keyword
https://read.qxmd.com/read/38533656/variable-effects-of-exposure-to-ionic-silver-in-wound-associated-bacterial-pathogens
#21
JOURNAL ARTICLE
Reem Binsuwaidan, Osama Almuzaini, Steven Mercer, Christopher Doherty, Jawahir Mokhtar, Andrew J McBain, Ruth Ledder, Gavin J Humphreys
Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic concentrations of antimicrobial over prolonged periods of time. In this study, a panel of chronic wound bacteria, Pseudomonas aeruginosa (two strains), Staphylococcus aureus and Escherichia coli, were exposed to silver nitrate on agar. Phenotypic characterisation was achieved using broth microdilution sensitivity testing, a crystal violet biofilm assay and a wax moth pathogenesis model...
March 26, 2024: Letters in Applied Microbiology
https://read.qxmd.com/read/38533273/enteric-bacterial-infections-antimicrobial-susceptibility-pattern-intestinal-parasites-and-associated-factors-among-food-handlers-in-yabelo-town-borena-zone-southern-ethiopia
#22
JOURNAL ARTICLE
Tibeso Gemechu, Alqeer Aliyo
BACKGROUND: Foodborne illnesses are the main cause of morbidity and mortality in the twenty-first century, and food handlers are the main source of these illnesses. OBJECTIVE: The study aimed to assess the prevalence of intestinal parasites, enteric bacteria, antimicrobial susceptibility patterns, and associated factors among food handlers working in a food and drinking establishment in Yabelo town, Borena zone, Southern Ethiopia, in 2022. METHODS: A facility-based cross-sectional study design was employed to assess the food handler's state of health...
2024: Microbiology Insights
https://read.qxmd.com/read/38532963/diarrhea-case-surveillance-in-the-enterics-for-global-health-shigella-surveillance-study-epidemiologic-methods
#23
JOURNAL ARTICLE
Hannah E Atlas, Bakary Conteh, Md Taufiqul Islam, Khuzwayo C Jere, Richard Omore, Doh Sanogo, Francesca Schiaffino, Mohammad Tahir Yousafzai, Naveed Ahmed, Alex O Awuor, Henry Badji, Jennifer Cornick, Erika Feutz, Sean R Galagan, Fadima C Haidara, Bri'Anna Horne, Md Ismail Hossen, Aneeta Hotwani, Eric R Houpt, Abdoulie F Jallow, Mehrab Karim, Adama Mamby Keita, Youssouf Keita, Farhana Khanam, Jie Liu, Thandizo Malemia, Alhagie Manneh, Christine J McGrath, Dilruba Nasrin, Maureen Ndalama, John Benjamin Ochieng, Billy Ogwel, Maribel Paredes Olortegui, Loyda Fiorella Zegarra Paredes, Tackeshy Pinedo Vasquez, James A Platts-Mills, Syed Qudrat-E-Khuda, Sonia Qureshi, Md Nazmul Hasan Rajib, Elizabeth T Rogawski McQuade, Shazia Sultana, Sharon M Tennant, Kirkby D Tickell, Desiree Witte, Pablo Peñataro Yori, Nigel A Cunliffe, M Jahangir Hossain, Margaret N Kosek, Karen L Kotloff, Firdausi Qadri, Farah Naz Qamar, Milagritos D Tapia, Patricia B Pavlinac
BACKGROUND: Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, a precursor to stunting and lifelong morbidity. Several promising Shigella vaccines are in development and field efficacy trials will require a consortium of potential vaccine trial sites with up-to-date Shigella diarrhea incidence data. METHODS: The Enterics for Global Health (EFGH) Shigella surveillance study will employ facility-based enrollment of diarrhea cases aged 6-35 months with 3 months of follow-up to establish incidence rates and document clinical, anthropometric, and financial consequences of Shigella diarrhea at 7 country sites (Mali, Kenya, The Gambia, Malawi, Bangladesh, Pakistan, and Peru)...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532960/-shigella-detection-and-molecular-serotyping-with-a-customized-taqman-array-card-in-the-enterics-for-global-health-efgh-shigella-surveillance-study
#24
JOURNAL ARTICLE
