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https://www.readbyqxmd.com/read/28079620/clostridium-difficile-infection-and-risk-of-colectomy-in-patients-with-inflammatory-bowel-disease-a-bias-adjusted-meta-analysis
#1
Yingxi Chen, Luis Furuya-Kanamori, Suhail A Doi, Ashwin N Ananthakrishnan, Martyn Kirk
BACKGROUND: Clostridium difficile infection (CDI) is a common complication of inflammatory bowel diseases (IBDs) and is associated with worse outcome. Variable rates of colectomy have been reported among IBD complicated by CDI. We conducted a systematic review and meta-analysis of studies to assess the association between CDI and colectomy among patients with IBD. METHODS: The literature was systematically searched using PubMed from inception through April 2016...
January 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28077355/no-evidence-for-the-use-of-stem-cell-therapy-for-tendon-disorders-a-systematic-review
#2
Haiko I M F L Pas, Maarten H Moen, Hidde J Haisma, Marinus Winters
INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders. METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search...
January 11, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28074789/extracorporeal-membrane-oxygenation-in-severe-influenza-infection-with-respiratory-failure-a-systematic-review-and-meta-analysis
#3
Shashvat Sukhal, Jaskaran Sethi, Malini Ganesh, Pedro A Villablanca, Anita K Malhotra, Harish Ramakrishna
INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) has been extensively used for potentially reversible acute respiratory failure associated with severe influenza A (H1N1) pneumonia; however, it remains an expensive, resource-intensive therapy, with a high associated mortality. This systematic review and meta-analysis aims to summarize and pool outcomes data available in the published literature to guide clinical decision-making and further research. METHODS: We conducted a systematic search of MEDLINE (1966 to April 15, 2015), EMBASE (1980 to April 15, 2015), CENTRAL, and Google Scholar for patients with severe H1N1 pneumonia and respiratory failure who received ECMO...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28072562/a-systematic-review
#4
Sarah Drejet, Stacey Halum, Matthew Brigger, Elaine Skopelja, Noah P Parker
Objectives (1) To systematically identify studies evaluating the use of intralesional cidofovir or bevacizumab as an adjunct in adult recurrent respiratory papillomatosis, determine disease severity and functional outcomes, and assess study quality. (2) To compare outcomes between the 2 adjuncts. Data Sources Ovid Medline, EMBASE, Scopus, and Clinical-Trials.gov . Review Methods Data sources were systematically searched. A priori inclusion and exclusion criteria were instituted. Quality was evaluated with the Newcastle-Ottawa Quality Assessment Scale...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28061999/newcastle-disease-virus-from-domestic-mink-china-2014
#5
Panpan Zhao, Lingshuang Sun, Xiao Sun, Siwen Li, Wen Zhang, Laura A Pulscher, Hongliang Chai, Mingwei Xing
Newcastle disease virus (NDV) is a pathogen that most often infects poultry species. In investigating a 2014 outbreak of encephalitis and death among farmed mink (Mustela vison), we found pathological and later experimental evidence that NDV can infect and cause severe encephalitic and pneumonic disease in these animals. Our findings confirm the host range of NDV.
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28061505/effectiveness-of-the-23-valent-pneumococcal-polysaccharide-vaccine-ppv23-against-pneumococcal-disease-in-the-elderly-systematic-review-and-meta-analysis
#6
Gerhard Falkenhorst, Cornelius Remschmidt, Thomas Harder, Eva Hummers-Pradier, Ole Wichmann, Christian Bogdan
BACKGROUND: Routine vaccination of elderly people against pneumococcal diseases is recommended in many countries. National guidelines differ, recommending either the 23-valent polysaccharide vaccine (PPV23), the 13-valent conjugate vaccine (PCV13) or both. Considering the ongoing debate on the effectiveness of PPV23, we performed a systematic literature review and meta-analysis of the vaccine efficacy/effectiveness (VE) of PPV23 against invasive pneumococcal disease (IPD) and pneumococcal pneumonia in adults aged ≥60 years living in industrialized countries...
2017: PloS One
https://www.readbyqxmd.com/read/28057380/current-and-future-vaccines-and-vaccination-strategies-against-infectious-laryngotracheitis-ilt-respiratory-disease-of-poultry
#7
Maricarmen García
Infectious laryngotracheitis (ILT) is an economically important respiratory disease of poultry that affects the industry worldwide. Vaccination is the principal tool in the control of the disease. Two types of vaccines, live attenuated and recombinant viral vector, are commercially available. The first generation of GaHV-1 vaccines available since the early 1960's are live viruses, attenuated by continuous passages in cell culture or embryos. These vaccines significantly reduce mortalities and, in particular, the chicken embryo origin (CEO) vaccines have shown to limit outbreaks of the disease...
