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https://www.readbyqxmd.com/read/29890232/pro-inflammatory-response-and-hemostatic-disorder-induced-by-venom-of-the-coral-snake-micrurus-tener-tener-in-c57bl-6-mice
#1
Emelyn Salazar, Ana Maria Salazar, Peter Taylor, Carlos Ibarra, Alexis Rodríguez-Acosta, Elda Sánchez, Karin Pérez, Beatriz Brito, Belsy Guerrero
Micrurus venoms are known to induce mainly neurotoxicity in victims. However, other manifestations, including hemorrhage, edema, myotoxicity, complement activation, and hemostatic activity have been reported. In order to develop a more complete pharmacological profile of these venoms, inflammatory responses and hemostasis were evaluated in C57BL/6 mice treated with a sub-lethal dose of M. t. tener (Mtt) venom (8 μg/mouse), inoculated intraperitoneally. The venom induced moderate bleeding into the abdominal cavity and lungs, as well as infiltration of leukocytes into the liver...
June 8, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29850133/the-influence-of-heparin-on-coagulation-function-of-patients-undergoing-video-assisted-major-thoracic-surgery
#2
Gu-Ha Alai, Han-Yu Deng, Gang Li, Jun Luo, Lun-Xu Liu, Yi-Dan Lin
Background: Venous thromboembolism (VTE) remains a common complication after major thoracic surgery, especially resection of lung or esophagus cancer. This trial aims to explore the influence of preoperative usage of heparin on coagulation function of patients treated with video-assisted major thoracic surgery. Methods: This prospective randomized control trial collected 91 patients who are diagnosed with lung or esophagus cancer intending to accept video-assisted neoplasm resection from June 2016 to May 2017 in West China Hospital, Sichuan University...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29850126/the-significance-of-perioperative-coagulation-and-fibrinolysis-related-parameters-after-lung-surgery-for-predicting-venous-thromboembolism-a-prospective-single-center-study
#3
Bo Tian, Chunfeng Song, Hui Li, Wenqian Zhang, Qirui Chen, Shuo Chen, Yili Fu, Xiaoxing Hu, Bin You, Tong Li, Bin Hu, Shengcai Hou
Background: The high incidence of venous thromboembolism (VTE) has been perceived in post thoracic surgery patients. However, the significance of perioperative coagulation and fibrinolysis related parameters after lung surgery for VTE predicting is not clear. To investigate that, we conducted a prospective single center study. Methods: A total of 111 patients undergoing lung surgery were enrolled in this study, included 52 primary lung cancer patients and 59 benign lung disease patients from July 2016 to March 2017...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29848060/international-normalized-ratio-relevance-to-the-observed-coagulation-abnormalities-in-warfarin-treatment-and-disseminated-intravascular-coagulation
#4
Amanda Walborn, Mark Williams, Jawed Fareed, Debra Hoppensteadt
The development of coagulation abnormalities is common in patients with sepsis. Sepsis-associated coagulopathy (SAC) is typically diagnosed by prothrombin time (PT) prolongation or elevated international normalized ratio (INR) in conjunction with reduced platelet count. INR is also used to monitor warfarin-treated patients. However, due to the different natures of SAC and warfarin anticoagulation, it is likely that the same INR value provides different information in these two patient populations. The purpose of this study was to compare measures of coagulation function and clotting factor levels in patients with SAC to those observed in patients receiving warfarin anticoagulation...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29808843/self-assembled-bivalent-aptamers-on-graphene-oxide-as-an-efficient-anticoagulant
#5
Pei-Xin Lai, Ju-Yi Mao, Binesh Unnikrishnan, Han-Wei Chu, Chien-Wei Wu, Huan-Tsung Chang, Chih-Ching Huang
Graphene oxide (GO) has unique structural properties, can effectively adsorb single-strand DNA through π-π stacking, hydrogen bonding and hydrophobic interactions, and is useful in many biotechnology applications. In this study, we developed a thrombin-binding-aptamers (15- and 29-mer) conjugated graphene oxide (TBA15/TBA29-GO) composite for the efficient inhibition of thrombin activity towards the formation of fibrin from fibrinogen. The TBA15/TBA29-GO composite was simply obtained by the self-assembly of TBA15/TBA29 hybrids on GO...
