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https://www.readbyqxmd.com/read/29334477/improvement-of-endothelial-function-by-pitavastatin-a-meta-analysis
#1
Niki Katsiki, Željko Reiner, Eugenia Tedeschi Reiner, Khalid Al-Rasadi, Matteo Pirro, Dimitri P Mikhailidis, Amirhossein Sahebkar
OBJECTIVE: Dyslipidemia is commonly associated with endothelial dysfunction and increased cardiovascular risk. Pitavastatin has been shown to reduce total and low-density lipoprotein cholesterol, to increase high-density lipoprotein (HDL)-cholesterol and improve HDL function. Furthermore, several trials explored its effects on flow-mediated dilation (FMD), as an index of endothelial function. The authors evaluated the effect of pitavastatin therapy on FMD. METHODS: The authors performed a systematic review and meta-analysis of all clinical trials exploring the impact of pitavastatin on FMD...
January 15, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29333218/impact-of-mindfulness-based-stress-reduction-therapy-on-myocardial-function-and-endothelial-dysfunction-in-female-patients-with-microvascular-angina
#2
Bong Joon Kim, In Suk Cho, Kyoung Im Cho
Background: Mindfulness-based stress reduction (MBSR) is a structured group program that employs mindfulness meditation to alleviate suffering associated with physical, psychosomatic, and psychiatric disorders. In this study, we investigate the impact of MBSR on left ventricular (LV) and endothelial function in female patients with microvascular angina. Methods: A total of 34 female patients (mean age 52.2 ± 13.8 years) diagnosed with microvascular angina underwent a MBSR program with anti-anginal medication for 8 weeks...
December 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29330660/theobromine-consumption-does-not-improve-fasting-and-postprandial-vascular-function-in-overweight-and-obese-subjects
#3
Lotte Smolders, Ronald P Mensink, Jose J van den Driessche, Peter J Joris, Jogchum Plat
BACKGOUND: Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE: To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers. DESIGN: In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks...
January 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29330436/blood-transcriptomics-of-captive-forest-musk-deer-moschus-berezovskii-and-possible-associations-with-the-immune-response-to-abscesses
#4
Xiaoning Sun, Ruibo Cai, Xuelin Jin, Aaron B A Shafer, Xiaolong Hu, Shuang Yang, Yimeng Li, Lei Qi, Shuqiang Liu, Defu Hu
Forest musk deer (Moschus berezovskii; FMD) are both economically valuable and highly endangered. A problem for FMD captive breeding programs has been the susceptibility of FMD to abscesses. To investigate the mechanisms of abscess development in FMD, the blood transcriptomes of three purulent and three healthy individuals were generated. A total of ~39.68 Gb bases were generated using Illumina HiSeq 4000 sequencing technology and 77,752 unigenes were identified after assembling. All the unigenes were annotated, with 63,531 (81...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329924/effects-of-dark-chocolate-on-endothelial-function-in-patients-with-non-alcoholic-steatohepatitis
#5
L Loffredo, F Baratta, P Ludovica, S Battaglia, R Carnevale, C Nocella, M Novo, G Pannitteri, F Ceci, F Angelico, F Violi, M Del Ben
BACKGROUND AND AIM: Oxidative stress plays a pivotal role in inducing endothelial dysfunction and progression from simple fatty liver steatosis (FLD) to non-alcoholic steatohepatitis (NASH). Polyphenols could reduce oxidative stress and restore endothelial function by inhibiting the nicotinamide-adenine-dinucleotide-phosphate (NADPH) oxidase isoform Nox2. The aim of this study was to assess endothelial function and oxidative stress in a population affected by simple FLD and NASH. Furthermore, we analysed the effect of high vs low content of cocoa polyphenols on endothelial function and oxidative stress in patients with NASH...
