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https://www.readbyqxmd.com/read/29345324/autocrine-signals-increase-ovine-mesenchymal-stem-cells-migration-through-aquaporin-1-and-cxcr4-overexpression
#1
Alessandra Pelagalli, Anna Nardelli, Enrico Lucarelli, Antonella Zannetti, Arturo Brunetti
Sheep is a relevant large animal model that is frequently used to test innovative tissue engineering (TE) approaches especially for bone reconstruction. Mesenchymal stem cells (MSCs) are used in TE applications because they represent key component of adult tissue repair. Importantly, MSCs from different species show similar characteristics, which facilitated their application in translational studies using animal models. Nowadays, many researches are focusing on the use of ovine mesenchymal stem cells (oMSCs) in orthopedic preclinical settings for regenerative medicine purposes...
January 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29342864/mechanical-properties-of-a-newly-additive-manufactured-implant-material-based-on-ti-42nb
#2
Christian Schulze, Markus Weinmann, Christoph Schweigel, Olaf Keßler, Rainer Bader
The application of Ti-6Al-4V alloy or commercially pure titanium for additive manufacturing enables the fabrication of complex structural implants and patient-specific implant geometries. However, the difference in Young's modulus of α + β-phase Ti alloys compared to the human bone promotes stress-shielding effects in the implant-bone interphase. The aim of the present study is the mechanical characterization of a new pre-alloyed β-phase Ti-42Nb alloy for application in additive manufacturing. The present investigation focuses on the mechanical properties of SLM-printed Ti-42Nb alloy in tensile and compression tests...
January 13, 2018: Materials
https://www.readbyqxmd.com/read/29339568/bone-surface-enhancement-in-ultrasound-images-using-a-new-doppler-based-acquisition-processing-method
#3
Xu Yang, Songyuan Tang, Ennio Tasciotti, Raffaella Righetti
Ultrasound (US) imaging has long been considered as a potential aid in orthopedic surgeries. US technologies are safe, portable and do not use radiations. This would make them a desirable tool for real-time assessment of fractures and to monitor fracture healing. However, image quality of US imaging methods in bone applications is limited by speckle, attenuation, shadow, multiple reflections and other imaging artifacts. While bone surfaces typically appear in US images as somewhat 'brighter' than soft tissue, they are often not easily distinguishable from the surrounding tissue...
January 17, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29335903/anterior-cervical-corpectomy-and-fusion-versus-posterior-laminoplasty-for-the-treatment-of-oppressive-myelopathy-owing-to-cervical-ossification-of-posterior-longitudinal-ligament-a-meta-analysis
#4
Rongqing Qin, Xiaoqing Chen, Pin Zhou, Ming Li, Jie Hao, Feng Zhang
PURPOSE: The purpose of this research is to compare the clinical efficacy, postoperative complication and surgical trauma between anterior cervical corpectomy and fusion versus posterior laminoplasty for the treatment of oppressive myelopathy owing to cervical ossification of the posterior longitudinal ligament (OPLL). STUDY DESIGN: Systematic review and meta-analysis. METHODS: An comprehensive search of literature was implemented in three electronic databases (Embase, Pubmed, and the Cochrane library)...
January 15, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29325704/psychometrics-of-the-patient-reported-outcomes-measurement-information-system-physical-function-instrument-administered-by-computerized-adaptive-testing-and-the-disabilities-of-arm-shoulder-and-hand-in-the-orthopedic-elbow-patient-population
#5
Man Hung, Maren W Voss, Jerry Bounsanga, Yushan Gu, Erin K Granger, Robert Z Tashjian
BACKGROUND: This study evaluated the psychometric properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) instrument administered through computerized adaptive testing (CAT) compared with the traditional full-length Disabilities of the Arm, Shoulder and Hand (DASH). METHODS: The PROMIS PF CAT and the DASH were administered to 1759 patients seeking care for elbow conditions. This study used Rasch partial credit modeling to analyze the instruments with item fit, internal reliability, response category thresholds, dimensionality, local independence, gender differential item functioning, and floor and ceiling effects...
