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https://www.readbyqxmd.com/read/29145201/dietary-fructo-oligosaccharides-attenuate-early-activation-of-cd4-t-cells-which-produce-both-th1-and-th2-cytokines-in-the-intestinal-lymphoid-tissues-of-a-murine-food-allergy-model
#1
Masato Tsuda, Haruka Arakawa, Narumi Ishii, Chihiro Ubukata, Mana Michimori, Masanari Noda, Kyoko Takahashi, Shuichi Kaminogawa, Akira Hosono
BACKGROUND: Fructo-oligosaccharides (FOS) are prebiotic agents with immunomodulatory effects involving improvement of the intestinal microbiota and metabolome. In this study, we investigated the cellular mechanisms through which FOS modulate intestinal antigen-specific CD4+ T cell responses in food allergy, using OVA23-3 mice. METHODS: OVA23-3 mice were fed an experimental diet containing either ovalbumin (OVA) or OVA and FOS for 1 week. Body weight and mucosal mast cell protease 1 in the serum were measured as the indicator of intestinal inflammation...
November 17, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29134229/decursin-and-decursinol-angelate-molecular-mechanism-and-therapeutic-potential-in-inflammatory-diseases
#2
REVIEW
Adeeb Shehzad, Sajida Parveen, Munibah Qureshi, Fazli Subhan, Young Sup Lee
Epidemiological studies have shown that inflammation plays a critical role in the development and progression of various chronic diseases, including cancers, neurological diseases, hepatic fibrosis, diabetic retinopathy, and vascular diseases. Decursin and decursinol angelate (DA) are pyranocoumarin compounds obtained from the roots of Angelica gigas. Several studies have described the anti-inflammatory effects of decursin and DA. Decursin and DA have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated B cells, cellular enzymes including matrix metalloproteinases cyclooxygenase, and protein kinases such as extracellular receptor kinase, phosphatidylinositol-3-kinase, and protein kinase C...
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29132673/diagnosis-of-food-allergy
#3
REVIEW
Malika Gupta, Amanda Cox, Anna Nowak-Węgrzyn, Julie Wang
Food allergy diagnosis remains challenging. Most standard methods are unable to differentiate sensitization from clinical allergy. Recognizing food allergy is of utmost importance to prevent life-threatening reactions. On the other hand, faulty interpretation of tests leads to overdiagnosis and unnecessary food avoidances. Highly predictive models have been established for major food allergens based on skin prick testing and food-specific immunoglobulin E but are lacking for most other foods. Although many newer diagnostic techniques are improving the accuracy of food allergy diagnostics, an oral food challenge remains the only definitive method of confirming a food allergy...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29132666/prevention-of-food-allergies
#4
REVIEW
Jennifer J Koplin, Rachel L Peters, Katrina J Allen
This review summarizes the current state of play with regard to food allergy prevention. Food allergy prevention strategies focused on promoting timely introduction of allergenic foods (predominantly peanut) into the infant diet have recently been introduced in several countries. Additional prevention strategies currently under investigation include optimizing infant vitamin D levels, modulating the gut microbiota through use of probiotics, and preventing eczema to reduce the risk of food sensitization through a damaged skin barrier...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29126272/generation-of-alloantigen-specific-induced-treg-stabilized-by-vitamin-c-treatment-and-its-application-for-prevention-of-acute-graft-versus-host-disease-model
#5
Hidenori Kasahara, Taisuke Kondo, Hiroko Nakatsukasa, Shunsuke Chikuma, Minako Ito, Makoto Ando, Yutaka Kurebayashi, Takashi Sekiya, Taketo Yamada, Shinichiro Okamoto, Akihiko Yoshimura
Antigen-specific regulatory T cells (Tregs) possess the potential to reduce excess immune responses in autoimmune diseases, allergy, rejection after organ transplantation, and graft-versus-host disease (GVHD) in hematopoietic stem-cell transplantation. Although in vitro-expanded antigen-specific induced Tregs (iTregs) have been considered to be a promising therapeutic agent against such excessive immune reactions, the instability of iTregs after transfer is a fundamental problem in their clinical application...
