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https://www.readbyqxmd.com/read/28647590/differences-in-the-coronal-proteome-acquired-by-particles-depositing-in-the-lungs-of-asthmatic-versus-healthy-humans
#1
Abhinav Kumar, Elif Melis Bicer, Paul Pfeffer, Marco P Monopoli, Kenneth A Dawson, Jonny Eriksson, Katarina Edwards, Steven Lynham, Matthew Arno, Annelie F Behndig, Anders Blomberg, Graham Somers, Dave Hassall, Lea Ann Dailey, Ben Forbes, Ian Mudway
Most inhaled nanomedicines in development are for the treatment of lung disease, yet little is known about their interaction with the respiratory tract lining fluids (RTLF). Here we combined the use of nano-silica, as a protein concentrator, with label-free snapshot proteomics (LC-MS/MS; key findings confirmed by ELISA) to generate a quantitative profile of the RTLF proteome and provided insight into the evolved corona; information that may be used in future to improve drug targeting to the lungs by inhaled medicines...
June 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28644378/an-energy-efficient-multi-tier-architecture-for-fall-detection-using-smartphones
#2
M Amac Guvensan, A Oguz Kansiz, N Cihan Camgoz, H Irem Turkmen, A Gokhan Yavuz, M Elif Karsligil
Automatic detection of fall events is vital to providing fast medical assistance to the causality, particularly when the injury causes loss of consciousness. Optimization of the energy consumption of mobile applications, especially those which run 24/7 in the background, is essential for longer use of smartphones. In order to improve energy-efficiency without compromising on the fall detection performance, we propose a novel 3-tier architecture that combines simple thresholding methods with machine learning algorithms...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28644251/risk-factors-etiological-classification-topographical-location-and-outcome-in-medullary-infarctions
#3
Elif Gökçal, Gözde Baran, Elvin Niftaliyev, Vildan Güzel, Talip Asil
An understanding of the etiological mechanisms is important for therapeutic decisions and prognostic evaluation of patients with ischemic stroke. The object of this study was to evaluate the risk factors, etiological subtypes, and topography of lesion in patients with medullary infarctions (MIs). Besides, we also investigated early neurological deterioration, new vascular events, and functional outcome of all patients at 3-month follow-up. We analyzed our database consisting of patients who were diagnosed with acute MI and who were admitted within 24 hours of onset...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28643749/treatment-of-high-risk-neuroblastoma-national-protocol-results-of-the-turkish-pediatric-oncology-group
#4
Serap Aksoylar, Ali Varan, Canan Vergin, Volkan Hazar, Ferhan Akici, Ayhan Dagdemir, Mustafa Buyukavci, Rejin Kebudi, Nilgun Kurucu, Betul Sevinir, Emel Unal, Sema Vural, Elif Guler, Hilmi Apak, Haldun Oniz, Ceyda Karadeniz, Cengiz Canpolat, Sema Anak, Inci Ilhan, Dilek Ince, Emre Cecen, Nur Olgun
BACKGROUND: The national protocol aimed to improve the outcome of the high risk neuroblastoma patients by high-dose chemotherapy and stem cell rescue with intensive multimodal therapy. MATERIALS AND METHODS: After the 6 induction chemotherapy cycles, patients without disease progression were nonrandomly (by physicians' and/or parent's choices) allocated into two treatment arms, which were designed to continue the conventional chemotherapy (CCT), or myeloablative therapy with autologous stem cell rescue (ASCR)...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28641778/clinical-presentations-metabolic-abnormalities-and-end-organ-complications-in-patients-with-familial-partial-lipodystrophy
#5
Baris Akinci, Huseyin Onay, Tevfik Demir, Şenay Savas-Erdeve, Ramazan Gen, Ilgin Yildirim Simsir, Fatma Ela Keskin, Mehmet Sercan Erturk, Ayse Kubat Uzum, Guzin Fidan Yaylali, Nilufer Kutbay Ozdemir, Tahir Atik, Samim Ozen, Banu Sarer Yurekli, Tugce Apaydin, Canan Altay, Gulcin Akinci, Leyla Demir, Abdurrahman Comlekci, Mustafa Secil, Elif Arioglu Oral
