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https://www.readbyqxmd.com/read/28350967/molecular-hydrogen-potentiates-beneficial-anti-infarct-effect-of-hypoxic-postconditioning-in-isolated-rat-hearts-novel-cardioprotective-intervention
#1
Marek Zálešák, Branislav Kura, Ján Graban, Veronika Ledvényiová-Farkašová, Jan Slezak, Tatiana Ravingerova
Generation of free radicals through incomplete reduction of oxygen during ischemia/ reperfusion is well-described. On the other hand, molecular hydrogen (H<sub>2</sub>) reduces oxidative stress due to its ability to react with strong oxidants and easily penetrate cells by diffusion, without disturbing metabolic redox reactions. This study was designed to explore cardioprotective potential of hypoxic postconditioning (HpostC) against ischemia/reperfusion (30-min global I/120-min R) in isolated rat hearts using oxygen-free Krebs-Henseleit buffer (KHB)...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350623/ocular-surface-squamous-neoplasia-in-papillon-lef%C3%A3-vre-syndrome-outcome-at-long-term-follow-up-of-12-years
#2
Swathi Kaliki, Swati Singh, Swarnalata Gowrishankar, Vijay Anand P Reddy
PURPOSE: To discuss the association between ocular surface squamous neoplasia (OSSN) and Papillon-Lefèvre syndrome (PLS) and present the long-term outcome in a patient with these diseases. METHODS: Case report. RESULTS: A 14-year-old boy presented with a raised pigmented mass lesion at the limbus in the right eye, which was clinically suggestive of OSSN. He also had palmoplantar hyperkeratosis and periodontosis suggestive of PLS. Excision biopsy of the lesion confirmed the diagnosis of OSSN...
March 21, 2017: Cornea
https://www.readbyqxmd.com/read/28350536/anti-inflammatory-effects-and-anti-oxidant-capacity-of-myrathius-arboreus-cecropiaceae-in-experimental-models
#3
Oluwafemi Gabriel Oluwole, Olufunmilayo Ologe, Akinyinka Alabi, Ganiyu Tunde Yusuf, Solomon Umukoro
BACKGROUND: Inflammation is involved in various diseases; search for safe treatments is warranted. Anti-inflammatory effects of ethanol extract of Myrathius arboreus (EEMa) were studied in carrageenan-induced model, formaldehyde sub-acute-induced model, and in 48 h lipopolysaccharide-induced air pouch model of inflammation. EEMa membrane-stabilizing activities and anti-oxidant capacity were determined in vitro. METHODS: In the carrageenan model EEMa (125, 250, or 500 mg/kg), indomethacin (5 mg/kg), or vehicle 3 mL/kg was administered orally in rats (n=5)...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28346925/microbiota-and-necrotizing-enterocolitis
#4
Sanjay Patole
Necrotizing enterocolitis (NEC) is an acquired gastrointestinal inflammatory condition with significant mortality and morbidity in preterm very low birth weight infants. The interplay between toll-like receptors, bacterial endotoxins, developmentally regulated excessive proinflammatory responses of the immature innate immune system, hypoxia, ischemia, reperfusion, free radicals, and the presence of substrates and bacterial endotoxins is thought to play an important role in the pathogenesis of NEC. The association (cause?) of various microbes (bacteria, viruses, and fungi) with NEC has intrigued researchers for many years...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346806/active-surveillance-in-younger-men-with-prostate-cancer
#5
Michael S Leapman, Janet E Cowan, Hao G Nguyen, Katsuto K Shinohara, Nannette Perez, Matthew R Cooperberg, William J Catalona, Peter R Carroll
Purpose The suitability of younger patients with prostate cancer (PCa) for initial active surveillance (AS) has been questioned on the basis of eventual treatment necessity and concerns of safety; however, the role of age on surveillance outcomes has not been well defined. Patients and Methods We identified men managed with AS at our institution with a minimum follow-up of 6 months. The primary study objective was to examine the association of age with risk of biopsy-based Gleason score upgrade during AS. We also examined the association of age with related end points, including overall biopsy-determined progression, definitive treatment, and pathologic and biochemical outcomes after delayed radical prostatectomy (RP), using descriptive statistics, the Kaplan-Meier method, and multivariable Cox proportional hazards regression...
