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diffusion kurtosis

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https://www.readbyqxmd.com/read/28926313/toward-a-standardized-approach-to-estimate-kurtosis-in-body-applications-of-a-non-gaussian-diffusion-kurtosis-imaging-model-of-water-diffusion
#1
Marco Giannelli, Chiara Marzi, Mario Mascalchi, Stefano Diciotti, Carlo Tessa
No abstract text is available yet for this article.
October 2017: Radiology
https://www.readbyqxmd.com/read/28915319/an-improved-model-for-prostate-diffusion-incorporating-the-results-of-monte-carlo-simulations-of-diffusion-in-the-cellular-compartment
#2
Nima Gilani, Paul Malcolm, Glyn Johnson
The purpose of this work was to refine a previously published model of prostate diffusion by incorporating improved estimates of cellular diffusivity obtained by Monte Carlo simulation. Stromal and epithelial cell size and intracellular volume fraction in different grades of cancer were determined from histological images. Diffusion in different mixtures of cells, corresponding to different tumor grades, was simulated and cellular apparent diffusion coefficient and kurtosis values determined. These values were incorporated into the previously published model of prostate diffusion and model predictions compared with values found in the literature...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28912282/apparent-diffusion-coefficient-histograms-of-human-papillomavirus-positive-and-human-papillomavirus-negative-head-and-neck-squamous-cell-carcinoma-assessment-of-tumor-heterogeneity-and-comparison-with-histopathology
#3
T de Perrot, V Lenoir, M Domingo Ayllón, N Dulguerov, M Pusztaszeri, M Becker
BACKGROUND AND PURPOSE: Head and neck squamous cell carcinoma associated with human papillomavirus infection represents a distinct tumor entity. We hypothesized that diffusion phenotypes based on the histogram analysis of ADC values reflect distinct degrees of tumor heterogeneity in human papillomavirus-positive and human papillomavirus-negative head and neck squamous cell carcinomas. MATERIALS AND METHODS: One hundred five consecutive patients (mean age, 64 years; range, 45-87 years) with primary oropharyngeal (n = 52) and oral cavity (n = 53) head and neck squamous cell carcinoma underwent MR imaging with anatomic and diffusion-weighted sequences (b = 0, b = 1000 s/mm(2), monoexponential ADC calculation)...
September 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28910821/vascular-disrupting-agent-in-pancreatic-and-hepatic-tumour-allografts-observations-of-location-dependent-efficacy-by-mri-microangiography-and-histomorphology
#4
Ting Yin, Yewei Liu, Ronald Peeters, Yuanbo Feng, Jie Yu, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
BACKGROUND: Tumours growing in organs of different vascular environment could exhibit diverse responses to vascular disrupting agent (VDA). This study was aimed to identify in vivo imaging biomarkers for evaluation of pancreatic and hepatic tumours and comparison of their responses to a VDA Combretastatin A4 Phosphate (CA4P) using multiparametric MRI. METHODS: Male WAG/Rij rats were used for orthotopic pancreatic head tumour and hepatic tumour implantation; tumour growth was monitored by 3D isotropic MRI using a 3...
