Mehrdad Arjomandi, Siyang Zeng, Jianhong Chen, Surya P Bhatt, Fereidoun Abtin, Igor Barjaktarevic, R Graham Barr, Eugene R Bleecker, Russell G Buhr, Gerard J Criner, Alejandro P Comellas, David J Couper, Jeffrey L Curtis, Mark T Dransfield, Spyridon Fortis, MeiLan K Han, Nadia N Hansel, Eric A Hoffman, John E Hokanson, Robert J Kaner, Richard E Kanner, Jerry A Krishnan, Wassim Labaki, David A Lynch, Victor E Ortega, Stephen P Peters, Prescott G Woodruff, Christopher B Cooper, Russell P Bowler, Robert Paine, Stephen I Rennard, Donald P Tashkin
BACKGROUND: Abnormal lung volumes representing air trapping identify the subset of smokers with preserved spirometry who develop spirometric COPD and adverse outcomes. However, how lung volumes evolve in early COPD as airflow obstruction develops remains unclear. METHODS: To establish how lung volumes change with development of spirometric COPD, we examined lung volumes from the pulmonary function data (seated posture) available in the U.S. Department of Veterans Affairs electronic health records (n=71,356) and lung volumes measured by computed tomography (supine posture) available from COPDGene (n=7,969) and SPIROMICS (n=2,552) cohorts, and studied their cross-sectional distributions and longitudinal changes across airflow obstruction spectrum...
May 16, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation