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https://www.readbyqxmd.com/read/27925154/prenatal-exposure-to-maternal-bereavement-and-offspring-psoriasis-a-danish-nationwide-cohort-study
#1
X Liu, J Chen, J Olsen, V Schlünssen, N Momen, J Li
BACKGROUND: Prenatal stress may alter immune competence of the foetus. Limited data exist on the role of antenatal stress in psoriasis development. We aimed to investigate whether prenatal exposure to maternal bereavement increased the risk of offspring psoriasis. METHODS: This register-based cohort study included 1,811,917 live singletons born 1978-2008 in Denmark. The children were assigned to the bereaved group if their mothers lost a child, partner/spouse, a parent or a sibling during pregnancy or up to 12 months before pregnancy...
December 7, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27896921/effect-of-iron-supplementation-during-lactation-on-maternal-iron-status-and-oxidative-stress-a-randomized-controlled-trial
#2
Josh M Jorgensen, Zhenyu Yang, Bo Lönnerdal, Caroline J Chantry, Kathryn G Dewey
We examined the effect of iron-containing prenatal vitamin-mineral supplements taken postpartum on biomarkers of iron status and oxidative stress. Lactating women (n = 114) were randomly assigned to consume daily one iron-free prenatal vitamin-mineral supplement plus either 27 mg of iron or placebo for approximately 3.5 months. The placebo group took the tablets between meals, while those given iron took the tablets either with (Fe-W) or between meals (Fe-B). Blood and urine samples were collected before and after the supplementation period to analyze hemoglobin (Hb), ferritin, hepcidin, transferrin saturation (TfSat), total plasma iron, and biomarkers of oxidative stress (isoprostane and 8-hydroxy-2-deoxyguanosine (8-OHdG)) and inflammation (C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP))...
November 29, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27883060/environmental-intervention-as-a-therapy-for-adverse-programming-by-ancestral-stress
#3
J Keiko McCreary, Zachary T Erickson, YongXin Hao, Yaroslav Ilnytskyy, Igor Kovalchuk, Gerlinde A S Metz
Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerationally heritable endocrine and epigenetic footprint and elevated stress sensitivity which can be alleviated by beneficial experiences in later life. Ancestral stress led to downregulated glucocorticoid receptor and prefrontal cortex neuronal densities along with precocious development of anxiety-like behaviours...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879500/implications-of-preterm-birth-for-maternal-mental-health-and-infant-development
#4
Cheryl Anderson, Priscila Cacola
Preterm birth remains a major contributor to infant mortality and morbidity including neurodevelopmental delay and childhood disability. Mothers experiencing a preterm birth are at risk for maternal mental health issues, inclusive of depression and posttraumatic stress disorder (PTSD), which may affect mother-infant attachment and infant development. Depression and PTSD, frequently comorbid, following preterm birth and relationships between these symptoms, maternal-infant attachment, and infant development are reviewed...
November 22, 2016: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27870297/household-financial-distress-and-initial-endowments-evidence-from-the-2008-financial-crisis
#5
Arna Olafsson
This paper studies in utero exposure to the 2008 financial crisis. Exploiting the sudden and unexpected collapse of the Icelandic economy, I find that first-trimester exposure to the crisis led to a sizable and significant reduction in birth weight, increased the probability of a low birth weight ( < 2500 g), and decreased the probability of a high birth weight ( > 4000 g). I also find evidence that the collapse reduced the sex ratio, indicating selection in utero due to maternal prenatal stress exposure...
November 2016: Health Economics
https://www.readbyqxmd.com/read/27865585/the-prevalence-of-posttraumatic-stress-disorder-in-pregnancy-and-after-birth-a-systematic-review-and-meta-analysis
#6
REVIEW
Pelin Dikmen Yildiz, Susan Ayers, Louise Phillips
BACKGROUND: Previous reviews have provided preliminary insights into risk factors and possible prevalence of Post-traumatic Stress Disorder (PTSD) postpartum with no attempt to examine prenatal PTSD. This study aimed to assess the prevalence of PTSD during pregnancy and after birth, and the course of PTSD over this time. METHODS: PsychINFO, PubMed, Scopus and Web of Science were searched using PTSD terms crossed with perinatal terms. Studies were included if they reported the prevalence of PTSD during pregnancy or after birth using a diagnostic measure...
