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Mahmoud H Ayesh Haj Yousef, Ayham Shatnawi, Mai Khdeir, Diala Khaldoon Alawneh
No abstract text is available yet for this article.
October 18, 2016: BMJ Case Reports
Loai Hijazi, Wael Hejazi, Mhd Ayham Darwich, Khaldoun Darwich
PURPOSE: The purpose of the study was to evaluate the effect of clenching tasks on the stress and strain of condylar osteosynthesis screws and plates, as well as on the stress, strain distribution and displacement on the whole mandible and bone surrounding screws. METHODS: Three-dimensional finite element models of the mandible, two straight four-hole plates and eight screws were established. Six static clenching tasks were simulated in this study: incisal clench (INC), intercuspal position (ICP), right unilateral molar clench (RMOL), left unilateral molar clench (LMOL), right group function (RGF) and left group function (LGF)...
September 23, 2016: Oral and Maxillofacial Surgery
Sohye Yoon, Ayham Alnabulsi, Ting Yu Wang, Po Tsang Lee, Tzong-Yueh Chen, Steve Bird, Jun Zou, Christopher J Secombes
IFN-γ is a major effector cytokine, produced to induce type I immune responses. It has been cloned in several fish species including zebrafish, however to date few studies have looked at IFN-γ protein expression and bioactivity in fish. Hence, the current study focused on developing a monoclonal antibody (moAb) against zfIFN-γ. We show that the zfIFN-γ moAb specifically recognises E. coli produced recombinant IFN-γ protein and zfIFN-γ produced in transfected HEK293 cells, by Western blot analysis. Next we analysed the production of the native protein following expression induced by PHA stimulation of leukocytes in vitro or antigen re-stimulation in vivo...
October 2016: Fish & Shellfish Immunology
Firas Ibrahim, Leyla Calmette, Ayham Layka, Marie-Hélène Horellou, Élisabeth Mazoyer, Isabelle Gouin-Thibault, Claire Flaujac
The proposals of the Working group on perioperative hemostasis (Groupe d'intérêt en hémostase péri-opératoire (GIHP)) concerning the perioperative management of patients receiving the direct oral anticoagulants (DOACs) are based on the measure of their anticoagulant activities (anti-Xa for rivaroxaban and anti-IIa for dabigatran) with a safety threshold ≤ 30 ng/mL. If the dosage of the drug is not available, proposals are based on the combination of a PT ≥80% and an aPTT ≤1.20. The aim of our study was to evaluate the performance of PT, aPTT and thrombin time to predict values above or below the safety threshold...
August 1, 2016: Annales de Biologie Clinique
Siba E Hassan, Mohammad Y Hajeer, Osama H Alali, Ayham S Kaddah
INTRODUCTION: The results of previous studies about the efficacy of using self-ligating brackets (SLBs) in controlling canine movement during retraction are not in harmony. Therefore, the current study aimed to compare the effects of using new passive SLBs on maxillary canine retraction with sliding mechanics vs conventional ligating brackets (CLBs) tied with metal ligatures. MATERIALS AND METHODS: The sample comprised 15 adult patients (4 males, 11 females; 18-24 years) requiring bilateral extraction of maxillary first premolars...
2016: Journal of Contemporary Dental Practice
Khalid Jumean, Ahmad Abu Arqoub, Amer Hawatmeh, Firas Qaqa, Ayham Bataineh, Hamid Shaaban
Warfarin is typically prescribed for patients with thromboembolic diseases and atrial fibrillation. In addition to the complications of bleeding, allergic skin reaction is one of its rare adverse effects. We herein report a case of a 79 year old male patient with leukocytoclastic vasculitis and proteinuria secondary to warfarin. The warfarin was discontinued and oral prednisone therapy was initiated. The cutaneous lesions and the proteinuria resolved thereafter.
January 2016: Journal of Family Medicine and Primary Care
Rebecca Swan, Abdo Alnabulsi, Beatriz Cash, Ayham Alnabulsi, Graeme I Murray
Oxysterols are oxidised derivatives of cholesterol, formed by the enzymatic activity of several cytochrome P450 enzymes and tumour-derived oxysterols have been implicated in tumour growth and survival. The aim of this study was to profile the expression of oxysterol metabolising enzymes in primary colorectal cancer and assess the association between expression and prognosis.Immunohistochemistry was performed on a colorectal cancer tissue microarray containing 650 primary colorectal cancers using monoclonal antibodies to CYP2R1, CYP7B1, CYP8B1, CYP27A1, CYP39A1, CYP46A1 and CYP51A1, which we have developed...
