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diffusion kurtosis

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https://www.readbyqxmd.com/read/29782920/whole-lesion-histogram-analysis-of-meningiomas-derived-from-adc-values-correlation-with-several-cellularity-parameters-proliferation-index-ki-67-nucleic-content-and-membrane-permeability
#1
Alexey Surov, Gordian Hamerla, Hans Jonas Meyer, Karsten Winter, Stefan Schob, Eckhard Fiedler
PURPOSE: To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. MATERIALS AND METHODS: The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADCmean , ADCmax , ADCmin , ADCmedian , ADCmode , ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy...
May 18, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29766933/corticospinal-tract-changes-in-acute-brainstem-ischemic-stroke-patients-a-diffusion-kurtosis-imaging-study
#2
Huiyou Chen, Liang Jiang, Hong Zhang, Ying-Dong Zhang, Wen Geng, Yuan Feng, Qian Chen, Yu-Chen Chen, Xindao Yin
Purpose: The present study aimed to investigate the corticospinal tract (CST) changes in patients with brainstem ischemic stroke by using the diffusion kurtosis imaging (DKI) approach.. Materials and Methods: Twenty-one patients with brainstem stroke and 21 group-matched healthy controls underwent brain DKI with 3.0 T magnetic resonance imaging (MRI). The DKI was obtained by using three b values of 0, 1,000, 2,000 s/mm2 with 15 diffusion directions. Regions of interest (ROIs) were placed at four levels: the pons, posterior limb of the internal capsule (PLIC), corona radiata, and precentral gyrus...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29761118/susceptibility-weighted-and-diffusion-kurtosis-imaging-to-evaluate-encephalomalacia-with-epilepsy-after-traumatic-brain-injury
#3
Wenbin Li, Xuan Wang, Xiaoer Wei, Mingliang Wang
Objective: Encephalomalacia after traumatic brain injury (TBI) is one of the factors leading to epilepsy. In this study, magnetic resonance imaging (MRI) was used to explore the brain image features of epilepsy after traumatic encephalomalacia, and to provide objective evidence for predicting the possible occurrence of epilepsy after traumatic encephalomalacia. Methods: Two-hundred-fifty-two patients with traumatic encephalomalacia were prospectively enrolled in the study...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29748203/comparative-analysis-of-diffusional-kurtosis-imaging-diffusion-tensor-imaging-and-diffusion-weighted-imaging-in-grading-and-assessing-cellular-proliferation-of-meningiomas
#4
L Lin, R Bhawana, Y Xue, Q Duan, R Jiang, H Chen, X Chen, B Sun, H Lin
BACKGROUND AND PURPOSE: An accurate evaluation of the World Health Organization grade and cellular proliferation is particularly important in meningiomas. Our aim was to prospectively evaluate and compare diffusional kurtosis imaging, DTI, and DWI metrics in determining the grade and cellular proliferation of meningiomas. MATERIALS AND METHODS: Ninety-six consecutive patients with histopathologically confirmed meningiomas were included in this study. Mean kurtosis, radial kurtosis, axial kurtosis, fractional anisotropy, mean diffusivity, and ADC were semiautomatically obtained in the solid components of tumors...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29740660/differentiation-between-malignant-and-benign-musculoskeletal-tumors-using-diffusion-kurtosis-imaging
#5
Masaki Ogawa, Hirohito Kan, Nobuyuki Arai, Taro Murai, Yoshihiko Manabe, Yusuke Sawada, Yuta Shibamoto
OBJECTIVE: The purpose of this study was to evaluate differences in parameters of diffusion kurtosis imaging (DKI) and minimum apparent diffusion coefficient (ADCmin ) between benign and malignant musculoskeletal tumors. MATERIALS AND METHODS: In this prospective study, 43 patients were scanned using a DKI protocol on a 3-T MR scanner. Eligibility criteria were: non-fatty, non-cystic soft tissue or osteolytic tumors; > 2 cm; location in the retroperitoneum, pelvis, leg, or neck; and no prior treatment...
