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Fibrin glue

Jin-Young Jang, Yong Chan Shin, Youngmin Han, Joon Seong Park, Ho-Seong Han, Ho Kyoung Hwang, Dong Sup Yoon, Jae Keun Kim, Yoo Seok Yoon, Dae Wook Hwang, Chang Moo Kang, Woo Jung Lee, Jin Seok Heo, Mee Joo Kang, Ye Rim Chang, Jihoon Chang, Woohyun Jung, Sun-Whe Kim
Importance: The rate of postoperative pancreatic fistula (POPF) after distal pancreatectomy ranges from 13% to 64%. To prevent POPF, polyglycolic acid (PGA) mesh was introduced, but its effect has been evaluated only in small numbers of patients and retrospective studies. Objective: To evaluate the efficacy of PGA mesh in preventing POPF after distal pancreatectomy. Design, Setting, and Participants: Prospective randomized clinical, single-blind (participant), parallel-group trial at 5 centers between November 2011 and April 2014...
October 26, 2016: JAMA Surgery
A Gabriella Wernicke, Stefanie P Lazow, Shoshana Taube, Menachem Z Yondorf, Ilhami Kovanlikaya, Dattatreyudu Nori, Paul Christos, John A Boockvar, Susan Pannullo, Philip E Stieg, Theodore H Schwartz
BACKGROUND: Cesium-131 (Cs-131) brachytherapy is used to reduce local recurrence of resected brain metastases. In order to ensure dose homogeneity and reduce risk of radiation necrosis, inter-seed distance and cavity volume must remain stable during delivery. OBJECTIVE: To investigate the efficacy of the "seeds-on-a-string" technique with intracavitary fibrin glue in achieving cavity volume stability. METHODS: We placed intra-operative Cs-131 brachytherapy in 30 cavities post-resection of brain metastases...
March 2016: Oper Neurosurg (Hagerstown)
Li-Jie, Hong-Biao Li, Xi-Cheng Zhao, Qin-Lei, Xin-Qiang Jiang, Zhen-Hua Zhang
OBJECTIVE: To evaluate the efficacy and safety of fibrin sealant for the reduction of postoperative blood loss and transfusion requirements in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). METHODS: Electronic databases including PubMed, Embase, CENTRAL (Cochrane Controlled Trials Register), Web of Science and Google Scholar were searched from database inception to February 2016. All randomized controlled trials evaluating the efficacy and safety of topical administration of fibrin glue during primary THA or TKA were included in our meta-analysis...
October 20, 2016: International Journal of Surgery
Jinshan Guo, Gloria B Kim, Dingying Shan, Jimin P Kim, Jianqing Hu, Wei Wang, Fawzi G Hamad, Guoying Qian, Elias B Rizk, Jian Yang
For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge in developing such adhesives was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent...
October 12, 2016: Biomaterials
Anand Kaul, Sunil Manjila, Jonathan P Miller
: Isadore Max Tarlov (1905-1977) is primarily remembered for his 1938 description of the eponymous perineural "Tarlov cyst." However, during his long career as a neurosurgeon and researcher, he was responsible for many other observations and inventions that influenced the development of neurosurgery in the 20th century. While studying at Johns Hopkins Medical School he was acquainted with Walter Dandy, and he became the first resident to study under Wilder Penfield at the newly formed Montreal Neurological Institute...
November 2016: Neurosurgery
Luca Ferretto, Sandro Irsara
PURPOSE: To describe a sac embolization technique modification for type II endoleak prevention that makes a totally percutaneous approach feasible during endovascular aneurysm repair (EVAR) using the Excluder stent-graft. TECHNIQUE: Percutaneous access of the common femoral arteries is obtained and 2 suture-mediated closure systems are placed on each side. A 16-F or 18-F sheath is placed for delivery of the Excluder stent-graft main body and a 16-F sheath is used on the contralateral side...
October 12, 2016: Journal of Endovascular Therapy
Gürhan Güngör, Gökhan Demiral, Metin Şenol, Barış Bayraktar, Yahya Çelik, Salih Bölük
INTRODUCTION: Major complications of colonic anastomosis include fistula, bleeding, and anastomotic stricture, and the most common one is anastomotic leakage. Many organic or inorganic tissue adhesives are being used such as fibrin glue or cyanoacrylate to strengthen or protect colonic anastomosis. Up to now, a great number of studies have been carried out to investigate the effects of these biomaterials. AIM: To determine the effect of cyanoacrylate application on anastomosis safety...
