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https://www.readbyqxmd.com/read/29679919/the-effect-of-growth-hormone-on-bioactive-igf-in-overweight-obese-women
#1
Laura E Dichtel, Mette Bjerre, Melanie Schorr, Miriam A Bredella, Anu V Gerweck, Brian M Russell, Jan Frystyk, Karen K Miller
OBJECTIVE: Overweight/obesity is characterized by decreased growth hormone (GH) secretion whereas circulating IGF-I levels are less severely reduced. Yet, the activity of the circulating IGF-system appears to be normal in overweight/obese subjects, as estimated by the ability of serum to activate the IGF-I receptor in vitro (bioactive IGF). We hypothesized that preservation of bioactive IGF in overweight/obese women is regulated by an insulin-mediated suppression of IGF-binding protein-1 (IGFBP-1) and IGFBP-2, and by suppression of IGFBP-3, mediated by low GH...
March 10, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29679911/the-effects-of-valproate-and-topiramate-use-on-serum-insulin-leptin-neuropeptide-y-and-ghrelin-levels-in-epileptic-children
#2
Nafiye Polat Çiçek, Tülay Kamaşak, Mine Serin, Aysenur Okten, Ahmet Alver, Ali Cansu
PURPOSE: Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described. The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group. METHOD: 48 patients (25 VPA, 23 TPM) aged between 6 and 15...
April 11, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29679775/influence-of-side-effects-on-early-therapy-persistence-with-letrozole-in-post-menopausal-patients-with-early-breast-cancer-results-of-the-prospective-evaluate-tm-study
#3
N Nabieva, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, M Popovic, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C C Hack, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
BACKGROUND: Endocrine treatment (ET) with an aromatase inhibitor (AI) is the treatment of choice in post-menopausal patients with hormone receptor-positive early breast cancer (EBC). However, adverse events (AEs) often lead to treatment discontinuation. This analysis aimed to identify side-effects that lead to patients failing to persist with letrozole treatment. PATIENTS AND METHODS: Post-menopausal hormone receptor-positive EBC patients starting ET with letrozole were enroled in EvAluate-TM, a non-interventional study...
April 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29679719/localization-of-cholecystokinin-in-the-zebrafish-retina-from-larval-to-adult-stage
#4
M C Guerrera, F Abbate, G Di Caro, G P Germanà, M Levanti, V Micale, G Montalbano, R Laurà, A Germanà, U Muglia
The peptide hormone cholecistokinin (CCK) plays a key role in the central and peripheral nervous system. It is known to be involved in the digestive physiology and in the regulation of food intake. Moreover, the CCK expression has also been detected in the retina of different vertebrates, including fish, although its biological activity in this tissue remains to be elucidated. In literature no data are yet available about the CCK-immunoreactivity in the zebrafish retina during development. Therefore, the aim of the study was to investigate the distribution of sulfated cholecystokinin octapeptide (CCK8-S) as a well preserved form during evolution in the zebrafish retina from 3days post hatching (dph) until adult stage, using immunohistochemistry in order to elucidate the potential role of this protein in the development and maintenance of normal retinal homeostasis...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679637/recent-stimulant-use-and-leukocyte-gene-expression-in-methamphetamine-users-with-treated-hiv-infection
#5
Adam W Carrico, Annesa Flentje, Kord Kober, Sulggi Lee, Peter Hunt, Elise D Riley, Steven Shoptaw, R N Elena Flowers, Samantha E Dilworth, Savita Pahwa, Bradley E Aouizerat
Stimulant use may accelerate HIV disease progression through biological and behavioral pathways. However, scant research with treated HIV-positive persons has examined stimulant-associated alterations in pathophysiologic processes relevant to HIV pathogenesis. In a sample of 55 HIV-positive, methamphetamine-using sexual minority men with a viral load less than 200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene expression in participants who had a urine sample that was reactive for stimulants (n = 27) as compared to those who tested non-reactive (n = 28)...
