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https://www.readbyqxmd.com/read/28271693/comparison-of-the-novel-oxa-48-and-kpc-k-set-assay-and-blue-carba-test-for-the-detection-of-carbapenemase-producing-enterobacteriaceae-using-pcr-as-a-reference-method
#1
Fatma Erdem, Ayham Abulaila, Zerrin Aktas, Oral Oncul
BACKGROUND: Rapid, simple, and accurate laboratory detection of carbapenemases is very important for proper antibiotic therapy and infection control. METHODS: In this study, carbapenem-nonsusceptible Enterobacteriaceae (CRE) isolates were used to evaluate the performance of a new lateral flow immunochromatographic (IC) assay, the OXA-48 and KPC K-SeT assay, and modified Blue-Carba test (BCT) for the rapid detection of OXA-48 carbapenemase in comparison with polymerase chain reaction (PCR) amplification...
March 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28266909/exposure-to-1-2-propanediol-impacts-early-development-of-zebrafish-danio-rerio-and-induces-hyperactivity
#2
Andrey Massarsky, Ayham Abdel, Lilah Glazer, Edward D Levin, Richard T Di Giulio
The use of electronic cigarettes (e-cigarettes) is increasing as an alternative to tobacco burning cigarettes; however, their safety remains to be fully determined. The long-term effects of e-cigarettes are unknown, including the effects of maternal e-cigarette use on pre- and postnatal development. Additional research on the safety of e-cigarettes is needed. Especially useful would be information from high- and moderate-throughput economic model systems. This study investigates the effects of 1,2-propanediol, which was identified as the main component of e-cigarette liquid, on early development of zebrafish (an in vivo high-throughput model system that was recently proposed for the study of tobacco cigarette and e-cigarette toxicity)...
March 7, 2017: Zebrafish
https://www.readbyqxmd.com/read/28193836/post-subdural-hematoma-transient-ischemic-attacks-hypoperfusion-mechanism-supported-by-quantitative-electroencephalography-and-transcranial-doppler-sonography
#3
Ayham M Alkhachroum, Guadalupe Fernandez-Baca Vaca, Sophia Sundararajan, Michael DeGeorgia
No abstract text is available yet for this article.
February 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28007577/-supraventricular-tachycardia-in-newborns-and-its-association-with-gastroesophageal-reflux-disease
#4
Ángeles Fuertes, Ayham Alshweki, Alejandro Pérez-Muñuzuri, María-Luz Couce
INTRODUCTION: Supraventricular tachycardia (SVT) is the most common arrhythmia in the neonatal period, but its association with other triggering processes is not well established. The aim of the study was to analyse the possible relationship between neonatal SVT and gastroesophageal reflux disease (GERD), a condition which was recently linked to atrial arrhythmias. MATERIAL AND METHODS: A retrospective longitudinal descriptive study was conducted over a period of 5years on newborns who were diagnosed with SVT in a level III neonatal unit, assessing morphological aspects, associated symptoms, and treatments received...
December 19, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28002434/correction-first-demonstration-of-antigen-induced-cytokine-expression-by-cd4-1-lymphocytes-in-a-poikilotherm-studies-in-zebrafish-danio-rerio
#5
Sohye Yoon, Suman Mitra, Cathy Wyse, Ayham Alnabulsi, Jun Zou, Eveline M Weerdenburg, Astrid M van der Sar, Difei Wang, Christopher J Secombes, Steve Bird
[This corrects the article DOI: 10.1371/journal.pone.0126378.].
2016: PloS One
https://www.readbyqxmd.com/read/27756756/homozygous-familial-hypercholesterolaemia-in-two-sisters-misdiagnosed-as-rheumatoid-arthritis
#6
Mahmoud H Ayesh Haj Yousef, Ayham Shatnawi, Mai Khdeir, Diala Khaldoon Alawneh
No abstract text is available yet for this article.
October 18, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27663241/finite-element-analysis-of-stress-distribution-on-the-mandible-and-condylar-fracture-osteosynthesis-during-various-clenching-tasks
#7
Loai Hijazi, Wael Hejazi, Mhd Ayham Darwich, Khaldoun Darwich
PURPOSE: The purpose of the study was to evaluate the effect of clenching tasks on the stress and strain of condylar osteosynthesis screws and plates, as well as on the stress, strain distribution and displacement on the whole mandible and bone surrounding screws. METHODS: Three-dimensional finite element models of the mandible, two straight four-hole plates and eight screws were established. Six static clenching tasks were simulated in this study: incisal clench (INC), intercuspal position (ICP), right unilateral molar clench (RMOL), left unilateral molar clench (LMOL), right group function (RGF) and left group function (LGF)...
