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https://www.readbyqxmd.com/read/27936463/virus-like-particles-displaying-h5-h7-h9-hemagglutinins-and-n1-neuraminidase-elicit-protective-immunity-to-heterologous-avian-influenza-viruses-in-chickens
#1
Peter Pushko, Irina Tretyakova, Rachmat Hidajat, Aniko Zsak, Klaudia Chrzastek, Terrence M Tumpey, Darrell R Kapczynski
Avian influenza (AI) viruses circulating in wild birds pose a serious threat to public health. Human and veterinary vaccines against AI subtypes are needed. Here we prepared triple-subtype VLPs that co-localized H5, H7 and H9 antigens derived from H5N1, H7N3 and H9N2 viruses. VLPs also contained influenza N1 neuraminidase and retroviral gag protein. The H5/H7/H9/N1/gag VLPs were prepared using baculovirus expression. Biochemical, functional and antigenic characteristics were determined including hemagglutination and neuraminidase enzyme activities...
December 6, 2016: Virology
https://www.readbyqxmd.com/read/27935503/update-on-avian-influenza-in-europe
#2
(no author information available yet)
This article has been prepared by Helen Roberts and colleagues from Defra's International Disease Monitoring Team with Jane Clark, Richard Irvine and Ian Brown of the APHA.
December 3, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27935502/disease-surveillance-in-england-and-wales-november-2016
#3
(no author information available yet)
▪Current and emerging issues: recrudescence of Schmallenberg virus▪Highlights from the scanning surveillance network▪Update on international disease threats▪Focus on avian influenza in EuropeThese are among matters discussed in the Animal and Plant Health Agency's (APHA's) November disease surveillance report.
December 3, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27934828/generation-and-characterisation-of-monoclonal-antibodies-specific-to-avian-influenza-h7n9-haemagglutinin-protein
#4
A Malik, Vva Mallajosyula, N N Mishra, A P Arukha, R Varadarajan, S K Gupta
INTRODUCTION: Emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. A novel avian influenza virus, H7N9, breached the species barrier from infected domestic poultry to humans in 2013 in China. Since then, it has caused numerous infections in humans with a close contact to poultry. MATERIALS AND METHODS: In this study, we describe the preliminary characterisation of five murine monoclonal antibodies (MAbs) developed against recombinant haemagglutinin (rHA) protein of avian H7N9 A/Anhui/1/2013 virus by their Western blot and enzyme-linked immunosorbent assay (ELISA) reactivity and binding affinity...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27934581/severe-acute-respiratory-infection-caused-by-swine-influenza-virus-in-a-child-necessitating-extracorporeal-membrane-oxygenation-ecmo-the-netherlands-october-2016
#5
Pieter L A Fraaij, Enno D Wildschut, Robert J Houmes, Corien M Swaan, Christian J Hoebe, H C C de Jonge, Paulien Tolsma, Isme de Kleer, Suzan D Pas, Bas B Oude Munnink, My V T Phan, Theo M Bestebroer, R Shanty Roosenhoff, Jeroen J A van Kampen, Matthew Cotten, Nancy Beerens, Ron A M Fouchier, Johannes H van den Kerkhof, Aura Timen, Marion P Koopmans
In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir treatment and removal of mucus plugs, the patient fully recovered. Monitoring of more than 80 close unprotected contacts revealed no secondary cases.
December 1, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27933797/nuclear-magnetic-resonance-and-molecular-dynamics-simulation-of-the-interaction-between-recognition-protein-h7-of-the-novel-influenza-virus-h7n9-and-glycan-cell-surface-receptors
#6
Eleonora Macchi, Timothy R Rudd, Rahul Raman, Ram Sasisekharan, Edwin A Yates, Annamaria Naggi, Marco Guerrini, Stefano Elli
Avian influenza A viruses, which can also propagate between humans, present serious pandemic threats, particularly in Asia. The specificity (selectivity) of interactions between the recognition protein hemagglutinin (HA) of the virus capsid and the glycoconjugates of host cells also contributes to the efficient spread of the virus by aerosol between humans. Some avian origin viruses, such as H1N1 (South Carolina 1918), have improved their selectivity for human receptors by mutation in the HA receptor binding site, to generate pandemic viruses...
