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Paracoccidioidomycosis

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https://www.readbyqxmd.com/read/29663530/geographical-evaluation-of-neuroparacoccidioidomycosis-and-paracoccidioidomycosis-in-southern-brazil
#1
Sergio Monteiro de Almeida, Gabriel L O Salvador, Thiago Henrique Roza, Luís Felipe Izycki, Isaias Dos Santos, Afonso Aragão, Amanda Kulik, Marisol Muro, Luis Fernando Bleggi Torres, Lucia Helena de Noronha
BACKGROUND: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis among immunocompetent patients in Latin America. OBJECTIVE: This study aimed to describe the expansion over time and the geographical distribution of confirmed Neuroparacoccidioidomycosis (NPCM) and PCM cases, and relate it to environmental characteristics such as climate, soil types, and coffee crops. METHODS: This was a retrospective study of autopsy and biopsy reports between 1951 and 2014 from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29649930/pulmonary-paracoccidioidomycosis-associated-with-the-use-of-natalizumab-in-multiple-sclerosis
#2
Kelson James Almeida, Raissa Viera Barreto-Soares, Raimundo Nonato Campos-Sousa, Maria Graças Campos-Sousa, Edson Bor-Seng-Shu
BACKGROUND: Natalizumab (NTZ) is a monoclonal antibody with an immunosuppressive effect that reduces the inflammation of the central nervous system, and it has been used for the treatment of relapsing-remitting multiple sclerosis (RRMS). In patients with low cellular immune response, systemic mycosis arising from endemic areas may occur. RESULTS AND CONCLUSION: In this article, we will describe a case of paracoccidioidomycosis as a complication to treatment with NTZ in an RRMS patient...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29616019/the-syk-coupled-c-type-lectin-receptors-dectin-2-and-dectin-3-are-involved-in-paracoccidioides-brasiliensis-recognition-by-human-plasmacytoid-dendritic-cells
#3
Nycolas Willian Preite, Claudia Feriotti, Dhêmerson Souza de Lima, Bruno Borges da Silva, Antônio Condino-Neto, Alessandra Pontillo, Vera Lúcia Garcia Calich, Flávio Vieira Loures
Plasmacytoid dendritic cells (pDCs), which have been extensively studied in the context of the immune response to viruses, have recently been implicated in host defense mechanisms against fungal infections. Nevertheless, the involvement of human pDCs during paracoccidioidomycosis (PCM), a fungal infection endemic to Latin America, has been scarcely studied. However, pDCs were found in the cutaneous lesions of PCM patients, and in pulmonary model of murine PCM these cells were shown to control disease severity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29565249/lobomycosis-like-disease-in-common-bottlenose-dolphins-tursiops-truncatus-from-belize-and-mexico-bridging-the-gap-between-the-americas
#4
Eric A Ramos, Delma N Castelblanco-Martínez, Jazmin Garcia, Jorge Rojas Arias, James R Foley, Katherina Audley, Koen Van Waerebeek, Marie-Françoise Van Bressem
Lobomycosis and lobomycosis-like diseases (LLD) (also: paracoccidioidomycosis) are chronic cutaneous infections that affect Delphinidae in tropical and subtropical regions worldwide. In the Americas, these diseases have been relatively well-described, but gaps still exist in our understanding of their distribution across the continent. Here we report on LLD affecting inshore bottlenose dolphins Tursiops truncatus from the Caribbean waters of Belize and from the eastern tropical Pacific Ocean off the southwestern coast of Mexico...
March 22, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#5
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29551333/scrotal-swelling-in-a-farmworker-with-paracoccidioidomycosis
#6
Daniella Braz Parente, Guilherme Felix Louza, Leonardo Hoehl Carneiro, Gláucia Zanetti, Edson Marchiori
No abstract text is available yet for this article.
March 15, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29518446/inhibition-of-protein-kinase-a-affects-paracoccidioides-lutzii-dimorphism
#7
Sheila J Sestari, Wesley A Brito, Bruno J Neves, Celia M A Soares, Silvia M Salem-Izacc
A critical step in the lifecycle of many fungal pathogens is the ability to switch between filamentous and yeast growth, a process known as dimorphism. cAMP-dependent protein kinase (PKA) controls morphological changes and the pathogenicity of several animal and plant pathogenic fungi. In this work, we report the analysis of PKA activity during the mycelium to yeast transition in the pathogenic fungus Paracoccidioides lutzii. This fungus, as well as the closely related species Paracoccidioides brasiliensis, causes paracoccidioidomycosis, a systemic mycosis that affects thousands of people in Latin America...
March 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29517539/67ga-scintigraphy-for-assessment-of-disease-severity-and-treatment-response-in-patients-with-paracoccidioidomycosis
#8
Lilian Yuri Itaya Yamaga, Gil Benard, Tomoco Watanabe, Marcelo Buarque de Gusmão Funari, Fausto Haruki Hironaka, Carlos Alberto Buchpighel, Maria Aparecida Shikanai Yasuda
OBJECTIVE: The evaluation of therapy response of patients with deep mycosis is a major challenge. The aim of this study was to assess the severity of disease at admission and evaluate treatment response of patients with paracoccidioidomycosis using Ga scintigraphy. SUBJECTS AND METHODS: Seventy-three patients with fully active disease were enrolled. A scoring system based on clinicoradiological and serological evaluation and Ga scan was devised. Pretherapy Ga score of 73 patients was compared with clinicoradiological and serological scores...