June 22, 2016: Oncotarget
Ayham M Alkhachroum, Saba Saeed, Jaspreet Kaur, Tanzila Shams, Michael A DeGeorgia
BACKGROUND: Behcet's disease is a chronic inflammatory disorder usually characterized by the triad of oral ulcers, genital ulcers, and uveitis. Central to the pathogenesis of Behcet's disease is an autoimmune vasculitis. Neurological involvement, so called "Neuro-Behcet's disease", occurs in 10-20% of patients, usually from a meningoencephalitis or venous thrombosis. CASE REPORT: We report the case of a 46-year-old patient with Neuro-Behcet's disease who presented with central neurogenic hyperventilation as a result of brainstem involvement from venulitis...
2016: American Journal of Case Reports
Ayham M Alkhachroum, David C Preston
INTRODUCTION: Hunter syndrome (mucopolysaccharidosis II) is a rare genetic disorder. Carpal tunnel syndrome (CTS) is a common finding in these patients. METHODS: We report the ultrasound findings in a 40-year-old Hunter syndrome patient with severe CTS. RESULTS: Marked abnormalities of the median nerve were present proximal to the carpal tunnel with an unusual area of increased echogenicity between enlarged fascicles separating the area of maximal enlargement and the normal median nerve proximally...
January 2016: Muscle & Nerve
Kitti Kaiboriboon, Ayham M Malkhachroum, Ahmad Zrik, Ahmad Daif, Nicholas M Schiltz, David M Labiner, Samden D Lhatoo
OBJECTIVE: To examine trends in epilepsy-related surgical procedures performed at major epilepsy centers in the US between 2003 and 2012, and in the service provision infrastructure of epilepsy centers over the same time period. METHODS: We analyzed data from the National Association of Epilepsy Centers' (NAEC) annual surveys. The total annual figures, annual average figures per center and annual rates of each surgical procedure based on US population numbers for that year were calculated...
October 2015: Epilepsy Research
Gordon T Brown, Beatriz Cash, Ayham Alnabulsi, Leslie M Samuel, Graeme I Murray
AIMS: bcl-2-associated transcription factor 1 (BCLAF1) is a nuclear protein that binds to bcl-related proteins and can induce apoptosis and autophagy. The aim of this study was to investigate the expression of BCLAF1 in a series of rectal cancers following neoadjuvant therapy. METHODS AND RESULTS: Immunohistochemistry was performed on a post-neoadjuvant therapy rectal cancer tissue microarray. It contained rectal cancers (n = 248), lymph node metastases (n = 76), and non-neoplastic rectal mucosal samples (n = 73)...
March 2016: Histopathology
Ayham Al Afif, Blair A Williams, Mathew H Rigby, Martin J Bullock, S Mark Taylor, Jonathan Trites, Robert D Hart
BACKGROUND: Papillary thyroid cancer (PTC) is the most common thyroid malignancy, with a strong predilection for lymph node metastasis, most commonly to the central neck compartment (level VI). Few studies have evaluated lymph node metastasis in multifocal PTC, and the role of level VI dissection in the management of PTC remains controversial. This retrospective analysis evaluated the rate of level VI lymph node positivity in multifocal PTC, as compared with unifocal disease, in order to inform surgical decision making better...
September 2015: Thyroid: Official Journal of the American Thyroid Association
Sunil Manjila, Gagandeep Singh, Ayham M Alkhachroum, Ciro Ramos-Estebanez
Edward Muybridge was an Anglo-American photographer, well known for his pioneering contributions in photography and his invention of the "zoopraxiscope," a forerunner of motion pictures. However, this 19th-century genius, with two original patents in photographic technology, made outstanding contributions in art and neurology alike, the latter being seldom acknowledged. A head injury that he sustained changed his behavior and artistic expression. The shift of his interests from animal motion photography to human locomotion and gait remains a pivotal milestone in our understanding of patterns in biomechanics and clinical neurology, while his own behavioral patterns, owing to an injury to the orbitofrontal cortex, remain a mystery even for cognitive neurologists...
