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https://www.readbyqxmd.com/read/28100205/a-fast-and-effective-determination-of-the-biodistribution-and-subcellular-localization-of-fluorescent-immunoliposomes-in-freshly-excised-animal-organs
#1
Felista L Tansi, Ronny Rüger, Ansgar M Kollmeier, Claudia Böhm, Roland E Kontermann, Ulf K Teichgraeber, Alfred Fahr, Ingrid Hilger
BACKGROUND: Preclinical research implementing fluorescence-based approaches is inevitable for drug discovery and technology. For example, a variety of contrast agents developed for biomedical imaging are usually evaluated in cell systems and animal models based on their conjugation to fluorescent dyes. Biodistribution studies of excised organs are often performed by macroscopic imaging, whereas the subcellular localization though vital, is often neglected or further validated by histological procedures...
January 18, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28098946/negative-association-between-mr-spectroscopic-glutamate-markers-and-gray-matter-volume-after-alcohol-withdrawal-in-the-hippocampus-a-translational-study-in-humans-and-rats
#2
Ulrich Frischknecht, Derik Hermann, Nuran Tunc-Skarka, Guo-Ying Wang, Markus Sack, Julia van Eijk, Traute Demirakca, Claudia Falfan-Melgoza, Bertram Krumm, Sandra Dieter, Rainer Spanagel, Falk Kiefer, Karl F Mann, Wolfgang H Sommer, Gabriele Ende, Wolfgang Weber-Fahr
BACKGROUND: Both chronic alcohol consumption and alcohol withdrawal lead to neural tissue damage which partly recovers during abstinence. This study investigated withdrawal-associated changes in glutamatergic compounds, markers of neuronal integrity, and gray matter volumes during acute alcohol withdrawal in the hippocampus, a key region in development and maintenance of alcohol dependence in humans and rats. METHODS: Alcohol-dependent patients (N = 39) underwent magnetic resonance imaging (MRI) and MR spectroscopy (MRS) measurements within 24 hours after the last drink and after 2 weeks of abstinence...
January 18, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28091340/fahr-s-disease-presenting-as-late-onset-levodopa-responsive-parkinsonism
#3
Niraj Kumar, Mandar Jog
No abstract text is available yet for this article.
January 16, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28062744/fahr-and-further
#4
Martin Windpessl, Petra Müller, Manfred Wallner
No abstract text is available yet for this article.
January 5, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27922640/brain-network-reorganization-differs-in-response-to-stress-in-rats-genetically-predisposed-to-depression-and-stress-resilient-rats
#5
N Gass, R Becker, A J Schwarz, W Weber-Fahr, C Clemm von Hohenberg, B Vollmayr, A Sartorius
Treatment-resistant depression (TRD) remains a pressing clinical problem. Optimizing treatment requires better definition of the specificity of the involved brain circuits. The rat strain bred for negative cognitive state (NC) represents a genetic animal model of TRD with high face, construct and predictive validity. Vice versa, the positive cognitive state (PC) strain represents a stress-resilient phenotype. Although NC rats show depressive-like behavior, some symptoms such as anhedonia require an external trigger, i...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27867902/hypocalcemia-and-fahr-syndrome-in-a-patient-with-graves-disease-difficult-etiological-diagnosis
#6
Ibtissem Oueslati, Karima Khiari, Najla Bchir, Néjib Ben Abdallah
No abstract text is available yet for this article.
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27811930/defining-the-brain-circuits-involved-in-psychiatric-disorders-imi-newmeds
#7
Francesc Artigas, Esther Schenker, Pau Celada, Michael Spedding, Laia Lladó-Pelfort, Noemi Jurado, Mercedes Núñez, Noemi Santana, Eva Troyano-Rodriguez, Maurizio S Riga, Hanna van den Munkhof, Anna Castañé, Hamdy Shaban, Thérèse M Jay, Anushree Tripathi, Bill P Godsil, Claude Sebban, Jean Mariani, Philippe Faure, Samir Takkilah, Zoe A Hughes, Chester J Siok, Mihaily Hajos, Karsten Wicke, Natalia Gass, Wolfgang Weber-Fahr, Alexander Sartorius, Robert Becker, Michael Didriksen, Jesper F Bastlund, Mark Tricklebank, Céline Risterucci, Andreas Meyer-Lindenberg, Adam J Schwarz
Despite the vast amount of research on schizophrenia and depression in the past two decades, there have been few innovative drugs to treat these disorders. Precompetitive research collaborations between companies and academic groups can help tackle this innovation deficit, as illustrated by the achievements of the IMI-NEWMEDS consortium.
