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https://www.readbyqxmd.com/read/28533007/free-25-oh-d-concentrations-are-associated-with-atopy-and-lung-function-in-children-with-asthma
#1
Suzanne L Pollard, John J Lima, Edward Mougey, Karina Romero, Carla Tarazona-Meza, Katherine Tomaino, Gary Malpartida Guzmán, Nadia N Hansel, William Checkley
BACKGROUND: Evidence suggests free mono-hydroxyvitamin D (25[OH]D) concentrations are more strongly linked to certain outcomes than total concentrations; however, no studies have examined the relation between free 25(OH)D and respiratory or allergic disease. OBJECTIVE: To examine associations between total and free 25(OH)D concentrations and asthma outcomes. METHODS: We quantified total and free 25(OH)D concentrations in 137 Peruvian children with asthma and 152 children without asthma and examined associations with asthma outcomes...
May 19, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28459622/respiratory-symptoms-items-from-the-copd-assessment-test-identify-ever-smokers-with-preserved-lung-function-at-higher-risk-for-poor-respiratory-outcomes-an-analysis-of-the-subpopulations-and-intermediate-outcome-measures-in-copd-study-cohort
#2
Carlos H Martinez, Susan Murray, R Graham Barr, Eugene Bleecker, Russell P Bowler, Stephanie A Christenson, Alejandro P Comellas, Christopher B Cooper, David Couper, Gerard J Criner, Jeffrey L Curtis, Mark T Dransfield, Nadia N Hansel, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Jerry A Krishnan, Stephen C Lazarus, Nancy K Leidy, Wanda O'Neal, Fernando J Martinez, Robert Paine, Stephen I Rennard, Donald P Tashkin, Prescott G Woodruff, MeiLan K Han
RATIONALE: Ever-smokers without airflow obstruction scores greater than or equal to 10 on the COPD Assessment Test (CAT) still have frequent acute respiratory disease events (exacerbation-like), impaired exercise capacity, and imaging abnormalities. Identification of these subjects could provide new opportunities for targeted interventions. OBJECTIVES: We hypothesized that the four respiratory-related items of the CAT might be useful for identifying such individuals, with discriminative ability similar to CAT, which is an eight-item questionnaire used to assess chronic obstructive pulmonary disease impact, including nonrespiratory questions, with scores ranging from 0 to 40...
May 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28424616/whole-blood-cytokine-response-to-local-traffic-related-particulate-matter-in-peruvian-children-with-and-without-asthma
#3
Jesse P Negherbon, Karina Romero, D'Ann L Williams, Rafael E Guerrero-Preston, Thomas Hartung, Alan L Scott, Patrick N Breysse, William Checkley, Nadia N Hansel
This study sought to investigate if acute phase immune responses of whole blood from Peruvian children with controlled and uncontrolled asthma differed from children without asthma, following exposure to traffic-related particulate matter (TRPM). TRPM, including particulate matter from diesel combustion, has been shown to stimulate acute airway inflammation in individuals with and without asthma. For this study, a whole blood assay (WBA) was used to test peripheral whole blood samples from 27 children with asthma, and 12 without asthma...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28174340/genetic-variants-affecting-cross-sectional-lung-function-in-adults-show-little-or-no-effect-on-longitudinal-lung-function-decline
#4
Catherine John, María Soler Artigas, Jennie Hui, Sune Fallgaard Nielsen, Nicholas Rafaels, Peter D Paré, Nadia N Hansel, Nick Shrine, Iain Kilty, Anders Malarstig, Scott A Jelinsky, Signe Vedel-Krogh, Kathleen Barnes, Ian P Hall, John Beilby, Arthur W Musk, Børge G Nordestgaard, Alan James, Louise V Wain, Martin D Tobin
BACKGROUND: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be defined. OBJECTIVES: We aimed to determine whether regions associated with cross-sectional lung function were also associated with longitudinal decline and to seek novel variants which influence decline. METHODS: We analysed genome-wide data from 4167 individuals from the Busselton Health Study cohort, who had undergone spirometry (12 695 observations across eight time points)...