November 13, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29322080/data-on-a-single-oral-dose-of-camu-camu-myrciaria-dubia-pericarp-extract-on-flow-mediated-vasodilation-and-blood-pressure-in-young-adult-humans
#6
Tadayoshi Miyashita, Ryosuke Koizumi, Takao Myoda, Yoshimasa Sagane, Koichi Niwa, Toshihiro Watanabe, Kazuhiro Minami
This data article describes the flow-mediated vasodilation (FMD) responses, represented by changes in arterial diameter, and blood pressure changes in young adults after a single oral dose of camu camu (Myrciaria dubia) pericarp extract or placebo (cross-over design). Ten healthy men and 10 healthy women participated in this study. Ultrasonic diagnostic equipment was used to monitor arterial diameter changes, indicative of FMD, for 110 s after the administration of the camu camu extract or placebo. In addition, the systolic and diastolic blood pressure values were recorded...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29319602/an-interactional-profile-to-assist-the-differential-diagnosis-of-neurodegenerative-and-functional-memory-disorders
#7
Markus Reuber, Daniel J Blackburn, Chris Elsey, Sarah Wakefield, Kerry A Ardern, Kirsty Harkness, Annalena Venneri, Danielle Jones, Chloe Shaw, Paul Drew
OBJECTIVE: Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behavior of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with functional memory disorder (FMD). METHODS: In part 1 of this study, a diagnostic scoring aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29317976/postpartum-sudden-cardiac-death-after-spontaneous-coronary-artery-dissection-in-a-patient-with-fibromuscular-dysplasia
#8
Tannaz Shoja, Craig Basman, Suresh Jain, Aditya Mangla, Zoran Lasic
Spontaneous coronary artery dissection (SCAD) is a rare entity that can cause acute myocardial infarction and sudden cardiac death (SCD) which often goes unrecognized. We report a case of SCAD in a young postpartum female who presented with sudden cardiac arrest. The patient was managed medically and found to have fibromuscular dysplasia (FMD). After being stabilized in the critical care unit, coronary angiography was performed which showed dissection of the left main artery, intramural hematoma, and the culprit lesion...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29317918/awareness-of-the-implementation-of-the-falsified-medicines-directive-among-pharmaceutical-companies-professionals-in-the-european-economic-area
#9
Urszula WŁodarczak, Damian Swieczkowski, Urszula Religioni, Milosz Jaguszewski, Jerzy Krysinski, Piotr Merks
Background: The Falsified Medicines Directive (FMD) is a response of the European Union to the increasing number of falsified medicines present in the legal supply chain within the Member States of the community. Effective implementation of the new regulations will depend on the effective cooperation of all parties involved in the distribution of medicinal products including the managers of pharmaceutical companies. Objective: The objective of the study was to examine awareness of the Implementation of the FMD among pharmaceutical company professionals in the European Economic Area...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29313572/cardio-metabolic-risk-profile-in-women-with-previous-history-of-pre-eclampsia
#10
Jalees Fatma, Ritu Karoli, Zeba Siddiqui, H P Gupta, Ashok Chandra, Mahima Pandey
Introduction: Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality. However there is growing evidence that there are differences during the post partum period between subjects with prior preeclampsia and prior uncomplicated pregnancy and women with a history of preeclampsia are more likely to develop cardiovascular disease later in life. The aim of our study was to assess the cardio- metabolic risk profile in women with previous history of pre-eclampsia and to their counterparts who had normal pregnancy...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29313571/a-study-of-endothelial-dysfunction-in-patients-of-non-alcoholic-fatty-liver-disease
#11
Vaibhav Shukla, Jalees Fatima, Saurabh Chaudhary, Mohsin Ali, Ishan Mishra
Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide rapidly and is regarded as the hepatic manifestation of metabolic syndrome. The present study was undertaken to study the endothelial dysfunction by flow mediated vasodilatation in NAFLD patients. Material & Methods: 32 cases and 16 age and sex matched controls were included in the study. Flow mediated vasodilatation of the brachial artery was studied in both cases and controls...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29310645/effects-of-6-month-treatment-with-the-glucagon-like-peptide-1-analogue-liraglutide-on-arterial-stiffness-left-ventricular-myocardial-deformation-and-oxidative-stress-in-subjects-with-newly-diagnosed-type-2-diabetes
#12
Vaia Lambadiari, George Pavlidis, Foteini Kousathana, Maria Varoudi, Dimitrios Vlastos, Eirini Maratou, Dimitrios Georgiou, Ioanna Andreadou, John Parissis, Helen Triantafyllidi, John Lekakis, Efstathios Iliodromitis, George Dimitriadis, Ignatios Ikonomidis
BACKGROUND: Incretin-based therapies are used in the treatment of type 2 diabetes mellitus (T2DM) and obesity. We investigated the changes in arterial stiffness and left ventricular (LV) myocardial deformation after 6-month treatment with the GLP-1 analogue liraglutide in subjects with newly diagnosed T2DM. METHODS: We randomized 60 patients with newly diagnosed and treatment-naive T2DM to receive either liraglutide (n = 30) or metformin (n = 30) for 6 months...
