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https://www.readbyqxmd.com/read/29356235/contribution-of-intraoperative-radiotherapy-iort-for-therapeutic-de-escalation-in-early-breast-cancer-report-of-a-single-institution-s-experience
#1
Julien Barrou, Agnes Tallet, Monique Cohen, Marie Bannier, Max Buttarelli, Laurence Gonzague, Camille Jauffret, Eric Lambaudie, Sandrine Rua, Margueritte Tyran, Leonel Varela, Gilles Houvenaeghel
The spread of systematic screening and the emergence of oncoplastic techniques allow more breast conservative treatment associating lumpectomy and external beam radiation therapy. In order to furthermore facilitate the patient's treatment, intraoperative radiation therapy (IORT) has been developed. The oncological safety of this technique has been studied, and is considered acceptable. Many questions remain unsolved in regard of the toxicity of this procedure as well as the patient's selection criteria. In this study, we present the first results and complications rate of patients treated by IORT in a single French institution...
January 22, 2018: Breast Journal
https://www.readbyqxmd.com/read/29356021/evaluation-of-fidaxomicin-usage-patterns-and-outcomes-for-clostridium-difficile-infection-across-the-united-states-veterans-health-administration
#2
S E Giancola, R J Williams, C A Gentry
WHAT IS KNOWN AND OBJECTIVE: Fidaxomicin was recently approved for the treatment of Clostridium difficile infection (CDI). Limited data on its use exist outside of the phase 3 trials. The purposes of this study were to assess the compliance with the Veterans Health Administration (VHA) fidaxomicin criteria for use and describe patient characteristics and outcomes following fidaxomicin treatment for CDI using real-world data within the VHA system. METHODS: This was a multicentre, retrospective, observational study including all adult patients who received at least 1 dose of fidaxomicin at any Veterans Affairs Medical Center...
January 21, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29355800/surgical-approaches-for-the-treatment-of-multilevel-cervical-ossification-of-the-posterior-longitudinal-ligament-results-of-a-decision-analysis
#3
Nikhil R Nayak, Matthew Piazza, Andrew Milby, Jayesh P Thawani, Lachlan J Smith, Sherman C Stein, Neil R Malhotra
BACKGROUND: Ossification of the posterior longitudinal ligament (OPLL) often leads to cervical myelopathy. While multiple procedures have been shown to be effective in the treatment of OPLL, outcomes are less predictable than in degenerative cervical myelopathy and surgery is associated with high rates of complications and re-operation which affect quality of life. In this study, we perform a decision analysis utilizing post-operative complication data and health-related quality of life (HRQoL) utility scores to assess the average expected health utility and 5-year quality-adjusted life years (QALYs) associated with the most common surgical approaches for multilevel cervical OPLL...
January 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29355379/fecal-calprotectin-levels-correlate-with-main-domains-of-the-autism-diagnostic-interview-revised-adi-r-in-a-sample-of-individuals-with-autism-spectrum-disorders-from-slovakia
#4
K Babinská, A Tomova, H Celušáková, J Babková, G Repiská, A Kubranská, D Filčíková, L Siklenková, D Ostatníková
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by impaired social interaction and communication, as well as repetitive behavior and restricted interests. There is convincing evidence that the intestinal inflammation is involved in etiology of ASD. Increased levels of inflammatory markers were shown to be associated with more aberrant behaviors and communication of subjects with ASD. Calprotectin in the feces is produced by activated neutrophils and epithelial cells of the gut mucosa, and its levels reflect local inflammation of the gastrointestinal tract...
December 30, 2017: Physiological Research
https://www.readbyqxmd.com/read/29355141/an-observational-study-of-incidence-risk-factors-outcome-of-systemic-inflammatory-response-organ-dysfunction-following-major-trauma
#5
Satish Balkrishna Dharap, Sanket Vishnu Ekhande
BACKGROUND & OBJECTIVES: Trauma is known to lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), which is often a cause of late deaths after injury. SIRS and MODS have been objectively measured using scoring systems. This prospective observational study was carried out in a tertiary care hospital in India to evaluate SIRS and MODS following trauma in terms of their incidence, the associated risk factors and the effect on the outcome. METHODS: All adult patients with major life- and limb-threatening trauma were included...
