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Breast neoplasms

Jing Zhang, Xiaochen Zhang, Yanan Li, Zhenzhen Zhou, Chuanlong Wu, Zhiyan Liu, Lanxiang Hao, Shanshan Fan, Fang Jiang, Yan Xie, Ling Jiang
Thyroid carcinoma (TC) is the most common endocrine neoplasm. The risk of TC as a second primary malignancy (SPM) of breast cancer is significantly increased. Bisphenol A (BPA) is a widely contacted xenoestrogen and increases susceptibility to breast cancer through binding to estrogen receptor alpha (ERα). However, the effect of BPA on thyroid carcinogenesis has not been fully demonstrated. This present study aimed to characterize the effects of BPA on the development of TC using a Fischer 344 (F344) rat model...
September 19, 2017: Oncotarget
Catherine Genestie, Alexandra Leary, Mojgan Devassoux-Shisheboran, Aurélie Auguste
Endometrial cancer is the fourth cause of cancer in women in France and is the second most common cancer of the gynecologic cancer after breast cancer with 7275 new cases in 2012. The incidence of this neoplasm tends to increase with population aging, diabetes and obesity's augmentation. In rare cases, a hereditary factor has been described: Lynch's syndrome. The therapeutic management of the patient depends on the endometrial biopsy which specifies the histological type and the histo-prognostic grade as well as the MRI which allow the tumor staging...
October 11, 2017: Bulletin du Cancer
Ruffo de Freitas, Rodrigo Disconzi Nunes, Edesio Martins, Maria Paula Curado, Nilceana Maya Aires Freitas, Leonardo Ribeiro Soares, José Carlos Oliveira
OBJECTIVE: to analyze the overall survival and prognostic factors of women with breast cancer in the city of Goiânia. METHODS: this is a retrospective, cross-sectional, observational study that included women with malignant neoplasms of the breast identified by the Goiânia Population-based Cancer Registry. The variables studied were age at diagnosis, tumor size, staging, axillary lymph node involvement, tumor grade, disease extent, hormone receptors, and c-erb-B2 oncoprotein...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
Nada A S Alwan, Faisal H Mualla, Munawar Al Naqash, Saad Kathum, Furat N Tawfiq, Sana Nadhir
BACKGROUND: Breast cancer is the most common malignancy affecting the Iraqi population and the leading cause of cancer related mortality among Iraqi women. It has been well documented that prognosis of patients depends largely upon the hormone receptor contents and HER-2 over expression of their neoplasm. Recent studies suggest that Triple Positive (TP) tumors, bearing the three markers, tend to exhibit a relatively favorable clinical behavior in which overtreatment is not recommended...
September 2017: Gulf Journal of Oncology
Salah Fayaz, Gerges Attia Demian, Heba El-Sayed Eissa, Sadeq Abuzalouf
OBJECTIVES: To review the clinico-epidemiologic characteristics of patients who presented with two or more primary cancers, one of which was breast cancer (BC) and to develop a follow-up program for the high risk patients. PATIENTS AND METHODS: Patients who were diagnosed with BC and one or more non breast cancer (NBC) were retrospectively reviewed. Medical files were retrieved and epidemiological as well as clinical data were analyzed. RESULTS: Sixty-two patients were retrieved...
September 2017: Gulf Journal of Oncology
Thomas Mentzel, Katalin Kiss
The diagnosis of radiation-associated angiosarcoma is challenging and there are overlapping clinicopathological features between radiation-associated benign, atypical and malignant vascular lesions. It has been shown convincingly, that the majority of radiation-associated angiosarcomas are characterised by amplification and subsequent overexpression of MYC in contrast to benign and atypical vascular lesions. Given the fact that epigenetic changes play an important role in carcinogenesis and loss of histone H3K27 trimethylation (H3K27me3) has been found in a number of malignant neoplasms including malignant peripheral nerve sheath tumours, especially when associated with previous radiotherapy, we evaluated the immunohistochemical reaction pattern for H3K27me3 in 49 vascular lesions and control cases: normal skin and benign vascular lesions not associated with previous radiotherapy, radiation-associated benign, atypical and malignant vascular lesions and angiosarcomas not associated with previous radiotherapy...
