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https://www.readbyqxmd.com/read/29350786/multiple-biological-defects-caused-by-calycosin-7-o-%C3%AE-d-glucoside-in-the-nematode-caenorhabditis-elegans-are-associated-with-the-activation-of-oxidative-damage
#1
Jianqin Zhang, Xiaoli Xue, Yang Yang, Wen Ma, Yan Han, Xuemei Qin
Calycosin-7-O-β-d-glucoside (CG) is an important active isoflavone compound in Radix Astragali that has many bioactivities. However, the toxicological effects and related toxicological mechanism of CG have been rarely documented. The purpose of the present study was to evaluate the toxicity effects of CG on the model organism Caenorhabditis elegans. Some characteristics of the nematode, including lifespan, movement behavior and reproductive capacity, were used to detect the toxic effects of CG on C. elegans...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29350733/a-catalyst-free-intermolecular-trans-iodoalkylation-of-alkynes
#2
Jie-Jie Liu, Hong-Yan Huang, Liang Cheng, Qi Liu, Dong Wang, Li Liu
We report the first catalyst-free and trans-selective iodoalkylation reaction of alkynes with a series of α-carbonyl compounds. This unprecedented three-component iodoalkylation reaction is enabled by using (iodoethynyl)trimethylsilane as a radical initiator and iodide source. The 1,2-difunctionalization affords alkenyl iodides, which are versatile building blocks for the construction of tri-substituted alkene derivatives.
January 19, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29350528/proton-and-carbon-13-dynamic-nuclear-polarization-of-methylated-%C3%AE-cyclodextrins
#3
Filippo Caracciolo, Alessandra Lucini Paioni, Lucio Melone, Marta Filibian, Pietro Carretta
1 H and 13 C dynamic nuclear polarization has been studied in 13 C-enriched β - cyclodextrins doped with TEMPO free radical. 1 H and 13 C polarizations raised above 7.5 % and 7 % , respectively, and for both nuclear species the transfer of polarization from the electron spins appears to be consistent with a thermal mixing scenario for a concentration of 9 13 C nuclei per molecule. When the concentration is increased to 21 13 C nuclei per molecule a decrease in the spin-lattice relaxation and polarization build up rates is observed...
January 19, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29350310/proanthocyanidins-and-the-risk-of-prostate-cancer-in-italy
#4
Delphine Praud, Maria Parpinel, Valentina Guercio, Cristina Bosetti, Diego Serraino, Gaetano Facchini, Maurizio Montella, Carlo La Vecchia, Marta Rossi
Proanthocyanidins are polymers of monomeric unit flavan-3-ols with antioxidant, anti-inflammatory and free radical scavenging activities. We investigated the association between proanthocyanidin intake and prostate cancer risk through data that were collected between 1991 and 2002 in an Italian case-control study, including a total of 1,294 incident, histologically confirmed cases of prostate cancer and 1,451 controls admitted to hospital for acute, non-neoplastic, and non-hormone-related diseases. We estimated odds ratios (ORs) and their 95% confidence intervals (CIs) using multiple logistic regression models, and computed energy-adjusted proanthocyanidin intakes using the residual method...
January 19, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29350299/mutagenicity-cytotoxic-and-antioxidant-activities-of-ricinus-communis-different-parts
#5
Mazhar Abbas, Abid Ali, Muhammad Arshad, Asia Atta, Zahed Mehmood, Imtiaz Mahmood Tahir, Munawar Iqbal
Ricinus communis (castor plant) is a potent medicinal plant, which is commonly used in the treatment of various ailments. The present study was conducted to appraise the cytotoxicity and mutagenicity of R. communis along with antioxidant and antimicrobial activities. Cytotoxicity was evaluated by hemolytic and brine shrimp assays, whereas Ames test (TA98 and TA100) was used for mutagenicity evaluation. Plant different parts were extracted in methanol by shaking, sonication and Soxhlet extraction methods. The R...