September 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29354732/c7-intra-laminar-screws-for-complex-cervicothoracic-spine-surgery-a-case-series
#6
Peter John Wilson, Michael Derrick Selby
Background: C7 has relatively unique anatomy compared to the remainder of the subaxial cervical spine (C3-C6) and upper thoracic spine. The C7 laminar has been previously reported in feasibility and biomechanical studies as an adequate fixation point in contrast to the lateral mass or pedicles, with few reports of its use in clinical practice. The purpose of this study was to review the safety and efficacy of using the C7 laminar as a fixation point in constructs involving the cervical spine and cervicothoracic junction...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29354504/multispecialty-retrospective-review-of-the-clinical-utility-of-pelvic-magnetic-resonance-imaging-in-the-setting-of-pelvic-pain
#7
John R Moore, Ram A Pathak, Caroline Snowden, Candice W Bolan, Paul R Young, Gregory A Broderick
Background: Pelvic pain is a common complaint, and management of it is often difficult. We sought to evaluate the utility of magnetic resonance imaging (MRI) in the diagnosis of male pelvic pain. Though MRIs are commonly ordered to evaluate pelvic pain, there are very few studies obtaining the efficacy of pelvic MRI in determining a definitive diagnosis. The primary aim of our study was to evaluate the clinical utility of pelvic MRI for a diagnosis code that included pain. Methods: After receiving institutional review board approval, a retrospective study was performed of all pelvic MRIs completed at our institution from January 2, 2010 to December 31, 2014...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29354432/two-stage-revision-anterior-cruciate-ligament-reconstruction-using-allograft-bone-dowels
#8
Kadir Buyukdogan, Michael S Laidlaw, Mark D Miller
Revision anterior cruciate ligament (ACL) reconstruction is substantially more challenging than primary reconstruction. Management of previously malpositioned or widened tunnels often requires innovative approaches for managing bony defects. Massive osteolysis with poor bone stock and convergence or overlapping of revision tunnels into the previously placed tunnels may necessitate a staged revision procedure. In this surgical technique description, we describe a method for the management of bony deficiencies using allograft bone dowels in staged revision ACL reconstruction...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29354318/promoting-regulatory-reform-the-african-health-profession-regulatory-collaborative-arc-for-nursing-and-midwifery-year-4-evaluation
#9
Maureen A Kelley, Sydney A Spangler, Laura I Tison, Carla M Johnson, Tegan L Callahan, Jill Iliffe, Kenneth W Hepburn, Jessica M Gross
As countries across sub-Saharan Africa work towards universal health coverage and HIV epidemic control, investments seek to bolster the quality and relevance of the health workforce. The African Health Profession Regulatory Collaborative (ARC) partnered with 17 countries across East, Central, and Southern Africa to ensure nurses and midwives were authorized and equipped to provide essential HIV services to pregnant women and children with HIV. Through ARC, nursing leadership teams representing each country identify a priority regulatory function and develop a proposal to strengthen that regulation over a 1-year period...
October 2017: Journal of Nursing Regulation
https://www.readbyqxmd.com/read/29354171/the-challenge-of-nonunion-after-osteosynthesis-of-the-clavicle-is-it-a-biomechanical-or-infection-problem
#10
Giuseppe Rollo, Paolo Pichierri, Antonio Marsilio, Marco Filipponi, Michele Bisaccia, Luigi Meccariello
Introduction: The nonunion rate has been reported between 0.1% and 15%. There are also several predisposing factors for the onset of complications: general factors connected with the patient and specific factors related to the fracture site. The purpose of our study is to review the etiology of nonunion of the clavicle in its atrophic form and investigate the outcomes of the revision treatment in a single step. Materials and methods: Retrospective study on 71 patients suffering from nonunions due to the following treatments: conservative in 13 patients; plate fixation in 12; closed reduction and fixation with K-wire in 24; open reduction and fixation with K-wire...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29353867/factors-controlling-sperm-migration-through-the-oviduct-revealed-by-gene-modified-mouse-models
#11
Yoshitaka Fujihara, Haruhiko Miyata, Masahito Ikawa
Mammalian fertilization is comprised of many steps including sperm survival in the uterus, sperm migration in the female reproductive tract, physiological and morphological changes to the spermatozoa, and sperm-egg interaction in the oviduct. In vitro studies have revealed essential factors for these fertilization steps for over half a century. However, the molecular mechanism of fertilization has recently been revised by the emergence of genetically modified animals. Here, we focus on essential factors for sperm fertilizing ability and describe recent advances in our knowledge of the mechanisms of mammalian fertilization, especially of sperm migration from the uterus into the oviduct...
January 22, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29353775/mechanical-wear-and-oxidative-degradation-analysis-of-retrieved-ultra-high-molecular-weight-polyethylene-acetabular-cups
#12
Dipankar Choudhury, Matúš Ranuša, Robert A Fleming, Martin Vrbka, Ivan Křupka, Matthew G Teeter, Josh Goss, Min Zou
The number of revision joint replacements has been increasing substantially over the last few years. Understanding their failure mechanism is extremely important for improving the design and material selection of current implants. This study includes ten retrieved and four new mildly cross-linked ultra-high molecular weight polyethylene (UHMWPE) acetabular liners. Among them, most of the prostheses (n = 5) were reported to be revised and replaced due to aseptic loosening, followed by painful joint (n = 2), dislocation (n = 1), intra articular ossification (n = 1), combination of wear (liner) and osteolysis (stem) (n=1)...
January 6, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29353488/a-comparative-study-of-the-psychological-problems-of-hiv-infected-and%C3%A2-hiv-uninfected-children-in-a-south-african-sample
#13
M J Visser, H E Hecker, J Jordaan
According to research children living with HIV experience elevated levels of depression, anxiety, ADHD and disruptive behavioural disorders. Although South Africa's paediatric population that is infected with the human immunodeficiency virus (HIV) is the largest worldwide, little research has been conducted on their mental health challenges. However, attributing high levels of mental health problems solely to their HIV status can be problematic as there may be other contributory factors. This research explored the mental health problems of HIV-infected children and compared these to the mental health problems of their HIV-unaffected peers from similar backgrounds...
