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atherosclerotic cerebrovascular disease

Angelina M Crans Yoon, Vicki Chiu, Jamal S Rana, Javed Sheikh
BACKGROUND: Inflammation is implicated in atherosclerotic cardiovascular disease. Allergic diseases also involve a systemic inflammatory state, which may potentiate cardiovascular disease. OBJECTIVE: To examine the association of allergic rhinitis, coronary heart disease (CHD), cerebrovascular disease (CVD), and all-cause mortality. METHODS: We conducted a retrospective, population-based, matched cohort study comparing the incidence of CHD, CVD, and all-cause mortality from January 1, 1999, through December 31, 2012, in patients with International Classification of Disease, Ninth Revision, documented allergic rhinitis matched 1:1 by age, sex, and ethnicity to a reference cohort without allergic rhinitis within Kaiser Permanente Southern California...
October 2016: Annals of Allergy, Asthma & Immunology
Rui Machado, Gabriela Teixeira, Pedro Oliveira, Luís Loureiro, Carlos Pereira, Rui Almeida
Introduction: Abdominal aortic aneurysm has a lower incidence in the female population, but a higher complication rate. It was been hypothesized that some anatomical differences of abdominal aortic aneurysm in women could be responsible for that. We proposed to analyze our data to understand the differences in the clinical and anatomical characteristics and the outcomes of patients undergoing endovascular aneurysm repair, according to gender. Methods: A retrospective analysis of patients undergoing endovascular aneurysm repair between 2001-2013 was performed...
May 2016: Brazilian Journal of Cardiovascular Surgery
Aylin Tugcu, Zhezhen Jin, Shunichi Homma, Mitchell S V Elkind, Tatjana Rundek, Mitsuhiro Yoshita, Charles DeCarli, Koki Nakanishi, Sofia Shames, Clinton B Wright, Ralph L Sacco, Marco R Di Tullio
BACKGROUND AND PURPOSE: Aortic arch plaque (AAP) is a risk factor for ischemic stroke, but its association with subclinical cerebrovascular disease is not established. We investigated the association between AAP and subclinical cerebrovascular disease in an elderly stroke-free community-based cohort. METHODS: The CABL study (Cardiovascular Abnormalities and Brain Lesions) was designed to investigate cardiovascular predictors of silent cerebrovascular disease in the elderly...
October 11, 2016: Stroke; a Journal of Cerebral Circulation
Reshmi Srinath, Rebecca F Gottesman, Sherita Hill Golden, Kathryn A Carson, Adrian Dobs
BACKGROUND AND PURPOSE: Epidemiological studies in men suggest a relationship between endogenous testosterone and ischemic vascular events. We hypothesized that low testosterone is independently associated with ischemic stroke and ischemic brain changes. METHODS: In 1558 male participants (mean [SD] age, 63.1 [5.6] years; body mass index, 28.2 [4.3] kg/m(2)) from visit 4 (1996-1998) of the ARIC study (Atherosclerosis Risk in Communities) without cardiovascular disease, stroke, and previous testosterone therapy, we measured plasma total testosterone by liquid chromatography mass spectrometry using morning samples and divided levels into tertiles (median [25th-75th percentile], 377...
October 11, 2016: Stroke; a Journal of Cerebral Circulation
Ana-Catarina Pinho-Gomes, David P Taggart
This review explores the association between left main disease and the increased risk of perioperative stroke following coronary artery bypass grafting, specifically addressing the potential underlying mechanisms and its potential prevention. In particular, this correlation appears stronger for patients with left main disease when compared to patients with isolated triple vessel disease. Even though evidence on this topic is limited and of modest quality, there appears to be a significant association between ascending aorta atherosclerosis and coronary artery disease...
October 3, 2016: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
G Colussi, C Catena, M Novello, N Bertin, L A Sechi
AIMS: To overview the effects of omega-3 polyunsaturated fatty acids (PUFA) on blood vessels and blood pressure (BP) and their relevance for cardiovascular prevention. DATA SYNTHESIS: The importance of omega-3 PUFA for the cardiovascular system has come under the spotlight during the last decades. These fatty acids are present in variable amounts in cell membranes of mammal species, and their content affects a variety of cellular functions. Evidence obtained in animal and human studies suggests that omega-3 PUFA affect many steps of the atherosclerotic process...
July 26, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Karin G Gerritsen, Lucas L Falke, Stefan H van Vuuren, Jan W Leeuwis, Roel Broekhuizen, Tri Q Nguyen, Gert Jan de Borst, Hendrik M Nathoe, Marianne C Verhaar, Robbert J Kok, Roel Goldschmeding, Frank L Visseren
AIMS: Connective tissue growth factor (CTGF) plays a key role in tissue fibrogenesis and growing evidence indicates a pathogenic role in cardiovascular disease. Aim of this study is to investigate the association of connective tissue growth factor (CTGF/CCN2) with cardiovascular risk and mortality in patients with manifest vascular disease. METHODS AND RESULTS: Plasma CTGF was measured by ELISA in a prospective cohort study of 1227 patients with manifest vascular disease (mean age 59...
