keyword
MENU ▼
Read by QxMD icon Read
search

malaria transmission blocking

keyword
https://www.readbyqxmd.com/read/27912985/immunogenicity-and-malaria-transmission-reducing-potency-of-pfs48-45-and-pfs25-encoded-by-dna-vaccines-administered-by-intramuscular-electroporation
#1
Dibyadyuti Datta, Geetha P Bansal, Dietlind L Gerloff, Barry Ellefsen, Drew Hannaman, Nirbhay Kumar
Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the erythrocytic sexual stages and presentation to the immune system during infection in the human host also makes it ideal for natural boosting. However, it has been challenging to produce a fully folded, functionally active Pfs48/45, using various protein expression platforms. In this study, we demonstrate that full-length Pfs48/45 encoded by DNA plasmids is able to induce significant transmission reducing immune responses...
November 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27912876/in-vitro-and-ex-vivo-activity-of-an-azadirachta-indica-a-juss-seed-kernel-extract-on-early-sporogonic-development-of-plasmodium-in-comparison-with-azadirachtin-a-its-most-abundant-constituent
#2
Nisha Dahiya, Giuseppina Chianese, Solomon Mequanente Abay, Orazio Taglialatela-Scafati, Fulvio Esposito, Giulio Lupidi, Massimo Bramucci, Luana Quassinti, George Christophides, Annette Habluetzel, Leonardo Lucantoni
BACKGROUND: NeemAzal(®) (NA) is a quantified extract from seed kernels of neem, Azadirachta indica A.Juss. (Meliaceae), with a wide spectrum of biological properties, classically ascribed to its limonoid content. NA contains several azadirachtins (A to L), azadirachtin A (AzaA) being its main constituent. AzaA has been shown to inhibit microgamete formation of the rodent malaria parasite Plasmodium berghei, and NA was found to completely inhibit the transmission of Plasmodium berghei to Anopheles stephensi mosquitoes when administered to gametocytemic mice at a corresponding AzaA dose of 50mg/kg before exposure to mosquitoes...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27903741/whole-killed-blood-stage-vaccine-induced-immunity-suppresses-the-development-of-malaria-parasites-in-mosquitoes
#3
Feng Zhu, Taiping Liu, Chenhao Zhao, Xiao Lu, Jian Zhang, Wenyue Xu
As a malaria transmission-blocking vaccine alone does not confer a direct benefit to the recipient, it is necessary to develop a vaccine that not only blocks malaria transmission but also protects vaccinated individuals. In this study we observed that a whole-killed blood-stage vaccine (WKV) not only conferred protection against the blood-stage challenge but also markedly inhibited the transmission of different strains of the malaria parasite. Although the parasitemia is much lower in WKV-immunized mice challenged with malaria parasites, the gametocytemia is comparable between control and immunized mice during the early stages of infection...
November 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27895131/the-p-falciparum-cell-traversal-protein-for-ookinetes-and-sporozoites-as-a-candidate-for-pre-erythrocytic-and-transmission-blocking-vaccines
#4
Diego A Espinosa, Joel Vega-Rodriguez, Yevel Flores-Garcia, Amy R Noe, Christian Muñoz, Russell Coleman, Torben Bruck, Keith Haney, Alex Stevens, Diane Retallack, Jeff Allen, Thomas S Vedvick, Christopher B Fox, Steven G Reed, Randall F Howard, Ahmed M Salman, Chris J Janse, Shahid M Khan, Fidel Zavala, Gabriel M Gutierrez
Recent studies have shown that immune responses against the Cell-Traversal Protein for Plasmodium Ookinetes and Sporozoites (CelTOS) can inhibit parasite infection. While these studies provide important evidence towards the development of vaccines targeting this protein, it remains unknown whether these responses could engage the P. falciparum CelTOS in vivo. Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (PfCelTOS), we evaluated the protective effect of in vivo immune responses elicited by vaccination and assessed the neutralizing capacity of monoclonal antibodies specific against PfCelTOS...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27825738/the-gametocytocidal-efficacy-of-different-single-doses-of-primaquine-with-dihydroartemisinin-piperaquine-in-asymptomatic-parasite-carriers-in-the-gambia-a-randomized-controlled-trial
#5
Joseph Okebe, Teun Bousema, Muna Affara, Gian Luca Di Tanna, Edgard Dabira, Abdoulaye Gaye, Frank Sanya-Isijola, Henry Badji, Simon Correa, Davis Nwakanma, Jean-Pierre Van Geertruyden, Chris Drakeley, Umberto D'Alessandro
BACKGROUND: Asymptomatic low-density gametocyte carriers represent the majority of malaria-infected individuals. However, the impact of recommended treatment with single low dose of primaquine and an artemisinin-based combination therapy to reduce transmission in this group is unknown. METHODS: This was a four-arm, open label, randomized controlled trial comparing the effect of dihydroartemisinin-piperaquine (DHAP) alone or combined with single dose of primaquine (PQ) at 0...
