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atherosclerotic cerebrovascular disease

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https://www.readbyqxmd.com/read/29739796/prevalence-of-carotid-plaque-in-a-63-to-65-year-old-norwegian-cohort-from-the-general-population-the-ace-akershus-cardiac-examination-1950-study
#1
Håkon Ihle-Hansen, Thea Vigen, Hege Ihle-Hansen, Ole Morten Rønning, Trygve Berge, Bente Thommessen, Magnus Nakrem Lyngbakken, Eivind Bjørkan Orstad, Steve Enger, Ståle Nygård, Helge Røsjø, Arnljot Tveit
BACKGROUND: New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima-media thickness (cIMT) and their relation to cardiovascular risk factors in a middle-aged cohort from the general population...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29703626/temporal-changes-in-statin-prescription-and-intensity-at-discharge-and-impact-on-outcomes-in-patients-with-newly-diagnosed-atherosclerotic-cardiovascular-disease-real-world-experience-within-a-large-integrated-health-care-system-the-impres-study
#2
Jeffrey L Anderson, Kirk U Knowlton, Heidi T May, Tami L Bair, Shannon O Armstrong, Donald L Lappé, Joseph B Muhlestein
BACKGROUND: Statins are indicated for secondary atherosclerotic cardiovascular disease (ASCVD) prevention; however, multiple surveys have found treatment gaps in clinical application. OBJECTIVE: To determine trends over 15 years in the prevalence and impact of a statin prescription and dose intensity at discharge after a first ASCVD event. METHODS: The Intermountain Enterprise Data Warehouse was searched to identify all adults with a first encounter for ASCVD between January 1, 1999 and December 31, 2013, including coronary artery disease, cerebrovascular disease, and peripheral arterial disease, who survived the index event and were followed for ≥3 years or until death...
March 30, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29691467/low-bilirubin-levels-indicate-a-high-risk-of-cerebral-deep-white-matter-lesions-in-apparently-healthy-subjects
#3
Satoshi Higuchi, Yusuke Kabeya, Junko Uchida, Kiyoe Kato, Nobuhiro Tsukada
Recent studies have reported that deep white matter lesions (DWMLs) on magnetic resonance imaging scans are related to the risk of developing impaired cognitive function in future. Bilirubin exhibits a potent antioxidant effect and an inverse relationship has been reported between bilirubin levels and the risk of several atherosclerotic diseases; however, there is limited evidence with regard to the effect of bilirubin levels on cerebrovascular diseases including DWMLs. This cross-sectional study included 1121 apparently healthy Japanese adults...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29619516/hippocampal-calcification-on-brain-ct-prevalence-and-risk-factors-in-a-cerebrovascular-cohort
#4
Remko Kockelkoren, Jill B De Vis, M Stavenga, Willem P Th M Mali, Jeroen Hendrikse, Annemieke M Rozemuller, Huiberdina L Koek, Irene C van der Schaaf, Birgitta K Velthuis, Pim A de Jong
OBJECTIVES: Recently, hippocampal calcification as observed on brain CT examinations was identified in over 20% of people over 50 years of age and a relation between hippocampal calcification and cognitive decline was shown. We determined the prevalence and investigated the vascular risk factors of hippocampal calcification in patients with cerebrovascular disease. METHODS: Hippocampal calcification was scored bilaterally on presence and severity on CT examinations in a cohort of 1130 patients with (suspected) acute ischaemic stroke...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29619063/bushenkangshuai-tablet-reduces-atherosclerotic-lesion-by-improving-blood-lipids-metabolism-and-inhibiting-inflammatory-response-via-tlr4-and-nf-%C3%AE%C2%BA-b-signaling-pathway
#5
Shu-Chao Pang, Li Peng, Jun-Ping Zhang, Yuan-Yuan Wang, Hui-Yun Jia, Li-Yuan Bi, Mei-Ling Chen
Bushenkangshuai tablet (BSKS) is a Chinese herbal compound which has been used for the treatment of cardiovascular and cerebrovascular diseases in China for decades. This study intends to explore the molecular mechanism of BSKS against atherosclerosis in ApoE-/- mice. ApoE-/- mice were fed with western-type diet for 6 weeks and then were given BSKS for 6 weeks. The results showed that BSKS attenuated the size of the atherosclerotic lesion, reduced visceral adipose content, and decreased blood lipids. We also found that BSKS promoted the expression of adiponectin and its receptors, inhibited the expression of Toll-like receptor 4 and nuclear factor-kappa B, decreased the levels of interleukin-1 beta, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1, and increased the levels of interleukin-10 and adiponectin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29600936/association-between-primary-sj%C3%A3-gren-s-syndrome-cardiovascular-and-cerebrovascular-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Wai Chung Yong, Anawin Sanguankeo, Sikarin Upala
OBJECTIVES: Acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation. Studies on cardiovascular or cerebrovascular events in primary Sjögren's syndrome (pSS) are limited, with conflicting results. This meta-analysis aimed to explore the risk of cardiovascular and cerebrovascular disease in pSS. METHODS: A comprehensive search of the MEDLINE and EMBASE databases was performed from date of inception through August 2017...
