keyword
MENU ▼
Read by QxMD icon Read
search

Frankl

keyword
https://www.readbyqxmd.com/read/28094285/urinary-exosomes-contain-micrornas-capable-of-paracrine-modulation-of-tubular-transporters-in-kidney
#1
Tannia Gracia, Xiaonan Wang, Ya Su, Elizabeth E Norgett, Timothy L Williams, Pablo Moreno, Gos Micklem, Fiona E Karet Frankl
Exosomes derived from all nephron segments are present in human urine, where their functionality is incompletely understood. Most studies have focused on biomarker discovery rather than exosome function. Through sequencing we identified the miRNA repertoire of urinary exosomes from healthy volunteers; 276 mature miRNAs and 345 pre-miRNAs were identified (43%/7% of reads). Among the most abundant were members of the miR-10, miR-30 and let-7 families. Targets for the identified miRNAs were predicted using five different databases; genes encoding membrane transporters and their regulators were enriched, highlighting the possibility that these miRNAs could modulate key renal tubular functions in a paracrine manner...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28061861/oxidative-status-predicts-quality-in-human-mesenchymal-stem-cells
#2
Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel, Jivko Stoyanov
BACKGROUND: Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations to MSC use: (1) these therapies require large numbers of cells, and long-term expansion of MSC in vitro promotes replicative senescence; and (2) patient variability is a challenge for defining MSC quality standards for transplantation. This study aimed to determine whether low or high oxidative status of MSC correlate with changes in cell expansion and differentiation potentials...
January 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28052213/children-s-responses-to-sensory-stimuli-and-their-behavior-in-the-dental-office
#3
Sagit Nissan, Aviva Yochman, Sigalit Blumer, Johnny Kharouba, Benjamin Peretz
OBJECTIVES: To evaluate children's behavior during dental examinations, their reactions to various selected sensory stimuli and the association between them. STUDY DESIGN: Sixty-three children (28 boys and 35 girls) aged 5-12 years (mean age 7.9 ± 1.6 years) participated in the study. Their parents were asked to complete a questionnaire while in the dentist's waiting room. The dentists evaluated the children's behavior in the dental office using Frankl's behavioral scale and noted the children's reactions to the sensory stimuli of touch, noise, smell and backward tilting of the examination chair...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28045035/pdlim5-links-kidney-anion-exchanger-1-kae1-to-ilk-and-is-required-for-membrane-targeting-of-kae1
#4
Ya Su, Thomas F Hiemstra, Yahui Yan, Juan Li, Hannah I Karet, Lawrence Rosen, Pablo Moreno, Fiona E Karet Frankl
Anion exchanger 1 (AE1) mediates Cl(-)/HCO3(-) exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. AE1's C-terminal tail (AE1C) contains multiple potential membrane targeting/retention determinants, including a predicted PDZ binding motif, which are critical for its normal membrane residency. Here we identify PDLIM5 as a direct binding partner for AE1 in human kidney, via PDLIM5's PDZ domain and the PDZ binding motif in AE1C. Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex in which PDLIM5 provides a bridge between ILK and AE1C...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034540/reverse-shoulder-arthroplasty-in-patients-younger-than-55-years-2-to-12-year-follow-up
#5
Randall J Otto, Rachel E Clark, Mark A Frankle
BACKGROUND: This study reports the outcomes of reverse shoulder arthroplasty (RSA) in patients younger than 55 years with midterm to long-term follow-up. METHODS: Sixty-seven patients (average age, 47.9 years; range, 21-54 years) were identified who underwent RSA with an average 62.3 months of follow-up (24-144 months). There were 35 patients (group 1) who had a failed arthroplasty and 32 patients (group 2) who underwent primary RSA. Clinical outcomes included the American Shoulder and Elbow Surgeons (ASES) score, Simple Shoulder Test (SST) score, and range of motion...