October 23, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27815977/novel-metalloantimalarials-transmission-blocking-effects-of-water-soluble-cu-i-ag-i-and-au-i-phosphane-complexes-on-the-murine-malaria-parasite-plasmodium-berghei
#6
Sofia Tapanelli, Annette Habluetzel, Maura Pellei, Luciano Marchiò, Alessia Tombesi, Ambra Capparè, Carlo Santini
The water soluble phosphane complexes [M(L)4]PF6 (M=Cu(I), Ag(I)) and [Au(L)4]Cl (L=thp (tris(hydroxymethyl)phosphane) or PTA (1,3,5-triaza-7-phosphaadamantane)) showed notable in vitro activity against Plasmodium early sporogonic stages, the sexual forms of the malaria parasite that are responsible for infection of the mosquito vector. Effects varied according to both, the type of metal and phosphane ligands. [Ag(thp)4]PF6 was the best performing complex exhibiting a half inhibitory concentration (IC50) value in the low micromolar range (0...
October 13, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27809883/alternatives-to-currently-used-antimalarial-drugs-in-search-of-a-magic-bullet
#7
REVIEW
Akshaya Srikanth Bhagavathula, Asim Ahmed Elnour, Abdulla Shehab
Malaria is a major cause of morbidity and mortality in many African countries and parts of Asia and South America. Novel approaches to combating the disease have emerged in recent years and several drug candidates are now being tested clinically. However, it is long before these novel drugs can hit the market, especially due to a scarcity of safety and efficacy data.To reduce the malaria burden, the Medicines for Malaria Venture (MMV) was established in 1999 to develop novel medicines through industry and academic partners' collaboration...
November 4, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27789147/utilizing-direct-skin-feeding-assays-for-development-of-vaccines-that-interrupt-malaria-transmission-a-systematic-review-of-methods-and-case-study
#8
REVIEW
Elizabeth B Brickley, Mamadou Coulibaly, Erin E Gabriel, Sara A Healy, Jen C C Hume, Issaka Sagara, Sekou F Traore, Ogobara Doumbo, Patrick E Duffy
Shifting the malaria priorities from a paradigm of control and elimination to a goal of global eradication calls for renewed attention to the interruption of malaria transmission. Sustained progress toward eradication will require both improved understanding of infectious reservoirs and efficient development of novel transmission-blocking interventions, such as rapidly acting and highly efficacious therapeutics and vaccines. Here, we review the direct skin feeding assay (DSF), which has been proposed as a valuable tool for measuring the in natura transmission of malaria parasites from human hosts to mosquito vectors across heterogeneous populations...
October 24, 2016: Vaccine
https://www.readbyqxmd.com/read/27784313/an-optimised-age-based-dosing-regimen-for-single-low-dose-primaquine-for-blocking-malaria-transmission-in-cambodia
#9
Rithea Leang, Naw Htee Khu, Mavuto Mukaka, Mark Debackere, Rupam Tripura, Soy Ty Kheang, Say Chy, Neeraj Kak, Philippe Buchy, Arnaud Tarantola, Didier Menard, Arantxa Roca-Felterer, Rick M Fairhurst, Sim Kheng, Sinoun Muth, Song Ngak, Arjen M Dondorp, Nicholas J White, Walter Robert John Taylor
BACKGROUND: In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was non-pregnant patients aged ≥ 1 year (later changed to ≥ 6 months) with acute uncomplicated falciparum malaria, primarily in countries with artemisinin-resistant P...