March 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28346559/mechanism-of-degradation-of-a-nitrogenous-heterocycle-induced-by-a-reductive-radical-decomposition-of-a-sym-triazine-ring
#6
Gengxin Lyu, Guosheng Shi, Liang Tang, Haiping Fang, Minghong Wu
Cyanuric acid is a major component of many materials and chemicals, and is the most important intermediate in the degradation processes of sym-triazine compounds in the natural environment, as well as being used for water treatment. However, the degradation mechanism of cyanuric acid is still unclear in various advanced oxidation processes (AOPs), where ˙OH is usually regarded as the dominant radical. Here, using a combination of density functional theory calculations and experimental observations, we unexpectedly show that the sym-triazine ring structure is broken efficiently by reductive free radicals - hydrogen radicals (˙H), rather than traditional ˙OH...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28345821/antioxidant-and-antiproliferative-activities-of-an-ethylacetate-fraction-of-picria-fel-terrae-lour-herbs
#7
Denny Satria, Jansen Silalahi, Ginda Haro, Syafruddin Ilyas, Poppy Anjelisa Z Hsb
Background: Excessive production of oxygen free radicals and imbalance in the mechanisms responsible for antioxidant protection may result in the onset of many diseases including breast cancer. Objective: To evaluate antiproliferative and antioxidant activity of an ethylacetate fraction (EAF) of Picria fel-terrae Lour. Herbs in the T47D cell line. Methods: Phenolic and total flavonoid contents in EAF were determined. EAF was tested for cytotoxicity and effects on the cell cycle and apoptosis, as well as antioxidant activity...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345352/metal-free-photoinduced-electron-transfer-atom-transfer-radical-polymerization-integrated-with-bio-inspired-polydopamine-chemistry-as-a-green-strategy-for-surface-engineering-of-magnetic-nanoparticles
#8
Yang Yang, Xuegang Liu, Gang Ye, Shan Zhu, Zhe Wang, Xiaomei Huo, Krzysztof Matyjaszewski, Yuexiang Lu, Jing Chen
Developing green and efficient technologies for surface modification of magnetic nanoparticles (MNPs) is of crucial importance for their biomedical and environmental applications. This study reports, for the first time, a novel strategy by integrating metal-free photoinduced electron transfer-atom transfer radical polymerization (PET-ATRP) with the bio-inspired polydopamine (PDA) chemistry for controlled architecture of functional polymer brushes from MNPs. Conformal PDA encapsulation layers were initially generated on the surfaces of MNPs, which served as the protective shells while providing an ideal platform for tethering 2-bromo-2-phenylacetic acid (BPA), a highly efficient initiator...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345095/a-simple-functional-carbon-nanotube-fiber-for-in-vivo-monitoring-of-no-in-a-rat-brain-following-cerebral-ischemia
#9
Li Liu, Limin Zhang, Zhihui Dai, Yang Tian
Nitric oxide (NO) is key free-radical messenger and neuronal signal which is closely related to many brain diseases. It is a challenge to develop a sensitive and reliable biosensor for in vivo monitoring of NO in the brain. In this research, a simple ratiometric electrochemical biosensor for NO monitoring in rat brain following cerebral ischemia was developed using a carbon nanotube fiber (CNF) modified with hemin, in which the CNF not only served as a platform to assemble the hemin molecule, but greatly facilitated the electron transfer of hemin on to the electrode surface...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28344405/biochemical-components-of-seminal-plasma-and-their-correlation-to-the-fresh-seminal-characteristics-in-marwari-stallions-and-poitou-jacks
#10
Thirumala Rao Talluri, Gorakh Mal, Sanjay Kumar Ravi
AIM: To investigate various biochemical components of seminal plasma in Marwari stallions and Poitou Jacks and to find out their correlation with that of the seminal characteristics. MATERIALS AND METHODS: In this study, semen was collected from six Marwari stallions and six Poitou jacks aged from 4 to 6 years and with known fertility status. The semen collection from the stallions were collected during the breeding season, i.e., between the months of April and June...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28343034/bioactivities-of-achillea-phrygia-and-bupleurum-croceum-based-on-the-composition-of-phenolic-compounds-in%C3%A2-vitro-and-in-silico-approaches
#11
Gokhan Zengin, Gizem Bulut, Adriano Mollica, Mehmet Zeki Haznedaroglu, Ahmet Dogan, Abdurrahman Aktumsek
This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating...
