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Paracoccidioidomycosis

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https://www.readbyqxmd.com/read/29204222/paracoccidioidomycosis-current-perspectives-from-brazil
#1
REVIEW
Rinaldo Poncio Mendes, Ricardo de Souza Cavalcante, Sílvio Alencar Marques, Mariângela Esther Alencar Marques, James Venturini, Tatiane Fernanda Sylvestre, Anamaria Mello Miranda Paniago, Ana Carla Pereira, Julhiany de Fátima da Silva, Alexandre Todorovic Fabro, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli, Rosane Christine Hahn, Adriele Dandara Levorato
Background: This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis. Objectives: Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29187269/ophthalmic-paracoccidioidomycosis
#2
Juan Cataño, Alexander Salinas
No abstract text is available yet for this article.
December 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29181001/disease-tolerance-mediated-by-phosphorylated-indoleamine-2-3-dioxygenase-confers-resistance-to-a-primary-fungal-pathogen
#3
Eliseu Frank de Araújo, Flávio Vieira Loures, Cláudia Feriotti, Tania Costa, Carmine Vacca, Paolo Puccetti, Luigina Romani, Vera Lúcia Garcia Calich
Resistance to primary fungal pathogens is usually attributed to the proinflammatory mechanisms of immunity conferred by interferon-γ activation of phagocytes that control microbial growth, whereas susceptibility is attributed to anti-inflammatory responses that deactivate immunity. This study challenges this paradigm by demonstrating that resistance to a primary fungal pathogen such as Paracoccidiodes brasiliensis can be mediated by disease tolerance, a mechanism that preserves host fitness instead of pathogen clearance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#4
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29159660/opinion-paracoccidioidomycosis-and-hiv-immune-recovery-inflammatory-syndrome
#5
Renata Buccheri, Gil Benard
Two distinct patterns of immune recovery inflammatory syndrome (IRIS) are recognized, paradoxical and unmasking IRIS. Here we raise some concerns regarding the first case of neuroPCM-IRIS published to date, as recently proposed by Almeida and Roza (Mycopathologia 177:137-141, 2017) for a patient originally described by Silva-Vergara et al. (Mycopathologia 182:393-396, 2014), taking in account the different case definitions for IRIS and the cases of neuroparacoccidioidomycosis already described in the literature...
November 20, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29159027/a-case-of-paracoccidioidomycosis-due-to-paracoccidioides-lutzii-presenting-sarcoid-like-form
#6
Luiza Sarmento Tatagiba, Luana Bridi Pivatto, Álvaro A Faccini-Martínez, Paulo Mendes Peçanha, Tânia Regina Grão Velloso, Sarah Santos Gonçalves, Anderson Messias Rodrigues, Zoilo Pires Camargo, Aloísio Falqueto
Paracoccidioidomycosis (PCM) is a fungal disease caused by Paracoccidioides spp., which can cause a systemic granulomatous infection with tegumentary and visceral involvement. Sarcoid-like skin lesions are uncommon and can be misdiagnosed due to similarities with other granulomatous diseases. We report a case of a women presenting with erythematous infiltrated plaques on her face that was treated for leprosy and rosacea with no response and was later diagnosed with PCM, presenting positive serology for Paracoccidioides lutzii...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29153538/oral-paracoccidioidomycosis-in-a-single-center-retrospective-analysis-from-a-brazilian-southeastern-population
#7
Laís Moreira Dutra, Thiago Humberto Mendonça Silva, Aloísio Falqueto, Paulo Mendes Peçanha, Lucia Renata Meireles Souza, Sarah Santos Gonçalves, Tânia Regina Grão Velloso
BACKGROUND: Paracoccidioidomycosis (PCM) is the most prevalent endemic systemic fungal infection in Latin America. In Brazil, it stands out as the eighth-highest cause of mortality among chronic or recurrent infections and has the highest mortality rate among systemic mycoses. Oral mucosal lesions may be the first visible physical manifestation of the disease. This study traced the epidemiological and clinical profiles of patients with oral lesions treated at the University Hospital Cassiano Antonio Moraes, Federal University of Espirito Santo...
November 16, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29091134/increased-peripheral-blood-tcd4-counts-and-serum-sp-d-levels-in-patients-with-chronic-paracoccidioidomycosis-during-and-after-antifungal-therapy
#8
James Venturini, Ricardo Souza Cavalcante, Tatiane Fernanda Sylvestre, Rodolfo Ferreira Dos Santos, Daniela Vanessa Moris, Lídia Raquel Carvalho, Maria Sueli Parreira de Arruda, Marjorie de Assis Golim, Rinaldo Poncio Mendes
BACKGROUND: The main clinical forms of paracoccidioidomycosis (PCM) are the acute/subacute form (AF) and the chronic form (CF), and they both display considerable clinical variability. The immune responses of PCM patients, during and after treatment, remain neglected, mainly in the case of CF patients, due to the high prevalence of pulmonary sequelae. OBJECTIVE: To evaluate the distribution of whole blood T cell subsets, serum cytokines, and biomarkers of pulmonary fibrosis in PCM patients, according to the clinical form and at different time points, during the antifungal therapy...
