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Paracoccidioidomycosis

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https://www.readbyqxmd.com/read/29040281/impaired-anti-fibrotic-effect-of-bone-marrow-derived-mesenchymal-stem-cell-in-a-mouse-model-of-pulmonary-paracoccidioidomycosis
#1
Julián Camilo Arango, Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Lina María Salazar-Peláez, Mauricio Rojas, Ángel González
Bone marrow-derived mesenchymal stem cells (BMMSCs) have been consider as a promising therapy in fibrotic diseases. Experimental models suggest that BMMSCs may be used as an alternative therapy to treat chemical- or physical-induced pulmonary fibrosis. We investigated the anti-fibrotic potential of BMMSCs in an experimental model of lung fibrosis by infection with Paracoccidioides brasiliensis. BMMSCs were isolated and purified from BALB/c mice using standardized methods. BALB/c male mice were inoculated by intranasal infection of 1...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29029192/paracoccidioidomycosis-associated-with-a-heterozygous-stat4-mutation-and-impaired-ifn-%C3%AE-immunity
#2
Lena F Schimke, James Hibbard, Ruben Martinez-Barricarte, Taj Ali Khan, Ricardo de Souza Cavalcante, Edgar Borges de Oliveira Junior, Tabata Takahashi França, Asif Iqbal, Guilherme Yamamoto, Christina Arslanian, Claudia Feriotti, Tania Alves da Costa, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, José Alexandre Marzagao Barbuto, Mayana Zatz, Rinaldo Poncio Mendes, Vera Lucia Garcia Calich, Hans D Ochs, Troy R Torgerson, Otávio Cabral-Marques, Antonio Condino-Neto
Background: Mutations in genes affecting interferon (IFN)-γ immunity have contributed to understand the essential role of IFN-γ in the protection against intracellular pathogens. However, inborn errors in STAT4, which controls IL-12 responses, have not yet been reported. Objective: To determine the underlying genetic defect in a family with a history of paracoccidioidomycosis (PCM) disease. Methods: Genetic analysis was performed by whole-exome sequencing and sanger sequencing...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28992214/differential-production-of-interleukin-1-family-cytokines-il-1%C3%AE-il-18-il-33-and-il-37-in-patients-with-paracoccidioidomycosis-correlation-with-clinical-form-and-antifungal-therapy
#3
André Bueno Rocha Moreira Alves, Murilo Amato David, Lívia Furquim de Castro, Rosiane Maria da Silva, Larissa Nara Alegrini Longhi, Maria Heloisa de Souza Lima Blotta, Ronei Luciano Mamoni
Besides interleukin (IL)-1β and IL-18, the newly described cytokines of IL-1 family IL-33 and IL-37 can contribute to the differentiation and maintenance of different population of T cells. IL-33 acts as an allarmin and promotes a predominant Th2 inflammatory response, whereas IL-37 plays an important role as an antagonist of inflammation. In paracoccidioidomycosis (PCM), caused by the dimorphic fungi Paracoccidioides brasiliensis and P. lutzii, it has been shown that the acquired immune responses are associated with the diverse clinical manifestations...
July 28, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28970825/involvement-of-dihydrolipoyl-dehydrogenase-in-the-phagocytosis-and-killing-of-paracoccidioides-brasiliensis-by-macrophages
#4
Taise N Landgraf, Marcelo V Costa, Aline F Oliveira, Wander C Ribeiro, Ademilson Panunto-Castelo, Fabrício F Fernandes
Paracoccidioides brasiliensis and Paracoccidioides lutzii are fungi causing paracoccidioidomycosis (PCM), an autochthonous systemic mycosis found in Latin America. These microorganisms contain a multitude of molecules that may be associated with the complex interaction of the fungus with the host. Here, we identify the enzyme dihydrolipoyl dehydrogenase (DLD) as an exoantigen from P. brasiliensis (Pb18_Dld) by mass spectrometry. Interestingly, the DLD gene expression in yeast form showed higher expression levels than those in mycelial form and transitional phases...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28966914/laryngeal-paracoccidioidomycosis-presenting-as-solitary-true-vocal-fold-disease
#5
Walter de Araujo Eyer-Silva, Annelise Callmann Santana, Guilherme Almeida Rosa da Silva, Marcelo Costa Velho Mendes de Azevedo, Juliana Li Ting Matos Sun Barreto, Marina Apolloni Neumann, Izana Junqueira de Castro, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Nathane Zanineli Ré, Felipe Marques de Oliveira, Caio José de Araujo Simas, Marcos André de Sarvat, Fernando Raphael de Almeida Ferry
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis or P. lutzii. It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. We present the case of a 67-year-old Brazilian forest guard who presented with a 6-month history of hoarseness and globus pharyngeus due to a solitary left true vocal fold infiltration and vegetation diagnosed as PCM...