May 9, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29725833/oesophageal-squamous-cell-carcinoma-histogram-derived-adc-parameters-are-not-predictive-of-tumour-response-to-chemoradiotherapy
#6
Maiko Kozumi, Hideki Ota, Takaya Yamamoto, Rei Umezawa, Haruo Matsushita, Yojiro Ishikawa, Noriyoshi Takahashi, Tomonori Matsuura, Kei Takase, Keiichi Jingu
OBJECTIVES: To evaluate correlations between tumour response to definitive chemoradiotherapy (CRT) in oesophageal squamous cell carcinoma (SCC) and histogram-derived apparent diffusion coefficient (ADC) parameters on diffusion-weighted MR images. METHODS: Forty patients with clinical T3-4 oesophageal SCC underwent concurrent CRT. MR examination at 3 T was performed 1-3 days prior to CRT. Readout-segmented echo-planar diffusion imaging was used to acquire ADC maps...
May 3, 2018: European Radiology
https://www.readbyqxmd.com/read/29719853/reconstruction-of-white-matter-fibre-tracts-using-diffusion-kurtosis-tensor-imaging-at-1-5t-pre-surgical-planning-in-patients-with-gliomas
#7
Joao Leote, Rita G Nunes, Luis Cerqueira, Ricardo Loução, Hugo A Ferreira
Tractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. Purpose: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1...
2018: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29719719/divergent-topological-networks-in-alzheimer-s-disease-a-diffusion-kurtosis-imaging-analysis
#8
Jia-Xing Cheng, Hong-Ying Zhang, Zheng-Kun Peng, Yao Xu, Hui Tang, Jing-Tao Wu, Jun Xu
Background: Brain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (DKI) is a tool to determine brain non-Gaussian diffusion properties. We investigated the network properties of DKI parameters in the whole brain using graph theory and further detected the alterations of the DKI networks in Alzheimer's disease (AD). Methods: Magnetic resonance DKI scanning was performed on 21 AD patients and 19 controls...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29719621/histogram-analysis-of-adc-in-rectal-cancer-associations-with-different-histopathological-findings-including-expression-of-egfr-hif1-alpha-vegf-p53-pd1-and-ki-67-a-preliminary-study
#9
Hans Jonas Meyer, Annekathrin Höhn, Alexey Surov
Functional imaging modalities like Diffusion-weighted imaging are increasingly used to predict tumor behavior like cellularity and vascularity in different tumors. Histogram analysis is an emergent imaging analysis, in which every voxel is used to obtain a histogram and therefore statistically information about tumors can be provided. The purpose of this study was to elucidate possible associations between ADC histogram parameters and several immunhistochemical features in rectal cancer. Overall, 11 patients with histologically proven rectal cancer were included into the study...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717790/use-of-diffusion-kurtosis-imaging-and-quantitative-dynamic-contrast-enhanced-mri-for-the-differentiation-of-breast-tumors
#10
Ting Li, Tao Yu, Lyu Li, Lunbo Lu, Yaoyao Zhuo, Jingge Lian, Yun Xiong, Dexing Kong, Kangan Li
BACKGROUND: Breast MRI is a sensitive imaging technique to assess breast cancer but its effectiveness still remains to be improved. PURPOSE: To evaluate the diagnostic performance of diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), and quantitative dynamic contrast-enhanced (DCE)-MRI in differentiating malignant from benign breast lesions independently or jointly and to explore whether correlations exist among these parameters. STUDY TYPE: Retrospective...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29716527/differentiation-of-orbital-lymphoma-and-idiopathic-orbital-inflammatory-pseudotumor-combined-diagnostic-value-of-conventional-mri-and-histogram-analysis-of-adc-maps
#11
Jiliang Ren, Ying Yuan, Yingwei Wu, Xiaofeng Tao
BACKGROUND: The overlap of morphological feature and mean ADC value restricted clinical application of MRI in the differential diagnosis of orbital lymphoma and idiopathic orbital inflammatory pseudotumor (IOIP). In this paper, we aimed to retrospectively evaluate the combined diagnostic value of conventional magnetic resonance imaging (MRI) and whole-tumor histogram analysis of apparent diffusion coefficient (ADC) maps in the differentiation of the two lesions. METHODS: In total, 18 patients with orbital lymphoma and 22 patients with IOIP were included, who underwent both conventional MRI and diffusion weighted imaging before treatment...