November 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29071205/disseminated-paracoccidioidomycosis-prediagnosticated-as-neoplasm-an-important-challenge-in-diagnosis-using-rt-pcr
#9
Fabiana Rocha-Silva, Cássio Ferreira Guimarães, Edmundo Rocha de Oliveira Júnior, Sônia Maria de Figueiredo, Rachel Basques Caligiorne
This paper presents a case of disseminated paracoccidioidomycosis in a 62-year-old male patient, who lives in Belo Horizonte, MG, Brazil. The patient was hospitalized with icteric syndrome of cholestatic pattern and weight loss, with loss 30 kg in 5 months. The imaging of the abdomen showed lesion of infiltrative pattern, affecting gallbladder and intrahepatic bile ducts, suggesting neoplasia of malignant behavior, besides to presenting the yellow nail syndrome. Dermatological examination presented erythematous-infiltrated plaques in the occipital region...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29048286/paracoccidioidomycosis-after-highway-construction-rio-de-janeiro-brazil
#10
Antonio C Francesconi do Valle, Priscila Marques de Macedo, Rodrigo Almeida-Paes, Anselmo R Romão, Marcia Dos Santos Lazéra, Bodo Wanke
Transmission of Paracoccidioides spp. fungi to humans is usually related to manipulation of soil. Rural workers are the most affected group. We report an outbreak of paracoccidioidomycosis after deforestation and massive earth removal during construction of a highway in Rio de Janeiro, Brazil. Extensive environmental disturbances might be involved in fungal transmission.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29044299/erratum-brazilian-guidelines-for-the-clinical-management-of-paracoccidioidomycosis
#11
(no author information available yet)
[This corrects the article doi: 10.1590/0037-8682-0230-2017].
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29042530/hypereosinophilia-secondary-to-disseminated-paracoccidioidomycosis
#12
Mateo Mejia-Zuluaga, Samuel Rosas, Verónica Posada Vélez, Pedro A Quintero
BACKGROUND Paracoccidioidomycosis is an endemic mycosis in Central and South America caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. Despite its self-limited course and usually asymptomatic infection, some patients may present with a systemic illness mimicking multiple conditions and thus question the general state of their immune system. CASE REPORT A 28-year-old male presented to the hospital with fever, dry cough, and non-pruritic rash with no characteristic distribution for the past 10 days...
October 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29040281/impaired-anti-fibrotic-effect-of-bone-marrow-derived-mesenchymal-stem-cell-in-a-mouse-model-of-pulmonary-paracoccidioidomycosis
#13
Julián Camilo Arango, Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Lina María Salazar-Peláez, Mauricio Rojas, Ángel González
Bone marrow-derived mesenchymal stem cells (BMMSCs) have been consider as a promising therapy in fibrotic diseases. Experimental models suggest that BMMSCs may be used as an alternative therapy to treat chemical- or physical-induced pulmonary fibrosis. We investigated the anti-fibrotic potential of BMMSCs in an experimental model of lung fibrosis by infection with Paracoccidioides brasiliensis. BMMSCs were isolated and purified from BALB/c mice using standardized methods. BALB/c male mice were inoculated by intranasal infection of 1...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29029192/paracoccidioidomycosis-associated-with-a-heterozygous-stat4-mutation-and-impaired-ifn-%C3%AE-immunity
#14
Lena F Schimke, James Hibbard, Ruben Martinez-Barricarte, Taj Ali Khan, Ricardo de Souza Cavalcante, Edgar Borges de Oliveira Junior, Tabata Takahashi França, Asif Iqbal, Guilherme Yamamoto, Christina Arslanian, Claudia Feriotti, Tania Alves da Costa, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, José Alexandre Marzagao Barbuto, Mayana Zatz, Rinaldo Poncio Mendes, Vera Lucia Garcia Calich, Hans D Ochs, Troy R Torgerson, Otávio Cabral-Marques, Antonio Condino-Neto
Background: Mutations in genes affecting interferon (IFN)-γ immunity have contributed to understand the essential role of IFN-γ in the protection against intracellular pathogens. However, inborn errors in STAT4, which controls IL-12 responses, have not yet been reported. Objective: To determine the underlying genetic defect in a family with a history of paracoccidioidomycosis (PCM) disease. Methods: Genetic analysis was performed by whole-exome sequencing and sanger sequencing...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28992214/differential-production-of-interleukin-1-family-cytokines-il-1%C3%AE-il-18-il-33-and-il-37-in-patients-with-paracoccidioidomycosis-correlation-with-clinical-form-and-antifungal-therapy
#15
André Bueno Rocha Moreira Alves, Murilo Amato David, Lívia Furquim de Castro, Rosiane Maria da Silva, Larissa Nara Alegrini Longhi, Maria Heloisa de Souza Lima Blotta, Ronei Luciano Mamoni
Besides interleukin (IL)-1β and IL-18, the newly described cytokines of IL-1 family IL-33 and IL-37 can contribute to the differentiation and maintenance of different population of T cells. IL-33 acts as an allarmin and promotes a predominant Th2 inflammatory response, whereas IL-37 plays an important role as an antagonist of inflammation. In paracoccidioidomycosis (PCM), caused by the dimorphic fungi Paracoccidioides brasiliensis and P. lutzii, it has been shown that the acquired immune responses are associated with the diverse clinical manifestations...
