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https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#1
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29603916/phase-1-pharmacokinetics-and-phase-3-efficacy-of-testosterone-nasal-gel-in-subjects-with-seasonal-allergies
#2
Alan D Rogol, Natalia Tkachenko, Philipp Badorrek, Jens M Hohlfeld, Nathan Bryson
INTRODUCTION: NATESTO® testosterone nasal gel (TNG) is a liquid gel that is applied in the nose for the treatment of male hypogonadism. There is a reasonable concern that administration of TNG to patients with active rhinitis could modify absorption. Results from two clinical studies are reported wherein subjects with allergic rhinitis (AR) subjects are treated with TNG. METHODS: The 24-hour pharmacokinetics (PK) and relative bioavailability of serum total testosterone (sTT) from TNG (11 mg tid ) were determined using a phase 1 Latin-square design with 18 eugonadal AR subjects crossed over between asymptomatic, symptomatic-untreated, and symptomatic-treated (oxymetazoline) conditions...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29551533/immunotherapy-with-the-sq-tree-slit-tablet-in-adults-and-adolescents-with-allergic-rhinoconjunctivitis
#3
Mika J Mäkelä, Pär Gyllfors, Erkka Valovirta, Maria A Steffensen, Pernille M Grønager, Johannes Savolainen, Lone Winther
PURPOSE: The SQ tree sublingual immunotherapy (SLIT)-tablet containing allergen extracts with the major allergen Bet v 1 from birch pollen is currently being developed for the treatment of tree pollen-induced allergic rhinitis/conjunctivitis with or without asthma. The aim of this Phase II trial was to investigate the dose-related efficacy and safety of the SQ tree SLIT-tablet. METHODS: This study was a randomized, parallel-group, double-blind, placebo-controlled, multi-national trial conducted in Europe...
March 15, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29447897/pattern-of-allergic-rhinitis-among-children-in-ekiti-nigeria
#4
Waheed Atilade Adegbiji, Gabriel Toye Olajide, Anthony Oyebanji Olajuyin, Shuaib Kayode Aremu, Akanbi Ganiyu Olusola
BACKGROUND: Allergic rhinitis is a chronic and recurrent nasal condition. It is often neglected in children with late presentation. This study aimed at determining the prevalence, sociodemographic features, comorbid illnesses, complications and quality of life in children with allergic rhinitis in the study institution. MATERIALS AND METHODS: This is a prospective hospital based study of children with allergic rhinitis in Ekiti state university teaching hospital, Ado Ekiti...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29446469/clinical-trials-in-allergen-immunotherapy-current-concepts-and-future-needs
#5
REVIEW
O Pfaar, M Alvaro, V Cardona, E Hamelmann, R Mösges, J Kleine-Tebbe
Allergen immunotherapy (AIT) is a safe, effective treatment for allergic rhinoconjunctivitis and allergic asthma. However, AIT's clinical effect is still contested - primarily due to heterogeneity in clinical trial designs, study populations, therapeutic formulations and efficacy criteria. After discussing current concepts and unmet needs, an international panel of experts made several recommendations: (i) explore and validate definitions for [clinical] responders in AIT-trials; (ii) use of well-documented, standardized provocation tests prior to inclusion of subjects with relevant diseases in AIT trials; (iii) monitoring neo-sensitizations and occurrence of new allergy in extended AIT trials, and exclusion of polyallergic participants; (iv) validation of allergen exposure chambers with regard to natural exposure; (v) in studies of seasonal allergies, focus on peak exposure but also consider organising two parallel, geographically distinct but otherwise identical trials; (vi) discuss adaptive trial designs with the regulatory authorities; (vii) use e-health and m-health technologies to capture more information on individual exposure to allergens; (viii) initiate research on potential psychological, biochemical, immune, neural and even genomic markers of the placebo response; (ix) identify trial designs and primary endpoints that will give children with allergies easier, faster access to AIT formulations; and (x) promote and apply standardized methods for reporting systemic and local adverse events...