February 7, 2017: Thorax
https://www.readbyqxmd.com/read/28166213/genome-wide-association-analyses-for-lung-function-and-chronic-obstructive-pulmonary-disease-identify-new-loci-and-potential-druggable-targets
#5
Louise V Wain, Nick Shrine, María Soler Artigas, A Mesut Erzurumluoglu, Boris Noyvert, Lara Bossini-Castillo, Ma'en Obeidat, Amanda P Henry, Michael A Portelli, Robert J Hall, Charlotte K Billington, Tracy L Rimington, Anthony G Fenech, Catherine John, Tineka Blake, Victoria E Jackson, Richard J Allen, Bram P Prins, Archie Campbell, David J Porteous, Marjo-Riitta Jarvelin, Matthias Wielscher, Alan L James, Jennie Hui, Nicholas J Wareham, Jing Hua Zhao, James F Wilson, Peter K Joshi, Beate Stubbe, Rajesh Rawal, Holger Schulz, Medea Imboden, Nicole M Probst-Hensch, Stefan Karrasch, Christian Gieger, Ian J Deary, Sarah E Harris, Jonathan Marten, Igor Rudan, Stefan Enroth, Ulf Gyllensten, Shona M Kerr, Ozren Polasek, Mika Kähönen, Ida Surakka, Veronique Vitart, Caroline Hayward, Terho Lehtimäki, Olli T Raitakari, David M Evans, A John Henderson, Craig E Pennell, Carol A Wang, Peter D Sly, Emily S Wan, Robert Busch, Brian D Hobbs, Augusto A Litonjua, David W Sparrow, Amund Gulsvik, Per S Bakke, James D Crapo, Terri H Beaty, Nadia N Hansel, Rasika A Mathias, Ingo Ruczinski, Kathleen C Barnes, Yohan Bossé, Philippe Joubert, Maarten van den Berge, Corry-Anke Brandsma, Peter D Paré, Don D Sin, David C Nickle, Ke Hao, Omri Gottesman, Frederick E Dewey, Shannon E Bruse, David J Carey, H Lester Kirchner, Stefan Jonsson, Gudmar Thorleifsson, Ingileif Jonsdottir, Thorarinn Gislason, Kari Stefansson, Claudia Schurmann, Girish Nadkarni, Erwin P Bottinger, Ruth J F Loos, Robin G Walters, Zhengming Chen, Iona Y Millwood, Julien Vaucher, Om P Kurmi, Liming Li, Anna L Hansell, Chris Brightling, Eleftheria Zeggini, Michael H Cho, Edwin K Silverman, Ian Sayers, Gosia Trynka, Andrew P Morris, David P Strachan, Ian P Hall, Martin D Tobin
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1...
March 2017: Nature Genetics
https://www.readbyqxmd.com/read/27966668/predictors-of-polycyclic-aromatic-hydrocarbon-exposure-and-internal-dose-in-inner-city-baltimore-children
#6
Kamau O Peters, D' Ann L Williams, Salahadin Abubaker, Jean Curtin-Brosnan, Meredith C McCormack, Roger Peng, Patrick N Breysse, Elizabeth C Matsui, Nadia N Hansel, Gregory B Diette, Paul T Strickland
Polycyclic aromatic hydrocarbons (PAHs), the by-products of incomplete combustion of organic materials, are commonly found on particulate matter (PM) and have been associated with the development of asthma and asthma exacerbation in urban populations. We examined time spent in the home and outdoors as predictors of exposures to airborne PAHs and measured urinary 1-hydroxypyrene-glucuronide (1-OHPG) as internal dose of PAHs in 118 children aged 5-12 years from Baltimore, MD. During weeklong periods (Saturday-Saturday) in each of four seasons: daily activities were assessed using questionnaires, indoor air nicotine and PM concentrations were monitored, and urine specimens were collected on Tuesday (day 3) and Saturday (day 7) for measurement of 1-OHPG...