January 19, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29349663/ibandronate-metal-complexes-solution-behavior-and-antiparasitic-activity
#6
Bruno Demoro, Santiago Rostán, Mauricio Moncada, Zhu-Hong Li, Roberto Docampo, Claudio Olea Azar, Juan Diego Maya, Julia Torres, Dinorah Gambino, Lucía Otero
To face the high costs of developing new drugs, researchers in both industry and academy are looking for ways to repurpose old drugs for new uses. In this sense, bisphosphonates that are clinically used for bone diseases have been studied as agents against Trypanosoma cruzi, causative parasite of Chagas disease. In this work, the development of first row transition metal complexes (M = Co2+, Mn2+, Ni2+) with the bisphosphonate ibandronate (iba, H4iba representing the neutral form) is presented. The in-solution behavior of the systems containing iba and the selected 3d metal ions was studied by potentiometry...
January 18, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29349512/photobiomodulation-induces-in-vitro-re-epithelialization-via-nitric-oxide-production
#7
Manuela Rizzi, Mario Migliario, Stelvio Tonello, Vincenzo Rocchetti, Filippo Renò
Photobiomodulation is a widely used tool in regenerative medicine thanks to its ability to modulate a plethora of physiological responses. Wound re-epithelialization is strictly regulated by locally produced chemical mediators, such as nitric oxide (NO), a highly reactive free radical generated by the nitric oxide synthase (NOS) enzymatic family. In this study, it has been hypothesized that a 980-nm low-level laser stimulation could increase NO production in human keratinocytes and that such event might be directly related to the re-epithelialization process...
January 18, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29346581/melatonin-attenuates-lung-ischaemia-reperfusion-injury-via-inhibition-of-oxidative-stress-and-inflammation
#8
Ming-Liang Wang, Chun-Hua Wei, Wen-Dong Wang, Jia-Shun Wang, Jun Zhang, Jian-Jun Wang
OBJECTIVES: Lung ischaemia-reperfusion injury is a complex pathophysiological process due to the production of reactive oxygen species and the generation of inflammatory reaction. We investigated the protective effects and the corresponding mechanism of melatonin (MT), a potent free-radical scavenger, on lung injury induced by ischaemia-reperfusion in a mouse model. METHODS: Adult male C57BL/6J mice (n = 30) were randomly and equally allocated into 5 groups: sham controls, IR, IR + 10 mg/kg MT, IR + 20 mg/kg MT and IR + 30 mg/kg MT...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29345453/poly-glycidol-coating-on-ultrahigh-molecular-weight-polyethylene-for-reduced-biofilm-growth
#9
Jacob N Lockhart, Thomas J Spoonmore, Michael W McCurdy, Bridget R Rogers, Scott A Guelcher, Eva Harth
Semibranched poly(glycidol) (PG-OH) and poly(glycidol allylglycidyl ether) (PG-Allyl) coatings were formed on ultrahigh molecular weight polyethylene (UMWPE) in a unique two-step process which included radiation of UHMWPE followed by grafting of PG-OH or PG-Allyl to the surface via free radical cross-linking. Resulting surfaces were extensively characterized by FTIR-ATR, XPS, fluorescent microscopy, and contact goniometry. The performance was evaluated using the most prominent biofilm-forming bacteria Staphylococcus aureus for 24 and 48 h...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29344826/phytochemical-analysis-and-evaluation-of-the-antioxidant-anti-inflammatory-and-antinociceptive-potential-of-phlorotannin-rich-fractions-from-three-mediterranean-brown-seaweeds
#10
Amal Abdelhamid, Meriem Jouini, Haifa Bel Haj Amor, Zeineb Mzoughi, Mehdi Dridi, Rafik Ben Said, Abderrahman Bouraoui
Phlorotannins, phenolic compounds produced exclusively by seaweeds, have been reported to possess various pharmacological properties. However, there have been few works on these compounds from Mediterranean seaweeds. In this study, we investigated the phytochemical analysis and pharmacological potential of phlorotannin-rich fractions from three brown seaweeds collected along the Tunisia coast: Cystoseira sedoides (PHT-SED), Cladostephus spongeosis (PHT-CLAD), and Padina pavonica (PHT-PAD). Phytochemical determinations showed considerable differences in total phenolic content (TPC) and phlorotannin content (PHT)...