December 6, 2016: Biochemistry
https://www.readbyqxmd.com/read/27932709/avian-influenza-prevention-zone-declared
#7
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27929750/purification-and-immunogenicity-of-hemagglutinin-from-highly-pathogenic-avian-influenza-virus-h5n1-expressed-in-nicotiana-benthamiana
#8
Teen-Lee Pua, Xiao Ying Chan, Hwei-San Loh, Abdul Rahman Omar, Vidadi Yusibov, Konstantin Musiychuk, Alexandra C Hall, Megan V Coffin, Yoko Shoji, Jessica A Chichester, Hong Bi, Stephen J Streatfield
Highly pathogenic avian influenza (HPAI) H5N1 is an ongoing global health concern due to its severe sporadic outbreaks in Asia, Africa and Europe, which poses a potential pandemic threat. The development of safe and cost-effective vaccine candidates for HPAI is considered the best strategy for managing the disease and addressing the pandemic preparedness. The most potential vaccine candidate is the antigenic determinant of influenza A virus, hemagglutinin (HA). The present research was aimed at developing optimized expression in Nicotiana benthamiana and protein purification process for HA from the Malaysian isolate of H5N1 as a vaccine antigen for HPAI H5N1...
December 8, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27928017/a-temperature-sensitive-live-attenuated-canine-influenza-virus-h3n8-vaccine
#9
Aitor Nogales, Laura Rodriguez, Caroline Chauché, Kai Huang, Emma C Reilly, David J Topham, Pablo R Murcia, Colin R Parrish, Luis Martínez-Sobrido
: Canine influenza is a respiratory disease of dogs caused by canine influenza virus (CIV). CIV subtypes responsible for influenza in dogs include H3N8, which originated from the transfer of H3N8 equine influenza virus to dogs; and the H3N2 CIV, which is an avian-origin virus that adapted to infect dogs. Influenza infections are most effectively prevented through vaccination to reduce transmission and future infection. Currently, only inactivated influenza vaccines (IIVs) are available for the prevention of CIV in dogs...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27927274/characterization-of-avian-influenza-a-h7n9-virus-prevalence-in-humans-and-poultry-in-huai-an-china-molecular-epidemiology-phylogenetic-and-dynamics-analyses
#10
Peng Fei Yang, Qing Li Yan, Chun Cheng Liu, Ya Dong Xing, Min Hui Zhang, Qiang Gao, Hao Yu, Hai Bo Yao, Nan Jiang He
OBJECTIVE: To trace the source of human H7N9 cases in Huai'an and elucidate the genetic characterization of Huai'an strains associated with both humans and birds in live poultry market. METHODS: An enhanced surveillance was implemented when the first human H7N9 case was confirmed in Huai'an. Clinical specimens, cloacal swabs, and fecal samples were collected and screened by real-time reverse transcription-polymerase chain reaction (RT-PCR) for H7N9 virus. The positive samples were subjected to further RT-PCR and genome sequencing...
October 2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27926816/identification-of-polymerase-gene-mutations-that-affect-viral-replication-in-h5n1-influenza-viruses-isolated-from-pigeons
#11
Emad Mohamed Elgendy, Yasuha Arai, Norihito Kawashita, Tomo Daidoji, Tatsuya Takagi, Madiha Salah Ibrahim, Takaaki Nakaya, Yohei Watanabe
Highly pathogenic avian influenza virus H5N1 infects a wide range of host species, with a few cases of sporadic pigeon infections reported in the Middle East and Asia. However, the role of pigeons in the ecology and evolution of H5N1 viruses remains unclear. We previously reported two H5N1 virus strains, isolated from naturally infected pigeons in Egypt, that have several unique mutations in their viral polymerase genes. Here, we investigated the effect of these mutations on H5N1 polymerase activity and viral growth and identified three mutations that affected viral polymerase activity...