September 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28900220/diffusion-kurtosis-imaging-evaluating-epithelial-mesenchymal-transition-in-colorectal-carcinoma-xenografts-model-a-preliminary-study
#5
Huanhuan Liu, Wenbin Shen, Caiyuan Zhang, Yanfen Cui, Jinning Li, Tingting Zhang, Weibo Chen, Dengbin Wang
Epithelial-mesenchymal transition (EMT) plays an important role in aggravating invasiveness and metastatic behavior of colorectal cancer (CRC). Identification of EMT is important for structuring treatment strategy, but has not yet been studied by using noninvasive imaging modality. Diffusion kurtosis imaging (DKI) is an advanced diffusion weighted model that could reflect tissue microstructural changes in vivo. In this study, EMT was induced in CRC cells (HCT116) by overexpressing Snail1 gene. We aimed to investigate the value of DKI in identifying EMT in CRC and decipher the correlations between DKI-derived parameters and EMT biomarker E-cadherin and cell proliferative index Ki-67 expression...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894296/test-retest-reliability-of-high-spatial-resolution-diffusion-tensor-and-diffusion-kurtosis-imaging
#6
Pashtun Shahim, Laurena Holleran, Joong H Kim, David L Brody
We assessed the test-retest reliability of high spatial resolution diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI). Diffusion MRI was acquired using a Siemens 3 Tesla Prisma scanner with 80 mT/m gradients and a 32-channel head coil from each of 3 concussive traumatic brain injury (cTBI) patients and 4 controls twice 0 to 24 days apart. Coefficients of variation (CoV) for DTI parameters were calculated in each DTI Studio parcellated white matter tract at 1.25 mm and 1.75 mm isotropic voxel resolution, as well as DKI parameters at 1...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870086/histogram-analysis-of-apparent-diffusion-coefficient-maps-for-the-differentiation-between-lymphoma-and-metastatic-lymph-nodes-of-squamous-cell-carcinoma-in-head-and-neck-region
#7
Yan-Jun Wang, Xiao-Quan Xu, Hao Hu, Guo-Yi Su, Jie Shen, Hai-Bin Shi, Fei-Yun Wu
Background To clarify the nature of cervical malignant lymphadenopathy is highly important for the diagnosis and differential diagnosis of head and neck tumors. Purpose To investigate the role of first-order apparent diffusion coefficient (ADC) histogram analysis for differentiating lymphoma from metastatic lymph nodes of squamous cell carcinoma (SCC) in the head and neck region. Material and Methods Diffusion-weighted imaging (DWI) data of 67 patients (lymphoma, n = 20; SCC, n = 47) with malignant lymphadenopathy were retrospectively analyzed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28865921/in-vivo-assessment-of-tumor-heterogeneity-in-who-2016-glioma-grades-using-diffusion-kurtosis-imaging-diagnostic-performance-and-improvement-of-feasibility-in-routine-clinical-practice
#8
J-M Hempel, J Schittenhelm, S Bisdas, C Brendle, B Bender, G Bier, M Skardelly, G Tabatabai, S Castaneda Vega, U Ernemann, U Klose
PURPOSE: To assess the diagnostic performance of normalized and non-normalized diffusion kurtosis imaging (DKI) metrics extracted from different tumor volume data for grading glioma according to the integrated approach of the revised 2016 WHO classification. MATERIALS AND METHODS: Sixty patients with histopathologically confirmed glioma, who provided written informed consent, were retrospectively assessed between 01/2013 and 08/2016 from a prospective trial approved by the local institutional review board...
September 1, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28856177/intravoxel-incoherent-motion-ivim-histogram-biomarkers-for-prediction-of-neoadjuvant-treatment-response-in-breast-cancer-patients
#9
Gene Y Cho, Lucas Gennaro, Elizabeth J Sutton, Emily C Zabor, Zhigang Zhang, Dilip Giri, Linda Moy, Daniel K Sodickson, Elizabeth A Morris, Eric E Sigmund, Sunitha B Thakur
OBJECTIVE: To examine the prognostic capabilities of intravoxel incoherent motion (IVIM) metrics and their ability to predict response to neoadjuvant treatment (NAT). Additionally, to observe changes in IVIM metrics between pre- and post-treatment MRI. METHODS: This IRB-approved, HIPAA-compliant retrospective study observed 31 breast cancer patients (32 lesions). Patients underwent standard bilateral breast MRI along with diffusion-weighted imaging before and after NAT...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28845175/microstructural-abnormalities-of-basal-ganglia-and-thalamus-in-bipolar-and-unipolar-disorders-a-diffusion-kurtosis-and-perfusion-imaging-study
#10
Lianping Zhao, Ying Wang, Yanbin Jia, Shuming Zhong, Yao Sun, Zhifeng Zhou, Zhongping Zhang, Li Huang
OBJECTIVE: Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD. METHODS: Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28841758/precision-and-accuracy-of-diffusion-kurtosis-estimation-and-the-influence-of-b-value-selection
#11
Andrey Chuhutin, Brian Hansen, Sune Nørhøj Jespersen
Diffusion kurtosis imaging (DKI) is an extension of diffusion tensor imaging that accounts for leading non-Gaussian diffusion effects. In DKI studies, a wide range of different gradient strengths (b-values) is used, which is known to affect the estimated diffusivity and kurtosis parameters. Hence there is a need to assess the accuracy and precision of the estimated parameters as a function of b-value. This work examines the error in the estimation of mean of the kurtosis tensor (MKT) with respect to the ground truth, using simulations based on a biophysical model for both gray (GM) and white (WM) matter...