May 29, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29793324/evaluation-of-the-antithrombotic-activity-of-zhi-xiong-capsules-a-traditional-chinese-medicinal-formula-via-the-pathway-of-anti-coagulation-anti-platelet-activation-and-anti-fibrinolysis
#6
Jingjing Zhou, Zehai Song, Mingshu Han, Baoxing Yu, Guanghui Lv, Na Han, Zhihui Liu, Jun Yin
Zhi-Xiong Capsules (ZXC) involving Hirudo, Ligusticum chuanxiong, Salvia miltiorrhiza, Leonurus artemisia, and Pueraria lobata, is an empirical prescription used in Chinese clinics applied for treating cerebral arteriosclerosis and blood-stasis in clinic. However, the mechanism of its antithrombotic activity has not been investigated until now. The present study was designed to investigate its antithrombotic effects, the mechanism of ZXC on anti-thrombus action and to identify the main chemical composition of ZXC using HPLC-DAD-ESI-IT-TOF-MS...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29771870/hyperfibrinolysis-is-an-important-cause-of-early-hemorrhage-in-patients-with-acute-promyelocytic-leukemia
#7
Yu-Hua Song, Chun Qiao, Li-Chan Xiao, Run Zhang, Hua - Lu
BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in 112 newly-diagnosed patients with APL during induction treatment. RESULTS The early death (ED) rate in our study was 5.36% and the main cause was fetal hemorrhage. The presence of bleeding symptoms was significantly correlated with low platelet and fibrinogen levels...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29741463/influence-of-needle-gauge-used-for-venipuncture-on-measures-of-hemostasis-in-cats
#8
Susanna Solbak, Steven E Epstein, Kate Hopper
Objectives The objective of this study was to evaluate the effect of different needle sizes used to obtain blood via jugular venipuncture in cats on routine measures of hemostasis. Methods This was a prospective, observational, randomized, clinical study carried out at a university teaching hospital. Twenty healthy, client-owned cats were used. Results Each cat had blood collected via direct venipuncture from both jugular veins. Sampling of the right and left jugular vein was randomized to be collected with either a 22 G or a 25 G needle, respectively, and routine coagulation variables and platelet count were performed on all samples...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29708302/congenital-dysfibrinogenaemia-assessed-by-whole-blood-thromboelastography
#9
A Wei, L Liao, L Xiang, J Yan, W Yang, G Nai, M Luo, D Deng, F Lin
INTRODUCTION: Congenital dysfibrinogenaemia (CD) is a rare hereditary blood disorder, and thromboelastography (TEG) can comprehensively assess the clotting function of patients. However, only few studies have focussed on the application of TEG in CD. We aim to investigate the clinical value of TEG in congenital CD. METHODS: We performed TEG and routine coagulation tests, including plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), functional fibrinogen (Fg) concentration (Clauss method) and Fg concentration (PT-derived method) tests, in 17 patients with CD (experimental group) and 28 healthy individuals (control group)...
April 30, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29665924/-analysis-of-phenotype-and-l12r-mutation-in-signal-peptide-and-3-non-translation-region-c11814-insaa-mutation-of-f7-gene-in-a-family-with-hereditary-coagulation-factor-vii-deficiency
#10
Shan Liu, Jing-Yu Zhang, Zheng-Rong Li, Yan Wang, Zhi-Yun Niu, Feng-Ru Lin
OBJECTIVE: To examine one young female patient with hereditary FVII deficiency and her family members, to observe the gene mutation and clinical phenotype, and to investigate the molecular mechanism of the dysfunction. METHODS: Prothrombin time (PT), activated partial thromoploastin time (APTT), fibrinogen (Fg) and FVII activity (FVII:C) and FVII antigen (FVII:Ag) were tested. The gene mutations were sought by DNA sequencing for all of the exons and flanks, 5' and 3' non-translation region of F7 gene...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29656962/treatment-of-platelet-concentrates-and-plasma-with-riboflavin-and-uv-light-impact-in-bacterial-reduction
#11
J M Bello-López, L Delgado-Balbuena, D Rojas-Huidobro, J Rojo-Medina
OBJECTIVES: Transfusion of hemocomponents is essential for clinical and surgical procedures and therefore their safety has increased. An option for pathogen reduction includes the combination of riboflavin and UV light. To our knowledge, there are no studies in Latin America that demonstrate the effectiveness of the pathogen reduction in hemocomponents. The objective of this work was to evaluate the efficiency of a pathogens reduction system in platelets concentrates (PC) and plasma. MATERIALS AND METHODS: PC and plasma were contaminated with Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes and Staphylococcus epidermidis at 104 to 106  CFU and subjected to bacterial reduction...
