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https://www.readbyqxmd.com/read/28102702/immunomodulating-peptides-for-food-allergy-prevention-and-treatment
#1
Daniel Lozano-Ojalvo, Rosina López-Fandiño
Among the most promising strategies currently assayed against IgE-mediated allergic diseases stands the possibility of using immunomodulating peptides to induce oral tolerance towards offending food allergens or even to prevent allergic sensitization. This review focuses on the beneficial effects of food derived immunomodulating peptides on food allergy, which can be directly exerted in the intestinal tract or once being absorbed through the intestinal epithelial barrier to interact with immune cells. Food peptides influence intestinal homeostasis by maintaining and reinforcing barrier function or affecting intestinal cell-signalling to nearby immune cells and mucus secretion...
January 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28097361/folic-acid-supplementation-for-the-prevention-of-neural-tube-defects-an-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#2
Meera Viswanathan, Katherine A Treiman, Julia Kish-Doto, Jennifer C Middleton, Emmanuel J L Coker-Schwimmer, Wanda K Nicholson
Importance: Neural tube defects are among the most common congenital anomalies in the United States. Periconceptional folic acid supplementation is a primary care-relevant preventive intervention. Objective: To review the evidence on folic acid supplementation for preventing neural tube defects to inform the US Preventive Services Task Force for an updated Recommendation Statement. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries through January 28, 2016, with ongoing surveillance through November 11, 2016; references; experts...
January 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28095816/awareness-and-knowledge-among-internal-medicine-house-staff-for-dose-adjustment-of-commonly-used-medications-in-patients-with-ckd
#3
Sikander Surana, Neeru Kumar, Amita Vasudeva, Gulvahid Shaikh, Kenar D Jhaveri, Hitesh Shah, Deepa Malieckal, Joshua Fogel, Gurwinder Sidhu, Sofia Rubinstein
BACKGROUND: Drug dosing errors result in adverse patient outcomes and are more common in patients with chronic kidney disease (CKD). As internists treat the majority of patients with CKD, we study if Internal Medicine house-staff have awareness and knowledge about the correct dosage of commonly used medications for those with CKD. METHODS: A cross-sectional survey was performed and included 341 participants. The outcomes were the awareness of whether a medication needs dose adjustment in patients with CKD and whether there was knowledge for the level of glomerular filtration rate (GFR) a medication needs to be adjusted...
January 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28077121/awareness-of-food-allergies-a-survey-of-pediatricians-in-kuwait
#4
Waleed Al-Herz, Khalid Husain, Ahmed Al-Khabaz, Mohamed A A Moussa, Fawaz Al-Refaee
BACKGROUND: Early diagnosis of food allergies (FA) is important for a favorable prognosis. This study aimed to determine the level of awareness of FA among pediatricians in Kuwait. METHOD: A 43-item self-administered questionnaire was designed and distributed to pediatricians working at 4 government hospitals in Kuwait. RESULTS: A total of 140 pediatricians completed the questionnaire, with a participation rate of 51.1% (81 males and 59 females)...
January 11, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28068145/comparison-of-patient-health-history-questionnaires-used-in-general-internal-and-family-medicine-integrative-medicine-and-complementary-and-alternative-medicine-clinics
#5
Justin G R Laube, Martin F Shapiro
OBJECTIVES: Health history questionnaires (HHQs) are a set of self-administered questions completed by patients prior to a clinical encounter. Despite widespread use, minimal research has evaluated the content of HHQs used in general internal medicine and family medicine (GIM/FM), integrative medicine, and complementary and alternative medicine (CAM; chiropractic, naturopathic, and Traditional Chinese Medicine [TCM]) clinics. Integrative medicine and CAM claim greater emphasis on well-being than does GIM/FM...
January 9, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28065802/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-report-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#6
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy...
December 30, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28065278/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-report-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#7
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28057759/potent-nlrp3-inflammasome-activation-by-the-hiv-reverse-transcriptase-inhibitor-abacavir
#8
Atiye Toksoy, Helga Sennefelder, Christian Adam, Sonja Hofmann, Axel Trautmann, Matthias Goebeler, Marc Schmidt
There is experimental and clinical evidence that some exanthematous allergic drug hypersensitivity reactions are mediated by drug-specific T cells. We hypothesized that the capacity of certain drugs to directly stimulate the innate immune system may contribute to generate drug-specific T cells. Here we analyzed whether abacavir, an HIV-1 reverse transcriptase inhibitor often inducing severe delayed-type drug hypersensitivity, can trigger innate immune activation that may contribute to its allergic potential...
January 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28054723/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-report-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#9
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy...
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28054718/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-summary-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#10
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
No abstract text is available yet for this article.
