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Allergy prevention

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https://www.readbyqxmd.com/read/29350763/molecular-allergen-profiling-in-horses-by-microarray-reveals-fag-e-2-from-buckwheat-as-a-frequent-sensitizer
#1
L Einhorn, G Hofstetter, S Brandt, E K Hainisch, I Fukuda, K Kusano, A Scheynius, I Mittermann, Y Resch-Marat, S Vrtala, R Valenta, E Marti, C Rhyner, R Crameri, R Satoh, R Teshima, A Tanaka, H Sato, H Matsuda, I Pali-Schöll, E Jensen-Jarolim
BACKGROUND: Companion animals are also affected by IgE-mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles. METHODS: Custom-designed allergen microarray was produced on the basis of the IimmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity...
January 19, 2018: Allergy
https://www.readbyqxmd.com/read/29345370/inhibition-of-soluble-epoxide-hydrolase-attenuates-eosinophil-recruitment-and-food-allergen-induced-gastrointestinal-inflammation
#2
Idil Bastan, Xiao Na Ge, Mythili Dileepan, Yana G Greenberg, Alonso G Guedes, Sung Hee Hwang, Bruce D Hammock, Robert J Washabau, Savita P Rao, P Sriramarao
Prevalence of food allergies in the United States is on the rise. Eosinophils are recruited to the intestinal mucosa in substantial numbers in food allergen-driven gastrointestinal (GI) inflammation. Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-inflammatory epoxyeicosatrienoic acids (EETs) to pro-inflammatory diols. We investigated the role of sEH in a murine model of food allergy and evaluated the potential therapeutic effect of a highly selective sEH inhibitor (trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]-cyclohexyloxy}-benzoic acid [t-TUCB])...
January 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29341526/-the-internal-medicine-articles-that-struck-us-the-most-in-2017
#3
Vanessa Kraege, Evrim Jaccard, Alain Kenfak, Elisabeth Stamm, Fanny Blondet, Grégoire Humair, Plamena Tasheva, Oriane Aebischer, Sabine Giroud, Jonathan Tschopp, Claudio Sartori
2017 has continued to bring important progress in all areas of internal medicine, impacting our daily practice. From bedside screening for beta-lactam allergies, to statins as primary prevention in the elderly, SGLT2 inhibitors in heart failure, azithromycin in severe asthmatics and tofacitinib in ulcero-haemorrhagic recto-colitis, internal medicine journals are full of novelties. Every year, the chief residents of the CHUV internal medicine ward meet up to share their readings: here is their selection of eleven articles, chosen, summarized and commented for you...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29332017/insulin-resistance-and-lung-function-in-obese-asthmatic-pre-pubertal-children
#4
Paola Di Filippo, Alessandra Scaparrotta, Daniele Rapino, Tommaso de Giorgis, Marianna Immacolata Petrosino, Marina Attanasi, Sabrina Di Pillo, Francesco Chiarelli, Angelika Mohn
BACKGROUND: Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR). METHODS: Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob)...
January 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29331422/fept-cys-nanoparticles-induce-ros-dependent-cell-toxicity-and-enhance-chemo-radiation-sensitivity-of-nsclc-cells-in-vivo-and-in-vitro
#5
Yingming Sun, Hongtao Miao, Shijing Ma, Lei Zhang, Chengcheng You, Fang Tang, Cui Yang, Xiaoli Tian, Feng Wang, Yuan Luo, Xiangjie Lin, Hui Wang, Chunyang Li, Zhijun Li, Hongnv Yu, Xuefeng Liu, Yu Xiao, Yan Gong, Junhong Zhang, Hong Quan, Conghua Xie
FePt-Cys nanoparticles (FePt-Cys NPs) have been well used in many fields, despite their poor solubility and stability. We synthetized a cysteine surface modified FePt NPs, which exhibited good solubility, stability and biocompatibility. We explored the insight mechanisms of the antitumor effects of this new nanoparticle system in lung cancer cells. In the in vitro study, FePt-Cys NPs induced a reactive oxygen species (ROS) burst, which suppressed the antioxidant protein expression and induced cell apoptosis...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29329957/safety-and-tolerability-of-a-novel-polyclonal-human-anti-mers-coronavirus-antibody-produced-from-transchromosomic-cattle-a-phase-1-randomised-double-blind-single-dose-escalation-study
#6
John H Beigel, Jocelyn Voell, Parag Kumar, Kanakatte Raviprakash, Hua Wu, Jin-An Jiao, Eddie Sullivan, Thomas Luke, Richard T Davey
BACKGROUND: Middle East respiratory syndrome (MERS) is a severe respiratory illness with an overall mortality of 35%. There is no licensed or proven treatment. Passive immunotherapy approaches are being developed to prevent and treat several human medical conditions where alternative therapeutic options are absent. We report the safety of a fully human polyclonal IgG antibody (SAB-301) produced from the hyperimmune plasma of transchromosomic cattle immunised with a MERS coronavirus vaccine...