2016: Przegla̜d Gastroenterologiczny
David Wasylynko
OBJECTIVE: To present a case of chronic elbow pain as a result of a hidden underlying osteochondral defect. CLINICAL FEATURES: A 17-year old baseball player presented with chronic lateral elbow pain. Examination revealed swelling of the elbow with signs of possible ligament, muscle, and tendon injury. DIAGNOSIS AND TREATMENT: Although there was apparent soft-tissue injury, the elbow swelling created immediate suspicion of a more serious underlying condition...
September 2016: Journal of the Canadian Chiropractic Association
M Buechter, J M Theysohn, A Kahraman, P Manka, G Gerken, A Canbay, A Dechêne
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is considered the gold standard for treatment of gastrointestinal variceal bleeding refractory to endoscopic therapy in patients with portal hypertension. Clinically relevant hemorrhage from rectal varices is less frequent than from other sources, and the therapeutic role of TIPS is still ambiguous. Case report: A 57-year-old female patient was referred to us in December 2015 with severe signs of decompensated alcohol-induced liver cirrhosis. During hospitalization, she presented with recurrent hematochezia from rectal varices following electrosurgical snare removal of a rectal adenoma...
October 5, 2016: Zeitschrift Für Gastroenterologie
Jussi Sarin, Markus Hiltunen, Leena Hupa, Jaakko Pulkkinen, Pekka K Vallittu
Bioactive glass (BG)-containing fiber-reinforced composite implants, typically screw-retained, have started to be used clinically. In this study, we tested the mechanical strength of composites formed by a potential implant adhesive of n-butyl-2-cyanoacrylate glue and BG S53P4 particles. Water immersion for 3, 10 or 30 days had no adverse effect on the compression strength. When cyanoacrylate glue-BG-composites were subjected to simulated body fluid immersion, the average pH rose to 7.52 (SD 0.066) from the original value of 7...
September 28, 2016: Bio-medical Materials and Engineering
Ilan Igor Maizlin, Jerry S Chen, Nicholas James Smith, David A Rogers
Posttraumatic esophagomediastinal fistula is an uncommon clinical entity that warrants surgical awareness due to its life-threatening potential. Its management, especially in previously operated field, is controversial and several endoscopic methods are being proposed as alternatives. Ours is the first report of endoscopic fulguration and fibrin injection in successful closure of such fistula. A 9-year-old female sustained complete tracheoesophageal transection from a gunshot wound to the neck and underwent immediate primary repair...
September 2016: American Surgeon
Yudai Fukui, Junichi Shindoh, Shuichiro Matoba, Kenji Tomizawa, Yutaka Hanaoka, Shigeo Toda, Jin Moriyama, Hiroya Kuroyanagi
A 53-year-old man was readmitted with abdominal distention 2 weeks after undergoing laparoscopic low anterior resection with para-aortic lymphadenectomy for advanced rectal cancer (T4aN1M0, Stage IIIb). Ultrasound revealed massive ascites, and paracentesis revealed chylous fluid with a markedly elevated triglyceride level (1762 mg/dL). Despite conservative management, the fistula remained on postoperative day 120. On percutaneous lymphangiography, the chylous leakage point was clearly visualized at the para-aortic site, and surgical intervention was planned...
September 26, 2016: Asian Journal of Endoscopic Surgery
Yasuaki Nagami, Masatsugu Shiba, Kazunari Tominaga, Masaki Ominami, Shusei Fukunaga, Satoshi Sugimori, Fumio Tanaka, Noriko Kamata, Tetsuya Tanigawa, Hirokazu Yamagami, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
BACKGROUND AND STUDY AIM: The incidence of stricture formation caused by endoscopic submucosal dissection (ESD) for widespread lesions is high, and stricture formation can reduce quality of life. We evaluated the prophylactic efficacy of hybrid therapy using a locoregional steroid injection and polyglycolic acid (PGA) sheets with fibrin glue to prevent stricture formation after esophageal ESD in high risk patients in whom we predicted stricture formation would be difficult to prevent with a single prophylactic steroid injection...
September 2016: Endoscopy International Open
Houfa Yin, Peijin Qiu, Fang Wu, Wei Zhang, Wenqi Teng, Zhenwei Qin, Chao Li, Jiaojie Zhou, Zhi Fang, Qiaomei Tang, Qiuli Fu, Jian Ma, Yabo Yang
The scarcity of corneal tissue to treat deep corneal defects and corneal perforations remains a challenge. Currently, small incision lenticule extraction (SMILE)-derived lenticules appear to be a promising alternative for the treatment of these conditions. However, the thickness and toughness of a single piece of lenticule are limited. To overcome these limitations, we constructed a corneal stromal equivalent with SMILE-derived lenticules and fibrin glue. In vitro cell culture revealed that the corneal stromal equivalent could provide a suitable scaffold for the survival and proliferation of corneal epithelial cells, which formed a continuous pluristratified epithelium with the expression of characteristic markers...