January 18, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29344201/elevation-of-serum-cea-and-ca15-3-levels-during-antitumor-therapy-predicts-poor-therapeutic-response-in-advanced-breast-cancer-patients
#11
Yue Yang, Huijuan Zhang, Mingyan Zhang, Qingwei Meng, Li Cai, Qingyuan Zhang
The aim of the present study was to assess the correlation between therapeutic response and carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) levels in advanced breast cancer patients with non-assessable lesions or stable disease (SD) according to the Response Evaluation Criteria in Solid Tumors. A total of 232 female patients with recurrent tumors following radical mastectomy were recruited, including 76 patients with non-assessable lesions and 60 patients with SD. The correlation between CEA and CA15-3 changes, progression-free survival (PFS) and therapeutic response were analyzed in the non-assessable and SD patient groups...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344163/clinical-characteristics-and-treatment-outcomes-of-parathyroid-carcinoma-a-retrospective-review-of-234-cases
#12
Peisong Wang, Shuai Xue, Shuo Wang, Zhi Lv, Xianying Meng, Guimin Wang, Wei Meng, Jia Liu, Guang Chen
Parathyroid carcinoma (PC) is one of the rarest known types of cancer and has a moderate prognosis, with estimated 5- and 10-year overall survival rates between 78-85% and between 49-70%, respectively. To raise awareness of this disease, and to optimize its diagnosis, clinical management and prognosis, the present study retrospectively reviewed 234 cases of PC. A total of 226 cases of PC, which were archived between 1984 and 2015 in the three major databases of the Chinese population, were retrieved and pooled with the 8 cases diagnosed and treated at the Department of Thyroid Surgery of The First Hospital of Jilin University (Changchun, China) between June 2008 and December 2015...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29342060/creep-and-wear-in-vitamin-e-infused-highly-cross-linked-polyethylene-cups-for-total-hip-arthroplasty-a-prospective-randomized-controlled-trial
#13
G Rochcongar, G Buia, E Bourroux, J Dunet, V Chapus, C Hulet
BACKGROUND: Aseptic loosening, the most common indication for revision surgery in total hip arthroplasty, can result from osteolysis caused by polyethylene (PE) wear particles. PE wear is increased by age-related oxidation of PE and free radicals emerging during irradiation cross-linking. Diffusion of vitamin E into PE stabilizes free radicals to maintain the biomechanical properties of PE. The purpose of this study was to determine whether vitamin E-infused highly cross-linked PE cups could reduce wear rates...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341860/risk-management-of-free-radicals-involved-in-air-travel-syndromes-by-antioxidants
#14
Jeum-Nam Kim, Byung-Mu Lee
Frequent air travelers and airplane pilots may develop various types of illnesses. The environmental risk factors associated with air travel syndromes (ATS) or air travel-related adverse health outcomes raised concerns and need to be assessed in the context of risk management and public health. Accordingly, the aim of the present review was to determine ATS, risk factors, and mechanisms underlying ATS using scientific data and information obtained from Medline, Toxline, and regulatory agencies. Additional information was also extracted from websites of organizations, such as the International Air Transport Association (IATA), International Association for Medical Assistance to Travelers (IAMAT), and International Civil Aviation Organization (ICAO)...
January 17, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29341028/ameliorative-effects-of-zataria-multiflora-hydro-alcoholic-extract-on-gentamicin-induced-nephrotoxicity-in-rats
#15
Saeed Hajihashemi, Tahereh Jafarian, Mahboubeh Ahmadi, Ali Rahbari, Fatemeh Ghanbari
BACKGROUND: Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim of this study was to investigate the therapeutic effects of Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity. METHODS: Twenty-eight male Wistar rats categorized into four groups: 1) the control group without injection, 2) the gentamicin treated group (100 mg/kg, i.p) 3) the gentamicin and Z. Multiflora treated group; Z. Multiflora extract(0...