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28049206/novel-mechanisms-underlying-the-therapeutic-effect-of-glycomacropeptide-on-allergy-change-in-gut-microbiota-upregulation-of-tgf-%C3%AE-and-inhibition-of-mast-cells
#11
Mariela Jiménez, Daniel Cervantes-García, Yualli Haydee Muñoz, Alejandra García, Luis Miguel Haro, Eva Salinas
BACKGROUND: The prevalence of allergic diseases is globally increasing. We have previously described that glycomacropeptide (GMP), a bioactive milk peptide, has therapeutic value in experimental models of skin hypersensitivity, anaphylaxis, and asthma, as it prevents an excessive T helper type 2 cell immune response. The aim of this study was to analyze the effect of GMP on key elements directly involved in the development or control of allergy, in order to improve the precise knowledge about its mechanism of action...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28045938/exposure-to-indoor-allergens-in-different-residential-settings-and-its-influence-on-ige-sensitization-in-a-geographically-confined-austrian-cohort
#12
Teresa Stemeseder, Bettina Schweidler, Patrick Doppler, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Martin Himly, Roland Lang, Joerg Zumbach, Gertie J Oostingh, Thomas Hawranek, Arne C Bathke, Gabriele Gadermaier
BACKGROUND: Exposure to indoor allergens is crucial for IgE sensitization and development of allergic symptoms. Residential settings influence the allergen amount in house dust and hence allergic sensitization. Within this study, we investigated allergen exposure and molecule-based IgE levels in a geographically confined region and evaluated the impact of housing, pets and cleaning. METHODS: 501 adolescents from Salzburg, Austria participated in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28043595/reaching-consensus-on-drug-resistance-conferring-mutations
#13
Daniela M Cirillo, Paolo Miotto, Elisa Tagliani
OBJECTIVE/BACKGROUND: Molecular-based, rapid drug-susceptibility tests are needed to guide the appropriate use of new drugs and new therapeutic regimens at the programmatic level, and to prevent a further increase in the incidence of drug-resistant tuberculosis (TB). Experts have recognized the need for a global, curated, and standardized analysis and data-sharing platform that provides a one-stop data source for clinically relevant genotypic and phenotypic information on Mycobacterium tuberculosis...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#14
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28029408/gut-microbiota-and-allergy-asthma-from-pathogenesis-to-new-therapeutic-strategies
#15
REVIEW
Y B Kang, Y Cai, H Zhang
Asthma and atopy, classically associated with hyper-activation of the T helper 2 (Th2) arm of adaptive immunity, are among the most common chronic illnesses worldwide. Emerging evidence relates atopy and asthma to the composition and function of gut microbiota composition. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. Although still a relatively nascent field of research, evidence to date suggests that the gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature...
October 28, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28025415/japanese-pediatric-guideline-for-food-allergy-2016-how-to-prevent-complete-avoidance
#16
Motohiro Ebisawa
No abstract text is available yet for this article.
2016: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28007673/rubber-new-allergens-and-preventive-measures
#17
Marie-Noëlle Crepy
Natural rubber latex (NRL) and rubber accelerators are well-known causes of occupational skin diseases. The latest epidemiological data on rubber allergy show that rubber additives are still among the allergens most strongly associated with occupational contact dermatitis, however, a decrease in NRL allergy has been confirmed. A review of recent publications on rubber allergens based on the Pubmed database is presented. New glove manufacturing processes have been developed, such as low-protein natural rubber gloves, vulcanisation accelerator-free gloves, or specific-purpose gloves containing antimicrobial agents or moisturisers...
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28005962/health-related-factors-associated-with-discrepancies-between-children-s-potential-and-attained-secondary-school-level-a-longitudinal-study
#18
Iris van der Heide, Ulrike Gehring, Gerard H Koppelman, Alet H Wijga
OBJECTIVES: This longitudinal study examines children's health-related characteristics in relation to discrepancies between their educational potential assessed by a cognitive test in primary school at age 11 and their attained secondary school level at age 14. METHODS: Data were used from 1510 participants of the Dutch PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort. Multiple multinomial logistic regression analyses were used to estimate the associations between indicators of physical health, psychosocial health, lifestyle, sleeping patterns and stressful life events and attending a higher or lower level of secondary education than indicated by the cognitive test...
2016: PloS One
https://www.readbyqxmd.com/read/28005295/antibiotics-in-endodontics-a-review
#19
REVIEW
J J Segura-Egea, K Gould, B Hakan Şen, P Jonasson, E Cotti, A Mazzoni, H Sunay, L Tjäderhane, P M H Dummer
The overuse of antibiotics and the emergence of antibiotic-resistant bacterial strains is a global concern. This concern is also of importance in terms of the oral microbiota and the use of antibiotics to deal with oral and dental infections. The aim of this paper is to review the current literature on the indications and use of antibiotics and to make recommendations for their prescription in endodontic patients. Odontogenic infections, including endodontic infections, are polymicrobial, and in most cases, the prescription of antibiotics is empirical...
December 22, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/28005035/-acute-respiratory-viral-infections-topical-issues-of-diagnosis-prevention-and-treatment-in-therapeutic-practice
#20
D I Trukhan, A L Mazurov, L A Rechapova
AIM: to assess the efficacy and safety of the medication Grippferon with loratadine for the prevention of acute respiratory viral infections (ARVI) and influenza during the epidemics. MATERIAL AND METHODS: This study included 103 patients (67 men and 36 women) aged 18 to 52 years (mean age 35.3±3.2 years). During the first visit (september 2015), we collected patient history data on the average rate of ARVI and influenza for the past three years, the disease duration and its symptoms, presence of concomitant allergic pathologies (such as vasomotor rhinitis, hay fever and urticaria) and food allergies...
2016: Terapevticheskiĭ Arkhiv
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