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https://www.readbyqxmd.com/read/29783118/placenta-derived-mesenchymal-stromal-cells-and-their-exosomes-exert-therapeutic-effects-in-duchenne-muscular-dystrophy
#1
Ariel Bier, Peter Berenstein, Noam Kronfeld, Daria Morgoulis, Amotz Ziv-Av, Hodaya Goldstein, Gila Kazimirsky, Simona Cazacu, Rinat Meir, Rachela Popovtzer, Amir Dori, Chaya Brodie
Duchenne muscular dystrophy (DMD) is a degenerative lethal, X-linked disease of skeletal and cardiac muscles caused by mutations in the dystrophin gene. Cell therapy using different cell types, including mesenchymal stromal cells (MSCs), has been considered as a potential approach for the treatment of DMD. MSCs can be obtained from autologous sources such as bone marrow and adipose tissues or from allogeneic placenta and umbilical cord. The safety and therapeutic impact of these cells has been demonstrated in pre-clinical and clinical studies and their functions are attributed to paracrine effects that are mediated by secreted cytokines and extracellular vesicles...
May 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29775389/systematic-review-of-the-impact-of-cancer-survivorship-care-plans-on-health-outcomes-and-health-care-delivery
#2
Paul B Jacobsen, Antonio P DeRosa, Tara O Henderson, Deborah K Mayer, Chaya S Moskowitz, Electra D Paskett, Julia H Rowland
Purpose Numerous organizations recommend that patients with cancer receive a survivorship care plan (SCP) comprising a treatment summary and follow-up care plans. Among current barriers to implementation are providers' concerns about the strength of evidence that SCPs improve outcomes. This systematic review evaluates whether delivery of SCPs has a positive impact on health outcomes and health care delivery for cancer survivors. Methods Randomized and nonrandomized studies evaluating patient-reported outcomes, health care use, and disease outcomes after delivery of SCPs were identified by searching MEDLINE, Embase, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and Cochrane Library...
May 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29743760/antibiotic-prescription-organisms-and-its-resistance-pattern-in-patients-admitted-to-respiratory-icu-with-respiratory-infection-in-mysuru
#3
M Mahendra, B S Jayaraj, K S Lokesh, S K Chaya, Vivek Vardhan Veerapaneni, Sneha Limaye, Raja Dhar, Rajesh Swarnakar, Shrikant Ambalkar, P A Mahesh
Aim of Study: Respiratory infections account for significant morbidity, mortality and expenses to patients getting admitted to ICU. Antibiotic resistance is a major worldwide concern in ICU, including India. It is important to know the antibiotic prescribing pattern in ICU, organisms and its resistance pattern as there is sparse data on Indian ICUs. Materials and Methods: We conducted a prospective study from August 2015 to February 2016. All patients getting admitted to RICU with respiratory infection who were treated with antibiotics were included into study...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29738352/the-effect-of-obesity-on-the-quality-of-bowel-preparation-for-colonoscopy-results-from-a-large-observational-study
#4
Ava B Anklesaria, Elena A Ivanina, Kenechukwu O Chudy-Onwugaje, Kevin Tin, Chaya M Levine, Peter Homel, Mary Rojas, Ira E Mayer, Rabin Rahmani
BACKGROUND: Obesity has been linked to suboptimal bowel preparation but this association has not been conclusively investigated in prospective studies. GOALS: Our objective was to determine whether any relationship exists between obesity as measured by body mass index (BMI) and quality of bowel preparation. STUDY: Adult patients who presented for outpatient colonoscopy at a single urban ambulatory surgery center within a 6-month period and fulfilled inclusion criteria were prospectively enrolled for the study...
May 5, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29734907/omega-%C3%AE-pulley-plasty-for-surgical-management-of-dequervain-s-disease
#5
Joseph Bakhach, Bachar Chaya, Nazareth Papazian
BACKGROUND: DeQuervain tenosynovitis, refractory to medical conservative treatment, has been traditionally treated by a simple division of the pulley, a procedure associated with several complications. Many authors attempted to prevent these complications by describing techniques of pulley reconstruction after its release necessitating suturing the different flaps and subsequently promoting extensor tendons adhesions. The authors present an alternative procedure for the first extensor compartment pulley decompression: "Omegaplasty"...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29590622/lrit1-a-retinal-transmembrane-protein-regulates-selective-synapse-formation-in-cone-photoreceptor-cells-and-visual-acuity
#6
Akiko Ueno, Yoshihiro Omori, Yuko Sugita, Satoshi Watanabe, Taro Chaya, Takashi Kozuka, Tetsuo Kon, Satoyo Yoshida, Kenji Matsushita, Ryusuke Kuwahara, Naoko Kajimura, Yasushi Okada, Takahisa Furukawa
In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells. However, the mechanisms underlying selective synapse formation in the cone photoreceptor pathway remain poorly understood. Here, we found that Lrit1, a leucine-rich transmembrane protein, localizes to the photoreceptor synaptic terminal and regulates the synaptic connection between cone photoreceptors and cone ON-bipolar cells. Lrit1-deficient retinas exhibit an aberrant morphology of cone photoreceptor pedicles, as well as an impairment of signal transmission from cone photoreceptors to cone ON-bipolar cells...
