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https://www.readbyqxmd.com/read/28346435/aav9-mediated-engineering-of-autotransplanted-kidney-of-non-human-primates
#1
S Tomasoni, P Trionfini, N Azzollini, L Zentilin, M Giacca, S Aiello, L Longaretti, E Cozzi, N Baldan, G Remuzzi, A Benigni
Ex vivo gene transfer to the graft before transplantation is an attractive option for circumventing systemic side effects of chronic anti-rejection therapy. Gene delivery of the immunomodulatory protein CTLA4-Ig prevented chronic kidney rejection in a rat model of allotransplantation without the need for systemic immunosuppression. Here, we generated AAV2 and AAV9 vectors encoding for LEA29Y, an optimized version of CTLA4-Ig. Both LEA29Y vectors were equally efficient for reducing T-cell proliferation in vitro...
March 27, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28306518/biochemical-testing-in-a-laboratory-tent-and-semi-intensive-care-of-ebola-patients-on-site-in-a-remote-part-of-guinea-a-paradigm-shift-based-on-a-bleach-sensitive-point-of-care-device
#2
Leonid M Irenge, Jean-Michel Dindart, Jean-Luc Gala
BACKGROUND: During the West Africa Ebola virus disease (EVD) outbreak, a Belgian laboratory was deployed for supporting the Ebola treatment unit (ETU) of N'Zerekore, Guinea. Besides diagnosis of EVD and malaria, biochemical parameters were tested and used to guide supportive treatment of EVD. METHODS: To preserve analytes stability, lithium-heparin blood samples were analyzed using the i-STAT® point-of-care testing (POCT) handheld device without the viral inactivation step...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28209982/severe-decline-of-estimated-glomerular-filtration-rate-associates-with-progressive-cognitive-deterioration-in-the-elderly-a-community-based-cohort-study
#3
Yi-Chi Chen, Shuo-Chun Weng, Jia-Sin Liu, Han-Lin Chuang, Chih-Cheng Hsu, Der-Cherng Tarng
Cognitive dysfunction is closely related to aging and chronic kidney disease (CKD). However, the association between renal function changes and the risk of developing cognitive impairment has not been elucidated. This longitudinal cohort study was to determine the influence of annual percentage change in estimated glomerular filtration rate (eGFR) on subsequent cognitive deterioration or death of the elderly within the community. A total of 33,654 elders with eGFR measurements were extracted from the Taipei City Elderly Health Examination Database...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27979275/a-rapid-raman-detection-of-deoxynivalenol-in-agricultural-products
#4
Jing Yuan, Chuanwen Sun, Xiaoyu Guo, Tianxi Yang, Hui Wang, Shuyue Fu, Chuanchuan Li, Haifeng Yang
Mycotoxin results in financial damage and considerable safety risks. In this paper, the possibility of portable Raman system-based surface-enhanced Raman scattering (SERS) for a rapid detection of deoxynivalenol (DON) a mycotoxin in cereals was investigated. Under an optimized condition, SERS analysis for pure DON solution has a wide dynamic concentration range from 10(-7)M to 10(-2)M with the limit of detection (LOD) down to 100nM. Density functional theory (DFT) analysis at the level of B3LYP/6-311++G(d, p) was also preformed for vibrational assignment...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27976865/self-referenced-smartphone-based-nanoplasmonic-imaging-platform-for-colorimetric-biochemical-sensing
#5
Xinhao Wang, Te-Wei Chang, Guohong Lin, Manas Ranjan Gartia, Gang Logan Liu
Colorimetric sensors usually suffer due to errors from variation in light source intensity, the type of light source, the Bayer filter algorithm, and the sensitivity of the camera to incoming light. Here, we demonstrate a self-referenced portable smartphone-based plasmonic sensing platform integrated with an internal reference sample along with an image processing method to perform colorimetric sensing. Two sensing principles based on unique nanoplasmonics enabled phenomena from a nanostructured plasmonic sensor, named as nanoLCA (nano Lycurgus cup array), were demonstrated here for colorimetric biochemical sensing: liquid refractive index sensing and optical absorbance enhancement sensing...
