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https://www.readbyqxmd.com/read/29786865/infection-with-phytopathogenic-bacterium-inhibits-melatonin-biosynthesis-decreases-longevity-of-its-vector-and-suppresses-the-free-radical-defense
#1
Yasser Nehela, Nabil Killiny
Vector-borne phytopathogenic bacteria may alter the reproductive fitness, survival, behavior, and metabolism of their vectors. Candidatus Liberibacter asiaticus (CLas) is associated with the Huanglongbing (HLB; also known as citrus greening disease), one of the most destructive citrus diseases worldwide, and transmitted by Asian citrus psyllid, Diaphorina citri (Insecta, Hemiptera, Liviidae). The genome sequencing of CLas revealed that it does not have the ability to synthesize tryptophan, the precursor of melatonin, and it must acquire it from its host plant or insect vector to achieve its biological processes, such as growth and multiplication...
May 22, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29786720/a-strain-induced-subwavelength-structure-for-a-haze-free-and-highly-transparent-flexible-plastic-substrate
#2
Jae Yong Park, Juyoung Ham, Illhwan Lee, Jong-Lam Lee
This paper presents a method to produce subwavelength-scale (<250 nm) AgCl nanostructures on a flexible plastic film, which is indispensable for highly efficient flexible displays. Using Cl2 plasma treatment on an Ag-coated plastic film, AgCl nanostructures were produced through the reaction of Ag atoms with Cl radicals. During the reaction, the volume of AgCl expands, leading to drastically changed surface morphology from a two-dimensional (2D) flat Ag surface to a 3D subwavelength-scale AgCl nanostructure...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786578/-influence-of-basic-dental-materials-on-indicators-of-free-radical-oxidation-and-antioxidant-blood-s-potential-of-white-rats-experimental-study
#3
Vitalii S Kuz, Valentyn N Dvornyk, Vitalii A Kostenko, Gelfira M Kuz, Oleh Ye Akimov
OBJECTIVE: Introduction: Basic materials used in the clinic of orthopedic dentistry are high-polymer compounds and have a number of positive properties in certain conditions. The main group of materials for manufacturing of removable dentures is acrylic plastics of hot polymerization. However, such materials can sometimes cause a number of complications. Using removable prostheses, which are made of acrylic plastics can cause the development of an allergic or toxic-chemical reaction of tissues of the prosthetic bed...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786561/impedance-based-cellular-assays-for-regenerative-medicine
#4
REVIEW
W Gamal, H Wu, I Underwood, J Jia, S Smith, P O Bagnaninchi
Therapies based on regenerative techniques have the potential to radically improve healthcare in the coming years. As a result, there is an emerging need for non-destructive and label-free technologies to assess the quality of engineered tissues and cell-based products prior to their use in the clinic. In parallel, the emerging regenerative medicine industry that aims to produce stem cells and their progeny on a large scale will benefit from moving away from existing destructive biochemical assays towards data-driven automation and control at the industrial scale...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786128/long-term-oncologic-outcomes-of-laparoscopic-sentinel-node-navigation-surgery-in-early-gastric-cancer-a-single-center-single-arm-phase-ii-trial
#5
Do Joong Park, Young Suk Park, Sang Yong Son, Ju-Hee Lee, Hye Seung Lee, Young Soo Park, Kyoung Ho Lee, Young Hoon Kim, Kyoung Un Park, Won Woo Lee, Soyeon Ahn, Sang-Hoon Ahn, Hyung-Ho Kim
BACKGROUND: Sentinel node navigation surgery (SNNS) in early gastric cancer (EGC) is technically feasible according to previous literature, however its long-term oncologic safety has not been reported. METHODS: A single-center, single-arm, phase II trial was conducted to determine the oncologic outcomes of laparoscopic sentinel node (SN) biopsy in clinical stage T1N0M0 gastric cancer patients. Cases with positive SNs on intraoperative pathologic examination underwent conventional gastrectomy with radical lymphadenectomy (SN-positive group), whereas those with negative SNs underwent laparoendoscopic-limited gastric resections without further lymph node dissections (SN-negative group)...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29785849/dietary-carotenoid-roles-in-redox-homeostasis-and-human-health
