keyword
MENU ▼
Read by QxMD icon Read
search

Psoriasis quality of life

keyword
https://www.readbyqxmd.com/read/29658378/improvement-of-depressive-symptoms-in-patients-with-moderate-to-severe-psoriasis-treated-with-ustekinumab-an-open-label-trial-validated-using-beck-depression-inventory-hamilton-depression-rating-scale-measures-and-18-fluorodeoxyglucose-fdg-positron-emission
#1
Seong-Jang Kim, Min-Young Park, Kyoungjune Pak, Junhee Han, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Psoriasis is a chronic skin disease associated with psychiatric co-morbidities, especially depression. Early detection of psychological vulnerability in patients with psoriasis seems to be of great clinical importance and significantly impacts the quality of life of the patients. OBJECTIVES: We sought to clarify the association between psoriasis and depressive symptoms in patients with moderate to severe psoriasis, and to determine the risk factors for depressive symptoms and analyse the effect of ustekinumab on the symptoms...
April 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29653208/efficacy-and-safety-of-ixekizumab-over-4-years-of-open-label-treatment-in-a-phase-2-study-in-chronic-plaque-psoriasis
#2
Claus Zachariae, Kenneth Gordon, Alexandra Kimball, Mark Lebwohl, Andrew Blauvelt, Craig Leonardi, Daniel Braun, Missy McKean-Matthews, Russel Burge, Gregory Cameron
BACKGROUND: Ixekizumab has demonstrated improvement in moderate-to-severe psoriasis patients by selectively targeting interleukin-17A, a pro-inflammatory cytokine important in psoriasis pathogenesis. OBJECTIVE: To report 4-year efficacy and safety results from the open-label extension (OLE) of this phase 2 trial. METHODS: Analysis was by last observation carried forward. Patients received ixekizumab 120 mg then 80 mg subcutaneously once every 4 weeks...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29648989/analysis-of-sexual-problems-in-men-with-psoriasis
#3
Marta Wojciechowska-Zdrojowy, Adam Reich, Jacek C Szepietowski, Adam Wojciechowski
INTRODUCTION: Psoriasis may have negative impact on many aspects of patient life. OBJECTIVE: The aim of the study was to evaluate the influence of psoriasis on erectile dysfunction and other sexual problems in men with psoriasis. MATERIALS AND METHODS: A total of 76 men aged between 20 and 66 years (mean 43.9±13.2 years) were enrolled. Psoriasis severity assessed according to PASI ranged from 2.0 to 49.8 points (mean 15.1±10.3 points). All patients were asked to complete International Index of Erectile Function (IIEF-5), Beck's Depression Inventory and Dermatology Life Quality Index...
April 12, 2018: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29644193/nonvenereal-penile-dermatoses-a-retrospective-study
#4
Ana Marcos-Pinto, Luís Soares-de-Almeida, João Borges-Costa
Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis. Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Materials and Methods: A retrospective study was conducted. We reviewed all penile biopsies performed between January 1, 2007 and December 31, 2015 and studied the causes of the nonvenereal penile dermatoses...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29619128/the-pathophysiological-mechanisms-and-the-quest-for-biomarkers-in-psoriasis-a-stress-related-skin-disease
#5
REVIEW
Mircea Tampa, Maria-Isabela Sarbu, Madalina-Irina Mitran, Cristina-Iulia Mitran, Clara Matei, Simona-Roxana Georgescu
Psoriasis is a physically, emotionally, and socially invalidating multifactorial disorder, with a significant impact on the patients' quality of life. Stress is one of the leading triggers for psoriasis and has been associated with disease onset and subsequent flare-ups, while the flare-ups by themselves often lead to psychological discomfort. The treatment of psoriasis is individualized, depending on the patients' measurable severity of illness, as well as the impact the skin condition has on patients' quality of life, as assessed by standardized questionnaires...