December 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27860413/development-of-a-wearable-bioartificial-kidney-using-the-bioartificial-renal-epithelial-cell-system-brecs
#6
Kimberly A Johnston, Angela J Westover, Alvaro Rojas-Pena, Deborah A Buffington, Christopher J Pino, Peter L Smith, H David Humes
Cell therapy for the treatment of renal failure in the acute setting has proved successful, with therapeutic impact, yet development of a sustainable, portable bioartificial kidney for treatment of chronic renal failure has yet to be realized. Challenges in maintaining an anticoagulated blood circuit, the typical platform for solute clearance and support of the biological components, have posed a major hurdle in advancement of this technology. This group has developed a Bioartificial Renal Epithelial Cell System (BRECS) capable of differentiated renal cell function while sustained by body fluids other than blood...
November 18, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27677366/changes-in-body-composition-following-haemodialysis-as-assessed-by-bioimpedance-spectroscopy
#7
K Tangvoraphonkchai, A Davenport
BACKGROUND/OBJECTIVES: Patients with chronic kidney disease treated by haemodialysis (HD) are at increased risk of sarcopenia. Bioelectrical impedance spectroscopy (BIS) can be used to determine body composition, and is one of the several potential screening tools for sarcopenia. The newer generation of portable hand-held devices can be readily used in dialysis centres. The results from BIS devices using a two-compartmental model of body composition can be affected by hydration status and so ideally measurements should be made when patients are not overhydrated...
February 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27438878/diffusive-silicon-nanopore-membranes-for-hemodialysis-applications
#8
Steven Kim, Benjamin Feinberg, Rishi Kant, Benjamin Chui, Ken Goldman, Jaehyun Park, Willieford Moses, Charles Blaha, Zohora Iqbal, Clarence Chow, Nathan Wright, William H Fissell, Andrew Zydney, Shuvo Roy
Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million patients worldwide with end stage renal disease (ESRD). However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or other chronic illnesses. Additionally, the underlying membrane technology of polymer hollow-fiber membranes has not fundamentally changed in over four decades. Therefore, we have proposed a fundamentally different approach using microelectromechanical systems (MEMS) fabrication techniques to create thin-flat sheets of silicon-based membranes for implantable or portable hemodialysis applications...
2016: PloS One
https://www.readbyqxmd.com/read/27377897/incidences-of-acute-kidney-injury-dialysis-and-graft-loss-following-intravenous-administration-of-low-osmolality-iodinated-contrast-in-patients-with-kidney-transplants
#9
Ghaneh Fananapazir, Christoph Troppmann, Michael T Corwin, Arian M Nikpour, Sima Naderi, Ramit Lamba
PURPOSE: To determine the incidence of acute kidney injury (AKI), need for emergent dialysis, and renal graft loss in patients with kidney transplants, who underwent CT examinations with low-osmolality iodine-based contrast material (IBCM). MATERIALS AND METHODS: Our institutional review board approved this retrospective Health Insurance Portability and Accountability Act compliant study. From January 2005 to April 2015, a total of 224 CT examinations were performed using low-osmolality IBCM in patients with kidney transplants...
November 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27098797/resolvin-d1-protects-lipopolysaccharide-induced-acute-kidney-injury-by-down-regulating-nuclear-factor-kappa-b-signal-and-inhibiting-apoptosis
#10
Yu-Liang Zhao, Ling Zhang, Ying-Ying Yang, Yi Tang, Jiao-Jiao Zhou, Yu-Ying Feng, Tian-Lei Cui, Fang Liu, Ping Fu
BACKGROUND: Resolvin D1 (RvD1) is a newly found anti-inflammatory bioactive compound derived from polyunsaturated fatty acids. The current study aimed to explore the protective effect of RvD1 on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) and its possible mechanism. METHODS: Both in vivo and in vitro studies were conducted. Male BALB/c mice were randomly divided into control group (saline), LPS group (LPS 5 mg/kg), RvD1 group (RvD1 5 μg/kg + LPS 5 mg/kg), and blockage group (Boc-MLP 5 μg/kg + RvD1 5 μg/kg + LPS 5 mg/kg)...
