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https://www.readbyqxmd.com/read/28514491/3d-image-based-morphometric-analysis-of-the-scapular-neck-length-in-subjects-undergoing-reverse-shoulder-arthroplasty
#1
P Simon, M Diaz, M Cusick, B Santoni, M Frankle
INTRODUCTION: Scapular notching after RSA may, in part, be related to a patient's scapular morphology. The purpose of this study was to develop a novel 3D measurement technique to describe infraglenoid tubercle morphometry. We hypothesize that the parameters describing infraglenoid tubercle would be normally distributed and would correlate with individual's demographics and glenoid morphometry. MATERIALS AND METHODS: A group of 110 subjects treated with RSA were evaluated...
May 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28504808/outcome-of-reverse-shoulder-arthroplasty-for-patients-with-parkinson-s-disease-a-matched-cohort-study
#2
Michael C Cusick, Randall J Otto, Rachel E Clark, Mark A Frankle
Parkinson's disease (PD) is a progressive neurologic disorder that affects the musculoskeletal system. Currently, the use of reverse shoulder arthroplasty (RSA) for patients with PD has not been adequately studied. The authors sought to determine if RSA provided similar functional outcomes for patients with PD compared with a matched cohort of patients without PD. Between 2004 and 2011, 10 patients with PD (4 men, 6 women) underwent RSA. Patients with PD were matched to patients without PD at a 1:4 ratio based on age (average, 76 years; range, 63-85 years), sex (16 men, 24 women), preoperative diagnosis, and length of follow-up (average, 43 months; range, 24-128 months)...
May 15, 2017: Orthopedics
https://www.readbyqxmd.com/read/28492191/prevalence-of-dental-fear-and-its-causes-using-three-measurement-scales-among-children-in-new-delhi
#3
Anju Singh Rajwar, Mridula Goswami
INTRODUCTION: There is a great need for identifying fearful children, who often present problems in patient management, thus affecting the quality of dental care rendered to them. This study is unique in the way that dental fear was assessed through three fear scales as research has suggested the use of more than one scale because each scale has its own restrictions and is open to criticism. AIM: The aim of this study was to evaluate dental fear and anxiety (DFA) among children aged 3-14 years using three fear measurement scales...
April 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28492190/decreased-sleep-in-children-and-their-behavioral-problems-in-dental-operatory
#4
Vinaya Kumar Kulkarni, Ami Kandya, Sakshi Arora, Garima Singh
PURPOSE: This study was conducted to examine the contribution of inadequate sleep and its associated factors, on behavior and cooperation of children in the dental operatory. MATERIALS AND METHODS: A cross-sectional study was conducted on 100 healthy children at the time of their initial visit to the dental hospital, ranging from preschoolers to adolescents. Data acquisition was done by a questionnaire. Interview with the accompanying person was done to ask about the sleep duration, naps, and sleep habits of the child...
April 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28384187/target-localization-of-3d-versus-4d-cone-beam-computed-tomography-in-lipiodol-guided-stereotactic-radiotherapy-of-hepatocellular-carcinomas
#5
Mark Chan, Chi Leung Chiang, Venus Lee, Steven Cheung, Ronnie Leung, Matthew Wong, Frankle Lee, Oliver Blanck
BACKGROUND: Aim of this study was to comparatively evaluate the accuracy of respiration-correlated (4D) and uncorrelated (3D) cone beam computed tomography (CBCT) in localizing lipiodolized hepatocellular carcinomas during stereotactic body radiotherapy (SBRT). METHODS: 4D-CBCT scans of eighteen HCCs were acquired during free-breathing SBRT following trans-arterial chemo-embolization (TACE) with lipiodol. Approximately 1320 x-ray projections per 4D-CBCT were collected and phase-sorted into ten bins...
