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diffusion kurtosis

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https://www.readbyqxmd.com/read/29165847/breast-lesion-characterization-using-whole-lesion-histogram-analysis-with-stretched-exponential-diffusion-model
#1
Chunling Liu, Kun Wang, Xiaodan Li, Jine Zhang, Jie Ding, Karl Spuhler, Timothy Duong, Changhong Liang, Chuan Huang
BACKGROUND: Diffusion-weighted imaging (DWI) has been studied in breast imaging and can provide more information about diffusion, perfusion and other physiological interests than standard pulse sequences. The stretched-exponential model has previously been shown to be more reliable than conventional DWI techniques, but different diagnostic sensitivities were found from study to study. PURPOSE: This work investigated the characteristics of whole-lesion histogram parameters derived from the stretched-exponential diffusion model for benign and malignant breast lesions, compared them with conventional apparent diffusion coefficient (ADC), and further determined which histogram metrics can be best used to differentiate malignant from benign lesions...
November 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29158186/diffusion-kurtosis-imaging-with-the-breath-hold-technique-for-staging-hepatic-fibrosis-a-preliminary-study
#2
Daisuke Yoshimaru, Toshiaki Miyati, Yuichi Suzuki, Yuhki Hamada, Nozomi Mogi, Ayumu Funaki, Ayumi Tabata, Atsuko Masunaga, Masahiko Shimada, Maki Tobari, Takayoshi Nishino
PURPOSE: To evaluate the potential of diffusion kurtosis imaging (DKI) analysis with the breath-hold technique to assess the stage or classify hepatic fibrosis. MATERIALS AND METHODS: Patients (n=67) suspected of having a disease of the hepatobiliary system examined by diffusion-weighted imaging (DWI) using a 3.0-T magnetic resonance imaging unit were enrolled in this study. To evaluate hepatic fibrosis, mean kurtosis, Mean apparent diffusion (MD) and apparent diffusion coefficient (ADC) values were compared between groups with varying fibrosis; F0-F1, F2-F3, and F4...
November 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29154897/identification-of-ghost-artifact-using-texture-analysis-in-pediatric-spinal-cord-diffusion-tensor-images
#3
Mahdi Alizadeh, Chris J Conklin, Devon M Middleton, Pallav Shah, Sona Saksena, Laura Krisa, Jürgen Finsterbusch, Scott H Faro, M J Mulcahey, Feroze B Mohamed
PURPOSE: Ghost artifacts are a major contributor to degradation of spinal cord diffusion tensor images. A multi-stage post-processing pipeline was designed, implemented and validated to automatically remove ghost artifacts arising from reduced field of view diffusion tensor imaging (DTI) of the pediatric spinal cord. METHOD: A total of 12 pediatric subjects including 7 healthy subjects (mean age=11.34years) with no evidence of spinal cord injury or pathology and 5 patients (mean age=10...
November 15, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29143940/histogram-analysis-of-diffusion-kurtosis-imaging-derived-maps-may-distinguish-between-low-and-high-grade-gliomas-before-surgery
#4
Xi-Xun Qi, Da-Fa Shi, Si-Xie Ren, Su-Ya Zhang, Long Li, Qing-Chang Li, Li-Ming Guan
OBJECTIVE: To investigate the value of histogram analysis of diffusion kurtosis imaging (DKI) maps in the evaluation of glioma grading. METHODS: A total of 39 glioma patients who underwent preoperative magnetic resonance imaging (MRI) were classified into low-grade (13 cases) and high-grade (26 cases) glioma groups. Parametric DKI maps were derived, and histogram metrics between low- and high-grade gliomas were analysed. The optimum diagnostic thresholds of the parameters, area under the receiver operating characteristic curve (AUC), sensitivity, and specificity were achieved using a receiver operating characteristic (ROC)...