May 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27007212/quantification-of-renal-steatosis-in-type-ii-diabetes-mellitus-using-dixon-based-mri
#11
Takeshi Yokoo, Haley R Clark, Ivan Pedrosa, Qing Yuan, Ivan Dimitrov, Yue Zhang, Ildiko Lingvay, Muhammad S Beg, I Alexandru Bobulescu
PURPOSE: To evaluate renal lipid content in subjects with and without type II diabetes mellitus (DM2) using Dixon-based magnetic resonance imaging (MRI). MATERIALS AND METHODS: This retrospective study was approved by the Institutional Review Board and compliant with the Health Insurance Portability and Accountability Act. Sixty-nine adults with or without DM2 (n = 29, n = 40) underwent 3T MRI of the abdomen using 3D multiecho Dixon gradient-echo acquisition and proton-density fat fraction (FF) reconstruction...
November 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/26989401/association-between-plaque-score-of-the-carotid-artery-and-the-severity-of-sleep-apnea-syndrome-in-patients-with-chronic-kidney-disease
#12
Daisuke Hasegawa, Akihito Tanaka, Daijo Inaguma, Eri Ito, Naoki Kamegai, Akiko Kato, Minami Mizutani, Hiroya Shimogushi, Hibiki Shinjo, Yasuhiro Otsuka, Asami Takeda
BACKGROUND: Recently, sleep apnea syndrome (SAS) has been associated with hypertension, cardiovascular disease and death. Patients with chronic kidney disease (CKD) have higher rates of SAS, atherosclerotic complications and death than do patients without CKD. Although the relationship between SAS and atherosclerosis is well known, few papers have described this relationship in humans, especially in CKD patients. PATIENTS AND METHODS: This was a cross-sectional study of 110 clinically stable, non-dialysis patients with CKD who attended a CKD educational program from April 2014 to September 2015...
February 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/26922119/practical-use-of-ultrasound-scan-in-small-ruminant-medicine-and-surgery
#13
REVIEW
Phil Scott
Modern portable ultrasound scan machines provide the veterinary clinician with an inexpensive and noninvasive method to further examine sheep on farms, which should take no more than 5 minutes with the results available immediately. Repeat examinations allow monitoring of the disease process and assessment of therapy. 5 MHz linear array scanners can be used for most organs except the heart and right kidney. Transthoracic ultrasonography is particularly useful for critical evaluation of lung and pleural pathologies...
March 2016: Veterinary Clinics of North America. Food Animal Practice
https://www.readbyqxmd.com/read/26913694/nanoporous-biomaterials-for-uremic-toxin-adsorption-in-artificial-kidney-systems-a-review
#14
Wee-Keat Cheah, Kunio Ishikawa, Radzali Othman, Fei-Yee Yeoh
Hemodialysis, one of the earliest artificial kidney systems, removes uremic toxins via diffusion through a semipermeable porous membrane into the dialysate fluid. Miniaturization of the present hemodialysis system into a portable and wearable device to maintain continuous removal of uremic toxins would require that the amount of dialysate used within a closed-system is greatly reduced. Diffused uremic toxins within a closed-system dialysate need to be removed to maintain the optimum concentration gradient for continuous uremic toxin removal by the dialyzer...
February 23, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/26686573/effect-of-permanent-atrial-fibrillation-on-cognitive-function-in-patients-with-chronic-heart-failure
#15
Maria Coma, Maria Jesús González-Moneo, Cristina Enjuanes, Paula Poveda Velázquez, Deva Bas Espargaró, Bernardo Andrés Pérez, Marta Tajes, Anna Garcia-Elias, Núria Farré, Gonzalo Sánchez-Benavides, Julio Martí-Almor, Josep Comin-Colet, Begoña Benito
In patients with chronic heart failure (HF), cognitive impairment (CI) is associated with poorer treatment adherence and higher readmission and mortality rates. Previous studies suggest that atrial fibrillation (AF) could impair cognitive function. This study sought to assess the association between permanent AF (permAF) and CI in patients with HF. We evaluated cognitive function in 881 patients with stable HF (73 ± 11 years, 44% women, 48% with preserved ejection fraction) using the Mini-Mental State Examination test (n = 876) and the Pfeiffer's Short Portable Mental Status Questionnaire (n = 848)...
