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https://www.readbyqxmd.com/read/28546058/the-role-of-il-6-in-neurodevelopment-after-prenatal-stress
#1
Serena B Gumusoglu, Rebecca S Fine, Samuel J Murray, Jada L Bittle, Hanna E Stevens
Prenatal stress exposure is associated with adverse psychiatric outcomes, including autism and ADHD, as well as locomotor and social inhibition and anxiety-like behaviors in animal offspring. Similarly, maternal immune activation also contributes to psychiatric risk and aberrant offspring behavior. The mechanisms underlying these outcomes are not clear. Offspring microglia and the pro-inflammatory cytokine interleukin-6 (IL-6), known to influence microglia, may serve as common mechanisms between prenatal stress and prenatal immune activation...
May 22, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28539405/tumor-susceptibility-gene-101-tsg101-regulates-predisposition-towards-apoptosis-via-escrt-machinery-accessory-proteins
#2
Zenia Kaul, Oishee Chakrabarti
ESCRT proteins are implicated in myriad cellular processes, including endosome formation, fusion of autophagosomes/amphisomes with lysosomes and apoptosis. The role played by these proteins in either facilitating or protecting against apoptosis is still unclear. In this study, while trying to understand how deficiency of Mahogunin RING Finger 1 (MGRN1) affects cell viability, we uncover a novel role for its interactor, the ESCRT-I protein, TSG101 - it directly participates in mitigating ER stress mediated apoptosis...
May 24, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28535425/prenatal-ambient-air-pollution-exposure-infant-growth-and-placental-mitochondrial-dna-content-in-the-inma-birth-cohort
#3
Diana B P Clemente, Maribel Casas, Bram G Janssen, Aitana Lertxundi, Loreto Santa-Marina, Carmen Iñiguez, Sabrina Llop, Jordi Sunyer, Mònica Guxens, Tim S Nawrot, Martine Vrijheid
BACKGROUND: The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate role in this association. OBJECTIVE: In a subset of the Spanish birth cohort INMA we assessed first whether prenatal nitrogen dioxide (NO2) exposure is associated with infant growth. Secondly, we evaluated whether growth at birth (length and weight) could play a mediating role in this association...
May 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28532855/long-term-influence-of-prenatal-high-sucrose-intake-on-learning-and-memory-of-aged-rat-offspring-with-oxidative-stress-and-disruptions-in-nmdars-wnt-signaling-in-hippocampus
#4
Axin He, Yingying Zhang, Lingjun Li, Xueqin Feng, Bin Wei, Di Zhu, Yanping Liu, Lei Wu, Lubo Zhang, Zhice Xu, Miao Sun
Maternal over-nutrition may increase risks of various diseases in the offspring. Our recent work demonstrated that prenatal high sucrose (HS) could impair spatial acquisitionin the adolescentoffspringrats. This study investigated whether prenatal HS has a long-term impact on cognitive capabilities in the aged offspring rats. The aged HS offspring showed impaired glucose tolerance, significantly increased fasting insulin and insulin resistance index, with unchanged plasma glucose. In the navigation test, the aged HS offspring exhibited longer escape latency and longer swimming path length to the platform...
May 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28531807/high-post-natal-mortality-associated-with-defects-in-lung-maturation-and-reduced-adiposity-in-mice-with-gestational-exposure-to-high-fat-and-n-acetylcysteine
#5
Lyda Williams, Maureen J Charron, Rani S Sellers
Studies have demonstrated that maternal consumption of a high fat diet (HFD) increases offspring susceptibility to metabolic disease. This study was initiated to identify the mechanistic contribution of oxidative stress on this phenomenon. Two weeks prior to mating, dams were fed either HFD or Control diet with or without supplementation with the anti-oxidant N-acetylcysteine (NAC). Pups born to HFD dams had reduced crown rump length (CRL) at birth and higher neonatal mortality compared to pups from Control dams...
May 14, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28529816/sclerostin-activity-plays-a-key-role-in-the-negative-effect-of-glucocorticoid-signaling-on-osteoblast-function-in-mice
#6
Eric E Beier, Tzong-Jen Sheu, Emily A Resseguie, Masahiko Takahata, Hani A Awad, Deborah A Cory-Slechta, J Edward Puzas
Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress (PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead (Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling...
2017: Bone Research
https://www.readbyqxmd.com/read/28528960/prenatal-stress-and-epigenetics
#7
REVIEW
L Cao-Lei, S R De Rooij, S King, S G Matthews, G A S Metz, T J Roseboom, M Szyf
In utero exposure to environmental stress in both animals and humans could result in long-term epigenome alterations and which further lead to consequences for adaptation and development in the offspring. Epigenetics, especially DNA methylation, is considered one of the most widely studied and well-characterized mechanisms involved in the long-lasting effects of in utero stress exposure. In this review, we outlined evidence from animal and human prenatal research supporting the view that prenatal stress could lead to lasting, broad and functionally organized signatures in DNA methylation which, in turn, could mediate exposure-phenotype associations...