OBJECTIVE: Familial partial lipodystrophy (FPLD) is a rare genetic disorder characterized by partial lack of subcutaneous fat. METHODS: This multicenter prospective observational study included data from 56 subjects with FPLD (18 independent Turkish families). Thirty healthy controls were enrolled for comparison. RESULTS: Pathogenic variants of the LMNA gene were determined in nine families. Of those, typical exon 8 codon 482 pathogenic variants were identified in four families...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28639054/a-strong-relationship-between-oral-squamous-cell-carcinoma-and-dna-repair-genes
#6
Hakan Avci, Arzu Ergen, Elif Sinem Bireller, Baris Ertugrul, Bedia Cakmakoglu
Single nucleotide polymorphisms of DNA repair genes alter protein function and modulate DNA repair efficiency in various cancers. The X-ray repair cross-complementing group (XRCC) is responsible for the repair of DNA base damage and single-strand breaks. The aim of our study was to investigate the association of XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms with the susceptibility to develop oral squamous cell carcinoma (OSCC) in Turkish subjects. One hundred eleven patients with OSCC and 148 healthy controls were recruited for the study...
June 21, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28635538/clomipramine-trial-for-treatment-resistant-persistent-genital-arousal-disorder-a-case-series
#7
Ejder Akgun Yildirim, Munevver Hacioglu Yildirim, Elif Carpar, Irmak Sarac
INTRODUCTION: Treatment of persistent genital arousal disorder (PGAD), as a chronic and disabling condition, implicates substantial compelling complexities. METHODS: In this case series, seven women diagnosed with PGAD who were referred to the Sexual Dysfunction Unit of Psychotherapy Outpatient Clinic of Bakirkoy Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey between 2006 and 2009 were included. All patients were previously resistant to other antidepressants, antipsychotics and antiepileptics...
March 3, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28626204/intrapulpal-temperature-changes-during-curing-of-different-bulk-fill-restorative-materials
#8
Elif Yasa, Cigdem Atalayin, Gamze Karacolak, Tugrul Sari, L Sebnem Turkun
The aim of this study was to evaluate the intrapulpal temperature changes during the curing of different bulk-fill restorative materials. Ten mandibular molar teeth were selected and occlusal surfaces were removed to obtain a standard 0.5 mm occlusal dentin thickness. Five bulk-fill restorative materials and a conventional resin composite (control) were applied. The intrapulpal temperature changes during the curing of these materials were determined by a device simulating pulpal blood microcirculation. The difference between the initial and maximum temperature values (Δt), was recorded...
June 15, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28624626/alternative-polyadenylation-patterns-for-novel-gene-discovery-and-classification-in-cancer
#9
Oguzhan Begik, Merve Oyken, Tuna Cinkilli Alican, Tolga Can, Ayse Elif Erson-Bensan
Certain aspects of diagnosis, prognosis, and treatment of cancer patients are still important challenges to be addressed. Therefore, we propose a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden complexity in cancer transcriptomes, to further accelerate efforts to discover novel cancer genes and pathways. Here, we analyzed expression data for 1045 cancer patients and found a significant shift in usage of poly(A) signals in common tumor types (breast, colon, lung, prostate, gastric, and ovarian) compared to normal tissues...
June 15, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28621546/application-of-a-novel-phyco-composite-biosorbent-for-biotreatment-of-aqueous-medium-polluted-with-manganese-ions
#10
Fatih Deniz, Elif Tezel Ersanli
A composite phyco-biomass including four different marine macroalgae species (Chaetomorpha sp., Polysiphonia sp., Ulva sp. and Cystoseira sp.) was evaluated as a novel biosorbent for the biosorption of manganese ions from aqueous solution. The experimental studies were performed to optimize the operational factors including solution pH, biosorbent amount, initial manganese concentration and reaction time in a batch mode biosorption system. The removal yield of the biosorbent for manganese ions increased with increasing pH, manganese ion concentration and reaction time while it decreased as the biosorbent dose increased...