January 16, 2018: Drug Research
https://www.readbyqxmd.com/read/29340859/comparative-proteomics-of-chromium-transformed-beas-2b-cells-by-2d-dige-and-maldi-tof-tof-ms
#16
Jian Lu, Miaomiao Tang, Yi Liu, Jin Wang, Zhanao Wu
Chromium (Cr) is a highly toxic, common heavy metal used in industrial production. There are two types of Cr in nature: hexavalent chromium (Cr(VI)) and chromium trichloride (Cr(III)). Cr(III) is involved in the metabolism of sugars and lipids, whereas Cr(VI) is absorbed through the respiratory tract and skin and generates free radicals that result in secondary toxicity. Cr(VI) leads to cancer in the occupational population and is therefore recognized as a human carcinogen by the International Agency for Research on Cancer...
January 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29340384/kinetics-of-the-a-c3h5-o2-reaction-investigated-by-photoionization-using-synchrotron-radiation
#17
D Schleier, P Constantinidis, N Faßheber, I Fischer, G Friedrichs, P Hemberger, E Reusch, B Sztáray, K Voronova
The kinetics of the combustion-relevant reaction of the allyl radical, a-C3H5, with molecular oxygen has been studied in a flow tube reactor at the vacuum ultraviolet (VUV) beamline of the Swiss Light Source storage ring, using the CRF-PEPICO (Combustion Reactions Followed by Photoelectron Photoion Coincidence Spectroscopy) setup. The ability to measure threshold photoelectron spectra enables a background-free detection of reactive species as well as an isomer-specific analysis of reaction products. Allyl was generated by direct photodissociation of allyl iodide at 266 nm and 213 nm and indirectly by the reaction of propene with Cl atoms, which were generated by photolysis from oxalyl chloride at 266 nm...
January 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29338220/the-multiple-role-of-bromide-ion-in-ppcps-degradation-under-uv-chlorine-treatment
#18
Shuangshuang Cheng, Xinran Zhang, Xin Yang, Chii Shang, Weihua Song, Jingyun Fang, Yanheng Pan
This study investigated the role of bromide ions in the degradation of nine pharmaceuticals and personal care products (PPCPs) during the UV/chlorine treatment of simulated drinking water containing 2.5 mgC/L natural organic matter (NOM). The kinetics of contributions from UV irradiation and from oxidation by free chlorine, free bromine, hydroxyl radical and reactive halogen species were evaluated. The observed loss rate constants of PPCPs in the presence of 10 μM bromide were 1.6 to 23 times of those observed in the absence of bromide (except for iopromide and ibuprofen)...
January 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29337918/polyacrylamide-ferrogels-with-magnetite-or-strontium-hexaferrite-next-step-in-the-development-of-soft-biomimetic-matter-for-biosensor-applications
#19
Alexander P Safronov, Ekaterina A Mikhnevich, Zahra Lotfollahi, Felix A Blyakhman, Tatyana F Sklyar, Aitor Larrañaga Varga, Anatoly I Medvedev, Sergio Fernández Armas, Galina V Kurlyandskaya
Magnetic biosensors are an important part of biomedical applications of magnetic materials. As the living tissue is basically a "soft matter." this study addresses the development of ferrogels (FG) with micron sized magnetic particles of magnetite and strontium hexaferrite mimicking the living tissue. The basic composition of the FG comprised the polymeric network of polyacrylamide, synthesized by free radical polymerization of monomeric acrylamide (AAm) in water solution at three levels of concentration (1...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29337770/survival-benefit-of-japanese-extended-lymphadenectomy-for-clinically-node-negative-and-node-positive-colorectal-cancers
#20
Akira Ouchi, Koji Komori, Kenya Kimura, Takashi Kinoshita, Yasuhiro Shimizu, Masato Nagino
BACKGROUND: The impact of extended lymphadenectomy for colorectal cancer is still not sufficiently clear. OBJECTIVE: The aim of the present study was to evaluate the survival benefit of extended lymphadenectomy compared with nonextended lymphadenectomy for clinically node-negative and node-positive colorectal cancers. DESIGN: The present study was a retrospective cohort study that used prospectively collected data and a propensity score matching method...
February 2018: Diseases of the Colon and Rectum
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