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atherosclerotic cerebrovascular disease

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https://www.readbyqxmd.com/read/29339691/rationale-design-and-methodology-of-the-evaluation-of-perceptions-knowledge-and-compliance-with-the-guidelines-in-real-life-practice-a-survey-on-the-under-treatment-of-hypercholesterolemia
#1
Volkan Doğan, Özcan Başaran, Bülent Özlek, Oğuzhan Çelik, Eda Özlek, Kadir Uğur Mert, İbrahim Rencüzoğulları, Gurbet Özge Mert, Marwa Mouline Doğan, Murat Biteker, Meral Kayıkçıoğlu
OBJECTIVE: A wide gap exists between dyslipidemia guidelines and their implementation in the real world, which is primarily attributed to physician and patient compliance. The aim of this study is to determine physician and patient adherence to dyslipidemia guidelines and various influential factors. METHODS: The Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia (EPHESUS) trial (ClinicalTrials...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29307022/fluorescein-videoangiography-during-extracranial-to-intracranial-bypass-surgery-preliminary-results
#2
Alessandro Narducci, Julia Onken, Marcus Czabanka, Nils Hecht, Peter Vajkoczy
BACKGROUND: Over the last years, intraoperative use of fluorescein is gaining ground in the field of neurosurgery, due to development of a microscope-integrated YELLOW 560 module, with reported experiences in brain malignancies, aneurysms, and arteriovenous malformation surgery. The aim of this study is to determine the feasibility and value of fluorescein videoangiography during bypass procedures. METHODS: The authors enrolled 11 patients who underwent extracranial-to-intracranial bypass for moyamoya disease, atherosclerotic steno-occlusive cerebrovascular disease, and flow replacement during a giant middle cerebral artery (MCA) aneurysm treatment...
January 6, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29305714/diagnoses-of-cardiovascular-disease-or-substance-addiction-abuse-in-us-adults-treated-for-adhd-with-stimulants-or-atomoxetine-is-use-consistent-with-product-labeling
#3
Kathleen A Fairman, Lindsay E Davis, Alyssa M Peckham, David A Sclar
BACKGROUND: Among US adults, utilization of pharmacotherapy for attention-deficit hyperactivity disorder (ADHD) has increased more than ninefold since 1995-1996. Potential contraindications to ADHD pharmacotherapy include serious cardiovascular disease (CVD) and, for stimulants, addictions and bipolar disorder (BPD). OBJECTIVE: To assess the prevalence of potential contraindications among adults treated with ADHD pharmacotherapy. METHODS: A retrospective cohort analysis was performed using the Truven Health MarketScan® database...
January 5, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29230812/the-gut-microbiota-an-emerging-risk-factor-for-cardiovascular-and-cerebrovascular-disease
#4
REVIEW
Stefanie Ascher, Christoph Reinhardt
Commensal gut microbiota have recently been implicated in cardiovascular disease (CVD) and cerebrovascular disease. Atherosclerotic plaque formation depends on the colonization status of the host. In addition to host nutrition and the related microbiota-dependent metabolic changes, activation of innate immune pathways triggers the development of atherosclerosis and supports arterial thrombosis. Gnotobiotic mouse models have uncovered that activation of Toll-like receptor-2 by gut microbial ligands supports von Willebrand factor-integrin mediated platelet deposition to the site of vascular injury...
December 12, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29223732/a-comparison-of-4d-flow-mri-derived-wall-shear-stress-with-computational-fluid-dynamics-methods-for-intracranial-aneurysms-and-carotid-bifurcations-a-review
#5
REVIEW
Jeremy Szajer, Kevin Ho-Shon
BACKGROUND: 4D flow MRI is a relatively quick method for obtaining wall shear stress (WSS) in vivo, a hemodynamic parameter which has shown promise in risk stratification for rupture of cerebrovascular diseases such as intracranial aneurysms and atherosclerotic plaques. The accuracy of such measurements is still largely unknown. OBJECTIVE: To quantify the accuracy of 4D flow MRI-derived wall shear stress values for intracranial aneurysms and carotid bifurcations...
December 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29213140/effects-of-stress-on-the-development-and-progression-of-cardiovascular-disease
#6
REVIEW
Mika Kivimäki, Andrew Steptoe
Cardiovascular disease remains the leading cause of disease burden globally, which underlies the continuing need to identify new complementary targets for prevention. Over the past 5-10 years, the pooling of multiple data sets into 'mega-studies' has accelerated progress in research on stress as a risk and prognostic factor for cardiovascular disease. Severe stressful experiences in childhood, such as physical abuse and household substance abuse, can damage health and increase the risk of multiple chronic conditions in adulthood...
