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diffusion kurtosis

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https://www.readbyqxmd.com/read/29352378/can-histogram-analysis-of-mr-images-predict-aggressiveness-in-pancreatic-neuroendocrine-tumors
#1
Riccardo De Robertis, Bogdan Maris, Nicolò Cardobi, Paolo Tinazzi Martini, Stefano Gobbo, Paola Capelli, Silvia Ortolani, Sara Cingarlini, Salvatore Paiella, Luca Landoni, Giovanni Butturini, Paolo Regi, Aldo Scarpa, Giampaolo Tortora, Mirko D'Onofrio
OBJECTIVES: To evaluate MRI derived whole-tumour histogram analysis parameters in predicting pancreatic neuroendocrine neoplasm (panNEN) grade and aggressiveness. METHODS: Pre-operative MR of 42 consecutive patients with panNEN >1 cm were retrospectively analysed. T1-/T2-weighted images and ADC maps were analysed. Histogram-derived parameters were compared to histopathological features using the Mann-Whitney U test. Diagnostic accuracy was assessed by ROC-AUC analysis; sensitivity and specificity were assessed for each histogram parameter...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29345431/the-effect-of-diuresis-on-extravascular-lung-water-and-pulmonary-function-in-acute-decompensated-heart-failure
#2
Steven C Chase, Caitlin C Fermoyle, Courtney M Wheatley, Jacob J Schaefer, Lyle J Olson, Bruce D Johnson
AIMS: The effect of extravascular lung water (EVLW) and relationship to functional status as a result of acute decompensated heart failure (ADHF) are not well understood. We sought to quantify changes in clinical variables, EVLW, airway anatomy, spirometry, and diffusing capacity for carbon monoxide before and after treatment for ADHF. METHODS AND RESULTS: Fifteen patients were recruited within 24 h of hospital admission. Spirometry, diffusing capacity for carbon monoxide, and surrogates of EVLW by computed tomography were measured and were then repeated within 24 h of discharge...
January 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29331362/multi-model-analysis-of-diffusion-weighted-imaging-of-normal-testes-at-3-0-t-preliminary-findings
#3
Xiangde Min, Zhaoyan Feng, Liang Wang, Jie Cai, Basen Li, Zan Ke, Peipei Zhang, Huijuan You, Xu Yan
RATIONALE AND OBJECTIVES: This study aimed to establish diffusion quantitative parameters (apparent diffusion coefficient [ADC], DDC, α, Dapp, and Kapp) in normal testes at 3.0 T. MATERIALS AND METHODS: Sixty-four healthy volunteers in two age groups (A: 10-39 years; B: ≥ 40 years) underwent diffusion-weighted imaging scanning at 3.0 T. ADC1000, ADC2000, ADC3000, DDC, α, Dapp, and Kapp were calculated using the mono-exponential, stretched-exponential, and kurtosis models...
January 10, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29306048/comparison-of-cumulant-expansion-and-q-space-imaging-estimates-for-diffusional-kurtosis-in-brain
#4
Vaibhav Mohanty, Emilie T McKinnon, Joseph A Helpern, Jens H Jensen
PURPOSE: To compare estimates for the diffusional kurtosis in brain as obtained from a cumulant expansion (CE) of the diffusion MRI (dMRI) signal and from q-space (QS) imaging. THEORY AND METHODS: For the CE estimates of the kurtosis, the CE was truncated to quadratic order in the b-value and fit to the dMRI signal for b-values from 0 up to 2000s/mm2. For the QS estimates, b-values ranging from 0 up to 10,000s/mm2 were used to determine the diffusion displacement probability density function (dPDF) via Stejskal's formula...
January 3, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29305126/assessing-diffusion-kurtosis-tensor-estimation-methods-using-a-digital-brain-phantom-derived-from-human-connectome-project-data
#5
Daniel V Olson, Volkan Arpinar, L Tugan Muftuler
PURPOSE: Diffusion kurtosis imaging (DKI) has gained popularity in recent years as an advanced diffusion-weighted MRI technique. This work aims to quantitatively compare the performance and accuracy of four DKI processing algorithms. For this purpose, a digital DKI brain phantom is developed. METHODS: Data from the Human Connectome Project database were used to generate a DKI digital phantom. In a Monte Carlo Rician noise simulation, four DKI processing algorithms were compared based on their mean square error, squared bias, and variance...