April 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29679619/a-global-perspective-on-carotenoids-metabolism-biotechnology-and-benefits-for-nutrition-and-health
#6
REVIEW
Manuel Rodriguez Concepcion, Javier Avalos, M Luisa Bonet, Albert Boronat, Lourdes Gomez-Gomez, Damaso Hornero-Mendez, M Carmen Limon, Antonio J Meléndez-Martínez, Begoña Olmedilla-Alonso, Andreu Palou, Joan Ribot, Maria J Rodrigo, Lorenzo Zacarias, Changfu Zhu
Carotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic organisms and some non-photosynthetic bacteria and fungi. With some notable exceptions, animals (including humans) do not produce carotenoids de novo but take them in their diets. In photosynthetic systems carotenoids are essential for photoprotection against excess light and contribute to light harvesting, but perhaps they are best known for their properties as natural pigments in the yellow to red range. Carotenoids can be associated to fatty acids, sugars, proteins, or other compounds that can change their physical and chemical properties and influence their biological roles...
April 18, 2018: Progress in Lipid Research
https://www.readbyqxmd.com/read/29679614/the-regulation-of-birdsong-by-testosterone-multiple-time-scales-and-multiple-sites-of-action
#7
REVIEW
Beau A Alward, Charlotte A Cornil, Jacques Balthazart, Gregory F Ball
Sex steroid hormones act during early development to shape the circuitry upon which these same hormones act in adulthood to control behavioral responses to various stimuli. The "organizational" vs. "activational" distinction was proposed to explain this temporal difference in hormone action. In both of these cases steroids were thought to act genomically over a time-scale of days to weeks. However, sex steroids can affect behavior over short (e.g., seconds or minutes) time-scales. Here, we discuss how testosterone controls birdsong via actions at different sites and over different time-scales, with an emphasis on this process in canaries (Serinus canaria)...
April 18, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29679598/sleep-in-women-across-the-lifespan
#8
REVIEW
Martino Pengo, Christine Won, Ghada Bourjeily
There are many ways in which women experience sleep differently than men. Women contend with distinct sleep challenges, respond differently to sleep disorders, sleep deprivation and deficiency, and face particular health outcomes as a result of poor sleep. Idiosyncrasies - including changes that occur with the biological life cycles of menstruation, pregnancy, and menopause- make the understanding of sleep in women an important topic to study. Each phase of a woman's life, from childhood to menopause, increases the risk of sleep disturbance in unique ways that may require distinct management...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679562/myotube-derived-factor-promotes-oligodendrocyte-precursor-cell-proliferation
#9
Akino Nakasone, Rieko Muramatsu, Yuki Kato, Yukio Kawahara, Toshihide Yamashita
Muscle cells secrete numerous molecules that function as endocrine hormones and regulate the functions of distant organs. Myelination in the central nervous system (CNS) is regulated by peripheral hormones. However, the effects of muscle-derived molecules on myelination have not been sufficiently analyzed. In this study, we show that muscle-releasing factors promote proliferation of oligodendrocyte precursor cells (OPCs), which is an element of myelination process. Supernatants of mouse myotube cultures stimulated bromodeoxyuridine (BrdU) incorporation into mouse OPCs...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679542/treatments-for-diabetes-mellitus-type-ii-new-perspectives-regarding-the-possible-role-of-calcium-and-camp-interaction
#10
REVIEW
Diego Soares Carvalho, Alexandre Aparecido de Almeida, Aurélio Ferreira Borges, Diego Vannucci Campos
Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29679493/ppars-and-pain
#11
REVIEW
Bright N Okine, Jessica C Gaspar, David P Finn
Chronic pain is a common cause of disability worldwide and remains a global health and socioeconomic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain, or associated with significant adverse side effects. The peroxisome proliferator-activated receptors (PPARs), a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679482/an-impurity-characterization-based-approach-for-the-rapid-development-of-integrated-downstream-purification-processes
#12
Steven M Timmick, Nicholas Vecchiarello, Chaz Goodwine, Laura E Crowell, Kerry R Love, J Christopher Love, Steven M Cramer
In this work, we describe a new approach for the characterization of process-related impurities along with an in silico tool to generate orthogonal, integrated downstream purification processes for biological products. A one-time characterization of process-related impurities from product expression in Pichia pastoris was first carried out using linear salt and pH gradients on a library of multimodal, salt-tolerant, and hydrophobic charge induction chromatographic resins. Reversed phase UPLC analysis of the fractions from these gradients was then used to generate large data sets of impurity profiles...