October 5, 2017: Virchows Archiv: An International Journal of Pathology
Alberto Testori, Marco Alloisio, Valentina Errico, Edoardo Bottoni, Emanuele Voulaz, Bethania Fernandez, Stefano Meroni, Matilde De Simone, Ugo Cioffi
BACKGROUND: Pseudoangiomatous stromal hyperplasia is an uncommon mesenchymal breast neoplasm. CASE PRESENTATION: Here we present a case of an 11-year old hispanic girl affected by bilateral mammary nodular pseudoangiomatous stromal hyperplasia, an uncommon breast disease, with a review of the literature related to diagnostic workup, differential diagnosis, and management. A rapidly growing mass in the breast may be stressful for both parents and child as the suspicion of malignancy arises...
October 5, 2017: Journal of Medical Case Reports
Camila Soares Lima Corrêa, Luanna Couto Pereira, Isabel Cristina Gonçalves Leite, Vívian Assis Fayer, Maximiliano Ribeiro Guerra, Maria Teresa Bustamante-Teixeira
OBJECTIVE: to assess the results of indicators related to the supply of mammography and level of adequacy of diagnostic confirmation for mammograms with suspicious findings of malignancy in Minas Gerais state and its health macroregions. METHODS: this is an evaluation study performed with data from the Breast Cancer Information System and the Outpatient Information System for the years 2010 and 2011. RESULTS: : the ratio of mammograms in women aged 50 to 69 years was of 0...
July 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Melike Doğanay, Hasan Onur Topçu, Mahmut Kuntay Kokanalı, Ali I Rfan Güzel, Aslı Oskovi, Serap Akbay, Sabri Cavkaytar
The ovaries are common site of metastasis in a variety of primary neoplasms. Multiple tumors such as breast, lung, and pancreas have been reported to metastasize to the ovary, however; the colon and stomach are the most common primary cancer sites that of ovarian metastasis. An ovarian mass mostly originates from its self-tissue, but sometimes it can be a metastasis of a gastrointestinal system tumor. Such cases are often misdiagnosed as primary ovarian cancers. A 42-year-old woman was admitted to our hospital with pelvic pain...
September 2017: Journal of Experimental Therapeutics & Oncology
Alaa Alsadi, Dianna Lin, Hussein Alnajar, Arlen Brickman, Colin Martyn, Paolo Gattuso
OBJECTIVES: Hematological malignancies of the breast share a presentation similar to primary breast carcinomas but differ substantially in therapeutic approach and clinical outcomes. In this study, we investigate the frequency of hematological malignancies, their relative primary and secondary occurrences, and further characterize the distinct histopathologies of these malignancies with a special focus on lymphomas. To our knowledge this is one of the largest and most comprehensive studies of breast hematologic malignancies...
October 2017: Southern Medical Journal
Patricia Mjønes, Liv Sagatun, Ivar S Nordrum, Helge L Waldum
The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being a cytosolic marker may be useful in this setting. NSE is by many considered nonspecific, due to the finding of this marker in tumors considered not to be of neuroendocrine origin. Our aim was to determine whether this is true and whether NSE is more specific than previously realized. We examined 178 tumors (carcinomas and NENs) from breast, lung, stomach, and kidney using immunohistochemistry with the following markers: chromogranin A, synaptophysin, CD56, secretagogin, and NSE...
September 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
Hee Chan Jung, Sung Hwan Kim, Jeong Hoon Lee, Ju Han Kim, Sung Won Han
PURPOSE: To better identify the physiology of triple-negative breast neoplasm (TNBN), we analyzed the TNBN gene regulatory network using gene expression data. METHODS: We collected TNBN gene expression data from The Cancer Genome Atlas to construct a TNBN gene regulatory network using least absolute shrinkage and selection operator regression. In addition, we constructed a triple-positive breast neoplasm (TPBN) network for comparison. Furthermore, survival analysis based on gene expression levels and differentially expressed gene (DEG) analysis were carried out to support and compare the network analysis results, respectively...
