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https://www.readbyqxmd.com/read/28288299/comparison-between-positive-dental-images-and-neutral-images-in-managing-anticipatory-anxiety-of-children
#1
Dalia O Kamel, Nadia A Wahba, Dalia M Talaat
OBJECTIVE: To evaluate the impact of positive images versus neutral images on child behavior during dental treatment and their dental anxiety after dental treatment. STUDY DESIGN: Sixty, 4 to 6 year old healthy pediatric dental patients, indicated for pulpotomy and stainless steel crown restorations, were divided randomly into two equal groups. Group I (experimental group viewed positive dental images and group II (control group) viewed neutral cartoon images prior to treatment...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28245513/brain-translocator-protein-occupancy-by-ono-2952-in-healthy-adults-a-phase-1-pet-study-using-11-c-pbr28
#2
William G Frankle, Rajesh Narendran, Andrew T Wood, Fumitaka Suto, Michael L Himes, Michiyoshi Kobayashi, Tomoya Ohno, Akinori Yamauchi, Katsukuni Mitsui, Kevin Duffy, Bruce Mark
ONO-2952, a novel antagonist of translocator protein 18 kDa (TSPO), binds with high affinity to TSPO in rat brain and human tumor cell line membrane preparations. This study used the TSPO-specific PET radioligand [(11) C]PBR28 to confirm binding of ONO-2952 to brain TSPO in human subjects, and evaluate brain TSPO occupancy and its relationship with ONO-2952 plasma concentration. Sixteen healthy subjects received a single oral dose of 200, 60, 20, or 6 mg ONO-2952 (n=4 per dose). Two PET scans with [(11) C]PBR28 were conducted ≤7 days apart: at baseline and 24 hours after ONO-2952 administration...
February 28, 2017: Synapse
https://www.readbyqxmd.com/read/28169924/retrograde-maculopathy-in-patients-with-glaucoma
#3
Jacqueline Brazerol, Milko E Iliev, René Höhn, Stephan Fränkl, Hilary Grabe, Mathias Abegg
PURPOSE: Macular optical coherence tomography (OCT) analysis can be used for quantitative measures of optic nerve atrophy at a location far from the optic nerve head. This recently led to the finding of microcystic macular edema (MME), that is vacuolar inclusions in the macular inner nuclear layer, in some glaucoma patients. The involvement of individual retinal layers is yet unclear in glaucoma. In this study we systematically investigated glaucoma-induced changes in macular layers to evaluate whether glaucoma-associated damage extends beyond the macular ganglion cell layer...
February 6, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28162880/surgical-management-of-periprosthetic-shoulder-infections
#4
Geoffrey P Stone, Rachel E Clark, Kathleen C O'Brien, Lisa Vaccaro, Peter Simon, Adam J Lorenzetti, Brent C Stephens, Mark A Frankle
BACKGROUND: The treatment of periprosthetic joint infection is a difficult challenge in shoulder arthroplasty. This study investigated 1-stage modular component exchange vs. 1-stage complete removal and reimplantation (CRR) vs. 2-stage revision arthroplasty for periprosthetic joint infection. METHODS: Between January 1, 2004, and December 31, 2012, 79 patients received a component exchange (n = 15), CRR (n = 45), or a 2-stage (n = 19) revision for infection. A binary logistic regression analysis was performed to determine factors presenting the greatest risk of reinfection...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28158280/proximate-mechanism-of-behavioral-manipulation-of-an-orb-weaver-spider-host-by-a-parasitoid-wasp
#5
Thiago Gechel Kloss, Marcelo Oliveira Gonzaga, Leandro Licursi de Oliveira, Carlos Frankl Sperber
Some ichneumonid wasps induce modifications in the web building behavior of their spider hosts to produce resistant "cocoon" webs. These structures hold and protect the wasp's cocoon during pupa development. The mechanism responsible for host manipulation probably involves the inoculation of psychotropic chemicals by the parasitoid larva during a specific developmental period. Recent studies indicate that some spiders build cocoon webs similar to those normally built immediately before ecdysis, suggesting that this substance might be a molting hormone or a precursor chemical of this hormone...