August 2016: Growth Factors
Iu I Kazakov, I B Lukin, N Iu Sokolova, M A Strakhov
Analysed herein are both immediate and remote results of surgical treatment of 93 patients presenting with chronic atherosclerotic occlusion of the femoral-popliteal-tibial segment in the stage of critical ischaemia. The patients were subjected to autovenous femoropopliteal bypass grafting to the isolated arterial segment or balloon angioplasty with stenting of the superficial femoral artery. While choosing the method of arterial reconstruction we assessed concomitant diseases, primarily lesions of the coronary and cerebral circulation...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Tain-Junn Cheng, Shu-Wen Lin, Chih-Wei Chen, How-Ran Guo, Ying-Jang Wang
Chronic arsenic exposure is associated with cerebrovascular disease and the formation of atherosclerotic lesions. Our previous study demonstrated that arsenic trioxide (ATO) exposure was associated with atherosclerotic lesion formation through alterations in lipid metabolism in the reverse cholesterol transport process. In mouse livers, the expression of the liver X receptor β (LXR-β) and the cholesteryl ester transfer protein (CETP) was suppressed without any changes to the lipid profile. The aim of this study was to elucidate whether ATO contributes to atherosclerotic lesions by suppressing LXR-β and CETP levels in hepatocytes...
October 25, 2016: Chemico-biological Interactions
Marine M Tanashyan, Polina I Kuznetsova, Alla A Shabalina, Anton A Raskurazhev, Olga V Lagoda, Irina N Subortseva, Anait L Melikyan
BACKGROUND: Disturbances of microcirculation play a significant role in the development and progression of both acute and chronic cerebrovascular diseases (CVD) and may be associated with different hemogram abnormalities. One of the reasons of the prothrombogenic state of the endothelium is the increase in the number of blood corpuscles leading to (non-Ph) myeloproliferative disorders (MPD) including essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PM)...
September 7, 2016: Cerebrovascular Diseases Extra
Nicky G F M Beukers, Geert J M G van der Heijden, Arjen J van Wijk, Bruno G Loos
BACKGROUND: The association between periodontitis and atherosclerotic cardiovascular diseases (ACVD) has been established in some modestly sized studies (<10 000). Rarely, however, periodontitis has been studied directly; often tooth loss or self-reported periodontitis has been used as a proxy measure for periodontitis. Our aim is to investigate the adjusted association between periodontitis and ACVD among all individuals registered in a large dental school in the Netherlands (Academic Centre for Dentistry Amsterdam (ACTA))...
August 8, 2016: Journal of Epidemiology and Community Health
J Steinbuch, A C van Dijk, F H B M Schreuder, M T B Truijman, A A J de Rotte, P J Nederkoorn, A van der Lugt, E Hermeling, A P G Hoeks, W H Mess
Purpose: Inhomogeneity of arterial wall thickness may be indicative of distal plaques. This study investigates the intra-subject association between relative spatial intima-media thickness (IMT) inhomogeneity of the common carotid artery (CCA) and the degree of stenosis of plaques in the internal carotid artery (ICA). Materials and Methods: We included 240 patients with a recent ischemic stroke or transient ischemic attack and mild-to-moderate stenosis in the ipsilateral ICA. IMT inhomogeneity was extracted from B-mode ultrasound recordings...
August 3, 2016: Ultraschall in der Medizin
Muharrem Akin, Thomas Skripuletz, L Christian Napp, Dominik Berliner, Ibrahim Akin, Arash Haghikia, Elvan Akin, Johann Bauersachs
Statins are the most widely prescribed drugs to reduce serum low density lipoprotein cholesterol (LDL-C) by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. LDL-C reduction is associated with a decreased risk of atherosclerotic cardiovascular disease (ASCVD), including cardiovascular disease (CVD) and stroke. Statins reduce LDL-C by 30 to 40%, and the combination with other lipid-lowering agents such as ezetimibe leads to a further reduction by 20 to 25%. However, even the combination of these two agents might not be sufficient in high risk patients to require aggressive LDL-C reduction...
July 27, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Oh Young Bang, Jong-Won Chung, Suk Jae Kim, Mi Jeong Oh, Soo Yoon Kim, Yeon Hee Cho, Jihoon Cha, Je Young Yeon, Keon Ha Kim, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee, Chang-Seok Ki, Pyoung Jeon, Jong-Soo Kim, Seung Chyul Hong, Gyeong Joon Moon
BACKGROUND: Moyamoya disease is a unique cerebrovascular occlusive disease of unknown etiology. Ring finger protein 213 (RNF213) was identified as a susceptibility gene for Moyamoya disease in East Asian countries. However, the pathogenesis of Moyamoya disease remains unclear. METHODS: We prospectively analyzed clinical data for 139 patients with Moyamoya disease (108 bilateral Moyamoya disease, 31 unilateral Moyamoya disease), 61 patients with intracranial atherosclerotic stroke, and 68 healthy subjects...