December 7, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29175651/subclinical-cerebrovascular-disease-in-nafld-without-overt-risk-factors-for-atherosclerosis
#7
Lorena Airaghi, Mario Rango, Diletta Maira, Valentina Barbieri, Luca Valenti, Rosa Lombardi, Pietro Biondetti, Silvia Fargion, Anna Ludovica Fracanzani
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease. METHODS: In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. hypertension, diabetes, hypercholesterolemia, obesity). RESULTS: The results suggest that subjects with histologically proven NAFLD have a reduced cerebral perfusion (CBFr) confined to limited brain areas, i...
November 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29129260/lipid-management-in-contemporary-community-practice-results-from-the-provider-assessment-of-lipid-management-palm-registry
#8
MULTICENTER STUDY
Ann Marie Navar, Tracy Y Wang, Shuang Li, Jennifer G Robinson, Anne C Goldberg, Salim Virani, Veronique L Roger, Peter W F Wilson, Joseph Elassal, L Veronica Lee, Eric D Peterson
BACKGROUND: The latest cholesterol guidelines have shifted focus from achieving low-density lipoprotein cholesterol (LDL-C) targets toward statin use and intensity guided by atherosclerotic cardiovascular disease (ASCVD) risk. METHODS: Statin use and intensity were evaluated in 5,905 statin-eligible primary or secondary prevention patients from 138 PALM Registry practices. RESULTS: Overall, 74.7% of eligible adults were on statins; only 42...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29093154/evolution-of-risk-factors-for-atherosclerotic-cardiovascular-events-in-systemic-lupus-erythematosus-a-longterm-prospective-study
#9
Konstantinos Tselios, Dafna D Gladman, Jiandong Su, Olga Ace, Murray B Urowitz
OBJECTIVE: We previously reported the effect of certain factors on cardiovascular disease (CVD) in 250 women with systemic lupus erythematosus (SLE) followed for 8 years. The aim of this study was to delineate their evolution after 15 years of followup. METHODS: There were 210 women with SLE and 138 age-matched healthy women available for analysis after 15 years. Cardiovascular events (CVE) included angina pectoris, myocardial infarction (fatal and nonfatal), transient ischemic attack, and stroke (fatal and nonfatal)...
December 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29089349/thyroid-function-and-the-risk-of-atherosclerotic-cardiovascular-morbidity-and-mortality-the-rotterdam-study
#10
Arjola Bano, Layal Chaker, Francesco U S Mattace-Raso, Aad van der Lugt, M Arfan Ikram, Oscar H Franco, Robin P Peeters, Maryam Kavousi
RATIONALE: Thyroid hormones have been linked with various proatherogenic and antiatherogenic processes. However, the relationship of thyroid function with manifestations of atherosclerosis remains unclear. OBJECTIVE: To investigate the association of thyroid function with atherosclerosis throughout its spectrum; that is, subclinical atherosclerosis, incident atherosclerotic cardiovascular (ASCV) events, and ASCV mortality. METHODS AND RESULTS: This population-based study was embedded within the Rotterdam Study...
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29053903/galectin-3-an-emerging-biomarker-in-stroke-and-cerebrovascular-diseases
#11
Anand Venkatraman, Shalaka Hardas, Nirav Patel, Navkaranbir Singh Bajaj, Garima Arora, Pankaj Arora
BACKGROUND: The carbohydrate-binding molecule Galectin-3 has garnered significant attention recently as a biomarker for various conditions ranging from cardiac disease to obesity. Though there have been several recent studies investigating its role in stroke and other cerebrovascular diseases, awareness of this emerging biomarker in the wider neurology community is limited. METHODS: We performed a systematic search in PubMed, EMBASE, Scopus, CINAHL, Clinicaltrials...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29032752/association-between-apolipoproteins-ai-and-b-and-ultrasound-indicators-of-carotid-atherosclerosis
#12
Zeljko Zivanovic, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic, Svetlana Ruzicka-Kaloci, Djordje Stevan Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic, Petar Slankamenac
BACKGROUND: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology. OBJECTIVE: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29031532/neuroimaging-of-vascular-reserve-in-patients-with-cerebrovascular-diseases
#13
REVIEW
Meher R Juttukonda, Manus J Donahue
Cerebrovascular reactivity, defined broadly as the ability of brain parenchyma to adjust cerebral blood flow in response to altered metabolic demand or a vasoactive stimulus, is being measured with increasing frequency and may have a use for portending new or recurrent stroke risk in patients with cerebrovascular disease. The purpose of this review is to outline (i) the physiological basis of variations in cerebrovascular reactivity, (ii) available approaches for measuring cerebrovascular reactivity in research and clinical settings, and (iii) clinically-relevant cerebrovascular reactivity findings in the context of patients with cerebrovascular disease, including atherosclerotic arterial steno-occlusion, non-atherosclerotic arterial steno-occlusion, anemia, and aging...
