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Allergy prevention

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https://www.readbyqxmd.com/read/28444082/ii-brazilian-consensus-on-the-use-of-human-immunoglobulin-in-patients-with-primary-immunodeficiencies
#1
Ekaterini Simões Goudouris, Almerinda Maria do Rego Silva, Aluce Loureiro Ouricuri, Anete Sevciovic Grumach, Antonio Condino-Neto, Beatriz Tavares Costa-Carvalho, Carolina Cardoso de Mello Prando, Cristina Maria Kokron, Dewton de Moraes Vasconcelos, Fabíola Scancetti Tavares, Gesmar Rodrigues Silva Segundo, Irma Cecília Douglas Paes Barreto, Mayra de Barros Dorna, Myrthes Anna Maragna Toledo Barros, Wilma Carvalho Neves Forte
In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010...
2017: Einstein
https://www.readbyqxmd.com/read/28437767/building-integrated-agriculture-a-first-assessment-of-aerobiological-air-quality-in-rooftop-greenhouses-i-rtgs
#2
Mireia Ercilla-Montserrat, Rebeca Izquierdo, Jordina Belmonte, Juan Ignacio Montero, Pere Muñoz, Concepción De Linares, Joan Rieradevall
Building-integrated rooftop greenhouse (i-RTG) agriculture has intensified in recent years, due to the growing interest in the development of new agricultural spaces and in the promotion of food self-sufficiency in urban areas. This paper provides a first assessment of the indoor dynamics of bioaerosols in an i-RTG, with the aim of evaluating biological air quality in a tomato greenhouse near Barcelona. It evaluates the greenhouse workers' exposure to airborne pollen and fungal spores in order to prevent allergy problems associated with occupational tasks...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28431923/sources-of-racial-disparities-in-hiv-prevalence-in-men-who-have-sex-with-men-in-atlanta-ga-usa-a-modelling-study
#3
Steven M Goodreau, Eli S Rosenberg, Samuel M Jenness, Nicole Luisi, Sarah E Stansfield, Gregorio A Millett, Patrick S Sullivan
BACKGROUND: In the USA, men who have sex men (MSM) are at high risk for HIV, and black MSM have a substantially higher prevalence of infection than white MSM. We created a simulation model to assess the strength of existing hypotheses and data that account for these disparities. METHODS: We built a dynamic, stochastic, agent-based network model of black and white MSM aged 18-39 years in Atlanta, GA, USA, that incorporated race-specific individual and dyadic-level prevention and risk behaviours, network attributes, and care patterns...
April 18, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28429306/mitochondrial-function-in-allergic-disease
#4
REVIEW
Divyaanka Iyer, Navya Mishra, Anurag Agrawal
PURPOSE OF THE REVIEW: The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function and its importance in allergy and asthma. We briefly also consider the potential of mitochondria-targeted therapies in prevention and cure...
May 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28429303/natural-evolution-of-ige-responses-to-mite-allergens-and-relationship-to-progression-of-allergic-disease-a-review
#5
REVIEW
Daniela Posa, Stephanie Hofmaier, Stefania Arasi, Paolo Maria Matricardi
PURPOSE OF REVIEW: Allergenic molecules of the house dust mite (HDM) are crucially important indoor allergens, contributing to allergic rhinitis and asthma around the globe. In the past years, recombinant molecules for diagnostics opened new pathways to investigate individual sensitization profiles and new chances for the prevention and treatment of HDM allergy. This review summarizes the latest findings on the evolution of IgE responses towards mite allergens. RECENT FINDINGS: Several cross-sectional and longitudinal studies confirmed the role of Der p 1 and Der p 2 as major allergenic proteins of the HDM...
May 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28423486/tick-host-conflict-immunoglobulin-e-antibodies-to-tick-proteins-in-patients-with-anaphylaxis-to-tick-bite
#6
Lourdes Mateos-Hernández, Margarita Villar, Angel Moral, Carmen García Rodríguez, Teresa Alfaya Arias, Verónica de la Osa, Francisco Feo Brito, Isabel G Fernández de Mera, Pilar Alberdi, Francisco Ruiz-Fons, Alejandro Cabezas-Cruz, Agustín Estrada-Peña, José de la Fuente
Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate α-Gal (Gal α 1-3Gal β 1-(3)4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. To address this question, a comparative proteomics approach was used to characterize tick proteins producing an IgE antibody response in a healthy individual with record of tick bites, which had not resulted in any allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus bursa or Hyalomma marginatum tick bites...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421513/primary-prevention-of-food-allergy
#7
REVIEW
Matthew J Greenhawt, David M Fleischer
Food allergy is estimated to affect approximately 8% of children in the USA. This is a disease without any known treatment or cure and, for some, a disease that can be quite severe, even life-threatening. While recent advances in potential treatment have made remarkable strides, with two food-targeted immunotherapy products now in phase III trials, perhaps the biggest gains in the field have come in the advent of potential preventative strategies to avoid the development of food allergy in high-risk individuals...