Jie Liu, Paul F Garcia Bardales, Kamrul Islam, Sheikh Jarju, Jane Juma, Chimwemwe Mhango, Queen Naumanga, Sonia Qureshi, Catherine Sonye, Naveed Ahmed, Fatima Aziz, Md Taufiqur Rahman Bhuiyan, Mary Charles, Nigel A Cunliffe, Mahamadou Abdou, Sean R Galagan, Ensa Gitteh, Ibrehima Guindo, M Jahangir Hossain, Abdoulie M J Jabang, Khuzwayo C Jere, Flywell Kawonga, Mariama Keita, Noumou Yakhouba Keita, Karen L Kotloff, Wagner V Shapiama Lopez, Stephen Munga, Maribel Paredes Olortegui, Richard Omore, Patricia B Pavlinac, Firdausi Qadri, Farah Naz Qamar, S M Azadul Alam Raz, Laura Riziki, Francesca Schiaffino, Suzanne Stroup, Sarata Nassoun Traore, Tackeshy Pinedo Vasquez, Mohammad Tahir Yousafzai, Martin Antonio, Jennifer E Cornick, Furqan Kabir, Farhana Khanam, Margaret N Kosek, John Benjamin Ochieng, James A Platts-Mills, Sharon M Tennant, Eric R Houpt
BACKGROUND: Quantitative polymerase chain reaction (qPCR) targeting ipaH has been proven to be highly efficient in detecting Shigella in clinical samples compared to culture-based methods, which underestimate Shigella burden by 2- to 3-fold. qPCR assays have also been developed for Shigella speciation and serotyping, which is critical for both vaccine development and evaluation. METHODS: The Enterics for Global Health (EFGH) Shigella surveillance study will utilize a customized real-time PCR-based TaqMan Array Card (TAC) interrogating 82 targets, for the detection and differentiation of Shigella spp, Shigella sonnei , Shigella flexneri serotypes, other diarrhea-associated enteropathogens, and antimicrobial resistance (AMR) genes...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532184/repurposing-fusidic-acid-as-an-antimicrobial-against-enterococci-with-a-low-probability-of-resistance-development
#25
JOURNAL ARTICLE
Mark M Abdelmassih, Maha M Ismail, Mona T Kashef, Tamer Essam
Drug repurposing constitutes a strategy to combat antimicrobial resistance, by using agents with known safety, pharmacokinetics, and pharmacodynamics. Previous studies have implemented new fusidic acid (FA) front-loading-dose regimens, allowing higher serum levels than those achievable with ordinary doses. As susceptibility breakpoints are affected by serum level, we evaluated the repurposing of FA as an antimicrobial product against enterococci. FA minimum inhibitory concentrations (MICs) against standard enterococci strains; Enterococcus faecalis ATCC 29212 and Enterococcus faecium ATCC 27270 were 2 and 4 µg/mL, respectively...
March 27, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38531847/antimicrobial-resistance-burden-pre-and-post-covid-19-pandemic-with-mapping-the-multidrug-resistance-in-egypt-a-comparative-cross-sectional-study
#26
JOURNAL ARTICLE
Shaimaa Abdelaziz Abdelmoneim, Ramy Mohamed Ghazy, Eman Anwar Sultan, Mahmoud A Hassaan, Mohamed Anwar Mahgoub
Overuse of antibiotics during coronavirus disease 2019 (COVID-19) in an attempt to reduce COVID-19 mortality in the short term may have contributed to long-term mortality from antimicrobial resistance (AMR). The aim of this study was to evaluate the impact of the COVID-19 pandemic on AMR in Egypt and map the distribution of multidrug-resistant (MDR) and extensive drug-resistant (XDR) across Egypt. Through a multicenter cross-sectional study 2430 culture results were collected in 2019 and 2022 pre and post-COVID-19 pandemic in Egypt, including 400 Klebsiella pneumoniae, 760 Escherichia coli, 650 Acinetobacter baumannii, and 620 Methicillin-resistant staphylococcus aureus (MRSA) culture results...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531408/multipad-agarose-plate-a-rapid-and-high-throughput-approach-for-antibiotic-susceptibility-testing
#27
JOURNAL ARTICLE
Morten Kals, Leonardo Mancini, Jurij Kotar, Allen Donald, Pietro Cicuta
We describe a phenotypic antibiotic susceptibility testing (AST) method that can provide an eightfold speed-up in turnaround time compared with the current clinical standard by leveraging advances in microscopy and single-cell imaging. A newly developed growth plate containing 96 agarose pads, termed the multipad agarose plate (MAP), can be assembled at low cost. Pads can be prepared with dilution series of antibiotics. Bacteria are seeded on the pads and automatically imaged using brightfield microscopy, with a fully automated segmentation pipeline quantifying microcolony formation and growth rate...