October 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27865525/maternal-stress-modifies-the-effect-of-exposure-to-lead-during-pregnancy-and-24-month-old-children-s-neurodevelopment
#7
Marcela Tamayo Y Ortiz, Martha María Téllez-Rojo, Belem Trejo-Valdivia, Lourdes Schnaas, Erika Osorio-Valencia, Brent Coull, David Bellinger, Rosalind J Wright, Robert O Wright
BACKGROUND: Lead and psychosocial stress disrupt similar but not completely overlapping mechanisms. Exposure during the prenatal period to each of these insults singularly has been found to alter normal neurodevelopment; however, longitudinal associations with stress modifying the effect of lead have not been sufficiently analyzed in epidemiologic studies. OBJECTIVE: To evaluate prenatal stress as an effect modifier of gestational lead neurotoxicity. METHODS: We used a structural equations modeling approach with a trivariate response to evaluate cognitive, language and motor scores of the Bayley Scales of Infant Development-III in 24month-old children (n=360)...
November 16, 2016: Environment International
https://www.readbyqxmd.com/read/27865450/reproductive-function-in-the-sons-of-women-who-experienced-stress-due-to-bereavement-before-and-during-pregnancy-a-nationwide-population-based-cohort-study
#8
Oleguer Plana-Ripoll, Jiong Li, Ulrik Schiøler Kesmodel, Erik Parner, Jørn Olsen, Olga Basso
OBJECTIVE: To estimate the association between prenatal exposure to maternal stress and reproductive disorders in Danish men, where prenatal stress exposure was defined as the mother's loss of a close relative during pregnancy or in the 12 months before conception. DESIGN: Population-based cohort study. SETTING: Not applicable. PATIENT(S): All males born in Denmark between 1973 and 2008 (n = 1,217,576) and observed for up to 39 years...
November 16, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27862088/prognostic-dilemmas-and-genetic-counseling-for-prenatally-detected-fragile-x-gene-expansions
#9
Brenda Finucane, Sharyn Lincoln, Lindsay Bailey, Christa Lese Martin
With widespread adoption of fragile X carrier screening in pregnant women, the number of expectant couples receiving news of an unanticipated Fragile X Mental Retardation 1 (FMR1) gene expansion has increased. The most common abnormal result from maternal FMR1 testing involves an intermediate allele, also known as a gray zone result, which requires genetic counseling but poses minimal risk for an adverse developmental outcome. By contrast, the finding of a maternal FMR1 pre- or full mutation during pregnancy has important implications for the woman herself, her unborn child, and her extended family...
November 11, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27855430/prospective-fathers-psychosocial-adaptation-and-involvement-in-the-last-trimester-of-pregnancy
#10
Karin Kuljanić, Tamara Martinac Dorčić, Ivana Ljubičić Bistrović, Alemka Brnčić-Fischer
BACKGROUND: Paternal involvement in pregnancy has been recognized to have an impact on new-born's outcomes and only recently got under the spot light of mental health perspective. The aim of this study was to test differences in paternal involvement in pregnancy, perceived stress and relationship quality regarding complications in pregnancy and pregnancy duration (gestational weeks) in the last trimester of pregnancy. The role of personality traits (neuroticism and extroversion), relationship quality satisfaction and perceived stress in prospective father's perception of pregnancy involvement were examined...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27853988/antenatal-manifestations-of-inborn-errors-of-metabolism-prenatal-imaging-findings
#11
Laurent Guibaud, Sophie Collardeau-Frachon, Audrey Lacalm, Mona Massoud, Massimiliano Rossi, Marie Pierre Cordier, Christine Vianey-Saban
Prenatal manifestations of inborn errors of metabolism (IEM) are related to severe disorders involving metabolic pathways active in the fetal period and not compensated by maternal or placental metabolism. Some prenatal imaging findings can be suggestive of such conditions-especially in cases of consanguinity and/or recurrence of symptoms-after exclusion of the most frequent nonmetabolic etiologies. Most of these prenatal imaging findings are nonspecific. They include mainly ascites and hydrops fetalis, intrauterine growth restriction (IUGR), central nervous system (CNS) anomalies, echogenic kidneys, epiphyseal stippling, craniosynostosis, and a wide spectrum of dysostoses...