February 15, 2018: Allergy
https://www.readbyqxmd.com/read/29434271/adherence-and-quality-of-life-in-adults-and-children-during-3-years-of-slit-treatment-with-grazax-a-real-life-study
#6
Hampus Kiotseridis, Peter Arvidsson, Vibeke Backer, Vagn Braendholt, Alf Tunsäter
Respiratory allergic disease represents a global health problem, 30% of the population suffers from allergic rhinoconjunctivitis and 20% suffer from asthma. Allergy immunotherapy induce immunological tolerance and thereby modify the response to allergens and sublingual immunotherapy (SLIT) offers the possibility of home administration of allergen therapy, but adherence is more uncertain. The aim of the study was to investigate the adherence with GRAZAX in adults and children ≥ 5 years during three consecutive years of treatment...
February 12, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29422821/twenty-years-observation-of-subcutaneous-pollen-allergoid-immunotherapy-efficacy-in-adults
#7
Andrzej Bożek, Izabella Krupa-Borek, Jerzy Jarzab
Introduction: It is valuable to determine the long-term efficacy of allergen-specific immunotherapy (SIT) and whether it can cure allergy. Aim: For this study, patients were prospectively observed for 20 years after completion of SIT to determine its effectiveness. Material and methods: A total of 1006 patients who underwent SIT for pollen allergy were observed for 20 years to assess the efficacy of SIT. The rhinitis symptom score (RSS) and asthma symptom score (ASS) were measured after SIT completion...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29402620/monitoring-of-mycoflora-in-outdoor-air-of-different-localities-of-ahvaz-iran
#8
M Fatahinia, A Zarei-Mahmoudabadi, H Shokri, H Ghaymi
INTRODUCTION: Airborne fungi are considered important causes of respiratory allergy and diseases. The knowledge of these fungi in a city or region is important for the ecological diagnosis and specific treatment of respiratory manifestations induced by inhalation of fungal agents. Therefore, in recent years bioaerosols and their density in the air is highly regarded. Identifying fungi with common mycological methods as well as molecular about 5% of people are prone to allergic symptoms of the respiratory tract caused by molds during their lives...
February 2, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29379542/clinical-and-immunological-effects-of-vitamin-d-supplementation-during-the-pollen-season-in-children-with-allergic-rhinitis
#9
Joanna Jerzyńska, Włodzimierz Stelmach, Błażej Rychlik, Paweł Majak, Daniela Podlecka, Katarzyna Woicka-Kolejwa, Iwona Stelmach
Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis. Material and methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Children received either vitamin D 1000 IU daily supplementation or placebo...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29361332/safety-and-efficacy-of-immunotherapy-with-the-recombinant-b-cell-epitope-based-grass-pollen-vaccine-bm32
#10
Verena Niederberger, Angela Neubauer, Philippe Gevaert, Mihaela Zidarn, Margitta Worm, Werner Aberer, Hans Jørgen Malling, Oliver Pfaar, Ludger Klimek, Wolfgang Pfützner, Johannes Ring, Ulf Darsow, Natalija Novak, Roy Gerth van Wijk, Julia Eckl-Dorna, Margarete Focke-Tejkl, Milena Weber, Hans-Helge Müller, Joachim Klinger, Frank Stolz, Nora Breit, Rainer Henning, Rudolf Valenta
BACKGROUND: BM32 is a grass pollen allergy vaccine based on recombinant fusion proteins consisting of nonallergenic peptides from the IgE-binding sites of the 4 major grass pollen allergens and the hepatitis B preS protein. OBJECTIVE: We sought to study the safety and clinical efficacy of immunotherapy (allergen immunotherapy) with BM32 in patients with grass pollen-induced rhinitis and controlled asthma. METHODS: A double-blind, placebo-controlled, multicenter allergen immunotherapy field study was conducted for 2 grass pollen seasons...