#6
Marcelo Paes Barros, Maria J Rodrigo, Lorenzo Zacarias
Classic nutrition believed that healthy diets should simply provide sufficient antioxidant loads to organisms, to hamper free radical processes and avoid oxidative stress. Current redox biology was proven much more intricate. Carotenoids are bioactive compounds in human diet with a multifaceted role in redox metabolism. This review discusses the participation of α/β-carotene, lutein, zeaxanthin, lycopene, β-cryptoxanthin, astaxanthin, and derivatives in redox homeostasis focusing on: (i) their anti-/pro-oxidant activities; (ii) control of gene expression via Nrf2-Keap1 and NF-ΚB pathways; and (iii) their link with (sub)cellular redox circuits, as part of the 'redox code' that orchestrates physiological processes and health in humans...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29785426/theoretical-insights-into-the-reactivity-of-fe-based-catalysts-for-water-oxidation-the-role-of-electron-withdrawing-groups
#7
Penglin Xu, Shaojin Hu, Hou-Dao Zhang, Xiao Zheng
Recent experiments have shown that complex (1), [Fe(OTf)2(Pytacn)] (OTf = CF3SO3-, Pytacn = 1-(2'-pyridylmethyl)-4,7-dimethyl-1,4,7-triazacyclononane), is a promising artificial photosynthetic catalyst because of its distinct capability in water oxidation. Experimentalists have also synthesized several derivatives, e.g., [Fe(OTf)2(E,HPytacn)] (E = -Cl (2), -CO2Et (3) and -NO2 (4)) and [Fe(OTf)2 (E,RPytacn)] (R = -F (5) and R = -Me (6)), and proposed that the E-substituted electron-withdrawing groups could improve the catalytic efficiency...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29785299/thoracoscopic-segmentectomy-hybrid-approach-for-clinical-stage-i-non-small-cell-lung-cancer
#8
Koyo Shirahashi, Hirotaka Yamamoto, Mitsuyoshi Matsumoto, Yusaku Miyamaoto, Hiroyasu Komuro, Kiyoshi Doi, Hisashi Iwata
Background: Recently, minimally invasive surgical approaches have been developed, typified by video-assisted thoracic surgery (VATS). A meticulous surgical procedure to prevent local recurrence is required during segmentectomy for clinical stage I non-small-cell primary lung cancer. In this article, we demonstrated the validity of hybrid VATS segmentectomy. Methods: Of these 125 patients, 62 (49.6%) underwent intensively radical segmentectomy (RS). The remaining 63 (50...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29785158/obtaining-adequate-surgical-margin-status-in-breast-conservation-therapy-intraoperative-ultrasound-guided-resection-versus-specimen-mammography
#9
Maria Mihaela Pop, Silviu Cristian, Orsolya Hanko-Bauer, Dana Valentina Ghiga, Rares Georgescu
Background and aim: The purpose of breast-conserving surgery (BCS) for women with cancer is to perform an oncological radical procedure with disease-free margins at the final histological assessment and with the best aesthetic result possible. Intraoperative resected specimen ultrasound and intraoperative resected specimen mammography may reduce the rates of positive margins and reexcision among patients undergoing conserving therapy. Our objective is to compare the two methods with the histopathological results for a preset cut off and asses which parameters can influence the positive margin status...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29785080/prognostic-impact-of-the-red-cell-distribution-width-in-esophageal-cancer-patients-a-systematic-review-and-meta-analysis
#10
Wei-Yu Xu, Xiao-Bo Yang, Wen-Qin Wang, Yi Bai, Jun-Yu Long, Jian-Zhen Lin, Jian-Ping Xiong, Yong-Chang Zheng, Xiao-Dong He, Hai-Tao Zhao, Xin-Ting Sang
AIM: To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width (RDW) in esophageal cancer (EC). METHODS: We searched the PubMed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible: (1) Studies including EC patients who underwent radical esophagectomy; (2) studies including patients with localized disease without distant metastasis; (3) studies including patients without preoperative neoadjuvant therapy; (4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes; (5) studies reporting association between the preoperative RDW and overall survival (OS)/disease-free survival (DFS)/cancer-specific survival (CSS); and (6) studies published in English...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29784368/an-ultrasensitive-electrochemiluminescence-immunosensor-based-on-platinum-nickel-nanocubes-l-cysteine-luminol-nanocomposite