January 9, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29325583/an-integrated-delivery-of-care-approach-to-improve-patient-reported-physical-function-and-mental-wellbeing-after-orthopedic-trauma-study-protocol-for-a-randomized-controlled-trial
#6
Laura Zdziarski-Horodyski, MaryBeth Horodyski, Kalia K Sadasivan, Jennifer Hagen, Terrie Vasilopoulos, Matthew Patrick, Robert Guenther, Heather K Vincent
BACKGROUND: Orthopedic trauma injury impacts nearly 2.8 million people each year. Despite surgical improvements and excellent survivorship rates, many patients experience poor quality of life (QOL) outcomes years later. Psychological distress commonly occurs after injury. Distressed patients more frequently experience rehospitalizations, pain medication dependence, and low QOL. This study was developed to test whether an integrative care approach (IntCare; ten-step program of emotional support, education, customized resources, and medical care) was superior to usual care (UsCare)...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29318944/prevalence-of-iron-deficiency-in-a-total-joint-surgery-population
#7
Jonathan H Waters, Peter Johnson, Mark H Yazer
BACKGROUND: Iron deficiency without anemia has been associated with decreases in functional work capacity and fatigue. The aim of this study was to determine the prevalence of iron deficiency without anemia in a preoperative cohort of orthopedic patients and to determine if iron deficiency is a condition which warrants inclusion into a prehabilitation program prior to surgery. METHODS: One hundred consecutive patients going through preoperative testing for total joint replacement were enrolled in the study...
January 10, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29318124/assessing-medical-tourism-services-quality-using-servqual-model-a-patient-s-perspective
#8
Mohammad Qolipour, Amin Torabipour, Farzad Faraji Khiavi, Amal Saki Malehi
Background: Continuous quality improvement of the hospital services is a basic requirement of medical tourism industry. The different dimensions of hospital services quality are assessed constantly to improve the service of medical tourism. The aim of this study was to determine the services quality of medical tourism in private and public hospitals. Methods: In this cross-sectional study, the quality of hospital services were assessed in view of 250 Iraqi tourists referred to Ahvaz private and public hospitals in 2015...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29315129/relative-contributions-of-adductor-canal-block-and-intrathecal-morphine-to-analgesia-and-functional-recovery-after-total-knee-arthroplasty-a-randomized-controlled-trial
#9
Abhijit Biswas, Anahi Perlas, Meela Ghosh, KiJinn Chin, Ahtsham Niazi, Barjind Pandher, Vincent Chan
BACKGROUND AND OBJECTIVES: Effective postoperative analgesia may enhance early rehabilitation after orthopedic surgery. This randomized double-blind trial investigates the relative contributions of adductor canal block and low-dose intrathecal morphine (ITM) to postoperative analgesia and functional recovery after total knee arthroplasty. METHODS: Two-hundred one patients undergoing elective unilateral total knee arthroplasty under spinal anesthesia were randomized to 3 groups...
