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https://www.readbyqxmd.com/read/29341805/a-case-study-approach-combined-with-modified-team-based-learning-to-teach-the-progression-of-metabolic-syndrome-to-type-2-diabetes
#1
Chaya Gopalan, William Kist
No abstract text is available yet for this article.
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29341804/benefits-and-logistics-of-nonpresenting-undergraduate-students-attending-a-professional-scientific-meeting
#2
Chaya Gopalan, Patricia A Halpin, Kathryn M S Johnson
No abstract text is available yet for this article.
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29327076/arms-down-cone-beam-ct-hepatic-angiography-performance-assessment-vascular-imaging-quality-and-imaging-artifacts
#3
Adrian J Gonzalez-Aguirre, Elena N Petre, Meier Hsu, Chaya S Moskowitz, Stephen B Solomon, Jeremy C Durack
INTRODUCTION: The practice of positioning patients' arms above the head during catheter-injected hepatic arterial phase cone beam CT (A-CBCT) imaging has been inherited from standard CT imaging due to image quality concerns, but interrupts workflow and extends procedure time. We sought to assess A-CBCT image quality and artifacts with arms extended above the head versus down by the side. METHODS: We performed an IRB approved retrospective evaluation of reformatted and 3D-volume rendered images from 91 consecutive A-CBCTs (43 arms up, 48 arms down) acquired during hepatic tumor arterial embolization procedures...
January 11, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29261151/iron-overload-and-chelation-therapy-in-non-transfusion-dependent-thalassemia
#4
REVIEW
Rayan Bou-Fakhredin, Abdul-Hamid Bazarbachi, Bachar Chaya, Joseph Sleiman, Maria Domenica Cappellini, Ali T Taher
Iron overload (IOL) due to increased intestinal iron absorption constitutes a major clinical problem in patients with non-transfusion-dependent thalassemia (NTDT), which is a cumulative process with advancing age. Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading...
December 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29260056/corneal-edema-and-keratitis-following-selective-laser-trabeculoplasty
#5
Erica Tan Liu, Loren S Seery, Analisa Arosemena, Tania Lamba, Craig J Chaya
Purpose: To describe three cases of keratitis following Selective Laser Trabeculoplasty (SLT). Observations: Three females with a history of glaucoma presented with corneal edema, keratitis (endothelial, epithelial) and decreased visual acuity shortly after SLT. There was variable resolution of symptoms after starting treatment with oral antiherpetics and topical steroids. Conclusions and importance: With the increase in usage of SLT as a treatment for glaucoma and subsequent reports of keratitis, it is imperative for ophthalmic surgeons to be aware of herpes simplex as a possible risk factor...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29234793/using-free-response-receiver-operating-characteristic-curves-to-assess-the-accuracy-of-machine-diagnosis-of-cancer
#6
COMMENT
Chaya S Moskowitz
No abstract text is available yet for this article.
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29183517/direct-penetration-of-the-anterior-abdominal-wall-by-a-perforated-neoplastic-acute-appendicitis
#7
Raj S Lingnurkar, Chaya Shwaartz, Celia M Divino
No abstract text is available yet for this article.
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29153365/comparison-of-screening-cedm-and-mri-for-women-at-increased-risk-for-breast-cancer-a-pilot-study
#8
Maxine S Jochelson, Katja Pinker, D David Dershaw, Mary Hughes, Girard F Gibbons, Kareem Rahbar, Mark E Robson, Debra A Mangino, Debra Goldman, Chaya S Moskowitz, Elizabeth A Morris, Janice S Sung
OBJECTIVES: Contrast enhanced digital mammography (CEDM) is a new breast imaging technology increasingly used in the diagnostic setting but its utility in the pure screening setting has not been reported. The goal of this pilot study is to prospectively compare screening CEDM to breast MRI in women with an increased risk for breast cancer. METHODS: In this IRB-approved HIPAA-compliant study, 318 women at increased breast cancer risk were consented (December 2012-May 2015) to undergo CEDM in addition to their scheduled MRI...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29059430/genome-wide-association-study-to-identify-susceptibility-loci-that-modify-radiation-related-risk-for-breast-cancer-after-childhood-cancer
#9
MULTICENTER STUDY
