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https://www.readbyqxmd.com/read/29924353/genetic-basis-of-resistance-to-avian-influenza-in-different-commercial-varieties-of-layer-chickens
#1
Wioleta Drobik-Czwarno, Anna Wolc, Janet E Fulton, Tomasz Jankowski, Jesus Arango, Neil P O'Sullivan, Jack C M Dekkers
An outbreak of H5N2 highly pathogenic avian influenza (HPAI) in 2015, resulting in mandatory euthanization of millions of chickens, was one of the most fatal in the US history. The aim of this study was to detect genes associated with survival following natural infection with HPAI during this outbreak. Blood samples were collected from 274 individuals from 3 commercial varieties of White Leghorn. Survivors and age and genetics matched non-affected controls from each variety were included in the comparison. All individuals were genotyped on the 600k SNP array...
June 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29922681/geographical-and-historical-patterns-in-the-emergences-of-novel-highly-pathogenic-avian-influenza-hpai-h5-and-h7-viruses-in-poultry
#2
Madhur S Dhingra, Jean Artois, Simon Dellicour, Philippe Lemey, Gwenaelle Dauphin, Sophie Von Dobschuetz, Thomas P Van Boeckel, David M Castellan, Subhash Morzaria, Marius Gilbert
Over the years, the emergence of novel H5 and H7 highly pathogenic avian influenza viruses (HPAI) has been taking place through two main mechanisms: first, the conversion of a low pathogenic into a highly pathogenic virus, and second, the reassortment between different genetic segments of low and highly pathogenic viruses already in circulation. We investigated and summarized the literature on emerging HPAI H5 and H7 viruses with the aim of building a spatio-temporal database of all these recorded conversions and reassortments events...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29921911/influenza-viral-vectors-expressing-two-kinds-of-ha-proteins-for-bivalent-vaccines-against-clade-2-3-4-4-and-clade-2-3-2-1-h5-hpaivs
#3
Guangyu Hou, Jinping Li, Yan Wang, Suchun Wang, Cheng Peng, Xiaohui Yu, Jihui Jin, Wenming Jiang
The H5 highly pathogenic avian influenza viruses (HPAIVs) in China pose a serious challenge to public health and the poultry industry. In this study, we constructed a replication-competent recombinant influenza A virus of clade 2.3.4.4 Н5N1 expressing the clade 2.3.2.1 H5 HA1 protein from a tricistronic NS segment. We used a truncated NS1 protein of 73 amino acids combined with a heterologous dimerization domain to increase protein stability. H5 HA1 and nuclear export information were fused in frame with a truncated NS1 open reading frame, separated by 2A self-processing sites...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29920971/phylogenetic-and-molecular-analysis-of-highly-pathogenic-avian-influenza-h5n8-and-h5n5-viruses-detected-in-poland-in-2016-2017
#4
Edyta Świętoń, Krzysztof Śmietanka
Sixty-five poultry outbreaks and sixty-eight events in wild birds were reported during the highly pathogenic H5N8/H5N5 avian influenza epidemic in Poland in 2016-2017. The analysis of all gene segment sequences of selected strains revealed cocirculation of at least four different genome configurations (genotypes) generated through reassortment of clade 2.3.4.4 H5N8 viruses detected in Russia and China in mid-2016. The geographical and temporal distribution of three H5N8 genotypes indicates separate introductions...
June 19, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29920398/national-surveillance-and-control-costs-for-highly-pathogenic-avian-influenza-h5n1-in-poultry-a-benefit-cost-assessment-for-a-developing-economy-nigeria
#5
Olubunmi G Fasanmi, Olugbenga O Kehinde, Agnes T Laleye, Bassey Ekong, Syed S U Ahmed, Folorunso O Fasina
We conducted benefit-cost analysis of outbreak and surveillance costs for HPAI H5N1in poultry in Nigeria. Poultry's death directly cost US$ 939,734.0 due to outbreaks. The integrated disease surveillance and response originally created for comprehensive surveillance and laboratory investigation of human diseases was adapted for HPAI H5N1 in poultry. Input data were obtained from the field, government documents and repositories and peer-reviewed publications. Actual/forecasted bird numbers lost were integrated into a financial model and estimates of losses were calculated...
