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https://www.readbyqxmd.com/read/27749810/importance-of-urine-dipstick-in-evaluation-of-young-febrile-infants-with-positive-urine-culture-a-spanish-pediatric-emergency-research-group-study
#1
Roberto Velasco, Helvia Benito, Rebeca Mozun, Juan E Trujillo, Pedro A Merino, Mercedes de la Torre, Borja Gomez, Santiago Mintegi
BACKGROUND AND OBJECTIVES: Guidelines from the American Academy of Pediatrics define urinary tract infection (UTI) as the growth of greater than 50,000 ufc/mL of a single bacterium in a urine culture with a positive urine dipstick or with a urinalysis associated. Our objective was to evaluate the adequacy of this cutoff point for the diagnosis of UTI in young febrile infants. METHODS: Subanalysis of a prospective multicenter study developed in RISeuP-SPERG Network between October 11 and September 13...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27714578/jennifer-w-shewmaker-sexualized-media-messages-and-our-children-teaching-kids-to-be-smart-critics-and-consumers-praeger-santa-barbara-ca-2015-182-pp-isbn-978-1-4408-3333-5
#2
https://www.readbyqxmd.com/read/27597413/development-of-highly-potent-phosphodiesterase-4-inhibitors-with-anti-neuroinflammation-potential-design-synthesis-and-structure-activity-relationship-study-of-catecholamides-bearing-aromatic-rings
#3
Zhong-Zhen Zhou, Bing-Chen Ge, Qiu-Ping Zhong, Chang Huang, Yu-Fang Cheng, Xue-Mei Yang, Hai-Tao Wang, Jiang-Ping Xu
In this study, catecholamides (7a-l) bearing different aromatic rings (such as pyridine-2-yl, pyridine-3-yl, phenyl, and 2-chlorophenyl groups) were synthesized as potent phosphodiesterase (PDE) 4 inhibitors. The inhibitory activities of these compounds were evaluated against the core catalytic domains of human PDE4 (PDE4CAT), full-length PDE4A4, PDE4B1, PDE4C1, and PDE4D7 enzymes, and other PDE family members. Eight of the synthesized compounds were identified as having submicromolar IC50 values in the mid-to low-nanomolar range...
August 24, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27525874/development-of-novel-polymorphic-microsatellite-markers-in-siganus-fuscescens
#4
X Q Mao, Z B Li, Y F Ning, J B Shangguan, Y Yuan, Y S Huang, B B Li
Rabbitfish, Siganus fuscescens, is widely distributed in the Indo-Pacific regions and eastern Mediterranean. Its dwelling place includes reef flats, coral reef regions, and seagrass meadows in tropical area and reef areas or shallow waters in locations at high latitudes. In the present study, 10 new polymorphic microsatellite markers were screened from 30 wild S. fuscescens individuals, using a method of fast isolation protocol and amplified fragment length polymorphism of sequences containing repeats. The number of polymorphic alleles per locus was 3 to 5 with a mean of 4...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27431795/conjugation-of-biogenic-and-synthetic-polyamines-with-serum-proteins-a-comprehensive-review
#5
P Chanphai, T J Thomas, H A Tajmir-Riahi
We have reviewed the conjugation of biogenic polyamines spermine (spm), spermidine (spmd) and synthetic polyamines 3,7,11,15-tetrazaheptadecane.4HCl (BE-333) and 3,7,11,15,19-pentazahenicosane.5HCl (BE-3333) with human serum albumin (HSA), bovine serum albumin (BSA) and milk beta-lactoglobulin (b-LG) in aqueous solution at physiological pH. The results of multiple spectroscopic methods and molecular modeling were analysed here and correlations between polyamine binding mode and protein structural changes were estabilished...
