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https://www.readbyqxmd.com/read/28110404/microrna-150-targets-elk1-and-modulates-the-apoptosis-induced-by-ox-ldl-in-endothelial-cells
#1
Bing Qin, Yaqing Shu, Li Xiao, Tingting Lu, Yinyao Lin, Huan Yang, Zhengqi Lu
Atherosclerosis, a chronic inflammatory disease, is the major cause of life-threatening complications such as myocardial infarction and stroke. Endothelial cells (ECs) apoptosis plays a vital role in the initiation and progression of atherosclerosis. Although a subset of microRNAs (miRNAs) have been identified as critical regulators of atherosclerosis, studies on their participation in endothelial apoptosis in atherosclerosis have been limited. In the current study, we show that miRNA-150 (miR-150) expression was substantially up-regulated during the oxidized low-density lipoprotein (ox-LDL)-induced apoptosis in human umbilical cord vein endothelial cells (HUVECs)...
January 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28110316/insensitivity-of-pi3k-akt-gsk3-signaling-in-peripheral-blood-mononuclear-cells-of-age-related-macular-degeneration-patients
#2
Liu Xunxian, Yao Zemin
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphatidylinositide 3-kinase (PI3K), Akt, and glycogen synthase kinase 3 (GSK3). We wondered whether or not altered PI3K, Akt, and GSK3 activities could be detected in peripheral blood mononuclear cells (PBMC) obtained from AMD patients...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28110114/tropoelastin-coated-plla-plga-scaffolds-promote-vascular-network-formation
#3
Shira Landau, Ariel A Szklanny, Giselle C Yeo, Yulia Shandalov, Elena Kosobrodova, Anthony S Weiss, Shulamit Levenberg
The robust repair of large wounds and tissue defects relies on blood flow. This vascularization is the major challenge faced by tissue engineering on the path to forming thick, implantable tissue constructs. Without this vasculature, oxygen and nutrients cannot reach the cells located far from host blood vessels. To make viable constructs, tissue engineering takes advantage of the mechanical properties of synthetic materials, while combining them with ECM proteins to create a natural environment for the tissue-specific cells...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28110074/covalently-immobilized-vegf-mimicking-peptide-with-gelatin-methacrylate-enhances-microvascularization-of-endothelial-cells
#4
S Prakash Parthiban, Deepti Rana, Esmaiel Jabbari, Nadia Benkirane-Jessel, Murugan Ramalingam
: Clinically usable tissue-engineered constructs are currently limited due to their inability of forming microvascular networks necessary for adequate cellular oxygen and nutrient supply upon implantation. The aim of this study is to investigate the conditions necessary for microvascularization in a tissue-engineered construct using vascular endothelial growth factor (VEGF). The construct was made of gelatin methacrylate (GelMA) based cell-laden hydrogel system, which was then covalently linked with VEGF-mimicking peptide (AcQK), using human umbilical vein endothelial cells (HUVECs) as the model cell...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28110073/sphingosine-1-phosphate-improves-endothelialization-with-reduction-of-thrombosis-in-recellularized-human-umbilical-vein-graft-by-inhibiting-syndecan-1-shedding-in-vitro
#5
Kai Hsia, Ming-Jie Yang, Wei-Min Chen, Chao-Ling Yao, Chih-Hsun Lin, Che-Chuan Loong, Yi-Long Huang, Ya-Ting Lin, Arthur D Lander, Hsinyu Lee, Jen-Her Lu
: Sphingosine-1-phosphate (S1P) has been known to promote endothelial cell (EC) proliferation and protect Syndecan-1 (SDC1) from shedding, thereby maintaining this antithrombotic signal. In the present study, we investigated the effect of S1P in the construction of a functional tissue-engineered blood vessel by using human endothelial cells and decellularized human umbilical vein (DHUV) scaffolds. Both human umbilical vein endothelial cells (HUVEC) and human cord blood derived endothelial progenitor cells (EPC) were seeded onto the scaffold with or without the S1P treatment...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28109962/endothelial-permeability-and-hemostasis-in-septic-shock-results-from-the-process-trial
#6
Peter Hou, Michael Filbin, Henry Wang, Long Ngo, David T Huang, William C Aird, Donald M Yealy, Derek C Angus, John A Kellum, Nathan I Shapiro
BACKGROUND: We studied patients from the Protocolized Care in Early Septic Shock (ProCESS) trial to determine: the effects of alternative resuscitation strategies on circulating markers of endothelial cell permeability and hemostasis, and; the association between biomarkers and mortality. METHODS: Prospective study of biomarkers of endothelial cell permeability (vegf, sflt-1, ang-2) and hemostasis (vwf, thrombomodulin, tpa) in 605 of the 1341 ProCESS participants in a derivation cohort and 305 in validation...
