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Corey J Lager, Nazanene H Esfandiari, Yingying Luo, Angela R Subauste, Andrew T Kraftson, Morton B Brown, Oliver A Varban, Rasimcan Meral, Ruth B Cassidy, Catherine K Nay, Amy L Lockwood, Darlene Bellers, Colleen M Buda, Elif A Oral
BACKGROUND: Sleeve gastrectomy (LSG) is now the predominant bariatric surgery performed, yet there is limited long-term data comparing important outcomes between LSG and Roux-en-Y gastric bypass (RYGB). This study compares weight loss and impact on comorbidities of the two procedures. METHODS: We retrospectively evaluated weight, blood pressure, hemoglobin A1c, cholesterol, and medication use for hypertension, diabetes, and hyperlipidemia at 1-4 years post-operatively in 380 patients who underwent RYGB and 334 patients who underwent LSG at the University of Michigan from January 2008 to November 2013...
June 16, 2018: Obesity Surgery
Emrah Dagdeviren, Berna Aslan Çetin, Begum Aydogan Mathyk, Nadiye Koroglu, Elif Goknur Topcu, Mehmet Aytac Yuksel
PURPOSE: Induction of labor is a common practice in obstetrics. In recent years, a newer ultrasonographic parameter called the uterocervical angle (UCA) has been identified as a predictive tool for births. Our purpose is to investigate the role of UCA in predicting successful induction of labor. METHODS: The nulliparous term pregnancies (n:150) were grouped into successful/failed inductions of labor based on their progress into the active phase of labor after the administration of prostaglandin E2 (dinoprostone)...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Murat Mert Atmaca, Nerses Bebek, Elif Kocasoy-Orhan, Candan Gürses
OBJECTIVE: Epilepsia partialis continua (EPC) is a special form of cortical epilepsy. Several studies have described the ictal and interictal electroencephalography (EEG) findings in patients with EPC; however, lateralizing and localizing values of these findings have been evaluated rarely. This study investigated the correlation of semiologic and EEG findings, and outcomes in patients with EPC. PATIENTS AND METHODS: Clinical and EEG findings and outcomes, and their correlations were studied prospectively in 15 patients who were diagnosed as having EPC upon presentation to Istanbul Medical Faculty Hospital between January 2010 and April 2014, and retrospectively in 5 previously evaluated patients...
June 9, 2018: Clinical Neurology and Neurosurgery
Elif Engin, Rebecca S Benham, Uwe Rudolph
In the past 20 years we have learned a great deal about GABAA receptor (GABAA R) subtypes, and which behaviors are regulated or which drug effects are mediated by each subtype. However, the question of where GABAA Rs involved in specific drug effects and behaviors are located in the brain remains largely unanswered. We review here recent studies taking a circuit pharmacology approach to investigate the functions of GABAA R subtypes in specific brain circuits controlling fear, anxiety, learning, memory, reward, addiction, and stress-related behaviors...
May 25, 2018: Trends in Pharmacological Sciences
Elif Burcu Aydın, Mustafa Kemal Sezgintürk
In this study, we fabricated a sensitive and label-free impedimetric immunosensor based on 6-phosphonohexanoic acid (PHA) modified ITO electrode for detection of interleukin-8 (IL-8) in human serum and saliva. PHA was first employed to cancer biomarker sensing platform. Anti-IL-8 antibody was used as a biorecognition element and the detection principle of this immunosensor was based on monitoring specific interaction between anti-IL-8 antibody and IL-8 antigen. The morphological characterization of each electrode modification step was analyzed by scanning electron microscopy (SEM), SEM-energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) while electrochemical characterization was performed by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and single frequency impedance (SFI) techniques...
June 11, 2018: Analytical Biochemistry
Elif Öztürk Er, Emine Gülhan Bakırdere, Tuğçe Unutkan, Sezgin Bakırdere
A new competitive ligand has been synthesized for the preconcentration to obtain lower detection limits by using dispersive liquid-liquid microextraction combined with slotted quartz tube-flame atomic absorption spectrophotometry (DLLME-SQT-FAAS). The proposed method is simple, eco-friendly and has high sensitivity. The preconcentration procedure was optimized on the basis of various parameters affecting the complex formation and extraction efficiency such as pH and volume of buffer solution, volume of ligand solution, mixing period, volume and type of extraction solvent, volume and type of dispersive solvent, and salt effect...
September 2018: Journal of Trace Elements in Medicine and Biology
Tayfun Toptas, Elif Pestereli, Tayup Simsek, Selen Bozkurt, Gulgun Erdogan, Seyda Karaveli
Aims: To investigate whether the presence of serous tubal intraepithelial carcinoma (STIC) is associated with clinical outcomes in a nonselected (unknown BRCA status) cohort of patients with a high-grade serous carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. Settings and Design: A prospective case-series with planned data collection. Subjects and Methods: The study was conducted in a total of 131 patients, who underwent primary cytoreductive surgery between 2007 and 2012...