March 2024: Journal of the Royal Society, Interface
https://read.qxmd.com/read/38530917/clonal-expansion-of-a-streptococcus-pneumoniae-serotype-3-capsule-variant-sequence-type-700-with-enhanced-vaccine-escape-potential-after-13-valent-pneumococcal-conjugate-vaccine-introduction
#28
JOURNAL ARTICLE
Akuzike Kalizang'oma, Todd D Swarthout, Thandie S Mwalukomo, Arox Kamng'ona, Comfort Brown, Jacquline Msefula, Hayley Demetriou, Jia Mun Chan, Lucy Roalfe, Uri Obolski, Jose Lourenço, David Goldblatt, Chrispin Chaguza, Neil French, Robert S Heyderman
BACKGROUND: Streptococcus pneumoniae serotype 3 remains a problem globally. Malawi introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2011, but there has been no direct protection against serotype 3 carriage. We explored whether vaccine escape by serotype 3 is due to clonal expansion of a lineage with a competitive advantage. METHODS: The distribution of serotype 3 Global Pneumococcal Sequence Clusters (GPSCs) and sequence types (STs) globally was assessed using sequences from the Global Pneumococcal Sequencing Project...
March 26, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38530058/characterization-of-clumpy-adhesion-of-escherichia-coli-to-human-cells-and-associated-factors-influencing-antibiotic-sensitivity
#29
JOURNAL ARTICLE
Muhammad Moman Khan, Katarzyna Sidorczuk, Juliane Becker, Adrianna Aleksandrowicz, Karolina Baraniewicz, Christina Ludwig, Aamir Ali, Robert A Kingsley, Peter Schierack, Rafał Kolenda
UNLABELLED: Escherichia coli intestinal infection pathotypes are characterized by distinct adhesion patterns, including the recently described clumpy adhesion phenotype. Here, we identify and characterize the genetic factors contributing to the clumpy adhesion of E. coli strain 4972. In this strain, the transcriptome and proteome of adhered bacteria were found to be distinct from planktonic bacteria in the supernatant. A total of 622 genes in the transcriptome were differentially expressed in bacteria present in clumps relative to the planktonic bacteria...
March 26, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38530016/evaluation-of-vector-susceptibility-in-aedes-aegypti-and-culex-pipiens-pallens-to-tibet-orbivirus
#30
JOURNAL ARTICLE
Nanjie Ren, Qianqian Jin, Fei Wang, Doudou Huang, Cihan Yang, Wahid Zaman, Ferdinand Villanueva Salazar, Qiyong Liu, Zhiming Yuan, Han Xia
Mosquito-borne viruses cause various infectious diseases in humans and animals. Tibet orbivirus (TIBOV), a newly identified arbovirus, efficiently replicates in different types of vertebrate and mosquito cells, with its neutralizing antibodies detected in cattle and goats. However, despite being isolated from Culicoides midges , Anopheles, and Culex mosquitoes, there has been a notable absence of systematic studies on its vector competence. Thus, in this study, Aedes aegypti and Culex pipiens pallens were reared in the laboratory to measure vector susceptibility through blood-feeding infection...
