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JOURNAL ARTICLE
Mariana Reis Guedes, Sylvana Izaura Salyba Rendeiro de Noronha, Máira Tereza Talma Chírico, Gabriela Dias Carvalho da Costa, Thalles de Freitas Castro, Rory Cristiane Fortes de Brito, Lucas Gabriel Vieira, Thayane Oliveira Reis, Marcelo Carlos Ribeiro, Alexandre Barbosa Reis, Cláudia Martins Carneiro, Frank Silva Bezerra, Nicola Montano, Valdo José Dias da Silva, Rodrigo Cunha de Menezes, Deoclécio Alves Chianca-Jr, Fernanda Cacilda Silva
UNLABELLED: Malnutrition results in autonomic imbalance and heart hypertrophy. Overexpression of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the left ventricles (LV) is linked to hypertrophied hearts and abnormal myocardium automaticity. Given that ivabradine (IVA) has emerging pleiotropic effects, in addition to the widely known bradycardic response, this study evaluated if IVA treatment could repair the autonomic control and cardiac damages in malnourished rats...
April 11, 2024: Life Sciences
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JOURNAL ARTICLE
Ildamara Canoa de Oliveira, Mariana Zanco, Juliana Lopes, Milena Paloma Sambo, Thiago Antonio Moretti de Andrade, Gláucia Maria Tech Dos Santos, Maira Felonato, Milton Santamaria-Jr
BACKGROUND AND OBJECTIVE: The biological effects of atmospheric plasma (cold plasma) show its applicability for controlling the etiological factors that involve tissue repair. Thus, the study evaluated the effect of atmospheric plasma therapy in the control of tissue inflammation and bone remodeling in experimental periodontitis. METHODS: Fifty-six rats were subjected to ligation in the cervical region of the first maxillary molars (8 weeks). The animals were divided into two groups (n = 28): periodontitis without treatment group (P group), and periodontitis with atmospheric plasma treatment group (P + AP group)...
April 2, 2024: Journal of Periodontal Research
#3
JOURNAL ARTICLE
R I Pongeluppi, R A Monteiro Cardoso, E L Zucoloto Jr, M F M Ballestero, R Santos De Oliveira, D G Abud, J A Farina Jr, B O Colli
BACKGROUND: Scalp arteriovenous malformations (SAVM) are extremely uncommon vascular malformations, with only ~200 cases published in the English language in the past years. The objective of the present study was to describe the experience of a single reference service in neurosurgery. METHODS: This is a descriptive and retrospective study conducted at our institution, which included cases of SAVM treated between 2001 and 2022. All information were extracted from the medical records of our institution...
2024: Acta Chirurgiae Plasticae
#4
JOURNAL ARTICLE
Sergio Fernando Nunes Coelho, Airton Germano Bispo-Jr, Nagyla Alves de Oliveira, Italo Odone Mazali, Fernando Aparecido Sigoli
Lanthanide (LnIII )-doped sodium gadolinium tetrafluoride (NaGdF4 ) nanoparticles have been excelled as attractive upconversion systems for anti-counterfeiting or energy conversion for instance, with a special interest in the visible upconversion of EuIII and TbIII . The core@shell architecture has enabled the bright upconversion of EuIII and TbIII in this matrix by interfacial energy transfer sensibilized by the TmIII /YbIII pair. Another approach to enable EuIII and TbIII upconversion could be the interparticle energy transfer (IPET) between LnIII -doped sensitizer and acceptor nanoparticles...