January 22, 2018: AIDS Care
https://www.readbyqxmd.com/read/29353316/validation-of-a-new-classification-for-periprosthetic-shoulder-fractures
#14
Chlodwig Kirchhoff, Marc Beirer, Ulrich Brunner, Arne Buchholz, Peter Biberthaler, Moritz Crönlein
INTRODUCTION: Successful treatment of periprosthetic shoulder fractures depends on the right strategy, starting with a well-structured classification of the fracture. Unfortunately, clinically relevant factors for treatment planning are missing in the pre-existing classifications. Therefore, the aim of the present study was to describe a new specific classification system for periprosthetic shoulder fractures including a structured treatment algorithm for this important fragility fracture issue...
January 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29352848/association-between-perceived-level-of-stress-clinical-characteristics-and-psychopathological-symptoms-in-women-with-systemic-lupus-erythematosus
#15
María Isabel Peralta-Ramírez, José Manuel Pérez-Mármol, Margarita Castañeda-Cabestany, Ana María Santos-Ruiz, Eva Montero-López, José Luís Callejas-Rubio, Nuria Navarrete-Navarrete, José Carlos Fernández-Sánchez, Juan Francisco Jiménez-Alonso, Norberto Ortego-Centeno, José Mario Sabio, Marta García-Morales
OBJECTIVES: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. METHODS: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352727/re-evaluation-of-target-lipid-model-derived-hc5-predictions-for-hydrocarbons
#16
Joy A McGrath, Christopher J Fanelli, Dominic M Di Toro, Thomas F Parkerton, Aaron D Redman, Miriam Leon Paumen, Mike Comber, Charles V Eadsforth, Klaas den Haan
The Target Lipid Model (TLM) has been previously applied to predict the aquatic toxicity of hydrocarbons and other non-ionic organic chemicals and for deriving HC5 values, concentrations above which 95% of species should be protected. Several concerns were identified with the TLM-derived HC5 when applied in a substance risk assessment context. These shortcomings were addressed by expanding the acute and chronic toxicity databases to include more diverse taxonomic groups and increase the number of species. The TLM was recalibrated with these expanded databases resulting in critical target lipid body burdens and acute-to-chronic ratios that met the required guidelines for using species sensitivity distributions in substance risk assessment...
January 20, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29352690/diagnostic-utility-of-histological-analysis-for-detecting-ongoing-infection-during-two-stage-revision-arthroplasty-in-patients-with-inflammatory-arthritis
#17
Jaiben George, Yaxia Zhang, Michael Jawad, Mhamad Faour, Alison K Klika, Thomas W Bauer, Carlos A Higuera
BACKGROUND: Surgeons often rely on intra-operative histology (frozen sections [FS]) to determine the next step in surgical management during the second stage (re-implantation surgery) of 2-stage revision arthroplasty. The purpose of the study is to assess the accuracy of permanent sections (PS) and FS in the diagnosis of persistent infection during re-implantation in patients with an inflammatory arthritis. METHODS: From 2001 to 2016, 47 planned second-stage revision total hip arthroplasty and total knee arthroplasty in patients with inflammatory arthritis were identified...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352688/the-association-between-readmission-and-patient-experience-in-a-total-hip-arthroplasty-population
#18
(no author information available yet)
BACKGROUND: Our goal was to determine whether readmissions within 30 or 90 days following discharge are associated with Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores for total hip arthroplasty (THA) patients. METHODS: HCAHPS surveys from all patients who underwent THA between January 2016 and September 2016 in our institution were analyzed. Readmissions, demographics, baseline joint pain, joint function, and Veterans RAND-12 scores were collected...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352684/long-term-outcome-of-hip-arthroplasty-in-the-setting-of-pigmented-villonodular-synovitis
#19
Meagan E Tibbo, Cody C Wyles, Peter S Rose, Franklin H Sim, Matthew T Houdek, Michael J Taunton
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare, benign, painful proliferation of the synovium previously treated successfully with total hip arthroplasty (THA). Published results come from small series; therefore, the purpose of this study is to investigate the outcomes of THA in the setting of PVNS. METHODS: We identified 25 patients with histologically confirmed, diffuse PVNS who underwent THA between 1971 and 2013. Mean follow-up and age was 10 years and 39 years...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352592/development-and-validation-of-an-icd-10-based-disability-predictive-index-for-patients-admitted-to-hospitals-with-trauma
#20
Tomoki Wada, Hideo Yasunaga, Hayato Yamana, Hiroki Matsui, Kiyohide Fushimi, Naoto Morimura
BACKGROUND: There was no established disability predictive measurement for patients with trauma that could be used in administrative claims databases. The aim of the present study was to develop and validate a diagnosis-based disability predictive index for severe physical disability at discharge using the International Classification of Diseases, 10th revision (ICD-10) coding. METHODS: This retrospective observational study used the Diagnosis Procedure Combination database in Japan...
December 28, 2017: Injury
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