2016: Scientific Reports
Clotilde Fuentes-Orozco, Salvador González-Mercado, Joel Mario Sandoval-Sandoval, Carlos Valdespino-Mejía, Eduardo González-González, Juan Narciso Ramírez-Robles, Benjamín Gómez-Navarro, Blanca Estela Dávalos-Delgadillo, Leticia Marquez-Leaño, Anais Ramírez-Arce, Elizabeth Andalón-Dueñas, Arturo Espinosa-Partida, Michel Dassaejv Macías-Amezcua, Alejandro González-Ojeda
BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinical trial involving 78 recipients randomly assigned to receive fibrin glue and 79 in the control group without the application of fibrin glue. Patients were followed for six months after surgery...
September 20, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Mateus Vidigal de Castro, Roberta Barbizan, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues de Oliveira
Axonal injuries at the interface between central and peripheral nervous system, such as ventral root avulsion (VRA), induce important degenerative processes, mostly resulting in neuronal and motor function loss. In the present work, we have compared two different fibrin sealants, one derived from human blood and another derived from animal blood and Crotalus durissus terrificus venom, as a promising treatment for this type of injury. Lewis rats were submitted to VRA (L4-L6) and had the avulsed roots reimplanted to the surface of the spinal cord, with the aid of fibrin sealant...
2016: Neural Plasticity
Hideaki Suzuki, Hiroki Koizumi, Takuro Kitamura, Takahisa Tabata, Yasuhiro Kise, Koichi Hashida
Myringoplasty is one of the basic procedures in otologic surgery, and is important to achieve good hearing outcome. The temporal fascia is most widely used and considered to be a stable graft in this procedure, although 10-20% of patients develop reperforation after surgery, which is often hard to repair, even by revision surgery. We herein conducted revision myringoplasty using a cartilage graft to repair postoperative reperforation in 7 patients (8 ears) with chronic otitis media. The patients were 3 males and 4 females, aged 13-80 years with an average of 53...
September 2016: Journal of UOEH
Önder Sürgit, Nadir Turgut Çavuşoğlu, Murat Özgür Kılıç, Yılmaz Ünal, Pınar Nergis Koşar, Duygu İçen
PURPOSE: Seroma is among the most common complications of laparoscopic total extraperitoneal (TEP) for especially large indirect inguinal hernia, and may be regarded as a recurrence by some patients. A potential area localized behind the mesh and extending from the inguinal cord into the scrotum may be one of the major etiological factors of this complication. Our aim is to describe a novel technique in preventing pseudorecurrence by using fibrin sealant to close that potential dead space...
September 2016: Annals of Surgical Treatment and Research
Andrea Fabio Manunta, Pietro Zedde, Susanna Pilicchi, Stefano Rocca, Roy R Pool, Maria Dattena, Gerolamo Masala, Laura Mara, Sara Casu, Daniela Sanna, Maria Lucia Manunta, Eraldo Sanna Passino
PURPOSE: the aim of this study was to determine whether local delivery of embryonic stem-like (ESL) cells into osteochondral defects in the femoral condyles of sheep would enhance regeneration of hyaline articular cartilage. METHODS: male ESL cells embedded in fibrin glue were engrafted into osteochondral defects in the medial condyles (ESL-M) of the left femur in 22 ewes. An identical defect was created in the medial condyle of the contralateral stifle joint and left untreated as a control (empty defect, ED)...
April 2016: Joints
Fuminari Komatsu, Masaaki Imai, Akihiro Hirayama, Kazuko Hotta, Naokazu Hayashi, Shinri Oda, Masami Shimoda, Mitsunori Matsumae
Background Endoscopic microvascular decompression (MVD) offers reliable identification of neurovascular conflicts under superb illumination, and it provides minimally invasive surgery for trigeminal neuralgia and hemifacial spasm. Transposition techniques have been reported as a decompression method to prevent adhesion and granuloma formation around decompression sites, providing better surgical outcomes. The feasibility and effects of transposition under endoscopic MVD were evaluated. Material and Methods Fully endoscopic MVD was performed using 4-mm 0- and 30-degree endoscopes...
September 5, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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