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https://www.readbyqxmd.com/read/29664916/is-periodontitis-a-risk-indicator-for-cancer-a-meta-analysis
#1
Stefano Corbella, Paolo Veronesi, Viviana Galimberti, Roberto Weinstein, Massimo Del Fabbro, Luca Francetti
BACKGROUND: The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer. METHODS: Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis. RESULTS: Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies...
2018: PloS One
https://www.readbyqxmd.com/read/29663705/bronchial-brush-cytology-of-primary-anaplastic-large-cell-lymphoma-of-lung
#2
Meyyappa Devan Rajagopal, Debasis Gochhait, Bheemanathi Hanuman Srinivas, Rajesh Nachiappa Ganesh, Neelaiah Siddaraju, Manju Rajaram
Primary pulmonary lymphoma is defined as clonal lymphoid proliferation affecting one or both lungs in a patient with no extrapulmonary involvement at the time of diagnosis or during the subsequent 3 months. Anaplastic large cell lymphoma (ALCL) is a rare T-cell neoplasm which occurs as two distinct clinical entities-cutaneous and systemic variant. Primary lung involvement is extremely uncommon. It can be classified on the basis of being positive or negative for ALK rearrangement which carries prognostic significance...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29662529/neoadjuvant-chemotherapy-in-locally-advanced-duodenal-adenocarcinoma
#3
Carlos Velandia, Rafael Delgado Morales, Carlos Coello, Armando Gil Mendoza, Gabriel Pérez, Emperatriz Aguero
Duodenal adenocarcinoma (ADC) represents only 0.3% of gastrointestinal neoplasms. With the frequency being higher between the ages of 40 and 60, it is predominantly located in the second part of the duodenum and around the periampullary region. Symptoms are nonspecific, so the majority of patients present with advanced disease. Neoadjuvant chemotherapy is a therapeutic option that has not been well studied. The global literature includes only isolated reports on this subject. This is why we are presenting the following case: a 60-year-old female patient with a locally advanced, inoperable duodenal ADC received neoadjuvant chemotherapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29659398/mixed-epithelial-and-stromal-tumor-of-the-kidney-mimicking-malignancy-on-18f-fdg-pet-ct-in-a-patient-with-breast-cancer
#4
Chongjiao Li, Yueli Tian, Meijuan Shen, Bing Wen, Yong He
Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare renal tumor composed of solid and cystic components. Mixed epithelial and stromal tumor of the kidney has no pathognomonic imaging feature. It is difficult to distinguish MESTK from other cystic renal neoplasms using current radiological methods. We report a rare case of MESTK that was diagnosed in a 46-year-old woman with breast cancer. F-FDG PET/CT and contrast-enhanced CT features of MESTK are presented, which could potentially provide useful information in the differential diagnoses of cystic renal neoplasms...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#5
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29651355/cutaneous-adnexal-cylindroma-of-breast-epithelial-immunoreactivities-for-gata-3-mammaglobin-and-e-cadherin-do-not-equate-to-a-mammary-ductal-neoplasm
#6
A Halima, A M Pannunzio, E M Erstine, J S Ko, W F Bergfeld, R M Malaya, M B Frankel, B C Calhoun, C D Sturgis
Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. In the current case, a cylindroma of the skin of the breast was diagnosed by complete excision. Immunohistochemical studies confirmed the tumor cells to be immunoreactive with cytokeratin AE1/3, cytokeratin 5/6, cytokeratin 7, p63, and SOX10. The neoplastic cells were also noted to be immunoreactive with markers typically expected to be positive in ductal epithelium of the breast including GATA3, mammaglobin, and E-cadherin...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29629144/label-free-raman-spectroscopy-provides-early-determination-and-precise-localization-of-breast-cancer-colonized-bone-alterations
#7
Chi Zhang, Paul T Winnard, Sidarth Dasari, Scott L Kominsky, Michele Doucet, Swaathi Jayaraman, Venu Raman, Ishan Barman
Breast neoplasms frequently colonize bone and induce development of osteolytic bone lesions by disrupting the homeostasis of the bone microenvironment. This degenerative process can lead to bone pain and pathological bone fracture, a major cause of cancer morbidity and diminished quality of life, which is exacerbated by our limited ability to monitor early metastatic disease in bone and assess fracture risk. Spurred by its label-free, real-time nature and its exquisite molecular specificity, we employed spontaneous Raman spectroscopy to assess and quantify early metastasis driven biochemical alterations to bone composition...
January 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29617282/inhibiting-trk-proteins-in-clinical-cancer-therapy
#8
REVIEW
Allison M Lange, Hui-Wen Lo
Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer therapeutics. The TRK family contains three members, TRKA, TRKB, and TRKC, and these proteins are encoded by the genes NTRK1, NTRK2, and NTRK3, respectively. To activate TRK receptors, neurotrophins bind to the extracellular region stimulating dimerization, phosphorylation, and activation of downstream signaling pathways...