2017: PloS One
https://www.readbyqxmd.com/read/28150886/morphometry-of-the-human-clavicle-and-intramedullary-canal-a-3d-geometry-based-quantification
#6
Jazmine R Aira, Peter Simon, Sergio Gutiérrez, Brandon G Santoni, Mark A Frankle
Midshaft clavicle fractures are a very common occurrence. The current treatment of choice involves internal fixation with superior or anterior clavicle plating, however their clinical success and particularly patient satisfaction are decreasing. The implementation of intramedullary devices is on the rise, but data describing the intramedullary canal parameters are lacking. The aim of this study is to quantify the geometry of the clavicle and its intramedullary canal, and to evaluate the effect of gender and anatomical side...
February 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28139387/the-influence-of-patient-and-surgeon-specific-factors-on-operative-duration-and-early-postoperative-outcomes-in-shoulder-arthroplasty
#7
Jonathan C Clark, Peter Simon, Rachel E Clark, Kaitlyn N Christmas, Jesse W Allert, Jonathan J Streit, Mark A Mighell, Alfred Hess, Jeffrey Stone, Mark A Frankle
BACKGROUND: Increased operative duration has been shown to have demonstrable effects on the outcomes and complications in multiple areas of orthopedic surgery. We sought to determine if patient- and surgeon-specific factors correlated to operative duration in shoulder arthroplasty. Our hypothesis was that increased surgeon and trainee volume would decrease operative times and that more complex pathology would increase operative duration. METHODS: A retrospective review of primary and revision total and reverse shoulder arthroplasties performed at a single institution from 2012 through 2015 was performed evaluating the correlation between specific patient and surgeon factors and operative duration...
January 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28129381/comparative-cytogenetics-between-two-important-songbird-models-the-zebra-finch-and-the-canary
#8
Michelly da Silva Dos Santos, Rafael Kretschmer, Carolina Frankl-Vilches, Antje Bakker, Manfred Gahr, Patricia C M O Brien, Malcolm A Ferguson-Smith, Edivaldo H C de Oliveira
Songbird species (order Passeriformes, suborder Oscines) are important models in various experimental fields spanning behavioural genomics to neurobiology. Although the genomes of some songbird species were sequenced recently, the chromosomal organization of these species is mostly unknown. Here we focused on the two most studied songbird species in neuroscience, the zebra finch (Taeniopygia guttata) and the canary (Serinus canaria). In order to clarify these issues and also to integrate chromosome data with their assembled genomes, we used classical and molecular cytogenetics in both zebra finch and canary to define their chromosomal homology, localization of heterochromatic blocks and distribution of rDNA clusters...
2017: PloS One
https://www.readbyqxmd.com/read/28128664/temperament-as-a-predictor-of-nitrous-oxide-inhalation-sedation-success
#9
Travis M Nelson, Thomas M Griffith, Katherine J Lane, Sarat Thikkurissy, JoAnna M Scott
Little is known about implications of temperament for children who receive nitrous oxide inhalation sedation (N2O/O2) for dental care. The aim of this study was to investigate whether child temperament is associated with success in N2O/O2. Child-caregiver dyads were enrolled from patients aged 36-95 months receiving dental care with N2O/O2 at a university-based pediatric dental clinic. To assess child temperament, 48 caregivers completed the Children's Behavior Questionnaire Short Form. Patient behavior was abstracted from Frankl scores recorded in the patient's chart...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/28094285/urinary-exosomes-contain-micrornas-capable-of-paracrine-modulation-of-tubular-transporters-in-kidney
#10
Tannia Gracia, Xiaonan Wang, Ya Su, Elizabeth E Norgett, Timothy L Williams, Pablo Moreno, Gos Micklem, Fiona E Karet Frankl
Exosomes derived from all nephron segments are present in human urine, where their functionality is incompletely understood. Most studies have focused on biomarker discovery rather than exosome function. Through sequencing we identified the miRNA repertoire of urinary exosomes from healthy volunteers; 276 mature miRNAs and 345 pre-miRNAs were identified (43%/7% of reads). Among the most abundant were members of the miR-10, miR-30 and let-7 families. Targets for the identified miRNAs were predicted using five different databases; genes encoding membrane transporters and their regulators were enriched, highlighting the possibility that these miRNAs could modulate key renal tubular functions in a paracrine manner...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28061861/oxidative-status-predicts-quality-in-human-mesenchymal-stem-cells
#11
Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel, Jivko Stoyanov
BACKGROUND: Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations to MSC use: (1) these therapies require large numbers of cells, and long-term expansion of MSC in vitro promotes replicative senescence; and (2) patient variability is a challenge for defining MSC quality standards for transplantation. This study aimed to determine whether low or high oxidative status of MSC correlate with changes in cell expansion and differentiation potentials...
