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Meningeal carcinomatosis

Rema Rao, Syed A Hoda, Alan Marcus, Rana S Hoda
The incidence of metastatic carcinoma to the meninges ("meningeal carcinomatosis" [MC]) is increasing due to longer survival of patients and improved imaging techniques. Currently, MC is best diagnosed by cytopathological evaluation of cerebrospinal fluid (CSF). Breast primaries are the commonest cause of MC; although cytopathological features thereof have not been, as yet, fully characterized. In this study of meningeal mammary carcinomatosis, relevant clinicopathological data and archived cytopathological preparations of all "suspicious" and "positive" CSF specimens (1992-2015), from patients with a history of breast carcinoma, were retrieved and reviewed...
January 24, 2017: Breast Journal
Rohitashwa Dana, R K Spartacus, Shweta Mutha, Prashanth Bhat
Cisplatin and paclitaxel both can cause peripheral neurotoxicity as an adverse effect; however, central nervous system neurotoxicity in the form of seizures is rare. We report a case of a 36-year-old female patient of metastatic carcinoma cervix, who developed seizure shortly after cisplatin infusion. Her laboratory investigations were within normal limits. Computed tomography scan and magnetic resonance imaging of the brain did not reveal brain primary metastasis or meningeal carcinomatosis. She had no complaints of fever, no signs and symptoms of infection, and no history of seizure nor was she on any medication predisposing to such an event...
November 2016: Indian Journal of Pharmacology
W Gao, Z Li, L M Wang, F Lian, C C Liu, D H Lu, Y S Piao
Objective: To evaluate cytological test of cerebrospinal fluid in the diagnosis of meningeal dissemination of tumor cells. Methods: The clinical and imaging features of 85 cases with tumor cells diagnosed by thin-layer centrifugal cytological test of cerebrospinal fluid were retrospectively reviewed. The characteristics of cellular morphology and immunocytochemical staining were analyzed. Results: The main presentations of all the patinets was meningeal irritation and neurological dysfunction. The features of the brain MRI were meningeal thicking and enhancement, intracranial abnormal signals and intracranial space occupying lesion in part of the patients...
December 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
José Pedro Lavrador, Nuno Simas, Edson Oliveira, Manuel Herculano Carvalho
INTRODUCTION: Meningeal carcinomatosis is defined as tumour cells infiltration of leptomeninges and subarachnoid space. It is normally related with poor survival (2 - 5 months). The best multidisciplinary treatment for this condition is a matter of discussion. Patient's condition and the natural history of the disease should be considered in the decision making process. MATERIAL AND METHODS: Retrospective cohort analysis of patients submitted to Ommaya Reservoir placement due to systemic solid tumour meningeal carcinomatosis between 2006 and 2014...
August 2016: Acta Médica Portuguesa
Antonio Eduardo Zerati, Dafne Braga Diamante Leiderman, William Gemio Jacobsen Teixeira, Douglas Kenji Narazaki, Alexandre Fogaça Cristante, Nelson Wolosker, Nelson de Luccia, Tarcísio Eloy Pessoa de Barros Filho
OBJECTIVE: To describe the endovascular treatment of late aortic erosive lesion by pedicle screw without screw removal. DESIGN: Case report. METHODS AND RESULTS: A breast cancer patient had a pathological fracture on T10, with spinal cord compression, and a pseudoaneurysm of the aorta in contact with an anterolateral pedicle screw. Endovascular surgery corrected the aortic lesion and allowed decompression, a week later, by posterior arthrodesis (T7-L1), with screw maintainance...
September 22, 2016: Annals of Vascular Surgery
Xinfa Pan, Yongfu Lu, Liang Wen, Xiujue Zheng, Yuehui Ma
BACKGROUND: Timely diagnosis of meningeal carcinomatosis is often difficult even with the assistant of magnetic resonance imaging examination, cerebrospinal fluid analysis, or both. To the best of our knowledge, gadobutrol-enhanced MRI has not been reported in the diagnosis of meningeal carcinomatosis. Here we present two cases where meningeal carcinomatosis was identified on gadobutrol-enhanced magnetic resonance imaging. CASE PRESENTATION: We identified two cases of meningeal carcinomatosis who had been diagnosed with malignant tumors several years ago...
