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Nadia hansel

Sonali Bose, Karina Romero, Kevin J Psoter, Frank C Curriero, Chen Chen, Caroline M Johnson, Deepak Kaji, Patrick N Breysse, D'Ann L Williams, Murugappan Ramanathan, William Checkley, Nadia N Hansel
BACKGROUND: Air pollution exposure may contribute to rhinoconjunctivitis morbidity in children with underlying airways disease. Prior studies have not assessed rhinoconjunctivitis-related quality of life (QOL) in children with asthma chronically exposed to air pollution. METHODS: Children ages 9-19 years with asthma from peri-urban Peru, self-reporting rhinoconjunctivitis symptoms (n = 484), were administered the Rhinoconjunctivitis QOL Questionnaire (RQLQ) at repeated intervals over one year, with scores dichotomized into bothered (>0) and not bothered (= 0)...
2018: PloS One
Michelle R Zeidler, Jennifer L Martin, Eric C Kleerup, Hartmut Schneider, Michael N Mitchell, Nadia N Hansel, Krishna Sundar, Helena Schotland, Robert C Basner, James Wells, Jerry A Krishnan, Gerard J Criner, Stephanie Cristenson, Samuel Krachman, M Safwan Badr
Study Objectives: Sleep quality is poor among patients with COPD, and studies show sleep disturbance is associated with low overall quality of life in this population. We evaluated the impact of patient-reported sleep quality and sleep apnea risk on disease-specific and overall quality of life within COPD patients enrolled in the SPIROMICS study, after accounting for demographics and COPD disease severity. Methods: Baseline data from 1,341 participants [892 mild/moderate COPD (FEV1≥50% predicted); 449 severe COPD (FEV1<50%)], were used to perform three nested (blocks) regression models to predict quality of life (Short Form-12 mental and physical components and St...
March 9, 2018: Sleep
Emily P Brigham, Lyn M Steffen, Stephanie J London, Danielle Boyce, Gregory B Diette, Nadia N Hansel, Jessica Rice, Meredith C McCormack
RATIONALE: Dietary intake is a potential risk factor for respiratory morbidity in adult populations. Few studies capture the effect of diet patterns, representative of combination of nutrients consumed, on respiratory morbidity in combination with objective measures of lung function. OBJECTIVES: To evaluate patterns of dietary intake in relation to respiratory morbidity and objective measures of lung function in a U.S. POPULATION: <AbstractText Label="METHODS" NlmCategory="METHODS">The Atherosclerosis Risk in Communities (ARIC) Study enrolled 15,792 participants from four U...
February 15, 2018: Annals of the American Thoracic Society
Atul Malhotra, Alan R Schwartz, Hartmut Schneider, Robert L Owens, Pamela DeYoung, MeiLan K Han, Jadwiga A Wedzicha, Nadia N Hansel, Michelle R Zeidler, Kevin C Wilson, M Safwan Badr
BACKGROUND: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are common conditions; the co-occurrence of these diseases, called the overlap syndrome (OVS), has been associated with poor health outcomes. PURPOSE: The purpose of this Official American Thoracic Society Research Statement is to describe pathophysiology, epidemiology, outcomes, diagnostic metrics, and treatment of OVS, as well as to identify important gaps in knowledge and make recommendations for future research...
February 1, 2018: American Journal of Respiratory and Critical Care Medicine
Ashraf Fawzy, Nirupama Putcha, Laura M Paulin, Carrie P Aaron, Wassim W Labaki, MeiLan K Han, Robert A Wise, Richard E Kanner, Russell P Bowler, R Graham Barr, Nadia N Hansel
BACKGROUND: Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unknown. This study aims to determine the association of thrombocytosis with COPD morbidity including reported AECOPD, respiratory symptoms and exercise capacity. METHODS: Participants with COPD were included from two multi-center observational studies (SPIROMICS and COPDGene)...