March 19, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29577540/burden-of-cardio-renal-metabolic-conditions-in-adults-with-type-2-diabetes-within-the-diabetes-collaborative-registry
#7
Suzanne V Arnold, Mikhail Kosiborod, Jingyan Wang, Peter Fenici, Goran Gannedahl, Robert J LoCasale
We examined the prevalence of cardio-renal-metabolic (CaReMe) conditions and their combinations among 530 747 adults with type 2 diabetes in a USA-based outpatient registry of 271 primary care, cardiology and endocrinology offices. We evaluated the following CaReMe conditions: hypertension, hyperlipidaemia, coronary artery disease (CAD), chronic kidney disease (CKD), cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and gout or hyperuricaemia; prevalence estimates were adjusted based on the distribution of diabetes by age in the US population in 2015...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29566551/in-vivo-mri-detection-of-atherosclerosis-in-apoe-deficient-mice-by-using-tenascin-c-targeted-uspio
#8
Yan Li, Jun Liu, Jun-Wen Huang, Jia-Cheng Song, Zhan-Long Ma, Hai-Bin Shi
Background Atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases. Non-invasive molecular imaging to detect and characterize the plaques is essential for reducing life-threatening cardiovascular events. Purpose To investigate the possibility of the anti-tenascin-C-USPIO specific probe as a molecular marker of atherosclerotic plaques detected by 7.0-T magnetic resonance imaging (MRI). Material and Methods Twenty ApoE-/- mice fed with a high fat diet were used for detecting the aorta arch atherosclerotic plaques by 7...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29548814/renin-and-aldosterone-are-not-associated-with-vulnerable-plaque-characteristics-in-patients-with-carotid-artery-disease
#9
Marieke A Hillaert, Hester M den Ruijter, Imo E Hoefer, Eef G Lentjes, Gert J de Borst, Jean-Paul P M de Vries, Pieter A Doevendans, Gerard Pasterkamp, Leo Timmers
BACKGROUND: The renin-angiotensin-aldosterone system is increasingly being recognized to play an important role in the development and clinical course of cardiovascular diseases. Renin-angiotensin-aldosterone system activation is associated with clinical outcome in various populations of cardiovascular patients, such as patients with coronary artery, peripheral artery, and cerebrovascular disease. In this study, we investigated the associations between plasma renin and aldosterone concentrations and atherosclerotic plaque characteristics and secondary vascular events in patients undergoing carotid endarterectomy...
March 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29512455/phytotherapy-for-prevention-of-atherosclerosis-associated-early-cerebral-ischemia
#10
Tatiana V Kirichenko, Veronika A Myasoedova, Igor A Sobenin, Alexander N Orekhov
BACKGROUND: Cerebrovascular disease caused by atherosclerosis affecting cerebral and pre-cerebral arteries is one of the leading causes of morbidity and mortality in high-income countries. Medications of botanical origin are often characterized by good tolerability and are suitable for long-term treatment. Therefore, phytotherapy provides an interesting possibility for developing new therapies for prevention of atherosclerosis and its complications that could be used at preclinical stages of the disease...