January 8, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29309832/vascular-function-and-cholecalciferol-supplementation-in-ckd-a-self-controlled-case-series
#13
Vivek Kumar, Ashok Kumar Yadav, Manphool Singhal, Vinod Kumar, Anupam Lal, Debasish Banerjee, Krishan Lal Gupta, Vivekanand Jha
Vitamin D deficiency is common and associated with mortality in chronic kidney disease (CKD) patients. Cardiovascular disease (CVD) is the commonest cause of mortality in CKD patients. In a randomized, double blind, placebo controlled trial, we have recently reported favorable effects of vitamin D supplementation on vascular & endothelial function and inflammatory biomarkers in vitamin D deficient patients with non-diabetic stage 3-4 CKD (J Am Soc Nephrol 28: 3100-3108, 2017). Subjects in the placebo group who had still not received vitamin D after completion of the trial received two oral doses 300000 IU of oral cholecalciferol at 8 weeks interval followed by flow mediated dilatation (FMD), pulse wave velocity (PWV), circulating endothelial and inflammatory markers (E-Selectin, vWF, hsCRP and IL-6), 1,25 (OH)2D, iPTH and iFGF-23 assessment at 16 weeks...
January 5, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29290295/financial-impact-of-foot-and-mouth-disease-outbreaks-on-pig-farms-in-the-republic-of-korea-2014-2015
#14
Hachung Yoon, Wooseog Jeong, Jun-Hee Han, Jida Choi, Yong-Myung Kang, Yong-Sang Kim, Hong-Sig Park, Tim E Carpenter
The financial impact of foot-and-mouth disease (FMD) that occurred in 180 piggeries (100 farrow-to-finish and 80 fattening farms) confirmed infected during the 2014/2015 epidemic in the Republic of Korea was estimated at the farm level. The median loss due to slaughtering of pigs prior to their expected market weights was US$ 71.8 (uncovered compensation-compensation loss) plus US$ 57.3 (foregone net gain) per pig. Median loss per farm was US$ 27,487 (55.6% of total loss) for compensation and US$ 15,925 (44...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29288864/assessment-of-subclinical-atherosclerosis-in-systemic-lupus-erythematosus-a-systematic-review-and-meta-analysis
#15
Pauline Henrot, Jennifer Foret, Thomas Barnetche, Estibaliz Lazaro, Pierre Duffau, Julien Seneschal, Thierry Schaeverbeke, Marie-Elise Truchetet, Christophe Richez
OBJECTIVES: To determine whether subclinical atherosclerosis is increased in patients with systemic lupus erythematosus (SLE) compared to healthy individuals, using carotid intima-media thickness (CIMT), carotid plaque (CP) presence or flow-mediated dilatation (FMD). METHODS: A systematic literature search was performed using MedLine, Embase and Cochrane databases. Two reviewers independently screened the articles to identify studies that compared the rates of atherosclerosis in SLE patients versus healthy controls...