January 2, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29295753/differentiation-between-malignant-and-benign-breast-masses-combination-of-semi-quantitative-analysis-on-dce-mri-and-histogram-analysis-of-adc-maps
#6
H-L Liu, M Zong, H Wei, J-J Lou, S-Q Wang, Q-G Zou, H-B Shi, Y-N Jiang
AIM: To investigate the performance of combined semi-quantitative analysis on dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) and histogram analysis of diffusion-weighted imaging (DWI) for distinguishing malignant from benign breast masses. MATERIALS AND METHODS: This study included 178 patients with breast masses (benign:malignant=88:9) who underwent both DCE-MRI and DWI. The semi-quantitative parameters, derived from DCE-MRI, included maximum slope of increase (MSI), signal intensity slope (SIslope), initial percentage of enhancement (Einitial), percentage of peak enhancement (Epeak), early signal enhancement ratio (ESER), and second enhancement percentage (SEP)...
December 30, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29279166/characterization-of-testicular-germ-cell-tumors-whole-lesion-histogram-analysis-of-the-apparent-diffusion-coefficient-at-3t
#7
Xiangde Min, Zhaoyan Feng, Liang Wang, Jie Cai, Xu Yan, Basen Li, Zan Ke, Peipei Zhang, Huijuan You
PURPOSE: To assess the values of parameters derived from whole-lesion histograms of the apparent diffusion coefficient (ADC) at 3T for the characterization of testicular germ cell tumors (TGCTs). MATERIALS AND METHODS: A total of 24 men with TGCTs underwent 3T diffusion-weighted imaging. Fourteen tumors were pathologically confirmed as seminomas, and ten tumors were pathologically confirmed as nonseminomas. Whole-lesion histogram analysis of the ADC values was performed...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29277719/miniature-pig-model-of-human-adolescent-brain-white-matter-development
#8
Meghann C Ryan, Paul Sherman, Laura M Rowland, S Andrea Wijtenburg, Ashley Acheson, Els Fieremans, Jelle Veraart, Dmitry Novikov, L Elliot Hong, John Sladky, P Dana Peralta, Peter Kochunov, Stephen A McGuire
BACKGROUND: Neuroscience research in brain development and disorders can benefit from an in vivo animal model that portrays normal white matter (WM) development trajectories and has a sufficiently large cerebrum for imaging with human MRI scanners and protocols. NEW METHOD: Twelve three-month-old Sinclair™ miniature pigs (Sus scrofa domestica) were longitudinally evaluated during adolescent development using advanced diffusion weighted imaging (DWI) focused on cerebral WM...
December 22, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29275590/-parkinson-s-disease-diffusion-kurtosis-imaging-and-the-correlation-with-clinical-manifestations
#9
Y Q Sun, Q Zhang, Z Jiang, C Y Zhang, J W Zhang, H Chen, J K Shen
Objective: Using magnetic resonance diffusion kurtosis imaging (DKI) to evaluate the microstructure changes of deep brain nucleus in Parkinson's disease (PD) as well as the correlation with clinical manifestations. Methods: Thirty-two PD patients were recruited into this study. Twenty gender and age matched healthy subjects served as the control group. All participants underwent MRI examinations, including T(1)WI, T(2)WI, DWI, susceptibility weighted imaging (SWI) and DKI. The original DKI imaging data were processed offline to calculate two parametric maps, including mean kurtosis (MK) value and fractional anisotropy (FA) value...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29260882/histogram-analysis-of-apparent-diffusion-coefficient-maps-for-assessing-thymic-epithelial-tumors-correlation-with-world-health-organization-classification-and-clinical-staging
#10
Ling-Yan Kong, Wei Zhang, Yue Zhou, Hai Xu, Hai-Bin Shi, Qing Feng, Xiao-Quan Xu, Tong-Fu Yu
OBJECTIVE: To investigate the value of apparent diffusion coefficients (ADC) histogram analysis for assessing World Health Organization (WHO) pathological classification and Masaoka clinical stages of thymic epithelial tumors. METHODS: Thirty-seven patients with histologically confirmed thymic epithelial tumors were enrolled. ADC measurements were performed using hot-spot ROI (ADCHS-ROI) and histogram-based approach. ADC histogram parameters included mean ADC (ADCmean), median ADC (ADCmedian), 10 and 90 percentile of ADC (ADC10 and ADC90), kurtosis and skewness...
