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Paracoccidioidomycosis

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https://www.readbyqxmd.com/read/28646277/standardization-and-prevalence-of-the-booster-phenomenon-evaluation-using-a-two-step-skin-test-with-43%C3%A2-kda-glycoprotein-in-individuals-from-an-endemic-region-of-paracoccidioidomycosis
#1
Ana Paula C Marques, Sandra Maria V L Oliveira, Grazielli R Rezende, Dayane A Melo, Sonia M Fernandes-Fitts, Elenir Rose J C Pontes, Maria da Glória Bonecini-Almeida, Zoilo P Camargo, Rinaldo P Mendes, Anamaria M M Paniago
BACKGROUND: We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. METHODS: Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon...
June 23, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28637229/can-passage-in-galleria-mellonella-activate-virulence-factors-of-paracoccidioides-brasiliensis-as-in-the-murine-model
#2
Liliana Scorzoni, Ana Carolina Alves de Paula E Silva, Haroldo Cesar de Oliveira, Caroline Maria Marcos, Junya de Lacorte Singulani, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini
Paracoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioides spp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P...
June 15, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28606816/altered-distribution-of-peripheral-blood-dendritic-cell-subsets-in-patients-with-pulmonary-paracoccidioidomycosis
#3
James Venturini, Ricardo Souza Cavalcante, Daniela Vanessa Moris, Márjorie de Assis Golim, Adriele Dandara Levorato, Karoline Hagatha Dos Reis, Maria Sueli Parreira de Arruda, Rinaldo Poncio Mendes
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi from the genus Paracoccidioides in Latin America. PCM-patients (PCM-p) are classified as having acute/subacute or chronic (CF) clinical forms. CF is responsible for 75% - 90% of all cases, affects mainly adults over 30 years old and the clinical manifestation are associated mainly with lungs and mucosa of upper airdigestive tract. In addition, the CF patients exhibit fibrosis of the lungs, oral mucous membranes and adrenals, and pulmonary emphysema...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28600728/the-critical-role-of-notch1-tlr-4-signaling-in-the-inflammatory-and-fungicidal-activity-of-macrophages-against-paracoccidioides-brasiliensis-strain-pb18
#4
Lavínia Maria Dal'Mas Romera, Gilberto Hideo Kaihami, Grasielle Pereira Jannuzzi, José Roberto Fogaça de Almeida, Sandro Rogério de Almeida
Paracoccidioidomycosis is a systemic mycosis of deep nature that primarily affects the lung and can spread via lymphatic and hematogenous to other organs and tissues. It is mainly caused by Paracoccidioides brasiliensis fungus which exhibits thermal dimorphism. The innate immune system mediated by macrophages is extremely important for the control of infection and is involved in the induction and regulation of immune/inflammatory response. These cells are able to recognize pathogens through pattern recognition receptors (PRRs) such as Toll-like receptors (TLR)...
