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diffusion kurtosis

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https://www.readbyqxmd.com/read/28532604/validation-of-dwi-pre-processing-procedures-for-reliable-differentiation-between-human-brain-gliomas
#1
Sebastian Vellmer, Aram S Tonoyan, Dieter Suter, Igor N Pronin, Ivan I Maximov
Diffusion magnetic resonance imaging (dMRI) is a powerful tool in clinical applications, in particular, in oncology screening. dMRI demonstrated its benefit and efficiency in the localisation and detection of different types of human brain tumours. Clinical dMRI data suffer from multiple artefacts such as motion and eddy-current distortions, contamination by noise, outliers etc. In order to increase the image quality of the derived diffusion scalar metrics and the accuracy of the subsequent data analysis, various pre-processing approaches are actively developed and used...
May 19, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28525383/histogram-analysis-of-diffusion-kurtosis-imaging-of-nasopharyngeal-carcinoma-correlation-between-quantitative-parameters-and-clinical-stage
#2
Xiao-Quan Xu, Gao Ma, Yan-Jun Wang, Hao Hu, Guo-Yi Su, Hai-Bin Shi, Fei-Yun Wu
PURPOSE: To evaluate the correlation between histogram parameters derived from diffusion-kurtosis (DK) imaging and the clinical stage of nasopharyngeal carcinoma (NPC). RESULTS: High T-stage (T3/4) NPC showed significantly higher Kapp-mean (P = 0.018), Kapp-median (P = 0.029) and Kapp-90th (P = 0.003) than low T-stage (T1/2) NPC. High N-stage NPC (N2/3) showed significantly lower Dapp-mean (P = 0.002), Dapp-median (P = 0.002) and Dapp-10th (P < 0.001) than low N-stage NPC (N0/1)...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28515412/utility-of-a-hybrid-ivim-dki-model-to-predict-the-development-of-distant-metastasis-in-head-and-neck-squamous-cell-carcinoma-patients
#3
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Daisuke Yoshida, Kohsuke Kudo, Hiroki Shirato
PURPOSE: To evaluate the diagnostic power of hybrid intravoxel incoherent motion (IVIM)-diffusion kurtosis imaging (DKI) model parameters in pretreatment for the prediction of future distant metastasis in head and neck squamous cell carcinoma (HNSCC) patients. MATERIALS AND METHODS: We retrospectively evaluated 49 HNSCC patients who underwent curative chemoradiation therapy. Diffusion-weighted image (DWI) acquired by single-shot spin-echo echo-planar imaging with 12 b-values (0-2000) was performed in all patients before any treatment...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28514763/the-value-of-diffusion-kurtosis-imaging-in-assessing-pathological-complete-response-to-neoadjuvant-chemoradiation-therapy-in-rectal-cancer-a-comparison-with-conventional-diffusion-weighted-imaging
#4
Feixiang Hu, Wei Tang, Yiqun Sun, Dang Wan, Sanjun Cai, Zhen Zhang, Robert Grimm, Xu Yan, Caixia Fu, Tong Tong, Weijun Peng
OBJECTIVES: The aim of this study is to comprehensively evaluate the advantage of diffusion kurtosis imaging (DKI) in distinguishing pathological complete response (pCR) from non-pCR patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation therapy (CRT) in comparison to conventional diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Fifty-six consecutive patients diagnosed with LARC were prospectively enrolled and underwent pre- and post-CRT MRI on a 3...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28509567/early-evaluation-of-radiation-induced-parotid-damage-with-diffusion-kurtosis-imaging-a-preliminary-study
#5
Nan Zhou, Weibo Chen, Xia Pan, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
Background Radiation-induced parotid gland damage is a common complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC), which always causes xerostomia, dysphagia, dental caries, and even sleep disorders. Early evaluation of radiation-induced parotid damage is required to facilitate early interventions. Purpose To early-evaluate radiation-induced parotid damage using diffusion kurtosis imaging (DKI) in patients with NPC undergoing RT. Material and Methods Thirty-two patients with NPC underwent DKI for parotid glands pre-RT (two weeks before RT), mid-RT (five weeks after RT began), and post-RT (four weeks after RT)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28508679/comparison-of-fdg-pet-metabolic-tumour-volume-versus-adc-histogram-prognostic-value-of-tumour-treatment-response-and-survival-in-patients-with-locally-advanced-uterine-cervical-cancer