April 2018: Journal of Cancer Research and Therapeutics
Kıvılcım Karadeniz Cerit, Berna Karakoyun, Elif Bahadır, Meral Yüksel, Nurdan Bülbül, Feriha Ercan, E Tolga Dağlı, Berrak Ç Yeğen
BACKGROUND: The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. MATERIALS AND METHODS: Corrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3rd day (early group) or 28th day (late group), and treated daily with either saline or halofuginone (100 µg/kg/day; i...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
Sevil Ceyhan Doğan, Ahmet Karadağ, Kasım Durmuş, Özlem Şahin, Emine Elif Altuntaş
BACKROUND: The exact etiopathogenesis of fibromyalgia syndrome (FM) is still unclear but the pathogenesis of FM is associated with neurogenic inflammation. Allergic rhinitis (AR) is a common inflammatory and immunological disease of the nasal mucosa. As a result, it is known that neurogenic inflammation has a role in the pathophysiology of both FM and AR. OBJECTIVE: The aim of this study was to evaluate AR and nasal allergic inflammation using nasal mucociliary clearance time (NMC) in FM patients...
May 25, 2018: Journal of Back and Musculoskeletal Rehabilitation
Sibel Sak, Mert Barut, Hakim Celik, Adnan Incebiyik, Elif Ağaçayak, Hacer Uyanikoglu, Adnan Kirmit, Muhammet Sak
OBJECTIVE: The aim of this study was investigate the maternal serum concentrations of copper (Cu) and ceruloplasmin (CP) in patients with mild preeclampsia, severe preeclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and to determine their associations with the severity of the disease. METHODS: This study was carried out at the largest tertiary care health center in the southeast region in Turkey and Department of Obstetrics and Gynecology...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Elif Koeksoy, Maximilian Halama, Nikolas Hagemann, Pascal R Weigold, Katja Laufer, Sara Kleindienst, James M Byrne, Anneli Sundman, Kurt Hanselmann, Itay Halevy, Ronny Schoenberg, Kurt O Konhauser, Andreas Kappler
As a consequence of Earth's surface oxygenation, ocean geochemistry changed from ferruginous (iron(II)-rich) into more complex ferro-euxinic (iron(II)-sulphide-rich) conditions during the Paleoproterozoic. This transition must have had profound implications for the Proterozoic microbial community that existed within the ocean water and bottom sediment; in particular, iron-oxidizing bacteria likely had to compete with emerging sulphur-metabolizers. However, the nature of their coexistence and interaction remains speculative...
June 9, 2018: Geobiology
Arif Alper Cevik, Elif Dilek Cakal, Fikri M Abu-Zidan
BACKGROUND: The published recommendations for international emergency medicine curricula cover the content, but exclude teaching and learning methods, assessment, and evaluation. We aim to provide an overview on available emergency medicine clerkship curricula and report the development and application experience of our own curriculum. METHODS: Our curriculum is an outcome-based education, enriched by e-learning and various up-to-date pedagogic principles. RESULTS: Teaching and learning methods, assessment, and evaluation are described...
June 7, 2018: International Journal of Emergency Medicine
Mehmet Baysal, Elif G Ümit, Hakkı Onur Kırkızlar, Ali Caner Özdöver, Ahmet Muzaffer Demir
Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominantly inherited disorder characterized with bleeding episodes. These episodes tend to happen spontaneously and reduce the quality of life. Patients are often unresponsive to local measures. With the pathophysiological role of angiogenesis in HHT, antiangiogenic drugs including thalidomide were used to control bleeding episodes. In our study, we evaluated 6 patients with HHT, evaluated them with epistaxis severity score (ESS) and performed a quality of life assessment with 36 Item Short Form Questionnaire (SF-36) and the alterations of these evaluations with thalidomide treatment...
June 8, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Michelle Ma, Katie Falloon, Po-Hung Chen, Behnam Saberi, Aliaksei Pustavoitau, Elif Ozdogan, Zhiping Li, Benjamin Philosophe, Andrew M Cameron, Ahmet Gurakar
Acute alcoholic hepatitis is a syndrome of jaundice and hepatic decompensation that occurs with excessive alcohol consumption. The diagnosis can be made with a combination of clinical characteristics and laboratory studies, though biopsy may be required in unclear cases. Acute alcoholic hepatitis can range from mild to severe disease, as determined by a Maddrey discriminant function ≥32. Mild forms can be managed with supportive care and abstinence from alcohol. While mild form has an overall good prognosis, severe alcoholic hepatitis is associated with an extremely high short-term mortality of up to 50%...
