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diffusion kurtosis

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https://www.readbyqxmd.com/read/28734955/predicting-the-nodal-status-in-gastric-cancers-the-role-of-apparent-diffusion-coefficient-histogram-characteristic-analysis
#1
Song Liu, Yujuan Zhang, Jie Xia, Ling Chen, Wenxian Guan, Yue Guan, Yun Ge, Jian He, Zhengyang Zhou
PURPOSE: To explore the application of histogram analysis in preoperative T and N staging of gastric cancers, with a focus on characteristic parameters of apparent diffusion coefficient (ADC) maps. MATERIALS AND METHODS: Eighty-seven patients with gastric cancers underwent diffusion weighted magnetic resonance imaging (b=0, 1000s/mm(2)), which generated ADC maps. Whole-volume histogram analysis was performed on ADC maps and 7 characteristic parameters were obtained...
July 19, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28728757/value-of-whole-lesion-apparent-diffusion-coefficient-adc-first-order-statistics-and-texture-features-in-clinical-staging-of-cervical-cancers
#2
Y Guan, W Li, Z Jiang, B Zhang, Y Chen, X Huang, J Zhang, S Liu, J He, Z Zhou, Y Ge
AIM: To explore the value of whole-lesion apparent diffusion coefficient (ADC) first-order statistics and texture features in clinical staging of cervical cancers. MATERIALS AND METHODS: Fifty-six women (mean age, 51 years) with histopathologically confirmed cervical cancers underwent 3 T pelvic magnetic resonance imaging including diffusion-weighted imaging (b=0, 800 s/mm(2)) prospectively. The ADC first-order statistics and texture features derived from the whole volume of cervical cancers were correlated with International Federation of Gynecology and Obstetrics (FIGO) stages (i...
July 18, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28725591/diffusion-weighted-imaging-of-the-prostate-principles-application-and-advances
#3
REVIEW
Martin H Maurer, Johannes T Heverhagen
This review article aims to provide an overview on the principles of diffusion-weighted magnetic resonance imaging (DW-MRI) and its applications in the imaging of the prostate. DW-MRI with regards to different applications for prostate cancer (PCa) detection and characterization, local staging as well as for active surveillance (AS) and tumor recurrence after radical prostatectomy (RP) will be discussed. Furthermore, advances in DW-MRI techniques like diffusion kurtosis imaging (DKI) will be presented.
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28718517/evaluation-of-fitting-models-for-prostate-tissue-characterization-using-extended-range-b-factor-diffusion-weighted-imaging
#4
Fredrik Langkilde, Thiele Kobus, Andriy Fedorov, Ruth Dunne, Clare Tempany, Robert V Mulkern, Stephan E Maier
PURPOSE: To compare the fitting and tissue discrimination performance of biexponential, kurtosis, stretched exponential, and gamma distribution models for high b-factor diffusion-weighted images in prostate cancer. METHODS: Diffusion-weighted images with 15 b-factors ranging from b = 0 to 3500 s/mm(2) were obtained in 62 prostate cancer patients. Pixel-wise signal decay fits for each model were evaluated with the Akaike Information Criterion (AIC). Parameter values for each model were determined within normal prostate and the index lesion...
