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https://www.readbyqxmd.com/read/28655148/genetic-variants-in-the-manganese-superoxide-dismutase-2-gene-and-in-the-catalase-gene-are-not-associated-with-alcoholic-chronic-pancreatitis
#1
Alexander Schneider, Jonas Rosendahl, Peter Bugert, Christel Weiss, Heike Unterschütz, Marja-Leena Kylanpää-Bäck, Marko Lempinen, Esko Kemppainen, Brindusa L Diaconu, Matthias P Ebert, Roland H Pfützer
Aims: Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636...
June 26, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28654021/vitamin-c-aging-and-alzheimer-s-disease
#2
REVIEW
Fiammetta Monacelli, Erica Acquarone, Chiara Giannotti, Roberta Borghi, Alessio Nencioni
Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28654017/does-vitamin-c-influence-neurodegenerative-diseases-and-psychiatric-disorders
#3
REVIEW
Joanna Kocot, Dorota Luchowska-Kocot, Małgorzata Kiełczykowska, Irena Musik, Jacek Kurzepa
Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28653920/antibacterial-and-antioxidant-properties-of-various-solvents-extracts-of-abutilon-theophrasti-medic-leaves
#4
Chunlian Tian, Caixia Yang, Dexian Zhang, Limei Han, Yaochuan Liu, Wenjie Guo, Ruiming Fan, Mingchun Liu
This paper described the extraction procedure of six extracts from Abutilon theophrasti Medic. leaves and evaluated antioxidant and antibacterial activity of different extracts by hydroxyl radical, DPPH radical scavenging, broth micro-dilution and agar-well diffusion methods. The six extracts were prepared by the two extraction procedures: (I) water was the extraction solvent; (II) 90% alcohol extract was extracted by petroleum ether, chloroform, ethyl acetate and n-butanol in turn. Extract yields were 7.34%, 7...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653919/dpph-abts-free-radical-scavenging-antibacterial-and-phytochemical-evaluation-of-crude-methanolic-extract-and-subsequent-fractions-of-chenopodium-botrys-aerial-parts
#5
Farhat Ullah, Naveed Iqbal, Muhammad Ayaz, Abdul Sadiq, Ihsan Ullah, Sajjad Ahmad, Muhammad Imran
We investigated antioxidant, antibacterial potentials and secondary metabolites of Chenopodium botrys aerial parts to rationalize its effectiveness in free radicals induced disorders and infectious diseases. Antioxidant activity of plant extracts were investigated using DPPH and ABTS free radicals scavenging assays. Antibacterial potential was studied using well diffusion method. Phytochemical analysis was performed for the presence of secondary metabolites. In DPPH assay chloroform fraction (CHF), ethyl acetate fraction (EAF) and n-hexane fraction (NHF) were most active causing average inhibition of 65...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653902/nf-%C3%AE%C2%BAb-as-the-main-node-of-resistance-to-receptor-tyrosine-kinase-inhibitors-in-triple-negative-breast-cancer
#6
Behrad Darvishi, Leila Farahmand, Zahra Eslami-S, Keivan Majidzadeh-A
Graphical abstract Although accounting for merely a minute portion of diagnosed breast cancers, disproportionate number of deaths and associated low survival rate of patients have made triple-negative breast cancer to be considered as the most lethal breast cancer subtype. More importantly, intrinsic or developed resistance to chemotherapeutic regimens and disappointing outcomes of trials associated with many newly developed agents are other obstacles in establishment of a durable response in these patients...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653243/novel-concepts-of-ms-cleavable-cross-linkers-for-improved-peptide-structure-analysis
#7
Christoph Hage, Francesco Falvo, Mathias Schäfer, Andrea Sinz
The chemical cross-linking/mass spectrometry (MS) approach is gaining increasing importance as an alternative method for studying protein conformation and for deciphering protein interaction networks. This study is part of our ongoing efforts to develop innovative cross-linking principles for a facile and efficient assignment of cross-linked products. We evaluate two homobifunctional, amine-reactive, and MS-cleavable cross-linkers regarding their potential for automated analysis of cross-linked products. We introduce the bromine phenylurea (BrPU) linker that possesses a unique structure yielding a distinctive fragmentation pattern on collisional activation...