March 5, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29502498/perfusion-imaging-and-recurrent-cerebrovascular-events-in-intracranial-atherosclerotic-disease-or-carotid-occlusion
#11
Daniel C Sacchetti, Shawna M Cutting, Ryan A McTaggart, Andrew D Chang, Morgan Hemendinger, Brian Mac Grory, Matthew S Siket, Tina Burton, Bradford Thompson, Sara K Rostanski, Shyam Prabhakaran, Joshua Z Willey, Randolph S Marshall, Mitchell Sv Elkind, Pooja Khatri, Karen L Furie, Mahesh V Jayaraman, Shadi Yaghi
Background Large vessel disease stroke subtype carries the highest risk of early recurrent stroke. In this study we aim to look at the association between impaired perfusion and early stroke recurrence in patients with intracranial atherosclerotic disease or total cervical carotid occlusion. Methods This is a retrospective study from a comprehensive stroke center where we included consecutive patients 18 years or older with intracranial atherosclerotic disease or total cervical carotid occlusion admitted with a diagnosis of ischemic stroke within 24 h from symptom onset with National Institute Health Stroke Scale < 15, between 1 December 2016 and 30 June 2017...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29480889/cardiovascular-and-cerebrovascular-events-are-associated-with-nontraumatic-osteonecrosis-of-the-femoral-head
#12
Pei-Hsun Sung, Yao-Hsu Yang, Hsin-Ju Chiang, John Y Chiang, Chi-Jen Chen, Hon-Kan Yip, Mel S Lee
BACKGROUND: Endothelial dysfunction has been identified as an etiologic factor for osteonecrosis of the femoral head (ONFH) and major adverse cardiovascular and cerebrovascular events (defined as major cardiovascular disease [CVD] and cerebrovascular accident [CVA]). However, the incidence of major adverse cardiovascular and cerebrovascular events in patients with nontraumatic ONFH and any association between the two diagnoses remain unclear. QUESTIONS/PURPOSES: We compared a large cohort of patients with nontraumatic ONFH and a matched control group without this diagnosis and (1) examined the frequency and hazard ratio (HR) of major adverse cardiovascular and cerebrovascular events in both groups adjusted for age, sex, socioeconomic status, and associated comorbidities (which we defined as the adjusted HR), (2) determined whether any association of ONFH and major adverse cardiovascular and cerebrovascular events was stable after adjusting for confounding variables, and (3) compared the occurrence of major adverse cardiovascular and cerebrovascular events with time in both groups...
April 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29449058/-epidemiology-of-lower-extremity-artery-disease
#13
REVIEW
Victor Aboyans, Marie-Antoinette Sevestre, Ileana Désormais, Philippe Lacroix, Gerry Fowkes, Michael H Criqui
It is estimated that more than 200 million individuals are affected by lower extremity artery disease (LEAD) worldwide. This prevalence has increased between 2000 and 2010 by 25%, especially in low/middle income countries. In France, about one million people are affected by this condition. Almost two-thirds of patients with LEAD are asymptomatic. This explains the interest of the measurement of the ankle-brachial index (ABI), an objective and harmless diagnostic tool. An ABI≤0.90 is considered as diagnostic for LEAD...
January 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29448104/aim2-regulates-vascular-smooth-muscle-cell-migration-in-atherosclerosis
#14
Jinyu Pan, Lu Lu, Xuyang Wang, Dian Liu, Jingjing Tian, Hui Liu, Mingjun Zhang, Fengqin Xu, Fengshuang An
BACKGROUND: Atherosclerosis (AS) is a common pathological basis of various cardiovascular and cerebrovascular diseases. Plaque formation is initiated and triggered by vascular smooth musclecells (VSMCs) migration in vascular wall, which gradually aggravates atherosclerosis progression. Absent in melanoma 2 (AIM2), a member of HIN-200 family, plays an important role in activating inflammasome. However, the role of AIM2 in atherosclerotic plaque progression outside of the inflammasome has not yet been reported...