May 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27888993/identifying-biomarkers-for-asthma-diagnosis-using-targeted-metabolomics-approaches
#7
William Checkley, Maria P Deza, Jost Klawitter, Karina M Romero, Jelena Klawitter, Suzanne L Pollard, Robert A Wise, Uwe Christians, Nadia N Hansel
BACKGROUND: The diagnosis of asthma in children is challenging and relies on a combination of clinical factors and biomarkers including methacholine challenge, lung function, bronchodilator responsiveness, and presence of airway inflammation. No single test is diagnostic. We sought to identify a pattern of inflammatory biomarkers that was unique to asthma using a targeted metabolomics approach combined with data science methods. METHODS: We conducted a nested case-control study of 100 children living in a peri-urban community in Lima, Peru...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27725671/a-continuum-of-admixture-in-the-western-hemisphere-revealed-by-the-african-diaspora-genome
#8
Rasika Ann Mathias, Margaret A Taub, Christopher R Gignoux, Wenqing Fu, Shaila Musharoff, Timothy D O'Connor, Candelaria Vergara, Dara G Torgerson, Maria Pino-Yanes, Suyash S Shringarpure, Lili Huang, Nicholas Rafaels, Meher Preethi Boorgula, Henry Richard Johnston, Victor E Ortega, Albert M Levin, Wei Song, Raul Torres, Badri Padhukasahasram, Celeste Eng, Delmy-Aracely Mejia-Mejia, Trevor Ferguson, Zhaohui S Qin, Alan F Scott, Maria Yazdanbakhsh, James G Wilson, Javier Marrugo, Leslie A Lange, Rajesh Kumar, Pedro C Avila, L Keoki Williams, Harold Watson, Lorraine B Ware, Christopher Olopade, Olufunmilayo Olopade, Ricardo Oliveira, Carole Ober, Dan L Nicolae, Deborah Meyers, Alvaro Mayorga, Jennifer Knight-Madden, Tina Hartert, Nadia N Hansel, Marilyn G Foreman, Jean G Ford, Mezbah U Faruque, Georgia M Dunston, Luis Caraballo, Esteban G Burchard, Eugene Bleecker, Maria Ilma Araujo, Edwin Francisco Herrera-Paz, Kimberly Gietzen, Wendy E Grus, Michael Bamshad, Carlos D Bustamante, Eimear E Kenny, Ryan D Hernandez, Terri H Beaty, Ingo Ruczinski, Joshua Akey, Kathleen C Barnes
The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas...
October 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27689704/physical-activity-and-air-pollution-exposures-in-the-urban-environment
#9
Laura M Paulin, Nadia N Hansel
No abstract text is available yet for this article.
October 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27684429/respiratory-effects-of-indoor-heat-and-the-interaction-with-air-pollution-in-chronic-obstructive-pulmonary-disease
#10
Meredith C McCormack, Andrew J Belli, Darryn Waugh, Elizabeth C Matsui, Roger D Peng, D'Ann L Williams, Laura Paulin, Anik Saha, Charles M Aloe, Gregory B Diette, Patrick N Breysse, Nadia N Hansel
RATIONALE: There is limited evidence of the effect of exposure to heat on chronic obstructive pulmonary disease (COPD) morbidity, and the interactive effect between indoor heat and air pollution has not been established. OBJECTIVES: To determine the effect of indoor and outdoor heat exposure on COPD morbidity and to determine whether air pollution concentrations modify the effect of temperature. METHODS: Sixty-nine participants with COPD were enrolled in a longitudinal cohort study, and data from the 601 participant days that occurred during the warm weather season were included in the analysis...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27579823/biomarkers-predictive-of-exacerbations-in-the-spiromics-and-copdgene-cohorts
#11
Jason D Keene, Sean Jacobson, Katerina Kechris, Gregory L Kinney, Marilyn G Foreman, Claire M Doerschuk, Barry J Make, Jeffrey L Curtis, Stephen I Rennard, R Graham Barr, Eugene R Bleecker, Richard E Kanner, Eric C Kleerup, Nadia N Hansel, Prescott G Woodruff, MeiLan K Han, Robert Paine, Fernando J Martinez, Russell P Bowler, Wanda K O'Neal
RATIONALE: Chronic obstructive pulmonary disease exacerbations are associated with disease progression, higher healthcare cost, and increased mortality. Published predictors of future exacerbations include previous exacerbation, airflow obstruction, poor overall health, home oxygen use, and gastroesophageal reflux. OBJECTIVES: To determine the value of adding blood biomarkers to clinical variables to predict exacerbations. METHODS: Subjects from the SPIROMICS (Subpopulations and Intermediate Outcomes Measures in COPD Study) (n = 1,544) and COPDGene (Genetic Epidemiology of COPD) (n = 602) cohorts had 90 plasma or serum candidate proteins measured on study entry using Myriad-RBM multiplex panels...
