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https://www.readbyqxmd.com/read/28068244/-18-f-fluorodeoxyglucose-positron-emission-tomography-predicts-patterns-of-failure-after-definitive-chemoradiation-therapy-for-locally-advanced-non-small-cell-lung-cancer
#1
Nitin Ohri, William R Bodner, Balazs Halmos, Haiying Cheng, Roman Perez-Soler, Steven M Keller, Shalom Kalnicki, Madhur Garg
BACKGROUND: We previously reported that pretreatment positron emission tomography (PET) identifies lesions at high risk for progression after concurrent chemoradiation therapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). Here we validate those findings and generate tumor control probability (TCP) models. METHODS: We identified patients treated with definitive, concurrent CRT for locally advanced NSCLC who underwent staging (18)F-fluorodeoxyglucose/PET/computed tomography...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068178/cetuximab-plus-chemoradiotherapy-in-immunocompetent-patients-with-anal-carcinoma-a-phase-ii-eastern-cooperative-oncology-group-american-college-of-radiology-imaging-network-cancer-research-group-trial-e3205
#2
Madhur K Garg, Fengmin Zhao, Joseph A Sparano, Joel Palefsky, Richard Whittington, Edith P Mitchell, Mary F Mulcahy, Karin I Armstrong, Nassim H Nabbout, Shalom Kalnicki, Bassel F El-Rayes, Adedayo A Onitilo, Daniel J Moriarty, Thomas J Fitzgerald, Al B Benson
Purpose Squamous cell carcinoma of the anal canal (SCCAC) is characterized by high locoregional failure (LRF) rates after sphincter-preserving definitive chemoradiation (CRT) and is typically associated with anogenital human papilloma virus infection. Because cetuximab enhances the effect of radiation therapy in human papilloma virus-associated oropharyngeal squamous cell carcinoma, we hypothesized that adding cetuximab to CRT would reduce LRF in SCCAC. Methods Sixty-one patients with stage I to III SCCAC received CRT including cisplatin, fluorouracil, and radiation therapy to the primary tumor and regional lymph nodes (45 to 54 Gy) plus eight once-weekly doses of concurrent cetuximab...
January 9, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28048060/su-f-j-223-patterns-of-failure-for-laryngeal-cancer-patients-treated-with-definitive-imrt-comparing-two-different-methods-for-determining-the-origin-of-recurrence-from-follow-up-pet-ct-scans
#3
P Brodin, R Kabarriti, I Vogelius, C Guha, S Kalnicki, M Garg, W Tome
PURPOSE: To determine patterns of failure in laryngeal cancer treated with definitive IMRT by comparing two different methods for identifying the recurrence epicenter on follow-up PET/CT. METHODS: We identified 20 patients treated for laryngeal squamous cell carcinoma with definitive IMRT who had loco-regional recurrence diagnosed on PET/CT. Recurrence PET/CT scans were co-registered with the original treatment planning CT using deformable image registration with the VoxAlign deformation engine in MIM Software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047270/su-f-t-231-improving-the-efficiency-of-a-radiotherapy-peer-review-system-for-quality-assurance
#4
S Hsu, A Basavatia, M Garg, S Kalnicki, W Tome
PURPOSE: To improve the efficiency of a radiotherapy peer-review system using a commercially available software application for plan quality evaluation and documentation. METHODS: A commercial application, FullAccess (Radialogica LLC, Version 1.4.4), was implemented in a Citrix platform for peer-review process and patient documentation. This application can display images, isodose lines, and dose-volume histograms and create plan reports for peer-review process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047084/su-f-t-600-influence-of-acuros-xb-and-aaa-dose-calculation-algorithms-on-plan-quality-metrics-and-normal-lung-doses-in-lung-sbrt
#5
R Yaparpalvi, D Mynampati, H Kuo, M Garg, W Tome, S Kalnicki