July 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27393444/short-communication-evaluation-of-antimicrobial-activities-of-harmine-harmaline-nicotine-and-their-complexes
#6
Saad Salman, Fariha Idrees, Sadia Pervaiz, Fahad Hassan Shah, Sareer Badshah, Abdullah, Mohammad Usman, Sm Ashhad Halimi, Jawaria Idrees
Harmine, Harmaline, Nicotine and its various complexes synthesized have been characterized by physical, spectral and analytical methods and curtained for in-vitro antimicrobial activity against different bacterial and fungal species at two different concentrations i.e.100μ/100µl and 200μ/100µl dose level respectively. Analysis showed that Nicotine, Zinc-Nico, Cd-Nico, Hg-Nico, Ni-Nico, Cu-Nico, Co-Nico, Harmine, and Harmaline having conc. of 100ug/ 100ul had antibacterial activity on zero, 5, 4, 10, zero, 5, 7, zero, zero strain of bacteria having an average of zero (SD=0...
July 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27258281/guided-mode-leaky-mode-guided-mode-fiber-interferometer-and-its-high-sensitivity-refractive-index-sensing-technology
#7
Qi Wang, Chunyue Li, Chengwu Zhao, Weizheng Li
A cascaded symmetrical dual-taper Mach-Zehnder interferometer structure based on guided-mode and leaky-mode interference is proposed in this paper. Firstly, the interference spectrum characteristics of interferometer has been analyzed by the Finite Difference-Beam Propagation Method (FD-BPM). When the diameter of taper waist is 20 μm-30 μm, dual-taper length is 1 mm and taper distance is 4 cm-6 cm, the spectral contrast is higher, which is suitable for sensing. Secondly, experimental research on refractive index sensitivity is carried out...
2016: Sensors
https://www.readbyqxmd.com/read/27198844/achieving-maternal-and-child-health-gains-in-afghanistan-a-countdown-to-2015-country-case-study
#8
Nadia Akseer, Ahmad S Salehi, S M Moazzem Hossain, M Taufiq Mashal, M Hafiz Rasooly, Zaid Bhatti, Arjumand Rizvi, Zulfiqar A Bhutta
BACKGROUND: After the fall of the Taliban in 2001, Afghanistan experienced a tumultuous period of democracy overshadowed by conflict, widespread insurgency, and an inflow of development assistance. Although there have been several cross-sectional assessments of health gains over the last decade, there has been no systematic analysis of progress and factors influencing maternal and child health in Afghanistan. METHODS: We undertook a comprehensive, systematic assessment of reproductive, maternal, newborn, and child health in Afghanistan over the last decade...
June 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27189918/characterization-of-the-gene-encoding-a-fibrinogen-related-protein-expressed-in-crassostrea-gigas-hemocytes
#9
M A Skazina, A M Gorbushin
Four exons of the CgFrep1 gene (3333 bp long) encode a putative fibrinogen-related protein (324 aa) bearing a single C-terminal FBG domain. Transcripts of the gene obtained from hemocytes of different Pacific oysters show prominent individual variation based on SNP and indels of tandem repeats resulted in polymorphism of N-terminus of the putative CgFrep1 polypeptide. The polypeptide chain bears N-terminal coiled-coil region potentially acting as inter-subunit interface in the protein oligomerization. It is suggested that CgFrep1 gene encodes the oligomeric lectin composed of at least two subunits...
July 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27122113/field-effect-transistors-ultrathin-mxene-micropattern-based-field-effect-transistor-for-probing-neural-activity-adv-mater-17-2016
#10
Bingzhe Xu, Minshen Zhu, Wencong Zhang, Xu Zhen, Zengxia Pei, Qi Xue, Chunyi Zhi, Peng Shi
A field-effect transistor (FET) based on ultrathin Ti3 C2 -MXene micropatterns is developed by C. Zhi, P. Shi, and co-workers, as described on page 3333. The FET can be utilized for label-free probing of small molecules in typical biological environments, e.g., for fast detection of action potentials in primary neurons. This device is produced with a microcontact printing technique, harnessing the unique advantages for easy fabrication.