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27568229/obesity-is-associated-with-increased-morbidity-in-moderate-to-severe-copd
#12
MULTICENTER STUDY
Allison A Lambert, Nirupama Putcha, M Bradley Drummond, Aladin M Boriek, Nicola A Hanania, Victor Kim, Gregory L Kinney, Merry-Lynn N McDonald, Emily P Brigham, Robert A Wise, Meredith C McCormack, Nadia N Hansel
BACKGROUND: Obesity is prevalent in the United States; however, the impact of obesity on COPD morbidity is unclear. We hypothesized that obesity is associated with worse outcomes in COPD. METHODS: We examined 3,631 participants from the multicenter prospective cohort study Genetic Epidemiology of COPD (COPDGene) who had spirometry-confirmed COPD, a postbronchodilator FEV1 < 80% predicted, and a BMI ≥ 18.5 kg/m(2). We conducted logistic and linear regression analyses to determine the association between COPD outcomes and obesity class, adjusting for relevant confounders...
January 2017: Chest
https://www.readbyqxmd.com/read/27564413/age-and-small-airway-imaging-abnormalities-in-subjects-with-and-without-airflow-obstruction-in-spiromics
#13
Carlos H Martinez, Alejandro A Diaz, Catherine Meldrum, Jeffrey L Curtis, Christopher B Cooper, Cheryl Pirozzi, Richard E Kanner, Robert Paine, Prescott G Woodruff, Eugene R Bleecker, Nadia N Hansel, R Graham Barr, Nathaniel Marchetti, Gerard J Criner, Ella A Kazerooni, Eric A Hoffman, Brian D Ross, Craig J Galban, Christine T Cigolle, Fernando J Martinez, MeiLan K Han
RATIONALE: Aging is associated with reduced FEV1 to FVC ratio (FEV1/FVC), hyperinflation, and alveolar enlargement, but little is known about how age affects small airways. OBJECTIVES: To determine if chest computed tomography (CT)-assessed functional small airway would increase with age, even among asymptomatic individuals. METHODS: We used parametric response mapping analysis of paired inspiratory/expiratory CTs to identify functional small airway abnormality (PRM(FSA)) and emphysema (PRM(EMPH)) in the SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study) cohort...
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27532455/common-genetic-polymorphisms-influence-blood-biomarker-measurements-in-copd
#14
Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-Huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O'Neal, Russell P Bowler
Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental variations contribute to phenotypic diversity and disease progression. A meta-analysis from two large cohorts of current and former smokers with and without COPD [SPIROMICS (N = 750); COPDGene (N = 590)] was used to identify single nucleotide polymorphisms (SNPs) associated with measurement of 88 blood proteins (protein quantitative trait loci; pQTLs)...
August 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27482984/spiromics-protocol-for-multicenter-quantitative-computed-tomography-to-phenotype-the-lungs
#15
Jered P Sieren, John D Newell, R Graham Barr, Eugene R Bleecker, Nathan Burnette, Elizabeth E Carretta, David Couper, Jonathan Goldin, Junfeng Guo, MeiLan K Han, Nadia N Hansel, Richard E Kanner, Ella A Kazerooni, Fernando J Martinez, Stephen Rennard, Prescott G Woodruff, Eric A Hoffman
Multidetector row computed tomography (MDCT) is increasingly taking a central role in identifying subphenotypes within chronic obstructive pulmonary disease (COPD), asthma, and other lung-related disease populations, allowing for the quantification of the amount and distribution of altered parenchyma along with the characterization of airway and vascular anatomy. The embedding of quantitative CT (QCT) into a multicenter trial with a variety of scanner makes and models along with the variety of pressures within a clinical radiology setting has proven challenging, especially in the context of a longitudinal study...