2017: PloS One
https://www.readbyqxmd.com/read/28377650/identifying-dental-anxiety-in-children-s-drawings-and-correlating-it-with-frankl-s-behavior-rating-scale
#6
Jyoti Mathur, Amish Diwanji, Bhumi Sarvaiya, Dipal Sharma
AIM: To develop a simple method to assess the level of anxiety by using children's drawings and correlating them with Frankl's behavior rating scale. MATERIALS AND METHODS: A total of 178 patients aged of 3 to 14 years were handed out two-page forms which contained three sections on coloring and drawing, along with general information, and Frankl's behavior rating scale for the visit. The three types of drawing exercises given to the patients were geometric copy drawings, coloring a nonthreatening figure, and an empty sheet for freehand drawing...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28288299/comparison-between-positive-dental-images-and-neutral-images-in-managing-anticipatory-anxiety-of-children
#7
Dalia O Kamel, Nadia A Wahba, Dalia M Talaat
OBJECTIVE: To evaluate the impact of positive images versus neutral images on child behavior during dental treatment and their dental anxiety after dental treatment. STUDY DESIGN: Sixty, 4 to 6 year old healthy pediatric dental patients, indicated for pulpotomy and stainless steel crown restorations, were divided randomly into two equal groups. Group I (experimental group viewed positive dental images and group II (control group) viewed neutral cartoon images prior to treatment...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28245513/brain-translocator-protein-occupancy-by-ono-2952-in-healthy-adults-a-phase-1-pet-study-using-11-c-pbr28
#8
W Gordon Frankle, Rajesh Narendran, Andrew T Wood, Fumitaka Suto, Michael L Himes, Michiyoshi Kobayashi, Tomoya Ohno, Akinori Yamauchi, Katsukuni Mitsui, Kevin Duffy, Mark Bruce
ONO-2952, a novel antagonist of translocator protein 18 kDa (TSPO), binds with high affinity to TSPO in rat brain and human tumor cell line membrane preparations. This study used the TSPO-specific PET radioligand [(11) C]PBR28 to confirm binding of ONO-2952 to brain TSPO in human subjects, and evaluate brain TSPO occupancy and its relationship with ONO-2952 plasma concentration. Sixteen healthy subjects received a single oral dose of 200, 60, 20, or 6 mg ONO-2952 (n = 4 per dose). Two PET scans with [(11) C]PBR28 were conducted ≤7 days apart: at baseline and 24 h after ONO-2952 administration...
July 2017: Synapse
https://www.readbyqxmd.com/read/28169924/retrograde-maculopathy-in-patients-with-glaucoma
#9
Jacqueline Brazerol, Milko E Iliev, René Höhn, Stephan Fränkl, Hilary Grabe, Mathias Abegg
PURPOSE: Macular optical coherence tomography (OCT) analysis can be used for quantitative measures of optic nerve atrophy at a location far from the optic nerve head. This recently led to the finding of microcystic macular edema (MME), that is vacuolar inclusions in the macular inner nuclear layer, in some glaucoma patients. The involvement of individual retinal layers is yet unclear in glaucoma. In this study we systematically investigated glaucoma-induced changes in macular layers to evaluate whether glaucoma-associated damage extends beyond the macular ganglion cell layer...
May 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28162880/surgical-management-of-periprosthetic-shoulder-infections
#10
Geoffrey P Stone, Rachel E Clark, Kathleen C O'Brien, Lisa Vaccaro, Peter Simon, Adam J Lorenzetti, Brent C Stephens, Mark A Frankle
BACKGROUND: The treatment of periprosthetic joint infection is a difficult challenge in shoulder arthroplasty. This study investigated 1-stage modular component exchange vs. 1-stage complete removal and reimplantation (CRR) vs. 2-stage revision arthroplasty for periprosthetic joint infection. METHODS: Between January 1, 2004, and December 31, 2012, 79 patients received a component exchange (n = 15), CRR (n = 45), or a 2-stage (n = 19) revision for infection. A binary logistic regression analysis was performed to determine factors presenting the greatest risk of reinfection...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28158280/proximate-mechanism-of-behavioral-manipulation-of-an-orb-weaver-spider-host-by-a-parasitoid-wasp
#11
Thiago Gechel Kloss, Marcelo Oliveira Gonzaga, Leandro Licursi de Oliveira, Carlos Frankl Sperber
Some ichneumonid wasps induce modifications in the web building behavior of their spider hosts to produce resistant "cocoon" webs. These structures hold and protect the wasp's cocoon during pupa development. The mechanism responsible for host manipulation probably involves the inoculation of psychotropic chemicals by the parasitoid larva during a specific developmental period. Recent studies indicate that some spiders build cocoon webs similar to those normally built immediately before ecdysis, suggesting that this substance might be a molting hormone or a precursor chemical of this hormone...