Lindsay M Morton, Joshua N Sampson, Gregory T Armstrong, Ting-Huei Chen, Melissa M Hudson, Eric Karlins, Casey L Dagnall, Shengchao Alfred Li, Carmen L Wilson, Deo Kumar Srivastava, Wei Liu, Guolian Kang, Kevin C Oeffinger, Tara O Henderson, Chaya S Moskowitz, Todd M Gibson, Diana M Merino, Jeannette R Wong, Sue Hammond, Joseph P Neglia, Lucie M Turcotte, Jeremy Miller, Laura Bowen, William A Wheeler, Wendy M Leisenring, John A Whitton, Laurie Burdette, Charles Chung, Belynda D Hicks, Kristine Jones, Mitchell J Machiela, Aurelie Vogt, Zhaoming Wang, Meredith Yeager, Geoffrey Neale, Matthew Lear, Louise C Strong, Yutaka Yasui, Marilyn Stovall, Rita E Weathers, Susan A Smith, Rebecca Howell, Stella M Davies, Gretchen A Radloff, Kenan Onel, Amy Berrington de González, Peter D Inskip, Preetha Rajaraman, Joseph F Fraumeni, Smita Bhatia, Stephen J Chanock, Margaret A Tucker, Leslie L Robison
Background: Childhood cancer survivors treated with chest-directed radiotherapy have substantially elevated risk for developing breast cancer. Although genetic susceptibility to breast cancer in the general population is well studied, large-scale evaluation of breast cancer susceptibility after chest-directed radiotherapy for childhood cancer is lacking. Methods: We conducted a genome-wide association study of breast cancer in female survivors of childhood cancer, pooling two cohorts with detailed treatment data and systematic, long-term follow-up: the Childhood Cancer Survivor Study and St...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29050968/discovery-and-electrophysiological-characterization-of-skf-32802-a-novel-herg-agonist-found-through-a-large-scale-structural-similarity-search
#10
Brian T Donovan, Deepak Bandyopadhyay, Chaya Duraiswami, Christopher J Nixon, Claire Y Townsend, Stan F Martens
Despite the importance of the hERG channel in drug discovery and the sizable number of antagonist molecules discovered, only a few hERG agonists have been discovered. Here we report a novel hERG agonist; SKF-32802 and a structural analog of the agonist NS3623, SB-335573. These were discovered through a similarity search of published hERG agonists. SKF-32802 incorporates an amide linker rather than NS3623's urea, resulting in a compound with a different mechanism of action. We find that both compounds decrease the time constant of open channel kinetics, increase the amplitude of the envelope of tails assay, mildly increased the amplitude of the IV curve, bind the hERG channel in either open or closed states, increase the plateau of the voltage dependence of activation and modulate the effects of the hERG antagonist, quinidine...
October 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29025425/prognostic-utility-of-differential-tissue-characterization-of-cardiac-neoplasm-and-thrombus-via-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-among-patients-with-advanced-systemic-cancer
#11
Angel T Chan, Andrew J Plodkowski, Shawn C Pun, Yuliya Lakhman, Darragh F Halpenny, Jiwon Kim, Samantha R Goldburg, Mathew J Matasar, Chaya S Moskowitz, Dipti Gupta, Richard Steingart, Jonathan W Weinsaft
BACKGROUND: Late gadolinium enhancement (LGE-) cardiovascular magnetic resonance (CMR) is well-validated for cardiac mass (CMASS) tissue characterization to differentiate neoplasm (CNEO) from thrombus (CTHR): Prognostic implications of CMASS subtypes among systemic cancer patients are unknown. METHODS: CMASS + patients and controls (CMASS -) matched for cancer diagnosis and stage underwent a standardized CMR protocol, including LGE-CMR (IR-GRE) for tissue characterization and balanced steady state free precession cine-CMR (SSFP) for cardiac structure/function...
October 12, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28989138/knowledge-attitude-and-practices-regarding-pharmacovigilance-and-adverse-drug-reaction-reporting-among-dental-students-in-a-teaching-hospital-jodhpur-india-a-cross-sectional-study
#12
Kumar G Chhabra, Ashish Sharma, Chaya Chhabra, J Jyothirmai Reddy, Shravani G Deolia, Yogesh Mittal
INTRODUCTION: This is a cross-sectional knowledge, attitude, and practices (KAPs) study on pharmacovigilance (PV) and adverse drug reaction (ADR) reporting among dental students in a teaching hospital in India. AIM: The aim of this study was to assess the KAP of dental students regarding PV, ADR reporting, and barriers toward the same. MATERIALS AND METHODS: A cross-sectional survey using a self-administered, investigator-developed, close-ended questionnaire was conducted in an academic dental hospital in India...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28976287/child-work-safety-on-the-farms-of-local-agricultural-market-producers-parent-and-child-perspectives
#13
Phillip Summers, Sara A Quandt, Chaya R Spears Johnson, Thomas A Arcury
Agriculture is a hazardous industry, yet there are few regulations on the ages at which children may engage in farm work. Local agricultural market producers (LAMP) are a growing subset of farmers within "sustainable agriculture" who engage in direct-to-consumer and direct-to-retailer enterprises. This study explores the occupational health and safety perceptions of parents and children for children who work on their families' LAMP farms. In-depth interviews were conducted with 12 parent-child dyads from LAMP farms in Illinois and North Carolina...