2018: Disease Markers
https://www.readbyqxmd.com/read/29614138/common-and-not-so-common-comorbidities-of-psoriasis
#6
M Alan Menter, April W Armstrong, Kenneth B Gordon, Jashin J Wu
Plaque psoriasis is increasingly recognized as a multisystemic disease whose most common comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, overweight/obesity, inflammatory bowel disease, and depression. The presence of such comorbidities affects the therapeutic choices for clinicians. Patients often visit dermatologists more frequently than they do other clinicians, so it is incumbent upon dermatologists to recognize and address early signs of psoriatic comorbidities to prevent further deterioration and improve their patients' quality of life...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29614137/treating-to-target-a-realistic-goal-in-psoriasis
#7
Kenneth B Gordon, April W Armstrong, M Alan Menter, Jashin J Wu
For many patients, the new biologic therapies for psoriasis can improve Psoriasis Area and Severity Index (PASI) scores in a relatively short time. But when results are less than optimal, patients often become frustrated. By providing effective medical treatment using a treat-to-target strategy, clinicians can relieve symptoms and halt disease progression. Although body surface area (BSA) and PASI scores are appropriate for analyzing results of clinical trials, clinicians need to use more patient-centered assessments of patients' progress such as the Dermatology Life Quality Index (DLQI) and Psoriasis Symptom Inventory (PSI), as well as other validated patientreported outcomes, which can enable them to set realistic and achievable goals for individual patients...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29610017/epidermal-barrier-and-oxidative-stress-parameters-improve-during-in-311-nm-narrow-band-uvb-phototherapy-of-plaque-type-psoriasis
#8
Razvigor Darlenski, Evgeniya Hristakieva, Ufuk Aydin, Desisslava Gancheva, Tanya Gancheva, Antoaneta Zheleva, Veselina Gadjeva, Joachim W Fluhr
BACKGROUND: Psoriasis is a multi-systemic inflammatory disease that results from dysregulation between epidermal keratinocyte homeostasis and both innate and acquired immunity. Epidermal barrier defect has been described in psoriatic lesions. Furthermore an imbalance between pro-oxidative stress and antioxidant defense mechanisms are known in psoriasis patients. AIM: The aim of this study was to address the link between disease activity, epidermal barrier and systemic oxidative stress in the course of 311 nm narrow band ultraviolet B (NB-UVB) therapy of psoriasis...
March 21, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29607625/turmeric-tonic-as-a-treatment-in-scalp-psoriasis-a-randomized-placebo-control-clinical-trial
#9
Parichehr Bahraini, Mehdi Rajabi, Parvin Mansouri, Golnaz Sarafian, Reza Chalangari, Zahra Azizian
BACKGROUND: Psoriasis is an autoimmune and recurrent chronic inflammatory skin disorder with a strong genetic basis. The characteristic features are hyperproliferation of keratinocytes, leading to redness, thickening, and scaling of the epidermis followed by itching and the appearance of lesions, which in most cases can affect the patients both medically and psychologically. The scalp is one of the most common sites for psoriasis. This condition is predominantly managed with steroids, which are associated with various side effects...
April 1, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29606893/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in-psoriasis-a-case-study
#10
Kristin Comella, Michelle Parlo, Rosemary Daly, Kellie Dominessy
Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29606665/simultaneous-response-in-several-domains-in-patients-with-psoriatic-disease-treated-with-etanercept-as-monotherapy-or-in-combination-with-conventional-synthetic-disease-modifying-antirheumatic-drugs
#11
Frank Behrens, Lothar Meier, Jörg C Prinz, Jürgen Jobst, Ralph Lippe, Peter-Andreas Löschmann, Hanns-Martin Lorenz
OBJECTIVE: To evaluate patients with psoriatic arthritis (PsA) receiving etanercept (ETN) monotherapy or ETN plus conventional synthetic disease-modifying antirheumatic drugs (csDMARD) to determine the proportion achieving a clinically meaningful response in arthritis, psoriasis, and quality of life simultaneously. METHODS: A prospective, multicenter, 52-week observational study in patients with active PsA evaluated treatment with ETN in clinical practice (ClinicalTrials...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29588575/measuring-the-importance-of-health-domains-in-psoriasis-discrete-choice-experiment-versus-rating-scales
#12
Mandy Gutknecht, Marthe-Lisa Schaarschmidt, Marion Danner, Christine Blome, Matthias Augustin
Background: Psoriasis affects different aspects of health-related quality of life (eg, physical, psychological, and social impairments); these health domains can be of different importance for patients. The importance of domains can be measured with the Patient Benefit Index (PBI). This questionnaire weights the achievement of treatment goals by Likert scales (0, "not important at all" to 4, "very important") using the Patient Needs Questionnaire (PNQ). Treatment goals assessed with the PBI have been assigned to five health domains; the importance of each domain can be calculated as the average importance of the respective treatment goals...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29579453/survival-of-second-line-biologics-in-psoriasis-the-british-badbir-registry-data-informs-daily-practice
#13
Alexander A Navarini, Lars E French
Psoriasis is one of the most chronic diseases in dermatology. Only a small percentage of patients ever experience relapse-free survival. The constant presence of plaques and comorbidities that affect the cardiovascular system, joints, and other organs greatly impair patients' quality of life. In addition, the life expectancy of psoriatic patients is shortened by several years. Hence, long-term and ideally systemic treatment with minimal adverse effects may be warranted.
