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https://www.readbyqxmd.com/read/29876970/failure-to-detect-amphetamine-induced-dopamine-release-in-the-cortex-with-11-c-flb-457-positron-emission-tomography-pet-methodological-considerations
#1
Joshua Gertler, Savannah Tollefson, Rehima Jordan, Michael Himes, N Scott Mason, W Gordon Frankle, Rajesh Narendran
Studies in nonhuman primates and humans have demonstrated that amphetamine-induced dopamine release in the cortex can be measured with [11 C]FLB 457 and PET imaging. This technique has been successfully used in recent clinical studies to show decreased dopamine transmission in the prefrontal cortex in schizophrenia and alcohol dependence. Here, we present data from a cohort of twelve healthy controls in whom an oral amphetamine challenge (0.5 mg kg-1 ) did not lead to a significant reduction in [11 C]FLB 457 BPND (i...
June 6, 2018: Synapse
https://www.readbyqxmd.com/read/29793563/effectiveness-of-acupressure-on-dental-anxiety-in-children
#2
Priyanka Avisa, Rekhalakshmi Kamatham, Kalasandhya Vanjari, Sivakumar Nuvvula
PURPOSE: Acupressure is a non-invasive variant of acupuncture and is known to reduce general anxiety. The purpose of this study was to test acupressure's effect on children's dental anxiety. METHODS: Eight- to 12-year-old children undergoing scaling and/or restorative procedures were randomly assigned to one of the following groups: acupressure (Group 1); sham (Group 2); or control (Group 3). Anxiety was recorded for all the children using the Modified Child Dental Anxiety scale (MCDAS)...
May 15, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29750619/a-study-of-the-relationship-of-parenting-styles-child-temperament-and-operatory-behavior-in-healthy-children
#3
Amanda K Tsoi, Stephen Wilson, S Thikkurissy
AIM: The purpose of this study was to assess the relationship of the child's temperament, parenting styles, and parents' prediction of their child's behavior in the dental setting. STUDY DESIGN: Subjects were healthy children 4-12 years of age attending a dental clinic. A Parenting Styles and Dimensions Questionnaire (PSDQ) was given to parents to determine their parenting style. Parents completed the Emotionality, Activity, Sociability Temperament (EAS) survey to measure their child's temperament...
May 11, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29743334/randomised-controlled-trial-of-high-versus-ad-libitum-water-intake-in-patients-with-autosomal-dominant-polycystic-kidney-disease-rationale-and-design-of-the-drink-feasibility-trial
#4
Ragada El-Damanawi, Michael Lee, Tess Harris, Laura B Mader, Simon Bond, Holly Pavey, Richard N Sandford, Ian B Wilkinson, Alison Burrows, Przemyslaw Woznowski, Yoav Ben-Shlomo, Fiona E Karet Frankl, Thomas F Hiemstra
INTRODUCTION: Vasopressin stimulates cyst growth in autosomal dominant polycystic kidney disease (ADPKD) leading to enlarged kidneys, hypertension and renal failure. Vasopressin receptor blockade slows disease progression. Physiological suppression of vasopressin secretion through high water (HW) intake could achieve a similar effect, necessitating a definitive large-scale trial of HW intake in ADPKD. The objective of the DRINK trial is to answer the key design and feasibility questions required to deliver a successful definitive water intake trial...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29710349/toward-a-renewal-of-patient-care-insights-from-viktor-frankl-md-phd
#5
Joseph R Laracy, Michael D Kelly
No abstract text is available yet for this article.
May 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29680874/utility-and-proposed-algorithm-of-csf-flow-cytometry-in-hematologic-malignancies
#6
Bernard Tawfik, Larry Brown, Frankling Fuda, Weina Chen, Shuang Niu, Joseph Sailors, Navid Sadeghi
In patients with hematologic malignancies, multiparameter flow cytometry (FCM) offers greater sensitivity than cytology in detecting malignant cells in the initial cerebrospinal fluid (CSF) specimen. However, the role of FCM in assessment of subsequent specimens is unclear. We developed an algorithm to reduce the number of low-yield FCM tests without significant impact on clinically meaningful results. Patients with hematologic malignancies were studied in a derivation cohort, and the following algorithm was developed: (1) cytology and FCM on all initial samples, (2) cytology on all subsequent samples, and (3) FCM on subsequent samples only if previous FCM was positive...
April 21, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29610973/subspinal-impingement-clinical-outcomes-of-arthroscopic-decompression-with-one-year-minimum-follow-up
#7
Frankl Michal, Eyal Amar, Ran Atzmon, Zachary Sharfman, Barak Haviv, Gilad Eisenberg, Ehud Rath
PURPOSE: This study was designed to (1) evaluate the clinical outcomes after arthroscopic subspinal decompression in patients with hip impingement symptoms and low AIIS, and to (2) assess the presence of low anterior inferior iliac spine on the pre-operative radiographs of patients with established subspinal impingement diagnosed intra-operatively. METHODS: Retrospective analysis of patients who underwent arthroscopic subspinal decompression has been performed. The indications for surgery were femoroacetabular impingement (FAI), or subspinal impingement...