October 4, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28900001/samd7-is-a-cell-type-specific-prc1-component-essential-for-establishing-retinal-rod-photoreceptor-identity
#14
Yoshihiro Omori, Shun Kubo, Tetsuo Kon, Mayu Furuhashi, Hirotaka Narita, Taro Kominami, Akiko Ueno, Ryotaro Tsutsumi, Taro Chaya, Haruka Yamamoto, Isao Suetake, Shinji Ueno, Haruhiko Koseki, Atsushi Nakagawa, Takahisa Furukawa
Precise transcriptional regulation controlled by a transcription factor network is known to be crucial for establishing correct neuronal cell identities and functions in the CNS. In the retina, the expression of various cone and rod photoreceptor cell genes is regulated by multiple transcription factors; however, the role of epigenetic regulation in photoreceptor cell gene expression has been poorly understood. Here, we found that Samd7, a rod-enriched sterile alpha domain (SAM) domain protein, is essential for silencing nonrod gene expression through H3K27me3 regulation in rod photoreceptor cells...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28899920/the-trpm1-channel-is-required-for-development-of-the-rod-on-bipolar-cell-aii-amacrine-cell-pathway-in-the-retinal-circuit
#15
Takashi Kozuka, Taro Chaya, Fuminobu Tamalu, Mariko Shimada, Kayo Fujimaki-Aoba, Ryusuke Kuwahara, Shu-Ichi Watanabe, Takahisa Furukawa
Neurotransmission plays an essential role in neural circuit formation in the central nervous system (CNS). Although neurotransmission has been recently clarified as a key modulator of retinal circuit development, the roles of individual synaptic transmissions are not yet fully understood. In the current study, we investigated the role of neurotransmission from photoreceptor cells to ON bipolar cells in development using mutant mouse lines of both sexes in which this transmission is abrogated. We found that deletion of the ON bipolar cation channel TRPM1 results in the abnormal contraction of rod bipolar terminals and a decreased number of their synaptic connections with amacrine cells...
October 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28819456/therapeutic-effect-of-astroglia-like-mesenchymal-stem-cells-expressing-glutamate-transporter-in-a-genetic-rat-model-of-depression
#16
Amit Shwartz, Oshra Betzer, Noam Kronfeld, Gila Kazimirsky, Simona Cazacu, Susan Finniss, Hae Kyung Lee, Menachem Motiei, Shani Yael Dagan, Rachela Popovtzer, Chaya Brodie, Gal Yadid
Recent studies have proposed that abnormal glutamatergic neurotransmission and glial pathology play an important role in the etiology and manifestation of depression. It was postulated that restoration of normal glutamatergic transmission, by enhancing glutamate uptake, may have a beneficial effect on depression. We examined this hypothesis using unique human glial-like mesenchymal stem cells (MSCs), which in addition to inherent properties of migration to regions of injury and secretion of neurotrophic factors, were differentiated to express high levels of functional glutamate transporters (excitatory amino acid transporters; EAAT)...
2017: Theranostics
https://www.readbyqxmd.com/read/28804950/non-invasive-assessment-of-adrenocortical-function-as-a-measure-of-stress-in-the-endangered-golden-langur
#17
Jatin Sarmah, Chaya R Hazarika, Elizabeth V Berkeley, Stefanie B Ganswindt, Andre Ganswindt
The golden langur (Trachypithecus geei) is an endangered primate endemic to northern India and Bhutan. The main stressors to the species are habitat degradation and fragmentation. Non-invasive fecal glucocorticoid metabolite (fGCM) analysis is a powerful tool for assessing stress associated with environmental disturbances in wildlife. However, interspecific differences in glucocorticoid metabolism require careful selection of the antibody used in their quantification. The goals of this study were to: 1) validate an enzyme immunoassay (EIA) to determine fecal GC metabolite (fGCM) concentrations in the golden langur and 2) compare fGCM concentrations between golden langurs living under different environmental conditions...
July 2017: Zoo Biology
https://www.readbyqxmd.com/read/28794536/combined-spinal-epidural-anaesthesia-in-a-case-of-primigravida-with-coarctation-of-aorta-with-severe-hypertension-for-elective-lower-segment-caesarean-section
#18
Nupur Dua, Bk Ashok Kumar, S Chaya, Tejal N Jivrajani
No abstract text is available yet for this article.
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28766551/mutation-in-the-cox4i1-gene-is-associated-with-short-stature-poor-weight-gain-and-increased-chromosomal-breaks-simulating-fanconi-anemia
#19
Bassam Abu-Libdeh, Liza Douiev, Sarah Amro, Maher Shahrour, Asaf Ta-Shma, Chaya Miller, Orly Elpeleg, Ann Saada
We describe a novel autosomal recessive form of mitochondrial disease in a child with short stature, poor weight gain, and mild dysmorphic features with highly suspected Fanconi anemia due to a mutation in COX4I1 gene. Whole Exome Sequencing was performed then followed by Sanger confirmation, identified a K101N mutation in COX4I1, segregating with the disease. This nuclear gene encodes the common isoform of cytochrome c oxidase (COX) subunit 4 (COX 4-1), an integral regulatory part of COX (respiratory chain complex IV) the terminal electron acceptor of the mitochondrial respiratory chain...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28751349/challenges-and-pitfalls-of-antipsychotic-prescribing-in-people-with-learning-disability
#20
Regi T Alexander, Rohit Shankar, Sally A Cooper, Sabyasachi Bhaumik, Richard Hastings, Chaya L Kapugama, Samuel J Tromans, Ashok Roy
No abstract text is available yet for this article.
August 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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