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https://www.readbyqxmd.com/read/29462353/predicition-models-for-delayed-graft-function-external-validation-on-the-dutch-prospective-renal-transplantation-registry
#1
Jesper Kers, Hessel Peters-Sengers, Martin B A Heemskerk, Stefan P Berger, Michiel G H Betjes, Arjan D van Zuilen, Luuk B Hilbrands, Johan W de Fijter, Azam S Nurmohamed, Maarten H Christiaans, Jaap J Homan van der Heide, Thomas P A Debray, Fréderike J Bemelman
Background: Delayed graft function (DGF) is a common complication after kidney transplantation in the era of accepting an equal number of brain- and circulatory-death donor kidneys in the Netherlands. To identify those cases with an increased risk of developing DGF, various multivariable algorithms have been proposed. The objective was to validate the reproducibility of four predictive algorithms by Irish et al. (A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation...
February 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29451309/antibodies-to-human-neutrophil-antigen-hna-3b-implicated-in-cases-of-neonatal-alloimmune-neutropenia
#2
Larissa Barbosa Lopes, Samira Ali Abbas, Elyse Moritz, Juliana Oliveira Martins, Akemi Kuroda Chiba, Dante Mário Langhi, José O Bordin
BACKGROUND: Neonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a; however, to date, antibodies specific to HNA-3b have not been reported. STUDY DESIGN AND METHODS: Blood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29447927/impact-of-exposure-factor-selection-on-deterministic-consumer-exposure-assessment
#3
Hyunkyung Ban, Ji Young Park, Daeyeop Lee, Kiyoung Lee
Deterministic exposure assessment has uncertainty about the selection of input parameters on the resulting estimates. The purpose of this study was to compare inhalation exposures estimated by a specific percentile of each of the three exposure factors in deterministic assessment with population exposure. Exposure to nine household care products, namely a deodorizer, six cleaning products, and two disinfectants were investigated. The population exposures were individually calculated for three exposure factors (frequency of use, amount of use, and duration of use) from an existing database of 3333 participants representing the national population...
February 12, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29384742/comparisons-between-skeletal-and-dental-age-assessment-in-unaccompanied-asylum-seeking-children
#4
COMPARATIVE STUDY
S I Kvaal, M Haugen
BACKGROUND: For children with disputed date of birth, age assessments based on skeletal and dental development are recommended. AIM: The aim of this retrospective study was to compare and contrast the results of age assessments from these two methods performed on unaccompanied asylum seeking children in Norway. In addition the aim of the analysis was to see if the skeletal age assessment from hand-wrist was operator sensitive. MATERIALS AND METHODS: Age assessments performed from January 2010 to December 2014 were analysed...
December 1, 2017: Journal of Forensic Odonto-stomatology
https://www.readbyqxmd.com/read/29356655/difficulty-buying-food-bmi-and-eating-habits-in-young-children
#5
Anne Fuller, Jonathon L Maguire, Sarah Carsley, Yang Chen, Gerald Lebovic, Jessica Omand, Patricia Parkin, Catherine S Birken
OBJECTIVES: To determine whether parent report of difficulty buying food was associated with child body mass index (BMI) z-score or with eating habits in young children. METHODS: This was a cross-sectional study in primary care offices in Toronto, Ontario. Subjects were children aged 1-5 years and their caregivers, recruited through the TARGet Kids! Research Network from July 2008 to August 2011. Regression models were developed to test the association between parent report of difficulty buying food because of cost and the following outcomes: child BMI z-score, parent's report of child's intake of fruit and vegetables, fruit juice and sweetened beverages, and fast food...
January 22, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29237995/recovery-of-bordetella-bronchiseptica-sequence-type-82-and-b-pseudohinzii-from-urban-rats-in-terengganu-malaysia
#6
Shih Keng Loong, Nurul-Asma-Anati Che-Mat-Seri, Osama Abdulrazak, Benacer Douadi, Siti-Noraisah Ahmad-Nasrah, Jefree Johari, Siti-Nursheena Mohd-Zain, Sazaly Abubakar
Rodents have historically been associated with zoonotic pandemics that claimed the lives of large human populations. Appropriate pathogen surveillance initiatives could contribute to early detection of zoonotic infections to prevent future outbreaks. Bordetella species are bacteria known to cause mild to severe respiratory disease in mammals and, some have been described to infect, colonize and spread in rodents. There is a lack of information on the population diversity of bordetellae among Malaysian wild rodents...
January 27, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29057724/incidence-and-survival-of-oropharyngeal-cancer-in-denmark-a-nation-wide-population-based-study-from-1980-to-2014
#7
Jakob Schmidt Jensen, David Hebbelstrup Jensen, Christian Grønhøj, Kirstine Kim Schmidt Karnov, Cecilie Nørregaard, Tina Klitmøller Agander, Lena Specht, Christian von Buchwald
BACKGROUND: Oropharyngeal carcinomas (OPCs) constitute a significant and increasing proportion of head and neck carcinomas and are an important global cause of morbidity and mortality. The purpose of this study was to determine trends in incidence and survival in OPC in the Danish population from 1980 to 2014. METHODS: This study included all patients registered in the nationwide Danish Cancer Registry over the period 1980-2014. The age-adjusted incidence rates (AAIR) per 100,000, annual percentage change (APC) and average annual percent change (AAPC) were evaluated...