December 26, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28003083/gitelman-syndrome-consensus-and-guidance-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#6
Anne Blanchard, Detlef Bockenhauer, Davide Bolignano, Lorenzo A Calò, Etienne Cosyns, Olivier Devuyst, David H Ellison, Fiona E Karet Frankl, Nine V A M Knoers, Martin Konrad, Shih-Hua Lin, Rosa Vargas-Poussou
Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is usually detected during adolescence or adulthood, either fortuitously or in association with mild or nonspecific symptoms or both. The disease is characterized by high phenotypic variability and a significant reduction in the quality of life, and it may be associated with severe manifestations...
January 2017: Kidney International
https://www.readbyqxmd.com/read/27928238/conscious-sedation-efficacy-of-0-3-and-0-5-mg-kg-oral-midazolam-for-three-to-six-year-old-uncooperative-children-undergoing-dental-treatment-a-clinical-trial
#7
Masoud Fallahinejad Ghajari, Ghassem Ansari, Leila Hasanbeygi, Shahnaz Shayeghi
OBJECTIVES: Midazolam with variable dosages has been used to induce sedation in pediatric dentistry. The aim of this study was to compare the efficacy of two dosages of oral midazolam for conscious sedation of children undergoing dental treatment. MATERIALS AND METHODS: In this randomized crossover double blind clinical trial, 20 healthy children (ASA I) aged three to six years with definitely negative Frankl behavioral rating scale were evaluated. Half of the children received 0...
March 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27915128/cholesterol-reducing-agents-inhibit-assembly-of-type-i-parainfluenza-viruses
#8
Shringkhala Bajimaya, Tsuyoshi Hayashi, Tünde Frankl, Peter Bryk, Brian Ward, Toru Takimoto
Many enveloped RNA viruses utilize lipid rafts for the assembly of progeny virions, but the role of cholesterol, a major component of rafts, on paramyxovirus budding and virion formation is controversial. In this study, we analyzed the effects of FDA-approved cholesterol-reducing agents, gemfibrozil and lovastatin, on raft formation and assembly of human parainfluenza virus type 1 (hPIV1) and Sendai virus (SeV). Treatment of the human airway epithelial A549 cells with the agents, especially when combined, significantly decreased production of infectious hPIV1 and SeV...
January 15, 2017: Virology
https://www.readbyqxmd.com/read/27903837/the-effect-of-army-vest-design-on-the-occurrence-of-stress-fractures-and-overuse-injuries-in-female-military-recruits
#9
Ezequiel Palmanovich, M Frankl, M Nyska, I Hetsroni, N Constantini, L Trejo, R Bechar, G Novak, Z Lankovsky, G Mann
INTRODUCTION: Stress fractures (SFs) occur when microdamage caused by repetitive mechanical load exceeds the biological load-bearing capacity of the bone. The study objective was to test whether a vest specifically designed and manufactured for female recruits, compared with the standard vest used on a regular basis by Border Police recruits, would reduce the incidence of SF in female Border Police recruits. Data based on reports of military personnel show that women are more likely to sustain SFs...
November 30, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27868388/in-vitro-lipolysis-is-associated-with-whole-body-lipid-oxidation-and-weight-gain-in-humans
#10
Joseph Frankl, Paolo Piaggi, James E Foley, Jonathan Krakoff, Susanne B Votruba
OBJECTIVE: To assess the association of adipocyte size with cellular lipolysis and between cellular lipolysis and whole-body lipid oxidation. This study also assessed the association between adipocyte size and cellular lipolysis with weight and fat mass gain. METHODS: Subjects had assessment of percent body fat (%fat) and adipose tissue biopsy for in vitro lipolysis (n = 325), and a subset of subjects had measurement of whole-body lipid oxidation (n = 112). A subset of subjects (n = 243) returned for repeated measurements of body weight and composition (mean follow-up 8...