January 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28052213/children-s-responses-to-sensory-stimuli-and-their-behavior-in-the-dental-office
#12
Sagit Nissan, Aviva Yochman, Sigalit Blumer, Johnny Kharouba, Benjamin Peretz
OBJECTIVES: To evaluate children's behavior during dental examinations, their reactions to various selected sensory stimuli and the association between them. STUDY DESIGN: Sixty-three children (28 boys and 35 girls) aged 5-12 years (mean age 7.9 ± 1.6 years) participated in the study. Their parents were asked to complete a questionnaire while in the dentist's waiting room. The dentists evaluated the children's behavior in the dental office using Frankl's behavioral scale and noted the children's reactions to the sensory stimuli of touch, noise, smell and backward tilting of the examination chair...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28045035/pdlim5-links-kidney-anion-exchanger-1-kae1-to-ilk-and-is-required-for-membrane-targeting-of-kae1
#13
Ya Su, Thomas F Hiemstra, Yahui Yan, Juan Li, Hannah I Karet, Lawrence Rosen, Pablo Moreno, Fiona E Karet Frankl
Anion exchanger 1 (AE1) mediates Cl(-)/HCO3(-) exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. AE1's C-terminal tail (AE1C) contains multiple potential membrane targeting/retention determinants, including a predicted PDZ binding motif, which are critical for its normal membrane residency. Here we identify PDLIM5 as a direct binding partner for AE1 in human kidney, via PDLIM5's PDZ domain and the PDZ binding motif in AE1C. Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex in which PDLIM5 provides a bridge between ILK and AE1C...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034540/reverse-shoulder-arthroplasty-in-patients-younger-than-55-years-2-to-12-year-follow-up
#14
Randall J Otto, Rachel E Clark, Mark A Frankle
BACKGROUND: This study reports the outcomes of reverse shoulder arthroplasty (RSA) in patients younger than 55 years with midterm to long-term follow-up. METHODS: Sixty-seven patients (average age, 47.9 years; range, 21-54 years) were identified who underwent RSA with an average 62.3 months of follow-up (24-144 months). There were 35 patients (group 1) who had a failed arthroplasty and 32 patients (group 2) who underwent primary RSA. Clinical outcomes included the American Shoulder and Elbow Surgeons (ASES) score, Simple Shoulder Test (SST) score, and range of motion...
December 26, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28003083/gitelman-syndrome-consensus-and-guidance-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#15
Anne Blanchard, Detlef Bockenhauer, Davide Bolignano, Lorenzo A Calò, Etienne Cosyns, Olivier Devuyst, David H Ellison, Fiona E Karet Frankl, Nine V A M Knoers, Martin Konrad, Shih-Hua Lin, Rosa Vargas-Poussou
Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is usually detected during adolescence or adulthood, either fortuitously or in association with mild or nonspecific symptoms or both. The disease is characterized by high phenotypic variability and a significant reduction in the quality of life, and it may be associated with severe manifestations...