July 26, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Leopoldo Pérez de Isla, Rodrigo Alonso, Nelva Mata, Adriana Saltijeral, Ovidio Muñiz, Patricia Rubio-Marin, José L Diaz-Diaz, Francisco Fuentes, Raimundo de Andrés, Daniel Zambón, Jesús Galiana, Mar Piedecausa, Rocio Aguado, Daniel Mosquera, José I Vidal, Enrique Ruiz, Laura Manjón, Marta Mauri, Teresa Padró, José P Miramontes, Pedro Mata
OBJECTIVE: Heterozygous familial hypercholesterolemia (FH) is the most common premature atherosclerotic cardiovascular disease (ASCVD)-related monogenic disorder, and it is associated with ischemic heart disease. There is limited information whether FH increases the risk of peripheral arterial and cerebrovascular disease. Our aim was to analyze ASCVD prevalence and characteristics in different arterial territories in a large FH population, to compare them with an unaffected control population and to determine which factors are associated to ASCVD...
September 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Luis E Savastano, Arlene Smith, Karla Vega, Carlos Murga-Zamalloa, David Gordon, Micheal Wang, B Gregory Thompson, Eric Seibel, Thomas Wang
INTRODUCTION: Disruption of vulnerable atherosclerotic plaque is the precipitating factor that culminates in thrombosis and ischemia. Current technologies do not have sufficient power to identify subtle thrombogenic lesions (ie, ulcers) in the arterial endoluminal surfaces nor reliably predict markers for future symptomatology. We developed an ultra-thin scanning fiber endoscope (SFE) to directly visualize the endoluminal surface of carotid arteries and identify structural, chemical, and biological markers of vulnerable and complicated atherosclerotic plaques...
August 2016: Neurosurgery
Kinga G Blecharz, Dietmar Frey, Tobias Schenkel, Vincent Prinz, Gloria Bedini, Susanne M Krug, Marcus Czabanka, Josephin Wagner, Michael Fromm, Anna Bersano, Peter Vajkoczy
Moyamoya disease is a rare steno-occlusive cerebrovascular disorder often resulting in hemorrhagic and ischemic strokes. Although sharing the same ischemic stimulus with atherosclerotic cerebrovascular disease, Moyamoya disease is characterized by a highly instable cerebrovascular system which is prone to rupture due to pathological neovascularization. To understand the molecular mechanisms underlying this instability, angiopoietin-2 gene expression was analyzed in middle cerebral artery lesions obtained from Moyamoya disease and atherosclerotic cerebrovascular disease patients...
July 5, 2016: Journal of Cerebral Blood Flow and Metabolism
Yen-Yi Juo, Lisbi Rivas Ramirez, Garry Ruben
BACKGROUND: Atherosclerotic lesions of the supra-aortic trunk vessels, including the innominate artery, subclavian artery, or the common carotid artery, tend to present either as low-flow state distal to the lesion or as embolic events. The risk of embolic cerebrovascular event complicates the management of this condition via a pure endovascular approach. A combined operative-endovascular intervention may be a valuable approach in order to reduce the risk of intraoperative stroke and prevent future embolic events...
August 2016: Vascular and Endovascular Surgery
Karina Gasbarrino, Christos Mantzoros, Jessica Gorgui, John P Veinot, Chi Lai, Stella S Daskalopoulou
OBJECTIVE: The rupture of unstable carotid atherosclerotic plaques is one of the main causes of cerebrovascular ischemic events. There is need for circulating markers that can predict plaque instability and risk of stroke. Proinflammatory chemerin, leptin, and resistin, along with anti-inflammatory adiponectin, are adipokines with direct influence on vascular function. We investigated the association of circulating adipokines with carotid plaque instability and cerebrovascular symptomatology...
August 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Xianjun Han, Linhui Ouyang, Chunning Zhang, Hailing Ma, Jingcui Qin
Deep cerebral veins have been recently associated with the severity of hemodynamic impairment in moyamoya disease. The aim of the current study was to determine the correlation of deep medullary veins (DMVs) in susceptibility-weighted imaging (SWI) with ipsilateral cerebrovascular reactivity (CVR) of and anterior cecebrocervical artery stenosis in patients with ischemic stroke. Patients with unilateral TIA or infarction who underwent 3.0 T magnetic resonance imaging SWI, digital subtraction angiography and transcranial Doppler with CO2 stimulation within the first 7 days of hospitalization were retrospectively selected...
June 2016: Experimental and Therapeutic Medicine
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