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https://www.readbyqxmd.com/read/29241212/serum-magnesium-abnormality-and-influencing-factors-of-serum-magnesium-level-in-peritoneal-dialysis-patients-a-single-center-study-in-northern-china
#1
Shihming Tsai, Huiping Zhao, Bei Wu, Li Zuo, Mei Wang
BACKGROUND/AIMS: Both hypomagnesemia and hypermagnesemia have been associated with cardiovascular diseases, bone diseases, and mortality in dialysis patients. We aimed to investigate the prevalence of and influencing factors for abnormal serum Mg levels in patients on peritoneal dialysis (PD). METHODS: A cross-sectional study in Peking University People's Hospital recorded the demographic information, clinical characteristics, and laboratory data. Data were assessed and compared with the results from 2 other studies in China...
December 14, 2017: Blood Purification
https://www.readbyqxmd.com/read/29241183/leptin-suppresses-glutamate-induced-apoptosis-through-regulation-of-erk1-2-signaling-pathways-in-rat-primary-astrocytes
#2
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi
BACKGROUND/AIMS: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes. An anti-apoptosis effect of leptin in brain has recently been reported. However, the anti-apoptosis mechanism of leptin in the brain is unknown. METHODS: To investigate whether leptin exerts protective effects against glutamate-induced apoptosis in astrocytes, we performed cell viability assays and apoptosis assays using rat primary astrocytes...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29240820/age-related-nomograms-for-antral-follicle-count-and-anti-mullerian-hormone-for-subfertile-chinese-women-in-singapore
#3
See Ling Loy, Yin Bun Cheung, Marielle Valerie Fortier, Chiou Li Ong, Heng Hao Tan, Sadhana Nadarajah, Jerry Kok Yen Chan, Veronique Viardot-Foucault
BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman's ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women's and Children's Hospital, Singapore...
2017: PloS One
https://www.readbyqxmd.com/read/29240807/diversification-of-the-insulin-like-growth-factor-1-gene-in-mammals
#4
Peter Rotwein
Insulin-like growth factor 1 (IGF1), a small, secreted peptide growth factor, is involved in a variety of physiological and patho-physiological processes, including somatic growth, tissue repair, and metabolism of carbohydrates, proteins, and lipids. IGF1 gene expression appears to be controlled by several different signaling cascades in the few species in which it has been evaluated, with growth hormone playing a major role by activating a pathway involving the Stat5b transcription factor. Here, genes encoding IGF1 have been evaluated in 25 different mammalian species representing 15 different orders and ranging over ~180 million years of evolutionary diversification...
2017: PloS One
https://www.readbyqxmd.com/read/29240759/structural-and-dynamics-evidence-for-scaffold-asymmetric-flexibility-of-the-human-transthyretin-tetramer
#5
Giuseppe Zanotti, Francesca Vallese, Alberto Ferrari, Ilaria Menozzi, Tadeo E Saldaño, Paola Berto, Sebastian Fernandez-Alberti, Rodolfo Berni
The molecular symmetry of multimeric proteins is generally determined by using X-ray diffraction techniques, so that the basic question as to whether this symmetry is perfectly preserved for the same protein in solution remains open. In this work, human transthyretin (TTR), a homotetrameric plasma transport protein with two binding sites for the thyroid hormone thyroxine (T4), is considered as a case study. Based on the crystal structure of the TTR tetramer, a hypothetical D2 symmetry is inferred for the protein in solution, whose functional behavior reveals the presence of two markedly different Kd values for the two T4 binding sites...
2017: PloS One
https://www.readbyqxmd.com/read/29240722/g-protein-coupled-receptors-at-the-crossroad-between-physiologic-and-pathologic-angiogenesis-old-paradigms-and-emerging-concepts
#6
REVIEW
Ernestina M De Francesco, Federica Sotgia, Robert B Clarke, Michael P Lisanti, Marcello Maggiolini
G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses. As GPCRs can be activated by an extensive range of factors including hormones, neurotransmitters, phospholipids and other stimuli, their involvement in a plethora of physiological functions is not surprising. Aberrant GPCR signaling has been regarded as a major contributor to diverse pathologic conditions, such as inflammatory, cardiovascular and neoplastic diseases...
December 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29240719/pericardial-effusion-as-a-presenting-symptom-of-hashimoto-thyroiditis-a-case-report
#7
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Hashimoto thyroiditis (HT) is the most frequent cause of acquired hypothyroidism in paediatrics. HT is usually diagnosed in older children and adolescents, mainly in females and is rare in infants and toddlers with cardiac involvement, including pericardial effusion, that can be found in 10% to 30% of adult HT cases. In this paper, a child with HT and pericardial effusion as the most important sign of HT is described. Case presentation: A four-year-old male child suffering for a few months from recurrent abdominal pain sometimes associated with vomiting underwent an abdominal ultrasound scan outside the hospital...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29240692/acoustic-anomalies-and-fast-relaxation-dynamics-of-amorphous-progesterone-as-revealed-by-brillouin-light-scattering
#8
Tae Hyun Kim, Hyojong Yoo, Jae-Hyeon Ko
The amorphous state of pharmaceuticals has attracted much attention due to its high bioavailability and other advantages. The stability of the amorphous state in relation with the local molecular mobility is important from both fundamental and practical points of view. The acoustic properties of amorphous progesterone, one of the representative steroid hormones, were investigated by using a Brillouin inelastic light scattering technique. The Brillouin spectrum of the longitudinal acoustic mode exhibited distinct changes at the glass transition and the cold-crystallization temperatures...