March 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29582826/actinomycetes-canaliculitis-complicating-congenital-nasolacrimal-duct-obstruction-in-an-infant
#7
Akshay Gopinathan Nair, Nayana A Potdar, Swaranjali S Gore, Amol Y Ganvir, Monisha K Apte, Trupti R Marathe, Chaya A Kumar, Chhaya A Shinde
Actinomyces israelii is a Gram-positive anaerobic organism commonly associated with canaliculitis in adults. Pediatric canaliculitis is relatively rare, especially in infancy. We report the case of an 11-month-old boy who presented with co-existing canaliculitis and congenital nasolacrimal obstruction. The presenting signs included epiphora, discharge, conjunctival congestion, and matting of lashes. On examination, punctual pouting, regurgitation, and yellow canaliculiths were noted. A punctoplasty and canalicular curettage were performed along with nasolacrimal probing...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29534953/radiographic-predictors-of-resectability-in-thymic-carcinoma
#8
Sara A Hayes, James Huang, Jennifer Golia Pernicka, Jane Cunningham, Junting Zheng, Chaya S Moskowitz, Michelle S Ginsberg
BACKGROUND: The aim of this study was to assess pre-operative computed tomography (CT) characteristics of thymic carcinomas and to investigate which features could predict an incomplete surgical resection. A secondary aim was to correlate pre-operative imaging features with Masaoka stage. METHODS: In this study, approved by our Institutional Review Board, two readers retrospectively reviewed pre-operative CTs at our tertiary referral oncology center between 1994 and 2014...
March 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29487247/body-plethysmography-in-chronic-obstructive-pulmonary-disease-patients-a-cross-sectional-study
#9
Yogesh Satyendra Gupta, Swati S Shah, Chaya K Ahire, Prathamesh Kamble, Anupam S Khare, S S More
Background: Chronic obstructive pulmonary disease (COPD) is the fourth most common cause of death in the world, for which smoking is a common cause. It is preferable to diagnose COPD at an earlier stage and to assess its progression so that mortality and morbidity of the disease could be reduced. Hence, we conducted this study to assess parameters of body plethysmography in Indian population where the data are lacking and to assess whether the use of body plethysmography can detect COPD earlier...
March 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29417654/prevalence-of-adverse-pathological-features-in-1-to-4-cm-low-risk-differentiated-thyroid-carcinoma
#10
Samskruthi P Murthy, Deepak Balasubramanian, Narayana Subramaniam, Gopalakrishnan Nair, Misha J C Babu, Priyank V Rathod, Krishnakumar Thankappan, Subramania Iyer, Smitha Nalumackal Vijayan, Chaya Prasad, Vasantha Nair
BACKGROUND: The American Thyroid Association (ATA) recommends thyroid lobectomy for 1 to 4 cm tumors without adverse features. We studied the prevalence of adverse pathological features in patients eligible for unilateral lobectomy. METHODS: We conducted a retrospective study of patients who underwent total thyroidectomy. Patients with differentiated thyroid cancer (DTC) with tumors measuring 1 to 4 cm with no known preoperative adverse features were included in this study...
February 8, 2018: Head & Neck
https://www.readbyqxmd.com/read/29387358/internal-preference-mapping-of-milk-fruit-beverages-influence-of-color-and-appearance-on-its-acceptability
#11
Rocío Fernández-Vázquez, Carla M Stinco, Dolores Hernanz Vila, Francisco J Heredia, Carolina Chaya, Isabel M Vicario
The individual preferences of 100 consumers between 20 and 30 years old for the color of 16 milk-fruit juice beverages (MFJB) were investigated by preference mapping technique. Consumers were asked to evaluate, just by looking at the samples, how much they liked them (from "Extremely dislike" to "Extremely like"). The color of the samples was analyzed by two different instrumental techniques. Results obtained from the instrumental color measurement showed the wide diversity in hues of the beverages available in the market, and correlations between techniques proved that both of them were appropriate to analyze color...