April 4, 2018: Cancers
https://www.readbyqxmd.com/read/29603332/solid-papillary-breast-carcinomas-resembling-the-tall-cell-variant-of-papillary-thyroid-neoplasms-solid-papillary-carcinomas-with-reverse-polarity-harbor-recurrent-mutations-affecting-idh2-and-pik3ca-a-validation-cohort
#9
John R Lozada, Thais Basili, Fresia Pareja, Barbara Alemar, Arnaud C Paula, Rodrigo Gularte-Merida, Dilip D Giri, Patrizia Querzoli, Gabor Cserni, Emad A Rakha, Maria Pia Foschini, Jorge S Reis-Filho, Edi Brogi, Britta Weigelt, Felipe C Geyer
AIMS: Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histologic type of breast cancer that morphologically resembles the tall cell variant of papillary thyroid carcinoma. BPTCs are characterized by IDH2 R172 hotspot somatic mutations or mutually exclusive TET2 somatic mutations, concurrently with mutations affecting PI3K pathway-related genes. We sought to characterize their histology, and investigate the frequency of IDH2 and PIK3CA mutations in an independent cohort of BPTCs, as well as in conventional solid papillary carcinomas (SPCs)...
March 30, 2018: Histopathology
https://www.readbyqxmd.com/read/29597131/health-related-quality-of-life-and-utility-scores-of-patients-with-breast-neoplasms-in-china-a-multicenter-cross-sectional-survey
#10
Le Wang, Ju-Fang Shi, Juan Zhu, Hui-Yao Huang, Ya-Na Bai, Guo-Xiang Liu, Xian-Zhen Liao, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Lan-Wei Guo, Yi Fang, Qi Zhou, Heng-Min Ma, Xiao-Jing Xing, Lin Zhu, Bing-Bing Song, Ling-Bin Du, Ling Mai, Yu-Qin Liu, Ying Ren, Li Lan, Jin-Yi Zhou, Xiao Qi, Xiao-Hua Sun, Pei-An Lou, Shou-Ling Wu, Ni Li, Kai Zhang, Jie He, Min Dai
BACKGROUND: Health-related quality of life and utility scores of patients with breast cancer and precancerous lesions are sparse in China. This study aimed to derive utility scores of patients with breast cancer and precancer in China. MATERIAL AND METHODS: An interviewer-administered cross-sectional survey was conducted in 12 provinces across China from 2013 to 2014. The three-level EuroQol-5-Dimension instrument was used to evaluate quality of life, and utility scores were generated using the Chinese value set...
March 26, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29595104/association-of-metronidazole-with-cancer-a-potential-risk-factor-or-inconsistent-deductions
#11
Muhammad Adil, Waheed Iqbal, Fazal Adnan, Shabnam Wazir, Imran Khan, Mohammad Umar Khayam, Mohammad Amjad Kamal, Shafiq Ahmad, Jawad Ahmad, Ishaq N Khan
Metronidazole is a synthetic derivative of nitroimidazole that has been widely used for the treatment of several bacterial and protozoal parasitic infections including trichomoniasis, amoebiasis, giardiasis, liver abscess, acute ulcerative gingivitis, syphilis and tropical phagedena. In addition to its toxicity in the gastrointestinal tract and central/peripheral nervous system, metronidazole has been reported to cause mucosal imbalance by affecting the expression of mucin (Muc2 gene), which is responsible to form an insoluble mucous barrier that protects the gut lumen from microbial colonization...
March 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29594054/a-case-report-of-syndromic-multinodular-goitre-in-adolescence-exploring-the-phenotype-overlap-between-cowden-and-dicer1-syndromes
#12
Dorothée Bouron-Dal Soglio, Leanne de Kock, Richard Gauci, Nelly Sabbaghian, Elizabeth Thomas, Helen C Atkinson, Nicholas Pachter, Simon Ryan, John P Walsh, M Priyanthi Kumarasinghe, Karen Carpenter, Ayça Aydoğan, Colin J R Stewart, William D Foulkes, Catherine S Choong
Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome. Material and Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Fine needle cytology of the thyroid revealed a follicular neoplasm with features suggestive of follicular variant of papillary thyroid carcinoma and she underwent a hemithyroidectomy...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29580045/thirty-years-cancer-incidence-data-for-lahore-pakistan-trends-and-patterns-1984-2014
#13
Andleeb Masood, Khalid Masood, Mazhar Hussain, Waqar Ali, Masooma Riaz, Zafar Alauddin, Munir Ahmad, Misbah Masood, Abubaker Shahid
This research was conducted to generate trends and patterns of most common male and female cancers from 1984-2014 for the city population of Lahore Pakistan. Cancer incidence data gathered for different organs were processed through cleaning, integration, transformation, reduction and mining for ultimate representation. Risk of cancer appeared to be continuously increasing among both males and females. Overall, lymphomas and breast cancer are the most common neoplasm in males and females, respectively, in Lahore with almost the highest rates in the Asian Pacific region...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29573619/estrogen-the-necessary-evil-for-human-health-and-ways-to-tame-it
#14
REVIEW
Seema Patel, Ahmad Homaei, Akondi Butchi Raju, Biswa Ranjan Meher
Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum, tropism, tissue-specific distribution, and receptor affinity varies with different phases of life. Converted from androgen via aromatase enzyme, this hormone is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, fertility, and neural functions. However, estrogen is at the center of almost all human pathologies as well-infectious, autoimmune, metabolic to degenerative. Both hypo and hyper level of estrogen has been linked to chronic and acute diseases...