October 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/29017805/atherosclerotic-plaque-characteristics-are-not-associated-with-future-cardiovascular-events-in-patients-undergoing-iliofemoral-endarterectomy
#14
Steven T W van Haelst, Saskia Haitjema, Wouter Derksen, Ian van Koeverden, Jean-Paul P M de Vries, Frans L Moll, Hester M den Ruijter, Gerard Pasterkamp, Gert J de Borst
BACKGROUND: Plaque characteristics such as intraplaque hemorrhage (IPH) have been associated with secondary cardiovascular events (CVE) in patients undergoing carotid endarterectomy. In addition, carotid plaques containing macrophage infiltration or a large lipid core size were associated with less restenosis. It is currently unknown whether iliofemoral plaque histopathologic characteristics are predictive for secondary CVE in patients with peripheral arterial disease undergoing iliofemoral endarterectomy...
October 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28993906/antiangiogenesis-and-medical-therapy-failure-in-intracranial-atherosclerosis
#15
Nestor R Gonzalez, Raymond Liou, Florian Kurth, Hao Jiang, Jeffrey Saver
Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide and the one with the worst prognosis. In this study, we assessed the hypothesis that the balance of circulating pro- and antiangiogenic factors plays a role in the evolution of the disease and can be used as a potential marker for the disease course and a target for treatment. Seventy-four patients with severe ICAD were enrolled in this prospective observational study, medically optimized, and followed for 6 months...
October 9, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28984315/pet-imaging-of-the-neurovascular-interface-in-cerebrovascular-disease
#16
REVIEW
Nicholas R Evans, Jason M Tarkin, John R Buscombe, Hugh S Markus, James H F Rudd, Elizabeth A Warburton
Cerebrovascular disease encompasses a range of pathologies that affect different components of the cerebral vasculature and brain parenchyma. Large artery atherosclerosis, acute cerebral ischaemia, and intracerebral small vessel disease all demonstrate altered metabolic processes that are key to their pathogenesis. Although structural imaging techniques such as MRI are the mainstay of clinical care and research in cerebrovascular disease, they have limited ability to detect these pathophysiological processes in vivo...
November 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28983441/high-value-care-in-the-evaluation-of-stroke
#17
Prakrity Urja, Eric H Nippoldt, Virginia Barak, Carrie Valenta
Value-based care emphasizes achieving the greatest overall health benefit for every dollar spent. We present an interesting case of stroke, which made us consider how frequently health care providers are utilizing value-based care. A 73-year-old Caucasian, who was initially admitted for a hypertensive emergency, was transferred to our facility for worsening slurring of speech and left-sided weakness. The patient had an extensive chronic cerebrovascular disease, including multiple embolic type strokes, mainly in the distribution of the right temporal-occipital cerebral artery and transient ischemic attacks (TIAs)...
August 1, 2017: Curēus
https://www.readbyqxmd.com/read/28977886/combined-renin-angiotensin-aldosterone-system-blockade-and-statin-therapy-effectively-reduces-the-risk-of-cerebrovascular-accident-in-autosomal-dominant-polycystic-kidney-disease-a-nationwide-population-based-cohort-study
#18
Pei-Hsun Sung, Hsin-Ju Chiang, Mel S Lee, John Y Chiang, Hon-Kan Yip, Yao-Hsu Yang
Fairly limited data reported the incidence and risk of cerebrovascular accident (CVA) in autosomal dominant polycystic kidney disease (ADPKD). Additionally, little is known regarding the therapeutic impact of renin-angiotensin-aldosterone system (RAAS) blockade and statin on reducing the occurrence of CVA in ADPKD. We utilized the data from Taiwan National Health Insurance Research Database (NHIRD) to perform a population-based cohort study (1997-2013). A total of 2,647 patients with ADPKD were selected from 1,000,000 general population after excluding patients with age<18, renal replacement therapy and concomitant diagnosis of CVA...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28942481/high-resolution-vessel-wall-mri-for-the-evaluation-of-intracranial-atherosclerotic-disease
#19
REVIEW
Adam de Havenon, Mahmud Mossa-Basha, Lubdha Shah, Seong-Eun Kim, Min Park, Dennis Parker, J Scott McNally
High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology...
December 2017: Neuroradiology
https://www.readbyqxmd.com/read/28919704/secondary-prevention-of-major-cerebrovascular-events-with-seven-different-statins-a-multi-treatment-meta-analysis
#20
Ping Zhong, Danhong Wu, Xiaofei Ye, Ying Wu, Tuming Li, Shuwen Tong, Xueyuan Liu
BACKGROUND: Statins have been recommended for the use in atherosclerotic cardiovascular diseases, but different statins have distinct pharmacological characteristics. This multi-treatment meta-analysis aimed to evaluate the efficacy of seven statins in the secondary prevention of major cerebrovascular events (CVEs). METHODS AND ANALYSES: The PubMed, Embase, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials were searched to identify studies published between January 1, 2011, and June 30, 2016...
2017: Drug Design, Development and Therapy
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