July 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28712716/differentiation-of-glioma-malignancy-grade-using-diffusion-mri
#5
Ivan I Maximov, Aram S Tonoyan, Igor N Pronin
Modern diffusion MR protocols allow one to acquire the multi-shell diffusion data with high diffusion weightings in a clinically feasible time. In the present work we assessed three diffusion approaches based on diffusion and kurtosis tensor imaging (DTI, DKI), and neurite orientation dispersion and density imaging (NODDI) as possible biomarkers for human brain glioma grade differentiation based on the one diffusion protocol. We used three diffusion weightings (so called b-values) equal to 0, 1000, and 2500s/mm(2) with 60 non-coplanar diffusion directions in the case of non-zero b-values...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28708850/tumor-spatial-heterogeneity-in-myxoid-containing-soft-tissue-using-texture-analysis-of-diffusion-weighted-mri
#6
Hyun Su Kim, Jae-Hun Kim, Young Cheol Yoon, Bong Keun Choe
The objective of this study was to examine the tumor spatial heterogeneity in myxoid-containing soft-tissue tumors (STTs) using texture analysis of diffusion-weighted imaging (DWI). A total of 40 patients with myxoid-containing STTs (23 benign and 17 malignant) were included in this study. The region of interest (ROI) was manually drawn on the apparent diffusion coefficient (ADC) map. For texture analysis, the global (mean, standard deviation, skewness, and kurtosis), regional (intensity variability and size-zone variability), and local features (energy, entropy, correlation, contrast, homogeneity, variance, and maximum probability) were extracted from the ADC map...
2017: PloS One
https://www.readbyqxmd.com/read/28702832/effect-of-perfusion-on-diffusion-kurtosis-imaging-estimates-for-in-vivo-assessment-of-integrated-2016-who-glioma-grades-a%C3%A2-cross-sectional-observational-study
#7
Johann-Martin Hempel, Jens Schittenhelm, Cornelia Brendle, Benjamin Bender, Georg Bier, Marco Skardelly, Ghazaleh Tabatabai, Salvador Castaneda Vega, Ulrike Ernemann, Uwe Klose
PURPOSE: To assess the role of perfusion-related signal decay on diffusion kurtosis imaging (DKI) estimates for in vivo stratification of glioma according to the integrated approach of the 2016 World Health Organization classification of tumors of the central nervous system (2016 CNS WHO). METHODS: In this study 77 patients with histopathologically confirmed glioma were retrospectively assessed between January 2013 and February 2017 in a prospective trial. Mean kurtosis (MK) and mean diffusivity (MD) metrics from DKI were assessed by two physicians blinded to the study from a volume of interest around the entire solid tumor...
July 12, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28689259/differential-diagnosis-of-parkinsonism-by-a-combined-use-of-diffusion-kurtosis-imaging-and-quantitative-susceptibility-mapping
#8
Kenji Ito, Chigumi Ohtsuka, Kunihiro Yoshioka, Hiroyuki Kameda, Suguru Yokosawa, Ryota Sato, Yasuo Terayama, Makoto Sasaki
PURPOSE: We investigated whether diffusion kurtosis imaging (DKI) and quantitative susceptibility mapping (QSM) could detect pathological changes that occur in Parkinson's disease (PD), multiple system atrophy with predominant parkinsonism (MSA-P) or predominant cerebellar ataxia (MSA-C), and progressive supranuclear palsy syndrome (PSPS) and thus be used for differential diagnosis that is often difficult. METHODS: Seventy patients (41 with PD, 6 with MSA-P, 7 with MSA-C, 16 with PSPS) and 20 healthy controls were examined using a 3...
July 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28688982/the-effects-of-striatal-silent-lacunar-infarction-on-the-substantia-nigra-and-movement-disorders-in-parkinson-s-disease-a-follow-up-study
#9
Guohua Zhang, Chengguo Zhang, Yuhu Zhang, Yukai Wang, Kun Nie, Bin Zhang, Haiqun Xie, Jiancong Lu, Lijuan Wang
OBJECTIVE: Striatal silent lacunar infarction (SSLI) is associated with structural changes to the substantia nigra (SN), detectable by diffusion kurtosis imaging (DKI). In this follow-up study, we investigated the effects of SSLI on the SN and movement disorders in patients with Parkinson's disease (PD). METHODS: A total of 60 untreated patients with early-stage PD, divided into control and SSLI groups, were enrolled in this study. All participants underwent conventional MRI and DKI twice; at baseline and after a 1-year period...