November 16, 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27853327/the-effects-of-maternal-opium-abuse-on-fetal-heart-rate-using-non-stress-test
#12
Fatemeh Keikha, Fahimeh Ghotbizadeh Vahdani, Sahar Latifi
BACKGROUND: Opium is one of the most commonly abused opiates in developing countries including Iran. Considering the importance of maternal health on the newborn, we aimed to assess the effect of opium abuse on fetal heart rate (FHR) characteristics in a sample of pregnant women in Zahedan, Southeast Iran. METHODS: This cross-sectional study was done on 100 pregnant women referring to Ali-Ibn-Abi Talib Hospital in Zahedan, during 2011-2013. The participants were divided into two groups comprising of opium abusers and healthy individuals...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27852943/co-adjustment-of-yolk-antioxidants-and-androgens-in-birds
#13
Mathieu Giraudeau, Simon Ducatez
Mothers can shape the developmental trajectory of their offspring through the transmission of resources such as hormones, antioxidants or immunoglobulins. Over the last two decades, an abundant literature on maternal effects in birds has shown that several of these compounds (i.e. androgens, glucocorticoids and antioxidants) often influence the same offspring phenotypic traits (i.e. growth, immunity or oxidative stress levels), making interaction effects between egg components a likely scenario. However, the potential interactive effects of maternally transmitted compounds on offspring development and potential co-adjustment of these compounds within an egg are still poorly understood...
November 2016: Biology Letters
https://www.readbyqxmd.com/read/27843010/identifying-sensitive-windows-for-prenatal-particulate-air-pollution-exposure-and-mitochondrial-dna-content-in-cord-blood
#14
Maria José Rosa, Allan C Just, Marco Sánchez Guerra, Itai Kloog, Hsiao-Hsien Leon Hsu, Kasey J Brennan, Adriana Mercado García, Brent Coull, Rosalind J Wright, Martha María Téllez Rojo, Andrea A Baccarelli, Robert O Wright
INTRODUCTION: Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM2.5 exposure using mtDNA content measured in cord blood. MATERIAL AND METHODS: Women affiliated with the Mexican social security system were recruited during pregnancy in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study...
January 2017: Environment International
https://www.readbyqxmd.com/read/27826783/predictors-of-postpartum-depression-in-partnered-mothers-and-fathers-from-a-longitudinal-cohort
#15
Brenda M Y Leung, Nicole L Letourneau, Gerald F Giesbrecht, Henry Ntanda, Martha Hart
Postpartum depression (PPD) is a growing mental health concern in new mothers and fathers. The purpose of this study was to determine the predictors of depression at 3 months postpartum, comparing depressed couples to couples with only one depressed partner or no depressed partner, using data from the Alberta Pregnancy Outcomes and Nutrition study. Data from mothers and fathers were collected at second trimester and 3 months postpartum. Results showed predictors of PPD in mothers to be low household income, high prenatal depressive symptoms, and postnatally, low social support and higher number of stressful life events...