March 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28342966/time-courses-of-post-injury-mitochondrial-oxidative-damage-and-respiratory-dysfunction-and-neuronal-cytoskeletal-degradation-in-a-rat-model-of-focal-traumatic-brain-injury
#12
Rachel L Hill, Indrapal N Singh, Juan A Wang, Edward D Hall
Traumatic brain injury (TBI) results in rapid reactive oxygen species (ROS) production and oxidative damage to essential brain cellular components leading to neuronal dysfunction and cell death. It is increasingly appreciated that a major player in TBI-induced oxidative damage is the reactive nitrogen species (RNS) peroxynitrite (PN) which is produced in large part in injured brain mitochondria. Once formed, PN decomposes into highly reactive free radicals that trigger membrane lipid peroxidation (LP) of polyunsaturated fatty acids (e...
March 23, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28342757/role-of-enzymatic-free-radical-scavengers-in-management-of-oxidative-stress-and-autoimmune-disorders
#13
REVIEW
Shikha Srivastava, Deependra Singh, Satish Patel, Manju R Singh
Autoimmune disorders are distinct with over production and accumulation of free radicals due to its undisclosed genesis. The cause of numerous disorders as cancer, arthritis, psoriasis, diabetes, alzheimer's, cardiovascular disease, Parkinson's, respiratory distress syndrome, colitis, crohn's, pulmonary fibrosis, obesity and ageing have been associated with immune dysfunction and oxidative stress. In an oxidative stress, reactive oxygen species generally provoke the series of oxidation at cellular level. The buildup of free radicals in turn triggers various inflammatory cells causing release of various inflammatory interleukins, cytokines, chemokines, and tumor necrosis factors which mediate signal transduction and transcription pathways as nuclear factor- kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1 (HIF-1α) and nuclear factor-erythroid 2-related factor (Nrf2)...
March 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28342660/caveolin-1-as-prognostic-factor-of-disease-recurrence-and-survival-in-patients-treated-with-radical-cystectomy-for-bladder-cancer
#14
Francesco Soria, Ilaria Lucca, Marco Moschini, Romain Mathieu, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Michael Rink, Kilian M Gust, Melanie R Hassler, Beat Foerster, Mohammad Abufarraj, Andrea Haitel, Tobias Klatte, Shahrokh F Shariat
PURPOSE: Overexpression of Caveolin-1 has been associated with cancer growth, migration, and metastases in several malignancies, but only few data are available on its role in bladder cancer (BCa). The aim of this study is to validate Caveolin-1 as a prognosticator of recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) in a large cohort of patients treated with radical cystectomy (RC) for BCa. METHODS: Caveolin-1 expression was evaluated by immunochemistry on a tissue microarray from 424 patients treated with RC for UCB at a single institution...
March 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28342352/mechanochemical-mechanism-of-rapid-dechlorination-of-hexachlorobenzene
#15
Shanshan Deng, Shaoguo Kang, Nannan Feng, Jianxin Zhu, Bo Yu, Xiaofeng Xie, Jing Chen
Recent researches indicate that mechanochemical treatment (MCT) is a promising method to degrade the environmental hazards, especially in the area of persistent organic pollutants (POPs) disposal. However, the mechanochemical dechlorination mechanism of POPs still needs to be further verified. In this mechanochemical process, hexachlorobenzene (HCB) was chosen as a model pollutant with aluminum and alumina (Al+Al2O3) powders as the co-milling regents. Both of the intermediate analysis and quantum chemical calculations were adopted to elucidate the free radical dechlorination mechanism of HCB...