December 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27539703/analysis-of-interferon-gamma-protein-expression-in-zebrafish-danio-rerio
#8
Sohye Yoon, Ayham Alnabulsi, Ting Yu Wang, Po Tsang Lee, Tzong-Yueh Chen, Steve Bird, Jun Zou, Christopher J Secombes
IFN-γ is a major effector cytokine, produced to induce type I immune responses. It has been cloned in several fish species including zebrafish, however to date few studies have looked at IFN-γ protein expression and bioactivity in fish. Hence, the current study focused on developing a monoclonal antibody (moAb) against zfIFN-γ. We show that the zfIFN-γ moAb specifically recognises E. coli produced recombinant IFN-γ protein and zfIFN-γ produced in transfected HEK293 cells, by Western blot analysis. Next we analysed the production of the native protein following expression induced by PHA stimulation of leukocytes in vitro or antigen re-stimulation in vivo...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27492699/pt-aptt-tt-and-the-hemostatic-safety-threshold-of-dabigatran-and-rivaroxaban
#9
Firas Ibrahim, Leyla Calmette, Ayham Layka, Marie-Hélène Horellou, Élisabeth Mazoyer, Isabelle Gouin-Thibault, Claire Flaujac
The proposals of the Working group on perioperative hemostasis (Groupe d'intérêt en hémostase péri-opératoire (GIHP)) concerning the perioperative management of patients receiving the direct oral anticoagulants (DOACs) are based on the measure of their anticoagulant activities (anti-Xa for rivaroxaban and anti-IIa for dabigatran) with a safety threshold ≤ 30 ng/mL. If the dosage of the drug is not available, proposals are based on the combination of a PT ≥80% and an aPTT ≤1.20. The aim of our study was to evaluate the performance of PT, aPTT and thrombin time to predict values above or below the safety threshold...
August 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27484605/the-effect-of-using-self-ligating-brackets-on-maxillary-canine-retraction-a-split-mouth-design-randomized-controlled-trial
#10
Siba E Hassan, Mohammad Y Hajeer, Osama H Alali, Ayham S Kaddah
INTRODUCTION: The results of previous studies about the efficacy of using self-ligating brackets (SLBs) in controlling canine movement during retraction are not in harmony. Therefore, the current study aimed to compare the effects of using new passive SLBs on maxillary canine retraction with sliding mechanics vs conventional ligating brackets (CLBs) tied with metal ligatures. MATERIALS AND METHODS: The sample comprised 15 adult patients (4 males, 11 females; 18-24 years) requiring bilateral extraction of maxillary first premolars...
June 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27453863/warfarin-induced-leukocytoclastic-vasculitis-and-proteinuria
#11
Khalid Jumean, Ahmad Abu Arqoub, Amer Hawatmeh, Firas Qaqa, Ayham Bataineh, Hamid Shaaban
Warfarin is typically prescribed for patients with thromboembolic diseases and atrial fibrillation. In addition to the complications of bleeding, allergic skin reaction is one of its rare adverse effects. We herein report a case of a 79 year old male patient with leukocytoclastic vasculitis and proteinuria secondary to warfarin. The warfarin was discontinued and oral prednisone therapy was initiated. The cutaneous lesions and the proteinuria resolved thereafter.
January 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27341022/characterisation-of-the-oxysterol-metabolising-enzyme-pathway-in-mismatch-repair-proficient-and-deficient-colorectal-cancer
#12
Rebecca Swan, Abdo Alnabulsi, Beatriz Cash, Ayham Alnabulsi, Graeme I Murray
Oxysterols are oxidised derivatives of cholesterol, formed by the enzymatic activity of several cytochrome P450 enzymes and tumour-derived oxysterols have been implicated in tumour growth and survival. The aim of this study was to profile the expression of oxysterol metabolising enzymes in primary colorectal cancer and assess the association between expression and prognosis.Immunohistochemistry was performed on a colorectal cancer tissue microarray containing 650 primary colorectal cancers using monoclonal antibodies to CYP2R1, CYP7B1, CYP8B1, CYP27A1, CYP39A1, CYP46A1 and CYP51A1, which we have developed...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26965646/a-case-of-neuro-behcet-s-disease-presenting-with-central-neurogenic-hyperventilation
#13
Ayham M Alkhachroum, Saba Saeed, Jaspreet Kaur, Tanzila Shams, Michael A DeGeorgia
BACKGROUND: Behcet's disease is a chronic inflammatory disorder usually characterized by the triad of oral ulcers, genital ulcers, and uveitis. Central to the pathogenesis of Behcet's disease is an autoimmune vasculitis. Neurological involvement, so called "Neuro-Behcet's disease", occurs in 10-20% of patients, usually from a meningoencephalitis or venous thrombosis. CASE REPORT: We report the case of a 46-year-old patient with Neuro-Behcet's disease who presented with central neurogenic hyperventilation as a result of brainstem involvement from venulitis...
March 11, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/26479407/ultrasound-findings-of-carpal-tunnel-syndrome-in-a-hunter-syndrome-patient
#14
Ayham M Alkhachroum, David C Preston
INTRODUCTION: Hunter syndrome (mucopolysaccharidosis II) is a rare genetic disorder. Carpal tunnel syndrome (CTS) is a common finding in these patients. METHODS: We report the ultrasound findings in a 40-year-old Hunter syndrome patient with severe CTS. RESULTS: Marked abnormalities of the median nerve were present proximal to the carpal tunnel with an unusual area of increased echogenicity between enlarged fascicles separating the area of maximal enlargement and the normal median nerve proximally...