June 13, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29915512/the-study-of-effect-of-didecyl-dimethyl-ammonium-bromide-on-bacterial-and-viral-decontamination-for-biosecurity-in-the-animal-farm
#6
Tippawan Jantafong, Sakchai Ruenphet, Darsaniya Punyadarsaniya, Kazuaki Takehara
Aim: The aim of this study was to determine the effectiveness of the fourth-generation quaternary ammonium compounds, didecyl dimethyl ammonium bromide (DDAB), on the efficacy of bacterial and viral decontamination against pathogens commonly found in livestock industry including Salmonella infantis (SI), Escherichia coli , and avian influenza virus (AIV). Materials and Methods: The DDAB was prepared at 500, 250, and 125 parts per million (ppm) for absent and present organic material...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29914558/risk-factors-for-avian-influenza-virus-in-backyard-poultry-flocks-and-environments-in-zhejiang-province-china-a-cross-sectional-study
#7
Xiao-Xiao Wang, Wei Cheng, Zhao Yu, She-Lan Liu, Hai-Yan Mao, En-Fu Chen
BACKGROUND: Human infection of avian influenza virus (AIV) remains a great concern. Although live poultry markets are believed to be associated with human infections, ever more infections have been reported in rural areas with backyard poultry, especially in the fifth epidemic of H7N9. However, limited information is available on backyard poultry infection and surrounding environmental contamination. METHODS: Two surveillance systems and a field survey were used to collect data and samples in Zhejiang Province...
June 19, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29914481/avian-influenza-a-h5n1-outbreaks-in-different-poultry-farm-types-in-egypt-the-effect-of-vaccination-closing-status-and-farm-size
#8
Jean Artois, Carla Ippoliti, Annamaria Conte, Madhur S Dhingra, Pastor Alfonso, Abdelgawad El Tahawy, Ahmed Elbestawy, Hany F Ellakany, Marius Gilbert
BACKGROUND: The Avian Influenza A (H5N1) virus is endemic in poultry in Egypt. The winter of 2014/2015 was particularly worrying as new clusters of HPAI A (H5N1) virus emerged, leading to an important number of AI A (H5N1) outbreaks in poultry farms and sporadic human cases. To date, few studies have investigated the distribution of HPAI A (H5N1) outbreaks in Egypt in relation to protective / risk factors at the farm level, a gap we intend to fill. The aim of the study was to analyse passive surveillance data that were based on observation of sudden and high mortality of poultry or drop in duck or chicken egg production, as a basis to better understand and discuss the risk of HPAI A (H5N1) presence at the farm level in large parts of the Nile Delta...
June 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29912711/poultry-infection-with-influenza-viruses-of-wild-bird-origin-china-2016
#9
Zhijun Yu, Kaihui Cheng, Yuwei Gao
Migratory birds may play a role in transmission of avian influenza virus. We report the infection of black-tailed gulls and chickens in eastern China with avian influenza (H13N2) and (H13N8) viruses. We found that these H13 viruses were transmitted from migratory birds to domestic poultry.
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912710/highly-pathogenic-avian-influenza-a-h5n8-virus-cameroon-2017
#10
Abel Wade, Simon Dickmu Jumbo, Bianca Zecchin, Alice Fusaro, Taiga Taiga, Alice Bianco, Poueme N Rodrigue, Angela Salomoni, Jean Marc Feussom Kameni, Gianpiero Zamperin, Robert Nenkam, Yacouba Foupouapouognigni, Souley Abdoulkadiri, Yaya Aboubakar, Lidewij Wiersma, Giovanni Cattoli, Isabella Monne
Highly pathogenic avian influenza A(H5N8) viruses of clade 2.3.4.4 spread into West Africa in late 2016 during the autumn bird migration. Genetic characterization of the complete genome of these viruses detected in wild and domestic birds in Cameroon in January 2017 demonstrated the occurrence of multiple virus introductions.