#11
Yinfang Wang, Haifeng Sha, Hong Ke, Nengqin Jia
An ultrasensitive electrochemiluminescence (ECL) immunosensor was initially developed for quantitative detection of carbohydrate antigen 15-3 (CA15-3) using platinum nickel nanocubes-L-cysteine-luminol nanocomposite (PtNi NCs-L-Cys-luminol) as signal probe. Herein, the PtNi NCs-L-Cys-luminol nanocomposite was modified on the glassy carbon electrode (GCE) surface via the film-forming properties of chitosan. Then, the CA15-3 antibody was attached to the modified electrode surface by amidating reaction to construct the ECL immunosensor...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784362/programmable-electrochemical-flow-system-for-high-throughput-determination-of-total-antioxidant-capacity
#12
Kornautchaya Veenuttranon, Loc Thai Nguyen
The aim of this work was to develop a programmable flow system for rapid assessment of total antioxidant capacity (TAC). Novel features of the prototype include a single pressure-driven source, versatile manipulation of fluid flows, ability to adapt to different TAC assays, and compatibility with microfluidic design. Antioxidant activity was determined by electrochemical measurement of residual 2,2-diphenyl-2-picrylhydrayl hydrate (DPPH•) free radicals in the solution. The overall performance of the device was validated by the spectrophotometric method...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784190/randomized-trial-comparing-open-radical-cystectomy-and-robot-assisted-laparoscopic-radical-cystectomy-oncologic-outcomes
#13
Bernard H Bochner, Guido Dalbagni, Karim H Marzouk, Daniel D Sjoberg, Justin Lee, Sheri M Donat, Jonathan A Coleman, Andrew Vickers, Harry W Herr, Vincent P Laudone
BACKGROUND: Open radical cystectomy (ORC) has proven to be an important component in the treatment of high-risk bladder cancer (BCa). ORC surgical morbidity remains high; therefore, minimally invasive surgical techniques have been introduced in an attempt to improve patient outcomes. OBJECTIVE: To compare cancer outcomes in BCa patients managed with ORC or robotic-assisted radical cystectomy (RARC). DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized trial was completed between 2010 and 2013...
May 18, 2018: European Urology
https://www.readbyqxmd.com/read/29784042/neoadjuvant-oxaliplatin-and-capecitabine-combined-with-bevacizumab-plus-radiotherapy-for-locally-advanced-rectal-cancer-results-of-a-single-institute-phase-ii-study
#14
Xin Yu, Qiao-Xuan Wang, Wei-Wei Xiao, Hui Chang, Zhi-Fan Zeng, Zhen-Hai Lu, Xiao-Jun Wu, Gong Chen, Zhi-Zhong Pan, De-Sen Wan, Pei-Rong Ding, Yuan-Hong Gao
BACKGROUND: Neoadjuvant chemoradiotherapy followed by surgery is recommended as the standard of care for locally advanced rectal cancer, reducing local recurrence but not distant metastasis. Intensified systemic therapy is warranted to reduce the risk of distant metastasis. The present study aimed to evaluate the safety and efficacy of neoadjuvant oxaliplatin and capecitabine (XELOX) combined with bevacizumab plus radiotherapy for locally advanced rectal cancer. METHODS: Patients with stages II to III rectal cancer received one cycle of induction chemotherapy and concurrent chemoradiotherapy with XELOX plus bevacizumab...
May 21, 2018: Cancer communications
https://www.readbyqxmd.com/read/29783628/is-3-carboxy-4-methyl-5-propyl-2-furanpropionate-cmpf-a-clinically-relevant-uremic-toxin-in-haemodialysis-patients
#15
Mathilde Luce, Anais Bouchara, Myriam Pastural, Samuel Granjon, Jean Christophe Szelag, Maurice Laville, Walid Arkouche, Denis Fouque, Christophe O Soulage, Laetitia Koppe
3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) is a metabolite of furan fatty acid and a marker of fish oil intake. CMPF is described as a protein-bound uremic toxin and interacts with free oxygen radicals, which can induce cell damages. However, the clinical consequences of CMPF accumulation in haemodialysis patients remain poorly documented. The aims of this study are to investigate potential association between CMPF levels and (i) biochemical and nutritional parameters; (ii) cardiovascular events and (iii) mortality...