June 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28591264/sarcoid-like-cutaneous-lesions-in-chronic-adult-paracoccidioidomycosis-report-of-two-cases
#5
Nurimar C Fernandes, Júlia Gomes Côrtes, Tiyomi Akitti, Danielle Carvalho Quintella, Tulia Cuzzi
This study reports two cases of chronic paracoccidioidomycosis with sarcoid-like cutaneous lesions. The patients began the treatment in 2013 at Hospital Universitário Clementino Fraga Filho (HUCFF) of the Universidade Federal do Rio de Janeiro (UFRJ). The first case (mild form) was treated with trimethoprim-sulfamethoxazole (8 mg /kg per day, orally) for three months and, then, with half the dose for nine months; the second (moderate form), with itraconazole (200 mg per day, orally) for 12 months. We point out the rareness of the sarcoid-like cutaneous lesions and the differential diagnoses for other granulomatous diseases...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28584992/yeast-expressing-gp43-protein-as-a-vaccine-against-paracoccidioides-brasiliensis-infection
#6
Aline Ferreira Oliveira, Paulo S R Coelho
Paracoccidioidomycosis (PCM) represents the most frequent systemic mycosis in Latin American. The disease is caused by the pathogenic thermally dimorphic fungus Paracoccidioides brasiliensis, and is initially characterized by pulmonary lesions, which can subsequently disseminate to other organs, resulting in secondary injuries. Although its high incidence, there is no commercially available vaccine against fungal diseases. A novel strategy, using Saccharomyces cerevisiae yeast as a vehicle for immunization against PCM, was recently successfully described...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28584990/th1-inducing-agents-in-prophylaxis-and-therapy-for-paracoccidioidomycosis
#7
Thiago Aparecido da Silva, Fabrício Freitas Fernandes, Taise Natali Landgraf, Ademílson Panunto-Castelo, Maria Cristina Roque-Barreira
Adjuvants and immunomodulatory molecules could be included in the treatment of P. brasiliensis infection. In this context, we reported that the therapeutic and/or prophylactic administration of Th1-inducing agents, such as immunomodulatory lectins and adjuvants, was able to provide protection against experimental paracoccidioidomycosis. Then, we described the protocols to investigate the effect of immunomodulatory agents on the course of P. brasiliensis infection. In this sense, we detailed the measurement of fungal burden and cytokine production, and the histopathological analysis used to evaluate the most effective administration regime...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28584987/peptide-vaccine-against-paracoccidioidomycosis
#8
Carlos P Taborda, Luiz R Travassos
The chapter reviews methods utilized for the isolation and characterization of a promising immunogen candidate, aiming at a human vaccine against paracoccidioidomycosis. Peptide P10 carries a T-CD4+ epitope and was identified as an internal sequence of the major diagnostic antigen known as gp43 glycoprotein. It successfully treated massive intratracheal infections by virulent Paracoccidioides brasiliensis in combination with chemotherapy.An introduction about the systemic mycosis was found essential to understand the various options that were considered to design prophylactic and therapeutic vaccine protocols using peptide P10...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28584985/dnahsp65-vaccine-as-therapy-against-paracoccidioidomycosis
#9
Alice M Ribeiro, André C Amaral, Maria Sueli S Felipe, Anamelia L Bocca
The conventional treatment for fungal diseases usually shows long periods of therapy and the high frequency of relapses and sequels. New strategies of the treatment are necessary. We have shown that the Mycobacterium leprae HSP65 gene can be successfully used as therapy against murine Paracoccidioidomycosis (PCM). Here, we described the methodology of DNAhsp65 immunotherapy in mice infected with the dimorphic fungus Paracoccidioides brasiliensis, one of PCM agent, evaluating cytokines levels, fungal burden, and lung injury...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28584979/mouse-immunization-with-radioattenuated-yeast-cells-of-paracoccidioides-brasiliensis
#10
Estefânia Mara do Nascimento Martins, Antero Silva Ribeiro de Andrade
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis, the most prevalent mycosis in Latin America, and currently there is no effective vaccine. The present chapter describes the methodology to obtain radioattenuated yeast cells of P. brasiliensis and a protocol to evaluate protective response elicited by this immunogen in experimental paracoccidioidomycosis. The radioattenuated yeast provides a valuable tool for immunological studies in experimental paracoccidioidomycosis and vaccine research...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28584679/pseudotumoral-neuroparacoccidioidomycosis-of-the-posterior-fossa-a-case-report-and-review-of-the-literature
#11
Luiz Antonio Jorge, Seizo Yamashita, André Petean Trindade, Luiz Antonio Lima Resende, Marco Antonio Zanini, José Cândido Caldeira Xavier, Marcelo Padovani de Toledo Moraes