January 26, 2018: Respiratory Research
Panagis Galiatsatos, Emily P Brigham, Juliana Pietri, Kathleen Littleton, Seungyoung Hwang, Michael C Grant, Nadia N Hansel, Edward S Chen
PURPOSE: Community factors may play a role in determining individual risk for sepsis, as well as sepsis-related morbidity and mortality. We sought to define the relationship between community socioeconomic status and mortality due to sepsis in an urban locale. METHODS: Using community statistical areas of Baltimore City, we dichotomized neighborhoods at median household income, and compared distribution of outcomes of interest within the two income categories. We performed multivariable regression analyses to determine the relationship between socioeconomic variables and sepsis-attributable mortality...
January 12, 2018: Journal of Critical Care
Benjamin M Smith, Hussein Traboulsi, John H M Austin, Ani Manichaikul, Eric A Hoffman, Eugene R Bleecker, Wellington V Cardoso, Christopher Cooper, David J Couper, Stephen M Dashnaw, Jia Guo, MeiLan K Han, Nadia N Hansel, Emlyn W Hughes, David R Jacobs, Richard E Kanner, Joel D Kaufman, Eric Kleerup, Ching-Long Lin, Kiang Liu, Christian M Lo Cascio, Fernando J Martinez, Jennifer N Nguyen, Martin R Prince, Stephen Rennard, Stephen S Rich, Leora Simon, Yanping Sun, Karol E Watson, Prescott G Woodruff, Carolyn J Baglole, R Graham Barr
Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. The most common airway branch variant is associated with COPD in two cohorts ( n = 5,054), with greater central airway bifurcation density, and with emphysema throughout the lung...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ma'en Obeidat, Xuan Li, Stephen Burgess, Guohai Zhou, Nick Fishbane, Nadia N Hansel, Yohan Bossé, Philippe Joubert, Ke Hao, David C Nickle, Maarten van den Berge, Wim Timens, Michael H Cho, Brian D Hobbs, Kim de Jong, Marike Boezen, Rayjean J Hung, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H Beaty, Kathleen C Barnes, Peter D Paré, Don D Sin
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these variants affected lung tissue gene expression in 1037 individuals. A Mendelian randomisation framework was then applied, whereby serum SP-D-associated variants were tested for association with COPD risk in 11 157 cases and 36 699 controls and with 11 years decline of lung function in the 4061 individuals...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Andrew Nicholson, Suzanne L Pollard, John J Lima, Karina M Romero, Carla Tarazona-Meza, Gary Malpartida-Guzmán, Edward Mougey, Nadia N Hansel, William Checkley
BACKGROUND: The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. METHODS: Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide...
December 2017: Respiratory Medicine
Panagis Galiatsatos, Cynthia Kineza, Seungyoun Hwang, Juliana Pietri, Emily Brigham, Nirupama Putcha, Cynthia S Rand, Meredith McCormack, Nadia N Hansel
INTRODUCTION: Several studies suggest that the health of an individual is influenced by the socioeconomic status (SES) of the community in which he or she lives. This analysis seeks to understand the relationship between SES, tobacco store density and health outcomes at the neighbourhood level in a large urban community. METHODS: Data from the 55 neighbourhoods of Baltimore City were reviewed and parametric tests compared demographics and health outcomes for low-income and high-income neighbourhoods, defined by the 50th percentile in median household income...
November 23, 2017: Tobacco Control
Annette T Hastie, Fernando J Martinez, Jeffrey L Curtis, Claire M Doerschuk, Nadia N Hansel, Stephanie Christenson, Nirupama Putcha, Victor E Ortega, Xingnan Li, R Graham Barr, Elizabeth E Carretta, David J Couper, Christopher B Cooper, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Wanda K O'Neal, Richard Paine, Stephen P Peters, Neil E Alexis, Prescott G Woodruff, MeiLan K Han, Deborah A Meyers, Eugene R Bleecker
BACKGROUND: Increased concentrations of eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with increased frequency of exacerbations, reduced lung function, and corticosteroid responsiveness. We aimed to assess whether high eosinophil concentrations in either sputum or blood are associated with a severe COPD phenotype, including greater exacerbation frequency, and whether blood eosinophils are predictive of sputum eosinophils. METHODS: We did a multicentre observational study analysing comprehensive baseline data from SPIROMICS in patients with COPD aged 40-80 years who had a smoking history of at least 20 pack-years, recruited from six clinical sites and additional subsites in the USA between Nov 12, 2010, and April 21, 2015...