March 11, 2024: Nanoscale
#5
REVIEW
Camilla Almeida Menezes, Langia Colli Montresor, Soraya Torres Gaze Jangola, Aline Carvalho de Mattos, Ana Lúcia Coutinho Domingues, Arnaldo Maldonado Júnior, Clélia Christina Mello Silva, Constança Simões Barbosa, Cristiane Lafetá Furtado de Mendonça, Cristiano Lara Massara, Cristina Toscano Fonseca, Edward José de Oliveira, Elainne Christine de Souza Gomes, Elizângela Feitosa da Silva, Fernando Schemelzer de Moraes Bezerra, Floriano Paes Silva-Jr, Isadora Cristina de Siqueira, José Roberto Machado E Silva, Leo Heller, Leonardo Paiva Farias, Lilian C Nobrega Holsbach Beck, Mariana Cristina Silva Santos, Mariana Gomes Lima, Marina de Moraes Mourão, Martin Johannes Enk, Monica Ammon Fernandez, Naftale Katz, Omar Dos Santos Carvalho, Patrícia Martins Parreiras, Renata Heisler Neves, Sandra Grossi Gava, Sheilla Andrade de Oliveira, Silvana Carvalho Thiengo, Tereza Cristina Favre, Carlos Graeff-Teixeira, Otávio Sarmento Pieri, Roberta Lima Caldeira, Rosiane A da Silva-Pereira, Roberto Sena Rocha, Ricardo Riccio Oliveira
The World Health Organization (WHO) recognizes schistosomiasis as one of the Neglected Tropical Diseases targeted for global elimination in the 2030 Agenda of the Sustainable Development Goals. In Brazil, schistosomiasis mansoni is considered a public health problem, particularly prevalent among vulnerable populations living in areas with poor environmental and sanitary conditions. In 2022, the WHO published a Guideline encompassing recommendations to assist national programs in endemic countries in achieving morbidity control, eliminating schistosomiasis as a public health problem, and advancing towards interrupting transmission...
2023: Frontiers in Immunology
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JOURNAL ARTICLE
Carolina A D Santos, Artemis P Paula, Gentil G Fonseca Filho, Manoella M Alves, Andréia F Nery, Monise G A Pontes, Erianna Y L Macedo, Ruy M Oliveira, Sabrinna M Freitas, Sarah Lima, Fernanda V C Varela, Andrezza L S Viana, Aline L P Silva, Érika G C Silva, Lília D'Souza-Li
OBJECTIVES: To determine the effects of in-utero exposure to maternal SARS-CoV-2 infection on offspring's neurodevelopment during the first year of life. METHODS: We performed a prospective cohort of babies exposed to SARS-CoV-2 during pregnancy, and a control group (CG) of unexposed babies in a low-income area in Brazil. Children's neurodevelopment was assessed using the guide for Monitoring Child Development in the Integrated Management of Childhood Illness context for both groups (at 1,2,3,4,5,6, 9, and 12 months), and the Ages & Stages Questionnaire (ASQ-3) for the exposed group (EG) (at 4, 6 and 12 months)...
February 2024: International Journal of Infectious Diseases: IJID
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JOURNAL ARTICLE
Thilini N Jayasinghe, Axel Spahr
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Castro Dos Santos NC, Furukawa MV, Oliveira-Cardoso I, Cortelli JR, Feres M, Van Dyke T, Rovai ES. Does the use of omega-3 fatty acids as an adjunct to nonsurgical periodontal therapy provide additional benefits in the treatment of periodontitis? A systematic review and meta-analysis. J Periodontal Res. 2022 Jun;57(3):435-447. doi: 10.1111/jre.12984. Epub 2022 Mar 3. PMID: 35243637. SOURCE OF FUNDING: This study was funded by São Paulo Research Foundation (FAPESP) under awards 2020/05875-9 (to NCCS), 2020/05874-2 (to MF), and 2019/14846-5 (to ESR)...