June 26, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28652782/hepatic-artery-infusion-chemotherapy-improved-survival-of-hepatocellular-carcinoma-after-radical-hepatectomy
#8
Min Feng, Chengwu Tang, Wenming Feng, Ying Bao, Yinyuan Zheng, Jianbin Shen
OBJECTIVE: To evaluate the effect of postoperative hepatic artery-infusion chemotherapy (HAIC) on survival probability in patients with hepatocellular carcinoma (HCC) after radical hepatectomy. PATIENTS AND METHODS: This retrospective study included 85 patients with HCC who received radical hepatectomy from May 2005 to May 2010. Among these patients, 42 underwent two sessions of HAIC (5-fluoruracil [1,000 mg/m(2)], oxaliplatin [85 mg/m(2)], and mitomycin-C [6 mg/m(2)]) after radical hepatectomy (HAIC group), and 43 underwent radical hepatectomy only (the control group)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652542/therapeutic-potential-of-ghrelin-and-des-acyl-ghrelin-against-chemotherapy-induced-cardiotoxicity
#9
Miki Nonaka, Nagomi Kurebayashi, Takashi Murayama, Masami Sugihara, Kiyoshi Terawaki, Seiji Shiraishi, Kanako Miyano, Hiroshi Hosoda, Shosei Kishida, Kenji Kangawa, Takashi Sakurai, Yasuhito Uezono
Cancer was considered an incurable disease for many years; however, with the development of anticancer drugs and state-of-the art technologies, it has become curable. Cardiovascular diseases in patients with cancer or induced by cancer chemotherapy have recently become a great concern. Certain anticancer drugs and molecular targeted therapies cause cardiotoxicity, which limit the widespread implementation of cancer treatment and decrease the quality of life in cancer patients significantly. The anthracycline doxorubicin (DOX) causes cardiotoxicity...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28651460/-gut-liver-axis-in-inflammatory-bowel-disease-a-retrospective-study
#10
Anna Egresi, Ágota Kovács, Ágnes Szilvás, Anna Blázovics
INTRODUCTION: Examination of the gut-liver axis came into the spotlight worldwide. Liver enzyme elevations are commonly seen in patients with inflammatory bowel disease (IBD), which is a diagnostic challenge in everyday clinical practice. Liver and biliary diseases are common extra-intestinal manifestations in Crohn's disease and ulcerative colitis. The assessment of routine liver function tests could be an inaccurate reflection of liver damage, so its prevalence could be underestimated...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28651044/the-atmospheric-fate-of-monoethanolamine-enhancing-new-particle-formation-of-sulfuric-acid-as-an-important-removal-process
#11
Hong-Bin Xie, Jonas Elm, Roope Halonen, Nanna Myllys, Theo Kurtén, Markku Kulmala, Hanna Vehkamaki
Monoethanolamine (MEA), a potential atmospheric pollutant from capture unit of a leading CO2 capture technology, could be removed by participating H2SO4-based new particle formation (NPF) as simple amines. Here we evaluated the enhancing potential of MEA on H2SO4-based NPF by examining the formation of molecular clusters of MEA and H2SO4 using a combined quantum chemistry calculations and kinetics modeling. The results indicate that MEA at ppt-level can enhance H2SO4-based NPF. The enhancing potential of MEA is < dimethylamine (DMA), one of the strongest enhancing agents, and ≫ methylamine (MA), in contrast to the order suggested solely by their basicity (MEA < MA < DMA)...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28650666/labile-incorporation-of-cholesterol-terminated-poly-acrylic-acid-for-the-facile-surface-modification-of-lipid-vesicles
#12
Sang-Min Lee
An amphiphilic cholesterol-terminated poly[acrylic acid] (Chol-PAA) that can be self-aggregated into nanoscale micelles in aqueous media has been prepared via nitroxide-mediated radical polymerization for the facile postformation modification of lipid vesicles. By varying the amount of Chol-PAA addition, the incorporation of Chol-PAA on the liposome templates was verified with zeta potential while the dynamic light scattering measurements revealed the polymer length of Chol-PAA dictated the hydrodynamic diameter of the resulting polymer-grafted vesicles (PGVs)...
June 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28650489/1-2-arylalkylation-of-n-arylsulfonyl-acrylamides-using-aliphatic-aldehydes-as-the-alkyl-source
#13
Jin-Tao Yu, Rongzhen Chen, Jiawei Zhu, Jiang Cheng
A metal-free decarbonylative arylalkylation of N-(arylsulfonyl)acrylamides using aliphatic aldehydes as the alkyl radical source was developed, providing a series of α-aryl-β-alkylamides in moderate to good yields. In this reaction, concomitant alkylation, aryl migration and desulfonylation were involved.