2017: PloS One
https://www.readbyqxmd.com/read/28150886/morphometry-of-the-human-clavicle-and-intramedullary-canal-a-3d-geometry-based-quantification
#12
Jazmine R Aira, Peter Simon, Sergio Gutiérrez, Brandon G Santoni, Mark A Frankle
Midshaft clavicle fractures are a very common occurrence. The current treatment of choice involves internal fixation with superior or anterior clavicle plating, however their clinical success and particularly patient satisfaction are decreasing. The implementation of intramedullary devices is on the rise, but data describing the intramedullary canal parameters are lacking. The aim of this study is to quantify the geometry of the clavicle and its intramedullary canal, and to evaluate the effect of gender and anatomical side...
February 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28139387/the-influence-of-patient-and-surgeon-specific-factors-on-operative-duration-and-early-postoperative-outcomes-in-shoulder-arthroplasty
#13
Jonathan C Clark, Peter Simon, Rachel E Clark, Kaitlyn N Christmas, Jesse W Allert, Jonathan J Streit, Mark A Mighell, Alfred Hess, Jeffrey Stone, Mark A Frankle
BACKGROUND: Increased operative duration has been shown to have demonstrable effects on the outcomes and complications in multiple areas of orthopedic surgery. We sought to determine if patient- and surgeon-specific factors correlated to operative duration in shoulder arthroplasty. Our hypothesis was that increased surgeon and trainee volume would decrease operative times and that more complex pathology would increase operative duration. METHODS: A retrospective review of primary and revision total and reverse shoulder arthroplasties performed at a single institution from 2012 through 2015 was performed evaluating the correlation between specific patient and surgeon factors and operative duration...
January 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28129381/comparative-cytogenetics-between-two-important-songbird-models-the-zebra-finch-and-the-canary
#14
Michelly da Silva Dos Santos, Rafael Kretschmer, Carolina Frankl-Vilches, Antje Bakker, Manfred Gahr, Patricia C M O Brien, Malcolm A Ferguson-Smith, Edivaldo H C de Oliveira
Songbird species (order Passeriformes, suborder Oscines) are important models in various experimental fields spanning behavioural genomics to neurobiology. Although the genomes of some songbird species were sequenced recently, the chromosomal organization of these species is mostly unknown. Here we focused on the two most studied songbird species in neuroscience, the zebra finch (Taeniopygia guttata) and the canary (Serinus canaria). In order to clarify these issues and also to integrate chromosome data with their assembled genomes, we used classical and molecular cytogenetics in both zebra finch and canary to define their chromosomal homology, localization of heterochromatic blocks and distribution of rDNA clusters...