December 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29244222/diffusion-weighted-imaging-features-of-breast-tumours-and-the-surrounding-stroma-reflect-intrinsic-heterogeneous-characteristics-of-molecular-subtypes-in-breast-cancer
#11
Ming Fan, Ting He, Peng Zhang, Hu Cheng, Juan Zhang, Xin Gao, Lihua Li
Breast cancer heterogeneity is the main obstacle preventing the identification of patients with breast cancer with poor prognoses and treatment responses; however, such heterogeneity has not been well characterized. The purpose of this retrospective study was to reveal heterogeneous patterns in the apparent diffusion coefficient (ADC) signals in tumours and the surrounding stroma to predict molecular subtypes of breast cancer. A dataset of 126 patients with breast cancer, who underwent preoperative diffusion-weighted imaging (DWI) on a 3...
December 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29232021/investigation-of-diffusion-kurtosis-imaging-for-discriminating-tumors-from-inflammatory-lesions-after-treatment-for-bladder-cancer
#12
Fang Wang, Di Jin, Xiao-Lan Hua, Zi-Zhou Zhao, Lian-Ming Wu, Wei-Bo Chen, Guang-Yu Wu, Xiao-Xi Chen, Hai-Ge Chen
BACKGROUND: The bladder wall may thicken resulting from chronic inflammation after initial treatment (transurethral resection [TUR] or neoadjuvant chemotherapy), which may mimic the feature of recurrent or residual bladder tumors (RBT). Therefore, it is critical to discriminate RBT from benign lesions after initial treatment. PURPOSE: To investigate whether diffusion kurtosis imaging (DKI) could discriminate RBT from post-therapy bladder inflammatory lesions. STUDY TYPE: Retrospective...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29222677/diagnostic-evaluation-of-magnetization-transfer-and-diffusion-kurtosis-imaging-for-prostate-cancer-detection-in-a-re-biopsy-population
#13
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29221965/diffusion-kurtosis-imaging-of-a-human-nasopharyngeal-carcinoma-xenograft-model-initial-experience-with-pathological-correlation
#14
Jing Zhong, Peng Shi, Yunbin Chen, Rongfang Huang, Youping Xiao, Xiang Zheng, Dechun Zheng, Li Peng
PURPOSE: The aim of this study was to investigate the relationship between diffusion kurtosis imaging (DKI)-related parameters and pathological measures using human nasopharyngeal carcinoma (NPC) xenografts in a nude mouse model. MATERIALS AND METHODS: Twenty-six BALB/c-nu nude mice were divided into two groups that were injected with two different nasopharyngeal squamous cell carcinoma cell lines (CNE1 and CNE2). DK magnetic resonance (MR) imaging was performed on a 3...