April 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28410406/lubiprostone-improves-intestinal-permeability-in-humans-a-novel-therapy-for-the-leaky-gut-a-prospective-randomized-pilot-study-in-healthy-volunteers
#8
RANDOMIZED CONTROLLED TRIAL
Takayuki Kato, Yasushi Honda, Yusuke Kurita, Akito Iwasaki, Takamitsu Sato, Takaomi Kessoku, Shiori Uchiyama, Yuji Ogawa, Hidenori Ohkubo, Takuma Higurashi, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Atsushi Nakajima
BACKGROUND AND AIMS: The barrier function of the small intestinal mucosa prevents the introduction of undesired pathogens into the body. Breakdown of this barrier function increases intestinal permeability. This has been proposed to induce not only gastrointestinal diseases, including inflammatory bowel disease and irritable bowel syndrome, but also various other diseases, including allergies, diabetes mellitus, liver diseases, and collagen diseases, which are associated with this so called "leaky gut syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/28410085/early-solid-food-introduction-role-in-food-allergy-prevention-and-implications-for-breastfeeding
#9
Elissa M Abrams, Matthew Greenhawt, David M Fleischer, Edmond S Chan
No abstract text is available yet for this article.
May 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28406434/preventive-effects-of-heat-killed-enterococcus-faecalis-strain-ec-12-on-mouse-intestinal-tumor-development
#10
Shingo Miyamoto, Masami Komiya, Gen Fujii, Takahiro Hamoya, Ruri Nakanishi, Kyoko Fujimoto, Shuya Tamura, Yurie Kurokawa, Maiko Takahashi, Tetsuo Ijichi, Michihiro Mutoh
Establishing effective methods for preventing colorectal cancer by so-called "functional foods" is important because the global burden of colorectal cancer is increasing. Enterococcus faecalis strain EC-12 (EC-12), which belongs to the family of lactic acid bacteria, has been shown to exert pleiotropic effects, such as anti-allergy and anti-infectious effects, on mammalian cells. In the present study, we aimed to evaluate the preventive effects of heat-killed EC-12 on intestinal carcinogenesis. We fed 5-week-old male and female Apc mutant Min mice diets containing 50 or 100 ppm heat-killed EC-12 for 8 weeks...
April 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28394404/comparing-immediate-type-food-allergy-in-humans-and-companion-animals-revealing-unmet-needs
#11
I Pali-Schöll, M De Lucia, H Jackson, J Janda, R S Mueller, E Jensen-Jarolim
Adverse food reactions occur in human as well as veterinary patients and systematic comparison may lead to improved recommendations for prevention and treatment in both. In this position paper, we summarize the current knowledge on immediate type food allergy versus other food-adverse reactions in companion animals, and compare this to the human situation. While the prevalence of food allergy in humans has been well studied for some allergens, this remains to be investigated for animal patients, where owner-reported as well as veterinarian-diagnosed food adverse reactions are on the increase...
April 10, 2017: Allergy
https://www.readbyqxmd.com/read/28392808/consumer-preferences-for-food-allergen-labeling
#12
Carlo A Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott, Larry D Lynd
BACKGROUND: Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) and subsequent update (2012) suggesting that research is needed to guide further iterations of the regulation to improve food allergen labeling and reduce risk of exposure. OBJECTIVE: The primary objective of this study was to examine consumer preferences in food labeling for allergy avoidance and anaphylaxis prevention...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28390860/basophil-derived-interleukin-4-promotes-epicutaneous-antigen-sensitization-concomitant-with-the-development-of-food-allergy
#13
Maryam Hussain, Loïc Borcard, Kevin P Walsh, Maria Pena Rodriguez, Christoph Mueller, Brian S Kim, Masato Kubo, David Artis, Mario Noti
BACKGROUND: Exaggerated TSLP production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. While TSLP and basophils have been implicated to promote food-induced allergic disorders in response to epicutaneous sensitization, the mechanisms by which TSLP-elicited basophils guide the progression of allergic inflammation in the skin to distant mucosal sites such as the gastrointestinal tract are poorly understood...
April 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28390578/preventing-food-allergies-with-tweaks-to-the-infant-diet-a-practical-reality
#14
Julie Wang, Marion Groetch
No abstract text is available yet for this article.