2017: PloS One
https://www.readbyqxmd.com/read/28128664/temperament-as-a-predictor-of-nitrous-oxide-inhalation-sedation-success
#15
Travis M Nelson, Thomas M Griffith, Katherine J Lane, Sarat Thikkurissy, JoAnna M Scott
Little is known about implications of temperament for children who receive nitrous oxide inhalation sedation (N2O/O2) for dental care. The aim of this study was to investigate whether child temperament is associated with success in N2O/O2. Child-caregiver dyads were enrolled from patients aged 36-95 months receiving dental care with N2O/O2 at a university-based pediatric dental clinic. To assess child temperament, 48 caregivers completed the Children's Behavior Questionnaire Short Form. Patient behavior was abstracted from Frankl scores recorded in the patient's chart...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/28094285/urinary-exosomes-contain-micrornas-capable-of-paracrine-modulation-of-tubular-transporters-in-kidney
#16
Tannia Gracia, Xiaonan Wang, Ya Su, Elizabeth E Norgett, Timothy L Williams, Pablo Moreno, Gos Micklem, Fiona E Karet Frankl
Exosomes derived from all nephron segments are present in human urine, where their functionality is incompletely understood. Most studies have focused on biomarker discovery rather than exosome function. Through sequencing we identified the miRNA repertoire of urinary exosomes from healthy volunteers; 276 mature miRNAs and 345 pre-miRNAs were identified (43%/7% of reads). Among the most abundant were members of the miR-10, miR-30 and let-7 families. Targets for the identified miRNAs were predicted using five different databases; genes encoding membrane transporters and their regulators were enriched, highlighting the possibility that these miRNAs could modulate key renal tubular functions in a paracrine manner...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28061861/oxidative-status-predicts-quality-in-human-mesenchymal-stem-cells
#17
Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel, Jivko Stoyanov
BACKGROUND: Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations to MSC use: (1) these therapies require large numbers of cells, and long-term expansion of MSC in vitro promotes replicative senescence; and (2) patient variability is a challenge for defining MSC quality standards for transplantation. This study aimed to determine whether low or high oxidative status of MSC correlate with changes in cell expansion and differentiation potentials...
January 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28052213/children-s-responses-to-sensory-stimuli-and-their-behavior-in-the-dental-office
#18
Sagit Nissan, Aviva Yochman, Sigalit Blumer, Johnny Kharouba, Benjamin Peretz
OBJECTIVES: To evaluate children's behavior during dental examinations, their reactions to various selected sensory stimuli and the association between them. STUDY DESIGN: Sixty-three children (28 boys and 35 girls) aged 5-12 years (mean age 7.9 ± 1.6 years) participated in the study. Their parents were asked to complete a questionnaire while in the dentist's waiting room. The dentists evaluated the children's behavior in the dental office using Frankl's behavioral scale and noted the children's reactions to the sensory stimuli of touch, noise, smell and backward tilting of the examination chair...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28045035/pdlim5-links-kidney-anion-exchanger-1-kae1-to-ilk-and-is-required-for-membrane-targeting-of-kae1
#19
Ya Su, Thomas F Hiemstra, Yahui Yan, Juan Li, Hannah I Karet, Lawrence Rosen, Pablo Moreno, Fiona E Karet Frankl
Anion exchanger 1 (AE1) mediates Cl(-)/HCO3(-) exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. AE1's C-terminal tail (AE1C) contains multiple potential membrane targeting/retention determinants, including a predicted PDZ binding motif, which are critical for its normal membrane residency. Here we identify PDLIM5 as a direct binding partner for AE1 in human kidney, via PDLIM5's PDZ domain and the PDZ binding motif in AE1C. Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex in which PDLIM5 provides a bridge between ILK and AE1C...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034540/reverse-shoulder-arthroplasty-in-patients-younger-than-55-years-2-to-12-year-follow-up
#20
Randall J Otto, Rachel E Clark, Mark A Frankle
BACKGROUND: This study reports the outcomes of reverse shoulder arthroplasty (RSA) in patients younger than 55 years with midterm to long-term follow-up. METHODS: Sixty-seven patients (average age, 47.9 years; range, 21-54 years) were identified who underwent RSA with an average 62.3 months of follow-up (24-144 months). There were 35 patients (group 1) who had a failed arthroplasty and 32 patients (group 2) who underwent primary RSA. Clinical outcomes included the American Shoulder and Elbow Surgeons (ASES) score, Simple Shoulder Test (SST) score, and range of motion...
December 26, 2016: Journal of Shoulder and Elbow Surgery
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