September 2017: Journal of Breast Cancer
Yingli Zhong, Ping Xuan, Xiao Wang, Tiangang Zhang, Jianzhong Li, Yong Liu, Weixiong Zhang
Motivation: Identification of disease-associated miRNAs (disease miRNAs) is critical for understanding disease etiology and pathogenesis. Since miRNAs exert their functions by regulating the expression of their target mRNAs, several methods based on the target genes were proposed to predict disease miRNA candidates. They achieved only limited success as they all suffered from the high false-positive rate of target prediction results. Alternatively, other prediction methods were based on the observation that miRNAs with similar functions tend to be associated with similar diseases and vice versa...
September 1, 2017: Bioinformatics
Stefano Cavalieri, Anastasios Stathis, Alessandra Fabbri, Angelica Sonzogni, Federica Perrone, Elena Tamborini, Giuseppe Pelosi, Filippo de Braud, Marco Platania
INTRODUCTION: NUT midline carcinoma (NMC) is a rare and aggressive epithelial cancer arising from median organs. It is driven by chromosomal translocation t(15;19) involving the rearrangement of NUT (nuclear protein in testis) and BRD4 (bromodomain 4) genes leading to fusion oncoprotein BRD4-NUT. CASE PRESENTATION: We report the case of a woman who was previously treated with induction chemotherapy, surgery, radiotherapy and adjuvant trastuzumab for HER-2 positive invasive ductal carcinoma of the breast...
September 25, 2017: Tumori
Alaaddin M Salih, Dafallah M Alam-Elhuda, Musab M Alfaki, Adil E Yousif, Momin M Nouradyem
BACKGROUND: Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk factors that exist between different races, we therefore aimed to develop and validate a tool for breast cancer risk assessment among Sudanese women. METHODS: Using cross-sectional design, 153 subjects were eligible to participate in our study...
September 29, 2017: European Journal of Medical Research
Anna Brzozowska, Franciszek Burdan, Dariusz Duma, Janusz Solski, Maria Mazurkiewicz
INTRODUCTION: The γ-amino butyric acid (GABA) plays important role in the proliferation and migration of cancer cells. The aim of the study was to evaluate the level of GABA in breast cancer, in relation to clinical and epidemiological data. MATERIAL AND METHODS: The study was conducted on 89 patients with breast cancer in stage I-II. GABA level was assessed using spectrofluorometric method in tumour homogenates. Immunoexpression of E-cadherin was evaluated histologically on paraffin fixed specimens...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
X Han, M Q Ouyang, Q Pei, M H Duan, X Y Jiang, D B Zhou
Objective: To explore the clinical characteristics, treatment, and prognosis of patients with blastic plasmacytoid dendritic cell neoplasm. Method: Clinical records of 6 patients diagnosed with blastic plasmacytoid dendritic cell neoplasm in our hospital from January 2008 to May 2016 were collected and retrospectively analyzed. Results: Six patients manifested with initial symptoms of skin lesions, other common symptoms included bone marrow involvement (5/6) , lymphadenectasis (4/6) , splenomegaly (4/6) , and hepatomegaly (3/6) ...
August 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
José Ramón Germá-Lluch, Lourdes Petriz, Pau Lopez, Esther Asensio
BACKGROUND AND OBJECTIVE: Five years' data relative survival (RS) is presented in 3 solid tumours: breast, colorectal (CRC) and lung and 2 haematologic neoplasms: large B cell lymphoma (NHL-B) and multiple myeloma (MM) treated at Institut Català d'Oncologia between 2010-2011 in comparison with the results obtained in a historical special cohort from 1998-1999. MATERIAL AND METHODS: A database was created in a common safe and accessible repository. We have introduced more than 5,000 medical records...
September 22, 2017: Medicina Clínica
Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda, Guido Hildebrandt
BACKGROUND: As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary malignant neoplasms might be significantly increased due to exposure of healthy tissue outside of the target field to secondary neutrons, in particular in proton therapy. Thus far, the radiobiological effects of these neutrons and a comparison with photons on normal breast cells have not been sufficiently characterised...
September 25, 2017: Radiation Oncology
Aurélie Maran-Gonzalez
No abstract text is available yet for this article.
October 2017: Annales de Pathologie
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