December 14, 2017: Materials
https://www.readbyqxmd.com/read/29240652/interindividual-responses-of-appetite-to-acute-exercise-a-replicated-crossover-study
#9
Fernanda R Goltz, Alice E Thackray, James A King, James L Dorling, Greg Atkinson, David J Stensel
PURPOSE: Acute exercise transiently suppresses appetite, which coincides with alterations in appetite-regulatory hormone concentrations. Individual variability in these responses is suspected, but replicated trials are needed to quantify them robustly. We examined the reproducibility of appetite and appetite-regulatory hormone responses to acute exercise and quantified the individual differences in responses. METHODS: Fifteen healthy, recreationally-active men completed two control (60-min resting) and two exercise (60-min fasted treadmill running at 70% peak oxygen uptake) conditions in randomised sequences...
December 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29240543/stomping-out-hormone-sensitive-metastases-with-local-therapies-in-prostate-cancer
#10
Ryan M Phillips, Jonathan Hayman, Phuoc T Tran
No abstract text is available yet for this article.
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29240514/menopausal-asthma-much-ado-about-nothing-an-observational-study
#11
Katarzyna Bialek-Gosk, Marta Maskey-Warzechowska, Rafal Krenke, Marta Dabrowska, Magdalena Paplinska-Goryca, Patrycja Nejman-Gryz, Joanna Domagala-Kulawik, Tadeusz Przybylowski, Ryszarda Chazan
OBJECTIVE: Menopausal asthma is considered a distinct asthma phenotype. Our aim was to identify potential specific features of asthma in postmenopausal women in a cohort of Polish females. METHODS: Asthma severity and control, pulmonary function, exhaled nitric oxide (FENO), peripheral blood and induced sputum (IS) differential cell count were compared in three groups: women with premenopausal asthma (group 1), menopausal women with pre-existing asthma (group 2A) and menopausal women with asthma onset in the perimenopausal or menopausal period (group 2B)...
December 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29239836/determinants-of-weight-gain-during-adjuvant-endocrine-therapy-and-association-of-such-weight-gain-with-recurrence-in-long-term-breast-cancer-survivors
#12
Akshara Raghavendra, Arup K Sinha, Janeiro Valle, Yu Shen, Debu Tripathy, Carlos H Barcenas
BACKGROUND: Weight gain is a negative prognostic factor in breast cancer (BC) patients. The risk factors for weight gain during adjuvant endocrine therapy (ET) and the extent to which such weight gain is associated with disease recurrence remain unclear. PATIENTS AND METHODS: We retrospectively identified a cohort of women with a diagnosis of stage I-III, hormone receptor-positive, human epidermal growth factor receptor 2-negative BC from January 1997 to August 2008, who had received initial treatment at the MD Anderson Cancer Center, had completed 5 years of ET, and had remained free of locoregional or distant relapse or contralateral BC for ≥ 5 years after diagnosis...
November 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29239740/hyperthyroxinemia-is-positively-associated-with-prevalent-and-incident-type-2-diabetes-mellitus-in-two-population-based-samples-from-northeast-germany-and-denmark
#13
T Ittermann, S Schipf, M Dörr, B H Thuesen, T Jørgensen, H Völzke, M R P Markus
BACKGROUND AND AIMS: A potential causal relationship between thyroid function and type 2 diabetes mellitus is currently under debate, but the current state of research is limited. Our aim was to investigate the association of thyroid hormone levels with prevalent and incident type 2 diabetes mellitus (T2DM) in two representative studies. METHODS AND RESULTS: Analyses are based on data from the Study of Health in Pomerania (SHIP), a German population based cohort with 4308 individuals at baseline and 3300 individuals at a five-year follow-up, and from INTER99, a Danish population-based randomized controlled trial with 6784 individuals at baseline and 4516 individuals at the five-year-follow-up...
October 25, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29239604/nitrosoreductase-like-nanocatalyst-for-ultrasensitive-and-stable-biosensing
#14
Ponnusamy Nandhakumar, Byeongyoon Kim, Nam-Sihk Lee, Young Ho Yoon, Kwangyeol Lee, Haesik Yang
Enzyme-like nanocatalytic reactions developed for high signal amplification in biosensors are of limited use because of their low reaction rates and/or unwanted side reactions in aqueous electrolyte solutions containing dissolved O2. Herein, we report a nitrosoreductase-like catalytic reaction, employing 4-nitroso-1-naphthol, Pd nanoparticles, and H3N-BH3, which affords a high reaction rate and minimal side reactions, enabling its use in ultrasensitive electrochemical biosensors. 4-Nitroso-1-naphthol was chosen after five hydroxy-nitro(so)arene compounds were compared in terms of high signal and low background levels...