May 18, 2018: Toxins
https://www.readbyqxmd.com/read/29783141/graphene-oxide-and-carbon-nanodots-co-modified-biobr-nanocomposites-with-enhanced-photocatalytic-4-chlorophenol-degradation-and-mechanism-insight
#16
Songying Qu, Yuhan Xiong, Jun Zhang
Non-metallic graphene oxide (GO) and carbon nanodots (CDots) co-doped BiOBr ternary system (GO/CDots/BiOBr) were successfully synthesized via a simple one-step solvothermal process. The compositional characterization, optical and electrical properties of photocatalysts were investigated in detail. The prepared ternary photocatalysts possessed the excellent visible-light driven photocatalytic 4-chlorophenol (4-CP) degradation. Additionally, the 4-CP removal efficiencies decreased in the order of GO/CDots/BiOBr (88...
May 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29782675/hierarchical-micro-nanostructures-from-human-hair-for-biomedical-applications
#17
Di-Wei Zheng, Sheng Hong, Lu Xu, Chu-Xin Li, Ke Li, Si-Xue Cheng, Xian-Zheng Zhang
With the prominent progress of biomedical engineering, materials with high biocompatibility and versatile functions are urgently needed. So far, hierarchical structures in nature have shed some light on the design of high performance materials both in concept and implementation. Inspired by these, the hierarchical micro-/nanostructures of human hair are explored and human hair is further broken into hierarchical microparticles (HMP) and hierarchical nanoparticles (HNP) with top-down procedures. Compared with commercialized carriers, such as liposomes or albumin nanoparticles, the obtained particles exhibit high hemocompatibility and negligible immunogenicity...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29781752/streptozotocin-induced-diabetes-in-rats-effects-of-white-butterfly-clerodendrum-volubile-leaves-on-blood-glucose-levels-lipid-profile-and-antioxidant-status
#18
Olorunfemi R Molehin, Omotade I Oloyede, Stephen A Adefegha
White Butterfly (Clerodendrum volubile) leaf is commonly used in traditional medicine for the management of various diseases including diabetes without the full understanding of the scientific basis for its use. This study sought to evaluate the antihyperglycemic, antihyperlipidemic and antioxidant effect of Clerodendrum volubile leaves in streptozotocin (STZ)-induced diabetic rats. Aqueous extract of C. volubile was prepared and its effect assessed on relevant enzymes associated with diabetes. Fifty Male Wistar rats were randomly separated into ten groups each containing five rats...
May 21, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29781567/localized-vaginal-uterine-rhabdomyosarcoma-results-of-a-pooled-analysis-from-four-international-cooperative-groups
#19
Veronique Minard-Colin, David Walterhouse, Gianni Bisogno, Helene Martelli, James Anderson, David A Rodeberg, Andrea Ferrari, Meriel Jenney, Suzanne Wolden, Gianluca De Salvo, Carola Arndt, Johannes H M Merks, Soledad Gallego, Dominique Schwob, Christine Haie-Meder, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Douglas Hawkins
BACKGROUND: Vaginal/uterine rhabdomyosarcoma (VU RMS) is one of the most favorable RMS sites. To determine the optimal therapy, the experience of four cooperative groups (Children's Oncology Group [COG], International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Group [MMT], Italian Cooperative Soft Tissue Sarcoma Group [ICG], and European pediatric Soft tissue sarcoma Study Group [EpSSG]) was analyzed. PROCEDURE: From 1981 to 2009, 237 patients were identified...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29781273/visible-light-driven-decarboxylative-alkylation-of-c-h-bond-catalyzed-by-dye-sensitized-semiconductor
#20
Li Ren, Huan Cong
A decarboxylative alkylation of benzylic C(sp3 )-H bonds of N-aryl tetrahydroisoquinolines under the irradiation of blue light is reported, featuring a broad substrate scope, low cost, heavy-metal-free, and mild conditions. A preliminary mechanistic study indicated that radical intermediates are involved during the course of the reaction.
May 21, 2018: Organic Letters
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