June 16, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28620755/predictive-value-of-mean-platelet-volume-for-pulmonary-embolism-recurrence
#11
Omer Araz, Fadime Sultan Albez, Elif Yilmazel Ucar, Bugra Kerget, Nafiye Yılmaz, Metin Akgun
PURPOSE: Recurrence is a major clinical problem in patients with pulmonary embolism and can affect mortality. The decision to discontinue treatment is important for recurrence and is based on patients' clinical features as well as certain blood parameters. Our aim in this study was to evaluate whether mean platelet volume (MPV) and platelet distribution width (PDW) have utility as new predictive parameters for recurrence and mortality in pulmonary embolism. MATERIALS AND METHODS: A total of 440 patients with pulmonary embolism underwent computed tomography, Doppler ultrasonography, and echocardiography before and at the conclusion of treatment...
June 15, 2017: Lung
https://www.readbyqxmd.com/read/28618761/the-effects-of-iloprost-and-alprostadil-on-ischemia-reperfusion-injury-in-preventing-inflammation-tissue-degeneration-and-apoptosis-in-rat-skeletal-muscle
#12
Elif Güneysu, Atacan Emre Koçman, Orhan Özatik, Cengiz Ovali, Betül Can, İbrahim Özkan Alataş, Mustafa Behçet Sevin
BACKGROUND/AIM: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury. MATERIALS AND METHODS: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618755/isolation-rates-and-antibiotic-susceptibilities-of-different-enterobacteriaceae-species-as-urinary-tract-infection-agents-in-turkey-a-systematic-review
#13
Caner Yürüyen, Yeşim Gürol, Sabire Ferda Kaleağasioğlu, Elif Çiğdem Kaspar, Gülden Yilmaz
BACKGROUND/AIM: In Turkey, few systematic reviews have analyzed the results of studies on the isolation rates of urinary tract infection agents and their antibiotic susceptibilities. This review was done to fill this gap and enable the correct application of guideline-based medical therapy by determining the isolation rates and antibiotic susceptibilities of different Enterobacteriaceae species in Turkey. MATERIALS AND METHODS: Relevant studies found from various databases with the help of previously specified search strategies were examined and eliminated according to eligibility criteria...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28612591/clinical-signif%C3%A4-cance-of-serum-ykl-40-chitinase-3-like-1-protein-as-a-biomarker-in-melanoma-an-analysis-of-112-turkish-patients
#14
Kayhan Erturk, Faruk Tas, Murat Serilmez, Elif Bilgin, Vildan Yasasever
Background: Angiogenesis plays an essential role in tumor growth and serum levels of YKL-40 , a strong angiogenic factor that promotes tumor vessel development, has been found to be elevated in various cancers. We here investigated correlation between melanoma parameters and serum YKL-40 levels, to assess potential diagnostic, prognostic and predictive values. Material and Methods: Data for 112 pathologically confirmed cutaneous melanomas of any stage were examined retrospectively. ELISA assays were used to measure serum YKL-40 in plasma samples...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28610712/the-effect-of-heating-rate-and-sintering-temperature-on-the-elastic-modulus-of-porcelain-tiles
#15
Elif Eren Gültekin
The scope of the present study is to investigate the change of elastic modulus with the physical and mechanical properties of porcelain tiles. In the study, porcelain tiles were sintered at different temperatures and at different heating rates to obtain minimum water absorption (%). After this, the time of flight of longitudinal and shear ultrasonic waves was measured through the tile. The time of flight of ultrasonic waves was measured using contact ultrasonic transducers operating on a pulse-echo mode. Using the time of flight of the ultrasonic waves and the thickness of the tiles, the velocity of the waves was determined...