December 2023: Journal of Evidence-based Dental Practice
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JOURNAL ARTICLE
Dilza Trevisan-Silva, Miguel Cosenza-Contreras, Ursula C Oliveira, Nancy da Rós, Débora Andrade-Silva, Milene C Menezes, Ana Karina Oliveira, Jaqueline G Rosa, Ana T A Sachetto, Martin L Biniossek, Niko Pinter, Marcelo L Santoro, Milton Y Nishiyama-Jr, Oliver Schilling, Solange M T Serrano
Snakebite envenomation is classified as a Neglected Tropical Disease. Bothrops jararaca venom induces kidney injury and coagulopathy. HF3, a hemorrhagic metalloproteinase of B. jararaca venom, participates in the envenomation pathogenesis. We evaluated the effects of HF3 in mouse kidney and blood plasma after injection in the thigh muscle, mimicking a snakebite. Transcriptomic analysis showed differential expression of 31 and 137 genes related to kidney pathology after, respectively, 2 h and 6 h...
October 6, 2023: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Fernando M Paschoal-Jr, Ricardo C Nogueira, Karla de Almeida Lins Ronconi, Marcelo de Lima Oliveira, Kelson James Almeida, Ivana Schmidtbauer Rocha, Eric Homero Albuquerque Paschoal, Joelma Karin Sagica Fernandes Paschoal, Luiz Augusto Carneiro D'Albuquerque, Manoel Jacobsen Teixeira, Ronney B Panerai, Edson Bor-Seng-Shu
INTRODUCTION AND OBJECTIVES: Acute liver failure, also known as fulminant hepatic failure (FHF), includes a spectrum of clinical entities characterized by acute liver injury, severe hepatocellular dysfunction and hepatic encephalopathy. The objective of this study was to assess cerebral autoregulation (CA) in 25 patients (19 female) with FHF and to follow up seventeen of these patients before and after liver transplantation. PATIENTS AND METHODS: The mean age was 33...
October 4, 2023: Annals of Hepatology
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JOURNAL ARTICLE
Raul L Ferreira, Walter Muniz Jr, Louise E A Souza, Hector M C Navarro, Lucas R de Mello, Valmor R Mastelaro, Tasso O Sales, Cintya D A E S Barbosa, Adriana S Ribeiro, Emerson R da Silva, Melissa F Landell, Italo N de Oliveira
The emergence of drug-resistant pathogenic microorganisms has become a public health concern, with demand for strategies to suppress their proliferation in healthcare facilities. The present study investigates the physicochemical and antimicrobial properties of carbon dots (CD-MR) derived from the methyl red azo dye. The morphological and structural analyses reveal that such carbon dots present a significant fraction of graphitic nitrogen in their structures, providing a wide emission range. Based on their low cytotoxicity against mammalian cells and tunable photoluminescence, these carbon dots are applied to bioimaging in vitro living cells...
October 4, 2023: ACS Applied Bio Materials
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JOURNAL ARTICLE
J T Lucas Jr, L J Wilson, C Oliveira, S E Braunstein, A M Faught
PURPOSE/OBJECTIVE(S): Publishing and editorial policies differ substantially across the Radiation Oncology (RO) and Medical Physics (MedPhys) compendium of journals. Adoptance of modern standards in scientific publishing and data sharing have the potential to improve the impact and reliability of the RO literature. MATERIALS/METHODS: We characterized the editorial, authorship and peer reviewer policies of various prominent clinical RO (N = 16) and medical physics (N = 9) peer-reviewed journals affiliated with professional societies for characteristics that are associated with improved reproducibility and rigorous review...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
Emeli Chatterjee, Rodosthenis S Rodosthenous, Ville J Kujala, Priyanka Gokulnath, Michail Spanos, H Immo Lehmann, Getulio P de Oliveira-Jr, Mingjian Shi, Tyne W Miller-Fleming, Guoping Li, Ionita Ghiran, Katia Karalis, JoAnn Lindenfeld, Jonathan D Mosley, Emily S Lau, Jennifer E Ho, Quanhu Sheng, Ravi Shah, Saumya Das
BACKGROUND: Cardiorenal syndrome (CRS)-renal injury during heart failure (HF)-is linked to higher morbidity. Whether circulating extracellular vesicles (EVs) and their RNA cargo directly impact its pathogenesis remains unclear. METHODS: We investigated the role of circulating EVs from patients with CRS on renal epithelial/endothelial cells using a microfluidic kidney-on-chip model (KOC). The small RNA cargo of circulating EVs was regressed against serum creatinine to prioritize subsets of functionally relevant EV miRNAs and their mRNA targets investigated using in silico pathway analysis, human genetics, and interrogation of expression in the KOC model and in renal tissue...