April 2, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29605518/shoulder-arthroplasty-for-sequelae-of-obstetrical-brachial-plexus-injury
#8
Jean-David Werthel, Bradley Schoch, Mark Frankle, Robert Cofield, Bassem T Elhassan
PURPOSE: Shoulder arthroplasty following obstetrical brachial plexus injury (OBPI) is technically challenging because glenoid morphology, muscle balance, and humeral version are substantially altered compared with the neurologically intact shoulder. The purpose of this study is to report the outcome of shoulder arthroplasty in a group of patients with end-stage arthritis secondary to OBPI. MATERIALS AND METHODS: Seven patients with OBPI and secondary glenohumeral arthritis were treated with shoulder arthroplasty between 1976 and 2014...
March 29, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29596853/exenatide-has-a-pronounced-effect-on-energy-intake-but-not-energy-expenditure-in-non-diabetic-subjects-with-obesity-a-randomized-double-blind-placebo-controlled-trial
#9
Alessio Basolo, Joshua Burkholder, Kristy Osgood, Alexis Graham, Sarah Bundrick, Joseph Frankl, Paolo Piaggi, Marie S Thearle, Jonathan Krakoff
AIMS: Exenatide is a glucagon-like peptide 1 (GLP-1) mimetic which induces weight loss predominantly, it is presumed, via decreased food intake. However, circulating GLP-1 is also a determinant of energy expenditure. We sought to quantify the effect of exenatide on energy expenditure (EE) and energy intake. MATERIALS AND METHODS: In this single-center, randomized double-blind placebo controlled trial, we randomized 80 healthy, non-diabetic volunteers with obesity (46 women, age: 34...
March 26, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29576104/the-dark-ages-of-maternal-sepsis-time-to-be-enlightened
#10
EDITORIAL
C C Frankling, S Finfer, D Lissauer, A Perner, J M Patel, F Gao
No abstract text is available yet for this article.
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29573375/anaesthetic-efficacy-of-4-articaine-and-2-lidocaine-for-extraction-and-pulpotomy-of-mandibular-primary-molars-an-equivalence-parallel-prospective-randomized-controlled-trial
#11
Fatma Alzahrani, Monty S Duggal, Theresa Munyombwe, Jinous F Tahmassebi
AIM: To compare the anaesthetic efficacy for pain and behaviour during treatment with mandibular infiltration using 4% articaine (BI) with inferior dental nerve clock (IDNB) using 2% lidocaine for extraction or pulp therapy in mandibular primary molars. DESIGN: This was equivalence parallel prospective RCT. A total of 98 children aged 5-9 years old were randomly assigned into two groups: BI supplemented by buccal intrapapillary infiltration with 4% articaine; IDNB with 2% lidocaine supplemented with long buccal infiltration...
May 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29569459/a-video-eyeglasses-earphones-system-as-distracting-method-during-dental-treatment-in-children-a-crossover-randomised-and-controlled-clinical-trial
#12
A Garrocho-Rangel, E Ibarra-Gutiérrez, M Rosales-Bérber, R Esquivel-Hernández, V Esparza-Villalpando, A Pozos-Guillén
AIM To evaluate the effectiveness of a Video Eyeglasses/Earphones System (VEES) as distracting device in reducing anxiety in children during dental procedures carried out under local anaesthesia. MATERIALS AND METHODS: In this crossover clinical trial, 36 Frankl scale II and III children aged 5-8 years received different dental procedures in two sessions, with and without the VEES system. In the control visit, they were not exposed to this distraction stimulus, but traditional non-aversive behaviour management was applied...
March 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29569452/single-tooth-anaesthesia-a-new-approach-to-the-paediatric-patient-a-clinical-experimental-study
#13
L Giannetti, E Forabosco, E Spinas, D Re, A Murri Dello Diago
AIM: The objective of this study is to assess the efficacy of the STA Wand System with respect to pain and fear reduction in paediatric patients and by using the Single Tooth Anaesthesia (STA) technique. MATERIALS AND METHODS: Patients included children and teenagers between 6 and 17 years of age, who required the administration of local anaesthesia prior to expected treatments. Local anaesthesia was performed by means of the electronic STA Wand System (Milestone scientific...