September 1, 2016: BMC Neurology
Keith Sacco, Aun Muhammad, Waqar Saleem, Heba Alshaker, Leonardo Monzon, Mohammad Rafiqul Islam, Dmitri Pchejetski
Leptomeningeal metastasis (LM) is an uncommon presentation of relapse in breast cancer, which is associated with poor clinical outcomes and poor prognosis. Notably, LM most commonly occurs in breast cancer. The aim of the present review was to investigate the occurrence of LM as the primary presentation of relapse following remission in breast cancer patients and to determine whether specific histological subtypes are predisposed to meningeal metastases. In addition, the present review evaluated whether patients presenting with LM as the primary site of relapse exhibit differences in survival when compared with patients exhibiting metastasis to other sites...
August 2016: Oncology Letters
A Defaee, I Mancini, X Vandemergel
We report the case of a patient presenting meningeal carcinomatosis and cutanenous metastasis as first manifestation of gastric adenocarcinoma. A 57-year-old patient was hospitalized because of headache and diplopia. Clinical examination revealed VI cranial nerve paralysis and anterior neck infiltration. Cutaneous biopsy and umbar puncture showed signet ring-cells. Extensive work-up disclosed gastric adenocarcinoma. Cutaneous metastasis and carcinomatous metastasis are both present exceptionally as first manifestation of gastric adenocarcinoma...
April 2016: Revue Médicale de Liège
Xi Wu, Junling Li, Jianping Xiao, Boyan Yang, Lei Yu, Xiaoming Wu, Jinghai Wan, Haiyan Xu, Jianxin Kong
BACKGROUND: Leptomeningeal carcinomatosis is a rare type of metastatic tumors of the central nervous system. In recent years, with the improvement of neoplasms therapies and longer survival of patients by better systemic control, incidence of leptomeningeal metastases has increased every year. However, there is still lack of effective therapies. The aim of this study is to investigate the efficacy, security and prognosis of intrathecal chemotherapy with methotrexate (MTX) in the treatment of neoplastic meningitis...
May 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Laura Mezquita-Pérez, Héctor Pian, Nuria García
No abstract text is available yet for this article.
November 2016: Archivos de Bronconeumología
P Lavaud, B Rousseau, Z Ajgal, J Arrondeau, O Huillard, J Alexandre, A Hulin, F Goldwasser
No abstract text is available yet for this article.
May 2016: Breast Cancer Research and Treatment
Qiang Shi, Chenglin Tian, Xusheng Huang, Chuanqiang Pu
BACKGROUND: Carcinoembryonic antigen (CEA) in cerebrospinal fluid (CSF) is important for the diagnosis of meningeal carcinomatosis. Its relationship with CSF and serum in non-neoplastic diseases may be beneficial for earlier diagnosis and treatment. METHODS: CSF samples were obtained from 346 non-neoplastic inpatients. Among them, 238 pairs of CSF and serum were obtained and compared. The 97.5(th) percentile and maximum value of CSF CEA were obtained. RESULTS: The 97...
2016: Annals of Clinical and Laboratory Science
Roosevelt Boursiquot, Danielle Krol, Sameul Hanif, Javier Rojas, Maneesh Jain
BACKGROUND: Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid. Incidence of leptomeningeal carcinomatosis arising from an esophageal cancer is particularly rare. CASE PRESENTATION: Here, we present a case report of a 76-year-old Caucasian man with a history of esophageal adenocarcinoma status-post chemoradiation followed by resection...
March 31, 2016: Journal of Medical Case Reports
Delphine Cochereau, Sabrina Da Costa, Christine Le Maignan, Hélène Gauthier, Jérôme Cochereau, Marc Espié, Sylvie Giacchetti, Luis Teixeira
Methotrexate represents the standard intrathecal treatment of breast cancer meningeal carcinomatosis. However, its optimal schedule remains undefined. The aim of the present study was to evaluate results obtained with the methotrexate schedule used in Saint-Louis hospital (Paris). Patients followed in Saint-Louis hospital for breast cancer and who received intrathecal methotrexate were included in this retrospective monocentric study. Intrathecal treatment received contained methotrexate 12 mg/day (days: 1-5) and then 15 mg/week until progression or toxicity...