March 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29513831/fatal-septic-shock-caused-by-paracoccidioides-brasiliensis-phylogenetic-species-s1-in-a-young-immunocompetent-patient-a-case-report
#9
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Rowena Alves Coelho, Marcio Amaral de Oliveira Filho, Denise Machado Medeiros, Adriano Gomes-Silva, Jéssica Ribeiro de Lima, Alda Maria Da-Cruz, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29489507/sofat-as-a-putative-marker-of-osteoclasts-in-bone-lesions
#10
Lara E Cândido-Soares, Elizabeth F Martinez, Vera C de Araújo, Ney S Araújo, Nadir S Freitas, Marcelo H Napimoga
Secreted osteoclastogenic factor of activated T cells (SOFAT) is a novel activated human T-cell-secreted cytokine that induce osteoclastogenesis in a RANKL-independent manner. The aim of this study was to evaluate the immunohistochemical expression of SOFAT in intraosseous and extraosseous lesions. Thirty-two oral biopsies were divided into 2 groups: (1) intraosseous lesions-4 cases of cherubism, 5 central giant cell lesions, 3 osteoblastomas, 3 cementoblastomas, 2 periapical lesions and (2) extraosseous lesions-5 peripheral giant cell lesions, 5 cases of oral paracoccidioidomycosis, and 5 foreign body reactions...
February 27, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29453699/unusual-intestinal-involvement-by-paracoccidioidomycosis-diagnosed-after-oral-manifestation
#11
Rodrigo Neves-Silva, Patrícia Maria Fernandes, Alan Roger Santos-Silva, Pablo Agustin Vargas, Ricardo de Souza Cavalcante, Marcio Ajudarte Lopes
Paracoccidioidomycosis is a common deep fungus infection in South America, particularly in Brazil. It is acquired through inhalation and primary involvement of lungs. Subsequently, dissemination may occur and oral mucosa is frequently affected and actually, in most of the cases the diagnosis is established because of the oral lesions. Thus, the role of the dentist is fundamental to correct diagnosis. However, the involvement of intestine is rarely reported. The current case describes a 36-year-old man who presented abdominal pain and intestinal constipation, being suspected and then confirmed as paracoccidioidomycosis after already be diagnosed with this disease by a dentist through oral manifestations...
February 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29447170/imported-endemic-mycoses-in-spain-evolution-of-hospitalized-cases-clinical-characteristics-and-correlation-with-migratory-movements-1997-2014
#12
Daniel Molina-Morant, Adrián Sánchez-Montalvá, Fernando Salvador, Augusto Sao-Avilés, Israel Molina
Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to migration and temporary movements. We obtained from the Spanish hospitals records clinical and demographic data of all hospitalized cases between 1997 and 2014. There were 286 cases of histoplasmosis, 94 of Coccidioidomycosis and 25 of paracoccidioidomycosis...
February 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29420819/evaluation-of-the-hepatobiliary-system-in-patients-with-paracoccidioidomycosis-treated-with-cotrimoxazole-or-itraconazole
#13
Adriele Dandara Levorato, Daniela Vanessa Moris, Ricardo de Souza Cavalcante, Tatiane Fernanda Sylvestre, Priscila Zacarias de Azevedo, Lídia Raquel de Carvalho, Rinaldo Poncio Mendes
A prospective study was performed in 200 paracoccidioidomycosis (PCM) patients, 51 presenting the acute/subacute form (AF) and 149 the chronic form (CF), submitted to the evaluation of the hepatobiliary system at admission and during the follow-up treatment with cotrimoxazole (CMX) or itraconazole (ITC). This study aimed to better evaluate the involvement of the hepatobiliary system in PCM and the effect of these antifungal compounds on this system. Serum levels of direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were evaluated...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29420794/itraconazole-in-combination-with-neutrophil-depletion-reduces-the-expression-of-genes-related-to-pulmonary-fibrosis-in-an-experimental-model-of-paracoccidioidomycosis
#14
Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Julián Camilo Arango, Lina María Salazar-Peláez, Angel González
Itraconazole (ITC) is the drug of choice for treating paracoccidioidomycosis (PCM); nonetheless, patients with the chronic form of this mycosis develop fibrosis, a residual pulmonary abnormality, even after treatment. Recently, we observed that the depletion of neutrophils with a specific monoclonal antibody (mAb-anti-Ly6G) during the chronic stages of PCM was associated with a decrease in the fungal burden, the inflammatory response and a reduction of fibrosis. Herein, we aimed to evaluate the effect of ITC in combination with the mAb-anti-Ly6G in an experimental model of pulmonary PCM...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29412355/paracoccidioidomycosis-due-to-paracoccidioides-brasiliensis-s1-plus-hiv-co-infection
#15
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Rowena Alves Coelho, Hugo Boechat Andrade, Ana Beatriz Teixeira Brandão Camello Ferreira, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
BACKGROUND: Paracoccidioidomycosis (PCM) is one of the most important systemic mycoses in Latin America and the leading fungal cause of mortality in non-immunosuppressed individuals in Brazil. However, HIV/PCM co-infection can increase the clinical severity in these co-infected patients. This co-infection is rarely reported in the literature mainly because of the different epidemiological profiles of these infections. Furthermore, PCM is a neglected and non-notifiable disease, which may underestimate the real importance of this disease...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29409063/recovery-of-the-paracoccidioides-brasiliensis-virulence-after-animal-passage-promotes-changes-in-the-antioxidant-repertoire-of-the-fungus
#16
Daniele G Castilho, Marina V Navarro, Alison F A Chaves, Patricia Xander, Wagner L Batista
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM), a cause of disease in healthy and immunocompromised persons in Latin America. The infection begins after inhalation of the fungal propagules and their thermo-dimorphic shift to yeast form. The development of the disease depends on factors associated with the host immune response and the infectious agent's characteristics, especially virulence. The oxidative stress response is an important virulence attribute in several fungi. In this study, we assessed the enzymatic repertoire of responses to oxidative stress in the Pb18 isolate with different degrees of virulence...