May 18, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28527042/parenting-stress-among-parents-of-children-with-congenital-diaphragmatic-hernia
#8
Elin Öst, Margret Nisell, Björn Frenckner, Carmen Mesas Burgos, Maria Öjmyr-Joelsson
PURPOSE: The aim of this study was to examine parental stress among parents of children with congenital diaphragmatic hernia (CDH). METHODS: Between 2005 and 2009, a total of 51 children with CDH were treated at Astrid Lindgren Children's Hospital. The survival rate at discharge was 86% and long-term survival rate 80%. One parent each of the long-term survivors (41 children) was included in the present study, and 34 parents (83%) agreed to participate. Participants received the Swedish Parenthood Stress Questionnaire (SPSQ)...
May 19, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28526399/evaluation-of-the-effectiveness-of-chronic-antidepressant-drug-treatments-in-the-hippocampal-mitochondria-a-proteomic-study-in-an-animal-model-of-depression
#9
Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Rafał Olszanecki, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
Several lines of evidence indicate that adverse experience in early life may be a triggering factor for disturbances in the brain mitochondrial proteins and lead to the development of depression in adulthood. On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression. The purpose of our study was to compare the impact of chronic treatment with two antidepressant drugs with different mechanisms of action, a tricyclic antidepressant (TCA), imipramine, and an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, fluoxetine, on the mitochondria-enriched subproteome profile in the hippocampus of 3-month-old male rats following a prenatal stress procedure (an animal model of depression)...
May 16, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28523300/prenatal-glucocorticoid-administration-persistently-increased-the-immunohistochemical-expression-of-type-1-metabotropic-glutamate-receptor-and-purkinje-cell-dendritic-growth-in-the-cerebellar-cortex-of-the-rat
#10
Rodrigo Pascual, Odra Santander, Isabel Cuevas, Martina Valencia
Several studies have indicated that abnormal prenatal changes in the circulating glucocorticoids (GCs), induced by either maternal stress or exogenous GC administration, significantly alter the development of Purkinje cells (PCs). Among the suggested mechanisms that could mediate this GC-dependent PC susceptibility are changes in the expression of type-1 metabotropic glutamate receptors (mGluR1). In the current study, we analyzed whether a single course of prenatally administered betamethasone phosphate (BET) in pregnant rats increased the immunohistochemical expression of mGluR1 in PCs and decreased PC dendritic growth...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28511978/behavioural-outcomes-of-adult-female-offspring-following-maternal-stress-and-perinatal-fluoxetine-exposure
#11
Veronika Kiryanova, Sara J Meunier, Richard H Dyck
Depression, anxiety, and stress are common in pregnant women. One of the primary pharmacological treatments for anxiety and depression is the antidepressant fluoxetine (Flx). Maternal stress, depression, and Flx exposure are known to effect neurodevelopment of the offspring, however, their combined effects have been scarcely studied, especially in female offspring. The present study investigated the combined effects of maternal stress during pregnancy and perinatal exposure to Flx on the behaviour of female mice as adults...
May 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28511454/the-factor-structure-and-psychometric-properties-of-the-persian-version-of-the-revised-prenatal-coping-inventory-nu-pci
#12
Mahbobeh Faramarzi, Hajar Pasha, Sorayya Khafri, Shima Heidary
INTRODUCTION: Familiarity with coping strategies is essential for stress management during pregnancy. The Revised Prenatal Coping Inventory (Nu-PCI) was developed to assess coping strategies during pregnancy. AIM: This study aimed to assess the factor structure and psychometric properties of the Persian version of the Nu-PCI. MATERIALS AND METHODS: After forward-backward translation, the Nu-PCI was administered to 210 pregnant women who were enrolled in two teaching referral clinics in the North of the Islamic Republic of Iran (Babol)...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511050/maternal-distress-in-late-pregnancy-alters-obstetric-outcomes-and-the-expression-of-genes-important-for-placental-glucocorticoid-signalling
#13
Katie L Togher, Eimear Treacy, Gerard W O'Keeffe, Louise C Kenny
The experience of maternal distress in pregnancy is often linked with poorer obstetric outcomes for women as well as adverse outcomes for offspring. Alterations in placental glucocorticoid signalling and subsequent increased fetal exposure to cortisol have been suggested to underlie this relationship. In the current study, 121 pregnant women completed the Perceived Stress Scale, State Trait Anxiety Inventory and Edinburgh Postnatal Depression Scale in the third trimester of pregnancy. Placental samples were collected after delivery...