January 9, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29315116/minimally-invasive-spine-surgery-analyzing-internet-based-education-material
#10
Jessica Bryant, Rohith Mohan, Brian Koottappillil, Kevin Wong, Paul H Yi
STUDY DESIGN: This is a cross-sectional study. OBJECTIVE: The purpose of this study is to evaluate the content of information available on the Internet regarding minimally invasive spine surgery (MISS). SUMMARY OF BACKGROUND DATA: Patients look to the Internet for quick and accessible information on orthopedic procedures to help guide their personal decision making process regarding the care they receive. However, the quality of internet-based orthopedic education material varies significantly with respect to accuracy and readability...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29311394/exercise-capacity-and-respiratory-profile-in-patients-after-orthopedic-liver-transplantation-a-follow-up-study
#11
Clarissa B A Magalhães, José Huygens P Garcia, Cyntia F G Viana, Maria José N Flor, Pedro Felipe C de Bruin, Eanes D B Pereira
INTRODUCTION: We sought to describe: 1) The influence of orthotopic liver transplantation (OLT) on exercise capacity, pulmonary function and respiratory muscle strength after surgery, 2) The relationship between exercise capacity and symptoms of anxiety and depression. MATERIAL AND METHODS: This is a prospective follow up study conducted with patients submitted to OLT. All patients were assessed before and 1 month after surgery through measurements: six minute walk test (6MWT), 6 min step test (6MST) and HADS (Hospital Anxiety and Depression Scale)...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310418/improvements-in-osteoporosis-testing-and-care-are-found-following-the-wide-scale-implementation-of-the-ontario-fracture-clinic-screening-program-an-interrupted-time-series-analysis
#12
Dorcas E Beaton, Muhammad Mamdani, Hong Zheng, Susan Jaglal, Suzanne M Cadarette, Earl R Bogoch, Joanna E M Sale, Rebeka Sujic, Ravi Jain
We evaluated a system-wide impact of a health intervention to improve treatment of osteoporosis after a fragility fracture. The intervention consisted of assigning a screening coordinator to selected fracture clinics to identify, educate, and follow up with fragility fracture patients and inform their physicians of the need to evaluate bone health. Thirty-seven hospitals in the province of Ontario (Canada) were assigned a screening coordinator. Twenty-three similar hospitals were control sites. All hospitals had orthopedic services and handled moderate-to-higher volumes of fracture patients...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305023/early-vs-late-fracture-fixation-in-severe-head-and-orthopedic-injuries
#13
Yuan Zhang, Kai Sun, Yuling Wang, Yafei Qin, Hui Li
BACKGROUND: Patients suffered from craniocerebral trauma with extermities fracture is one of the most common multiple injuries.Actually there is no comparative study demonstrating advantages of early or delayed treatment of skeletal injuries. PURPOSES: To conduct a meta-analysis with studies published in full text to demonstrate database to show the associations of perioperative, postoperative outcomes of early fracture fixation(EFF) and late fracture fixation(LFF) for patients with severe head and orthopedic injuries to provide the predictive diagnosis for clinic...
December 29, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29300252/a-follow-up-study-of-postoperative-dcm-patients-using-diffusion-mri-with-dti-and-noddi
#14
Xiaodong Ma, Xiao Han, Wen Jiang, Jinchao Wang, Zhe Zhang, Guangqi Li, Jieying Zhang, Xiaoguang Cheng, Huijun Chen, Hua Guo, Wei Tian
STUDY DESIGN: A retrospective cohort study. OBJECTIVE: To investigate the relationship between spinal cord microstructures and spinal cord dysfunction in degenerative cervical myelopathy (DCM) patients, a follow-up study was carried out using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), an advanced diffusion model. SUMMARY OF BACKGROUND DATA: DTI has been used for diagnosis of DCM. Though DTI has advantages of high sensitivity and quantitative features, it is limited by its low specificity for measuring microstructures...
January 3, 2018: Spine
https://www.readbyqxmd.com/read/29299495/first-use-of-a-brief-60-second-mindfulness-exercise-in-an-orthopedic-surgical-practice-results-from-a-pilot-study
#15
Emma Chad-Friedman, Mojtaba Talaei-Khoei, David Ring, Ana-Maria Vranceanu
Background: Mindfulness based interventions may be useful for patients with musculoskeletal conditions in orthopedic surgical practices as adjuncts to medical procedures or alternatives to pain medications. However, typical mindfulness programs are lengthy and impractical in busy surgical practices. We tested the feasibility, acceptability and preliminary effect of a brief, 60-second mindfulness video in reducing pain and negative emotions in patients presenting to an orthopedics surgical practice...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29295590/proposal-of-a-novel-natural-biomaterial-the-scleral-ossicle-for-the-development-of-vascularized-bone-tissue-in-vitro
#16
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone. The current standard treatments include allografting, autografting, and other bone implant techniques. However, although they are commonly used in orthopedic surgery, these treatments have some limitations concerning their costs and their side effects such as potential infections or malunions. On this account, the need for suitable constructs to fill the gap in wide fractures is still urgent...