December 2017: Lancet Respiratory Medicine
Jessica L Rice, Emily Brigham, Rebecca Dineen, Sadiya Muqueeth, Gena O'Keefe, Stephanie Regenold, Kirsten Koehler, Ana Rule, Meredith McCormack, Nadia N Hansel, Gregory B Diette
OBJECTIVES: Secondhand smoke (SHS) and other air pollutants adversely affect the health of pregnant women and infants. A feasibility study aimed at reducing air pollution in homes of pregnant women or infants living with a smoker was completed. METHODS: In collaboration with the Baltimore City Health Department, women ≥ 18 years of age and either pregnant nonsmokers, or post-partum (any smoking status) with an infant age 0-12 months were recruited. Homes had at least one smoker...
January 2018: Environmental Research
Nadia N Hansel, Laura M Paulin, Amanda J Gassett, Roger D Peng, Neil Alexis, Vincent S Fan, Eugene Bleecker, Russell Bowler, Alejandro P Comellas, Mark Dransfield, MeiLan K Han, Victor Kim, Jerry A Krishnan, Cheryl Pirozzi, Christopher B Cooper, Fernando Martinez, Prescott G Woodruff, Patrick J Breysse, R Graham Barr, Joel D Kaufman
INTRODUCTION: Population-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air pollutants on patient-reported outcomes, morbidity and progression of COPD. METHODS AND ANALYSIS: The Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Pollution Study (SPIROMICS AIR) was initiated in 2013 to investigate the relation between individual-level estimates of short-term and long-term air pollution exposures, day-to-day symptom variability and disease progression in individuals with COPD...
2017: BMJ Open Respiratory Research
Wayne H Anderson, Jae Wook Ha, David J Couper, Wanda K O'Neal, R Graham Barr, Eugene R Bleecker, Elizabeth E Carretta, Christopher B Cooper, Claire M Doerschuk, M Bradley Drummond, MeiLan K Han, Nadia N Hansel, Victor Kim, Eric C Kleerup, Fernando J Martinez, Stephen I Rennard, Donald Tashkin, Prescott G Woodruff, Robert Paine, Jeffrey L Curtis, Richard E Kanner
RATIONALE: Understanding the reliability and repeatability of clinical measurements used in the diagnosis, treatment and monitoring of disease progression is of critical importance across all disciplines of clinical practice and in clinical trials to assess therapeutic efficacy and safety. OBJECTIVES: Our goal is to understand normal variability for assessing true changes in health status and to more accurately utilize this data to differentiate disease characteristics and outcomes...
2017: PloS One
Carlos H Martinez, Sara X Li, Andrew J Hirzel, Valerie R Stolberg, Neil E Alexis, R Graham Barr, Eugene R Bleecker, Elizabeth E Carretta, Stephanie A Christenson, Christopher B Cooper, David J Couper, Claire M Doerschuk, MeiLan K Han, Nadia N Hansel, Annette T Hastie, Eric A Hoffman, Robert J Kaner, Fernando J Martinez, Deborah A Meyers, Wanda K O'Neal, Robert Paine, Nirupama Putcha, Stephen I Rennard, Prescott G Woodruff, Michelle Zeidler, Jeffrey L Curtis, Christine M Freeman
No abstract text is available yet for this article.