June 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28661554/differentiation-of-olfactory-neuroblastomas-from-nasal-squamous-cell-carcinomas-using-mr-diffusion-kurtosis-imaging-and-dynamic-contrast-enhanced-mri
#10
Zebin Xiao, Zuohua Tang, Jinwei Qiang, Wen Qian, Yufeng Zhong, Rong Wang, Jie Wang, Lingjie Wu, Wenlin Tang
PURPOSE: To evaluate the use of magnetic resonance (MR) diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced MR imaging (DCE-MRI) in the differentiation of olfactory neuroblastomas (ONBs) from squamous cell carcinomas (SCCs). MATERIALS AND METHODS: DKI and DCE-MRI were performed in 17 patients with ONBs and 23 patients with SCCs on a 3T MR scanner. Parameters derived from DKI and DCE-MRI were measured and compared between ONBs and SCCs using an independent samples t-test...
June 29, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28659787/better-correlation-of-cognitive-function-to-white-matter-integrity-than-to-blood-supply-in-subjects-with-leukoaraiosis
#11
Genlong Zhong, Ruiting Zhang, Yerfan Jiaerken, Xinfeng Yu, Ying Zhou, Chang Liu, Longting Lin, Lusha Tong, Min Lou
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged from 43 to 85 years, with mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) subjects presented with cerebral microbleeds (CMB) and 40 (53...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28640476/histogram-analyses-of-diffusion-kurtosis-indices-and-apparent-diffusion-coefficient-in-assessing-liver-regeneration-after-alpps-and-a-comparative-study-with-portal-vein-ligation
#12
Ruo-Fan Sheng, He-Qing Wang, Kai-Pu Jin, Li Yang, Hao Liu, Yuan Ji, Cai-Xia Fu, Meng-Su Zeng
PURPOSE: To investigate the value of diffusion kurtosis imaging (DKI) histogram analysis in assessing liver regeneration and the microstructure basis after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), in comparison with portal vein ligation (PVL). MATERIALS AND METHODS: Thirty rats were divided into the ALPPS, PVL, and control groups. Histograms of DKI using a 3T magnetic resonance imaging (MRI) scanner were performed for corrected apparent diffusion (D), kurtosis (K), and apparent diffusion coefficient (ADC)...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28634366/quantifying-non-ergodicity-of-anomalous-diffusion-with-higher-order-moments
#13
Maria Schwarzl, Aljaž Godec, Ralf Metzler
Anomalous diffusion is being discovered in a fast growing number of systems. The exact nature of this anomalous diffusion provides important information on the physical laws governing the studied system. One of the central properties analysed for finite particle motion time series is the intrinsic variability of the apparent diffusivity, typically quantified by the ergodicity breaking parameter EB. Here we demonstrate that frequently EB is insufficient to provide a meaningful measure for the observed variability of the data...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634047/the-study-of-the-intervertebral-disc-microstructure-in-matured-rats-with-diffusion-kurtosis-imaging
#14
Li Li, Wenzhen Zhu, Weiwei Chen, Jicheng Fang, Jing Li
OBJECTIVES: The aim of this study was to use DKI to detect the microstructural change of the discs in matured normal rats. METHODS: Total 24 normal SD rats (12 males/12 females) underwent DWI/DKI and T2 sequences with a 3T MRI scanner to get the values of ADC, FA, MD, Da, Dr, MK, Ka and Kr. The discs were categorized using a five-grade degeneration grading system in the T2-images. The height of the discs and the parameters in DWI/DKI were measured to compare between the different grades and sexes...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28629955/correlation-study-between-dki-and-conventional-dwi-in-brain-and-head-and-neck-tumors
#15
Silvia Minosse, Simona Marzi, Francesca Piludu, Antonello Vidiri