March 26, 2024: MSphere
https://read.qxmd.com/read/38529473/spectrum-and-antibiotic-sensitivity-of-bacterial-keratitis-a-retrospective-analysis-of-eight-years-in-a-tertiary-referral-hospital-in-southwest-china
#31
JOURNAL ARTICLE
Rui-Qin Guo, Ji Yang, Ya-Bin Yang, Ya-Nan Chen, Yu-Yuan Xiao, Ping Xiang, Meng-Jie Dong, Min-Fang He, Yin-Ting Wang, Yun-Ling Xiao, Hong-Qin Ke, Hai Liu
PURPOSE: The objective of this study was to investigate the epidemiological characteristics, distribution of isolates, prevailing patterns, and antibiotic susceptibility of bacterial keratitis (BK) in a Tertiary Referral Hospital located in Southwest China. METHODS: A retrospective analysis was conducted on 660 cases of bacterial keratitis occurring between January 2015 and December 2022. The demographic data, predisposing factors, microbial findings, and antibiotic sensitivity profiles were examined...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38529437/the-prevalence-and-antimicrobial-susceptibility-of-methicillin-resistant-staphylococcus-aureus-before-and-after-the-covid-19-pandemic-in-a-tertiary-saudi-hospital
#32
JOURNAL ARTICLE
Omar B Ahmed, Fayez S Bahwerth, Radi Alsafi, Eman A Elsebaei, Gamal T Ebid, Abdulrhaman Theyab, Hamza Assaggaf
BACKGROUND: Methicillin-resistant Staphylococcus  aureus (MRSA) has become a major public health problem all over the world. After the 2019 coronavirus illness (COVID-19), the pandemic may have influenced research priorities and resource allocation, potentially affecting the ability to monitor MRSA trends. AIMS: The study aimed to evaluate the prevalence of S. aureus, including MRSA infections, and their antimicrobial susceptibilities over the years 2019 and 2020 in a tertiary hospital in Makkah City, KSA...
February 2024: Curēus
https://read.qxmd.com/read/38528873/accessing-the-behavior-and-awareness-of-veterinary-professionals-towards-antimicrobials-use-and-antimicrobial-resistance-in-indian-district
#33
JOURNAL ARTICLE
Virendra S Dhayal, Bilal Ur Rehman, Ayana Krishnan, Vijay Pal Singh
INTRODUCTION: Antimicrobial resistance (AMR) poses a significant public health threat, and understanding the awareness and practices of healthcare professionals is crucial for its mitigation. Since the animal sector plays a key role in India's economy, we decided to explore the understanding of Antimicrobial Use (AMU) and AMR among veterinary professionals. METHODS: The study aimed to evaluate the awareness and behavior of veterinarians and para-veterinarians working in the Jhunjhunu district, Rajasthan, India, concerning AMU and AMR...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38527711/structural-and-kinetic-analysis-of-the-monofunctional-staphylococcus-aureus-pbp1
#34
JOURNAL ARTICLE
Christopher G Bon, Jason C Grigg, Jaeyong Lee, Craig S Robb, Nathanael A Caveney, Lindsay D Eltis, Natalie C J Strynadka
Staphylococcus aureus, an ESKAPE pathogen, is a major clinical concern due to its pathogenicity and manifold antimicrobial resistance mechanisms. The commonly used β-lactam antibiotics target bacterial penicillin-binding proteins (PBPs) and inhibit crosslinking of peptidoglycan strands that comprise the bacterial cell wall mesh, initiating a cascade of effects leading to bacterial cell death. S. aureus PBP1 is involved in synthesis of the bacterial cell wall during division and its presence is essential for survival of both antibiotic susceptible and resistant S...
March 23, 2024: Journal of Structural Biology
https://read.qxmd.com/read/38527226/antimicrobial-lasso-peptide-cloacaenodin-utilizes-a-unique-tonb-dependent-transporter-to-access-susceptible-bacteria
#35
JOURNAL ARTICLE
Drew V Carson, Reecan J Juarez, Truc Do, Zhongyue J Yang, A James Link
The development of new antimicrobial agents effective against Gram-negative bacteria remains a major challenge in drug discovery. The lasso peptide cloacaenodin has potent antimicrobial activity against multiple strains in the Enterobacter genus, one of the ESKAPE pathogens. Here, we show that cloacaenodin uses a previously uncharacterized TonB-dependent transporter, which we name CloU, to cross the outer membrane (OM) of susceptible bacteria. Inner membrane transport is mediated by the protein SbmA. CloU is distinct from the known OM transporters (FhuA and PupB) utilized by other antimicrobial lasso peptides and thus offers important insight into the spectrum of activity of cloacaenodin...
