Mark Lucock, Zoë Yates, Charlotte Martin, Jeong-Hwa Choi, Lyndell Boyd, Sa Tang, Nenad Naumovski, John Furst, Paul Roach, Nina Jablonski, George Chaplin, Martin Veysey
BACKGROUND AND OBJECTIVES: Vitamin D and folate are highly UV sensitive, and critical for maintaining health throughout the lifecycle. This study examines whether solar irradiance during the first trimester of pregnancy influences vitamin D receptor (VDR) and nuclear folate gene variant occurrence, and whether affected genes influence late-life biochemical/clinical phenotypes. METHODOLOGY: 228 subjects were examined for periconceptional exposure to solar irradiance, variation in vitamin D/folate genes (polymerase chain reaction (PCR)), dietary intake (food frequency questionnaire (FFQ)) and important adult biochemical/clinical phenotypes...
January 2014: Evolution, Medicine, and Public Health