July 2015: Neurosurgical Focus
Mohammad Ayham Hakkoum
Several clasp types are used in distal extension removable partial dentures. In some cases the terminal abutments have only distal retentive undercuts that can be occupied by bar clasps; however, bar clasps may be contraindicated with no suitable alternative. This article presents a reasonable solution by introducing a new clasp design as a modification to the well-known RPA clasp. The design includes a mesial rest, proximal plate, and buccal retentive arm arising from the rest and extending to reach the distal retentive undercut...
July 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Sohye Yoon, Suman Mitra, Cathy Wyse, Ayham Alnabulsi, Jun Zou, Eveline M Weerdenburg, Astrid M van der Sar, Difei Wang, Christopher J Secombes, Steve Bird
Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess cells that express TcR and CD4-related genes (that exist in two forms in teleost fish; termed CD4-1 and CD4-2), to date there is no unequivocal demonstration that cells equivalent to Th exist. Thus, in this study we determined whether CD4-1+ lymphocytes can express cytokines typical of Th cells following antigen specific stimulation, using the zebrafish (Danio rerio)...
2015: PloS One
Ayham Deeb, Sulsal-Ul Haque, Olugbenga Olowokure
Pancreatic cancer is known to be one of the most lethal cancers. The majority of patients present with advanced stage disease, making curative approach unachievable. In untreated patients, the median survival does not exceed 6 months in metastatic disease and 10 months in locally advanced disease. Furthermore, the 5-year survival rate remains poor even in patients with early stage disease who are surgical candidates. The detrimental outcome is related to the high potency of developing metastasis which can be detected at diagnosis, when the disease progresses or relapses after surgery...
June 2015: Journal of Gastrointestinal Oncology
Kirubakaran Malapan, Ayham Ghinagow, Anirudh Vij, Po-Chih Chang, Ming-Che Hsin, Chih-Kun Huang
BACKGROUND: Laparoscopic adjustable gastric banded plication (LAGBP) is a novel bariatric procedure which is restrictive and reversible. The aim of this study were to compare two LAGBP techniques and analyze its postoperative outcomes, in order to standardize the procedure. METHODS: Eighty patients who underwent LAGBP were enrolled in this study. Forty patients who underwent LAGBP (group 1) from December 2011 to June 2012 were compared with 40 patients (group 2) who underwent a modified LAGBP technique, which included preserving the right gastroepiploic vessels and uniform plication volume between July 2012 and January 2013...
January 2016: Obesity Surgery
Ali Rodan, Ayham Fayyoumi, Hossam Faris, Jamal Alsakran, Omar Al-Kadi
Recently, telecommunication companies have been paying more attention toward the problem of identification of customer churn behavior. In business, it is well known for service providers that attracting new customers is much more expensive than retaining existing ones. Therefore, adopting accurate models that are able to predict customer churn can effectively help in customer retention campaigns and maximizing the profit. In this paper we will utilize an ensemble of Multilayer perceptrons (MLP) whose training is obtained using negative correlation learning (NCL) for predicting customer churn in a telecommunication company...
2015: TheScientificWorldJournal
Ayham M Alkhachroum, Nayef Kazzaz
A patient with a known biopsy of polyarteritis nodosa diagnosis presented with cyclic fevers, acute kidney injury, and progression of rash from macular to pustular, worsening despite being on antibiotics, without evidence of infection on multiple cultures. The patient had a pathological diagnosis from a skin biopsy of acute generalized exanthematous pustulosis syndrome, with a total resolution of rash, fevers, and acute kidney injury on treatment with pulse steroids.
2015: Journal of Community Hospital Internal Medicine Perspectives
Ayham Al-Afif, Raidan Alyazidi, Sharon A Oldford, Yan Y Huang, Christine A King, Nico Marr, Ian D Haidl, Robert Anderson, Jean S Marshall
BACKGROUND: Respiratory syncytial virus (RSV) causes severe respiratory tract infections, which might have a role in the development of airway hyperreactivity. Mast cells are important effector cells in allergy, with sentinel cell roles in host defense. However, the role of mast cells in response to RSV infection is unknown. OBJECTIVE: Human mast cell responses to RSV were investigated with a view to better understanding the role of mast cells in RSV-induced disease...
November 2015: Journal of Allergy and Clinical Immunology
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