May 2, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29713222/utility-of-readout-segmented-echo-planar-imaging-based-diffusion-kurtosis-imaging-for-differentiating-malignant-from-benign-masses-in-head-and-neck-region
#12
Gao Ma, Xiao-Quan Xu, Hao Hu, Guo-Yi Su, Jie Shen, Hai-Bin Shi, Fei-Yun Wu
Objective: To compare the diagnostic performance of readout-segmented echo-planar imaging (RS-EPI)-based diffusion kurtosis imaging (DKI) and that of diffusion-weighted imaging (DWI) for differentiating malignant from benign masses in head and neck region. Materials and Methods: Between December 2014 and April 2016, we retrospectively enrolled 72 consecutive patients with head and neck masses who had undergone RS-EPI-based DKI scan (b value of 0, 500, 1000, and 1500 s/mm2 ) for pretreatment evaluation...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29705041/white-matter-biomarkers-from-diffusion-mri
#13
Sune Nørhøj Jespersen
As part of an issue celebrating 2 decades of Joseph Ackerman editing the Journal of Magnetic Resonance, this paper reviews recent progress in one of the many areas in which Ackerman and his lab has made significant contributions: NMR measurement of diffusion in biological media, specifically in brain tissue. NMR diffusion signals display exquisite sensitivity to tissue microstructure, and have the potential to offer quantitative and specific information on the cellular scale orders of magnitude below nominal image resolution when combined with biophysical modeling...
April 25, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29704561/oral-carcinoma-clinical-evaluation-using-diffusion-kurtosis-imaging-and-its-correlation-with-histopathologic-findings
#14
Ichiro Yamada, Norio Yoshino, Keigo Hikishima, Junichiro Sakamoto, Misaki Yokokawa, Yu Oikawa, Hiroyuki Harada, Tohru Kurabayashi, Yukihisa Saida, Ukihide Tateishi, Akane Yukimori, Toshiyuki Izumo, Shun Asahina
PURPOSE: In this study, we aimed to determine the usefulness of diffusion kurtosis imaging (DKI) as a noninvasive method for evaluation of the histologic grade and lymph node metastasis in patients with oral carcinoma. MATERIALS AND METHODS: Twenty-seven patients with oral carcinoma were examined with a 3-T MR system and 16-channel coil. DKI data were obtained by a single-shot echo-planar imaging sequence with repetition time, 10,000 ms; echo time, 94 ms; field of view, 250 × 204...
April 25, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29698450/stroke-infarct-volume-estimation-in-fixed-tissue-comparison-of-diffusion-kurtosis-imaging-to-diffusion-weighted-imaging-and-histology-in-a-rodent-mcao-model
#15
Vibeke Bay, Birgitte F Kjølby, Nina K Iversen, Irene K Mikkelsen, Maryam Ardalan, Jens R Nyengaard, Sune N Jespersen, Kim R Drasbek, Leif Østergaard, Brian Hansen
Diffusion kurtosis imaging (DKI) is a new promising MRI technique with microstructural sensitivity superior to conventional diffusion tensor (DTI) based methods. In stroke, considerable mismatch exists between the infarct lesion outline obtained from the two methods, kurtosis and diffusion tensor derived metrics. We aim to investigate if this mismatch can be examined in fixed tissue. Our investigation is based on estimates of mean diffusivity (MD) and mean (of the) kurtosis tensor (MKT) obtained using recent fast DKI methods requiring only 19 images...
2018: PloS One
https://www.readbyqxmd.com/read/29693765/integrating-dynamic-contrast-enhanced-magnetic-resonance-imaging-and-diffusion-kurtosis-imaging-for-neoadjuvant-chemotherapy-assessment-of-nasopharyngeal-carcinoma
#16
Dechun Zheng, Guojing Lai, Ying Chen, Qiuyuan Yue, Xiangyi Liu, Xiaodan Chen, Weibo Chen, Queenie Chan, Yunbin Chen
BACKGROUND: Since neoadjuvant chemotherapy (NAC) has proven a benefit for locally advanced nasopharyngeal carcinoma (NPC), early response evaluation after chemotherapy is important to implement individualized therapy for NPC in the era of precision medicine. PURPOSE: To determine the combined and independent contribution between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion kurtosis imaging (DKI) in the early monitoring of NAC response for NPC...