December 25, 2017: Biomedicines
https://www.readbyqxmd.com/read/29287979/an-evaluation-of-the-biocompatibility-and-osseointegration-of-novel-glass-fiber-reinforced-composite-implants-in-vitro-and-in-vivo-studies
#17
Ya-Hui Chan, Wei-Zhen Lew, Emily Lu, Thomas Loretz, Luke Lu, Che-Tong Lin, Sheng-Wei Feng
OBJECTIVES: The aim of this study was to evaluate the in vitro biocompatibility and in vivo osseointegration of three novel bioactive glass fiber reinforced composite (GFRC) implants and to compare these with metal (Ti6Al4V) implants. METHODS: The surfaces of these experimental substrates were characterized by scanning electron microscopy (SEM), a 2D profilometer and by contact angle measurement. In vitro biological performance was assessed using MG-63 human osteoblast-like cell morphology, cell proliferation assays and the alkaline phosphatase (ALP) activity testing...
December 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29287123/interventions-to-improve-the-outcomes-of-frail-people-having-surgery-a-systematic-review
#18
Daniel I McIsaac, Tim Jen, Nikhile Mookerji, Abhilasha Patel, Manoj M Lalu
BACKGROUND: Frailty is an important prognostic factor for adverse outcomes and increased resource use in the growing population of older surgical patients. We identified and appraised studies that tested interventions in populations of frail surgical patients to improve perioperative outcomes. METHODS: We systematically searched Cochrane, CINAHL, EMBASE and Medline to identify studies that tested interventions in populations of frail patients having surgery. All phases of study selection, data extraction, and risk of bias assessment were done in duplicate...
2017: PloS One
https://www.readbyqxmd.com/read/29286827/the-role-of-anxiety-in-simulation-based-dexterity-and-overall-performance-does-it-really-matter
#19
Fatema Dhaif, Georgios Paparoidamis, Michail Sideris, John Hanrahan, Efstratia-Maria Georgopoulou, Ismini Tsagkaraki, Nikolaos Staikoglou, Ferha Saeed, Theodoros Michail, Anastasios Tzavelas, Efstathios Kenanidis, Michael Potoupnis, Eleftherios Tsiridis, Apostolos Papalois
BACKGROUND: Essential Skills in the Management of Surgical Cases (ESMSC) is an international undergraduate surgical masterclass which combines ex vivo, dry lab and high fidelity in vivo simulation-based learning (SBL). It consists of 32 stations of skills-based learning, including open reduction internal fixation (ORIF) of fractures. Current literature suggests early involvement in skills-based learning at the undergraduate level is vital. AIMS: To compare students' dexterity and skills-based performance with demographic and educational background parameters...
December 29, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29284871/comparative-study-of-clonidine-with-ropivacaine-versus-ropivacaine-alone-in-epidural-anesthesia-for-lower-limb-orthopedic-surgery
#20
Mahendra Singh, Amitesh Pathak, Aamir Laique Khan, Amit Srivastava, Devendra Negi
Background: Epidural anesthesia has been well established as a safe and effective technique not only for perioperative anesthesia but also for postoperative analgesia. Various adjuvants have been added to local anesthetic agent in an effort to prolong this duration. Aims: The aim of this study was to compare and evaluate the anesthesia and analgesic property of ropivacaine to its combination with clonidine for lower limb orthopedic surgery under epidural. Materials and Methods: In a prospective, randomized, double-blind study, eighty adult patients undergoing lower limb surgeries received either 0...
October 2017: Anesthesia, Essays and Researches
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