May 2016: Advanced Materials
https://www.readbyqxmd.com/read/27095920/the-role-of-vipalbumin-%C3%A2-as-an-immunostimulatory-agent-for-controlling-homeostasis-and-proliferation-of-lymphoid-cells
#11
Dinia Rizqi Dwijayanti, Muhammad Sasmito Djati, Muhaimin Rifa'I
VipAlbumin(®) is a supplement from snakehead fish (Ophiocephalus striatus) which has high content of albumin that is very important to develop new cells. The aims of this study were to know the effect of VipAlbumin(®) to cell proliferation, expression level of CD4(+)CD62L(+) T cell, regulatory T cell, and B220+ cell, and immunocompetent cell cycle. Cell isolated from spleen of pathogen free mice were cultured in RPMI 1640 with 10% FBS, 1% Pen/Strep 10×, 2-Mercaptoetanol, anti-CD3 and LPS. The concentrations of VipAlbumin (®) used were 0 µg/ml; 0...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/26986538/the-neo-bioscore-update-for-staging-breast-cancer-treated-with-neoadjuvant-chemotherapy-incorporation-of-prognostic-biologic-factors-into-staging-after-treatment
#12
Elizabeth A Mittendorf, Jose Vila, Susan L Tucker, Mariana Chavez-MacGregor, Benjamin D Smith, W Fraser Symmans, Aysegul A Sahin, Gabriel N Hortobagyi, Kelly K Hunt
IMPORTANCE: We previously described and validated a breast cancer staging system (CPS+EG, clinical-pathologic scoring system incorporating estrogen receptor-negative disease and nuclear grade 3 tumor pathology) for assessing prognosis after neoadjuvant chemotherapy using pretreatment clinical stage, posttreatment pathologic stage, estrogen receptor (ER) status, and grade. Development of the CPS+EG staging system predated routine administration of trastuzumab in patients with ERBB2-positive disease (formerly HER2 or HER2/neu)...
July 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/26892122/assessment-of-statin-therapy-ldl-c-levels-and-cardiovascular-events-among-high-risk-patients-in-the-united-states
#13
Sudhir K Unni, Ruben G W Quek, Joseph Biskupiak, Vinson C Lee, Xiangyang Ye, Shravanthi R Gandra
BACKGROUND: Statins have demonstrated significant benefit in reducing cardiovascular disease (CVD) risk. OBJECTIVE: To evaluate statin treatment patterns by intensity, elevated low-density lipoprotein cholesterol (LDL-C) levels, and cardiovascular (CV) events in high-risk CVD patients. METHODS: Patients included were aged ≥ 18 years, with a coronary heart disease (CHD; Jan 1, 2007-Dec 31, 2011, index date) or CHD risk equivalent (CHD RE) diagnosis (Jan 1, 2007-Dec 31, 2010, index date), in the Truven MarketScan claims database, continuously enrolled for 2 years pre- and up to 1 (CHD) or 2 (CHD RE) years post-index...
January 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26889732/effect-of-normal-walking-pattern-based-functional-electrical-stimulation-on-gait-of-the-lower-extremity-in-subjects-with-ischemic-stroke-a-self-controlled-study
#14
Benlei Xu, Tiebin Yan, Yuanle Yang, Ruiqing Ou, Shuping Huang
BACKGROUND: Functional electrical stimulation is a widely used technique for rehabilitation. OBJECTIVE: To assess the efficacy of walking-pattern-based four-channel functional electric stimulation and its influence on the gait features of stroke patients with hemiplegia. METHODS: A total of 21 stroke patients with hemiplegia were enrolled into the study. The walking gaits of patients were investigated before, during and after walking-pattern-based FES treatment using the gait analysis system...