December 24, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/28052812/newcastle-disease-virus-vectored-infectious-laryngotracheitis-vaccines-protect-commercial-broiler-chickens-in-the-presence-of-maternally-derived-antibodies
#8
Qingzhong Yu, Stephen Spatz, Yufeng Li, Jilong Yang, Wei Zhao, Zhenyu Zhang, Guoyuan Wen, Maricarmen Garcia, Laszlo Zsak
Newcastle disease virus (NDV) recombinants expressing the infectious laryngotracheitis virus (ILTV) glycoproteins B and D have previously been demonstrated to confer complete clinical protection against virulent ILTV and NDV challenges in naive chickens. We extended this study to assess whether maternally derived antibody (MDA) against NDV and ILTV would interfere with protection in vaccinated broiler chickens. Chickens with a mean NDV MDA hemagglutination inhibition (HI) titer of 6.4 (log2) and detectable ILTV neutralization (VN) antibodies at hatch were vaccinated with rLS/ILTV-gB or rLS/ILTV-gD at 1 or 10day of age (DOA) or on both days...
January 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28051339/depression-in-patients-with-peripheral-arterial-disease-a-systematic-review
#9
Diana P Brostow, Megan L Petrik, Amy J Starosta, Stephen W Waldo
OBJECTIVES: The association between cardiovascular disease and depression is well-established. Peripheral arterial disease arises from atherosclerosis like other cardiovascular disease, but unlike other cardiovascular disease, it impairs ambulation and lower extremity function. Given peripheral arterial disease's unique characteristics and underrepresentation in mental health research, we aimed to: (a) assess the prevalence of depression or depressive symptoms among peripheral arterial disease patients compared to coronary artery disease rates, (b) assess whether an independent association between peripheral arterial disease and depression exists, and (c) identify associated factors that may be targeted for intervention...
January 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28047952/su-f-t-240-epid-based-quality-assurance-for-dosimetric-credentialing
#10
N Miri, J Lehmann, P Vial, P Greer
PURPOSE: We propose a novel dosimetric audit method for clinical trials using EPID measurements at each center and a standardized EPID to dose conversion algorithm. The aim of this work is to investigate the applicability of the EPID method to different linear accelerator, EPID and treatment planning system (TPS) combinations. METHODS: Combination of delivery and planning systems were three Varian linacs including one Pinnacle and two Eclipse TPS and, two ELEKTA linacs including one Pinnacle and one Monaco TPS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047880/su-f-t-328-real-time-in-vivo-dosimetry-of-prostate-sbrt-boost-treatments-using-moskin-detectors
#11
K Legge, D Cutajar, A Wilfert, J Martin, A Rozenfeld, D J O'Connor, P Greer
PURPOSE: To provide in vivo measurements of dose to the anterior rectal wall during prostate SBRT boost treatments using MOSFET detectors. METHODS: Dual MOSkin detectors were attached to a Rectafix rectal sparing device and inserted into patients during SBRT boost treatments. Patients received two boost fractions, each of 9.5-10 Gy and delivered using 2 VMAT arcs. Measurements were acquired for 12 patients. MOSFET voltages were read out at 1 Hz during delivery and converted to dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047126/su-d-201-06-remote-dosmetric-auditing-of-vmat-deliveries-for-clinical-trials-using-epid
#12
K Legge, J Lehmann, P Vial, N Miri, P Greer
PURPOSE: To develop a method for remote dosimetric auditing the delivery of VMAT using EPID which allows for simple, inexpensive and time efficient dosimetric credentialing for clinical trials. METHODS: Remote centers are provided with CT datasets and planning guidelines to produce VMAT plans for a head and neck and a post-prostatectomy treatment. Plans are transferred in the planning system to two virtual water equivalent phantoms, one flat and one cylindrical...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046656/tu-fg-201-06-remote-dosimetric-auditing-for-clinical-trials-using-epid-dosimetry-a-pilot-study
#13
N Miri, J Lehmann, P Vial, K Legge, P Greer
PURPOSE: To perform a pilot study for remote dosimetric credentialing of intensity modulated radiation therapy (IMRT) based clinical trials. The study introduces a novel, time efficient and inexpensive dosimetry audit method for multi-center credentialing. The method employs electronic portal imaging device (EPID) to reconstruct delivered dose inside a virtual flat/cylindrical water phantom. METHODS: Five centers, including different accelerator types and treatment planning systems (TPS), were asked to download two CT data sets of a Head and Neck (H&N) and Postprostatectomy (P-P) patients to produce benchmark plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046016/iron-status-in-attention-deficit-hyperactivity-disorder-a-systematic-review-and-meta-analysis
#14
Yan Wang, Lan Huang, Li Zhang, Yi Qu, Dezhi Mu
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children. However, the pathogenesis of ADHD remains unclear. Iron, an important trace element, is implicated in brain function and dopaminergic activity. Recent studies have investigated the association between iron deficiency and ADHD, but the results are inconsistent. METHODS: A systemic search of MEDLINE, EMBASE, Web of Science and Cochrane Library databases was supplemented by manual searches of references of key retrieved articles...