March 25, 2024: ACS Chemical Biology
https://read.qxmd.com/read/38526879/synergistic-effects-of-ceftazidime-avibactam-combined-with-meropenem-in-a-murine-model-of-infection-with-kpc-producing-klebsiella-pneumoniae
#36
JOURNAL ARTICLE
Mei Zheng, Fu-Hao Li, Juan Liu, Wen-Jie Li, Ruo-Xi Yin, Da-Tong Cai, Diego O Andrey, Si-Lin Zheng, Ana C Gales, Wan-Jiang Zhang, Jian Sun, Xiao-Ping Liao, Yang Yu
OBJECTIVES: The emergence and expansion of carbapenem-resistant Klebsiella pneumoniae infections is a concern due to the lack of 'first-line' antibiotic treatment options. The ceftazidime/avibactam is an important clinical treatment for carbapenem-resistant K. pneumoniae infections but there is an increasing number of cases of treatment failure and drug resistance. Therefore, a potential solution is combination therapies that result in synergistic activity against K. pneumoniae carbapenemase: producing K...
March 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38526086/when-the-trojan-horse-is-unable-to-reach-inside-the-city-investigation-of-the-mechanism-of-resistance-behind-the-first-reported-cefiderocol-resistant-e-coli-in-canada
#37
JOURNAL ARTICLE
Kevin R Barker, Gabriel W Rebick, Ken Fakharuddin, Clayton MacDonald, Michael R Mulvey, Laura F Mataseje
Gram-negative metallo-β-lactamase-producing bacteria can be extremely problematic, especially when found to be extensively drug-resistant (XDR). Cefiderocol is a novel antimicrobial that has been shown to overcome most carbapenemases, with very rare resistance reported to date. Within our institution, two multidrug-resistant and one XDR strains were isolated from a patient who recently emigrated from India. Each isolate underwent whole-genome sequencing to resolve plasmids and determine phylogenetics, strain typing, and mechanisms of resistance...
March 25, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38526046/outcomes-by-candida-spp-in-the-restore-phase-3-trial-of-rezafungin-versus-caspofungin-for-candidemia-and-or-invasive-candidiasis
#38
JOURNAL ARTICLE
Jeffrey B Locke, Chris M Pillar, Mariana Castanheira, Cecilia G Carvalhaes, David Andes, Jalal A Aram, Christina Andrzejewski, Ken Bartizal, Anita F Das, Taylor Sandison, George R Thompson, Peter G Pappas
Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the Phase 3 ReSTORE study based on the primary endpoints of day 14 global cure and 30-day all-cause mortality. Here, an analysis of ReSTORE data evaluating efficacy outcomes by baseline Candida species is described. Susceptibility testing was performed for Candida species using the Clinical and Laboratory Standards Institute reference broth microdilution method...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38525234/antibiotic-resistance-of-gallibacterium-anatis-biovar-haemolytica-isolates-from-chickens
#39
JOURNAL ARTICLE
Olimpia Kursa, Grzegorz Tomczyk, Agata Sieczkowska, Anna Sawicka-Durkalec
INTRODUCTION: Gallibacterium anatis is an opportunistic bacteria inducing a range of clinical signs in poultry. Gallibacterium anatis strains show multidrug resistance to antibacterial substances. The purpose of this study was to examine the susceptibility of G. anatis biovar haemolytica isolates collected from the respiratory, reproduction and gastrointestinal tracts of chickens to different antibiotics from various classes. MATERIAL AND METHODS: Gallibacterium anatis biovar haemolytica was identified in tracheal swab and gastrointestinal and reproductive tract tissue samples from Polish layer and broiler chicken flocks...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38525046/genomic-characterization-of-a-multidrug-resistant-uropathogenic-escherichia-coli-and-evaluation-of-echeveria-plant-extracts-as-antibacterials
#40
JOURNAL ARTICLE
Ana M Castañeda-Meléndrez, José A Magaña-Lizárraga, Marcela Martínez-Valenzuela, Aldo F Clemente-Soto, Patricia C García-Cervantes, Francisco Delgado-Vargas, Rodolfo Bernal-Reynaga
Uropathogenic Escherichia coli (UPEC) is the most common bacterial agent associated with urinary tract infections, threatening public health systems with elevated medical costs and high morbidity rates. The successful establishment of the infection is associated with virulence factors encoded in its genome, in addition to antibacterial resistance genes, which could limit the treatment and resolution of the infection. In this sense, plant extracts from the genus Echeveria have traditionally been used to treat diverse infectious diseases...
2024: AIMS Microbiology
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