January 2017: Obesity
https://www.readbyqxmd.com/read/27795998/a-classification-system-for-the-spread-of-polymethyl-methacrylate-in-vertebral-bodies-treated-with-vertebral-augmentation
#11
Joseph Frankl, Michael P Sakata, Gagandeep Choudhary, Seung Hur, Andrew Peterson, Charles T Hennemeyer
In this study, we develop a classification system for describing polymethyl methacrylate (PMMA) spread in vertebral bodies after kyphoplasty or vertebroplasty for vertebral compression fractures (VCFs) and for assessing whether PMMA spread varies between operators, VCF etiology, or vertebral level. Intraoperative fluoroscopic images of 198 vertebral levels were reviewed in 137 patients (women, 84; men, 53; mean age, 75.8 ± 12.5; and those with a diagnosis of osteoporosis, 63%) treated with kyphoplasty between January 01, 2015 and May 31, 2015 at a single center to create a 5-class descriptive system...
September 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/27759415/which-maternal-personality-traits-affect-child-behaviour-during-dental-treatment
#12
COMPARATIVE STUDY
A H Arpaci, B Işik, N Cura, B Kaplan, P Bozkurt
AIM: Maternal personality traits affect child dental behaviour and have a potential link with dental treatment methods. This study aims to evaluate which maternal personality traits affect child dental behaviour. MATERIALS AND METHODS: Research was carried out upon 60 children aged between 3-12 years, who had been admitted to our clinic for tooth extraction. All children were evaluated by means of the Frankl Behavior Scale (FBS): degrees I and II represent negative behaviours, while III and IV positive behaviour...
September 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27729085/chordoma-dedifferentiation-after-proton-beam-therapy-a-case-report-and-review-of-the-literature
#13
Joseph Frankl, Cassi Grotepas, Baldassare Stea, G Michael Lemole, Alexander Chiu, Rihan Khan
BACKGROUND: Chordoma is a rare invasive bone tumor that may occur anywhere along the neuraxis. A total of three primary histological varieties have been identified: conventional, chondroid, and dedifferentiated. CASE PRESENTATION: We report a case of an 8-year-old white girl who presented with conventional chordoma, was treated with surgical resection and mixed proton and photon beam therapy, and had a recurrence in the resection cavity 2.5 years later with dedifferentiated morphology...
October 12, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27637195/-the-problem-of-beginning-of-the-personal-being-in-the-anthropology-of-v-e-frankl
#14
Juan Fernando Sellés Dauder
In this paper we review the V. E. Frankl' conception of the 'person', which he understands as the superior part in man. This study consists of three parts: a) In the first we study 10 thesis that the father of logotherapy offers on the person, namely: 1st) the person is an individual; 2nd) whitaut possibility of sum; 3rd) is a new being; 4th) is spiritual; 5th) is existential; 6th) is the 'I' or the 'ego'; 7th) provides unity and wholeness; 8th) is dynamic; 9th) is able to transcend and to face herself; 10th) He is not understood by itself but from the point of view of transcendence...
May 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/27624646/kanner-asperger-and-frankl-a-third-man-at-the-genesis-of-the-autism-diagnosis
#15
John E Robison
Scholars have long speculated about how Kanner and Asperger's descriptions of autistic behavior appeared just 1 year apart in America and Austria even as World War II had severed communication between the two countries. Both conspiracy and serendipity have been alleged, but a simpler explanation has now emerged. Autistic knowledge crossed the Atlantic with Georg Frankl-a previously unrecognized "man in the middle" who followed his fiancé to America. The evidence presented here fills in many blanks and suggests both Kanner and Asperger benefited from Frankl's insight...