PURPOSE: To study the influence of superposition-beam model (AAA) and determinant-photon transport-solver (Acuros XB) dose calculation algorithms on the treatment plan quality metrics and on normal lung dose in Lung SBRT. METHODS: Treatment plans of 10 Lung SBRT patients were randomly selected. Patients were prescribed to a total dose of 50-54Gy in 3-5 fractions (10?5 or 18?3). Doses were optimized accomplished with 6-MV using 2-arcs (VMAT). Doses were calculated using AAA algorithm with heterogeneity correction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047051/su-f-t-589-hybridarc-planning-criteria-for-brain-srs
#6
K Jeong, A Basavatia, D Mynampati, M Garg, S Kalnicki, W Tome
PURPOSE: To compare VMAT SRS plans, dynamic conformal arc (DCA) plans, and Brainlab iPlan's capability of planning and delivering brain SRS plans by employing HybridArc. HybridArc utilizes both DCA and IMRT. Using HybridArc, the amount of DCA versus IMRT needs to be optimized. METHODS: Four SRS patients with the aim of reducing brainstem dose were selected for this study. All patients were contoured in iPlan and transferred to Eclipse for VMAT planning. In iPlan, DCA plans were created for each case...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27997054/stereotactic-body-radiotherapy-for-recurrent-head-and-neck-cancer-a-critical-review
#7
REVIEW
Sujith Baliga, Rafi Kabarriti, Nitin Ohri, Hilda Haynes-Lewis, Ravindra Yaparpalvi, Shalom Kalnicki, Madhur K Garg
The management of patients with recurrent head and neck cancers remains a challenging clinical dilemma. Concerns over toxicity with re-irradiation have limited its use in the clinical setting. Stereotactic Body Radiation Therapy (SBRT) has emerged as a highly conformal and precise type of radiotherapy and has the advantage of sparing normal tissue. Although SBRT is an attractive treatment modality, its use in the clinic is limited, given the technically challenging nature of the procedure. In this review, we attempt to provide a comprehensive overview of the role of re-irradiation in patients with recurrent head and neck cancers, with particular attention to the advent of SBRT and its use with systemic therapies such as cetuximab...
December 20, 2016: Head & Neck
https://www.readbyqxmd.com/read/27936894/fractionated-stereotactic-radiation-therapy-for-brain-metastases-a-systematic-review-with-tumor-control-probability-modeling
#8
Sujith Baliga, Madhur K Garg, Jana Fox, Shalom Kalnicki, Patrick A Lasala, Mary R Welch, Wolfgang A Tomé, Nitin Ohri
OBJECTIVES: Fractionated stereotactic radiotherapy (FSRT) is a relatively new option for the treatment of brain metastases. We performed a quantitative systematic review to determine if local control (LC) following is affected by FSRT dosing regimen. METHODS: We reviewed articles describing LC following FSRT for brain metastases. LC data from each study were extracted from actuarial survival curves and aggregated to form a single dataset. LC curves were generated using the Kaplan-Meier method...
December 12, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27675833/patterns-of-failure-and-origin-of-recurrence-on-positron-emission-tomography-computed-tomography-for-laryngeal-cancer-patients-treated-with-definitive-intensity-modulated-radiation-therapy
#9
R Kabarriti, P Brodin, N Ohri, I Vogelius, T J Ow, A Tassler, S Packer, B A Schiff, R V Smith, M Haigentz, C Guha, S Kalnicki, W A Tome, M K Garg
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674946/reasons-for-radiation-therapy-nonadherence-from-the-patient-s-perspective
#10
J Purswani, S Baliga, H Haynes, R Kabarriti, N Ohri, B Rapkin, M K Garg, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674916/continuous-activity-monitoring-during-concurrent-chemoradiation-therapy
#11
N Ohri, R Kabarriti, W R Bodner, K J Mehta, B Halmos, M Haigentz, B Rapkin, C Guha, S Kalnicki, M K Garg
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674812/local-control-after-stereotactic-body-radiation-therapy-for-early-stage-non-small-cell-lung-cancer-a-tale-of-2-schedules
#12
A Lee, N Ohri, J Purswani, R Yaparpalvi, W R Bodner, M K Garg, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674553/outcomes-for-patients-with-locally-advanced-hypopharyngeal-squamous-cell-carcinoma-treated-with-definitive-radiation-using-intensity-modulated-radiation-therapy-with-adaptive-planning