#6
Yoshiko Ueno, Robert Lisbona, Tsutomu Tamada, Amer Alaref, Kazuro Sugimura, Caroline Reinhold
OBJECTIVE: To evaluate the prognostic utility of volume-based parameters of fluorine 18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) and apparent diffusion coefficient (ADC) histogram analysis for tumour response to therapy and event-free survival (EFS) in patients with uterine cervical cancer receiving chemoradiotherapy (CRT). METHODS: The study included 21 patients diagnosed as locally advanced uterine cervical cancer who underwent pre-treatment MRI and (18)F-FDG PET and were treated with concurrent CRT...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28485734/the-effect-of-crack-cocaine-addiction-and-age-on-the-microstructure-and-morphology-of-the-human-striatum-and-thalamus-using-shape-analysis-and-fast-diffusion-kurtosis-imaging
#7
E A Garza-Villarreal, M M Chakravarty, B Hansen, S F Eskildsen, G A Devenyi, D Castillo-Padilla, T Balducci, E Reyes-Zamorano, S N Jespersen, P Perez-Palacios, R Patel, J J Gonzalez-Olvera
The striatum and thalamus are subcortical structures intimately involved in addiction. The morphology and microstructure of these have been studied in murine models of cocaine addiction (CA), showing an effect of drug use, but also chronological age in morphology. Human studies using non-invasive magnetic resonance imaging (MRI) have shown inconsistencies in volume changes, and have also shown an age effect. In this exploratory study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack CA compared to matched healthy controls (HCs), while investigating the effect of age and years of cocaine consumption...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28484279/diffusion-kurtosis-imaging-of-microstructural-alterations-in-the-brains-of-paediatric-patients-with-congenital-sensorineural-hearing-loss
#8
Wenbin Zheng, Chunxiao Wu, Lexing Huang, Renhua Wu
Our aim was to assess microstructural alterations in the cerebrums of paediatric patients with congenital sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI). Seventy-two paediatric SNHL patients and 38 age-matched healthy volunteers were examined via DKI using a 3.0 T magnetic resonance (MR) imager. Fractional anisotropy (FA) and mean kurtosis (MK) values were computed for 12 cerebral regions in both the controls and the SNHL patients. Compared with patients below age 3, patients in the older age group were found to have more significant differences in MK than in FA, and these appeared in more major areas of the brain...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28480613/efficient-experimental-designs-for-isotropic-generalized-diffusion-tensor-mri-igdti
#9
Alexandru V Avram, Joelle E Sarlls, Elizabeth Hutchinson, Peter J Basser
PURPOSE: We propose a new generalized diffusion tensor imaging (GDTI) experimental design and analysis framework for efficiently measuring orientationally averaged diffusion-weighted images (DWIs), which remove bulk signal modulations attributed to diffusion anisotropy and quantify isotropic higher-order diffusion tensors (HOT). We illustrate how this framework accelerates the clinical measurement of rotation-invariant tissue microstructural parameters derived from HOT, such as the HOT-Trace and the mean t-kurtosis...
May 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28473339/diffusional-kurtosis-imaging-and-motor-outcome-in-acute-ischemic-stroke
#10
M V Spampinato, C Chan, J H Jensen, J A Helpern, L Bonilha, S A Kautz, P J Nietert, W Feng
BACKGROUND AND PURPOSE: Motor impairment is the most common deficit after stroke. Our aim was to evaluate whether diffusional kurtosis imaging can detect corticospinal tract microstructural changes in the acute phase for patients with first-ever ischemic stroke and motor impairment and to assess the correlations between diffusional kurtosis imaging-derived diffusion metrics for the corticospinal tract and motor impairment 3 months poststroke. MATERIALS AND METHODS: We evaluated 17 patients with stroke who underwent brain MR imaging including diffusional kurtosis imaging within 4 days after the onset of symptoms...