January 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29340327/trimethoprim-sulfamethoxazole-reduces-rates-of-melioidosis-in-high-risk-hemodialysis-patients
#11
Sandawana William Majoni, Jaquelyne T Hughes, Bianca Heron, Bart J Currie
Introduction: Melioidosis causes sepsis and death in the Top End of Northern Australia during the monsoonal wet season. Dialysis-dependent adults suffer higher melioidosis rates compared to low rates among renal transplant patients who routinely receive trimethoprim+sulfamethoxazole prophylaxis. Methods: We performed a prospective interventional study to determine the efficacy and safety of daily trimethoprim+sulfamethoxazole prophylaxis in hemodialysis patients during the wet season, from 1 November 2014 to 30 April 2015...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29315922/the-use-of-omalizumab-in-allergen-immunotherapy
#12
REVIEW
J A Dantzer, R A Wood
Although omalizumab (anti-IgE) is currently only approved for the treatment of asthma and chronic idiopathic urticaria, it has also been studied as an off-label treatment for numerous allergic conditions, including use as an adjunct to allergen immunotherapy in the treatment of allergic rhinitis, asthma, venom hypersensitivity and food allergy. We conducted a review of publications involving the use of omalizumab with allergen immunotherapy, by searching PubMed with key search terms of "omalizumab" and "immunotherapy...
March 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29279062/comparison-of-the-effect-of-5-grass-pollen-sublingual-immunotherapy-tablets-and-drops-in-children-with-rhinoconjunctivitis
#13
Joanna Jerzynska, Wlodzimierz Stelmach, Pawel Majak, Rafal Stelmach, Anna Janas, Iwona Stelmach
BACKGROUND: One of the most important aspects of sublingual immunotherapy (SLIT) is the regimen of administration. AIM: To find any differences in symptom-medication scores between the two groups of SLIT tablets and drops, given pre-coseasonally (starting 8 weeks before the pollen season) in children with rhinoconjunctivitis allergy to grass pollen. The secondary outcome were the differences in lung function and induction of T-regulatory forkhead box P3 (FOXP3) positive cells...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29181536/pharmacologic-treatment-of-seasonal-allergic-rhinitis-synopsis-of-guidance-from-the-2017-joint-task-force-on-practice-parameters
#14
Dana V Wallace, Mark S Dykewicz, John Oppenheimer, Jay M Portnoy, David M Lang
Description: The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or older. Methods: To update a prior systematic review, the workgroup searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 18 July 2012 to 29 July 2016 to identify studies that addressed efficacy and adverse effects of single or combination pharmacotherapy for seasonal allergic rhinitis...
December 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29055045/diagnostic-relevance-of-ige-sensitization-profiles-to-eight-recombinant-phleum-pratense-molecules
#15
Francesca Cipriani, Carla Mastrorilli, Salvatore Tripodi, Giampaolo Ricci, Serena Perna, Valentina Panetta, Riccardo Asero, Arianna Dondi, Annamaria Bianchi, Nunzia Maiello, Michele Miraglia Del Giudice, Tullio Frediani, Francesco Macrì, Sandra Lucarelli, Iride Dello Iacono, Maria Francesca Patria, Elena Varin, Diego Peroni, Loredana Chini, Viviana Moschese, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Mariangela Tosca, Francesco Paravati, Ifigenia Sfika, Andrea Di Rienzo Businco, Calotta Povesi Dascola, Pasquale Comberiati, Simone Frediani, Caterina Lambiase, Maria Carmen Verga, Diego Faggian, Mario Plebani, Mauro Calvani, Carlo Caffarelli, Paolo Maria Matricardi
BACKGROUND: Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. METHODS: We examined 1120 children (age 4-18y) with SARg...
