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#1
Tamer Yoldas, Utku Arman Orun, Elif Sağsak, Zehra Aycan, Özkan Kaya, Senem Ozgur, Selmin Karademir
No abstract text is available yet for this article.
April 2018: Echocardiography
https://www.readbyqxmd.com/read/29678365/comparison-of-expulsions-following-intracesarean-placement-of-an-innovative-frameless-copper-releasing-iud-gyn-cs%C3%A2-versus-the-tcu380a-a-randomized-trial
#2
Ceren Unal, Ahmet Eser, Elif Tozkir, D Wildemeersch
OBJECTIVE: The intent of this study (primary outcome measure) is to assess the expulsion rate of a newly developed copper releasing frameless intrauterine IUD GyneFix® Cesarean Section (Gyn-CS®) at 3months' follow-up, compared to the TCu-380A IUD, inserted immediately postplacental expulsion following cesarean section delivery. STUDY DESIGN: This is a randomized trial from one hospital research center in Istanbul, Turkey. Eligible pregnant women, the majority undergoing elective cesarean delivery (n=106), and the remaining emergency cesarean section cases (n=34), received intracesarean insertion of Gyn-CS or TCu380A insertion...
April 17, 2018: Contraception
https://www.readbyqxmd.com/read/29676853/miniaturized-matrix-solid-phase-dispersion-coupled-with-supramolecular-solvent-based-microextraction-for-the-determination-of-paraben-preservatives-in-cream-samples
#3
Elif Yıldız, Hasan Çabuk
An analytical method is presented for the determination of paraben preservatives in semi-solid cream samples by matrix solid-phase dispersion combined with supramolecular solvent-based microextraction. Due to the oily and sticky nature of the sample matrix, parabens were first extracted from the samples by matrix solid-phase dispersion using silica as sorbent material with a clean-up performed with tetrahydrofuran in the elution step. The eluate (500 μL), 1-decanol (120 μL) and water (4.4 mL) were then mixed in a polyethylene pipette to form supramolecular solvent...
April 20, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29673665/diminished-ovarian-reserve-in-patients-with-psoriasis
#4
Burcu Tuğrul Ayanoğlu, Elif Didem Özdemir, Onur Türkoğlu, Aslıhan Alhan
OBJECTIVE: Psoriasis is a multi-systemic chronic inflammatory skin disease. Previous data suggests that women with some chronic inflammatory diseases have diminished ovarian reserve. This study explores ovarian reserve in patients with psoriasis. MATERIALS AND METHODS: We prospectively analyzed 14 female patients with psoriasis and 35 healthy age and body mass index matched controls. An interview explored demographic characteristics, obstetrical history and menstrual characteristics...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29663742/degenerative-effect-of-ankaferd-blood-stopper%C3%A2-on-mice-peripheral-sensory-neurons-in-vitro
#5
Ramazan Üstün, Elif Kaval Oğuz
Ankaferd Blood Stopper® (ABS) is a licensed medicinal herbal extract that ensures effective hemostasis on external, internal, postoperative and dental bleeds. Dorsal root ganglia (DRG) harbor cell bodies of peripheral sensory neurons. DRG neurons receive peripheral information and regularly send projections to nuclei in the brainstem and the spinal cord. These neurons play critical roles in neural development. Neuronal dysfunctions were reported due to ABS use in surgical interventions. The purpose of this experiment was to investigate the degenerative effects of the ABS on mice DRG cells <I>in vitro</I>...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29662552/strategies-for-enumeration-of-circulating-microvesicles-on-a-conventional-flow-cytometer-counting-beads-and-scatter-parameters
#6
Mohammad J Alkhatatbeh, Anoop K Enjeti, Sara Baqar, Elif I Ekinci, Dorothy Liu, Rick F Thorne, Lisa F Lincz
Enumeration of circulating microvesicles (MVs) by conventional flow cytometry is accomplished by the addition of a known amount of counting beads and calculated from the formula: MV/μl = (MV count/bead count) × final bead concentration. We sought to optimize each variable in the equation by determining the best parameters for detecting 'MV count' and examining the effects of different bead preparations and concentrations on the final calculation. Three commercially available bead preparations (TruCount, Flow-Count and CountBright) were tested, and MV detection on a BD FACSCanto was optimized for gating by either forward scatter (FSC) or side scatter (SSC); the results were compared by calculating different subsets of MV on a series of 74 typical patient plasma samples...
January 2018: Journal of Circulating Biomarkers
https://www.readbyqxmd.com/read/29659412/photodynamic-therapy-as-primary-treatment-for-small-choroidal-melanoma
#7
Elif B Turkoglu, Renelle Pointdujour-Lim, Arman Mashayekhi, Carol L Shields
PURPOSE: To report outcomes of photodynamic therapy (PDT) as primary treatment for small amelanotic choroidal melanoma. METHODS: Retrospective interventional case series of 12 patients with small choroidal melanoma treated with standard-fluence PDT (83 seconds; 50 J/cm) using verteporfin. OUTCOME MEASURES: Tumor regression, subretinal fluid resolution, best-corrected visual acuity, and PDT complications. RESULTS: There were 12 eyes with melanoma, demonstrating amelanotic (10 [83%]) or lightly pigmented (n = 2, 17%) appearance...