May 4, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28471524/non-gaussian-diffusion-evaluation-of-the-human-kidney-by-pad%C3%A3-exponent-model
#11
Alexandra Ljimani, Rotem S Lanzman, Anja Müller-Lutz, Gerald Antoch, Hans-Jörg Wittsack
PURPOSE: To evaluate the feasibility of renal diffusion quantification using the Padé exponent model (PEM) in healthy subjects. MATERIALS AND METHODS: Diffusion measurements were completed in 10 healthy subjects (mean age, 32.4 ± 8.9 years) on a 3T MRI scanner (Magnetom Trio, Siemens AG, Germany). A respiratory-triggered echo planar imaging sequence (15 slices with 6 mm thickness; 16 b-values [0-750 s/mm(2) ]; three diffusion directions; field of view: 400 × 375 mm; Matrix 192 × 192; repetition time/echo time: 3000/74 ms) was acquired in the coronal direction...
May 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28470878/gray-matter-abnormalities-in-idiopathic-parkinson-s-disease-evaluation-by-diffusional-kurtosis-imaging-and-neurite-orientation-dispersion-and-density-imaging
#12
Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensitive brain imaging techniques is essential to facilitate early diagnosis and assessment of disease severity. GM microstructure was assessed with GM-based spatial statistics applied to diffusion kurtosis imaging (DKI) and neurite orientation dispersion imaging (NODDI) in 30 participants with PD and 28 age- and gender-matched controls. These were compared with currently used assessment methods such as diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and surface-based cortical thickness analysis...
May 4, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28454487/diffusion-kurtosis-imaging-of-the-liver-at-3-tesla-in%C3%A2-vivo-comparison-to-standard-diffusion-weighted-imaging
#13
Johannes Budjan, Elke A Sauter, Frank G Zoellner, Andreas Lemke, Jens Wambsganss, Stefan O Schoenberg, Ulrike I Attenberger
Background Functional techniques like diffusion-weighted imaging (DWI) are gaining more and more importance in liver magnetic resonance imaging (MRI). Diffusion kurtosis imaging (DKI) is an advanced technique that might help to overcome current limitations of DWI. Purpose To evaluate DKI for the differentiation of hepatic lesions in comparison to conventional DWI at 3 Tesla. Material and Methods Fifty-six consecutive patients were examined using a routine abdominal MR protocol at 3 Tesla which included DWI with b-values of 50, 400, 800, and 1000 s/mm(2)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28448817/automated-detection-of-pathologic-white-matter-alterations-in-alzheimer-s-disease-using-combined-diffusivity-and-kurtosis-method
#14
Yuanyuan Chen, Miao Sha, Xin Zhao, Jianguo Ma, Hongyan Ni, Wei Gao, Dong Ming
Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) are important diffusion MRI techniques for detecting microstructure abnormities in diseases such as Alzheimer's. The advantages of DKI over DTI have been reported generally; however, the indistinct relationship between diffusivity and kurtosis has not been clearly revealed in clinical settings. In this study, we hypothesize that the combination of diffusivity and kurtosis in DKI improves the capacity of DKI to detect Alzheimer's disease compared with diffusivity or kurtosis alone...
April 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28448418/effects-of-b-value-on-quantification-of-rapid-diffusion-kurtosis-imaging-in-normal-and-acute-ischemic-brain-tissues
#15
Ming-Chung Chou, Cheng-Wen Ko, Yu-Hsien Chiu, Hsiao-Wen Chung, Ping-Hong Lai
PURPOSE: Diffusion kurtosis imaging (DKI) has been widely used to characterize brain tissue alterations. Diffusion-weighting factor or b value plays an important role in the measurement of rapid DKI and may have influential effects on them. The purpose of this study was to investigate the effects of b value on rapid DKI indices in normal and acute ischemic brain tissues. MATERIALS AND METHODS: This study enrolled 10 healthy subjects and 4 acute ischemic stroke patients...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28447147/diffusion-kurtosis-as-an-in-vivo-imaging-marker-of-early-radiation-induced-changes-in-radiation-induced-temporal-lobe-necrosis-in-nasopharyngeal-carcinoma-patients
#16
Lu Liyan, Wang Si, Wang Qian, Shao Yuhui, Wei Xiaoer, Li Yuehua, Li Wenbin
PURPOSE: Diffusion kurtosis imaging (DKI), an extension of the popular diffusion tensor imaging (DTI) model, has been applied in clinical studies of brain tissue changes. We explored the value of DKI for the early detection of radiation-induced changes in temporal lobe necrosis (TLN) after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS: A total of 400 patients with NPC were retrospectively enrolled; all participants underwent MRI scans 0-7 days before RT, at 4 weeks during RT, and 1 month after completing RT...