September 14, 2023: JCI Insight
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JOURNAL ARTICLE
Bruno Calsa, Ludmilla Scodeler de Camargo, Tainá Jaqueline Bortolança, Camila Andrea de Oliveira, Rosana Catisti, Fernanda Gaspar do Amaral, Milton Santamaria-Jr
OBJECTIVE: Herein, we evaluated pinealectomy-induced melatonin absence to determine its effects on craniofacial and dental development in the offspring. DESIGN: Female Wistar rats in three groups, i.e., intact pregnant rats, pinealectomized pregnant rats (PINX), and pinealectomized pregnant rats subjected to oral melatonin replacement therapy, were crossed 30 days after surgery. The heads of 7-day-old pups were harvested for cephalometric and histological analyses, and maxillae and incisors were collected for mRNA expression analysis...
July 16, 2023: Clinical Oral Investigations
#14
JOURNAL ARTICLE
Flávia Rossi Caruso, Cássia da Luz Goulart, José Carlos Bonjorno Jr, Claudio Ricardo de Oliveira, Renata Gonçalves Mendes, Ross Arena, Audrey Borghi-Silva
BACKGROUND: Weber classification stratifies cardiac patients based on peak oxygen consumption (V̇O2 ), the gold-standard measure of exercise capacity. OBJECTIVE: To determine if Weber classification is a useful tool to discriminate clinical phenotypes in COPD patients and to evaluate if disease severity and other clinical measures can predict V̇O2peak . METHODS: Three hundred and six COPD patients underwent cardiopulmonary exercise testing (CPX) and were divided according to Weber class: 1) Weber A (n = 34); 2) Weber B (n = 88); 3) Weber C (n = 138); and 4) Weber D (n = 46)...
June 24, 2023: Heart & Lung: the Journal of Critical Care
#15
JOURNAL ARTICLE
José Meira, Gonçalo Matos, André Perdigão, José Cação, Carlos Resende, Waldir Moreira, Mário Antunes, José Quevedo, Ruben Moutinho, João Oliveira, Pedro Rendeiro, Pedro Oliveira, Antonio Oliveira-Jr, José Santos, Rui L Aguiar
The next generation of mobile broadband communication, 5G, is seen as a driver for the industrial Internet of things (IIoT). The expected 5G-increased performance spanning across different indicators, flexibility to tailor the network to the needs of specific use cases, and the inherent security that offers guarantees both in terms of performance and data isolation have triggered the emergence of the concept of public network integrated non-public network (PNI-NPN) 5G networks. These networks might be a flexible alternative for the well-known (albeit mostly proprietary) Ethernet wired connections and protocols commonly used in the industry setting...
May 30, 2023: Sensors
#16
JOURNAL ARTICLE
Áquila Rodrigues Costa Santos, Aline Rezende R Abreu, Sylvana I S R Noronha, Thayane Oliveira Reis, Daisy Motta Santos, Deoclécio Alves Chianca-Jr, Luiz Gonzaga da Silva, Rodrigo Cunha Alvim de Menezes, Cibele Velloso-Rodrigues
Obesity and stress are related to cardiovascular diseases. Rats fed a high-fat diet (HFD) show increased cardiovascular reactivity to emotional stress and altered defensive behavioral responses. Indeed, changes in thermoregulatory responses in an aversive environment are observed in these animals. However, studies aimed at clarifying the physiological mechanisms linking obesity, stress hyperreactivity and behavioral changes are needed. The aim of this study was to evaluate the changes in thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress...