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28389323/an-approach-to-allergy-risk-assessments-for-e-liquid-ingredients
#15
Sandra Costigan, Juan Lopez-Belmonte
Many flavours and fragrances are known allergens. Their selection and inclusion levels in e-liquids must therefore be guided by toxicological principles, taking into account the exposure pattern and inhalation route of exposure. For contact sensitisation, a general, agreed quantitative risk assessment approach to prevent dermal sensitisation exists. Here we propose exposure parameters and safety factors to apply this approach to e-liquid ingredients. Additionally, as a risk management approach for pre-sensitised individuals, we derive a threshold of 0...
April 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28389303/anaphylaxis-in-the-pediatric-emergency-department-analysis-of-133-cases-after-an-allergy-workup
#16
Alberto Alvarez-Perea, Beatriz Ameiro, Cristina Morales, Gabriela Zambrano, Ana Rodríguez, Miguel Guzmán, José Manuel Zubeldia, María L Baeza
BACKGROUND: Data on the incidence and characteristics of pediatric anaphylaxis are scarce. Reported causes of anaphylaxis are mostly those suspected by the physician in the emergency department (ED), which may not coincide with the real triggers. OBJECTIVES: To investigate the incidence, management, and etiology of pediatric anaphylaxis in the ED of a Spanish tertiary hospital and to determine the concordance between the suspected etiology in the ED and diagnosis after the allergy workup...
April 4, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28389302/allergen-specific-immunotherapy-for-respiratory-allergy-in-children-unmet-needs-and-future-goals
#17
Pasquale Comberiati, Gian Luigi Marseglia, Salvatore Barberi, Giovanni Passalacqua, Diego G Peroni
Allergen-specific immunotherapy for the treatment of respiratory allergy is currently supported, at least for selected products, by evidence of efficacy and effectiveness in the pediatric age. However, unmet needs remain in terms of administration regimens, duration of treatment, biomarkers, and preventive effects. These knowledge gaps need to be urgently addressed to provide pediatricians and pediatric allergists with more definite recommendations for the use of this treatment in children. This article critically appraises the most relevant debated issues on allergen-specific immunotherapy in children, focusing on allergen standardization procedures, heterogeneity of clinical studies, and regulatory and pharmacoeconomic aspects...
April 4, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28383398/effect-of-probiotics-on-digestibility-and-immunity-in-infants-a-study-protocol-for-a-randomized-controlled-trial
#18
Lingli Xiao, Guodong Ding, Yifang Ding, Chaoming Deng, Xiaolei Ze, Liang Chen, Yao Zhang, Lihua Song, Hongli Yan, Fang Liu, Xiaoming Ben
The gastrointestinal (GI) tract of a fetus in utero is sterile but it becomes colonized with environmental microorganisms shortly after birth. Since the gut microbiota undergoes substantial changes in early life, healthy gut microflora is essential to an infant's gut health and immune system and probably also has an effect on overall health status in later life. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although randomized controlled trials using probiotics in infants have shown promising results in the prevention and treatment of common diseases such as diarrhea and allergy, little is known about whether probiotics could offer benefits to healthy infants...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28379454/intervention-strategies-for-cesarean-section-induced-alterations-in-the-microbiota-gut-brain-axis
#19
Angela Moya-Pérez, Pauline Luczynski, Ingrid B Renes, Shugui Wang, Yuliya Borre, C Anthony Ryan, Jan Knol, Catherine Stanton, Timothy G Dinan, John F Cryan
Microbial colonization of the gastrointestinal tract is an essential process that modulates host physiology and immunity. Recently, researchers have begun to understand how and when these microorganisms colonize the gut and the early-life factors that impact their natural ecological establishment. The vertical transmission of maternal microbes to the offspring is a critical factor for host immune and metabolic development. Increasing evidence also points to a role in the wiring of the gut-brain axis. This process may be altered by various factors such as mode of delivery, gestational age at birth, the use of antibiotics in early life, infant feeding, and hygiene practices...
April 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28377171/benefits-of-subspecialty-adherence-after-asthma-hospitalization-and-patient-perceived-barriers-to-care
#20
Neema Izadi, Jonathan S Tam
BACKGROUND: Comparative studies have demonstrated that asthma education to pediatric patients decreases average hospital usage and that allergy specialists provide stronger asthma education and more improved outcomes. OBJECTIVE: To evaluate the real-world benefits of allergy subspecialty involvement outside inpatient consultation and the impediments for patients in establishing allergy subspecialty care. METHODS: The study population was composed mostly of minority children 0 to 18 years old seen at a large university-affiliated stand-alone children's hospital who had a hospital discharge diagnosis of asthma from 2009 to 2013...
April 1, 2017: Annals of Allergy, Asthma & Immunology
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