January 18, 2017: Chest
https://www.readbyqxmd.com/read/28109889/vascular-remodeling-a-redox-modulated-mechanism-of-vessel-caliber-regulation
#7
REVIEW
Leonardo Y Tanaka, Francisco R M Laurindo
Vascular remodeling, i.e. whole-vessel structural reshaping, determines lumen caliber in (patho)physiology. Here we review mechanisms underlying vessel remodeling, with emphasis in redox regulation. First, we discuss confusing terminology and focus on strictu sensu remodeling. Second, we propose a mechanobiological remodeling paradigm based on the concept of tensional homeostasis as a setpoint regulator. We first focus on shear-mediated models as prototypes of remodeling closely dominated by highly redox-sensitive endothelial function...
January 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28109806/momordica-charantia-polysaccharides-ameliorate-oxidative-stress-hyperlipidemia-inflammation-and-apoptosis-during-myocardial-infarction-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway
#8
Mohammad Raish
The polysaccharide extract of Momordica charantia has various biological activities; however, its effect on endothelial dysfunction in myocardial infarction remains unclear. To elucidate this, myocardial infarction was induced in rats using isoproterenol (ISP). Pretreatment with M. charantia polysaccharides (MCP; 150 or 300mg/kg) for 25days significantly inhibited increases in heart weight, the heart-weight-to-body-weight ratio, and infarction size, and ameliorated the increased serum levels of aspartate transaminase, creatine kinase, lactate dehydrogenase, total cholesterol, triglycerides, very-low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol...
January 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28109765/response-to-comment-to-the-article-diverse-contribution-of-bone-marrow-derived-late-outgrowth-endothelial-progenitor-cells-to-vascular-repair-under-pulmonary-arterial-hypertension-and-arterial-neointimal-formation
#9
Masayasu Ikutomi, Yoshiyasu Minami, Makoto Sahara
No abstract text is available yet for this article.
January 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28109704/nicotine-promotes-vascular-endothelial-growth-factor-secretion-by-human-trophoblast-cells-under-hypoxic-conditions-and-improves-the-proliferation-and-tube-formation-capacity-of-human-umbilical-endothelial-cells
#10
Hongbo Zhao, Lanxiang Wu, Yahui Wang, Jiayi Zhou, Ruixia Li, Jiabing Zhou, Zehua Wang, Congjian Xu
Pre-eclampsia, characterized as defective uteroplacental vascularization, remains the major cause of maternal and fetal mortality and morbidity. Previous epidemiological studies demonstrated that cigarette smoking reduced the risk of pre-eclampsia. However, the molecular mechanism remains elusive. In the present study, it is demonstrated that a low dose of nicotine decreased soluble vascular endothelial growth factor receptor 1 (sFlt1) secretion in human trophoblast cells under hypoxic conditions. Nicotine was then observed to promote vascular endothelial growth factor (VEGF) secretion by reducing sFlt1 secretion and increasing VEGF mRNA transcription...