January 2017: Kidney International
https://www.readbyqxmd.com/read/27928238/conscious-sedation-efficacy-of-0-3-and-0-5-mg-kg-oral-midazolam-for-three-to-six-year-old-uncooperative-children-undergoing-dental-treatment-a-clinical-trial
#16
Masoud Fallahinejad Ghajari, Ghassem Ansari, Leila Hasanbeygi, Shahnaz Shayeghi
OBJECTIVES: Midazolam with variable dosages has been used to induce sedation in pediatric dentistry. The aim of this study was to compare the efficacy of two dosages of oral midazolam for conscious sedation of children undergoing dental treatment. MATERIALS AND METHODS: In this randomized crossover double blind clinical trial, 20 healthy children (ASA I) aged three to six years with definitely negative Frankl behavioral rating scale were evaluated. Half of the children received 0...
March 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27915128/cholesterol-reducing-agents-inhibit-assembly-of-type-i-parainfluenza-viruses
#17
Shringkhala Bajimaya, Tsuyoshi Hayashi, Tünde Frankl, Peter Bryk, Brian Ward, Toru Takimoto
Many enveloped RNA viruses utilize lipid rafts for the assembly of progeny virions, but the role of cholesterol, a major component of rafts, on paramyxovirus budding and virion formation is controversial. In this study, we analyzed the effects of FDA-approved cholesterol-reducing agents, gemfibrozil and lovastatin, on raft formation and assembly of human parainfluenza virus type 1 (hPIV1) and Sendai virus (SeV). Treatment of the human airway epithelial A549 cells with the agents, especially when combined, significantly decreased production of infectious hPIV1 and SeV...
January 15, 2017: Virology
https://www.readbyqxmd.com/read/27903837/the-effect-of-army-vest-design-on-the-occurrence-of-stress-fractures-and-overuse-injuries-in-female-military-recruits
#18
Ezequiel Palmanovich, M Frankl, M Nyska, I Hetsroni, N Constantini, L Trejo, R Bechar, G Novak, Z Lankovsky, G Mann
INTRODUCTION: Stress fractures (SFs) occur when microdamage caused by repetitive mechanical load exceeds the biological load-bearing capacity of the bone. The study objective was to test whether a vest specifically designed and manufactured for female recruits, compared with the standard vest used on a regular basis by Border Police recruits, would reduce the incidence of SF in female Border Police recruits. Data based on reports of military personnel show that women are more likely to sustain SFs...
November 30, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27868388/in-vitro-lipolysis-is-associated-with-whole-body-lipid-oxidation-and-weight-gain-in-humans
#19
Joseph Frankl, Paolo Piaggi, James E Foley, Jonathan Krakoff, Susanne B Votruba
OBJECTIVE: To assess the association of adipocyte size with cellular lipolysis and between cellular lipolysis and whole-body lipid oxidation. This study also assessed the association between adipocyte size and cellular lipolysis with weight and fat mass gain. METHODS: Subjects had assessment of percent body fat (%fat) and adipose tissue biopsy for in vitro lipolysis (n = 325), and a subset of subjects had measurement of whole-body lipid oxidation (n = 112). A subset of subjects (n = 243) returned for repeated measurements of body weight and composition (mean follow-up 8...
January 2017: Obesity
https://www.readbyqxmd.com/read/27795998/a-classification-system-for-the-spread-of-polymethyl-methacrylate-in-vertebral-bodies-treated-with-vertebral-augmentation
#20
Joseph Frankl, Michael P Sakata, Gagandeep Choudhary, Seung Hur, Andrew Peterson, Charles T Hennemeyer
In this study, we develop a classification system for describing polymethyl methacrylate (PMMA) spread in vertebral bodies after kyphoplasty or vertebroplasty for vertebral compression fractures (VCFs) and for assessing whether PMMA spread varies between operators, VCF etiology, or vertebral level. Intraoperative fluoroscopic images of 198 vertebral levels were reviewed in 137 patients (women, 84; men, 53; mean age, 75.8 ± 12.5; and those with a diagnosis of osteoporosis, 63%) treated with kyphoplasty between January 01, 2015 and May 31, 2015 at a single center to create a 5-class descriptive system...
September 2016: Tomography: a Journal for Imaging Research
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