March 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28341974/free-radical-and-superoxide-reactivity-detection-in-semen-quality-assessment-past-present-and-future
#16
REVIEW
Jaime Gosalvez, Eva Tvrda, Ashok Agarwal
Oxidative stress is a well-established cause of male infertility, with reactive oxygen species (ROS) impairing sperm production, motility, membrane, and DNA integrity. Currently, most clinics do not test infertile patients for the imbalance between ROS generation and the ability of the antioxidants to scavenge them, although there is a clear need for andrology laboratories to be able to identify and/or quantify seminal oxidative stress. As such there is a clinical urgency for an inexpensive and easy-to-perform assay able to identify oxidative stress in semen...
March 25, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28341613/radical-scavenging-activity-of-a-sunscreen-enriched-by-antioxidants-providing-protection-in-the-whole-solar-spectral-range
#17
Carla Souza, Patrícia Maia Campos, Sabine Schanzer, Stephanie Albrecht, Silke B Lohan, Juergen Lademann, Maxim E Darvin, Martina C Meinke
The literature claims that incorporation of antioxidants into sunscreens provides additional skin photoprotection by scavenging free radicals formed due to sun radiation, but there are limited in vivo studies that support this hypothesis. This study aims to examine whether addition of antioxidants to a broad-spectrum sunscreen increases its photoprotective effect in real-use conditions. Sunscreen formulations composed of stable UV filters (Tinosorb® S, Tinosorb® M, Uvinul® APlus, and Uvinul® T150) alone or in combination with antioxidants (Spirulina and dimethylmethoxy chromanol-loaded solid lipid nanoparticles) were developed and their appearance, odor, rheological behavior, Sun Protection Factor (SPF), and UVA protection were analyzed...
March 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28341088/the-latest-treatment-strategy-for-the-rheumatoid-hand-deformity
#18
Hajime Ishikawa
With a remarkable improvement in the pharmacotherapy of rheumatoid arthritis (RA), severely handicapped patients are very rare to see. Healing, repair and drug-free, and toward radical cure are coming to be possible. In the clinical practice, more than 50% of the patients are in remission. However, some patients are still difficult to reach remission due to comorbidities and economic burden. In the patient with clinical remission, smoldering synovitis so called "silent destructor" is often detected by ultrasonograpy or by synovial histology in the small joints of the hand...
March 22, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28340409/mitochondrial-dna-damage-and-oxidative-damage-in-hl-60-cells-exposed-to-900mhz-radiofrequency-fields
#19
Yulong Sun, Lin Zong, Zhen Gao, Shunxing Zhu, Jian Tong, Yi Cao
HL-60 cells, derived from human promyelocytic leukemia, were exposed to continuous wave 900MHz radiofrequency fields (RF) at 120μW/cm(2) power intensity for 4h/day for 5 consecutive days to examine whether such exposure is capable damaging the mitochondrial DNA (mtDNA) mediated through the production of reactive oxygen species (ROS). In addition, the effect of RF exposure was examined on 8-hydroxy-2'-dexoyguanosine (8-OHdG) which is a biomarker for oxidative damage and on the mitochondrial synthesis of adenosine triphosphate (ATP) which is the energy required for cellular functions...
March 7, 2017: Mutation Research
https://www.readbyqxmd.com/read/28340109/mth1-an-8-oxo-2-deoxyguanosine-triphosphatase-and-myh-a-dna-glycosylase-cooperate-to-inhibit-mutations-induced-by-chronic-exposure-to-oxidative-stress-of-ionising-radiation
#20
Sara Shakeri Manesh, Traimate Sangsuwan, Ali Pour Khavari, Asal Fotouhi, S Noushin Emami, Siamak Haghdoost
Our previous results showed that in addition to the immediate interaction of ionising radiation with DNA (direct and indirect effect), low-dose and chronic low-dose rate of irradiation induce endogenous oxidative stress. During oxidative stress, free radicals react with DNA, nucleoside triphosphates (dNTPs), proteins and lipids, and modify their structures. The MYH and MTH1 genes play important roles in preventing mutations induced by 8-hydroxy-guanine, which is an oxidised product of guanine. In this study, we used short-hairpin RNA to permanently knockdown MYH and MTH1 proteins in human lymphoblastoid TK6 cells...
March 16, 2017: Mutagenesis
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