December 27, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29288632/association-of-vascular-indices-with-novel-circulating-biomarkers-as-prognostic-factors-for-cardiovascular-complications-in-patients-with-type-2-diabetes-mellitus
#16
Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Sophia Antoniou, Nikolaos Kazakos, Alexandra Margeli, Ioannis Papassotiriou, Agathocles Tsatsoulis, Lampros K Michalis
BACKGROUND: The pathophysiology of atherosclerosis in type 2 diabetes mellitus (T2DM) is multifactorial. The association of vascular indices with circulating biomarkers of inflammation and insulin resistance and their role in the long-term cardiovascular prognosis in T2DM patients were currently investigated. PATIENTS AND METHODS: Patients with T2DM and poor glycemic control without known cardiovascular diseases (n=119) at baseline were enrolled and followed for about 9years...
December 27, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29288158/interrelationships-among-flow-mediated-vasodilation-nitroglycerine-induced-vasodilation-baseline-brachial-artery-diameter-hyperemic-shear-stress-and-cardiovascular-risk-factors
#17
Tatsuya Maruhashi, Yumiko Iwamoto, Masato Kajikawa, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Eisuke Hida, Yukihito Higashi
BACKGROUND: Flow-mediated vasodilation (FMD) of the brachial artery has been used for the assessment of endothelial function. Considering the mechanism underlying the vasodilatory response of the brachial artery to reactive hyperemia, hyperemic shear stress (HSS), a stimulus for FMD; nitroglycerine-induced vasodilation (NID), an index of endothelium-independent vasodilation; and baseline brachial artery diameter (BAD) are also involved in vasodilatory response. The purpose of this study was to investigate the interrelationships among FMD, HSS, NID, baseline BAD, and cardiovascular risk factors...
December 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29281189/influence-of-hyperoxia-on-diastolic-myocardial-and-arterial-endothelial-function
#18
T Wunderlich, N Frey, W Kähler, M Lutz, P Radermacher, S Klapa, I Koch, F Tillmans, J Witte, A Koch
OBJECTIVE: Hyperoxia is known to influence cardiovascular and endothelial function, but it is unknown if there are differences between younger and older persons. The aim of this study was to monitor changes in myocardial diastolic function and flow-mediated dilatation (FMD) in younger and elderly volunteers, before and after exposure to relevant hyperbaric hyperoxia. METHODS: 51 male patients were separated into two groups for this study. Volunteers in Group 1 (n=28, mean age 26 ±6, "juniors") and Group 2 (n=23, mean age 53 ±9, "seniors") received standard HBO₂ protocol (240kPa oxygen)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29275928/spontaneous-coronary-artery-dissection-scad-the-underdiagnosed-cardiac-condition-that-plagues-women
#19
REVIEW
Sandrine Lebrun, Rachel M Bond
Coronary heart disease (CHD) continues to be understudied, underdiagnosed, and undertreated in women. Gender and age bias complicate the evaluation of women with acute coronary syndrome (ACS). As a result, conditions like spontaneous coronary artery dissection (SCAD) are often missed. SCAD is an infrequent yet important cause of myocardial infarction (MI) with a predilection for young to middle aged women. The condition is thought to be under-reported, likely a result of both low index of suspicion as well as an unfamiliarity with SCAD's angiographic variants...
December 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29274507/mediterranean-diet-improves-endothelial-function-in-patients-with-diabetes-and-prediabetes-a-report-from-the-cordioprev-study
#20
Jose D Torres-Peña, Antonio Garcia-Rios, Nieves Delgado-Casado, Purificacion Gomez-Luna, Juan F Alcala-Diaz, Elena M Yubero-Serrano, Francisco Gomez-Delgado, Ana Leon-Acuña, Javier Lopez-Moreno, Antonio Camargo, Francisco J Tinahones, Javier Delgado-Lista, Jose M Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda
BACKGROUND AND AIMS: Endothelial dysfunction (ED) plays a key role in the development of atherosclerotic cardiovascular disease (ASCVD). Likewise, type 2 diabetes (T2D) is a major CVD risk factor. Therefore, our objective was to explore whether long-term consumption of a Mediterranean diet (MedDiet) rich in olive oil or a low-fat diet (LF diet) was associated with an improvement in ED and whether the potential benefits were similar in patients with or without T2D in the CORDIOPREV clinical trial (NCT00924937)...
December 8, 2017: Atherosclerosis
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