January 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26656202/safety-report-of-ferumoxytol-for-magnetic-resonance-imaging-in-children-and-young-adults
#16
MULTICENTER STUDY
Anne M Muehe, Dan Feng, Rie von Eyben, Sandra Luna-Fineman, Michael P Link, Travis Muthig, Amy E Huddleston, Edward A Neuwelt, Heike E Daldrup-Link
OBJECTIVE: The aim of this study was to assess the safety profile of ferumoxytol as an intravenous magnetic resonance imaging contrast agent in children. MATERIALS AND METHODS: We prospectively evaluated the safety of ferumoxytol administrations as an "off-label" contrast agent for magnetic resonance imaging in nonrandomized phase 4 clinical trials at 2 centers. From September 2009 to February 2015, 49 pediatric patients (21 female and 28 male, 5-18 years) and 19 young adults (8 female and 11 male, 18-25 years) were reported under an investigator-initiated investigational new drug investigation with institutional review board approval, in health insurance portability and accountability act compliance, and after written informed consent of the child's legal representative or the competent adult patient was obtained...
April 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26607647/contrast-enhanced-ultrasound-ceus-in-blunt-abdominal-trauma
#17
REVIEW
Vittorio Miele, Claudia Lucia Piccolo, Michele Galluzzo, Stefania Ianniello, Barbara Sessa, Margherita Trinci
Baseline ultrasound is essential in the early assessment of patients with a huge haemoperitoneum undergoing an immediate abdominal surgery; nevertheless, even with a highly experienced operator, it is not sufficient to exclude parenchymal injuries. More recently, a new ultrasound technique using second generation contrast agents, named contrast-enhanced ultrasound (CEUS) has been developed. This technique allows all the vascular phase to be performed in real time, increasing ultrasound capability to detect parenchymal injuries, enhancing some qualitative findings, such as lesion extension, margins and its relationship with capsule and vessels...
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26582346/sleep-apnoea-is-a-risk-factor-for-acute-kidney-injury-after-coronary-artery-bypass-grafting
#18
Jieli Kua, Liang-Ping Zhao, Theodoros Kofidis, Siew-Pang Chan, Tiong-Cheng Yeo, Huay-Cheem Tan, Chi-Hang Lee
OBJECTIVES: Acute kidney injury (AKI) is a common complication in patients who undergo coronary artery bypass grafting (CABG). Sleep apnoea is associated with sympathetic activation, inflammatory reaction and plaque burden. The possible status of sleep apnoea as a risk factor for AKI after CABG has not been studied. METHODS: We recruited 169 patients for an overnight sleep study using a Food and Drug Administration-approved portable device before they underwent elective CABG...
April 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26241118/multiparametric-ultrasound-mpus-imaging-terminology-describing-the-many-aspects-of-ultrasonography
#19
COMPARATIVE STUDY
P S Sidhu
No abstract text is available yet for this article.
August 2015: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/26200202/portable-detection-of-melamine-in-milk-using-a-personal-glucose-meter-based-on-an-in-vitro-selected-structure-switching-aptamer
#20
Chunmei Gu, Tian Lan, Hanchang Shi, Yi Lu
Melamine detection in milk and other foods has attracted much attention since the discovery that melamine-adulterated food causes severe kidney damage. Although many methods have been developed to detect melamine, few methods can provide quantitative results using an affordable and portable device that is suitable for home use or field application. To achieve this goal, we herein report the first in vitro selection of a melamine responsive aptamer using a structure-switching method. A personal glucose meter (PGM) based melamine sensor was designed and subsequently tested using the newly isolated aptamer...
August 4, 2015: Analytical Chemistry
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