August 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28834443/diffusion-kurtosis-imaging-helps-to-predict-upgrading-in-biopsy-proven-prostate-cancer-with-a-gleason-score-of-6
#12
Chen-Jiang Wu, Yu-Dong Zhang, Mei-Ling Bao, Hai Li, Xiao-Ning Wang, Xi-Sheng Liu, Hai-Bin Shi
OBJECTIVE: The purpose of this study was to investigate whether diffusion kurtosis imaging (DKI) is useful for predicting upgrades in Gleason score (GS) in biopsy-proven prostate cancer with a GS of 6. MATERIALS AND METHODS: A total of 46 patients with biopsy-proven GS 6 prostate cancer, 3-T DWI results, and surgical pathologic results were retrospectively included in the study. DWI data were postprocessed with monoexponential and DK models to quantify the apparent diffusion coefficient (ADC), apparent diffusion for gaussian distribution (Dapp), and apparent kurtosis coefficient (Kapp)...
August 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28834322/lipid-metabolism-abdominal-adiposity-and-cerebral-health-in-the-amish
#13
Meghann Ryan, Peter Kochunov, Laura M Rowland, Braxton D Mitchell, S Andrea Wijtenburg, Els Fieremans, Jelle Veraart, Dmitry S Novikov, Xiaoming Du, Bhim Adhikari, Feven Fisseha, Heather Bruce, Joshua Chiappelli, Hemalatha Sampath, Seth Ament, Jeffrey O'Connell, Alan R Shuldiner, L Elliot Hong
OBJECTIVE: To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA). METHODS: Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA (N = 64, 31 males/33 females, ages 18-77). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole-brain average cortical thickness...
August 20, 2017: Obesity
https://www.readbyqxmd.com/read/28820864/diffusion-kurtosis-imaging-and-pathology-in-spinal-cord-ischemia-reperfusion-injury-in-rabbits-a-case-control-study
#14
Daowei Li, Xiaoming Wang
BACKGROUND The aim of this study was to evaluate the application of diffusion kurtosis imaging (DKI) in spinal cord ischemia/reperfusion (SCI/R) injury and to explore its association with pathology. MATERIAL AND METHODS Japanese male long-eared rabbits were chosen and divided into 7 groups (8 rabbits in each group): control group (C group), sham-operation control group (S group), and 5 experimental groups (E-2 h group, E-24 h group, E-48 h group, E-7 d group, and E-14 d group). Tarlov scoring and immunohistochemical staining were used to assess hindlimb motor function and observe the expression of glial fiber acidic protein (GFAP), respectively...
August 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28818694/diffusion-time-dependence-of-microstructural-parameters-in-fixed-spinal-cord
#15
REVIEW
Sune Nørhøj Jespersen, Jonas Lynge Olesen, Brian Hansen, Noam Shemesh
Biophysical modelling of diffusion MRI is necessary to provide specific microstructural tissue properties. However, estimating model parameters from data with limited diffusion gradient strength, such as clinical scanners, has proven unreliable due to a shallow optimization landscape. On the other hand, estimation of diffusion kurtosis (DKI) parameters is more robust, and its parameters may be connected to microstructural parameters, given an appropriate biophysical model. However, it was previously shown that this procedure still does not provide sufficient information to uniquely determine all model parameters...
