Ivonne Bedei, Tascha Gehrke, Karl-Philipp Gloning, Matthias Meyer-Wittkopf, Daria Willner, Martin Krapp, Alexander Scharf, Jan Degenhardt, Kai-Sven Heling, Peter Kozlowski, Kathrin Trautmann, Kai M Jahns, Annegret Geipel, Jan-Erik Baumüller, Lucas Wilhelm, Ingo Gottschalk, Andreas Schröer, Alexander Graf, Aline Wolter, Johanna Schenk, Axel Weber, Ignatia B Van den Veyver, Roland Axt-Fliedner
OBJECTIVE: We aimed to investigate how the presence of fetal anomalies and different X chromosome variants influences Cell-free DNA (cfDNA) screening results for monosomy X. METHODS: From a multicenter retrospective survey on 673 pregnancies with prenatally suspected or confirmed Turner syndrome, we analyzed the subgroup for which prenatal cfDNA screening and karyotype results were available. A cfDNA screening result was defined as true positive (TP) when confirmatory testing showed 45,X or an X-chromosome variant...
February 2023: Prenatal Diagnosis