BACKGROUND: Paracoccidioidomycosis is a systemic mycosis of significant importance in some Latin American countries. The widespread use of neuroimaging methods has shown that involvement of the central nervous system was more frequent than previously reported. The most common form of occurrence of neuroparacoccidioidomycosis is the pseudotumoral one. The authors report a case of pseudotumoral neuroparacoccidioidomycosis localized in the posterior fossa. CASE DESCRIPTION: A 49-year-old single man, rural worker, born and raised in Laranjal Paulista-SP, was admitted to the hospital with 3 months history of bilateral occipital headache every day...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28583268/voice-disorders-in-residual-paracoccidioidomycosis-in-upper-airways-and-digestive-tract
#12
Ananda Dutra da Costa, Amanda Pereira Vargas, Marcia Mendonça Lucena, Ana Cristina Nunes Ruas, Fernanda da Silva Santos Braga, Mateus Pereira Bom-Braga, Frederico Pereira Bom-Braga, Antonio Carlos Francesconi do Valle, Ricardo Pereira Igreja, Cláudia Maria Valete-Rosalino
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis of acute and chronic evolution, caused by species belonging to the genus Paracoccidioides. It is considered the most prevalent systemic endemic mycosis in Latin America, with cases in the tropical and subtropical regions. Residual PCM refers to the fibrotic scar sequelae resulting from the disease treatment which, when associated with collagen accumulation, leads to functional and anatomic alterations in the organs. AIMS: The aim of this study was to evaluate the vocal function of patients with residual PCM in upper airways and digestive tract...
June 2, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28577123/hepatic-disease-with-portal-hypertension-and-acute-juvenile-paracoccidioidomycosis-a-report-of-two-cases-and-literature-review
#13
REVIEW
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Dayvison Francis Saraiva Freitas, Fabio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, João Carlos de Almeida Soares, Andrea D'Ávila Freitas, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
Paracoccidioidomycosis (PCM) is a neglected systemic mycosis endemic to Latin America caused by dimorphic fungi of the genus Paracoccidioides. The acute juvenile PCM is a severe type of presentation that usually affects young vulnerable patients and rarely progresses to portal hypertension. Here, two cases of liver disease and portal hypertension as complications of acute juvenile PCM are reported. Diagnosis of PCM was performed by isolation of the fungus and molecular identification of the strains provided through partial sequencing of two protein encoding genes, arf and gp43...
June 2, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28562770/paracoccidioidomycosis-with-sarcoid-like-lesions-a-diagnostic-challenge
#14
Marilda Aparecida Milanez Morgado de Abreu, Joel Carlos Lastória, Antonio Luiz de Arruda Mattos, Maurício Mota de Avelar Alchorne
Clinical presentation of paracoccidioidomycosis (PCM) can be diverse. Morphology and quantity of skin lesions depends on interactions between host immunity and fungus virulence. Diagnosis can be a challenge considering that this fungus has low virulence and some individuals have immunity to microorganism, which results in well-marked granulomas without visible microorganisms. We report herein a clinical presentation of sarcoid-like PCM, initially diagnosed as tuberculoid leprosy. This rare type of PCM is often mistaken for other types of chronic granulomatous diseases...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28553014/paracoccidioides-spp-virulence-factors-and-immune-evasion-strategies
#15
REVIEW
Emma Camacho, Gustavo A Niño-Vega
Paracoccidioides spp. are dimorphic fungal pathogens responsible for one of the most relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact ecological niche remains unknown; however, they have been isolated from soil samples and armadillos (Dasypus novemcinctus), which have been proposed as animal reservoir for these fungi. Human infection occurs by inhalation of conidia or mycelia fragments and is mostly associated with immunocompetent hosts inhabiting and/or working in endemic rural areas...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28547342/trichosporon-asteroides-isolated-from-cutaneous-lesions-of-a-suspected-case-of-paracoccidioidomycosis-ceti-in-a-bottlenose-dolphin-tursiops-truncatus
#16
Keiichi Ueda, Ichiro Nakamura, Eiko Nakagawa Itano, Kazunori Takemura, Yasutomo Nakazato, Ayako Sano
"Paracoccidioidomycosis ceti" is a rare zoonotic fungal infection affecting dolphins and is endemic worldwide. The causative agents are Paracoccidioides species; however, it is impossible to isolate the fungal species. We isolated Trichosporon asteroides from multifocal, irregularly raised skin lesions on a female bottlenose dolphin (Tursiops truncatus) captured off coast of Japan, which was suspected to have "paracoccidioidomycosis ceti." An abundance of round, yeast-like cells was detected in a potassium hydroxide direct-mount specimen of the skin samples; however, nested PCR targeting the partial sequence of 43-kDa glycoprotein-coding gene correspondent to Paracoccidioides sp...