January 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28109401/melanoma-last-call-for-radiotherapy
#11
REVIEW
Sophie Espenel, Alexis Vallard, Chloé Rancoule, Max-Adrien Garcia, Jean-Baptiste Guy, Cyrus Chargari, Eric Deutsch, Nicolas Magné
Melanoma is traditionally considered to be a radioresistant tumor. However, radiotherapy and immunotherapy latest developments might upset this radiobiological dogma. Stereotactic radiotherapy allows high dose per fraction delivery, with high dose rate. More DNA lethal damages, less sublethal damages reparation, endothelial cell apoptosis, and finally clonogenic cell dysfunction are produced, resulting in improved local control. Radiotherapy can also enhance immune responses, inducing neoantigens formation, tumor antigen presentation, and cytokines release...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28109307/novel-roles-of-dc-signr-in-colon-cancer-cell-adhesion-migration-invasion-and-liver-metastasis
#12
Heya Na, Xiaoli Liu, Xiaomeng Li, Xinsheng Zhang, Yu Wang, Zhaohui Wang, Menglang Yuan, Yu Zhang, Shuangyi Ren, Yunfei Zuo
BACKGROUND: Tumor metastasis is an essential cause of the poor prognosis of colon cancer. DC-SIGNR is a C-type lectin that is frequently found on human liver sinusoidal endothelial cells. LSECtin, which is a homologue of DC-SIGNR, has been demonstrated to participate in colon cancer liver metastasis. Due to the similarities in the expression pattern and structure of the two proteins, we speculated that DC-SIGNR could also be involved in this process. METHODS: Colon cancer cells were treated with the DC-SIGNR protein or control IgG, after which cell migration, invasion, and morphology were assayed...
January 21, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28109289/plantamajoside-from-plantago-asiatica-modulates-human-umbilical-vein-endothelial-cell-dysfunction-by-glyceraldehyde-induced-ages-via-mapk-nf-%C3%AE%C2%BAb
#13
Won-Rak Son, Mi-Hyun Nam, Chung-Oui Hong, Yoonsook Kim, Kwang-Won Lee
BACKGROUND: Plantago asiatica has been traditionally used for traditional medicine around East Asia. Plantamajoside (PM), which is isolated from this plant, is known for biological properties including anti-inflammation and antioxidant activity. To demonstrate the biological activity of PM against endothelial dysfunction induced by advanced glycation end-products (AGEs), a cellular inflammatory mechanism system was evaluated in human umbilical vein endothelial cells (HUVECs). METHODS: We obtained PM through previous research in our laboratory...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28109273/blocking-of-platelet-glycoprotein-receptor-ib-reduces-thrombo-inflammation-in-mice-with-acute-ischemic-stroke
#14
Michael K Schuhmann, Josua Guthmann, Guido Stoll, Bernhard Nieswandt, Peter Kraft, Christoph Kleinschnitz
BACKGROUND: Ischemic stroke causes a strong inflammatory response that includes T cells, monocytes/macrophages, and neutrophils. Interaction of these immune cells with platelets and endothelial cells facilitates microvascular dysfunction and leads to secondary infarct growth. We recently showed that blocking of platelet glycoprotein (GP) receptor Ib improves stroke outcome without increasing the risk of intracerebral hemorrhage. Until now, it has been unclear whether GPIb only mediates thrombus formation or also contributes to the pathophysiology of local inflammation...
January 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28109179/quantitative-and-integrative-analysis-of-paracrine-hepatocyte-activation-by-non-parenchymal-cells-upon-lipopolysaccharide-induction
#15
Katharina Beuke, Frank A Schildberg, Federico Pinna, Ute Albrecht, Roman Liebe, Michaela Bissinger, Peter Schirmacher, Steven Dooley, Johannes G Bode, Percy A Knolle, Ursula Kummer, Kai Breuhahn, Sven Sahle
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumor necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-κB pathway. The individual and cooperative impact of non-parenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter- and intracellular communication, we combined a multi-scale mathematical model with quantitative, time-resolved experimental data of different primary murine liver cell types...