December 7, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27924808/avian-h11-influenza-virus-isolated-from-domestic-poultry-in-a-colombian-live-animal-market
#12
Pedro Jiménez-Bluhm, Erik A Karlsson, Karl A Ciuoderis, Valerie Cortez, Shauna A Marvin, Christopher Hamilton-West, Stacey Schultz-Cherry, Jorge E Osorio
Live animal markets (LAMs) are an essential source of food and trade in Latin American countries; however, they can also serve as 'hotbeds' for the emergence and potential spillover of avian influenza viruses (AIV). Despite extensive knowledge of AIV in Asian LAMs, little is known about the prevalence South American LAMs. To fill this gap in knowledge, active surveillance was carried out at the major LAM in Medellin, Colombia between February and September 2015. During this period, overall prevalence in the market was 2...
December 7, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27923953/seroevidence-for-a-high-prevalence-of-subclinical-infection-with-avian-influenza-a-h5n1-virus-among-workers-in-a-live-poultry-market-in-indonesia
#13
Kazufumi Shimizu, Laksmi Wulandari, Emmanuel D Poetranto, Retno A Setyoningrum, Resti Yudhawati, Amelia Sholikhah, Aldise M Nastri, Anna L Poetranto, Adithya Y R Candra, Edith F Puruhito, Yusuke Takahara, Yoshiaki Yamagishi, Masaoki Yamaoka, Hak Hotta, Takako Ustumi, Maria I Lusida, Soetjipto, Yohko K Shimizu, Gatot Soegiarto, Yasuko Mori
BACKGROUND:  In Indonesia, highly pathogenic avian influenza A(H5N1) virus has become endemic in poultry and has caused sporadic deadly infections in human. Since 2012, we have conducted fixed-point surveillance of avian influenza viruses at a live-poultry market in East Java, Indonesia. In this study, we examined the seroprevalence of avian influenza A(H5N1) virus infection among market workers. METHODS:  Sera were collected from 101 workers in early 2014 and examined for antibody activity against avian A(H5N1) Eurasian lineage virus by a hemagglutination-inhibition (HI) assay...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27922116/risk-assessment-of-recent-egyptian-h5n1-influenza-viruses
#14
A-S Arafa, S Yamada, M Imai, T Watanabe, S Yamayoshi, K Iwatsuki-Horimoto, M Kiso, Y Sakai-Tagawa, M Ito, T Imamura, N Nakajima, K Takahashi, D Zhao, K Oishi, A Yasuhara, C A Macken, G Zhong, A P Hanson, S Fan, J Ping, M Hatta, T J S Lopes, Y Suzuki, M El-Husseiny, A Selim, N Hagag, M Soliman, G Neumann, H Hasegawa, Y Kawaoka
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are enzootic in poultry populations in different parts of the world, and have caused numerous human infections in recent years, particularly in Egypt. However, no sustained human-to-human transmission of these viruses has yet been reported. We tested nine naturally occurring Egyptian H5N1 viruses (isolated in 2014-2015) in ferrets and found that three of them transmitted via respiratory droplets, causing a fatal infection in one of the exposed animals...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27919225/comparison-of-the-first-three-waves-of-avian-influenza-a-h7n9-virus-circulation-in-the-mainland-of-the-people-s-republic-of-china
#15
Nijuan Xiang, A Danielle Iuliano, Yanping Zhang, Ruiqi Ren, Xingyi Geng, Bili Ye, Wenxiao Tu, Ch Ao Li, Yong Lv, Ming Yang, Jian Zhao, Yali Wang, Fuqiang Yang, Lei Zhou, Bo Liu, Yuelong Shu, Daxin Ni, Zijian Feng, Qun Li
BACKGROUND: H7N9 human cases were first detected in mainland China in March 2013. Circulation of this virus has continued each year shifting to typical winter months. We compared the clinical and epidemiologic characteristics for the first three waves of virus circulation. METHODS: The first wave was defined as reported cases with onset dates between March 31-September 30, 2013, the second wave was defined as October 1, 2013-September 30, 2014 and the third wave was defined as October 1, 2014-September 30, 2015...