April 26, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28438531/altered-gray-and-white-matter-microstructure-in-cushing-s-disease-a-diffusional-kurtosis-imaging-study
#17
Hong Jiang, Na-Ying He, Yu-Hao Sun, Fang-Fang Jian, Liu-Guan Bian, Jian-Kang Shen, Fu-Hua Yan, Si-Jian Pan, Qing-Fang Sun
Exposure to chronic hypercortisolism has multiple adverse effects on brain biology in humans. Cushing's disease (CD) represents a unique and natural human model for examining the effects of hypercortisolism on the brain. This cross-sectional study used Diffusional Kurtosis Imaging (DKI) to investigate the microstructure alterations in both white matter (WM) and gray matter (GM) of CD patients and to determine the relationship of these changes with clinical characteristics. DKI images were obtained from 15 active CD patients...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28430583/non-invasive-prediction-of-the-tumor-growth-rate-using-advanced-diffusion-models-in-head-and-neck-squamous-cell-carcinoma-patients
#18
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Taisuke Harada, Yukie Shimizu, Khin Khin Tha, Kohsuke Kudo, Hiroki Shirato
We assessed parameters of advanced diffusion weighted imaging (DWI) models for the prediction of the tumor growth rate in 55 head and neck squamous cell carcinoma (HNSCC) patients. The DWI acquisition used single-shot spin-echo echo-planar imaging with 12 b-values (0-2000). We calculated 14 DWI parameters using mono-exponential, bi-exponential, tri-exponential, stretched exponential and diffusion kurtosis imaging models. We directly measured the tumor growth rate from two sets of different-date imaging data...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424656/empirical-comparison-of-diffusion-kurtosis-imaging-and-diffusion-basis-spectrum-imaging-using-the-same-acquisition-in-healthy-young-adults
#19
Sijia Wang, Daniel J Peterson, Yong Wang, Qing Wang, Thomas J Grabowski, Wenbin Li, Tara M Madhyastha
As diffusion tensor imaging gains widespread use, many researchers have been motivated to go beyond the tensor model and fit more complex diffusion models, to gain a more complete description of white matter microstructure and associated pathology. Two such models are diffusion kurtosis imaging (DKI) and diffusion basis spectrum imaging (DBSI). It is not clear which DKI parameters are most closely related to DBSI parameters, so in the interest of enabling comparisons between DKI and DBSI studies, we conducted an empirical survey of the interrelation of these models in 12 healthy volunteers using the same diffusion acquisition...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28417929/histogram-analysis-of-diffusion-weighted-imaging-at-3t-is-useful-for-prediction-of-lymphatic-metastatic-spread-proliferative-activity-and-cellularity-in-thyroid-cancer
#20
Stefan Schob, Hans Jonas Meyer, Julia Dieckow, Bhogal Pervinder, Nikolaos Pazaitis, Anne Kathrin Höhn, Nikita Garnov, Diana Horvath-Rizea, Karl-Titus Hoffmann, Alexey Surov
Pre-surgical diffusion weighted imaging (DWI) is increasingly important in the context of thyroid cancer for identification of the optimal treatment strategy. It has exemplarily been shown that DWI at 3T can distinguish undifferentiated from well-differentiated thyroid carcinoma, which has decisive implications for the magnitude of surgery. This study used DWI histogram analysis of whole tumor apparent diffusion coefficient (ADC) maps. The primary aim was to discriminate thyroid carcinomas which had already gained the capacity to metastasize lymphatically from those not yet being able to spread via the lymphatic system...
April 12, 2017: International Journal of Molecular Sciences
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