January 9, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29329392/risk-of-pancreatic-cancer-associated-with-family-history-of-cancer-and-other-medical-conditions-by-accounting-for-smoking-among-relatives
#7
E Molina-Montes, P Gomez-Rubio, M Márquez, M Rava, M Löhr, C W Michalski, X Molero, A Farré, J Perea, W Greenhalf, L Ilzarbe, M O'Rorke, A Tardón, T Gress, V M Barberà, T Crnogorac-Jurcevic, E Domínguez-Muñoz, L Muñoz-Bellvís, J Balsells, E Costello, J Huang, M Iglesias, J Kleeff, Bo Kong, J Mora, L Murray, D O'Driscoll, I Poves, A Scarpa, W Ye, M Hidalgo, L Sharp, A Carrato, F X Real, N Malats
Background: Family history (FH) of pancreatic cancer (PC) has been associated with an increased risk of PC, but little is known regarding the role of inherited/environmental factors or that of FH of other comorbidities in PC risk. We aimed to address these issues using multiple methodological approaches. Methods: Case-control study including 1431 PC cases and 1090 controls and a reconstructed-cohort study (N = 16 747) made up of their first-degree relatives (FDR)...
January 10, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29326848/the-knowledge-of-eye-physicians-on-local-anesthetic-toxicity-and-intravenous-lipid-treatment-questionnaire-study
#8
Aykut Urfalıoğlu, Selma Urfalıoğlu, Gözen Öksüz
Objectives: To evaluate the knowledge of ophthalmologists regarding local anesthesia toxicity syndrome (LATS) and intravenous lipid emulsion used in treatment, and to raise awareness of this issue. Materials and Methods: A questionnaire comprising 14 questions about demographics, local anesthesia (LA) use, toxicity, and treatment methods was administered to ophthalmologists at different hospitals. Results: The study included 104 ophthalmologists (25% residents, 67...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29318631/early-life-gut-microbiome-and-egg-allergy
#9
Mina Fazlollahi, Yoojin Chun, Alexander Grishin, Robert A Wood, A Wesley Burks, Peter Dawson, Stacie M Jones, Donald Y M Leung, Hugh A Sampson, Scott H Sicherer, Supinda Bunyavanich
BACKGROUND: Gut microbiota may play a role in egg allergy. We sought to examine the association between early-life gut microbiota and egg allergy. METHODS: We studied 141 children with egg allergy and controls from the multi-center Consortium of Food Allergy Research study. At enrollment (age 3 to 16 months), fecal samples were collected and clinical evaluation, egg specific IgE measurement, and egg skin prick test were performed. Gut microbiome was profiled by 16S rRNA sequencing...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29318622/fish-oil-in-infancy-protects-against-food-allergy-in-iceland-results-from-a-birth-cohort-study
#10
Michael Clausen, Kristjan Jonasson, Thomas Keil, Kirsten Beyer, Sigurveig T Sigurdardottir
BACKGROUND: Consumption of oily fish or fish oil during pregnancy, lactation, and infancy has been linked to a reduction in the development of allergic diseases in childhood. METHODS: In an observational study, Icelandic children (n = 1304) were prospectively followed from birth to 2.5 years with detailed questionnaires administered at birth and at one and two years of age, including questions about fish oil supplementation. Children with suspected food allergy were invited for physical examinations, allergic sensitization tests, and a double-blind, placebo-controlled food challenge if the allergy testing or clinical history indicated food allergy...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29314223/delayed-type-hypersensitivity-to-vaccine-aluminum-adjuvant-causing-subcutaneous-leg-mass-and-urticaria-in-a-child
#11
Samantha C Gordon, Diana W Bartenstein, Shahein H Tajmir, Johanna S Song, Elena B Hawryluk
A 3-year-old girl presented with a 7-month history of a waxing and waning left thigh mass associated with pruritus and erythema at the site of two previous DTaP-HepB-IPV vaccinations. Patch testing was positive to aluminum chloride, supporting a diagnosis of vaccine granuloma secondary to aluminum allergy; her symptoms had been well controlled with antihistamines and topical steroids. Injection site granulomas are a benign but potentially bothersome reaction to aluminum-containing immunizations that can be supportively managed, and we encourage strict adherence to the recommended vaccine schedule in this setting...