2017: IDCases
https://www.readbyqxmd.com/read/28954085/case-report-of-myeloperoxidase-deficiency-associated-with-disseminated-paracoccidioidomycosis-and-peritoneal-tuberculosis
#6
Maurício Domingues-Ferreira, Ariel Levy, Noac Chuffi Barros, Dalton Luis Bertolini, Dewton de Moraes Vasconcelos
Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28951317/therapeutic-treatment-with-scfv-plga-nanoparticles-decreases-pulmonary-fungal-load-in-a-murine-model-of-paracoccidioidomycosis
#7
Grasielle Pereira Jannuzzi, Nicole de Araújo Souza, Kátia Sanches Françoso, Roney Henrique Pereira, Raquel Possemozer Santos, Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Wagner Luiz Batista, André Corrêa Amaral, Andrea Queiroz Maranhão, Sandro Rogério de Almeida, Karen Spadari Ferreira
Paracoccidioidomycosis (PCM) is a systemic mycosis with lymphatic dissemination that is caused by Paracoccidioides species. Treatment of PCM consists of chemotherapeutics such as itraconazole, trimethoprim, sulfamethoxazole or amphotericin B. However, several studies are aiming to develop therapeutic alternatives for the treatment of fungal infection using new molecules as adjuvants. The single-chain variable fragments (scFv) from an antibody that mimics the main fungal component incorporated within poly(lactide-co-glycolic) acid (PLGA) nanoparticles helped treat the fungal disease...
September 23, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28938005/recombinant-vaccines-of-a-cd4-t-cell-epitope-promote-efficient-control-of-paracoccidioides-brasiliensis-burden-by-restraining-primary-organ-infection
#8
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived particle (VLP) as an antigen carrier. This chimera was administered to mice as a (His)6-purified protein (rPbT) or a replication-deficient human type 5 adenoviral vector (rAdPbT) in an immunoprophylaxis assay...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28903987/heat-shock-proteins-in-histoplasma-and-paracoccidioides-a-minireview
#9
Levi G Cleare, Daniel Zamith Miranda, Joshua D Nosanchuk
Heat shock proteins (hsps) are highly conserved biomolecules that are constitutively expressed and generally up-regulated in response to various stress conditions (biotic and abiotic). Hsps have diverse functions, categorizations, and classifications. Their adaptive expression in fungi indicates their significance in these diverse species, particularly in dimorphic pathogens. Histoplasma capsulatum, and Paracoccidioides species pluralis are dimorphic fungi that are the causative agents of histoplasmosis and paracoccidioidomycosis, respectively...
September 13, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28900882/acute-paracoccidioidomycosis-in-a-40-year-old-man-a-case-report-and-literature-review
#10
Lucas Ferreira Rocha, Danielle de Araújo Torres
Paracoccidioidomycosis (PCM) is a systemic mycosis that represents an important public health problem in Latin America due to its life-threatening character. It is considered occupational disease of agricultural workers. In this report, we present a rare and serious case of the acute form of the disease in a 40-year-old man with no history of contact with the rural environment. Diagnosis was made through cervical lymph node biopsy, and treatment was performed with antifungal drugs, which produced effective results...