September 12, 2017: Journal of Allergy and Clinical Immunology
Benedicta Nneoma Nnodum, Meredith C McCormack, Nirupama Putcha, Seungyoung Hwang, Laura M Paulin, Emily P Brigham, Ashraf Fawzy, Karina Romero, Gregory B Diette, Nadia N Hansel
This study aims to determine the impact of physical activity on asthma symptom reporting among children living in an inner city. Among 147 children aged 5-12 years with physician-diagnosed asthma, we assessed asthma symptoms using twice-daily diaries and physical activity using the physical activity questionnaire for children during three 8-day periods (baseline, 3 and 6 months). Linear, logistic, and quasi-poisson regression models were used to determine the association between physical activity and asthma symptoms; adjusting for age, sex, race, BMI, caregiver's education, asthma severity, medication use, and season...
December 2017: Lung
Russell P Bowler, Nadia N Hansel, Sean Jacobson, R Graham Barr, Barry J Make, MeiLan K Han, Wanda K O'Neal, Elizabeth C Oelsner, Richard Casaburi, Igor Barjaktarevic, Chris Cooper, Marilyn Foreman, Robert A Wise, Dawn L DeMeo, Edwin K Silverman, William Bailey, Kathleen F Harrington, Prescott G Woodruff, M Bradley Drummond
BACKGROUND: Electronic cigarettes (e-cigarettes) are battery-operated nicotine-delivery devices used by some smokers as a cessation tool as well as by never smokers. OBJECTIVE: To determine the usage of e-cigarettes in older adults at risk for or with chronic obstructive pulmonary disease (COPD). DESIGN: Prospective cohorts. PARTICIPANTS: COPDGene (N = 3536) and SPIROMICS (N = 1060) subjects who were current or former smokers aged 45-80...
December 2017: Journal of General Internal Medicine
Mehmet Kesimer, Amina A Ford, Agathe Ceppe, Giorgia Radicioni, Rui Cao, C William Davis, Claire M Doerschuk, Neil E Alexis, Wayne H Anderson, Ashley G Henderson, R Graham Barr, Eugene R Bleecker, Stephanie A Christenson, Christopher B Cooper, MeiLan K Han, Nadia N Hansel, Annette T Hastie, Eric A Hoffman, Richard E Kanner, Fernando Martinez, Robert Paine, Prescott G Woodruff, Wanda K O'Neal, Richard C Boucher
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitic and emphysematous components. In one biophysical model, the concentration of mucin on the airway surfaces is hypothesized to be a key variable that controls mucus transport in healthy persons versus cessation of transport in persons with muco-obstructive lung diseases. Under this model, it is postulated that a high mucin concentration produces the sputum and disease progression that are characteristic of chronic bronchitis...
September 7, 2017: New England Journal of Medicine
Laura M Paulin, D 'Ann L Williams, Roger Peng, Gregory B Diette, Meredith C McCormack, Patrick Breysse, Nadia N Hansel
Exposure to nitrogen dioxide (NO2), a byproduct of combustion, is associated with poor asthma control in children. We sought to determine whether gas-fueled kitchen appliance use is associated with 24-h indoor NO2 concentrations and whether these concentrations are associated with asthma morbidity in children. Children aged 5-12 years old with asthma were eligible. Mean 24-h NO2 concentration was measured in the kitchen over a four-day sampling period and gas stove use was captured in time activity diaries...
November 2017: Environmental Research
Emily P Brigham, Elizabeth C Matsui, Lawrence J Appel, Deborah A Bull, Jean Curtin-Brosnan, Shuyan Zhai, Karen White, Jeanne B Charleston, Nadia N Hansel, Gregory B Diette, Meredith C McCormack
RATIONALE: Evidence from observational studies and to a lesser extent clinical trials suggest that a healthy diet may improve symptoms and lung function in patients with asthma. We conducted a pilot study to determine the feasibility of conducting a larger scale dietary trial and to provide preliminary evidence on the impact of a healthy diet on asthma outcomes. METHODS: In a randomized, two period cross-over trial, participants with asthma received a 4-week dietary intervention followed by a usual diet (or vice versa), separated by a 4-week washout...
2017: PloS One
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