October 27, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27780638/5-aminopyrazole-4-carboxamide-analogues-are-selective-inhibitors-of-plasmodium-falciparum-microgametocyte-exflagellation-and-potential-malaria-transmission-blocking-agents
#10
Wenlin Huang, Matthew A Hulverson, Zhongsheng Zhang, Ryan Choi, Kevin J Hart, Mark Kennedy, Rama Subba Rao Vidadala, Dustin J Maly, Wesley C Van Voorhis, Scott E Lindner, Erkang Fan, Kayode K Ojo
Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) is essential for the exflagellation of male gametocytes. Inhibition of PfCDPK4 is an effective way of blocking the transmission of malaria by mosquitoes. A series of 5-aminopyrazole-4-carboxamide analogues are demonstrated to be potent inhibitors of PfCDPK4. The compounds are also able to block exflagellation of Plasmodium falciparum male gametocytes without observable toxicity to mammalian cells.
October 10, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27749907/safety-and-immunogenicity-of-pfs25-epa-alhydrogel%C3%A2-a-transmission-blocking-vaccine-against-plasmodium-falciparum-an-open-label-study-in-malaria-na%C3%A3-ve-adults
#11
Kawsar R Talaat, Ruth D Ellis, Janet Hurd, Autumn Hentrich, Erin Gabriel, Noreen A Hynes, Kelly M Rausch, Daming Zhu, Olga Muratova, Raul Herrera, Charles Anderson, David Jones, Joan Aebig, Sarah Brockley, Nicholas J MacDonald, Xiaowei Wang, Michael P Fay, Sara A Healy, Anna P Durbin, David L Narum, Yimin Wu, Patrick E Duffy
Transmission-blocking vaccines (TBVs) that target sexual stage parasite development could be an integral part of measures for malaria elimination. Pfs25 is a leading TBV candidate, and previous studies conducted in animals demonstrated an improvement of its functional immunogenicity after conjugation to EPA, a recombinant, detoxified ExoProtein A from Pseudomonas aeruginosa. In this report, we describe results of an open-label, dose-escalating Phase 1 trial to assess the safety and immunogenicity of Pfs25-EPA conjugates formulated with Alhydrogel®...
2016: PloS One
https://www.readbyqxmd.com/read/27748294/strategies-recent-development-of-transmission-blocking-vaccines-against-plasmodium-falciparum
#12
Neha Chaturvedi, Praveen K Bharti, Archana Tiwari, Neeru Singh
Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. These antigens are immunogenic with limited genetic diversity. Pfs25 is a leading candidate and currently in phase I clinical trial. Efforts are now focused on the cost-effective production of potent antigens using safe adjuvants and optimization of vaccine delivery system that are capable of inducing strong immune responses...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27701420/characterization-of-novel-antimalarial-compound-act-451840-preclinical-assessment-of-activity-and-dose-efficacy-modeling
#13
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgent need for the development of new antimalarials, a chemical class of potent antimalarial compounds with a novel mode of action was recently identified. Herein, the preclinical characterization of one of these compounds, ACT-451840, conducted in partnership with academic and industrial groups is presented...
October 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27649682/natural-products-from-zanthoxylum-heitzii-with-potent-activity-against-the-malaria-parasite
#14
Christopher Dean Goodman, Ingvild Austarheim, Vanessa Mollard, Bertin Mikolo, Karl Egil Malterud, Geoffrey I McFadden, Helle Wangensteen
BACKGROUND: Zanthoxylum heitzii (Rutaceae) (olon) is used in traditional medicine in Central and West Africa to treat malaria. To identify novel compounds with anti-parasitic activity and validate medicinal usage, extracts and compounds isolated from this tree were tested against the erythrocytic stages of the human malaria parasite Plasmodium falciparum and for inhibition of transmission in rodent malaria parasite Plasmodium berghei. RESULTS: Hexane bark extract showed activity against P...
September 20, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27644319/genetic-characterization-of-plasmodium-putative-pantothenate-kinase-genes-reveals-their-essential-role-in-malaria-parasite-transmission-to-the-mosquito
#15
Robert J Hart, Emmanuel Cornillot, Amanah Abraham, Emily Molina, Catherine S Nation, Choukri Ben Mamoun, Ahmed S I Aly
The metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitamin B5) has long been considered as an excellent target for the development of selective antimicrobials. Earlier studies in the human malaria parasite Plasmodium falciparum have shown that pantothenate analogs interfere with pantothenate phosphorylation and block asexual blood stage development. Although two eukaryotic-type putative pantothenate kinase genes (PanK1 and PanK2) have been identified in all malaria parasite species, their role in the development of Plasmodium life cycle stages remains unknown...
