and cosmetics. However, some consumers have paid close attention to the safety of mammalian collagens because of the outbreaks of bovine spongiform encephalopathy (BSE), foot-and-mouth disease (FMD), and other prion diseases. Therefore, there is a strong demand for developing alternative sources of collagen, with one promising source being from the process by-products of commercial fisheries. In this report, acid-soluble collagen (ASC-SB) and pepsin-soluble collagen (PSC-SB) from swim bladders of miiuy croaker ( Miichthys miiuy ) were isolated with yields of 1...
May 12, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29755989/assessing-biosecurity-risks-for-the-introduction-and-spread-of-diseases-among-commercial-sheep-properties-in-new-south-wales-australia-using-foot-and-mouth-disease-as-a-case-study
#12
Jake Fountain, Robert Woodgate, Luzia Rast, Marta Hernández-Jover
Sheep production systems are a major industry in Australia, with a gross value of roughly $4.66 billion; 87.3% of which is attributable to export markets. Exotic diseases such as foot-and-mouth disease (FMD) are a potential threat to the viability of Australia's export market. Previous outbreaks of FMD in developed countries, and challenges in the management of onshore biosecurity, signify the importance of on-farm biosecurity in controlling disease transmission. This study aims to investigate the risk of disease introduction and spread among New South Wales (NSW) sheep properties using FMD as a case study and draw recommendation for the industry...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29754930/new-assessment-of-endothelial-function-measured-by-short-time-flow-mediated-vasodilation-comparison-with-conventional-flow-mediated-vasodilation-measurement
#13
Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Haruki Hashimoto, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Farina Mohamad Yusoff, Shinji Kishimoto, Ayumu Nakashima, Kensuke Noma, Tomohiro Kawaguchi, Takeo Matsumoto, Yukihito Higashi
BACKGROUND: Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endothelial dysfunction, and clinical implications including effects of interventions and cardiovascular events. To shorten and simplify the measurement of FMD, we have developed a novel technique named short time FMD (stFMD). We investigated the validity of stFMD for assessment of endothelial function compared with conventional FMD...
May 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29748721/impact-of-acute-dynamic-exercise-on-radial-artery-low-flow-mediated-constriction-in-humans
#14
Robert O Elliott, Sultan Alsalahi, James P Fisher
PURPOSE: A "low-flow mediated constriction" (L-FMC) is evoked in the radial artery by the inflation of an ipsilateral wrist cuff to a supra-systolic pressure. We sought to test the hypothesis that the radial artery L-FMC response is augmented immediately following acute dynamic leg exercise in young healthy individuals. METHODS: Ten healthy and recreationally active men (23 ± 4 years) undertook a 30-min trial of incremental dynamic leg cycling exercise (10 min at 50, 100 and 150 W) and a 30-min time control trial (seated rest)...
May 10, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29747515/endocan-levels-and-endothelial-dysfunction-in-patients-with-sarcoidosis
#15
Gonul Aciksari, Murat Kavas, Adem Atici, Seref Kul, Hayriye Erman, Yusuf Yilmaz, Kenan Demircioglu, Emre Yalcinkaya, Asiye Kanbay, Mustafa Caliskan
A systemic inflammatory reaction is a common feature of both sarcoidosis and atherosclerosis. Endothelial-cell specific molecule 1 (endocan) is a marker of vascular pathology which also shows a correlation with inflammation, endothelial dysfunction, and atherosclerosis. The objective of this study was to evaluate the vascular involvement in sarcoidosis using serum endocan levels and brachial artery flow-mediated dilation (FMD), a marker of endothelial dysfunction. We included 53 patients with sarcoidosis without conventional cardiovascular risk factors and 40 healthy controls...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29745040/first-detection-of-foot-and-mouth-disease-virus-o-me-sa-ind2001-in-china
#16
Z Zhu, F Yang, J He, J Li, W Cao, J Li, Y Xia, J Guo, Y Jin, K Zhang, H Zheng, X Liu
Foot-and-mouth disease (FMD) is endemic in China and is predominantly due to foot-and-mouth disease virus (FMDV) serotype O Mya-98 lineage. In recent years, FMDV O/ME-SA/Ind2001 lineage has spread from the Indian subcontinent to South-East Asia, Middle East and Africa, which may pose potential threats for future trans-regional livestock movements. In this study, we identified the appearance of FMDV O/ME-SA/Ind2001 in China; the first time that this virus lineage has been found there. Sequencing and phylogenetic analysis of VP1 sequences revealed that this newly determined strain belongs to O/ME-SA/Ind2001 sublineage d and is closely related to strains that have caused recent outbreaks of FMD in Nepal, Myanmar, Russia and South Korea...
May 9, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29740345/conduit-artery-diameter-during-exercise-is-enhanced-after-local-but-not-remote-ischemic-preconditioning
#17
Scott Cocking, N T Cable, Mathew G Wilson, Daniel J Green, Dick H J Thijssen, Helen Jones
Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise. Methods: Eighteen healthy, recreationally trained, male participants (mean ± SD : age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1 ) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29739239/total-hip-replacement-provokes-endothelial-dysfunction
#18
Peter Poredos, Ana Mavric, Lara Leben, Pavel Poredos, Mateja Kaja Jezovnik
Surgery represents an increased risk of different perioperative complications. Endothelial function (EF) is a key mechanism responsible for cardiovascular homeostasis and is involved in thromboembolic complications. We aimed to follow changes of EF in an early postoperative period in patients undergoing total hip replacement (THR). Endothelial function was assessed noninvasively in 70 consecutive patients who underwent an elective THR under spinal anesthesia. Flow-mediated dilation (FMD) and low flow-mediated constriction capability of the brachial artery, which are indicators of EF were measured before the operation (baseline), 24 hours after the operative procedure, and 5 to 7 days postoperatively...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29735325/alternate-vaccine-strain-selection-in-the-wake-of-emerging-foot-and-mouth-disease-virus-serotype-a-antigenic-variants-in-india
#19
Jajati Keshari Mohapatra, Biswajit Das, Manoranjan Rout, B P Sreenivasa, Saravanan Subramaniam, Aniket Sanyal, Bramhadev Pattnaik
'National foot-and-mouth disease (FMD) control programme' is being implemented in India and therefore predicting vaccine match is a key surveillance task. Recently, a considerable proportion of field viruses (75.6%) showed antigenic drift from the existing serotype A vaccine strain A IND 40/2000 necessitating search for an alternate strain. Here, antigenic relationship ('r1 ' value) of 87 field viruses with each of the 8 candidate strains was estimated by virus neutralization test. A IND 27/2011 strain emerged to be the one with the widest spectrum of antigenic coverage showing 'r1 ' value of more than 0...
May 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29728052/a-new-method-for-the-assessment-of-endothelial-function-with-peripheral-arterial-volume
#20
Daoyuan Si, Lujia Ni, Yunfei Wang, Jinsha Liu, Jining Yang, Ping Yang
BACKGROUND: Currently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial function is still required. We evaluated the potential value of a new method to measure peripheral endothelial function with reactive hyperemia peripheral arterial volume (RH-PAV) in patients with chest pain. METHODS: We used a novel oximeter-like probe to detect the peripheral arterial volume (PAV) of the finger and compared it with brachial flow-mediated dilation (FMD) performed in 93 consecutive patients with chest pain...
May 4, 2018: BMC Cardiovascular Disorders
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