October 20, 2017: Allergy
https://www.readbyqxmd.com/read/28994183/angiotensin-converting-enzyme-inhibitor-induced-angioedema-a-review-of-the-literature
#16
REVIEW
Teresa Brown, Jimmy Gonzalez, Catherine Monteleone
According to the National Health and Nutrition Examination Survey 2012, one third of antihypertensive prescriptions in the United States in the past decade were for angiotensin-converting enzyme inhibitors (ACEIs). An important and serious side effect of ACEIs is angioedema caused by a reduction in bradykinin degradation. In a national medical chart abstraction study conducted at the US Veterans Affairs Health Care System in 2008, 0.20% of ACEI initiators developed angioedema while on the medication. The angiotensin-converting enzyme is a part of the renin-angiotensin system that converts angiotensin I to angiotensin II...
December 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28990893/-pollen-food-allergy-syndrome
#17
REVIEW
Özlem Kar Kurt, Mustafa Erkoçoğlu, Mevlüt Kurt
Pollen food allergy syndrome, is a type I cross-reaction mediated by IgE antibodies between an aeroallergen and a plant-derived antigen. Main symptoms are typically consist of localized oral symptoms such as numbness of the lip or mouth, itching, tingling and swelling of lips, tongue, palate and pharynx without systemic symptoms. Patients with seasonal allergic rhinitis, asthma or both more frequently experience pollen food allergy syndrome. Because most patients have mild symptoms and the improvement by avoiding food, the true incidence is unknown...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28940458/eaaci-guidelines-on-allergen-immunotherapy-allergic-rhinoconjunctivitis
#18
G Roberts, O Pfaar, C A Akdis, I J Ansotegui, S R Durham, R Gerth van Wijk, S Halken, D Larenas-Linnemann, R Pawankar, C Pitsios, A Sheikh, M Worm, S Arasi, M A Calderon, C Cingi, S Dhami, J L Fauquert, E Hamelmann, P Hellings, L Jacobsen, E F Knol, S Y Lin, P Maggina, R Mösges, J N G Oude Elberink, G B Pajno, E A Pastorello, M Penagos, G Rotiroti, C B Schmidt-Weber, F Timmermans, O Tsilochristou, E-M Varga, J N Wilkinson, A Williams, L Zhang, I Agache, E Angier, M Fernandez-Rivas, M Jutel, S Lau, R van Ree, D Ryan, G J Sturm, A Muraro
Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect...
September 23, 2017: Allergy
https://www.readbyqxmd.com/read/28928804/efficacy-of-a-leukotriene-receptor-antagonist-for-pediatric-cedar-pollen-allergy-complicated-by-asthma
#19
Shigemi Yoshihara, Yutaka Kikuchi, Mari Saitou, Susumu Yanagawa, Noriko Kanno, Hiroshi Igarashi, Hironobu Fukuda, Akiko Iimura, Toshio Abe, Yumi Yamada, Tamotsu Andou, Osamu Arisaka
Leukotriene receptor antagonists (LTRAs) are identified as a monotherapy for asthma and allergic rhinitis; however, their use in children for treatment of these diseases has not been examined. Accordingly, the present study investigated the efficacy of pranlukast dry syrup for children with both pollinosis and asthma. The subjects were children receiving treatment for asthma who were also diagnosed with cedar pollen allergy. Patients were divided into a group that received continuous treatment with pranlukast (group A; n=20) and a group that commenced add-on treatment for pollinosis following the onset of symptoms (group B; n=20)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28890019/allergic-sensitization-and-objective-measures-of-sleep-in-urban-school-aged-children-with-asthma
#20
Cynthia A Esteban, Robin S Everhart, Sheryl J Kopel, Robert B Klein, Daphne Koinis-Mitchell
BACKGROUND: Allergic sensitization is associated with increased child asthma morbidity and decreased pulmonary function. Nocturnal symptoms and/or awakenings typically are measured by self-report from diary data, whereas objective assessments of sleep in child asthma studies are lacking. OBJECTIVE: To investigate the association between increased allergic sensitization (number of positive allergy test results measured by skin prick test or specific immunoglobulin E) and sleep outcomes (sleep efficiency, sleep duration, and mean number of awakenings measured by actigraphy) in urban schoolchildren with persistent asthma...
September 2017: Annals of Allergy, Asthma & Immunology
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