February 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29425278/carotid-intima-media-thickness-and-silent-brain-infarctions-in-a-biracial-cohort-the-atherosclerosis-risk-in-communities-aric-study
#15
Melissa C Caughey, Ye Qiao, B Gwen Windham, Rebecca F Gottesman, Thomas H Mosley, Bruce A Wasserman
Background: Both hypertensive and atherosclerotic processes contribute to common carotid artery intima-media thickness (CCA-IMT). Elevated CCA-IMT may be indicative of subclinical cerebrovascular disease; however, its role in the absence of concomitant carotid artery plaque is uncertain, and few studies have examined associations in black populations. Materials and Methods: At cohort visit 3 (1993-1995) a subset of stroke-free participants (641 blacks and 702 whites, mean age 63) from the Atherosclerosis Risk in Communities (ARIC) study was imaged by brain MRI and carotid ultrasound...
February 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29406924/white-matter-hyperintensities-on-mri-in-dementia-with-lewy-bodies-parkinson-s-disease-with-dementia-and-alzheimer-s-disease
#16
Hideto Joki, Yuichi Higashiyama, Yoshiharu Nakae, Chiharu Kugimoto, Hiroshi Doi, Katsuo Kimura, Hitaru Kishida, Naohisa Ueda, Tatsu Nakano, Tatsuya Takahashi, Shigeru Koyano, Hideyuki Takeuchi, Fumiaki Tanaka
BACKGROUND: In dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), it is still debated whether white matter hyperintensities (WMH) on MRI reflect atherosclerotic cerebrovascular changes or Alzheimer's disease (AD)-related pathology such as cerebral amyloid angiopathy. To examine AD-related pathology in DLB and PDD, we compared the severity of WMH and medial temporal lobe atrophy among patients with DLB, PDD, non-demented PD (PDND), and AD. METHODS: We retrospectively studied sex- and age-matched outpatients with AD, DLB, PDD, and PDND, as well as subjects without central nervous system disorders as normal controls (n=50 each)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29391065/comparison-of-lipid-profiles-and-inflammation-in-pre-and-post-menopausal-women-with-cerebral-infarction-and-the-role-of-atorvastatin-in-such-populations
#17
Jinhong Zhang, Hong Wang, Shuying Yang, Xiufen Wang
BACKGROUND: The risks of atherosclerotic cardiovascular and cerebrovascular diseases in women rapidly increase with age in post-menopausal women. We aimed to investigate the lipid profiles in peri-menopausal women with cerebral infarction and to explore the effects of atorvastatin intervention. METHODS: We collected women aged 40-60 with cerebral infarction between January 2013 and December 2016. Atorvastatin was applied for 6 months in all included patients. Blood lipid profiles, serum pro-inflammation cytokines, intracranial plaque and NIH stroke scale (NIHSS) scores were evaluated before and after atorvastatin treatment...
February 2, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29352760/endothelial-function-estimated-by-digital-reactive-hyperemia-in-patients-with-atherosclerotic-risk-factors-or-coronary-artery-disease
#18
Jeehoon Kang, Hack-Lyoung Kim, Jae-Bin Seo, Jin-Yong Lee, Min-Kyong Moon, Woo-Young Chung
Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digital Reactive Hyperemia Index (RHI) in an actual population with multiple atherosclerotic risk factors or coronary artery disease (CAD). A total of 417 patients from the Seoul National University Boramae Medical Center RHI registry were enrolled in this study...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29352217/bedside-assessment-of-regional-cerebral-perfusion-using-near-infrared-spectroscopy-and-indocyanine-green-in-patients-with-atherosclerotic-occlusive-disease
#19
Hiroshi Saito, Tatsuya Ishikawa, Jun Tanabe, Shinya Kobayashi, Junta Moroi
This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with 15 O-labeled gas...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339691/rationale-design-and-methodology-of-the-evaluation-of-perceptions-knowledge-and-compliance-with-the-guidelines-in-real-life-practice-a-survey-on-the-under-treatment-of-hypercholesterolemia
#20
Volkan Doğan, Özcan Başaran, Bülent Özlek, Oğuzhan Çelik, Eda Özlek, Kadir Uğur Mert, İbrahim Rencüzoğulları, Gurbet Özge Mert, Marwa Mouline Doğan, Murat Biteker, Meral Kayıkçıoğlu
OBJECTIVE: A wide gap exists between dyslipidemia guidelines and their implementation in the real world, which is primarily attributed to physician and patient compliance. The aim of this study is to determine physician and patient adherence to dyslipidemia guidelines and various influential factors. METHODS: The Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia (EPHESUS) trial (ClinicalTrials...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
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