January 4, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29310755/home-environmental-interventions-for-house-dust-mite
#12
Jeffrey M Wilson, Thomas A E Platts-Mills
It has been 50 years since the dust mite was first appreciated to be a major source of allergen in house dust, and by extension a key trigger of allergic respiratory disease. Since that time a number of protein allergens have been identified and characterized, mainly from mite feces, and standardized mite extracts and IgE assays have been developed. Insights into the lifecycle of dust mites and aspects of mite allergen biology have shed light on the mechanisms that lead to respiratory disease and to the development of interventions that can minimize dust mite allergen exposure...
January 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29300005/food-allergy
#13
REVIEW
Harald Renz, Katrina J Allen, Scott H Sicherer, Hugh A Sampson, Gideon Lack, Kirsten Beyer, Hans C Oettgen
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic shock. Major progress has been made in basic, translational and clinical research, leading to a better understanding of the underlying immunological mechanisms that lead to the breakdown of clinical and immunological tolerance against food antigens, which can result in either immunoglobulin E (IgE)-mediated reactions or non-IgE-mediated reactions...
January 4, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29294541/-prediction-of-occupational-allergic-contact-dermatitis-induced-by-formaldehyde-by-il17-il22-secretion-cell-rest-combined-with-patch-test
#14
W H Mai, X W Liu, G X Su, Z P Wen
Objective: To investigate the possible role of IL17-and IL22-secreting cells combined with patch test for the prediction of formaldehyde-induced occupational allergic contact dermatitis(OACD). Methods: From October 2014 to October 2016, totally 131 formaldehyde-exposed workers(49 cases with inflammatory skin lesions,82 ones without inflammatory skin lesions)and 63 non-exposed health controls were recruited. Patch-test was performed in 49 cases of formaldehyde-exposed workers with inflammatory skin lesions. Circulating IL17+and IL22+Tcell subsets were assessed by flow cytometry(FCM)...
October 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29288643/a-case-crossover-study-of-urologic-chronic-pelvic-pain-syndrome-flare-triggers-in-the-mapp-research-network
#15
Siobhan Sutcliffe, Thomas Jemielita, H Henry Lai, Gerald L Andriole, Catherine S Bradley, J Quentin Clemens, Robert Gallop, Thomas M Hooton, Karl J Kreder, John N Krieger, John W Kusek, Jennifer Labus, M Scott Lucia, Sean Mackey, Bruce D Naliboff, Nancy A Robinson, Larissa V Rodriguez, Alisa Stephens-Shields, Adrie van Bokhoven, Kathleen Y Wolin, Yan Yan, Claire C Yang, J Richard Landis, Graham A Colditz
PURPOSE: Although many factors have been proposed to trigger symptom exacerbations ("flares") in patients with interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, few studies have investigated these factors empirically. Therefore, we embedded a case-crossover study in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain longitudinal study to evaluate a range of patient-reported triggers. MATERIALS AND METHODS: Exposure to proposed triggers (diet, physical activities, sedentary behaviors, stress, sexual activities, infection-like symptoms, and allergies) was assessed by questionnaire a maximum of three times when participants reported flares and at three randomly-selected times...