January 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/26310969/epilepsy-surgery-in-the-united-states-analysis-of-data-from-the-national-association-of-epilepsy-centers
#15
Kitti Kaiboriboon, Ayham M Malkhachroum, Ahmad Zrik, Ahmad Daif, Nicholas M Schiltz, David M Labiner, Samden D Lhatoo
OBJECTIVE: To examine trends in epilepsy-related surgical procedures performed at major epilepsy centers in the US between 2003 and 2012, and in the service provision infrastructure of epilepsy centers over the same time period. METHODS: We analyzed data from the National Association of Epilepsy Centers' (NAEC) annual surveys. The total annual figures, annual average figures per center and annual rates of each surgical procedure based on US population numbers for that year were calculated...
October 2015: Epilepsy Research
https://www.readbyqxmd.com/read/26183150/the-expression-and-prognostic-significance-of-bcl-2-associated-transcription-factor-1-in-rectal-cancer-following-neoadjuvant-therapy
#16
Gordon T Brown, Beatriz Cash, Ayham Alnabulsi, Leslie M Samuel, Graeme I Murray
AIMS: bcl-2-associated transcription factor 1 (BCLAF1) is a nuclear protein that binds to bcl-related proteins and can induce apoptosis and autophagy. The aim of this study was to investigate the expression of BCLAF1 in a series of rectal cancers following neoadjuvant therapy. METHODS AND RESULTS: Immunohistochemistry was performed on a post-neoadjuvant therapy rectal cancer tissue microarray. It contained rectal cancers (n = 248), lymph node metastases (n = 76), and non-neoplastic rectal mucosal samples (n = 73)...
March 2016: Histopathology
https://www.readbyqxmd.com/read/26161997/multifocal-papillary-thyroid-cancer-increases-the-risk-of-central-lymph-node-metastasis
#17
Ayham Al Afif, Blair A Williams, Mathew H Rigby, Martin J Bullock, S Mark Taylor, Jonathan Trites, Robert D Hart
BACKGROUND: Papillary thyroid cancer (PTC) is the most common thyroid malignancy, with a strong predilection for lymph node metastasis, most commonly to the central neck compartment (level VI). Few studies have evaluated lymph node metastasis in multifocal PTC, and the role of level VI dissection in the management of PTC remains controversial. This retrospective analysis evaluated the rate of level VI lymph node positivity in multifocal PTC, as compared with unifocal disease, in order to inform surgical decision making better...
September 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26126403/understanding-edward-muybridge-historical-review-of-behavioral-alterations-after-a-19th-century-head-injury-and-their-multifactorial-influence-on-human-life-and-culture
#18
REVIEW
Sunil Manjila, Gagandeep Singh, Ayham M Alkhachroum, Ciro Ramos-Estebanez
Edward Muybridge was an Anglo-American photographer, well known for his pioneering contributions in photography and his invention of the "zoopraxiscope," a forerunner of motion pictures. However, this 19th-century genius, with two original patents in photographic technology, made outstanding contributions in art and neurology alike, the latter being seldom acknowledged. A head injury that he sustained changed his behavior and artistic expression. The shift of his interests from animal motion photography to human locomotion and gait remains a pivotal milestone in our understanding of patterns in biomechanics and clinical neurology, while his own behavioral patterns, owing to an injury to the orbitofrontal cortex, remain a mystery even for cognitive neurologists...
July 2015: Neurosurgical Focus
https://www.readbyqxmd.com/read/26102601/new-clasp-assembly-for-distal-extension-removable-partial-dentures-the-reverse-rpa-clasp
#19
REVIEW
Mohammad Ayham Hakkoum
Several clasp types are used in distal extension removable partial dentures. In some cases the terminal abutments have only distal retentive undercuts that can be occupied by bar clasps; however, bar clasps may be contraindicated with no suitable alternative. This article presents a reasonable solution by introducing a new clasp design as a modification to the well-known RPA clasp. The design includes a mesial rest, proximal plate, and buccal retentive arm arising from the rest and extending to reach the distal retentive undercut...
July 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/26083432/first-demonstration-of-antigen-induced-cytokine-expression-by-cd4-1-lymphocytes-in-a-poikilotherm-studies-in-zebrafish-danio-rerio
#20
Sohye Yoon, Suman Mitra, Cathy Wyse, Ayham Alnabulsi, Jun Zou, Eveline M Weerdenburg, Astrid M van der Sar, Difei Wang, Christopher J Secombes, Steve Bird
Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess cells that express TcR and CD4-related genes (that exist in two forms in teleost fish; termed CD4-1 and CD4-2), to date there is no unequivocal demonstration that cells equivalent to Th exist. Thus, in this study we determined whether CD4-1+ lymphocytes can express cytokines typical of Th cells following antigen specific stimulation, using the zebrafish (Danio rerio)...
2015: PloS One
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