2017: PloS One
https://www.readbyqxmd.com/read/28043927/risk-factors-for-dislocation-after-revision-total-hip-arthroplasty-a-systematic-review-and-meta-analysis
#15
REVIEW
Lele Guo, Yanjiang Yang, Biao An, Yantao Yang, Linyuan Shi, Xiangzhen Han, Shijun Gao
BACKGROUND: No formal systematic review or meta-analysis was performed up to now to summarize the risk factors of dislocation after revision total hip arthroplasty(THA). AIMS: The present study aimed to quantitatively and comprehensively conclude the risk factors of dislocation after revision total hip arthroplasty. METHODS: A search was applied to CNKI, Embase, Medline, and Cochrane central database (all up to October 2016). All studies assessing the risk factors of dislocation after revision THA without language restriction were reviewed, and qualities of included studies were assessed using the Newcastle-Ottawa Scale...
December 30, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28043009/re-evaluation-the-immune-efficacy-of-newcastle-disease-virus-vaccine-in-commercial-laying-chickens
#16
Qingsong Han, Xiaolong Gao, Pengpeng Wu, Sa Xiao, Xinglong Wang, Peng Liu, Lina Tong, Huafang Hao, Shuxia Zhang, Ruyi Dang, Zengqi Yang
Newcastle disease virus (NDV) infection causes serious problems in laying chickens, like reducing egg production, increasing rate of abnormal eggs in spite of strict vaccination in layer farms program. A new evaluation system is needed to show complete protection of the immunization in laying chickens based on the egg-laying performance, rather than clinical signs of the disease. In this study, laying chickens with different anti-NDV HI (hemagglutination-inhibition) antibody titer after vaccination were divided into different groups...
December 20, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/28042995/can-electroencephalograms-provide-guidance-for-the-withdrawal-of-antiepileptic-drugs-a-meta-analysis
#17
Liwei Tang, Zheng Xiao
OBJECTIVE: The discontinuation of antiepileptic drugs (AEDs) is an important treatment decision for epilepsy patients who have been seizure-free for 2years or longer. Some patients experience seizures relapse after AED withdrawal. The prognostic value of electroencephalograms (EEGs) for seizure relapse following AED withdrawal is controversial. To our knowledge, this is the first meta-analysis to address whether EEG data can be used to guide the discontinuation of AEDs. METHOD: We performed a meta-analysis of cohort studies that reported original EEG data from before AED withdrawal and recurrence after AED-withdrawal...
December 5, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28040246/risk-of-mortality-in-patients-with-giant-cell-arteritis-a-systematic-review-and-meta-analysis
#18
REVIEW
Catherine L Hill, Rachel J Black, Johannes C Nossent, Carlee Ruediger, Leanne Nguyen, Jem V Ninan, Susan Lester
BACKGROUND: Previous studies of mortality associated with GCA have shown conflicting results. We conducted a systematic review and meta-analysis to determine the mortality risk in GCA patients compared to the general population. METHODS: We searched for published studies indexed in MEDLINE and EMBASE and the Cochrane database from inception to June 18, 2015 using the terms "giant cell arteritis" and "temporal arteritis" combined with the terms for death, mortality, and survival...
August 25, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28039484/vascular-endothelial-growth-factor-gene-polymorphisms-and-the-risk-of-renal-cell-carcinoma-evidence-from-eight-case-control-studies
#19
Mancheng Gong, Wenjing Dong, Zhirong Shi, Shaopeng Qiu, Runqiang Yuan
BACKGROUND: Vascular endothelial growth factor (VEGF) protein plays important role in renal cell carcinoma (RCC) development and progression. VEGF gene polymorphisms can alter the protein concentrations and might be associated with renal cell carcinoma risk. However, the results of studies investigating the association between VEGF polymorphisms and renal cell carcinoma risk are inconsistent. Thus, a meta-analysis was performed. METHODS: We selected eligible studies via electronic searches...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28039238/effect-of-beta-blockers-on-perioperative-outcomes-in-vascular-and-endovascular-surgery-a-systematic-review-and-meta-analysis
#20
S Hajibandeh, S Hajibandeh, S A Antoniou, F Torella, G A Antoniou
BACKGROUND: To investigate the role of perioperative beta-blocker use in vascular and endovascular surgery. METHODS: We performed a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement standards. The review protocol was registered with International Prospective Register of Systematic Reviews (registration number:CRD42016038111). We searched electronic databases to identify all randomized controlled trials and observational studies investigating outcomes of patients undergoing vascular and endovascular surgery with or without perioperative beta blockade...
January 2017: British Journal of Anaesthesia
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