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Breast neoplasms

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https://www.readbyqxmd.com/read/29436596/homeobox-protein-msx1-inhibits-the-growth-and-metastasis-of-breast-cancer-cells-and-is-frequently-silenced-by-promoter-methylation
#1
Yujuan Yue, Ying Yuan, Lili Li, Jiangxia Fan, Chen Li, Weiyan Peng, Guosheng Ren
Deregulation of msh homeobox 1 (MSX1) has been identified to be associated with multiple human malignant neoplasms. However, the association of the expression and biological function of MSX1 with breast tumorigenesis, and the underlying mechanism remain largely unknown. Therefore, the present study examined the expression and promoter methylation of MSX1 in breast tumor cell lines, primary breast tumors and normal breast tissues using semi-quantitative, quantitative and methylation-specific reverse transcription‑polymerase chain reaction...
February 7, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29434864/effect-of-matrine-against-breast-cancer-by-downregulating-the-vascular-endothelial-growth-factor-via-the-wnt-%C3%AE-catenin-pathway
#2
Xu Xiao, Man Ao, Fan Xu, Xiao Li, Jiuli Hu, Ying Wang, Daixiao Li, Xiaoqin Zhu, Chunlan Xin, Wenda Shi
The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF-7 cells in a dose- and time-dependent manner in vitro. In addition, matrine suppressed the 4T1-tumor growth, induced apoptosis, inhibited the expression of vascular endothelial growth factor and downregulated the Wnt/β-catenin signaling pathway in vivo...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434343/differential-expression-patterns-of-gata3-in-usual-and-differentiated-types-of-vulvar-intraepithelial-neoplasia-potential-diagnostic-implications
#3
Abha Goyal, Gloria Zhang, Bin Yang
The two main precursors of vulvar squamous cell carcinoma, usual and differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, pathogenesis, and natural history. Usual type VIN is often associated with high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor that shows increased expression in several types of human malignancies including breast and bladder carcinomas. Little is known regarding the expression of GATA3 in vulvar squamous neoplasms...
February 13, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29431200/gata-3-staining-in-primary-cutaneous-apocrine-cribriform-carcinoma-usefulness-to-differentiate-it-from-breast-cancer-metastasis
#4
M Llamas-Velasco, Y C Pérez-Gónzalez, E Daudén, A Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raise a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. DESIGN: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test this immunostaining usefulness to differentiate this tumor from metastatic breast cancer...
February 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29423555/second-malignancies-after-hematopoietic-stem-cell-transplantation
#5
REVIEW
Ivetta Danylesko, Avichai Shimoni
Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarcinomas and with chronic graft-versus-host disease which is associated with squamous cell cancers...
February 8, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29413655/a-diagnostic-approach-to-fibroepithelial-breast-lesions
#6
REVIEW
Benjamin Yongcheng Tan, Puay Hoon Tan
Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. Fibroadenomas are common benign neoplasms that may be treated conservatively. Phyllodes tumors are relatively rare lesions, and classified as benign, borderline, or malignant based on histologic evaluation of various parameters. The diagnostic interpretation of "gray-zone" fibroepithelial lesions often imposes formidable demands on a pathologist's skills...
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29410346/pathologic-upgrade-rates-of-high-risk-breast-lesions-on-digital-2-dimensional-vs-tomosynthesis-mammography
#7
Leslie R Lamb, Manisha Bahl, Kevin S Hughes, Constance D Lehman
BACKGROUND: To compare the pathologic upgrade rates of high-risk breast lesions (HRLs) on digital 2D mammography (DM) versus digital breast tomosynthesis (DBT). STUDY DESIGN: The study cohort was composed of patients with HRLs diagnosed by image-guided core needle biopsy from December 2007 to February 2011 (DM group, before DBT integration) and from January 2013 to March 2016 (DBT group, after complete DBT integration). Medical records were reviewed for surgical outcomes and follow-up imaging...
February 1, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29409947/de-escalating-systemic-therapy-in-triple-negative-breast-cancer-the-example-of-secretory-carcinoma
#8
Julie-Charlotte Benabu, François Stoll, Antoine Koch, Sébastien Molière, Jean-Pierre Bellocq, Carole Mathelin
Triple negative breast cancers have the highest relapse risk and the least favourable prognosis of all breast cancer subtypes, leading to an escalation of chemotherapy, substantially during recent years. Secretory carcinoma of the breast is a rare triple negative neoplasm, first described in children but more often presenting in adults. We report a case of a 70-years-old woman, initially diagnosed on the biopsy with a triple negative infiltrating NOS (Not Otherwise Specified) carcinoma of the breast, before it was later correctly identified as a secretory carcinoma, notably because of an abundant intra and extracellular secretory material...