November 16, 2017: European Radiology
https://www.readbyqxmd.com/read/29141363/-characteristics-of-high-resolution-diffusion-weighted-imaging-apparent-diffusion-coefficient-histogram-and-its-correlations-with-cancer-stages-in-patients-with-nasopharyngeal-carcinoma
#5
G J Wang, Y Wang, Y Ye, F Chen, Y T Lu, S L Li
Objective: To investigate the features of apparent diffusion coefficient (ADC) histogram parameters based on entire tumor volume data in high resolution diffusion weighted imaging of nasopharyngeal carcinoma (NPC) and to evaluate its correlations with cancer stages. Methods: This retrospective study included 154 cases of NPC patients[102 males and 52 females, mean age (48±11) years]who had received readout segmentation of long variable echo trains of MRI scan before radiation therapy. The area of tumor was delineated on each section of axial ADC maps to generate ADC histogram by using Image J...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29140606/mr-textural-analysis-on-t2-flair-images-for-the-prediction-of-true-oligodendroglioma-by-the-2016-who-genetic-classification
#6
Wenting Rui, Yan Ren, Yin Wang, Xinyi Gao, Xiao Xu, Zhenwei Yao
BACKGROUND: The genetic status of 1p/19q is important for differentiating oligodendroglioma, isocitrate-dehydrogenase (IDH)-mutant, and 1p/19q-codeleted from diffuse astrocytoma, IDH-mutant according to the 2016 World Health Organization (WHO) criteria. PURPOSE: To assess the value of magnetic resonance textural analysis (MRTA) on T2 fluid-attenuated inversion recovery (FLAIR) images for making a genetically integrated diagnosis of true oligodendroglioma by WHO guidelines...
November 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29117481/advanced-diffusion-weighted-imaging-modeling-for-prostate-cancer-characterization-correlation-with-quantitative-histopathologic-tumor-tissue-composition-a-hypothesis-generating-study
#7
Stefanie J Hectors, Sahar Semaan, Christopher Song, Sara Lewis, George K Haines, Ashutosh Tewari, Ardeshir R Rastinehad, Bachir Taouli
Purpose To correlate quantitative diffusion-weighted imaging (DWI) parameters derived from conventional monoexponential DWI, stretched exponential DWI, diffusion kurtosis imaging (DKI), and diffusion-tensor imaging (DTI) with quantitative histopathologic tumor tissue composition in prostate cancer in a preliminary hypothesis-generating study. Materials and Methods This retrospective institutional review board-approved study included 24 patients with prostate cancer (mean age, 63 years) who underwent magnetic resonance (MR) imaging, including high-b-value DWI and DTI at 3...
November 8, 2017: Radiology
https://www.readbyqxmd.com/read/29105178/is-there-evidence-for-more-than-two-diffusion-components-in-abdominal-organs-a-magnetic-resonance-imaging-study-in-healthy-volunteers
#8
Moritz C Wurnig, Manon Germann, Andreas Boss
The most commonly applied model for the description of diffusion-weighted imaging (DWI) data in perfused organs is bicompartmental intravoxel incoherent motion (IVIM) analysis. In this study, we assessed the ground truth of underlying diffusion components in healthy abdominal organs using an extensive DWI protocol and subsequent computation of apparent diffusion coefficient 'spectra', similar to the computation of previously described T2 relaxation spectra. Diffusion datasets of eight healthy subjects were acquired in a 3-T magnetic resonance scanner using 68 different b values during free breathing (equidistantly placed in the range 0-1005 s/mm(2) )...
November 3, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29103978/a-study-on-diffusion-and-kurtosis-features-of-cervical-cancer-based-on-non-gaussian-diffusion-weighted-model
#9
Panying Wang, Deepa Thapa, Guangyao Wu, Qunqi Sun, Hongbing Cai, Fei Tuo
OBJECTIVE: To explore the diffusion and kurtosis features of cervical cancer (CC) and study the feasibility of diffusion kurtosis imaging (DKI) based on the non-Gaussian diffusion-weighted model to differentiate the stage and grade of CC. METHODS: A total of 50 patients with pathologically confirmed CC were enrolled. MRI examinations including DKI (with 5b values 200, 500, 1000, 1500, and 2000smm(-2) were performed before any treatment. The apparent coefficient (Dapp) and the apparent kurtosis value (Kapp) were derived from the non-gaussian diffusion model, and the apparent diffusion coefficient (ADC) was derived from the Gaussian model...