March 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29566711/rising-global-burden-of-breast-cancer-the-case-of-sub-saharan-africa-with-emphasis-on-nigeria-and-implications-for-regional-development-a-review
#15
REVIEW
Samuel O Azubuike, Colin Muirhead, Louise Hayes, Richard McNally
BACKGROUND: Despite mortality from breast cancer in Africa being higher than in high income countries, breast cancer has not been extensively studied in the region. The aim of this paper was to highlight the rising burden of breast cancer with an emphasis on sub-Saharan Africa as well as trends, characteristics, controversies and their implications for regional development. METHODOLOGY: A review of published studies and documents was conducted in Medline, Scopus, Pubmed and Google using combinations of key words-breast neoplasm, breast cancer, cancer, incidence, mortality, Africa, Nigeria...
March 22, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29564332/occurrence-of-occult-malignancies-in-reduction-mammoplasties
#16
Matthias Waldner, Holger J Klein, Walter Künzi, Merlin Guggenheim, Jan A Plock, Pietro Giovanoli
Objectives: Patients undergoing reduction mammoplasty (RM) bear the risk of having occult breast cancer nests. The detection rate of malignant neoplasms in the resected specimens, varies greatly in the literature. The aim of our present study was to analyze risk factors and evaluate histopathological findings in our cohort of patients who underwent RM towards our center. Material and methods: In this retrospective single center study we analyzed 559 female patients [median age 35...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29563635/in-breast-cancer-subtypes-steroid-sulfatase-sts-is-associated-with-less-aggressive-tumour-characteristics
#17
Keely M McNamara, Fouzia Guestini, Torill Sauer, Joel Touma, Ida Rashida Bukholm, Jonas C Lindstrøm, Hironobu Sasano, Jürgen Geisler
BACKGROUND: The majority of breast cancer cases are steroid dependent neoplasms, with hormonal manipulation of either CYP19/aromatase or oestrogen receptor alpha axis being the most common therapy. Alternate pathways of steroid actions are documented, but their interconnections and correlations to BC subtypes and clinical outcome could be further explored. METHODS: We evaluated selected steroid receptors (Androgen Receptor, Oestrogen Receptor alpha and Beta, Glucocorticoid Receptor) and oestrogen pathways (steroid sulfatase (STS), 17β-hydroxysteroid dehydrogenase 2 (17βHSD2) and aromatase) in a cohort of 139 BC cases from Norway...
March 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29558027/clinicopathological-features-of-metaplastic-breast-carcinoma
#18
Oğuz Ahmet Hasdemir, Serhat Tokgöz, Fulya Köybaşıoğlu, Harun Karabacak, Cüneyt Yücesoy, Gökşen İnanç İmamoğlu
BACKGROUND: Metaplastic carcinoma of the breast (MpBC) is defined as a group of heterogeneous malignant neoplasms that contain glandular and non-glandular components with mixed epithelial and mesenchymal differentiations. OBJECTIVES: The aim of this study was to research the clinical and pathological characteristics of MpBC determining its rank among all breast cancers. MATERIAL AND METHODS: Metaplastic carcinoma of the breast was found in 7 out of 1,164 patients who had been diagnosed with breast cancer within the period of 12 years in our hospital...
March 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29556390/squamous-cell-carcinoma-of-the-breast-as-a-clinical-diagnostic-challenge
#19
Katarzyna Jakubowska, Luiza Kańczuga-Koda, Wojciech Kisielewski, Mariusz Koda, Waldemar Famulski
Squamous cell carcinoma (SqCC) of the breast should be differentiated between the primary skin keratinizing squamous carcinoma and squamous metaplastic cancer. In the current study, the cases of two patients who were diagnosed with SqCC originated from skin and the breast were discussed. A fine-needle aspiration biopsy confirmed the presence of atypical squamous cells. In both cases, the microscopic examination of the surgical specimen revealed a malignant neoplasm differentiated into SqCC characterized by keratinizing cancer cells with abundant eosiphilic cytoplasm with large, hyperchromatic vesicular nuclei...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29554092/increasing-negative-lymph-node-count-predicts-favorable-os-and-dss-in-breast-cancer-with-different-lymph-node-positive-subgroups
#20
Xin Zhao, Jing Wei, Xiaoxin Li, Haochang Yang, Pei Wang, Susheng Cao
Adequate lymph node evaluation is recommended for optimal staging in patients with malignant neoplasms including breast cancer. However, the role of negative lymph nodes (LNs) remains unclear in breast cancer according to N substage (N1, N2, and N3). In this study, for the first time, we analyzed the prognostic significance of negative LNs in breast cancer patients. A critical relationship was observed between negative LN count and survival, independent of patient characteristics and other related molecular variables including estrogen receptor (PR) status, progesterone receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, depth of tumor invasion and degree of differentiation...
2018: PloS One
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