March 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29541167/effect-of-painless-sta-on-tooth-extraction-of-elderly-patients-with-periodontal-diseases
#14
Li Feng, Haiming Wang, Ming Lin
This study compared the effects of tooth extractions under novel painless single tooth anesthesia (STA) and conventional anesthesia on elderly patients with periodontal diseases, and the impact of painless STA on clinical indicators of the patients. Elderly patients (n=116) with periodontal diseases who were treated in Jinan Central Hospital were selected to undergo extraction operation on loose teeth; all the patients were randomly divided into two groups. The tooth extraction operations were performed after painless STA and cartridge anesthesia; the effects of the tooth extraction operations and the operation time were recorded; Visual Analogue Scale (VAS), Kuttner facial expression scale, Frankl treatment compliance scale and Houpt behavior rating scale were utilized to assess and record the clinical indicators of the patients during the operations; the impacts of the two anesthesia techniques on the effect of the tooth extraction of patients with periodontal diseases were comprehensively analyzed...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29514657/effects-of-child-characteristics-and-dental-history-on-dental-fear-cross-sectional-study
#15
Mohammad A Alshoraim, Azza A El-Housseiny, Najat M Farsi, Osama M Felemban, Najlaa M Alamoudi, Amani A Alandejani
BACKGROUND: Dental fear (DF) is a challenging problem in dentistry. It is multifactorial in origin and many contributing factors have been identified. The aim of the study was to assess dental fear among 12-15 years old Arabic speaking children in Jeddah, Saudi Arabia and its relation to demographic variables, previous dental experience, and child behaviour. METHODS: In this cross-sectional study, a total of 1522 boys and girls from middle schools in Jeddah, Saudi Arabia participated in this study during the period of 2014 to 2016...
March 7, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29494712/humeral-bone-loss-in-revision-shoulder-arthroplasty
#16
Paul B McLendon, Jacob L Cox, Mark A Frankle
Revision shoulder arthroplasty is becoming more prevalent as the rate of primary shoulder arthroplasty in the US continues to increase. The management of proximal humeral bone loss in the revision setting presents a difficult problem without a clear solution. Different preoperative diagnoses often lead to distinctly different patterns of bone loss. Successful management of these cases requires a clear understanding of the normal anatomy of the proximal humerus, as well as structural limitations imposed by significant bone loss and the effect this loss has on component fixation...
February 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29455478/-comparision-of-clinical-effects-between-one-stage-anterior-and-posterior-approach-in-treating-thoracolumbar-tuberculosis-with-debridement-and-internal-fixation
#17
Bin Lin, Li-Lin Dai, Zhi-da Chen, Yong Zheng
OBJECTIVE: To compare the outcomes of surgical operation by posterior or anterior approach only for thoracolumbar tuberculosis. METHODS: The clinical data of 97 patients with thoracolumbar tuberculosis underwent debridement and internal fixation from January 2005 to December 2014 were retrospectively analyzed. The study included 59 males and 38 females, with a mean age of 53.7 years ranged from 20 to 68 years. The course of disease was from 1 to 13 months with an average of (6...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29433645/difficulty-in-decision-making-in-the-treatment-of-displaced-proximal-humerus-fractures-the-effect-of-uncertainty-on-surgical-outcomes
#18
Joey LaMartina, Kaitlyn N Christmas, Peter Simon, Jonathan J Streit, Jesse W Allert, Jonathan Clark, Randall J Otto, Adham Abdelfattah, Mark A Mighell, Mark A Frankle
BACKGROUND: Decision making in the management of proximal humerus fractures can be difficult in situations in which the surgeon is uncertain of the ideal treatment. METHODS: Two shoulder surgeons operatively treated 476 proximal humerus fractures from 1998-2014 with open reduction-internal fixation (ORIF), hemiarthroplasty, or reverse shoulder arthroplasty. Operative treatment was stratified by year to determine the evolution of technological influences on treatment over time...
March 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29380617/reliability-and-validity-of-the-italian-versions-of-the-children-s-fear-survey-schedule-dental-subscale-and-the-modified-child-dental-anxiety-scale
#19
L Paglia, S Gallus, S de Giorgio, S Cianetti, E Lupatelli, G Lombardo, A Montedori, P Eusebi, R Gatto, S Caruso
AIM: Children's dental fear and anxiety (DFA) causes significant problems in clinical practice. The 15-item Children's Fear Survey Schedule - Dental Subscale (CFSS-DS) and the 8-item Modified Child Dental Anxiety Scale (MCDAS) are the most widely used measures of dental fear in children. The aim of this study is to examine the reliability and validity of the Italian versions of the CFSS-DS and MCDAS, also in comparison with a simple visual analogue scale (VAS). MATERIALS AND METHODS: The CFSS-DS and MCDAS were translated into Italian by a consensus panel of experts and administered to 210 dental patients aged 4-11 years from three Italian Institutions...
December 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29372389/lothar-von-frankl-hochwart-1862-1914
#20
Lazaros C Triarhou
No abstract text is available yet for this article.
January 25, 2018: Journal of Neurology
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