May 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28507767/post-traumatic-stress-in-pregnant-women-with-primary-cytomegalovirus-infection-and-risk-of-congenital-infection-in-newborns
#14
Francesco Vadini, Elisa Tracanna, Ennio Polilli, Monica Tontodonati, Elena Ricci, Francesca Santilli, Giustino Parruti
BACKGROUND: Substantial evidence indicates that perinatal mental disturbances are associated with the risk for negative maternal-newborn outcomes. A neuroendocrine brain-placenta interaction has been described to explain the association between prenatal stress-related disorders and placental abnormalities. Whether these mechanisms may affect the likelihood of mother-to-child transmission (MTCT) of infections has never been investigated. AIMS: To evaluate the role of psychological factors in cytomegalovirus (CMV) MTCT in pregnant women with primary CMV infection...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/28504975/ce-original-research-the-experiences-of-pregnant-smokers-and-their-providers
#15
Geraldine Rose Britton, Rosemary Collier, Sean McKitrick, Lori Marie Sprague, Joyce Rhodes-Keefe, Ann Feeney, Gary D James
: Background: The U.S. Department of Health and Human Services' initiative Healthy People 2020 targets tobacco use, including smoking during pregnancy, as a continuing major health concern in this country. Yet bringing the U.S. Public Health Service's 2008 clinical practice guideline, Treating Tobacco Use and Dependence, into routine prenatal care remains challenging. Our previous nurse-managed intervention study of rural pregnant women found no significant cessation effect and significant discordance between self-reported smoker status and urinary cotinine levels...
June 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28504008/maternal-resolution-of-preterm-birth-from-1-to-18-months
#16
Maya Yaari, Inbal Millo, Ayelet Harel-Gadassi, Edwa Friedlander, Benjamin Bar-Oz, Smadar Eventov-Friedman, David Mankuta, Nurit Yirmiya
Preterm birth can be traumatic for some mothers, involving feelings of grief over the hoped-for full-term pregnancy. In this longitudinal study, we interviewed 50 mothers of preterm infants, using the reaction to diagnosis interview when their child was 1 month and 18 months old. We examined change and stability in resolution status over time. Additionally, we explored possible predictors of resolution trajectories between 1 and 18 months. Findings indicated that resolution at 1 month was not yet common...
May 15, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28502262/effects-of-combined-iugr-and-prenatal-stress-on-the-development-of-the-hippocampus-in-a-fetal-guinea-pig-model
#17
A L Cumberland, H K Palliser, P Rani, D W Walker, J J Hirst
Intrauterine growth restriction (IUGR) and maternal stress during pregnancy are two compromises that negatively impact neurodevelopment and increase the risk of developing later life neuropsychiatric disorders such as schizophrenia, depression and behavioural disorders. Neurosteroids, particularly allopregnanolone, are important in protecting the developing brain and promoting many essential neurodevelopmental processes. Individually, IUGR and prenatal stress (PS) reduce myelination and neurogenesis within affected fetal brains, however less information is available on the combined effects of these two disorders on the term fetal brain...
May 15, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28499376/benefits-of-preparing-for-childbirth-with-mindfulness-training-a-randomized-controlled-trial-with-active-comparison
#18
Larissa G Duncan, Michael A Cohn, Maria T Chao, Joseph G Cook, Jane Riccobono, Nancy Bardacke
BACKGROUND: Childbirth fear is linked with lower labor pain tolerance and worse postpartum adjustment. Empirically validated childbirth preparation options are lacking for pregnant women facing this problem. Mindfulness approaches, now widely disseminated, can alleviate symptoms of both chronic and acute pain and improve psychological adjustment, suggesting potential benefit when applied to childbirth education. METHODS: This study, the Prenatal Education About Reducing Labor Stress (PEARLS) study, is a randomized controlled trial (RCT; n = 30) of a short, time-intensive, 2...
May 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28494804/validity-of-the-posttraumatic-stress-disorders-ptsd-checklist-in-pregnant-women
#19
Bizu Gelaye, Yinnan Zheng, Maria Elena Medina-Mora, Marta B Rondon, Sixto E Sánchez, Michelle A Williams
BACKGROUND: The PTSD Checklist-civilian (PCL-C) is one of the most commonly used self-report measures of PTSD symptoms, however, little is known about its validity when used in pregnancy. This study aims to evaluate the reliability and validity of the PCL-C as a screen for detecting PTSD symptoms among pregnant women. METHODS: A total of 3372 pregnant women who attended their first prenatal care visit in Lima, Peru participated in the study. We assessed the reliability of the PCL-C items using Cronbach's alpha...
May 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28490175/prenatal-nonylphenol-and-bisphenol-a-exposures-and-inflammation-are-determinants-of-oxidative-nitrative-stress-a-taiwanese-cohort-study
#20
Yu-Fang Huang, Pei-Wei Wang, Li-Wei Huang, Chun-Hao Lai, Winnie Yang, Kuen-Yuh Wu, Chensheng Alex Lu, Hsin-Chang Chen, Mei-Lien Chen
Prenatal exposure to nonylphenol (NP) and/or bisphenol A (BPA) has been reported to be associated with adverse birth outcomes; however, the underlying mechanisms remain unclear. The primary mechanism is endocrine disruption of the binding affinity for the estrogen receptor, but oxidative stress and inflammation might also play a contributory role. We aimed to investigate urinary NP and BPA levels in relation to biomarkers of oxidative/nitrative stress and inflammation and to explore whether changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation in 241 mother-fetus pairs...
May 17, 2017: Environmental Science & Technology
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