December 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29221318/lung-densitometry-why-how-and-when
#15
REVIEW
Mario Mascalchi, Gianna Camiciottoli, Stefano Diciotti
Lung densitometry assesses with computed tomography (CT) the X-ray attenuation of the pulmonary tissue which reflects both the degree of inflation and the structural lung abnormalities implying decreased attenuation, as in emphysema and cystic diseases, or increased attenuation, as in fibrosis. Five reasons justify replacement with lung densitometry of semi-quantitative visual scales used to measure extent and severity of diffuse lung diseases: (I) improved reproducibility; (II) complete vs. discrete assessment of the lung tissue; (III) shorter computation times; (IV) better correlation with pathology quantification of pulmonary emphysema; (V) better or equal correlation with pulmonary function tests (PFT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29213008/the-relationship-between-neurite-density-measured-with-confocal-microscopy-in-a-cleared-mouse-brain-and-metrics-obtained-from-diffusion-tensor-and-diffusion-kurtosis-imaging
#16
Ryusuke Irie, Koji Kamagata, Aurelien Kerever, Ryo Ueda, Suguru Yokosawa, Yosuke Otake, Hisaaki Ochi, Hidekazu Yoshizawa, Ayato Hayashi, Kazuhiko Tagawa, Hitoshi Okazawa, Kohske Takahashi, Kanako Sato, Masaaki Hori, Eri Arikawa-Hirasawa, Shigeki Aoki
PURPOSE: Diffusional kurtosis imaging (DKI) enables sensitive measurement of tissue microstructure by quantifying the non-Gaussian diffusion of water. Although DKI is widely applied in many situations, histological correlation with DKI analysis is lacking. The purpose of this study was to determine the relationship between DKI metrics and neurite density measured using confocal microscopy of a cleared mouse brain. METHODS: One thy-1 yellow fluorescent protein 16 mouse was deeply anesthetized and perfusion fixation was performed...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29206593/glioma-grade-discrimination-with-mr-diffusion-kurtosis-imaging-a-meta-analysis-of-diagnostic-accuracy
#17
Anna Falk Delgado, Markus Nilsson, Danielle van Westen, Alberto Falk Delgado
Purpose To assess the diagnostic test accuracy and sources of heterogeneity for the discriminative potential of diffusion kurtosis imaging (DKI) to differentiate low-grade glioma (LGG) (World Health Organization [WHO] grade II) from high-grade glioma (HGG) (WHO grade III or IV). Materials and Methods The Cochrane Library, Embase, Medline, and the Web of Science Core Collection were systematically searched by two librarians. Retrieved hits were screened for inclusion and were evaluated with the revised tool for quality assessment for diagnostic accuracy studies (commonly known as QUADAS-2) by two researchers...
December 4, 2017: Radiology
https://www.readbyqxmd.com/read/29205392/toward-quantitative-fast-diffusion-kurtosis-imaging-with-b-values-chosen-in-consideration-of-signal-to-noise-ratio-and-model-fidelity
#18
Yen-Shu Kuo, Shun-Chung Yang, Hsiao-Wen Chung, Wen-Chau Wu
PURPOSE: Diffusion kurtosis (DK) imaging is a variant of conventional diffusion magnetic resonance (MR) imaging that allows assessment of non-Gaussian diffusion. Fast DK imaging expedites the procedure by decreasing both scan time (acquiring the minimally required number of b-values) and computation time (obviating least-square curve fitting). This study aimed to investigate the applicability of fast DK imaging for both cerebral gray matter and white matter as a quantitative method. METHODS: Seventeen healthy volunteers were recruited and each provided written informed consent before participation...
December 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/29198944/the-study-of-clear-cell-renal-cell-carcinoma-with-mr-diffusion-kurtosis-tensor-imaging-and-its-histopathologic-correlation
#19
Guangyu Wu, Zizhou Zhao, Qiuying Yao, Wen Kong, Jianrong Xu, Jin Zhang, Guiqin Liu, Yongming Dai
RATIONALE AND OBJECTIVES: The objective of this study was to compare the performance of diffusion kurtosis tensor imaging and diffusion-weighted imaging in the characterization of clear cell renal cell carcinoma (ccRCC) and their correlations with tumor histopathology. MATERIALS AND METHODS: Ninety-one patients diagnosed with ccRCC who underwent diffusion kurtosis tensor imaging were included in this study. Fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity, mean kurtosis (MK), radial kurtosis (Krad), and axial kurtosis (Kax) data were produced...
November 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29196269/diffusion-mri-and-mr-spectroscopy-reveal-microstructural-and-metabolic-brain-alterations-in-chronic-mild-stress-exposed-rats-a-cms-recovery-study
#20
Ahmad Raza Khan, Brian Hansen, Ove Wiborg, Christopher D Kroenke, Sune Nørhøj Jespersen
Chronic mild stress (CMS) induced depression elicits several debilitating symptoms and causes a significant economic burden on society. High variability in the symptomatology of depression poses substantial impediment to accurate diagnosis and therapy outcome. CMS exposure induces significant metabolic and microstructural alterations in the hippocampus (HP), prefrontal cortex (PFC), caudate-putamen (CP) and amygdala (AM), however, recovery from these maladaptive changes are limited and this may provide negative effects on the therapeutic treatment and management of depression...
November 28, 2017: NeuroImage
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