January 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27764521/fahr-s-syndrome-and-clinical-correlation-a-case-series-and-literature-review
#8
M Pistacchi, M Gioulis, F Sanson, S M Marsala
INTRODUCTION: Fahr's disease is characterized by bilateral calcium deposition within the basal ganglia, cerebellar dentate nucleus and subcortical brain white matter. The main clinical manifestations are rigid or hyperkinetic syndrome, mood disorders and cognitive impairment. The correlation between neurological impairment and symmetrical basal ganglia calcification is not so frequent. Aim of the study was to report the results of neurological assessment of three sporadic cases of Fahr's disease highlighting a correlation between the clinical syndrome and neuroimaging...
2016: Folia Neuropathologica
https://www.readbyqxmd.com/read/27762118/fahr-s-disease-with-seizure-presentation
#9
Rangaswamy, V Ranjith, L Vikas, R Santosh
Fahr's disease or Fahr's syndrome is a rare neurodegenerative disorder characterized by abnormal symmetrical calcifications of the basal ganglia, thalami, sub-cortical hemispheric white matter and deep cerebellar nuclei. It can be idiopathic or associated with an endocrinopathy, frequently with parathyroid disorder. Clinical spectrum of the disease is wide ranging from neurological features like seizure, syncope, stroke like events, extra-pyramidal symptoms often combined with frontal sub-cortical pattern of behavioural dysfunction and psychiatric symptoms such as psychosis, mood disorder and dementia...
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27750473/investigations-of-the-influence-of-liposome-composition-on-vesicle-stability-and-drug-transfer-in-human-plasma-a-transfer-study
#10
Stephan Holzschuh, Kathrin Kaeß, Guilherme Volpe Bossa, Christiane Decker, Alfred Fahr, Sylvio May
Liposomal delivery constitutes a promising approach for i.v. administration of mTHPC because lipid membranes can host these drug molecules. This study investigates the transfer and release of temoporfin (mTHPC) to plasma proteins and stability of various liposomal formulations. To this end, we employed traces of radioactive markers and studied the effects of fatty acid chain length and the degree of saturation in the lipophilic tail, addition of cholesterol, and PEGylation of the membrane surface and different drug-to-lipid ratios...
October 18, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27734300/early-effects-of-a-high-caloric-diet-and-physical-exercise-on-brain-volumetry-and-behavior-a-combined-mri-and-histology-study-in-mice
#11
Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27727841/fahr-s-disease-presenting-as-supranuclear-palsy
#12
Rakesh Mp, Kshitija Jain, Priyank S Dumade, Dumade Gala, Salman Ali Sayyed
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27672489/fahr-s-disease-or-fahr-s-syndrome
#13
Malathi Latha Perugula, Steven Lippmann
No abstract text is available yet for this article.
July 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/27664019/restricted-vs-unrestricted-wheel-running-in-mice-effects-on-brain-behavior-and-endocannabinoids
#14
Sarah V Biedermann, Matthias K Auer, Laura Bindila, Gabriele Ende, Beat Lutz, Wolfgang Weber-Fahr, Peter Gass, Johannes Fuss
Beneficial effects of voluntary wheel running on hippocampal neurogenesis, morphology and hippocampal-dependent behavior have widely been studied in rodents, but also serious side effects and similarities to stereotypy have been reported. Some mouse strains run excessively when equipped with running wheels, complicating the comparability to human exercise regimes. Here, we investigated how exercise restriction to 6h/day affects hippocampal morphology and metabolism, stereotypic and basal behaviors, as well as the endocannabinoid system in wheel running C57BL/6 mice; the strain most commonly used for behavioral analyses and psychiatric disease models...