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912708/avian-influenza-a-virus-infection-among-workers-at-live-poultry-markets-china-2013-2016
#11
Mai-Juan Ma, Teng Zhao, Shan-Hui Chen, Xian Xia, Xiao-Xian Yang, Guo-Lin Wang, Li-Qun Fang, Guan-Yuan Ma, Meng-Na Wu, Yan-Hua Qian, Natalie E Dean, Yang Yang, Bing Lu, Wu-Chun Cao
We conducted a 3-year longitudinal serologic survey on an open cohort of poultry workers, swine workers, and general population controls to assess avian influenza A virus (AIV) seroprevalence and seroincidence and virologic diversity at live poultry markets (LPMs) in Wuxi City, Jiangsu Province, China. Of 964 poultry workers, 9 (0.93%) were seropositive for subtype H7N9 virus, 18 (1.87%) for H9N2, and 18 (1.87%) for H5N1. Of 468 poultry workers followed longitudinally, 2 (0.43%), 13 (2.78%), and 7 (1.5%) seroconverted, respectively; incidence was 1...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912707/highly-pathogenic-avian-influenza-a-h5n8-virus-democratic-republic-of-the-congo-2017
#12
Augustin T Twabela, Georges M Tshilenge, Yoshiro Sakoda, Masatoshi Okamatsu, Ezekiel Bushu, Philippe Kone, Lidewij Wiersma, Gianpiero Zamperin, Alessandra Drago, Bianca Zecchin, Isabella Monne
In 2017, highly pathogenic avian influenza A(H5N8) virus was detected in poultry in the Democratic Republic of the Congo. Whole-genome phylogeny showed the virus clustered with H5N8 clade 2.3.4.4B strains from birds in central and southern Asia. Emergence of this virus in central Africa represents a threat for animal health and food security.
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912683/diversity-of-influenza-a-h5n1-viruses-in-infected-humans-northern-vietnam-2004-2010
#13
Hirotaka Imai, Jorge M Dinis, Gongxun Zhong, Louise H Moncla, Tiago J S Lopes, Ryan McBride, Andrew J Thompson, Wenjie Peng, Mai Thi Q Le, Anthony Hanson, Michael Lauck, Yuko Sakai-Tagawa, Shinya Yamada, Julie Eggenberger, David H O'Connor, Yasuo Suzuki, Masato Hatta, James C Paulson, Gabriele Neumann, Thomas C Friedrich, Yoshihiro Kawaoka
Influenza viruses exist in each host as a collection of genetically diverse variants, which might enhance their adaptive potential. To assess the genetic and functional diversity of highly pathogenic avian influenza A(H5N1) viruses within infected humans, we used deep-sequencing methods to characterize samples obtained from infected patients in northern Vietnam during 2004-2010 on different days after infection, from different anatomic sites, or both. We detected changes in virus genes that affected receptor binding, polymerase activity, or interferon antagonism, suggesting that these factors could play roles in influenza virus adaptation to humans...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912453/induction-of-cross-clade-antibody-and-t-cell-responses-by-an-mva-based-influenza-h5n1-vaccine-in-a-randomized-phase-i-iia-clinical-trial
#14
Rory D de Vries, Arwen F Altenburg, Nella J Nieuwkoop, Erwin de Bruin, Stella E van Trierum, Mark R Pronk, Mart M Lamers, Mathilde Richard, David F Nieuwenhuijse, Marion P G Koopmans, Joost H C M Kreijtz, Ron A M Fouchier, Albert D M E Osterhaus, Gerd Sutter, Guus F Rimmelzwaan
Background: Highly pathogenic avian influenza viruses continue to circulate in poultry and wild birds and occasionally infect humans, sometimes with fatal outcome. Development of vaccines is a priority to prepare for potential pandemics, however complicated by antigenic variation of the surface glycoprotein hemagglutinin. We report the immunological profile induced by human immunization with Modified Vaccinia virus Ankara expressing the hemagglutinin gene of H5N1 virus A/Vietnam/1194/04 (rMVA-H5)...