September 12, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28895099/neurological-and-multiple-organ-involvement-due-to-paracoccidioides-brasiliensis-and-hiv-co-infection-diagnosed-at-autopsy
#11
Sergio Monteiro de Almeida, Thiago H Roza, Gabriel L O Salvador, João C B França, Luine Rosele Renaud Vidal, Meri Bordignon Nogueira, Lubomira Veronica Oliva, Luis Fernando Bleggi Torres, Lucia Helena de Noronha
Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent systemic mycosis among immunocompetent patients in Latin America; it is rare in immunocompromised patients. The estimated frequency of central nervous system (CNS) involvement in the HIV/PCM population was 2.5%. We report a case of HIV/P. brasiliensis co-infection, with neurological (NPCM) and multiple organ involvement, indicating a diagnosis of AIDS. PCM diagnosis was established during the autopsy. This is the first described case of HIV/P...
September 11, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28881447/combination-of-histopathology-and-ft-raman-spectroscopy-for-the-study-of-experimental-paracoccidiodomycosis-pcm-in-the-spleen
#12
Elaine Sciuniti Benites Mansano, Gutierrez Rodriguês de Morais, Edilaine Martins Moratto, Francielle Sato, Mauro Luciano Baesso, Antonio Neto Medina, Terezinha Inez Estivalet Svidzinski, Luzmarina Hernandes
Paracoccidioides brasiliensis (Pb) can disseminate through the lymphatic and hematogenic pathways. As a result the spleen and other lymphoid organs are targets of paracoccidioidomycosis. There are few studies describing this disease in the spleen and more detailed descriptions are required. The present study combines Histopathology and Fourier Transform Raman Spectroscopy (FT-Raman) methods to study spleen infected by Pb. The Swiss mice were euthanized after one, two, four and eight weeks of infection with Pb and their spleens were removed for ex vivo analyzes...
September 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28871251/th17-inducing-cytokines-il-6-and-il-23-are-crucial-for-granuloma-formation-during-experimental-paracoccidioidomycosis
#13
Fabrine Sales Massafera Tristão, Fernanda Agostini Rocha, Daniela Carlos, Natália Ketelut-Carneiro, Camila Oliveira Silva Souza, Cristiane Maria Milanezi, João Santana Silva
Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis. The T helper 1-mediated immunity is primarily responsible for acquired resistance during P. brasiliensis infection, while susceptibility is associated with Th2 occurrence. Th17 is a population of T CD4(+) cells that, among several chemokines and cytokines, produces IL-17A and requires the presence of IL-1, IL-6, and TGF-β for differentiation in mice and IL-23 for its maintenance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28844734/employing-proteomic-analysis-to-compare-paracoccidioides-lutzii-yeast-and-mycelium-cell-wall-proteins
#14
Danielle Silva Araújo, Patrícia de Sousa Lima, Lilian Cristiane Baeza, Ana Flávia Alves Parente, Alexandre Melo Bailão, Clayton Luiz Borges, Célia Maria de Almeida Soares
Paracoccidioidomycosis is an important systemic mycosis caused by thermodimorphic fungi of the Paracoccidioides genus. During the infective process, the cell wall acts at the interface between the fungus and the host. In this way, the cell wall has a key role in growth, environment sensing and interaction, as well as morphogenesis of the fungus. Since the cell wall is absent in mammals, it may present molecules that are described as target sites for new antifungal drugs. Despite its importance, up to now few studies have been conducted employing proteomics in for the identification of cell wall proteins in Paracoccidioides spp...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28811998/paracoccidioidomycosis-level-of-pulmonary-sequelae-in-high-resolution-computed-tomography-images-from-patients-of-two-endemic-regions-of-brazil
#15
Diana Rodrigues de Pina, Matheus Alvarez, Guilherme Giacomini, Ana Luiza Menegatti Pavan, Carlos Ivan Andrade Guedes, Ricardo de Souza Cavalcante, Rinaldo Poncio Mendes, Anamaria Mello Miranda Paniago
BACKGROUND: The purpose of the present study was to evaluate differences in lung damage in patients with paracoccidioidomycosis (PCM) in two endemic regions of Brazil (Botucatu, SP, in the southeastern region and Campo Grande, MS, in the west central region). METHODS: The study sought to objectively quantify fibrosis and emphysema treated patients using high-resolution computed tomography (HRCT) that was performed according to an established and validated computational method...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28796894/subtractive-phage-display-selection-for-screening-and-identification-of-peptide-sequences-with-potential-use-in-serodiagnosis-of-paracoccidioidomycosis-caused-by-paracoccidioides-brasiliensis
#16
L da Silva Portes, E S Kioshima, Z P de Camargo, W L Batista, P Xander
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease endemic in Latin America whose aetiologic agents are the thermodimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii. Despite technological advances, some problems have been reported for the fungal antigens used for serological diagnosis, and inconsistencies among laboratories have been reported. The use of synthetic peptides in the serological diagnosis of infectious diseases has proved to be a valuable strategy because in some cases, the reactions are more specific and sensitive...