August 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28813235/temporary-hearing-threshold-shift-in-healthy-volunteers-with-hearing-protection-caused-by-acoustic-noise-exposure-during-3-t-multisequence-mr-neuroimaging
#16
Chao Jin, Huan Li, Xianjun Li, Miaomiao Wang, Congcong Liu, Jianxin Guo, Jian Yang
Purpose To determine whether a single 51-minute exposure to acoustic noise during 3-T multisequence magnetic resonance (MR) neuroimaging could affect the hearing threshold of healthy adults with earplugs and sponge mats as hearing protection. Materials and Methods With earplugs and motion-refraining sponge mats as hearing protection, 26 healthy young adults underwent 3-T MR neuroimaging imaging that included T1-weighted three-dimensional gradient-echo sequence, T2-weighted fast spin-echo sequence, diffusion-tensor imaging, diffusion-kurtosis imaging, T2*-weighted three-dimensional multiecho gradient-echo sequence, and blood oxygen level-dependent imaging...
August 16, 2017: Radiology
https://www.readbyqxmd.com/read/28813200/brain-microstructural-abnormalities-in-patients-with-cirrhosis-without-overt-hepatic-encephalopathy-a-voxel-based-diffusion-kurtosis-imaging-study
#17
Hua-Jun Chen, Peng-Fei Liu, Qiu-Feng Chen, Hai-Bin Shi
OBJECTIVE: This study aimed to investigate whole-brain microstructural abnormalities and their correlation with cognitive impairment in patients with cirrhosis using diffusion kurtosis imaging (DKI). SUBJECTS AND METHODS: Eighteen patients with cirrhosis and 17 healthy control subjects underwent DKI. Cognition was measured using psychometric hepatic encephalopathy (HE) scores. Whole-brain voxel-based analyses were performed to investigate between-group differences in DKI-derived parameters, including mean kurtosis, axial kurtosis, and radial kurtosis...
August 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28781902/study-on-lesion-assessment-of-cerebello-thalamo-cortical-network-in-wilson-s-disease-with-diffusion-tensor-imaging
#18
Anqin Wang, Hongli Wu, Chunsheng Xu, Lanfeng Tang, Jaeyoun Lee, Min Wang, Man Jiang, Chuanfu Li, Qi Lu, Chunyun Zhang
Wilson's disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). The DTI parameters, including fractional anisotropy (FA) and mean diffusion (MD), were calculated by diffusion kurtosis estimator software...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28774682/methods-for-molecular-imaging-of-brain-tumours-in-a-hybrid-mr-pet-context-water-content-t2%C3%A2-diffusion-indices-and-fet-pet
#19
A M Oros-Peusquens, R Loução, M Zimmermann, K-J Langen, N J Shah
The aim of this study is to present and evaluate a multiparametric and multi-modality imaging protocol applied to brain tumours and investigate correlations between these different imaging measures (R1.1). In particular, we describe a method for rapid, non-invasive, quantitative imaging of water content of brain tissue, based on a single multiple-echo gradient-echo (mGRE) acquisition. We include in the processing a method for noise reduction of the multi-contrast data based on Principal Component Analysis (PCA)...
July 31, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28774471/quantitative-evaluation-of-diffusion-kurtosis-imaging-for-grading-endometrial-carcinoma-a-comparative-study-with-diffusion-weighted-imaging
#20
T Chen, Y Li, S-S Lu, Y-D Zhang, X-N Wang, C-Y Luo, H-B Shi
AIM: To evaluate the diagnostic performance of histogram analysis of diffusion kurtosis magnetic resonance imaging (DKI) and standard diffusion-weighted imaging (DWI) in discriminating tumour grades of endometrial carcinoma (EC). MATERIALS AND METHODS: Seventy-three patients with EC were included in this study. The apparent diffusion coefficient (ADC) value from standard DWI, apparent diffusion for Gaussian distribution (Dapp), and apparent kurtosis coefficient (Kapp) from DKI were acquired using a 3 T magnetic resonance imaging (MRI) system...
July 31, 2017: Clinical Radiology
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