April 21, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29679481/prevalence-and-predictors-of-overweight-and-obesity-among-kenyan-women
#13
Rahma S Mkuu, Katrina Epnere, Muhammad Abdul Baker Chowdhury
INTRODUCTION: Overweight and obesity are associated with increased rates of chronic disease and death globally. In Kenya, the prevalence of overweight and obesity among women is high and may be growing. This study aimed to determine the national prevalence and predictors of overweight and obesity among women in Kenya. METHODS: We used cross-sectional data from the 2014 Kenya Demographic and Health Survey (KDHS). Data on body mass index for 13,048 women (aged 15-49 y) were analyzed by using multivariable logistic regression models...
April 19, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29679278/overexpression-of-modified-human-tr%C3%AE-1-suppresses-the-growth-of-hepatocarcinoma-sk-hep1-cells-in-vitro-and-in-xenograft-models
#14
Xiaoxiang Peng, Yuntao Zhou, Yanli Sun, Wei Song, Xiangying Meng, Chunling Zhao, Ronglan Zhao
Association studies suggest that TRβ1 functions as a tumor suppressor. Thyroid hormone receptors (TRs) mediate transcriptional responses through a highly conserved DNA-binding domain (DBD). We previously constructed an artificially modified human TRβ1 (m-TRβ1) via the introduction of a 108-bp exon sequence into the corresponding position of the wild-type human TRβ1 (TRβ1) DBD. Studies confirmed that m-TRβ1 was functional and could inhibit the proliferation of breast cancer MDA-MB-468 cells in vitro. To understand the role of m-TRβ1 in liver tumor development, we adopted a gain-of-function approach by stably expressing TRβ (m-TRβ1 and TRβ1) genes in a human hepatocarcinoma cell line, SK-hep1 (without endogenous TRβ), and then evaluated the effects of the expressed TRβ on cancer cell proliferation, migration, and tumor growth in cell-based studies and xenograft models...
April 20, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29679201/utilization-of-the-21-gene-recurrence-score-in-a-diverse-breast-cancer-patient-population-development-of-a-clinicopathologic-model-to-predict-high-risk-scores-and-response-to-neoadjuvant-chemotherapy
#15
Ko Un Park, Yalei Chen, Dhananjay Chitale, Sarah Choi, Haythem Ali, S David Nathanson, Jessica Bensenhaver, Erica Proctor, Lindsay Petersen, Randa Loutfi, Alyson Simonds, Marcia Kuklinski, Thomas Doyle, Vrushali Dabak, Kim Cole, Melissa Davis, Lisa Newman
INTRODUCTION: The 21-gene expression profile [Oncotype DX Recurrence Score (RS)] stratifies benefit from adjuvant chemotherapy in hormone receptor (HR)-positive, HER2/neu-negative, node-negative breast cancer. It is not routinely applied to predict neoadjuvant chemotherapy (NACT) response; data in diverse patient populations also are limited. We developed a statistical model based on standard clinicopathologic features to identify high-risk cases (RS > 30) and then evaluated ability of predicted high RS to predict for NACT downstaging...