April 12, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29652992/-phenotypic-and-mutational-analysis-of-a-pedigree-affected-with-hereditary-coagulation-factor-%C3%A2-deficiency
#12
Mengcha Tian, Hong Xia, Zhishan Zhang, Yanhui Jin, Kankan Su, Mingshan Wang
OBJECTIVE: To explore the molecular pathogenesis for a pedigree affected with coagulation factor Ⅴ (FⅤ) deficiency. METHODS: Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), coagulation factor Ⅱ activity (FⅡ: C), FⅤ activity (FⅤ: C), coagulation factor Ⅶ activity (FⅦ: C), and coagulation factor Ⅹ activity (FⅩ: C) were determined with a STAGO automatic coagulometer. FⅤ antigen (FⅤ: Ag) was detected with enzyme linked immunosorbent assay (ELISA)...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652987/-analysis-of-a-pedigree-affected-with-congenital-hypofibrinogenemia-due-to-heterozygous-ser313ile-mutation-of-fibrinogen-%C3%AE-chain-gene
#13
Liqing Zhu, Misheng Zhao, Xiaoli Cheng, Dandan Yu, Xiaolong Li, Fei Xu, Jinguo Wang, Mingshan Wang
OBJECTIVE: To explore the genetic basis for a Chinese pedigree affected with congenital hypofibrinogenamia. METHODS: Peripheral blood samples were collected from 9 members from the pedigree. Routine coagulation tests including activated partial thromboplastin time (APTT), thrombin time (TT), the prothrombin time (PT) were carried out. The activity of fibrinogen (Fg: C) was measured using Clauss method, and fibrinogen antigen (Fg: Ag) was measured with immunoturbidimetry...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652276/utility-of-thromboelastography-versus-routine-coagulation-tests-for-assessment-of-hypocoagulable-state-in-patients-undergoing-cardiac-bypass-surgery
#14
Seema Sharma, Sujeet Kumar, Prabhat Tewari, Shantanu Pande, Manjula Murari
Introduction: Peri-operative monitoring of coagulation is important to diagnose potential cause of hemorrhage, to manage coagulopathy and guide treatment with blood products in patients undergoing cardiac surgery with cardiopulmonary bypass. This study was done to evaluate usefulness of Thromboelastography (TEG) and routine coagulation tests (RCT) in assessing hemostatic changes and predicting postoperative bleeding in patients undergoing cardiac surgery with cardiopulmonary bypass. Methods: Fifty adult patients undergoing cardiac surgery with cardiopulmonary bypass were enrolled in this prospective study...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29648994/within-subject-biological-variation-of-activated-partial-thromboplastin-time-prothrombin-time-fibrinogen-factor-viii-and-von-willebrand-factor-in-pregnant-women
#15
Ann Helen Kristoffersen, Per Hyltoft Petersen, Line Bjørge, Thomas Røraas, Sverre Sandberg
BACKGROUND: During pregnancy, interpretation of results from coagulation parameters can be difficult as the physiological changes that occur may affect the biochemical parameters. The aim of this study was to describe the normal course of five coagulation parameters in healthy pregnancies, and to estimate the within-subject biological variation (CVI). METHODS: Blood samples were obtained every 4th week during pregnancy and three samples after delivery in 20 healthy women and every 4th week during a 40-week period in 19 healthy non-pregnant women...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29626437/dynamic-reference-intervals-for-coagulation-parameters-from-infancy-to-adolescence
#16
Christina Weidhofer, Elias Meyer, Robin Ristl, Helmut Wiedemann, Janne Cadamuro, Ulrike Kipman, Jakob Zierk, Christoph Male, Peter Quehenberger, Elisabeth Haschke-Becher, Elisa Einwallner
INTRODUCTION: Practical and ethical challenges as well as time and costs have restricted the generation of pediatric reference intervals. Therefore, pediatric reference intervals on coagulation parameters based on solid evidence are still scarce. Furthermore, reference intervals by age-group cannot reflect the dynamics of age and sex specific coagulation values during childhood. This study is the first to close this gap and provide continuous age and sex dependent reference intervals during childhood in hemostasis...