January 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28109094/-lactobacillus-rhamnosus-gg-conditioned-medium-prevents-e-coli-meningitis-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-pathway
#16
Qing Zeng, Xiao-Long He, Han-Sheng Xiao, Lei DU, Yu-Jing Li, Le-Cheng Chen, Hui-Wen Tian, Sheng-He Huang, Hong Cao
OBJECTIVE: To investigate whether Lactobacillus rhamnosus GG conditioned medium(LGG-CM)has preventive effect against E. coli K1-induced neuropathogenicity in vitro by inhibiting nuclear factor-κB (NF-κB) signaling pathway. METHODS: An in vitro blood-brain barrier (BBB) model was constructed using human brain microvascular endothelial cells (HBMECs). The effect of LGG-CM on E. coli-actived NF-κB signaling pathway was assayed using Western blotting. Invasion assay and polymorphonuclear leukocyte (PMN) transmigration assay were performed to explore whether LGG-CM could inhibit E...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28108942/compartmentalized-culture-of-perivascular-stroma-and-endothelial-cells-in-a-microfluidic-model-of-the-human-endometrium
#17
Juan S Gnecco, Virginia Pensabene, David J Li, Tianbing Ding, Elliot E Hui, Kaylon L Bruner-Tran, Kevin G Osteen
The endometrium is the inner lining of the uterus. Following specific cyclic hormonal stimulation, endometrial stromal fibroblasts (stroma) and vascular endothelial cells exhibit morphological and biochemical changes to support embryo implantation and regulate vascular function, respectively. Herein, we integrated a resin-based porous membrane in a dual chamber microfluidic device in polydimethylsiloxane that allows long term in vitro co-culture of human endometrial stromal and endothelial cells. This transparent, 2-μm porous membrane separates the two chambers, allows for the diffusion of small molecules and enables high resolution bright field and fluorescent imaging...
January 20, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28108731/loss-of-endothelial-cell-specific-molecule-1-promotes-the-tumorigenicity-and-metastasis-of-prostate-cancer-cells-through-regulation-of-the-timp-1-mmp-9-expression
#18
Chien-Min Chen, Chu-Liang Lin, Hui-Ling Chiou, Shu-Ching Hsieh, Chia-Liang Lin, Chun-Wen Cheng, Chia-Hung Hung, Jen-Pi Tsai, Yi-Hsien Hsieh
The Endothelial cell specific molecule-1 (ESM1) protein has been involved in proliferation and metastatic progression in multiple tumors. However, there are no studies regarding the mechanism of ESM1 in prostate cancer. We found that ESM1 knockdown in prostate cancer cells resulted in increased cell proliferation and colony formation ability response evidenced by decreased expression of p21 and increased expression of cyclin D1 in prostate cancer cells. Moreover, we revealed that knockdown ESM1 also induced the epithelial-mesenchymal transition (EMT), motility and invasiveness in accordance with the upregulated the MMP-9 expression, while downregulated the TIMP-1 expression...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28108410/ganoderma-atrum-polysaccharide-ameliorates-anoxia-reoxygenation-mediated-oxidative-stress-and-apoptosis-in-human-umbilical-vein-endothelial-cells
#19
Yan-Song Zhang, Wen-Juan Li, Xian-Yi Zhang, Yu-Xin Yan, Shao-Ping Nie, De-Ming Gong, Xiao-Fang Tang, Ming He, Ming-Yong Xie
Ganoderma atrum polysaccharide (PSG-1), a main polysaccharide from Ganoderma atrum, possesses potent antioxidant capacity and cardiovascular benefits. The aim of this study was to investigate the role of PSG-1 in oxidative stress and apoptosis in human umbilical vein endothelial cells (HUVECs) under anoxia/reoxygenation (A/R) injury conditions. The results showed that exposure of HUVECs to A/R triggered cell death and apoptosis. Administration of PSG-1 significantly inhibited A/R-induced cell death and apoptosis in HUVECs...
January 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28108377/cucurbitacin-b-purified-from-ecballium-elaterium-l-a-rich-from-tunisia-inhibits-%C3%AE-5%C3%AE-1-integrin-mediated-adhesion-migration-proliferation-of-human-glioblastoma-cell-line-and-angiogenesis
#20
Imen Touihri-Barakati, Olfa Kallech-Ziri, Wiem Ayadi, Hervé Kovacic, Belgacem Hanchi, Karim Hosni, José Luis
Integrins are essential protagonists in the complex multistep process of cancer progression and are thus attractive targets for the development of anticancer agents. Cucurbitacin B, a triterpenoid purified from the leaves of Tunisian Ecballium elaterium exhibited an anticancer effect and displayed anti-integrin activity on human glioblastoma U87 cells, without being cytotoxic at concentrations up to 500nM. Here we show that cucurbitacin B affected the adhesion and migration of U87 cells to fibronectin in a dose-dependent manner with IC50 values of 86...
January 17, 2017: European Journal of Pharmacology
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