April 13, 2018: Retina
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#8
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29644599/long-term-effectiveness-and-safety-of-metreleptin-in-the-treatment-of-patients-with-generalized-lipodystrophy
#9
Rebecca J Brown, Elif A Oral, Elaine Cochran, David Araújo-Vilar, David B Savage, Alison Long, Gregory Fine, Taylor Salinardi, Phillip Gorden
PURPOSE: The purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquired generalized lipodystrophy. METHODS: Patients (n = 66) aged ≥6 months had lipodystrophy, low circulating leptin, and ≥1 metabolic abnormality (diabetes mellitus, insulin resistance, or hypertriglyceridemia). Metreleptin dose (once or twice daily) was titrated to a mean dose of 0.10 mg/kg/day with a maximum of 0.24 mg/kg/day...
April 12, 2018: Endocrine
https://www.readbyqxmd.com/read/29642826/-investigation-of-high-risk-st131-clone-in-esbl-producing-escherichia-coli-isolates-isolated-from-urine-and-non-urinary-clinical-specimens-with-maldi-tof-ms-and-real-time-pcr
#10
Zeynep Çizmeci, Barış Otlu, Elif Aktaş, Seyhan Ördekçi, Özlem Açıkgöz, Nuray Güleç
In recent years, the ST131 clone was identified as a high risk pandemic clone among Escherichia coli isolates by multilocus sequence typing (MLST) studies and has been associated with extended spectrum beta-lactamase (ESBL) production (often with CTX-M-15) and antibiotic resistance especially against fluoroquinolones. The aim of this study was to determine the rate of high risk ST131 clone in ESBL producing E.coli isolates in our region, to investigate the sensitivity of MALDI-TOF MS in the detection of ST131 clone, and to compare the frequency of antimicrobial resistance among ST131 and non-ST131 isolates...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29623728/poorly-differentiated-chordomas-showing-loss-of-ini1-smarcb1-a-report-of-2-rare-cases-with-diagnostic-implications
#11
Bharat Rekhi, Kemal Kosemehmetoglu, Swapnil Rane, Figen Soylemezoglu, Elif Bulut
Poorly differentiated chordomas are rare musculoskeletal tumors. Case 1. A 42-year-old lady presented with quadriparesis of 2 months' duration. Radiologic imaging disclosed a soft tissue mass in her left prevertebral- and paravertebral cervical region. Case 2. A 4-year-old male child presented with neck pain and restricted head movements of 1-year duration. Radiologic imaging revealed a contrast enhancing, paraspinal soft tissue mass in his cervical region. Microscopic examination in both the cases revealed a cellular malignant tumor composed of moderate to markedly pleomorphic cells with interspersed mitotic figures, along with focal myxoid change and necrosis...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29620591/a-new-comorbidity-in-female-patients-with-ankylosing-spondylitis-pelvic-organ-prolapse
#12
Mehmet Çağlayan, Pelin Oktayoğlu, Elif Ağaçayak, Abdullah Zübeyir Dagli, Mehmet Okçu, Kemal Nas
AIM: The aim of this study was to investigate whether increased intra-abdominal pressure caused by pelvic inflammation and frequent use of the Valsalva maneuver increases the incidence of pelvic organ prolapse (POP) among female patients with ankylosing spondylitis (AS). METHODS: Thirty-nine patients diagnosed as having AS through the use of the modified New York criteria, 47 patients with chronic low-back pain (CLBP), and 38 healthy controls (HCs) were included in this study...
March 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29620137/effectiveness-of-wii-based-rehabilitation-in-stroke-a-randomized-controlled-study
#13
Ayça Utkan Karasu, Elif Balevi Batur, Gülçin Kaymak Karataş
OBJECTIVE: To investigate the efficacy of Nintendo Wii Fit®-based balance rehabilitation as an adjunc-tive therapy to conventional rehabilitation in stroke patients. METHODS: During the study period, 70 stroke patients were evaluated. Of these, 23 who met the study criteria were randomly assigned to either the experimental group (n = 12) or the control group (n = 11) by block randomization. Primary outcome measures were Berg Balance Scale, Functional Reach Test, Postural Assessment Scale for Stroke Patients, Timed Up and Go Test and Static Balance Index...
April 5, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29616918/part-of-the-research-family
#14
Emma Pewsey
eLife is publishing a collection of articles and interviews with scientists who are parents to explore how to get the best of both worlds.