September 13, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27608043/antibiotic-treatment-in-end-of-life-cancer-patients-a-retrospective-observational-study-at-a-palliative-care-center-in-sweden
#16
Maria Helde-Frankling, Jenny Bergqvist, Peter Bergman, Linda Björkhem-Bergman
BACKGROUND: The aim of this study was to elucidate whether palliative cancer patients benefit from antibiotic treatment in the last two weeks of life when an infection is suspected. METHOD: We reviewed medical records from 160 deceased palliative cancer patients that had been included in previous studies on vitamin D and infections. Patients treated with antibiotics during the last two weeks of life were identified and net effects of treatment (symptom relief) and possible adverse events were extracted from medical records...
September 6, 2016: Cancers
https://www.readbyqxmd.com/read/27583111/morphologic-variability-of-the-shoulder-between-the-populations-of-north-american-and-east-asian
#17
Andres F Cabezas, Kristi Krebes, Michael M Hussey, Brandon G Santoni, Hyuong Sik Kim, Mark A Frankle, Joo Han Oh
BACKGROUND: The aim of this study was to determine if there were significant differences in glenohumeral joint morphology between North American and East Asian populations that may influence sizing and selection of shoulder arthroplasty systems. METHODS: Computed tomography reconstructions of 92 North American and 58 East Asian patients were used to perform 3-dimensional measurements. The proximal humeral position was normalized in all patients by aligning it with the scapular plane utilizing anatomic landmarks...
September 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27556551/evaluation-of-children-s-dental-anxiety-levels-at-a-kindergarten-and-at-a-dental-clinic
#18
Gulser Kilinç, Aynur Akay, Ece Eden, Nilgün Sevinç, Hülya Ellidokuz
This study evaluated the dental anxiety levels of preschool children at a kindergarten and at a dental clinic. The anxiety levels of ninety 4-6-year-old (4.99 ± 0.81) preschool children were evaluated according to pulse rates, the facial image scale (FIS), the Venham picture test (VPT), and the Frankl behavior rating scale. The children's mothers were asked to complete the state-trait anxiety inventory (STAI) forms 1 and 2 (STAI 2 and STAI 2). The sample t-test, Mann-Whitney U test, and Pearson's correlation test were used...
August 18, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27544989/-clinical-and-arthroscopic-findings-in-meniscal-injury-and-knee-instability-a-prospective-study
#19
Ezequiel Palmanovich, Amir Manor, Iftach Hetsroni, Niv Marom, Alexander Finsterbush, Uri Frankl, Joseph Lowe, Gideon Mann
INTRODUCTION: Medical history and physical examination are expected to provide the basic knowledge allowing diagnosis of a disease and thus enabling to plan the course of treatment. OBJECTIVE: This study aimed to examine this hypothesis by comparing pre-operative diagnosis of meniscal and anterior cruciate ligament (ACL) injuries to final surgical findings. MATERIAL AND METHODS: We prospectively compared the pre-surgical diagnosis to the arthroscopic findings in 753 arthroscopic procedures...
June 2016: Harefuah
https://www.readbyqxmd.com/read/27544988/-a-novel-gender-specific-vest-for-female-infantry-recruits-does-not-reduce-the-incidence-of-overuse-pain-syndromes-a-prospective-randomized-study-among-240-recruits
#20
RANDOMIZED CONTROLLED TRIAL
Ezequiel Palmanovich, Michal Frankl, Iftach Hetsroni, Meir Nyska, Niv Maron, Naama Constantin, Leonardo Trejo, Ron Bechar, Gideon Novak, Zeev Lankovsky, Gideon Mann
INTRODUCTION: Overuse pain syndromes constitute a troublesome byproduct of military infantry training, particularly in female fighters. These injuries result in lost days of training, pain and discomfort and can affect fitness and fighting abilities. We hypothesized that a gender specific vest would reduce the incidence of overuse pain syndromes in a population of female recruits during basic training. OBJECTIVE: The purpose of this study was therefore to examine the effect of a novel gender-specific combat vest on the incidence of lower back pain (LBP), anterior knee pain syndrome (AKPS), and plantar heel foot pain (PHFP) among female recruits...
June 2016: Harefuah
keyword
keyword
65726
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"