January 1, 2018: Journal of Intensive Care Medicine
Çağla Serpil Doğan, Nevin Semerci Koyun, Gülşah Kaya Aksoy, Bülent Çekiç, Murat Savaş, Elif Çomak
OBJECTIVE: In this study, we aimed to assess renal outcomes of delayed diagnosis of dilating primary vesicoureteral reflux (VUR) following recurrent febrile urinary tract infections (fUTIs) and its diagnostic imaging procedures. MATERIAL AND METHODS: The medical records of patients who underwent ultrasonography (US), non- acute dimercaptosuccinic acid (Tc-99mDMSA) scintigraphy and voiding cystourethrography (VCUG), and who were older than 2 years at the time of VUR diagnosis were retrospectively reviewed...
May 31, 2018: Turkish Journal of Urology
Serhat Erol, Elif Sen, Yagmur Gizem Kilic, Ahmed Yousif, Oznur Akkoca Yildiz, Turan Acican, Sevgi Saryal
INTRODUCTION: In 2017 update, GOLD separated spirometry from ABCD classification. OBJECTIVES: The aim was to investigate the predictive reliability of GOLD 2017 grading system in terms of future moderate and severe exacerbations. METHODS: COPD patients were classified into A to D groups according to GOLD 2011 and 2017. Patients who were assigned to C/D groups according to GOLD 2011 were divided into subgroups C 1/D1, C2/D2, C3/D3 according to FEV1 % of predicted and exacerbation history...
June 5, 2018: Clinical Respiratory Journal
Toshitatsu Takao, Ryo Masumura, Sumitaka Sakauchi, Yoshiko Ohara, Elif Bilgic, Eiji Umegaki, Hiromu Kutsumi, Takeshi Azuma
Background and study aims:  We developed a new reporting system based on structured data entry, which selectively extracts only endoscopic findings from endoscopists' oral statements and automatically inputs them into appropriate columns in real time during endoscopic procedures. Methods:  We compared the time for endoscopic procedures and report preparation (ER time) by using an esophagogastroduodenoscopy simulator in three groups: one preparing reports using a mouse after endoscopic procedures (CE group); a second group preparing reports by using voice alone during endoscopic procedures (SR group); and the final group preparing reports by operating the system with a foot switch and inputting findings using voice during endoscopic procedures (SR + FS group)...
June 2018: Endoscopy International Open
Cangül Keskin, Uğur Inan, Duygu H Guler, Elif Kalyoncuoğlu
INTRODUCTION: The aim of this study was to compare the cyclic fatigue resistance of the ProTaper Gold (PTG; Dentsply Maillefer, Ballaigues, Switzerland), K3XF (SybronEndo, Orange, CA), and XP-endo Shaper (FKG Dentaire, La Chaux-de-Fond, Switzerland) nickel-titanium rotary instruments at intracanal temperatures. METHODS: Eighteen XP-endo Shaper (30.01), 18 K3XF (30.04), and 18 PTG F3 (30.09v) instruments were used to test the cyclic fatigue resistance at an intracanal temperature of 35° ± 2°C...
June 1, 2018: Journal of Endodontics
Elif Aybala Oktay, Huseyin Tort, Oguzhan Yıldız, Kemal Gokhan Ulusoy, Fulya Toksoy Topcu, Cigdem Ozer
Dental resin curing blue light (BL) is frequently used during treatments in dental clinics. However, little is known about the influence of BL irradiation on pulpal blood vessels. The aim of the present study was to investigate the mechanism of effect of BL irradiation on vascular tone. Rat aorta (RA) rings were irradiated with a BL source in organ baths, and the responses were recorded isometrically. Effect of BL irradiation on phenylephrine (PE) -precontraction and acetylcholine (ACh) -induced relaxation after PE -precontraction were obtained and compared in BL -irradiated and control RA rings...
May 26, 2018: Journal of Photochemistry and Photobiology. B, Biology
Cheri Hotu, Marc Rémond, Graeme Maguire, Elif Ekinci, Neale Cohen
OBJECTIVE: To determine the impact of an integrated diabetes service involving specialist outreach and primary health care teams on risk factors for micro- and macrovascular diabetes complications in three remote Indigenous Australian communities over a 12-month period. DESIGN: Quantitative, retrospective evaluation. SETTING: Primary health care clinics in remote Indigenous communities in Australia. PARTICIPANTS: One-hundred-and-twenty-four adults (including 123 Indigenous Australians; 76...
June 4, 2018: Australian Journal of Rural Health
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