2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/26860700/non-alcoholic-fatty-liver-disease-nafld-is-associated-with-impairment-of-health-related-quality-of-life-hrqol
#15
COMPARATIVE STUDY
Pegah Golabi, Munkhzul Otgonsuren, Rebecca Cable, Sean Felix, Aaron Koenig, Mehmet Sayiner, Zobair M Younossi
BACKGROUND: NAFLD impacts patient reported outcomes (PROs). Our aim was to assess the impact of NAFLD on patients' HRQOL. METHODS: National Health and Nutrition Examination Survey (NHANES) 2001-2011 data were used to identify adult patients with NAFLD [Fatty Liver Index (FLI) > 60 in absence of other liver disease and excessive alcohol >20 g/day for men, >10 g/day for women]. Patients with other chronic diseases (ex. HIV, cancer, end-stage kidney disease) were excluded...
2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/26726539/photo-thermally-induced-current-switching-in-vanadium-dioxide-based-devices-using-co2-laser-pumping
#16
Jihoon Kim, Songhyun Jo, Kyongsoo Park, Bong-Jun Kim, Yong Wook Lee
By utilizing a CO2 laser as an illumination light source for triggering, we demonstrated bidirectional laser triggering in a two-terminal planar device based on a highly resistive vanadium dioxide (VO2) thin film. Bidirectional laser triggering between 0 and 10 mA was realized by switching the CO2 laser whose focused beam illuminated the VO2 film, and transient responses of laser-triggered devices were investigated when periodical laser pulses excited the VO2-based device at a variety of pulse widths and repetition rates...
November 2015: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/26475443/jennifer-w-shewmaker-sexualized-media-messages-and-our-children-teaching-kids-to-be-smart-critics-and-consumers-praeger-santa-barbara-ca-2015-182-pp-isbn-978-1-4408-3333-5
#17
https://www.readbyqxmd.com/read/26313070/major-surgery-in-south-india-a-retrospective-audit-of-hospital-claim-data-from-a-large-community-health-insurance-programme
#18
Maaz Shaikh, Mark Woodward, Kazem Rahimi, Anushka Patel, Santosh Rath, Stephen MacMahon, Vivekanand Jha
BACKGROUND: Information about use of major surgery in India is scarce. This study aims to bridge this gap by auditing hospital claims from the Rajiv Aarogyasri Community Health Insurance Scheme (RACHIS) that provides access to free tertiary care for major surgery through state-funded insurance to 68 million beneficiaries with limited household incomes-81% of population in states of Telangana and Andhra Pradesh (combined Human Development Index 0·485). Beneficiary households receive an annual coverage of INR 200 000 (US$3333) for admissions to any empanelled public or private hospital...
April 27, 2015: Lancet
https://www.readbyqxmd.com/read/26292051/a-computational-study-of-the-effect-of-the-metal-organic-framework-environment-on-the-release-of-chemically-stored-nitric-oxide
#19
Tanping Li, Kiara Taylor-Edinbyrd, Revati Kumar
The use of copper based metal organic frameworks as a vehicle for the storage and delivery of chemically stored nitric oxide has been proposed based on recent experiments [J. Am. Chem. Soc., 2012, 134, 3330-3333]. In these experiments copper based metal organic frameworks (MOFs) suspended in ethanol catalytically convert chemically stored nitric oxide (in the S-nitrosothiol or RSNO form) to free nitric oxide at a slow and sustained rate, as compared to a quick release in a solution of ethanol containing free copper ions...
September 28, 2015: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/26199290/supply-and-demand-will-we-have-enough-vascular-surgeons-by-2030
#20
Katherine Williams, Brandon Schneider, Paul Lajos, Michael Marin, Peter Faries
The increase in prevalence of certain cardiovascular risk factors increases susceptibility to vascular disease, which may create demand for surgical intervention. In our study, data collected by the American Association of Medical Colleges Physician Specialty Databook of 2012, the United States Census Bureau, and other nationwide organizations were referenced to calculate future changes in vascular surgeon supply and prevalence of people at risk for vascular disease. In 2010, there were 2853 active vascular surgeons...
August 2016: Vascular
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