April 20, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29678980/health-related-quality-of-life-in-asian-patients-with-breast-cancer-a-systematic-review
#16
Peh Joo Ho, Sofie A M Gernaat, Mikael Hartman, Helena M Verkooijen
OBJECTIVE: To summarise the evidence on determinants of health-related quality of life (HRQL) in Asian patients with breast cancer. DESIGN: Systematic review conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations and registered with PROSPERO (CRD42015032468). METHODS: According to the PRISMA guidelines, databases of MEDLINE (PubMed), Embase and PsycINFO were systematically searched using the following terms and synonyms: breast cancer, quality of life and Asia...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678923/eje-prize-2018-a-gut-feeling-about-glucagon
#17
Filip Krag Knop
Hyperglucagonaemia (in the fasting as well as in the postprandial state) is considered a core pathophysiological component of diabetes and to contribute substantially to the hyperglycaemic state of diabetes. Hyperglucagonaemia is usually viewed upon as a consequence of pancreatic alpha cell insensitivity to the glucagon-suppressive effects of glucose and insulin. Since we observed that the well-known hyperglucagonaemic response to oral glucose in patients with type 2 diabetes is exchanged by normal suppression of plasma glucagon levels following isoglycaemic intravenous glucose administration in these patients, we have been focusing on the gut and gut-derived factors as potential mediators of diabetic hyperglucagonaemia...
April 20, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29678908/the-lim-homeodomain-protein-isl1-mediates-the-function-of-tcf7l2-in-pancreatic-beta-cells
#18
Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong-Ping Feng, Cristina M Nostro, Tianru Jin
Pancreatic β-cell Tcf7l2 deletion or its functional knockdown suggested the essential role of this Wnt pathway effector in controlling insulin secretion, glucose homeostasis, and β-cell gene expression. As the LIM homeodomain protein Isl1 is a suggested Wnt pathway downstream target, we hypothesize that it mediates metabolic functions of Tcf7l2. We aimed to determine the role of Isl1 in mediating the function of Tcf7l2 and the incretin hormone GLP-1 in pancreatic β-cells. Effect of dominant negative TCF7L2 (TCF7L2DN) mediated Wnt pathway functional knockdown on Isl1 expression was determined in βTCFDN mouse islets and in the rat insulinoma cell line INS-1 832/13...
April 20, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29678867/effect-of-the-duodenal-jejunal-bypass-liner-on-glycemic-control-in-patients-with-type-2-diabetes-with-obesity-a-meta-analysis-with-secondary-analysis-on-weight-loss-and-hormonal-changes
#19
REVIEW
Pichamol Jirapinyo, Andrea V Haas, Christopher C Thompson
OBJECTIVE: Duodenal-jejunal bypass liner (DJBL) is an endoscopic device that may mimic small bowel mechanisms of Roux-en-Y gastric bypass (RYGB). Previous studies have demonstrated the efficacy of DJBL at inducing weight loss. We assessed the effect of DJBL on glycemic control in patients with type 2 diabetes (T2D) with obesity. RESEARCH DESIGN AND METHODS: Data sources included MEDLINE, EMBASE, and Web of Science through 1 July 2017. Included were published studies that assessed DJBL outcomes in obese T2D patients...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678847/diagnostic-value-of-vitamin-d-status-and-bone-turnover-markers-in-rheumatoid-arthritis-complicated-by-osteoporosis
#20
Li-Ming Tan, Ting-Ting Long, Xiao-Lin Guan, Si-Fan Wu, Wei Zheng, Hui-Ying Fu, Qiao-Hua Wang, Yi-Mei Meng, Yang Wu, Ting-Ting Zeng, Yong-Jian Tian, Jian-Lin Yu, Juan-Juan Chen, Hua Li, Li-Ping Cao
OBJECTIVE: To research the diagnostic performance of clinical potential bone turnover indexes in rheumatoid arthritis (RA) complicated with osteoporosis (OP). METHODS: This study involved 87 RA patients, 48 with OP, and 39 without OP, and 204 non-RA control patients, including those with systemic lupus erythematosus, ankylosing spondylitis, primary Sjogren's syndrome, systemic sclerosis, and healthy patients. The levels of 25-hydroxyvitamin D [25(OH)D], β-crosslaps (β-CROSSL), parathyroid hormone (PTH) were measured by electrochemiluminescence (ECLIA), and the level of bone alkaline phosphatase (BALP) was measured by lectin affinity method...
March 2018: Annals of Clinical and Laboratory Science
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