October 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28973491/genetic-structure-of-the-aphis-craccivora-hemiptera-aphididae-from-thailand-inferred-from-mitochondrial-coi-gene-sequence
#8
Kanyanat Wongsa, Orawan Duangphakdee, Atsalek Rattanawannee
The cowpea aphid, Aphis craccivora Koch (Hemiptera: Aphididae), is one of the most destructive insect pests of legume plants worldwide. Although outbreaks of this pest occur annually in Thailand causing heavy damage, its genetic structure and demographic history are poorly understood. In order to determine genetic structure and genetic relationship of the geographic populations of this species, we examined sequences of mitochondrial cytochrome c oxidase subunit I (COI) gene of 51 individuals collected from 32 localities throughout Thailand...
July 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28932473/bis-%C3%AE-n-n-di-allyl-dithio-carbamato-bis-n-n-di-allyl-dithio-carbamato-cadmium
#9
Damian C Onwudiwe, Madalina Hrubaru, Eric C Hosten, Charmaine Arderne
The title compound, [Cd2(C7H10NS2)4], is a neutral dinuclear cadmium(II) complex bearing four bis N,N-di-allyl-di-thio-carbamate ligands coordinating to two Cd(II) cations. In each of the monomeric subunits, there are four S atoms of two di-thio-carbamate ligands [Cd-S = 2.5558 (3), 2.8016 (3), 2.6050 (3) and 2.5709 (3) Å] that coordinate to one Cd(II) atom in a bidentate mode. The dimers are located over an inversion centre bridged by two additional bridging Cd-S bonds [2.6021 (3) Å], leading to a substantial distortion of the geometry of the monomeric subunit from the expected square-planar geometry...
September 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28890977/correction-enzyme-responsive-reporter-molecules-for-selective-localization-and-fluorescence-imaging-of-pathogenic-biofilms
#10
Junxin Aw, Frances Widjaja, Yichen Ding, Jing Mu, Liang Yang, Bengang Xing
Correction for 'Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms' by Junxin Aw et al., Chem. Commun., 2017, 53, 3330-3333.
September 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28752389/a-comparative-analysis-of-child-passenger-restraint-use-in-china-and-the-united-states
#11
Jing-Zhen Yang, Li-Ping Li, Hong-Qian Wu, Daniel McGehee, Corinne Peek-Asa
BACKGROUND: Few published studies have examined child passenger safety practices across countries. This study compared the prevalence and associated factors of child passenger restraint use among children, aged 0 to 17 in the state of Iowa in the United States, and the city of Shantou in China. METHODS: Child restraint use observations were conducted in Iowa and in Shantou in 2012, respectively, among child passengers. Observations in Iowa were conducted at randomly selected gas stations, while in Shantou observations were completed at randomly selected schools or medical clinics...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28494302/super-high-removal-capacities-of-heavy-metals-pb-2-and-cu-2-using-cnt-dendrimer
#12
Bagher Hayati, Afshin Maleki, Farhood Najafi, Hiua Daraei, Fardin Gharibi, Gordon McKay
This research demonstrates the capability of carbon nanotubes (CNT) modified with four generations of poly-amidoamine dendrimer (PAMAM, G4) to remove Cu2+ and Pb2+ heavy metals from aqueous solution in single and binary component systems. Uniquely high adsorption capacities for copper and lead, which are 3333 and 4870mg/g respectively, were achieved. FTIR, H1 NMR, Zeta potential, SEM and TEM techniques were employed for characterizing the synthetic nanocomposite and indicated that the dendrimer functionalized CNTs have been synthesized...
August 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28440386/effect-of-chemical-structure-of-s-nitrosothiols-on-nitric-oxide-release-mediated-by-the-copper-sites-of-a-metal-organic-framework-based-environment
#13
Kiara Taylor-Edinbyrd, Tanping Li, Revati Kumar
The effect of chemical structure of different biologically compatible S-nitrosothiols on the solvation environment at catalytic copper sites in a metal organic framework (MOF) suspended in a solution of ethanol is probed using computational methods. The use of a copper based MOF as a storage vehicle and catalyst (copper sites of the MOF) in the controlled and sustained release of chemically stored nitric oxide (NO) from S-nitrosocysteine has been shown to occur both experimentally and computationally [J. Am...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28257881/dual-mechanism-gastroretentive-drug-delivery-system-loaded-with-an-amorphous-solid-dispersion-prepared-by-hot-melt-extrusion
#14
Anh Q Vo, Xin Feng, Manjeet Pimparade, Xinyou Ye, Dong Wuk Kim, Scott T Martin, Michael A Repka
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation. The bioadhesive floating pellets, loaded with an amorphous solid dispersion, were prepared in a single step of hot-melt extrusion technology. Hydroxypropyl cellulose (Klucel™ MF) and hypromellose (Benecel™ K15M) were used as matrix-forming polymers, and felodipine was used as the model drug...