November 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27642620/dataset-on-fap-induced-emergence-of-spontaneous-metastases-and-on-the-preparation-of-activatable-fap-targeting-immunoliposomes-to-detect-the-metastases
#15
Felista L Tansi, Ronny Rüger, Claudia Böhm, Roland E Kontermann, Ulf K Teichgraeber, Alfred Fahr, Ingrid Hilger
The underlying data demonstrates that fibroblast activation protein (FAP) paves the way for fibrosarcoma cells, which require the proteolysis of the extracellular matrix (ECM) and basement membranes to intravasate from implanted subcutaneous primary tumors into blood vessels, be transported to distant organs where they extravasate from the blood vessels, reattach and proliferate to metastases. The data additionally shows that FAP, when overexpressed on fibrosarcoma cells induces their invasion and formation of spontaneous metastases in multiple organs, particularly after subcutaneous co-implantation of the FAP-expressing and wildtype fibrosarcoma...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27620074/transdermal-delivery-from-liposomal-formulations-evolution-of-the-technology-over-the-last-three-decades
#16
Mukul Ashtikar, Kalpa Nagarsekar, Alfred Fahr
Strong barrier properties of stratum corneum often limits the efficiency of drug delivery through skin. Several strategies were tried to improve permeation of drug through skin for local as well as systemic drug delivery. Incorporation of the drug within flexible liposomal vesicles has been one of the popular and well-studied approaches for delivering drug to deeper layers of the skin or even systemic circulation. Flexible/deformable/elastic liposomal systems such as invasomes, Transfersomes(®), ethosomes, niosomes, etc...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27608765/bilateral-strio-pallido-dentate-calcinosis-fahr-s-disease-report-of-seven-cases-and-revision-of-literature
#17
Elisabetta Savino, Cecilia Soavi, Eleonora Capatti, Massimo Borrelli, Giovanni B Vigna, Angelina Passaro, Giovanni Zuliani
BACKGROUND: Fahr's disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and movement disorders. The term "Fahr's syndrome" is used in presence of calcifications secondary to a specific cause, but the variability of etiology, pathogenesis, and clinical picture underlying this condition have raised the question of the real existence of a syndrome...
September 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27524543/unexplained-neuropsychiatric-symptoms-in-intensive-care-a-fahr-syndrome-case
#18
Duygu Kayar Calili, Nevzat Mehmet Mutlu, Ayse Pinar Mutlu Titiz, Zeynep Nur Akcaboy, Eda Macit Aydin, Isil Ozkocak Turan
Fahr Syndrome is a rare disease where calcium and other minerals are stored bilaterally and symmetrically in the basal ganglia, cerebellar dentate nucleus and white matter. Fahr Syndrome is associated with various metabolic disorders, mainly parathyroid disorders. The presented case discusses a 64-year old male patient admitted to the intensive care unit of our hospital diagnosed with aspiration pneumonia and urosepsis. The cranial tomography examination to explain his nonspecific neurological symptoms showed bilateral calcifications in the temporal, parietal, frontal, occipital lobes, basal ganglia, cerebellar hemisphere and medulla oblongata posteriorly...
August 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27520626/fahr-s-disease
#19
A Schattner, I Dubin, Y Drahy, M Gelber
No abstract text is available yet for this article.
October 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27400114/fahr-s-syndrome-associated-with-multiple-intracranial-aneurysms-a-case-report
#20
Umit Eroglu, Gökmen Kahilogullari, Altan Demirel, Anıl Arat, Agahan Unlu
Fahr's Syndrome is characterized by the presence of intracerebral, bilateral and symmetrical calcifications located in bilateral basal ganglia, thalamus, and cerebellum. The etiology is not exactly known. The authors reported a very rare case who had Fahr's Syndrome and intracerebral aneurysms simultaneously. The patient was female and presented with headache. Her examinations revealed aneurysms on the middle cerebral artery, internal carotid artery and ophthalmic artery. That is the first case reported in the literature having multiple intracranial aneurysms and Fahr's Syndrome together...
2016: Turkish Neurosurgery
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