April 3, 2023: Physiology & Behavior
#17
JOURNAL ARTICLE
Fernanda Cardoso Lanza, Gilmar Ribeiro-Jr, Diego Lopes Paim Miranda, Fred Luciano Neves Santos, Cristiane Medeiros Moraes de Carvalho, Gabriel Muricy Cunha, Ianei de Oliveira Carneiro, Renato Barbosa Reis, José Maurício Albuquerque Cunha, Cristiane Wanderley Cardoso, Jorgana Fernanda de Souza Soares, Fernando Luiz Vieira de Araújo, Mitermayer Galvão Reis
BACKGROUND: Chagas disease (CD) is caused by Trypanosoma cruzi and transmitted by triatomines. Historical information from the 20th century demonstrates T. cruzi records in the metropolitan region of Salvador (MRS), the third largest urban agglomeration in the Brazilian Northeast and the eighth largest in Brazil, an area with intense migratory activity from CD-endemic regions. Therefore, this study aimed to evaluate CD indicators (prevalence and mortality) in the MRS. METHODS: A mixed ecological and descriptive study was conducted using secondary data...
2023: Revista da Sociedade Brasileira de Medicina Tropical
#18
JOURNAL ARTICLE
Fernanda Valença-Feitosa, Millena Rakel Dos Santos, Gabriela Andrade Conrado Carvalho, Thaciana Dos Santos Alcantara, Alfredo Dias de Oliveira Filho, Divaldo Pereira de Lyra-Jr
INTRODUCTION: Each patient admitted to the hospital is subject to one medication error per day, since the occurrence of this one with the potential to cause harm is three times more common in pediatric hospitalized patients than in adults. These harms can result from inaccurate or incomplete drug use histories when patients undergo a clinical evaluation, which jeopardizes patient safety and compromises hospitalization costs. Thus, medication reconciliation (MC) emerges as a possible solution to avoid the occurrence of these in pediatric patients and directly contributes to reducing costs in the hospital environment and increasing quality of life)...
November 8, 2022: Research in Social & Administrative Pharmacy: RSAP
#19
JOURNAL ARTICLE
S S Cury, J S Oliveira, Cao Biagi-Júnior, Silva Jr Wa, P P Reis, O Cabral-Marques, E N Hasimoto, P P Freire, R F Carvalho
Lung cancer patients with COVID-19 present an increased risk of developing severe disease and, consequently, have poor outcomes. Determining SARS-CoV-2-host interactome in lung cancer cells and tissues, infected or uninfected with SARS-CoV-2, may reveal molecular mechanisms associated with COVID-19 development and severity in lung cancer patients. Here, we integrated transcriptome data of lung tumors from patients with small- or non-small cell lung cancer (SCLC and NSCLC) and normal lung and lung cancer cells infected with SARS-CoV-2...
November 12, 2022: Gene
#20
JOURNAL ARTICLE
Robson C Alnoch, Gabriela S Alves, Jose C S Salgado, Diandra de Andrades, Emanuelle N de Freitas, Karoline M V Nogueira, Ana C Vici, Douglas P Oliveira, Valdemiro P Carvalho-Jr, Roberto N Silva, Marcos S Buckeridge, Michele Michelin, José A Teixeira, Maria de Lourdes T M Polizeli
Xylooligosaccharides (XOS) are widely used in the food industry as prebiotic components. XOS with high purity are required for practical prebiotic function and other biological benefits, such as antioxidant and inflammatory properties. In this work, we immobilized the recombinant endo-1,4-β-xylanase of Malbranchea pulchella (MpXyn10) in various chemical supports and evaluated its potential to produce xylooligosaccharides (XOS) from hydrothermal liquor of eucalyptus wood chips. Values >90% of immobilization yields were achieved from amino-activated supports for 120 min...
November 1, 2022: International Journal of Molecular Sciences
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