June 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28649826/increasing-cancer-therapy-efficiency-through-targeting-and-localized-light-activation
#14
Yuqi Yang, Shizhen Chen, Lianhua Liu, Sha Li, Qingbin Zeng, Xiuchao Zhao, Haidong Li, Zhiying Zhang, Louis-S Bouchard, Maili Liu, Xin Zhou
Currently, the potential of cancer therapy is compromised by a variety of problems related to tumor specificity, drug access, and limited efficacy. We report a novel approach to improve the effectiveness of cancer treatment utilizing a light-responsive nanoconstruct. Effectiveness is increased by enhancing drug absorption through heating and the production of free radicals. Treatment specificity is increased through chemical targeting of the nanoconstruct and localization of the light delivery to the tumor...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28649767/the-use-of-antioxidant-agents-for-chemotherapy-induced-peripheral-neuropathy-treatment-in-animal-models
#15
REVIEW
Larissa Feitosa Carvalho, Ana Maria Fantini Silva, Adriana Andrade Carvalho
Antineoplastic drugs such as Cisplatin, Oxaliplatin, Paclitaxel and Vincristin are widely used in the treatment for several both solid and blood tumours. However, the severity of peripheral neuropathy caused by these agents can affect the patient's quality of life. The major symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN) involve: sensory loss, paresthesia, dysesthaesia, numbness, tingling, temperature sensitivity, allodynia and hyperalgesia, in a "stocking and glove" distribution. Why many different chemotherapeutic agents result in similar neuropathy profiles is unclear...
June 26, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28649636/interplay-of-space-radiation-and-microgravity-in-dna-damage-and-dna-damage-response
#16
María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, Honglu Wu
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms. Specifically, space radiation can cause damage to DNA directly, through the interaction of charged particles with the DNA molecules themselves, or indirectly through the production of free radicals. Although organisms have evolved strategies on Earth to confront such damage, space environmental conditions, especially microgravity, can impact DNA repair resulting in accumulation of severe DNA lesions...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649567/effect-of-dark-chocolate-extracts-on-phorbol-12-myristate-13-acetate-induced-oxidative-burst-in-leukocytes-isolated-by-normo-weight-and-overweight-obese-subjects
#17
Francesca Ioannone, Giampiero Sacchetti, Mauro Serafini
Oxidative and inflammatory stress represents a major risk factor for cardiovascular disease (CVD) in overweight and obese subjects. Between the different plant foods, chocolate has been shown to decrease CVD risk due to its antioxidant and anti-inflammatory properties. However, as we recently showed in epidemiological studies, meta-analyses, and human trials, dietary antioxidants resulted more effective in subjects characterized by an ongoing oxidative stress, than in healthy people. Aim of this work was to investigate the effect of different concentrations of chocolate phenolic extract (CPE) on in vitro free radical production, stimulated by phorbol 12-myristate 13-acetate (PMA), in leukocytes extracted from blood of normo-weight and overweight/obese subjects...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28649063/isolation-of-phytoconstituents-and-evaluation-of-anticancer-and-antioxidant-potential-of-launaea-mucronata-forssk-muschl-subsp
#18
Eman R Elsharkawy
Traditional Medicine is widely used in clinical research due to its low toxicity, low number of side effects, and low cost. Many components of common fruits and vegetables play well-documented roles as chemo preventive or chemotherapeutic agents that suppress tumor genesis. The present study was aimed to identify the DPPH (2, 2-diphenyl-1-picrylhydrazyl) free-radical scavenging constituents from methanol extract of Launaea mucronata using bioassay-guided fractionation. The methanolic extract revealed a strong antioxidant activity, the IC50 values (the concentration with scavenging activity of 50%) was 25...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648977/prognostic-relevance-of-lymph-node-status-for-patients-with-ampullary-adenocarcinoma-after-radical-resection-followed-by-adjuvant-treatment
#19
J Kwon, K Kim, E K Chie, B H Kim, J-Y Jang, S W Kim, D-Y Oh, Y-J Bang
PURPOSE: Attempts have been made to revise the nodal stage due to simplicity of current N staging system in ampullary adenocarcinoma. However, because of the disease rarity, there have only been a few studies assessing the prognostic impact of lymph node (LN) parameters. METHODS: We retrospectively analyzed 120 patients who underwent radical resection followed by adjuvant chemoradiotherapy for ampullary adenocarcinoma. The effect of LN parameters (number of total harvest LNs, number of metastatic LN (MLN), lymph node ratio (LNR), and log odds of positive LNs (LODDS)) on overall survival (OS), locoregional relapse-free survival (LRFS) and distant metastasis-free survival were evaluated...
June 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28648804/the-single-igf-1-partial-deficiency-is-responsible-for-mitochondrial-dysfunction-and-is-restored-by-igf-1-replacement-therapy
#20
M Olleros Santos-Ruiz, M C Sádaba, I Martín-Estal, U Muñoz, C Sebal Neira, I Castilla-Cortázar
BACKGROUND & AIMS: We previously described in cirrhosis and aging, both conditions of IGF-1 deficiency, a clear hepatic mitochondrial dysfunction with increased oxidative damage. In both conditions, the hepatic mitochondrial function was improved with low doses of IGF-1. The aim of this work was to explore if the only mere IGF-1 partial deficiency, without any exogenous insult, is responsible for hepatic mitochondrial dysfunction. METHODS: Heterozygous (igf1(+/-)) mice were divided into two groups: untreated and treated mice with low doses of IGF-1...
June 2, 2017: Growth Hormone & IGF Research
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