February 2, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29405111/case-report-misleading-serological-diagnosis-of-paracoccidioidomycosis-in-a-young-patient-with-the-acute-form-disease-paracoccidioides-brasiliensis-or-paracoccidioides-lutzii
#17
Renata Buccheri, Vanessa Dos Santos Moraes, Camila Mika Kamikawa, Monica Scarpelli Martinelli Vidal, Gabriel Naves, Gilda Maria Barbaro Del Negro, Adriana Pardini Vicentini, Gil Benard
Negative results in serological routine screening of patients with microbiologically proven PCM are occasionally reported. Failure in detecting anti-Paracoccidioides antibodies has been ascribed to factors either related to serological techniques or to the status of the host immune reactivity. Recently, this issue has been renewed by the recognition that the Paracoccidioides genera comprises two species, lutzii and brasiliensis, which have distinct antigenic profiles and, therefore, may elicit different host antibody responses...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29361158/evaluation-of-caenorhabditis-elegans-as-a-host-model-for-paracoccidioides-brasiliensis-and-paracoccidioides-lutzii
#18
Liliana Scorzoni, Maria Pilar de Lucas, Junya de Lacorte Singulani, Haroldo Cesar de Oliveira, Patricia Akemi Assato, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini
Paracoccidioidomycosis is a systemic fungal infection affecting mainly Latin American countries that is caused by Paracoccidioides brasiliensis and Paracoccidioides lutzii. During the study of fungal pathogenesis, in vivo studies are crucial to understand the overall mechanisms involving the infection as well as to search for new therapeutic treatments and diagnosis. Caenorhabditis elegans is described as an infection model for different fungi species and a well-characterized organism to study the innate immune response...
February 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29346653/emergence-of-acute-subacute-infant-juvenile-paracoccidioidomycosis-in-northeast-argentina-effect-of-climatic-and-anthropogenic-changes
#19
Gustavo Giusiano, Clarisa Aguirre, Claudia Vratnica, Florencia Rojas, Teresa Corallo, María Emilia Cattana, Mariana Fernández, Javier Mussin, María de Los Angeles Sosa
Argentina has two endemic areas of paracoccidioidomycosis (PCM). Bordering Paraguay and Brazil, Northeast Argentina (NEA) comprises the area with the highest incidence where the chronic adult clinical form has historically been reported. Juvenile form in children and adolescents is rare in this area since only one case was reported in the last 10 years. Despite this, between 2010 and 2012, several cases of acute/subacute clinical forms in children aged 10 to 16 (median 12) were detected. In the last decade, the NEA region has been exposed to ecological variations as consequences of certain climatic and anthropogenic changes, including El Niño-Southern Oscillation phenomenon during 2009, and deforestation...
January 13, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29274088/autopsy-and-biopsy-study-of-paracoccidioidomycosis-and-neuroparacoccidioidomycosis-with-and-without-hiv-co-infection
#20
Sergio Monteiro de Almeida, Thiago Henrique Roza, Gabriel L O Salvador, Luís Felipe Izycki, Giuliana Locatelli, Isaias Dos Santos, Afonso Aragão, Luis Fernando Bleggi Torres, Lucia Helena de Noronha
Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent among immunocompetent patients in Latin America. This study aimed to describe the frequency, demographics and clinical characteristics of central nervous system PCM (NPCM) and PCM in an endemic region, and the impact of human immunosuppression virus (HIV) co-infection. This was a retrospective study of autopsy and biopsy reports from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil, between 1951 and 2014. PCM was present in 0...
April 2018: Mycoses
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