November 8, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27825840/environmental-toxicology-sensitive-periods-of-development-and-neurodevelopmental-disorders
#16
REVIEW
Djai B Heyer, Rhiannon M Meredith
Development of the mammalian central nervous system is a complex process whose disruption may have severe and long-lasting consequences upon brain structure and function, potentially resulting in a neurodevelopmental disorder (NDD). Many NDDs are known to be genetic in origin, with symptom onset and their underlying mechanisms now known to be regulated during time-dependent windows or 'critical periods' during normal brain development. However, it is increasingly evident that similar disturbances to the developing nervous system may be caused by exposure to non-genetic, environmental factors...
November 4, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27824361/ankyrin-3-as-a-molecular-marker-of-early-life-stress-and-vulnerability-to-psychiatric-disorders
#17
A Luoni, R Massart, V Nieratschker, Z Nemoda, G Blasi, M Gilles, S H Witt, M J Suderman, S J Suomi, A Porcelli, G Rizzo, L Fazio, S Torretta, A Rampino, A Berry, P Gass, F Cirulli, M Rietschel, A Bertolino, M Deuschle, M Szyf, M A Riva
Exposure to early-life stress (ELS) may heighten the risk for psychopathology at adulthood. Here, in order to identify common genes that may keep the memory of ELS through changes in their methylation status, we intersected methylome analyses performed in different tissues and time points in rats, non-human primates and humans, all characterized by ELS. We identified Ankyrin-3 (Ank3), a scaffolding protein with a strong genetic association for psychiatric disorders, as a gene persistently affected by stress exposure...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27823722/relationship-between-prenatal-maternal-stress-and-sleep-quality-in-chinese-pregnant-women-the-mediation-effect-of-resilience
#18
Guopeng Li, Linghua Kong, Haiyan Zhou, Xiaofei Kang, Yueyan Fang, Ping Li
OBJECTIVE: To examine the relationship between prenatal maternal stress, resilience, and sleep quality, and to determine whether resilience plays a mediating role in the relationship between prenatal maternal stress and sleep quality among pregnant women. METHODS: Two hundred and thirty-one pregnant women in their second trimester participated in the study. They completed questionnaires, including: the Pittsburgh Sleep Quality Index (PSQI), the Pregnancy Stress Rating Scale (PSRS), and the 10-item Connor-Davidson Resilience Scale (CD-RISC-10)...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27822638/cardiac-changes-in-apoptosis-inflammation-oxidative-stress-and-nitric-oxide-system-induced-by-prenatal-and-postnatal-zinc-deficiency-in-male-and-female-rats
#19
Lorena Vanesa Juriol, María Natalia Gobetto, Facundo Mendes Garrido Abregú, Marina Ercilia Dasso, Gonzalo Pineda, Leandro Güttlein, Andrea Carranza, Osvaldo Podhajcer, Jorge Eduardo Toblli, Rosana Elesgaray, Cristina Teresa Arranz, Analía Lorena Tomat
PURPOSE: Zinc restriction during fetal and postnatal development could program cardiovascular diseases in adulthood. The aim of this study was to determine the effects of zinc restriction during fetal life, lactation, and/or post-weaning growth on cardiac inflammation, apoptosis, oxidative stress, and nitric oxide system of male and female adult rats. METHODS: Wistar rats were fed a low- or a control zinc diet during pregnancy and up to weaning. Afterward, offspring were fed either a low- or a control zinc diet until 81 days of life...
November 7, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27810284/effects-of-a-novel-positive-psychological-intervention-on-prenatal-stress-and-well-being-a-pilot-randomised-controlled-trial
#20
Karen Matvienko-Sikar, Samantha Dockray
PROBLEM: Low prenatal well-being has adverse outcomes for mother and infant but few interventions currently exist to promote and maintain prenatal well-being. BACKGROUND: Mindfulness and gratitude based interventions consistently demonstrate benefits in diverse populations. Interventions integrating these constructs have potential to improve psychological and physiological health during pregnancy. AIM: The aim of this pilot study is to examine the effect of a novel gratitude and mindfulness based intervention on prenatal stress, cortisol levels, and well-being...
October 31, 2016: Women and Birth: Journal of the Australian College of Midwives
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