September 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27642038/transmission-blocking-effects-of-neem-azadirachta-indica-seed-kernel-limonoids-on-plasmodium-berghei-early-sporogonic-development
#16
Sofia Tapanelli, Giuseppina Chianese, Leonardo Lucantoni, Rakiswendé Serge Yerbanga, Annette Habluetzel, Orazio Taglialatela-Scafati
Azadirachta indica, known as neem tree and traditionally called "nature's drug store" makes part of several African pharmacopeias and is widely used for the preparation of homemade remedies and commercial preparations against various illnesses, including malaria. Employing a bio-guided fractionation approach, molecules obtained from A. indica ripe and green fruit kernels were tested for activity against early sporogonic stages of Plasmodium berghei, the parasite stages that develop in the mosquito mid gut after an infective blood meal...
October 2016: Fitoterapia
https://www.readbyqxmd.com/read/27612458/an-inter-laboratory-comparison-of-standard-membrane-feeding-assays-for-evaluation-of-malaria-transmission-blocking-vaccines
#17
Kazutoyo Miura, Will J R Stone, Karin M Koolen, Bingbing Deng, Luwen Zhou, Geert-Jan van Gemert, Emily Locke, Merribeth Morin, Teun Bousema, Robert W Sauerwein, Carole A Long, Koen J Dechering
BACKGROUND: An effective malaria transmission-blocking vaccine may play an important role in malaria elimination efforts, and a robust biological assay is essential for its development. The standard membrane-feeding assay (SMFA) for Plasmodium falciparum infection of mosquitoes is considered a "gold standard" assay to measure transmission-blocking activity of test antibodies, and has been utilized widely in both non-clinical and clinical studies. While several studies have discussed the inherent variability of SMFA within a study group, there has been no assessment of inter-laboratory variation...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27598328/inhibition-of-malaria-infection-in-transgenic-anopheline-mosquitoes-lacking-salivary-gland-cells
#18
Daisuke S Yamamoto, Megumi Sumitani, Katsumi Kasashima, Hideki Sezutsu, Hiroyuki Matsuoka
Malaria is an important global public health challenge, and is transmitted by anopheline mosquitoes during blood feeding. Mosquito vector control is one of the most effective methods to control malaria, and population replacement with genetically engineered mosquitoes to block its transmission is expected to become a new vector control strategy. The salivary glands are an effective target tissue for the expression of molecules that kill or inactivate malaria parasites. Moreover, salivary gland cells express a large number of molecules that facilitate blood feeding and parasite transmission to hosts...
September 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27567642/reviewing-south-africa-s-malaria-elimination-strategy-2012-2018-progress-challenges-and-priorities
#19
Jaishree Raman, Natashia Morris, John Frean, Basil Brooke, Lucille Blumberg, Philip Kruger, Aaron Mabusa, Eric Raswiswi, Bridget Shandukani, Eunice Misani, Mary-Anne Groepe, Devanand Moonasar
BACKGROUND: With a sustained national malaria incidence of fewer than one case per 1000 population at risk, in 2012 South Africa officially transitioned from controlling malaria to the ambitious goal of eliminating malaria within its borders by 2018. This review assesses the progress made in the 3 years since programme re-orientation while highlighting challenges and suggesting priorities for moving the malaria programme towards elimination. METHODS: National malaria case data and annual spray coverage data from 2010 until 2014 were assessed for trends...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27566334/impact-of-exposure-to-mosquito-transmission-blocking-antibodies-on-plasmodium-falciparum-population-genetic-structure
#20
Maurice M Sandeu, Luc Abate, Majoline T Tchioffo, Albert N Bayibéki, Parfait H Awono-Ambéné, Sandrine E Nsango, Cédric B Chesnais, Rhoel R Dinglasan, Thierry de Meeûs, Isabelle Morlais
Progress in malaria control has led to a significant reduction of the malaria burden. Interventions that interrupt transmission are now needed to achieve the elimination goal. Transmission-blocking vaccines (TBV) that aim to prevent mosquito infections represent promising tools and several vaccine candidates targeting different stages of the parasite's lifecycle are currently under development. A mosquito-midgut antigen, the anopheline alanyl aminopeptidase (AnAPN1) is one of the lead TBV candidates; antibodies against AnAPN1 prevent ookinete invasion...
August 23, 2016: Infection, Genetics and Evolution
keyword
keyword
65688
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"