November 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29095673/intravoxel-incoherent-motion-and-quantitative-non-gaussian-diffusion-mr-imaging-evaluation-of-the-diagnostic-and-prognostic-value-of-several-markers-of-malignant-and-benign-breast-lesions
#10
Mami Iima, Masako Kataoka, Shotaro Kanao, Natsuko Onishi, Makiko Kawai, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
Purpose To investigate the performance of integrated approaches that combined intravoxel incoherent motion (IVIM) and non-Gaussian diffusion parameters compared with the Breast Imaging and Reporting Data System (BI-RADS) to establish multiparameter thresholds scores or probabilities by using Bayesian analysis to distinguish malignant from benign breast lesions and their correlation with molecular prognostic factors. Materials and Methods Between May 2013 and March 2015, 411 patients were prospectively enrolled and 199 patients (allocated to training [n = 99] and validation [n = 100] sets) were included in this study...
November 2, 2017: Radiology
https://www.readbyqxmd.com/read/29095055/diffusion-mri-findings-in-patients-with-extensive-and-minimal-post-concussion-symptoms-after-mtbi-and-healthy-controls-a-cross-sectional-study
#11
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Anna Tietze, Charlotte Ulrikka Rask, Susanne Wulff Svendsen, Andreas Schröder, Mille Møller Thastum, Astrid Høeg Tuborgh, Oana-Veronica Frederiksen, Leif Østergaard, Simon Fristed Eskildsen, Brian Hansen, Sune Jespersen, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVES: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms. RESEARCH DESIGN: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group...
November 2, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29090485/fisher-information-and-cram%C3%A3-r-rao-lower-bound-for-experimental-design-in-parallel-imaging
#12
Mustapha Bouhrara, Richard G Spencer
PURPOSE: The Cramér-Rao lower bound (CRLB) is widely used in the design of magnetic resonance (MR) experiments for parameter estimation. Previous work has considered only Gaussian or Rician noise distributions in this calculation. However, the noise distribution for multi-coil acquisitions, such as in parallel imaging, obeys the noncentral χ-distribution under many circumstances. The purpose of this paper is to present the CRLB calculation for parameter estimation from multi-coil acquisitions...
November 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29075561/using-machine-learning-to-classify-temporal-lobe-epilepsy-based-on-diffusion-mri
#13
John Del Gaizo, Neda Mofrad, Jens H Jensen, David Clark, Russell Glenn, Joseph Helpern, Leonardo Bonilha
BACKGROUND: It is common for patients diagnosed with medial temporal lobe epilepsy (TLE) to have extrahippocampal damage. However, it is unclear whether microstructural extrahippocampal abnormalities are consistent enough to enable classification using diffusion MRI imaging. Therefore, we implemented a support vector machine (SVM)-based method to predict TLE from three different imaging modalities: mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA). While MD and FA can be calculated from traditional diffusion tensor imaging (DTI), MK requires diffusion kurtosis imaging (DKI)...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29063250/whole-tumour-diffusion-kurtosis-mr-imaging-histogram-analysis-of-rectal-adenocarcinoma-correlation-with-clinical-pathologic-prognostic-factors
#14
Yanfen Cui, Xiaotang Yang, Xiaosong Du, Zhizheng Zhuo, Lei Xin, Xintao Cheng
OBJECTIVE: To investigate potential relationships between diffusion kurtosis imaging (DKI)-derived parameters using whole-tumour volume histogram analysis and clinicopathological prognostic factors in patients with rectal adenocarcinoma. MATERIAL AND METHODS: 79 consecutive patients who underwent MRI examination with rectal adenocarcinoma were retrospectively evaluated. Parameters D, K and conventional ADC were measured using whole-tumour volume histogram analysis...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29050274/apparent-diffusion-coefficient-histogram-analysis-can-evaluate-radiation-induced-parotid-damage-and-predict-late-xerostomia-degree-in-nasopharyngeal-carcinoma