April 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29682188/imaging-markers-of-response-to-combined-braf-and-mek-inhibition-in-braf-mutated-vemurafenib-sensitive-and-resistant-melanomas
#17
Stefania Acciardo, Lionel Mignion, Nicolas Joudiou, Caroline Bouzin, Jean-François Baurain, Bernard Gallez, Bénédicte F Jordan
A majority of patients with a V600x melanoma respond quickly to BRAF/MEK inhibition (BRAFi/MEKi) and have an obvious clinical benefit. Nearly all the patients after this initial phase will develop resistance. Therefore, non-invasive early markers of response/non-response are needed in order to identify those patients who, due to intrinsic or acquired resistance, do not respond to treatment and would be eligible for alternative treatments. The aim of this study was to investigate the value of magnetic resonance spectroscopy (1 H-MRS) of choline and diffusion-weighted magnetic resonance imaging (DW-MRI) as early markers of response to BRAF inhibition (BRAFi) with vemurafenib alone or in combination with MEK inhibition (MEKi) with trametinib, in BRAFi-sensitive and BRAFi-resistant melanoma xenografts...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680253/longitudinal-study-of-irradiation-induced-brain-microstructural-alterations-with-s-index-a-diffusion-mri-biomarker-and-mr-spectroscopy
#18
Elodie Anne Pérès, Olivier Etienne, Antoine Grigis, Fawzi Boumezbeur, François Dominique Boussin, Denis Le Bihan
PURPOSE: Radiation therapy is widely used for the treatment of brain tumors, but it may lead to severe cognitive impairments. Previous studies have shown that ionizing irradiation induces demyelination, blood-brain barrier alterations, and impaired neurogenesis in animal models. Hence, noninvasive and sensitive biomarkers of irradiation injury are needed to investigate these effects in patients and improve radiation therapy protocols. METHODS AND MATERIALS: The heads of 3-month-old male C57BL/6RJ mice (15 control mice and 15 irradiated mice) were exposed to radiation doses of 3 fractions of 5 Gy from a 60 Co source with a medical irradiator...
February 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29678540/quantitative-diffusion-mri-using-reduced-field-of-view-and-multi-shot-acquisition-techniques-validation-in-phantoms-and-prostate-imaging
#19
Yuxin Zhang, James Holmes, Iñaki Rabanillo, Arnaud Guidon, Shane Wells, Diego Hernando
PURPOSE: To evaluate the reproducibility of quantitative diffusion measurements obtained with reduced Field of View (rFOV) and Multi-shot EPI (msEPI) acquisitions, using single-shot EPI (ssEPI) as a reference. METHODS: Diffusion phantom experiments, and prostate diffusion-weighted imaging in healthy volunteers and patients with known or suspected prostate cancer were performed across the three different sequences. Quantitative diffusion measurements of apparent diffusion coefficient, and diffusion kurtosis parameters (healthy volunteers), were obtained and compared across diffusion sequences (rFOV, msEPI, and ssEPI)...
April 17, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29676939/diffusion-kurtosis-imaging-in-the-differential-diagnosis-of-parotid-gland-disease-and-parotid-adenolymphoma-preliminary-results
#20
Shun Yu, Zhongshuai Zhang, Bao Qiang, S U Jiawei, Mengxiao Liu, Qinglei Shi, Wenchao Cai
PURPOSE: To study the value of diffusion kurtosis imaging (DKI) in diagnosis of parotid gland disease (PGD) with different pathological patterns and parotid adenolymphoma (PAL). METHODS: Fifty-seven patients with different kinds of PGD were enrolled and underwent DKI and conventional diffusion-weighted imaging (DWI). All patients were categorized into different groups according to their pathological patterns. The result of calculating the value of DKI-derived parameters (Kmean, Krad, Kax, Dmean, Drad, Dax, and FA) and apparent diffusion coefficient (ADC) of DWI were used to study their diagnostic accuracy in PGD with different pathological patterns...
April 20, 2018: Dento Maxillo Facial Radiology
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