July 28, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28970825/involvement-of-dihydrolipoyl-dehydrogenase-in-the-phagocytosis-and-killing-of-paracoccidioides-brasiliensis-by-macrophages
#16
Taise N Landgraf, Marcelo V Costa, Aline F Oliveira, Wander C Ribeiro, Ademilson Panunto-Castelo, Fabrício F Fernandes
Paracoccidioides brasiliensis and Paracoccidioides lutzii are fungi causing paracoccidioidomycosis (PCM), an autochthonous systemic mycosis found in Latin America. These microorganisms contain a multitude of molecules that may be associated with the complex interaction of the fungus with the host. Here, we identify the enzyme dihydrolipoyl dehydrogenase (DLD) as an exoantigen from P. brasiliensis (Pb18_Dld) by mass spectrometry. Interestingly, the DLD gene expression in yeast form showed higher expression levels than those in mycelial form and transitional phases...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28966914/laryngeal-paracoccidioidomycosis-presenting-as-solitary-true-vocal-fold-disease
#17
Walter de Araujo Eyer-Silva, Annelise Callmann Santana, Guilherme Almeida Rosa da Silva, Marcelo Costa Velho Mendes de Azevedo, Juliana Li Ting Matos Sun Barreto, Marina Apolloni Neumann, Izana Junqueira de Castro, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Nathane Zanineli Ré, Felipe Marques de Oliveira, Caio José de Araujo Simas, Marcos André de Sarvat, Fernando Raphael de Almeida Ferry
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis or P. lutzii. It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. We present the case of a 67-year-old Brazilian forest guard who presented with a 6-month history of hoarseness and globus pharyngeus due to a solitary left true vocal fold infiltration and vegetation diagnosed as PCM...
2017: IDCases
https://www.readbyqxmd.com/read/28954085/case-report-of-myeloperoxidase-deficiency-associated-with-disseminated-paracoccidioidomycosis-and-peritoneal-tuberculosis
#18
Maurício Domingues-Ferreira, Ariel Levy, Noac Chuffi Barros, Dalton Luis Bertolini, Dewton de Moraes Vasconcelos
Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28951317/therapeutic-treatment-with-scfv-plga-nanoparticles-decreases-pulmonary-fungal-load-in-a-murine-model-of-paracoccidioidomycosis
#19
Grasielle Pereira Jannuzzi, Nicole de Araújo Souza, Kátia Sanches Françoso, Roney Henrique Pereira, Raquel Possemozer Santos, Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Wagner Luiz Batista, André Corrêa Amaral, Andrea Queiroz Maranhão, Sandro Rogério de Almeida, Karen Spadari Ferreira
Paracoccidioidomycosis (PCM) is a systemic mycosis with lymphatic dissemination that is caused by Paracoccidioides species. Treatment of PCM consists of chemotherapeutics such as itraconazole, trimethoprim, sulfamethoxazole or amphotericin B. However, several studies are aiming to develop therapeutic alternatives for the treatment of fungal infection using new molecules as adjuvants. The single-chain variable fragments (scFv) from an antibody that mimics the main fungal component incorporated within poly(lactide-co-glycolic) acid (PLGA) nanoparticles helped treat the fungal disease...
September 23, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28938005/recombinant-vaccines-of-a-cd4-t-cell-epitope-promote-efficient-control-of-paracoccidioides-brasiliensis-burden-by-restraining-primary-organ-infection
#20
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived particle (VLP) as an antigen carrier. This chimera was administered to mice as a (His)6-purified protein (rPbT) or a replication-deficient human type 5 adenoviral vector (rAdPbT) in an immunoprophylaxis assay...
September 2017: PLoS Neglected Tropical Diseases
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