July 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29623883/evaluation-of-the-coagulometer-sta-r-max-%C3%A2-stago-for-routine-coagulation-parameters
#17
Justine Brulé, Thomas Sinegre, Bruno Pereira, Marc G Berger, Anne-Françoise Serre-Sapin, Aurélien Lebreton
The STA R Max® is a fully automated multiparameter coagulometer using clotting (viscosity-based detection system), chromogenic and immunologic assays. STA R Max® is equipped with an innovative software (STA Coag Expert® ) designed to assist laboratory in accreditation. The aim of this study was to evaluate its performances for the certification according to ISO 15189 quality standard in the haemostasis unit of our university hospital. The following tests were evaluated: prothrombin time (PT), activated partial thromboplastin time (aPTT), kaolin cephalin clotting time (KCCT), fibrinogen, anti-Xa assay and D-dimers...
April 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29622820/high-risk-of-coagulopathy-among-type-2-diabetes-mellitus-clients-at-a-municipal-hospital-in-ghana
#18
Richard Kd Ephraim, Yaw A Awuku, Patrick Adu, Lord Tw Ampomah, Prince Adoba, Solomon Panford, Jerry Pk Ninnoni, Hope Agbodzakey
Background: Persistent hyperglycaemia in diabetes mellitus causes coagulopathies due to glycation of haemoglobin, prothrombin, fibrinogen and other proteins involved in the clotting mechanism. Shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) reflect hypercoagulable state, which is associated with an increased thrombotic risk and adverse cardiovascular effects. This study assessed the coagulation profile of type 2 diabetes mellitus (T2DM) clients at a municipal hospital in Ghana...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29605959/heparin-induced-thrombocytopenia-in-infants-after-heart-surgery
#19
Juma N Abdillah, Qinghua Hu, Xuliang Chen, Xing Chen, Wu Zhou, Wanjun Luo, Lingjin Huang
BACKGROUND:  Heparin-induced thrombocytopenia (HIT) in infants is a rare disorder, and the diagnosis and management of HIT still remains challenging. Argatroban is a synthetic direct thrombin inhibitor (DTI) that is widely used for treating HIT. However, little is known about the efficacy of the activated clotting time (ACT) test in monitoring DTI treatment as an alternative to the routinely used activated partial thromboplastin time (aPTT). METHODS:  Between July 2013 and January 2015, four infants were diagnosed with HIT after surgical correction of congenital anomalies...
April 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29564685/an-increased-tendency-in-fibrinogen-activity-and-its-association-with-a-hypo-fibrinolytic-state-in-early-stages-after-injury-in-patients-without-acute-traumatic-coagulopathy-atc
#20
S He, M Blombäck, F Boström, H Wallen, J Svensson, A Östlund
Acute traumatic coagulopathy (ATC) diagnosed by prolongation of APTT and/or PT/INR involves alterations in platelet activity, coagulation and fibrinolysis. However, data showing the haemostatic situation in injured patients without ATC are scarce. To assess whether haemostatic impairment is also present in injured patients without ATC, ten injured patients without ATC and ten normal individuals were examined. The patients were sampled on arrival at the emergency department 0, 2, 12 h after surgical or other intervention...
May 2018: Journal of Thrombosis and Thrombolysis
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