January 30, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29405995/survey-of-gynecological-carcinosarcomas-in-families-with-breast-and-ovarian-cancer-predisposition
#9
Carla B Ripamonti, Siranoush Manoukian, Bernard Peissel, Jacopo Azzollini, Maria Luisa Carcangiu, Paolo Radice
Carcinosarcomas (CSs) are biphasic neoplasms composed of high grade, malignant, epithelial and mesenchymal elements. The incidence of gynecological CSs (GCSs) is 0.4/100,000 women per year. Patients affected with GCSs have been occasionally reported in Hereditary Breast Ovarian Cancer (HBOC) families, including a few cases with pathogenic variants in BRCA1/BRCA2 genes. The prevalence and the association of GCSs in HBOC families have not been systematically investigated. Thus, we searched for families with GCSs in the HBOC registry of the National Cancer Institute of Milan...
February 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29403218/fine-needle-aspiration-cytology-of-granulocytic-sarcoma-presenting-as-a-breast-lump-report-of-a-rare-case-with-a-comprehensive-literature-search
#10
Abhishek Sharma, Anjan Kr Das, Subrata Pal, Subodh Bhattacharyya
Myeloid sarcoma is a neoplasm of myeloid cells that can arise before or concurrent with or may follow acute myeloid leukemia. Very rarely, it can present as an isolated breast lump. We have diagnosed a case of myeloid sarcoma by fine-needle aspiration cytology (FNAC), in a 52-year-old woman who presented with the right-sided breast lump. FNAC showed hypercellular smears with immature myeloid cells few neutrophils and many large round cells with high nuclear-cytoplasmic ratio, prominent nucleoli and a moderate amount of granular cytoplasm...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29397622/-current-situation-and-prospect-of-breast-cancer-liquid-biopsy
#11
B Zhou, L Xin, L Xu, J M Ye, Y H Liu
Liquid biopsy is a diagnostic approach by analyzing body fluid samples. Peripheral blood is the most common sample. Urine, saliva, pleural effusion and ascites are also used. Now liquid biopsy is mainly used in the area of neoplasm diagnosis and treatment. Compared with traditional tissue biopsy, liquid biopsy is minimally invasive, convenient to sample and easy to repeat. Liquid biopsy mainly includes circulating tumor cells and circulating tumor DNA (ctDNA) detection. Detection of ctDNA requires sensitive and accurate methods...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29385322/sox10-keratin-dual-color-immunohistochemistry-an-effective-first-line-test-for-the-workup-of-epithelioid-malignant-neoplasms-in-fna-and-small-biopsy-specimens
#12
Jeffrey K Mito, James R Conner, Jason L Hornick, Edmund S Cibas, Xiaohua Qian
BACKGROUND: The characterization of poorly differentiated neoplasms in fine-needle aspiration (FNA) and small biopsy specimens usually requires immunohistochemistry (IHC) with a panel of markers. Because of an increasing need to preserve limited diagnostic material for tumor genotyping and a mounting demand for cost containment, the authors investigated the usefulness of dual-color IHC with antibodies directed against broad-spectrum keratins and SOX10, a neuroectodermal transcription factor consistently expressed in melanoma, in the workup of epithelioid malignant neoplasms...
January 31, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29384187/investigating-the-levels-of-soluble-extracellular-domain-of-her2-protein-in-the-sera-of-meningioma-patients
#13
Shabnam Abtahi, Sareh Hakimrabet, Mahyar Malekzadeh, Amir Reza Deghanian, Abbas Ghaderi
AIM: Meningiomas are the most frequently diagnosed primary central nervous system (CNS) neoplasms. Considering slightly higher incidence of meningiomas in breast cancer patients and breast cancer in meningioma patients, it can be assumed that both tumors share similar risk factors. HER2 gene amplification and/or over-expression have been found in several human cancers, but it has been most widely studied in breast carcinomas. Bearing in mind the association of breast cancer and meningioma, the present study aimed to investigate the levels of the soluble extracellular domain of HER2 protein in meningioma cases and control group...