April 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29578628/assessment-of-two-screening-tools-to-identify-psoriatic-arthritis-in-patients-with-psoriasis
#14
L C Coates, L J Savage, H Chinoy, P M Laws, C R Lovell, E Korendowych, F Mahmood, H R Mathieson, D McGonagle, R B Warren, R Waxman, P S Helliwell
BACKGROUND: Many patients with psoriasis have undiagnosed psoriatic arthritis. Low specificity is found with many PsA screening tools. A new instrument, the CONTEST questionnaire, was developed utilising the most discriminative items from existing instruments. OBJECTIVE: The aim of this study was to compare the CONTEST and PEST screening tools. METHODS: People attending secondary care clinics with psoriasis, but not PsA, completed the questionnaires, were assessed for function and quality of life, and had a physical examination...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29569397/guselkumab-a-human-interleukin-23-monoclonal-antibody-in-japanese-patients-with-generalized-pustular-psoriasis-and-erythrodermic-psoriasis-efficacy-and-safety-analyses-of-a-52-week-phase-3-multicenter-open-label-study
#15
Shigetoshi Sano, Hiroshi Kubo, Hitomi Morishima, Ryosuke Goto, Richuan Zheng, Hidemi Nakagawa
Generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP) are the rare and severe subtypes of psoriasis, which are often difficult to treat. The aim of this phase 3, open-label study was to evaluate efficacy and safety of guselkumab, a human interleukin-23 monoclonal antibody, in Japanese patients with GPP and EP. Guselkumab 50 mg was administrated to GPP (n = 10) and EP (n = 11) patients at weeks 0, 4 and thereafter every 8 weeks (q8w). Beginning at week 20, patients were escalated to 100 mg q8w if they met the dose escalation criteria...
March 22, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29565192/pharmacotherapeutic-approaches-for-treating-psoriasis-in-difficult-to-treat-areas
#16
Dario Kivelevitch, Jillian Frieder, Ian Watson, So Yeon Paek, M Alan Menter
Despite great therapeutic advancements in psoriasis, four notable difficult-to-treat areas including the scalp, nails, intertriginous (including genitals), and palmoplantar regions, pose a challenge to both physicians and patients. Localized disease of these specific body regions inflicts a significant burden on patients' quality of life and requires an adequate selection of treatments. Areas covered: This manuscript discusses appropriate therapies and important treatment considerations for these difficult-to-treat areas based on the available clinical data from the literature...
March 22, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29529105/a-review-of-neurologic-complications-of-biologic-therapy-in-plaque-psoriasis
#17
Elaine J Lin, Shivani Reddy, Vidhi V Shah, Jashin J Wu
The use of biologic medications has represented a great advancement in the treatment of moderate to severe plaque psoriasis and has improved patients' quality of life. Despite the increasing popularity of biologics, their neurological side effects have been a constant concern. Reports of demyelinating diseases associated with tumor necrosis factor α (TNF-α) inhibitors continue to accumulate. Additionally, efalizumab was withdrawn from the market in 2009 for causing progressive multifocal leukoencephalopathy (PML)...
January 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29527268/outcomes-assessment-of-hepatitis-c-virus-positive-psoriatic-patients-treated-using-pegylated-interferon-in-combination-with-ribavirin-compared-to-new-direct-acting-antiviral-agents
#18
Giovanni Damiani, Chiara Franchi, Paolo Pigatto, Andrea Altomare, Alessia Pacifico, Stephen Petrou, Sebastiano Leone, Maria Caterina Pace, Marco Fiore
AIM: To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C (CHC) treated with new Direct-Acting Antiviral agents (DAAs) compared to pegylated interferon-2α plus ribavirin (P/R) therapy. METHODS: This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus (HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017...
February 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29516409/multidisciplinary-management-of-spondyloarthritis-related-immune-mediated-inflammatory-disease
#19
Fernando Rizzello, Ignazio Olivieri, Alessandro Armuzzi, Fabio Ayala, Vincenzo Bettoli, Luca Bianchi, Luca Cimino, Antonio Costanzo, Antonio Cristaudo, Salvatore D'Angelo, Marco Daperno, Anna Chiara Fostini, Mauro Galeazzi, Michele Gilio, Paolo Gionchetti, Paolo Gisondi, Ennio Lubrano, Antonio Marchesoni, Annamaria Offidani, Ambrogio Orlando, Daniela Pugliese, Carlo Salvarani, Raffaele Scarpa, Maurizio Vecchi, Giampiero Girolomoni
INTRODUCTION: Immune-mediated inflammatory diseases (IMIDs) are chronic autoimmune conditions that share common pathophysiologic mechanisms. The optimal management of patients with IMIDs remains challenging because the coexistence of different conditions requires the intervention of several specialists. The aim of this study was to develop a series of statements defining overarching principles that guide the implementation of a multidisciplinary approach for the management of spondyloarthritis (SpA)-related IMIDs including SpA, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis and uveitis...
March 7, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29516365/brodalumab-a-review-in-moderate-to-severe-plaque-psoriasis
#20
Hannah A Blair
Brodalumab (Kyntheum® ) is a human anti-interleukin-17 receptor A (IL-17RA) monoclonal antibody available for use in patients with moderate to severe plaque psoriasis. In the phase III AMAGINE trials in this patient population, 12 weeks of induction therapy with subcutaneous brodalumab was superior to placebo in terms of the proportion of patients with ≥ 75% improvement in the Psoriasis Area and Severity Index score (PASI 75) and the proportion of patients with a static Physician Global Assessment score of 0 or 1...
March 8, 2018: Drugs
keyword
keyword
65639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"