January 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29369490/neural-crest-emigration-from-start-to-stop
#12
REVIEW
Chaya Kalcheim
Within the dynamic context of a developing embryo, the multicellular patterns formed are extraordinarily precise. Through cell-cell communication, neighboring progenitors coordinate their activities, sequentially generating distinct tissues. The development of the dorsal neural tube remarkably illustrates this principle. It first generates neural crest (NC) cells, precursors of most of the peripheral nervous system, and then becomes the roof plate (RP) of the central nervous system. While the molecular network regulating emigration of NC progenitors has been extensively studied, the mechanisms by which dorsal neural tube precursors transit from an initial NC fate to a definitive RP identity remain widely open to investigation...
January 25, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29341805/a-case-study-approach-combined-with-modified-team-based-learning-to-teach-the-progression-of-metabolic-syndrome-to-type-2-diabetes
#13
Chaya Gopalan, William Kist
No abstract text is available yet for this article.
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29341804/benefits-and-logistics-of-nonpresenting-undergraduate-students-attending-a-professional-scientific-meeting
#14
Chaya Gopalan, Patricia A Halpin, Kathryn M S Johnson
No abstract text is available yet for this article.
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29327076/arms-down-cone-beam-ct-hepatic-angiography-performance-assessment-vascular-imaging-quality-and-imaging-artifacts
#15
Adrian J Gonzalez-Aguirre, Elena N Petre, Meier Hsu, Chaya S Moskowitz, Stephen B Solomon, Jeremy C Durack
INTRODUCTION: The practice of positioning patients' arms above the head during catheter-injected hepatic arterial phase cone beam CT (A-CBCT) imaging has been inherited from standard CT imaging due to image quality concerns, but interrupts workflow and extends procedure time. We sought to assess A-CBCT image quality and artifacts with arms extended above the head versus down by the side. METHODS: We performed an IRB approved retrospective evaluation of reformatted and 3D-volume rendered images from 91 consecutive A-CBCTs (43 arms up, 48 arms down) acquired during hepatic tumor arterial embolization procedures...
January 11, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29261151/iron-overload-and-chelation-therapy-in-non-transfusion-dependent-thalassemia
#16
REVIEW
Rayan Bou-Fakhredin, Abdul-Hamid Bazarbachi, Bachar Chaya, Joseph Sleiman, Maria Domenica Cappellini, Ali T Taher
Iron overload (IOL) due to increased intestinal iron absorption constitutes a major clinical problem in patients with non-transfusion-dependent thalassemia (NTDT), which is a cumulative process with advancing age. Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading...
December 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29260056/corneal-edema-and-keratitis-following-selective-laser-trabeculoplasty
#17
Erica Tan Liu, Loren S Seery, Analisa Arosemena, Tania Lamba, Craig J Chaya
Purpose: To describe three cases of keratitis following Selective Laser Trabeculoplasty (SLT). Observations: Three females with a history of glaucoma presented with corneal edema, keratitis (endothelial, epithelial) and decreased visual acuity shortly after SLT. There was variable resolution of symptoms after starting treatment with oral antiherpetics and topical steroids. Conclusions and importance: With the increase in usage of SLT as a treatment for glaucoma and subsequent reports of keratitis, it is imperative for ophthalmic surgeons to be aware of herpes simplex as a possible risk factor...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29234793/using-free-response-receiver-operating-characteristic-curves-to-assess-the-accuracy-of-machine-diagnosis-of-cancer
#18
COMMENT
Chaya S Moskowitz
No abstract text is available yet for this article.
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29183517/direct-penetration-of-the-anterior-abdominal-wall-by-a-perforated-neoplastic-acute-appendicitis
#19
Raj S Lingnurkar, Chaya Shwaartz, Celia M Divino
No abstract text is available yet for this article.
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29153365/comparison-of-screening-cedm-and-mri-for-women-at-increased-risk-for-breast-cancer-a-pilot-study
#20
Maxine S Jochelson, Katja Pinker, D David Dershaw, Mary Hughes, Girard F Gibbons, Kareem Rahbar, Mark E Robson, Debra A Mangino, Debra Goldman, Chaya S Moskowitz, Elizabeth A Morris, Janice S Sung
OBJECTIVES: Contrast enhanced digital mammography (CEDM) is a new breast imaging technology increasingly used in the diagnostic setting but its utility in the pure screening setting has not been reported. The goal of this pilot study is to prospectively compare screening CEDM to breast MRI in women with an increased risk for breast cancer. METHODS: In this IRB-approved HIPAA-compliant study, 318 women at increased breast cancer risk were consented (December 2012-May 2015) to undergo CEDM in addition to their scheduled MRI...
December 2017: European Journal of Radiology
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