December 5, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27919180/investigation-of-a-mortality-cluster-in-wild-adult-yellow-eyed-penguins-megadyptes-antipodes-at-otago-peninsula-new-zealand
#16
Brett Gartrell, David Agnew, Maurice Alley, Tim Carpenter, Hye Jeong Ha, Laryssa Howe, Stuart Hunter, Kate McInnes, Rex Munday, Roe Wendi, Young Melanie
We investigated an epidemic mortality cluster of yellow-eyed penguins (Megadyptes antipodes) that involved 67 moribund or dead birds found on various beaches of the Otago Peninsula, New Zealand, between January 21 and March 20, 2013. Twenty-four carcases were examined postmortem. Histological lesions of pulmonary, hepatic and splenic erythrophagocytosis and haemosiderosis were found in 23 of 24 birds. Fifteen birds also had haemoglobin-like protein droplets within renal tubular epithelial cells. Despite consistent histological lesions, a cause of death could not be established...
December 6, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27918958/drivers-of-airborne-human-to-human-pathogen-transmission
#17
REVIEW
Sander Herfst, Michael Böhringer, Basel Karo, Philip Lawrence, Nicola S Lewis, Michael J Mina, Charles J Russell, John Steel, Rik L de Swart, Christian Menge
Airborne pathogens - either transmitted via aerosol or droplets - include a wide variety of highly infectious and dangerous microbes such as variola virus, measles virus, influenza A viruses, Mycobacterium tuberculosis, Streptococcus pneumoniae, and Bordetella pertussis. Emerging zoonotic pathogens, for example, MERS coronavirus, avian influenza viruses, Coxiella, and Francisella, would have pandemic potential were they to acquire efficient human-to-human transmissibility. Here, we synthesize insights from microbiological, medical, social, and economic sciences to provide known mechanisms of aerosolized transmissibility and identify knowledge gaps that limit emergency preparedness plans...
December 2, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27918640/label-free-virus-capture-and-release-by-a-microfluidic-device-integrated-with-porous-silicon-nanowire-forest
#18
Yiqiu Xia, Yi Tang, Xu Yu, Yuan Wan, Yizhu Chen, Huaguang Lu, Si-Yang Zheng
Viral diseases are perpetual threats to human and animal health. Detection and characterization of viral pathogens require accurate, sensitive, and rapid diagnostic assays. For field and clinical samples, the sample preparation procedures limit the ultimate performance and utility of the overall virus diagnostic protocols. This study presents the development of a microfluidic device embedded with porous silicon nanowire (pSiNW) forest for label-free size-based point-of-care virus capture in a continuous curved flow design...
December 5, 2016: Small
https://www.readbyqxmd.com/read/27918148/influenza-a-virus-surveillance-in-the-invasive-american-mink-neovison-vison-from-freshwater-ecosystems-northern-spain
#19
H Gholipour, N Busquets, X Fernández-Aguilar, A Sánchez, M P Ribas, G De Pedro, P Lizarraga, O Alarcia-Alejos, C Temiño, O Cabezón
Influenza A viruses (IAVs) are negative-sense, single-stranded and segmented RNA viruses of the Orthomyxoviridae family that may cause acute respiratory disease in a wide range of birds and mammals. Susceptibility of several species within the family Mustelidae to IAVs has been reported as a result of natural or experimental infections. The objectives of this study were to assess whether free-ranging American mink populations from Northern Spain were infected with IAV and try to define the role of this species in the epidemiology of IAV...
December 5, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27916934/immune-related-gene-expression-patterns-in-gpv-or-h9n2-infected-goose-spleens
#20
Shun Chen, Anqi Wang, Lipei Sun, Fei Liu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Kunfeng Sun, Xiaoyue Chen, Anchun Cheng
Goose parvovirus (GPV) and avian influenza virus subtype H9N2 are single-stranded DNA (ssDNA) and single-stranded RNA (ssRNA) viruses, respectively, both of which can spread in goslings and cause a significant economic loss. To explore the comprehensive transcriptome of GPV- or H9N2-infected goose spleens and to understand the immune responses induced by a DNA virus (GPV) or a RNA virus (H9N2), RNA-seq was performed on the spleens of goslings at the fifth day post infection. In the present study, 2604 and 2409 differentially expressed unigenes were identified in the GPV- and H9N2-infected groups, respectively...
December 1, 2016: International Journal of Molecular Sciences
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