October 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27372063/indoor-particulate-matter-exposure-is-associated-with-increased-black-carbon-content-in-airway-macrophages-of-former-smokers-with-copd
#16
Andrew J Belli, Sonali Bose, Neil Aggarwal, Christopher DaSilva, Sritika Thapa, Laura Grammer, Laura M Paulin, Nadia N Hansel
INTRODUCTION: Exposure to fine particulate matter (PM2.5) is associated with worse morbidity in individuals with COPD. Inhaled PM is phagocytosed by airway macrophages (AM), and black carbon measured in AM may serve as a biomarker of air pollution exposure. As there is little data on how indoor PM exposure may influence AM black carbon content in those with respiratory disease, we investigated the association of indoor PM2.5 concentration to AM black carbon content in adults with COPD...
October 2016: Environmental Research
https://www.readbyqxmd.com/read/27168432/clinical-significance-of-symptoms-in-smokers-with-preserved-pulmonary-function
#17
MULTICENTER STUDY
Prescott G Woodruff, R Graham Barr, Eugene Bleecker, Stephanie A Christenson, David Couper, Jeffrey L Curtis, Natalia A Gouskova, Nadia N Hansel, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Stephen C Lazarus, Fernando J Martinez, Robert Paine, Stephen Rennard, Donald P Tashkin, MeiLan K Han
BACKGROUND: Currently, the diagnosis of chronic obstructive pulmonary disease (COPD) requires a ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) of less than 0.70 as assessed by spirometry after bronchodilator use. However, many smokers who do not meet this definition have respiratory symptoms. METHODS: We conducted an observational study involving 2736 current or former smokers and controls who had never smoked and measured their respiratory symptoms using the COPD Assessment Test (CAT; scores range from 0 to 40, with higher scores indicating greater severity of symptoms)...
May 12, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27059393/outpatient-measurement-of-arterial-stiffness-in-patients-with-type-2-diabetes-and-obesity
#18
Kamel Mohammedi, Aminata Compaoré, Louis Potier, Narimène Belhatem, Marilyne Feron, Nadia Matallah, Florence Travert, Boris Hansel, Gilberto Velho, Ronan Roussel, Magid Hallab, Michel Marre
BACKGROUND: Pulse wave velocity (PWV) is a marker of arterial stiffness. The aim of the present study was to compare PWV in patients with type 2 diabetes mellitus (T2DM) or obesity and healthy subjects in an outpatient setting. METHODS: A cross-sectional study was conducted in patients with obesity without T2DM (n = 37), T2DM without obesity (n = 40), T2DM plus obesity (n = 43), and healthy controls (n = 114). Outpatient measurements of the finger-toe PWV (ftPWV) were made...
April 5, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/26962445/particulate-air-pollution-and-impaired-lung-function
#19
REVIEW
Laura Paulin, Nadia Hansel
Air pollution is a leading cause of morbidity and mortality throughout the world, particularly in individuals with existing lung disease. Of the most common air pollutants, particulate matter (PM) is associated with an increased risk of exacerbations and respiratory symptoms in individuals with existing lung disease, and to a lesser extent, in those without known respiratory issues. The majority of published research has focused on the effects of PM exposures on symptoms and health care utilization. Fewer studies focus on the impact of PM on objective measurements of pulmonary function...
2016: F1000Research
https://www.readbyqxmd.com/read/26962015/understanding-the-impact-of-second-hand-smoke-exposure-on-clinical-outcomes-in-participants-with-copd-in-the-spiromics-cohort
#20
Nirupama Putcha, R Graham Barr, Meilan K Han, Prescott G Woodruff, Eugene R Bleecker, Richard E Kanner, Fernando J Martinez, Benjamin M Smith, Donald P Tashkin, Russell P Bowler, Mark D Eisner, Stephen I Rennard, Robert A Wise, Nadia N Hansel
BACKGROUND: Second-hand smoke (SHS) exposure has been linked to the development of and morbidity from lung disease. We sought to advance understanding of the impact of SHS on health-related outcomes in individuals with COPD. METHODS: Among the participants with COPD in SPIROMICS, recent SHS exposure was quantified as (1) hours of reported exposure in the past week or (2) reported living with a smoker. We performed adjusted regression for SHS with outcomes, testing for interactions with gender, race, smoking and obesity...
March 9, 2016: Thorax
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