December 27, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29285209/combination-of-il-2-rapamycin-dna-methyltransferase-and-histone-deacetylase-inhibitors-for-the-expansion-of-human-regulatory-t-cells
#16
Makoto Miyara, Driss Chader, Aude Burlion, Jérémie Goldstein, Delphine Sterlin, Françoise Norol, Hélène Trebeden-Nègre, Laetitia Claër, Shimon Sakaguchi, Gilles Marodon, Zahir Amoura, Guy Gorochov
FOXP3+ regulatory T cell (Treg) based cellular therapies represent promising therapeutic options in autoimmunity, allergy, transplantation and prevention of Graft Versus Host (GVH) Disease. Among human FOXP3-expressing CD4+T cells, only the CD45RA+ naïve Treg (nTreg) subset is suitable for in vitro expansion. However, FoxP3 expression decays in cells using currently described culture protocols. Rapamycin alone was not able to prevent FOXP3 loss in nTregs cells, as only a half of them maintained FOXP3 expression after 14 days of culture...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29279933/effect-of-antibiotic-prophylaxis-on-surgical-site-infections-following-removal-of-orthopedic-implants-used-for-treatment-of-foot-ankle-and-lower-leg-fractures-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Manouk Backes, Siem A Dingemans, Marcel G W Dijkgraaf, H Rogier van den Berg, Bart van Dijkman, Jochem M Hoogendoorn, Pieter Joosse, Ewan D Ritchie, W Herbert Roerdink, Judith P M Schots, Nico L Sosef, Ingrid J B Spijkerman, Bas A Twigt, Alexander H van der Veen, Ruben N van Veen, Jefrey Vermeulen, Dagmar I Vos, Jasper Winkelhagen, J Carel Goslings, Tim Schepers
Importance: Following clean (class I, not contaminated) surgical procedures, the rate of surgical site infection (SSI) should be less than approximately 2%. However, an infection rate of 12.2% has been reported following removal of orthopedic implants used for treatment of fractures below the knee. Objective: To evaluate the effect of a single dose of preoperative antibiotic prophylaxis on the incidence of SSIs following removal of orthopedic implants used for treatment of fractures below the knee...
December 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29277095/management-and-educational-status-of-adult-anaphylaxis-patients-at-emergency-department
#18
Mi-Yeong Kim, Chan Sun Park, Jae-Won Jeong
Background/Aims: We evaluated the management and educational status of adult anaphylaxis patients at emergency departments (EDs). Methods: Anaphylaxis patients who visited ED from 2011 to 2013 were enrolled from three hospitals. We analyzed clinical features, prior history of anaphylaxis, management and provided education for etiology and/or prevention. For analyzing associated factors with epinephrine injection, Pearson chi-square test was used by SPSS version 21 (IBM Co...
December 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29274967/milk-basic-protein-supplementation-exerts-an-anti-inflammatory-effect-in-a-food-allergic-enteropathy-model-mouse
#19
Aiko Ono-Ohmachi, Haruyo Nakajima-Adachi, Yoshikazu Morita, Ken Kato, Satoshi Hachimura
To examine novel functions of milk basic protein (MBP) in T-cell-related inflammatory diseases, such as autoimmune diseases and allergies, we evaluated the effects of MBP on the causative responses of ovalbumin (OVA)-specific T cells in a food-allergic enteropathy model, OVA23-3 mice, which express an OVA-specific T-cell receptor gene. The OVA-specific CD4+ T cells of the mesenteric lymph nodes (MLN) from OVA23-3 mice were cultured with CD11c+ dendritic cells of MLN from BALB/cA mice in the absence or presence of MBP following stimulation with OVA; then the levels of CD69 expression and the levels of cytokine production by CD4+ T cells were measured to evaluate activation...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29248229/breastfeeding-associated-microbiota-in-human-milk-following-supplementation-with-lactobacillus-rhamnosus-gg-lactobacillus-acidophilus-la-5-and-bifidobacterium-animalis-subspecies-lactis-bb-12
#20
Melanie Rae Simpson, Ekaterina Avershina, Ola Storrø, Roar Johnsen, Knut Rudi, Torbjørn Øien
Breastfeeding is one of the major factors affecting the early development of the infant gut microbiota, and weaning is associated with a shift in the gut microbiota toward a more adult composition. Through breastfeeding, infants receive bioactive components that shape their microbiota while also being exposed to the breast milk and breast surface microbial communities. Recent studies have suggested the possibility of an entero-mammary route of microbial transfer, opening the possibility of infant gut microbiota modulation through maternal probiotic supplementation...
December 13, 2017: Journal of Dairy Science
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