June 3, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28610405/the-investigation-of-polymorphisms-in-dna-repair-genes-xrcc1-ape1-and-xpd-in-women-with-polycystic-ovary-syndrome
#16
Gonca Gulbay, Elif Yesilada, Onder Celik, Saim Yologlu
Background: PCOS was reported to arise from the interaction of genetic and environmental factors. Some studies reported that women with PCOS have DNA damage and chromosome breakage. Such studies bring to mind the genes that are involved in DNA repairing. At present, several DNA repair genes and, as products of these genes, certain polymorphisms that alter the activity of proteins are known in the literature. The aim of this dissertation is to study the genomic instability that have been reported in PCOS cases along with the relationship between XRCC1 Arg194Trp, XRCC1 Arg399Gln, APE1 Asp148Glu, and XPD Lys751Gln polymorphisms in order to contribute to the pathogenesis of PCOS...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28605288/neck-and-scapula-focused-exercise-training-on-patients-with-non-specific-neck-pain-a-randomized-controlled-trial
#17
Taha Ibrahim Yildiz, Elif Turgut, Irem Duzgun
OBJECTIVES: The purpose of this study was to investigate the effects of additional 6-week scapular stabilization training in patients with non-specific neck pain (NNP). MATERIALS AND METHOD: Thirty patients with non-specific neck pain were randomly allocated to the study. Fifteen participants in the intervention group (IG) received neck-focused exercise and scapular stabilization training while 15 participants in the control group(CG) received neck-focused exercise training...
June 12, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28605001/determination-of-structural-femoral-head-allograft-viability-and-integrity-with-a-novel-diagnostic-tool-spect-ct-a-preliminary-study
#18
Kasım Kilicarslan, Nadir Yalcin, Vedat Bicici, Elif Ozdemir, Izzet Bingol, Seyda Turkolmez
OBJECTIVE: To evaluate the viability and integrity of fresh frozen bulk femoral head allografts obtained from the institutional bone bank that were used to reconstruct severe acetabular defects and to validate the SPECT/CT method which gives both anatomical and functional data for this purpose. METHODS: We retrospectively reviewed 9 patients (6 female, 3 male; mean age 63.6 years). Preoperative and postoperative leg lengths, existence of the Trendelenburg sign, range of motion of the hip, visual analogue score (VAS), Harris Hip Score (HHS) and any complication were assesed at each follow-up...
June 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28602290/a-sensitive-and-disposable-electrochemical-immunosensor-for-detection-of-sox2-a-biomarker-of-cancer
#19
Elif Burcu Aydın, Mustafa Kemal Sezgintürk
A novel, sensitive, disposable indium tin oxide (ITO)-based electrochemical immunosensor was developed firstly for simple, rapid determination of Sex-determining region Y-box 2 (SOX2). SOX2 is a cancer biomarker and used for detecting small cell lung cancer, lung adenocarcinoma, squamous cell carcinoma, skin cancer, prostate cancer, and breast cancer. In this study, a disposable ITO thin film based electrode was used as working electrode for biosensing the interaction between SOX2 antigen and anti-SOX2 antibody...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28599176/a-highly-sensitive-immunosensor-based-on-ito-thin-films-covered-by-a-new-semi-conductive-conjugated-polymer-for-the-determination-of-tnf%C3%AE-in-human-saliva-and-serum-samples
#20
Elif Burcu Aydın, Muhammet Aydın, Mustafa Kemal Sezgintürk
A novel, ultrasensitive impedimetric immunosensor was constructed for the detection of tumor necrosis factor α (TNFα) by using Poly(3-thiophene acetic acid) (P3), a conjugated polymer as an immobilization matrix. The polymer P3 contains a lot of carboxylic acid groups on its surface that provide a larger biorecognition surface. This developed immunosensor was prepared on hydroxy-bearing ITO surface via an ester bond linkage of polymer P3 to immobilize anti-TNF α antibodies. The ITO electrode modification steps and interaction between anti-TNF α antibody and TNF α antigen were monitored by cyclic voltammetry (CV) and by electrochemical impedance spectroscopy (EIS) method...
June 2, 2017: Biosensors & Bioelectronics
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