May 25, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28545968/molecular-cloning-expression-and-insulin-reduction-activity-of-a-thioredoxin-1-homologue-trx1-from-the-pathogenic-fungus-paracoccidioides-lutzii
#17
Lorena C Cintra, Fernanda C Domingos, Yanna A R Lima, Mônica S Barbosa, Rodrigo S Santos, Fabrícia P Faria, Rosália S A Jesuíno
The dimorphic fungi Paracoccidioides spp. are the etiological agents of paracoccidioidomycosis (PCM), a prevalent systemic mycosis in Latin America. The Paracoccidioides lutzii response to oxidative stress is largely unexplored. Thioredoxins (TRX) are involved in the regulation of the redox environment in the cell, responding to oxidative stress in several organisms. In this study, we describe the isolation and characterization of a cDNA encoding a thioredoxin 1 from yeast cells from P. lutzii. The cDNA codes for a 12kDa protein containing the characteristic thioredoxin active site...
May 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28541872/chronic-paracoccidioidmycosis-in-a-woman-with-crohn-disease
#18
Harim Tavares Dos Santos, Bruno Augusto Benevenuto de Andrade, Darcy Fernandes, Daphine Caxias Travassos, Andreia Bufalino
We report a rare case of chronic paracoccidioidomycosis(PCM) in a woman with Crohn disease in the setting of treatment with azathioprine and mesalazine. Serum tests for antigens to Paracoccidioides brasiliensis, Histoplasma capsulatum, and Aspergillus fumigatus were negative. An incisional biopsy of an oral lesion with periodic acid-schiff and Grocott-methenamine silver stains revealed chronic granulomatous inflammation with multinucleated giant cells with Paracoccidioides brasiliensis within the cytoplasm, confirming the diagnosis of PCM...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28523421/serological-evidence-of-infection-by-paracoccidioides-brasiliensis-in-dogs-with-leishmaniasis
#19
Tatiane Ferreira Petroni, Lucas Xavier Bonfietti, Tiago Henrique Zaninelli, Eiko Nakagawa Itano, Mario Augusto Ono
Paracoccidioidomycosis is a systemic mycosis prevalent in Latin American countries, caused by the dimorphic fungi Paracoccidioides brasiliensis and P. lutzii. The habitat of these fungi in nature remains undefined, although it is believed that infection occurs by inhalation of infective propagules present in soil. Sentinel animals, such as dogs, can be valuable epidemiological markers of paracoccidioidomycosis. Taking into account that paracoccidioidomycosis and visceral leishmaniasis may occur in the same area, the objective of this study was to evaluate the occurrence of P...
May 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28500805/unusual-otolaryngologic-manifestations-of-paracoccidioidomycosis-a-case-report-and-review-of-literature
#20
Lucas Resende Lucinda, José Fernando Polanski
AbstractParacoccidioidomycosis is a systemic mycosis caused by Paracoccidioides brasiliensis. It occurs more frequently in its chronic form, which particularly affects male adults from rural areas. These patients present with pulmonary involvement and systemic symptoms. Skin and mucosal lesions are rather typical and might suggest the diagnosis. The involvement of the upper airway mucosa is common and the patients usually complain of dysphagia and dysphonia. Nonetheless, in endemic areas, physicians should maintain a high level of suspicion even when faced with some atypical symptoms...
May 2017: American Journal of Tropical Medicine and Hygiene
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