August 10, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28791025/the-ido-ahr-axis-controls-th17-treg-immunity-in-a-pulmonary-model-of-fungal-infection
#17
Eliseu Frank de Araújo, Claudia Feriotti, Nayane Alves de Lima Galdino, Nycolas Willian Preite, Vera Lúcia Garcia Calich, Flávio Vieira Loures
In infectious diseases, the enzyme indoleamine 2,3 dioxygenase-1 (IDO1) that catalyzes the tryptophan (Trp) degradation along the kynurenines (Kyn) pathway has two main functions, the control of pathogen growth by reducing available Trp and immune regulation mediated by the Kyn-mediated expansion of regulatory T (Treg) cells via aryl hydrocarbon receptor (AhR). In pulmonary paracoccidioidomycosis (PCM) caused by the dimorphic fungus Paracoccidioides brasiliensis, IDO1 was shown to control the disease severity of both resistant and susceptible mice to the infection; however, only in resistant mice, IDO1 is induced by TGF-β signaling that confers a stable tolerogenic phenotype to dendritic cells (DCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28774696/neglected-endemic-mycoses
#18
REVIEW
Flavio Queiroz-Telles, Ahmed Hassan Fahal, Diego R Falci, Diego H Caceres, Tom Chiller, Alessandro C Pasqualotto
Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Most of these diseases have a subacute to chronic course and they can become recalcitrant to therapy and lead to physical disabilities, including inability to work, physical deformities, and amputations...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28749757/paracoccidioidomycosis-epidemiological-and-clinical-aspects-in-546-cases-studied-in-the-state-of-esp%C3%A3-rito-santo-brazil
#19
Paulo Mendes Peçanha, Mayara Elisa Batista Ferreira, Maria Angélica Massaroni Peçanha, Edilaine Brandão Schmidt, Mariceli Lamas de Araújo, Raphael Lubiana Zanotti, Felipe Fonseca Potratz, Nilo Eduardo Delboni Nunes, Carlos Urbano Gonçalves Ferreira, Délio Delmaestro, Aloísio Falqueto
Paracoccidioidomycosis (PCM) is an endemic disease in the southeast region of Brazil, which includes the state of Espírito Santo (ES). This historic case series analyses 546 patients treated in this state from 1978 to 2012. Patients aged from 7 to 83 years, 509 males and 37 females, yielding a ratio of 13.7:1. Most of the patients (81.4%) originated from rural areas in ES, 71.0% being farmers. A higher concentration of cases was observed in municipalities located along the western range of the state. Sixty patients (11...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28746570/brazilian-guidelines-for-the-clinical-management-of-paracoccidioidomycosis
#20
Maria Aparecida Shikanai-Yasuda, Rinaldo Pôncio Mendes, Arnaldo Lopes Colombo, Flávio de Queiroz-Telles, Adriana Satie Gonçalves Kono, Ana Maria Paniago, André Nathan, Antonio Carlos Francisconi do Valle, Eduardo Bagagli, Gil Benard, Marcelo Simão Ferreira, Marcus de Melo Teixeira, Mario León Silva-Vergara, Ricardo Mendes Pereira, Ricardo de Souza Cavalcante, Rosane Hahn, Rui Rafael Durlacher, Zarifa Khoury, Zoilo Pires de Camargo, Maria Luiza Moretti, Roberto Martinez
Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P...
July 20, 2017: Revista da Sociedade Brasileira de Medicina Tropical
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