December 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29239351/association-of-serum-uric-acid-levels-with-osteoporosis-and-bone-turnover-markers-in-a-chinese-population
#15
Dan-Dan Yan, Jie Wang, Xu-Hong Hou, Yu-Qian Bao, Zhen-Lin Zhang, Cheng Hu, Wei-Ping Jia
Recent evidence shows that uric acid is protective against some neurological diseases, but can be detrimental in many metabolic and cardiovascular disorders. In this study, we examined the association between serum uric acid levels and bone metabolism in Chinese males and postmenopausal females. A total of 943 males and 4256 postmenopausal females were recruited in Shanghai. The levels of serum uric acid and bone turnover markers (BTMs) were detected along with other biochemical traits. In addition, the fat distribution was calculated through MRI and image analysis software, and bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29239315/the-role-of-general-anesthetics-and-the-mechanisms-of-hippocampal-and-extra-hippocampal-dysfunctions-in-the-genesis-of-postoperative-cognitive-dysfunction
#16
REVIEW
Marco Cascella, Sabrina Bimonte
Postoperative cognitive dysfunction (POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and amplifying a complex cascade involving the immuno-hormonal activation, the micro circle alterations, the hippocampal oxidative stress activation and, finally, an increased blood-brain barrier's permeability. While the role of anesthetics in the POCD's genesis in humans is debated, a huge number of preclinical studies have been conducted on the topic and many mechanisms have been proposed to explain the potential neurodegenerative effects of general anesthetics...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239216/protein-depalmitoylases
#17
Sang Joon Won, Melanie Cheung See Kit, Brent R Martin
Protein depalmitoylation describes the removal of thioester-linked long chain fatty acids from cysteine residues in proteins. For many S-palmitoylated proteins, this process is promoted by acyl protein thioesterase enzymes, which catalyze thioester hydrolysis to solubilize and displace substrate proteins from membranes. The closely related enzymes acyl protein thioesterase 1 (APT1; LYPLA1) and acyl protein thioesterase 2 (APT2; LYPLA2) were initially identified from biochemical assays as G protein depalmitoylases, yet later were shown to accept a number of S-palmitoylated protein and phospholipid substrates...
December 14, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29239033/what-s-new-in-pituitary-pathology
#18
REVIEW
Sylvia L Asa, Ozgur Mete
The increasing recognition of pituitary disorders and their impact on quality of life and longevity has made understanding of this small gland a subject of paramount importance. Pituitary pathology has seen many significant studies that indicate progress in identification and classification of pituitary lesions, as well as improved management strategies for patients. In this review, we outline six major areas of advances: (i) changes in terminology from 'adenoma' to 'pituitary neuroendocrine tumour'; (ii) reclassification of hormone-negative tumours based on transcription factor expression that defines lineage; (iii) updates in new pathogenetic mechanisms, including those that underlie rare lesions such as X-LAG and pituitary blastoma; (iv) clarification of hypophysitis due to immunotherapy, xanthomatous hypophysitis due to rupture of a Rathke's cleft cyst and IgG4 disease as the cause of inflammatory pseudotumour; (v) the consolidation of pituicytoma variants, including spindle cell oncocytoma and granular cell tumour based on thyroid transcription factor-1 (TTF-1) reactivity; and (vi) the pathogenetic mechanisms that distinguish papillary from adamantinomatous craniopharyngioma...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238946/papp-a2-a-new-key-regulator-of-growth
#19
Magdalena Banaszak-Ziemska, Marek Niedziela
Short stature is the main problem that paediatric endocrinologists have to grapple with. Endocrine disorders account for only 5% of patients with short stature, but this is still one of the most common causes of reports to the endocrine clinic and hospitalisation in the endocrine department. A properly functioning growth hormone/insulin-like growth factor (GH/IGF) axis is one of the most important factors in proper growth. A lot of genetic defects in this axis lead to syndromes marked by impaired growth, like Laron syndrome, muta-tions in the STAT5B, insulin-like growth factor 1 (IGF1), and insulin-like growth factor 1 receptor (IGF1R) and mutations in the acid labile subunit (ALS)...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29238923/endoscopic-therapy-and-curative-effect-in-pituitary-adenoma-patients-complicated-by-acromegalic-cardiomyopathy
#20
Heping Zhou, Zhengjiang Zha, Xiangdong Li, Xinsheng Chen, Jing Wang, Zhongzhou Su
The study aimed to retrospectively analyze the clinical characteristics of patients with pituitary adenomas complicated by acromegalic cardiomyopathy and to evaluate the effect of endoscopic surgery. Eighty-six pituitary adenoma patients complicated by acromegalic cardiomyopathy who were treated with endoscopic surgery in the First Affiliated Hospital of Soochow University from January 2010 to December 2016 were enrolled. We noted patient clinical characteristics and explored the relationships with surgical treatment...
December 13, 2017: Neurosurgical Review
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