#15
Nan Zhou, Tingting Guo, Huanhuan Zheng, Xia Pan, Chen Chu, Xin Dou, Ming Li, Song Liu, Lijing Zhu, Baorui Liu, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
We investigated apparent diffusion coefficient (ADC) histogram analysis to evaluate radiation-induced parotid damage and predict xerostomia degrees in nasopharyngeal carcinoma (NPC) patients receiving radiotherapy. The imaging of bilateral parotid glands in NPC patients was conducted 2 weeks before radiotherapy (time point 1), one month after radiotherapy (time point 2), and four months after radiotherapy (time point 3). From time point 1 to 2, parotid volume, skewness, and kurtosis decreased (P < 0.001, = 0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046260/assessment-of-liver-regeneration-after-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-a-comparative-study-with-portal-vein-ligation
#16
Ruo-Fan Sheng, Li Yang, Kai-Pu Jin, He-Qing Wang, Hao Liu, Yuan Ji, Cai-Xia Fu, Meng-Su Zeng
BACKGROUND: To investigate the diagnostic value of diffusion kurtosis imaging (DKI) and diffusion-weighted imaging (DWI) in assessing liver regeneration after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) compared with portal vein ligation (PVL). METHODS: Thirty rats were divided into the ALPPS, PVL, and control groups. DKI and DWI were performed before and 7 days after surgery. Corrected apparent diffusion (D), kurtosis (K) and apparent diffusion coefficient (ADC) were calculated and compared, radiologic-pathologic correlations were evaluated...
October 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#17
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29044896/support-vector-machine-for-breast-cancer-classification-using-diffusion-weighted-mri-histogram-features-preliminary-study
#18
Igor Vidić, Liv Egnell, Neil P Jerome, Jose R Teruel, Torill E Sjøbakk, Agnes Østlie, Hans E Fjøsne, Tone F Bathen, Pål Erik Goa
BACKGROUND: Diffusion-weighted MRI (DWI) is currently one of the fastest developing MRI-based techniques in oncology. Histogram properties from model fitting of DWI are useful features for differentiation of lesions, and classification can potentially be improved by machine learning. PURPOSE: To evaluate classification of malignant and benign tumors and breast cancer subtypes using support vector machine (SVM). STUDY TYPE: Prospective. SUBJECTS: Fifty-one patients with benign (n = 23) and malignant (n = 28) breast tumors (26 ER+, whereof six were HER2+)...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29034282/differentiation-of-prostate-cancer-lesions-in-the-transition-zone-by-diffusion-weighted-mri
#19
Jie Bao, Ximing Wang, Chunhong Hu, Jianquan Hou, Fenglin Dong, Lingchuan Guo
OBJECTIVE: To differentiate prostate cancer lesions in transition zone by diffusion-weighted-MRI (DW-MRI). METHODS: Data from a total of 63 patients who underwent preoperative DWI (b of 0-1000 s/mm(2)) were prospectively collected and processed by a monoexponential (DWI) model and compared with a biexponential (IVIM) model for quantitation of apparent diffusion coefficients (ADCs), perfusion fraction f, diffusivity D and pseudo-diffusivity D*. Histogram analyses were performed by outlining entire-tumor regions of interest (ROIs)...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29031583/model-selection-for-high-b-value-diffusion-weighted-mri-of-the-prostate
#20
Yousef Mazaheri, Andreas M Hötker, Amita Shukla-Dave, Oguz Akin, Hedvig Hricak
PURPOSE: To assess the abilities of the standard mono-exponential (ME), bi-exponential (BE), diffusion kurtosis (DK) and stretched exponential (SE) models to characterize diffusion signal in malignant and prostatic tissues and determine which of the four models best characterizes these tissues on a per-voxel basis. MATERIALS AND METHODS: This institutional-review-board-approved, HIPAA-compliant, retrospective study included 55 patients (median age, 61years; range, 42-77years) with untreated, biopsy-proven PCa who underwent endorectal coil MRI at 3-Tesla, diffusion-weighted MRI acquired at eight b-values from 0 to 2000s/mm(2)...
October 12, 2017: Magnetic Resonance Imaging
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