#13
R Kabarriti, G Patel, N Ohri, H Haynes, T J Ow, A Tassler, S Packer, B A Schiff, R V Smith, M Haigentz, C Guha, S Kalnicki, M K Garg
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674364/can-intensity-modulated-proton-therapy-impt-be-an-alternative-to-image-guided-brachytherapy-igbt-for-locally-advanced-cervical-cancer
#14
H C Kuo, K J Mehta, R Yaparpalvi, M Garg, W R Bodner, M W Ho, W A Tome, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674333/an-analysis-of-the-effect-of-intrafraction-organ-motion-on-gynecological-high-dose-rate-brachytherapy-treatment
#15
J N Phillips, R Yaparpalvi, K J Mehta, H C Kuo, S C Desai, J Tang, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674332/are-inversely-planned-dose-distributions-superior-to-manually-optimized-dose-distributions-in-cervix-t-o-hdr-brachytherapy
#16
R Yaparpalvi, K J Mehta, S C Desai, H C Kuo, W A Tome, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673818/hippocampal-avoidance-using-proton-and-photon-treatment-techniques-in-patients-undergoing-pituitary-radiation-therapy
#17
L Goddard, P Brodin, S C Desai, S Kalnicki, W A Tome, M K Garg
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27020104/radiation-therapy-noncompliance-and-clinical-outcomes-in-an-urban-academic-cancer-center
#18
Nitin Ohri, Bruce D Rapkin, Chandan Guha, Shalom Kalnicki, Madhur Garg
PURPOSE: To examine associations between radiation therapy (RT) noncompliance and clinical outcomes. METHODS AND MATERIALS: We reviewed all patients who completed courses of external beam RT with curative intent in our department from the years 2007 to 2012 for cancers of the head and neck, breast, lung, cervix, uterus, or rectum. Patients who missed 2 or more scheduled RT appointments (excluding planned treatment breaks) were deemed noncompliant. Univariate, multivariable, and propensity-matched analyses were performed to examine associations between RT noncompliance and clinical outcomes...
June 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27014526/right-care-for-the-right-patient-each-and-every-time
#19
Amar Basavatia, Jose Fret, Alex Lukaj, Hsiang Kuo, Ravindra Yaparpalvi, Wolfgang A Tome, Shalom Kalnicki
PURPOSE: To implement a biometric patient identification system in the field of radiation oncology. MATERIALS AND METHODS: A biometric system using palm vein scanning technology has been implemented to ensure the delivery of treatment to the correct patient each and every time. By interfacing a palm vein biometrics system (PVBS) (PatientSecure®, Imprivata, Lexington, Massachusetts) with the radiation oncology patient management system (ROPMS) (ARIA®, Varian Medical Systems, Palo Alto, California) one can integrate patient check-in at the front desk and identify and open the correct treatment record of the patient at the point of care prior to the initiation of the radiation therapy treatment...
2016: Curēus
https://www.readbyqxmd.com/read/26879995/management-algorithm-for-hiv-associated-parotid-lymphoepithelial-cysts
#20
Waleed F Mourad, Shyamal Patel, Rebekah Young, Azita S Khorsandi, Catherine Concert, Rania A Shourbaji, Katherine Ciarrocca, Richard L Bakst, Daniel Shasha, Chandan Guha, Madhur K Garg, Kenneth S Hu, Shalom Kalnicki, Louis B Harrison
We report an evidence-based management algorithm for benign lymphoepithelial cysts (BLEC) of the parotid glands in HIV patients based on long-term outcomes after radiation therapy. From 1987 to 2013, 72 HIV-positive patients with BLEC of the parotid glands treated at our institutions were identified and their medical records were reviewed and analyzed. The primary endpoint of our study was to determine a dose response in HIV patients with BLEC. In group A (≤18 Gy), which received a median dose of 10 Gy (8-18), overall response (OvR), complete response (CR), partial response (PR), and local failure (LF) was experienced by 7, 7, 0, and 93 %, respectively...
October 2016: European Archives of Oto-rhino-laryngology
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