May 2016: Bulletin du Cancer
Takahisa Yamasaki, Hirokazu Fukui, Hiroo Sei, Ken Hara, Hirotsugu Eda, Takashi Kondo, Fumihiko Toyoshima, Tomoaki Kono, Katsuyuki Tozawa, Hisatomo Ikehara, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroto Miwa
A 35-year-old man was diagnosed to have gastric cancer by endoscopic and histological examinations. Staging laparoscopy detected peritoneal metastasis. Systemic chemotherapy was started, but the patient complained of severe headache. Subsequently, a lumbar puncture demonstrated adenocarcinoma cells in the spinal fluid, suggesting the occurrence of meningeal carcinomatosis (MC) from gastric cancer. MC occurs only rarely in patients with gastric cancer, but the prognosis is invariably poor. However, this patient nevertheless survived for 12 months after receiving intrathecal MTX/Ara-C together with systemic chemotherapy...
2016: Internal Medicine
Victoria T Trinh, Rafael Medina-Flores, Muhammad O Chohan
Leptomeningeal carcinomatosis (LMC) is a rare complication of cancer that often presents at an advanced stage after obvious metastasis of a primary cancer or locally advanced disease. We present an uncommon case of LMC secondary to pancreatic carcinoma presenting with headache, unilateral VII nerve palsy, and lower extremity weakness. Initial cerebrospinal fluid (CSF) studies were concerning for chronic aseptic meningitis but negative for malignant cells; the diagnosis of tuberculous meningitis was erroneously evoked...
August 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yan Lyu, Chenghai Li, Xinhua Zhou, Wei He, Pingxin Lyu, Zhen Zhou, Dongpo Wang, Fenggang Ning, Yue Wang
OBJECTIVE: To investigate the MRI features of meningeal tuberculosis. METHODS: The MR images of meningeal tuberculosis were retrospectively analyzed in 147 patients who were clinically diagnosed from 2009 to 2014 years in our hospital, including 77 males, and 70 females. Their age ranged from 14 to 70 years, and the average age was(32 ± 13)years. All cases underwent MR plain scan and enhancement scan, and 26 cases underwent 3D TOF sequence and MRA vascular reconstruction...
November 2015: Chinese Journal of Tuberculosis and Respiratory Diseases
Tom W Swallow, Scott Mabbutt, Charles R W Bell
This case reports highlights a rare metastatic manifestation of transitional cell carcinoma of the bladder. The onset of symptoms associated with meningeal irritation should be investigated. However, there is little consensus in the treatment of leptomeningeal carcinomatosis and it should be considered a poor prognostic sign with symptomatic management.
November 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Mashrafi Ahmed, Tahmina Begum, Abdel Rahman Omer, Ishtiaque Amin Khan
A 47-year-old woman presented with headache, neck pain, dizziness, nausea and vomiting for 4-5 days. She also had a history of weight loss and difficulty in swallowing. On physical examination, she had nuchal rigidity with a positive Kernig's sign. Cerebrospinal fluid analysis revealed mild pleocytosis but some atypical cells were also noted. Cytopathological analysis of the atypical cells showed high nuclear/cytoplasmic ratios and eccentric nuclei with prominent nucleoli, consistent with malignancy. A CT scan of the head and neck showed multiple lytic lesions involving the left calvarium, and diffuse thickening and enhancement of meninges over the left cerebral area...
2016: BMJ Case Reports
Amol Raheja, Ilyas M Eli, Christian A Bowers, Cheryl Ann Palmer, William T Couldwell
BACKGROUND: Malignant degeneration of epidermoid cyst (EC) with accompanying leptomeningeal carcinomatosis (LC) at presentation is extremely rare. We add two cases to the literature, including the first case of primary brainstem involvement with simultaneous diffuse LC, and discuss clinical and radiological cues to differentiate benign and malignant epidermoid tumors for early diagnosis. CASE DESCRIPTION: The first patient in this report was a 54-year-old woman with recurrent aseptic meningitis and hydrocephalus...
April 2016: World Neurosurgery
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