PURPOSE: To investigate the relationship between the Diffusion Kurtosis Imaging (DKI) parameters and conventional metrics provided by Diffusion-weighted imaging (DWI) in patients affected by Brain or Head and Neck (HN) cancer. METHODS: Ten patients affected by brain tumor and nine patients with HN tumor underwent a pre-treatment MR examination at 3 T. The largest tumor section was manually contoured by two expert neuroradiologists. The apparent diffusion coefficient (Dapp) and apparent diffusional kurtosis (Kapp) parameters were determined at the voxel level by using the DKI model, and compared to the apparent diffusion coefficient (ADC) and the tissue diffusion coefficient (Dmono) obtained from mono-exponential fitting methods...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28628946/structural-plasticity-of-the-ventral-stream-and-aphasia-recovery
#16
Emilie T McKinnon, Julius Fridriksson, G Russell Glenn, Jens H Jensen, Joseph A Helpern, Alexandra Basilakos, Christopher Rorden, Andy Y Shih, M Vittoria Spampinato, Leonardo Bonilha
Re-strengthening of the residual language network is likely crucial for speech recovery in post-stroke aphasia. Eight participants with chronic aphasia received intensive speech therapy for three weeks, with standardized naming tests and brain MRIs before and after therapy. Kurtosis-based diffusion tensor tractography was used to measure mean kurtosis (MK) along a segment of the inferior longitudinal fasciculus (ILF). Therapy related reduction in the number of semantic but not phonemic errors was associated with strengthening (renormalization) of ILF MK (r=-0...
June 19, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28624925/liver-fibrosis-in-vivo-evaluation-using-intravoxel-incoherent-motion-derived-histogram-metrics-with-histopathologic-findings-at-3-0-t
#17
Fubi Hu, Ru Yang, Zixing Huang, Min Wang, Hanmei Zhang, Xu Yan, Bin Song
PURPOSE: To retrospectively determine the feasibility of intravoxel incoherent motion (IVIM) imaging based on histogram analysis for the staging of liver fibrosis (LF) using histopathologic findings as the reference standard. METHODS: 56 consecutive patients (14 men, 42 women; age range, 15-76, years) with chronic liver diseases (CLDs) were studied using IVIM-DWI with 9 b-values (0, 25, 50, 75, 100, 150, 200, 500, 800 s/mm(2)) at 3.0 T. Fibrosis stage was evaluated using the METAVIR scoring system...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28616727/preliminary-study-of-diffusion-kurtosis-imaging-in-thyroid-nodules-and-its-histopathologic-correlation
#18
Ruo-Yang Shi, Qiu-Ying Yao, Qin-Yi Zhou, Qing Lu, Shi-Teng Suo, Jun Chen, Wen-Jie Zheng, Yong-Ming Dai, Lian-Ming Wu, Jian-Rong Xu
OBJECTIVES: To evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors. METHODS: The study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF)...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28608327/diffusional-kurtosis-imaging-dki-incorporation-into-an-intravoxel-incoherent-motion-ivim-mr-model-to-measure-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-in-healthy-subjects
#19
Aude Pavilla, Giulio Gambarota, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Hervé Saint-Jalmes
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28587542/evaluation-of-cerebral-glioma-using-3t-diffusion-kurtosis-tensor-imaging-and-the-relationship-between-diffusion-kurtosis-metrics-and-tumor-cellularity
#20
Chong Qi, Song Yang, Lanxi Meng, Huiyuan Chen, Zhenlan Li, Sijia Wang, Tao Jiang, Shaowu Li
Purpose To evaluate the clinical utility of diffusion kurtosis tensor imaging in the characterization of cerebral glioma and investigate correlations between diffusion and kurtosis metrics with tumor cellularity. Materials and Methods A group of 163 patients (age: 40.5 ± 11.5 years) diagnosed with cerebral glioma underwent diffusion kurtosis tensor imaging with a 3 T scanner. Diffusion and kurtosis metrics were measured in the solid part of tumors, and their abilities to distinguish between tumor grades was evaluated...
January 1, 2017: Journal of International Medical Research
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