February 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28254729/correlation-study-on-chromogranin-a-genetic-polymorphism-and-prognosis-of-critically-ill-patients
#15
Jing-Lun Liu, Xiao-Ying Chen, Ni-Na Gu, Jin-Ye Zhang, Li-Ping Jiang, Dan Zhang, Guo-Sheng Ren
OBJECTIVE: The objective was to investigate the correlation between single nucleotide polymorphism (SNP) of chromogranin A (CHGA) and prognosis of critically ill patients. METHODS: We screened 357 critically ill patients consecutively admitted to our intensive care unit. The -89/-415/-462 SNP locus in the promoter region and the +9559/+9578/+9590/+9611 SNP locus in exon 7 coding of CHGA were genotyped by polymerase chain reaction and DNA sequencing technology. Subsequently, the correlation between genotype and prognosis of patients was analyzed...
June 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28153559/clinical-and-laboratory-features-of-the-most-common-clostridium-difficile-ribotypes-isolated-in-belgium
#16
F Neely, M-L Lambert, J Van Broeck, M Delmée
BACKGROUND: Previous studies comparing Clostridium difficile infection (CDI) due to different ribotypes have been conflicting, and many have only compared small numbers of cases or few ribotypes. AIM: To compare patient and episode characteristics for CDI due to different ribotypes. METHODS: The ribotyping results from 3333 toxin-producing isolates collected from 110 Belgian hospitals between October 2010 and December 2015 were matched to clinical data from the national CDI surveillance database...
April 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27749810/importance-of-urine-dipstick-in-evaluation-of-young-febrile-infants-with-positive-urine-culture-a-spanish-pediatric-emergency-research-group-study
#17
MULTICENTER STUDY
Roberto Velasco, Helvia Benito, Rebeca Mozun, Juan E Trujillo, Pedro A Merino, Mercedes de la Torre, Borja Gomez, Santiago Mintegi
BACKGROUND AND OBJECTIVES: Guidelines from the American Academy of Pediatrics define urinary tract infection (UTI) as the growth of greater than 50,000 ufc/mL of a single bacterium in a urine culture with a positive urine dipstick or with a urinalysis associated. Our objective was to evaluate the adequacy of this cutoff point for the diagnosis of UTI in young febrile infants. METHODS: Subanalysis of a prospective multicenter study developed in RISeuP-SPERG Network between October 11 and September 13...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27714578/jennifer-w-shewmaker-sexualized-media-messages-and-our-children-teaching-kids-to-be-smart-critics-and-consumers-praeger-santa-barbara-ca-2015-182-pp-isbn-978-1-4408-3333-5
#18
https://www.readbyqxmd.com/read/27597413/development-of-highly-potent-phosphodiesterase-4-inhibitors-with-anti-neuroinflammation-potential-design-synthesis-and-structure-activity-relationship-study-of-catecholamides-bearing-aromatic-rings
#19
Zhong-Zhen Zhou, Bing-Chen Ge, Qiu-Ping Zhong, Chang Huang, Yu-Fang Cheng, Xue-Mei Yang, Hai-Tao Wang, Jiang-Ping Xu
In this study, catecholamides (7a-l) bearing different aromatic rings (such as pyridine-2-yl, pyridine-3-yl, phenyl, and 2-chlorophenyl groups) were synthesized as potent phosphodiesterase (PDE) 4 inhibitors. The inhibitory activities of these compounds were evaluated against the core catalytic domains of human PDE4 (PDE4CAT), full-length PDE4A4, PDE4B1, PDE4C1, and PDE4D7 enzymes, and other PDE family members. Eight of the synthesized compounds were identified as having submicromolar IC50 values in the mid-to low-nanomolar range...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27525874/development-of-novel-polymorphic-microsatellite-markers-in-siganus-fuscescens
#20
X Q Mao, Z B Li, Y F Ning, J B Shangguan, Y Yuan, Y S Huang, B B Li
Rabbitfish, Siganus fuscescens, is widely distributed in the Indo-Pacific regions and eastern Mediterranean. Its dwelling place includes reef flats, coral reef regions, and seagrass meadows in tropical area and reef areas or shallow waters in locations at high latitudes. In the present study, 10 new polymorphic microsatellite markers were screened from 30 wild S. fuscescens individuals, using a method of fast isolation protocol and amplified fragment length polymorphism of sequences containing repeats. The number of polymorphic alleles per locus was 3 to 5 with a mean of 4...
July 29, 2016: Genetics and Molecular Research: GMR
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