April 4, 2018: ELife
https://www.readbyqxmd.com/read/29615917/advances-in-glioblastoma-multiforme-treatment-new-models-for-nanoparticle-therapy
#15
REVIEW
Elif Ozdemir-Kaynak, Amina A Qutub, Ozlem Yesil-Celiktas
The most lethal form of brain cancer, glioblastoma multiforme, is characterized by rapid growth and invasion facilitated by cell migration and degradation of the extracellular matrix. Despite technological advances in surgery and radio-chemotherapy, glioblastoma remains largely resistant to treatment. New approaches to study glioblastoma and to design optimized therapies are greatly needed. One such approach harnesses computational modeling to support the design and delivery of glioblastoma treatment. In this paper, we critically summarize current glioblastoma therapy, with a focus on emerging nanomedicine and therapies that capitalize on cell-specific signaling in glioblastoma...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29615544/is-there-a-relationship-between-resistin-levels-and-left-ventricular-end-diastolic-pressure
#16
Özge Turgay Yıldırım, Aylin Yıldırır, Leyla Elif Sade, Senem Has Hasırcı, Hatice Kozan, Emre Özçalık, Kaan Okyay, Uğur Abbas Bal, Alp Aydınalp, Haldun Müderrisoğlu
OBJECTIVE: Resistin, a cysteine-rich peptide, is associated with atherosclerosis and diabetes. Resistin levels increase corresponding to coronary artery disease (CAD) and heart failure severity. Since resistin level tends to elevate with symptomatic heart failure, it is expected to be associated with left ventricular end-diastolic pressure (LVEDP). However, there is no relevant literature on the relationship between resistin levels and LVEDP. We aimed to evaluate the association between resistin levels and LVEDP, severity of CAD, carotid intima-media thickness (CIMT), and echocardiographic diastolic dysfunction parameters...
April 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29610677/potential-association-of-lmna-associated-generalized-lipodystrophy-with-juvenile-dermatomyositis
#17
Melis Sahinoz, Shafaq Khairi, Ashley Cuttitta, Graham F Brady, Amit Rupani, Rasimcan Meral, Marwan K Tayeh, Peedikayil Thomas, Meredith Riebschleger, Sandra Camelo-Piragua, Jeffrey W Innis, M Bishr Omary, Daniel E Michele, Elif A Oral
Background: Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mutations in the lamin genes and cover a wide spectrum of diseases including muscular dystrophies and lipodystrophy. The p.T10I LMNA variant is associated with a phenotype of generalized lipodystrophy that has also been called atypical progeroid syndrome...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29608706/risks-and-outcomes-of-invasive-fungal-infections-in-pediatric-allogeneic-hematopoietic-stem-cell-transplant-recipients-receiving-fluconazole-prophylaxis-a-multicenter-cohort-study-by-the-turkish-pediatric-bone-marrow-transplantation-study-group
#18
Volkan Hazar, Gülsün Tezcan Karasu, Vedat Uygun, Gülyüz Öztürk, Suar Çaki Kiliç, Alphan Küpesiz, Hayriye Daloglu, Serap Aksoylar, Didem Atay, Elif Ünal Ince, Musa Karakükçü, Namik Özbek, Funda Tayfun, Savas Kansoy, Emel Özyürek, Arzu Akçay, Orhan Gürsel, Sule Haskologlu, Zühre Kaya, Sebnem Yilmaz, Atila Tanyeli, Akif Yesilipek
Invasive fungal infections (IFIs) are a major cause of infection-related morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Data from pediatric settings are scarce. To determine the incidence, risk factors and outcomes of IFIs in a 180-day period post-transplantation, 408 pediatric patients who underwent allogeneic HSCT were retrospectively analyzed. The study included only proven and probable IFIs. The cumulative incidences of IFI were 2.7%, 5.0%, and 6...
March 27, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29608093/megacystis-microcolon-intestinal-hypoperistalsis-syndrome-in-which-a-different-de-novo-actg2-gene-mutation-was-detected-a-case-report
#19
Elif Ünver Korğalı, Amine Yavuz, Cemile Ece Çağlar Şimşek, Cengiz Güney, Hande Küçük Kurtulgan, Burak Başer, Mehmet Haydar Atalar, Hatice Özer, Hatice Reyhan Eğilmez
INTRODUCTION: Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is characterized by bladder distension without urinary tract obstruction, decreased or absent intestinal peristalsis and microcolon. Although the definitive cause remains unknown, changes in the ACTG2 gene are thought to be responsible for the intestinal and bladder hypoperistalsis. CASE REPORT: This female newborn with MMIHS had a c.532C>A /p.Arg178Ser heterozygous de novo mutation detected in the ACTG2 gene...
April 2, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29605570/a-new-hiv-1-rev-structure-optimizes-interaction-with-target-rna-rre-for-nuclear-export
#20
Norman R Watts, Elif Eren, Xiaolei Zhuang, Yun-Xing Wang, Alasdair C Steven, Paul T Wingfield
HIV-1 Rev mediates the nuclear export of unspliced and partially-spliced viral transcripts for the production of progeny genomes and structural proteins. In this process, four (or more) copies of Rev assemble onto a highly-structured 351-nt region in such viral transcripts, theRevresponseelement (RRE). How this occurs is not known. The Rev assembly domain has a helical-hairpin structure which associates through three (A-A, B-B and C-C) interfaces. The RRE has the topology of an upper-case letter A, with the two known Rev binding sites mapping onto the legs of the A...
March 29, 2018: Journal of Structural Biology
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