December 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29382006/pure-acinic-cell-carcinoma-of-the-breast-a-case-report-and-literature-review
#14
Hongmei Li, Fuzhi Wang, Pingrong Shen, Feng Zhou
RATIONALE: Acinic cell carcinoma (AcCC) of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. PATIENT CONCERNS: A 52-year-old woman presented to the hospital with a palpable mass over the upper outer quadrant of the right breast. DIAGNOSES: Physical examination revealed an irregular mass in the lateral upper quadrant of the left breast, approximately 1.5 cm in diameter. Histologically, the tumor cells were round to oval, had displaced nuclei with striking single nucleoli and basophilic cytoplasm, and contained large coarse cytoplasmic granules...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375904/chest-wall-a-structure-underestimated-in-ultrasonography-part-iii-neoplastic-lesions
#15
REVIEW
Andrzej Smereczyński, Katarzyna Kołaczyk, Elżbieta Bernatowicz
Chest wall neoplasms mainly include malignancies, metastatic in particular. Differential diagnosis should include clinical data; tumor location, extent, delineation; the degree of homogeneity; the presence of calcifications; the nature of bone destruction and the degree of vascularization. The aim of the paper is to present both the benefits and limitations of ultrasound for the diagnosis of chest wall neoplasms. The neoplastic process may be limited to the chest wall; it may spread from the chest wall into the intrathoracic structures or spread from the inside of the chest towards the chest wall...
December 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29373872/depression-in-women-with-breast-cancer-a-systematic-review-of-cross-sectional-studies-in-iran
#16
Azar Jafari, Amir Hossein Goudarzian, Masoumeh Bagheri Nesami
Objective: Breast cancer is one of the most common cancers in women and has more severe mental and emotional effects than other types. Depression as a mental disorder affects people’s mental well-being, physical symptoms, occupational performance, and finally quality of life. The aim of this study was to determine depression levels in Iranian women with breast cancer. Methods: A systematic review study was conducted in 2017. English and Persian databases (PubMed, SCOPUS, Web of Science, Google Scholar, SID, Magiran) were searched with key words such as Depression Or Depressive Disorders AND Women AND Breast Cancer OR Tumor OR Neoplasm OR Malignancy AND Iran...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29332027/phyllodes-tumors-of-the-breast-clinicopathological-analysis-of-106-cases-from-a-single-institution
#17
Boubacar Efared
BACKGROUND: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. The aim of our study was to analyse histolopathological, radiological and clinical features of PT from an experience of a single center. METHODS: It was a retrospective study including 106 patients diagnosed with phyllodes tumors on surgical specimens at the department of pathology, of Hassan II university hospital (Fez, Morocco), from 2009 to 2016...
January 10, 2018: Breast Disease
https://www.readbyqxmd.com/read/29320898/did-i-miss-it-discovering-hidden-coexisting-hematological-neoplasms-a-single-institutional-review-of-100-collision-tumors
#18
Evan Himchak, Etan Marks, Yang Shi, Yanhua Wang
A collision tumor is defined as two histologically distinct tumor types identified at the same anatomic site. Hematolymphoid proliferative disorders (HLPDs), which coincide with non-hematological neoplasms, can mimic an immune response and can easily be overlooked as an immune reaction to a solid organ neoplasm, especially when low grade. In order to avoid a delay in the diagnosis of a HLPD during the workup for a non-hematological neoplasm, we identified a cohort of 100 cases with a HLPD diagnosis during the initial workup and treatment of a non-hematological neoplasm, or vice versa...
January 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29312836/malignant-epithelial-transformation-in-phyllodes-tumor-a-population-based-case-series
#19
Ralph L Widya, Myra F Rodrigues, Pauline T Truong, Peter H Watson, Lorna M Weir, Margaret A Knowling, Elaine S Wai
Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29310379/male-breast-cancer-and-mantle-cell-lymphoma-in-a-single-patient-a-case-report-and-literature-review
#20
Jun Liu, Hongquan Wei, Keqing Zhu, Liqin Lai, Xiaoyu Han, Yue Yang
RATIONALE: Although still relatively rare, multiple primary malignant neoplasms (MPMNs) have been increasingly reported in recent years. PATIENT CONCERNS AND DIAGNOSES: A 65-year-old man was referred to our hospital for a painless, incidental left axillary lump. Ultrasound showed enlarged left axillary lymph nodes. An excisional biopsy was conducted on 3 lymph nodes. The pathological diagnosis was determined to be metastatic adenocarcinoma and mantle cell lymphoma (MCL) in the lymph nodes...
December 2017: Medicine (Baltimore)
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