April 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29910565/proteomic-analysis-of-avian-influenza-a-h7n9-patients-within-a-family-cluster
#15
Yang Zheng, Xiaomin Lou, Peng Yang, Weixian Shi, Yanda Chu, Meishuang Yan, Cuicui Jiang, Di Wu, Yang Pan, Jiachen Zhao, Yang Li, Yusheng Dong, Lijuan Chen, Siqi Liu, Quanyi Wang
Background: To date, there is limited information on the progression of human infections of avian influenza virus A (H7N9). This study investigated differential blood protein profiling of a H7N9-infected family cluster to find a slice of crucial proteins concerning disease attack and virus clearance. Materials and Methods: Plasma samples from one family cluster (including one index case and one asymptomatic case) were collected at four time points. The protein profiles were identified by isobaric tagging for relative and absolute quantification-based quantitative differential LC/MS/MS, and their functional annotations were analyzed by PANTHER and STRING tools...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29909041/influenza-virus
#16
Edward C Hutchinson
This infographic briefly summarises the natural history, replication cycle, and pathogenesis of influenza viruses, the cause of seasonal influenza and of influenza pandemics. Influenza viruses infect many vertebrates, with Influenza A, B and C viruses (IAV, IBV, and ICV) infecting humans. High mutation rates allow the evasion of immunity. IAV from different host species can 'reassort' their segmented genomes, producing pandemic strains that are antigenically novel but otherwise well adapted to humans. The 'Great Influenza' pandemic of 1918 remains the worst outbreak of infectious disease in history...
June 13, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29908209/the-second-generation-thiazolide-haloxanide-is-a-potent-inhibitor-of-avian-influenza-virus-replication
#17
Simone La Frazia, Sara Piacentini, Anna Riccio, Jean Francois Rossignol, M Gabriella Santoro
The emergence of new avian influenza virus (AIV) strains able to infect humans represents a serious threat to global human health. In addition to surveillance and vaccine development, antiviral therapy remains crucial for AIV control; however, the increase in drug-resistant AIV strains underscores the need for novel approaches to anti-influenza chemotherapy. We have previously shown that the thiazolide anti-infective nitazoxanide (NTZ) inhibits influenza A/PuertoRico/8/1934(H1N1) virus replication, and this effect was associated with inhibition of viral hemagglutinin (HA) maturation...
June 13, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29907765/dual-functional-peptide-with-defective-interfering-genes-effectively-protects-mice-against-avian-and-seasonal-influenza
#18
Hanjun Zhao, Kelvin K W To, Hin Chu, Qiulu Ding, Xiaoyu Zhao, Cun Li, Huiping Shuai, Shuofeng Yuan, Jie Zhou, Kin-Hang Kok, Shibo Jiang, Kwok-Yung Yuen
Limited efficacy of current antivirals and antiviral-resistant mutations impairs anti-influenza treatment. Here, we evaluate the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Viral replication is significantly reduced in cell lines transfected with DIG-3. Mice treated with DIG-3 encoded by jetPEI-vector, as prophylaxis and therapeutics against A(H7N7) virus, respectively, have significantly better survivals (80% and 50%) than control mice (0%). We further develop a dual-functional peptide TAT-P1, which delivers DIG-3 with high efficiency and concomitantly exerts antiviral activity by preventing endosomal acidification...
June 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29904657/expression-of-immune-genes-rig-i-and-mx-in-mallard-ducks-infected-with-low-pathogenic-avian-influenza-lpai-a-dataset
#19
Anu S Helin, Michelle Wille, Clara Atterby, Josef Järhult, Jonas Waldenström, Joanne R Chapman
This article provides data on primer sequences used to amplify the innate immune genes RIG-I and Mx and a set of normalizing reference genes in mallards ( Anas platyrhynchos ), and shows which reference genes are stable, per tissue, for our experimental settings. Data on the expressional changes of these two genes over a time-course of infection with low pathogenic avian influenza virus (LPAI) are provided. Individual-level data are also presented, including LPAI infection load, and per tissue gene expression of RIG-I and Mx ...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29900780/a-long-term-serosurvey-of-avian-influenza-h5-among-wild-birds-in-nakhon-sawan-province-thailand
#20
Kanaporn Poltep, Natthaphat Ketchim, Weena Paungpin, Phirom Prompiram, Poonyapat Sedwisai, Tatiyanuch Chamsai, Pilaipan Puthavathana, Parntep Ratanakorn
  An outbreak of HPAIV H5N1 in Nakhon Sawan province, Thailand, in 2004 caused sporadic deaths of Asian openbill storks ( Anastomus oscitans). An investigation was undertaken to determine if this virus occurs and circulates in wild birds in Nakhon Sawan province. Following the outbreak, a widespread serosurvey was conducted using the hemagglutination inhibition assay and microneutralization assay to detect antibodies against AIV H5. From 2007 to 2014, blood was collected from a total of 753 wild birds, representing 10 orders and 44 species...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
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