November 4, 2017: International Immunology
https://www.readbyqxmd.com/read/29124699/asthma-and-allergy-epidemic-and-the-role-of-vitamin-d-deficiency
#6
Konstantinos Douros, Barbara Boutopoulou, Sotirios Fouzas, Ioanna Loukou
The increase in asthma and allergies prevalence that has been recorded in many countries during the last decades, and the reemergence of vitamin D (VD) deficiency in many populations worldwide, renders fairly plausible the assumption of an underlying association between these two conditions and justifies the research effort invented in this issue. Indeed, there is growing body of evidence from epidemiological, laboratory, and clinical studies, suggesting that such an association does exist. The hypothesis of low levels of VD leading to compromised fetal programming and impairment of various immune functions involved in asthma and allergic disorders, stands as the most credible explanation of this presumed association...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29123869/drug-induced-anaphylaxis-in-the-emergency-room
#7
REVIEW
Tomonori Takazawa, Kiyohiro Oshima, Shigeru Saito
Anaphylaxis is a life-threatening, systemic allergic reaction that presents unique challenges for emergency care practitioners. Anaphylaxis occurs more frequently than previously believed. Therefore, proper knowledge regarding the epidemiology, mechanisms, symptoms, diagnosis, and treatment of anaphylaxis is essential. In particular, the initial treatment strategy, followed by correct diagnosis, in the emergency room is critical for preventing fatal anaphylaxis, although making a diagnosis is not easy because of the broad and often atypical presentation of anaphylaxis...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29123515/dietary-intervention-with-%C3%AE-lactoglobulin-derived-peptides-and-a-specific-mixture-of-fructo-oligosaccharides-and-bifidobacterium-breve-m-16v-facilitates-the-prevention-of-whey-induced-allergy-in-mice-by-supporting-a-tolerance-prone-immune-environment
#8
Atanaska I Kostadinova, Alba Pablos-Tanarro, Mara A P Diks, Betty C A M van Esch, Johan Garssen, Léon M J Knippels, Linette E M Willemsen
Cow's milk allergy (CMA) prevails in infants and brings increased risk of developing other allergic diseases. Oral administration of specific β-lactoglobulin (BLG)-derived peptides (PepMix) and a specific blend of short- and long-chain fructo-oligosaccharides and Bifidobacterium breve M-16V (FF/Bb) was found to partially prevent CMA development in mice. In this study, we aimed to expand the knowledge on the preventive potential and the underlying mechanisms of this approach. Three-week-old female C3H/HeOuJ mice were orally exposed to PepMix±FF/Bb prior to a 5-week oral sensitization with whole whey and cholera toxin as an adjuvant...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29123241/toxoplasma-gondii-tachyzoite-extract-acts-as-a-potent-immunomodulator-against-allergic-sensitization-and-airway-inflammation
#9
Mirjana Drinić, Angelika Wagner, Priya Sarate, Christian Zwicker, Elke Korb, Gerhard Loupal, Roman Peschke, Anja Joachim, Ursula Wiedermann, Irma Schabussova
Epidemiological and experimental studies have shown an inverse relationship between infections with certain parasites and a reduced incidence of allergic diseases. We and others have shown that infection with Toxoplasma gondii prevents the development of allergy in mice. To establish whether this beneficial effect could be recapitulated by soluble products of this parasite, we tested an extract derived from T. gondii tachyzoites. Immunization of BALB/c mice with tachyzoites lysate antigen (TLA) elicited mixed Th1/Th2 responses...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121702/preventive-effects-of-a-probiotic-mixture-in-an-ovalbumin-induced-food-allergy-model
#10
Hee-Soon Shin, Ji-Eun Eom, Dong-Uk Shin, Sung-Hum Yeon, Seong-Il Lim, So-Young Lee
Although there has been a steady increase in the prevalence of food allergies worldwide in recent decades, no effective therapeutic strategies have been developed. Modulation of the gut microbiota composition and/or function through probiotics has been highlighted as a promising target for protection against food allergies. In this study, we aimed to investigate the allergy-reducing effects of a probiotic mixture (P5: Lactococcus lactis KF140, Pediococcus pentosaceus KF159, Lactobacillus pentosus KF340, Lactobacillus paracasei 698, and Bacillus amyloliquefaciens 26N) in mice with ovalbumin (OVA)-induced food allergy...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29117431/food-allergy-and-atopic-dermatitis-prediction-progression-and-prevention
#11
REVIEW
Carla Mastrorilli, Carlo Caffarelli, Karin Hoffmann-Sommergruber
The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depends on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution and infections. Preventive strategies may include avoidance measures, diet supplements and early complementary food introduction...
November 8, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29110085/safety-of-first-line-triple-therapy-with-a-potassium-competitive-acid-blocker-for-helicobacter-pylori-eradication-in-children
#12
Chika Kusano, Takuji Gotoda, Sho Suzuki, Hisatomo Ikehara, Mitsuhiko Moriyama
BACKGROUND: Helicobacter pylori infection is a risk factor for gastric cancer, and it has been reported that eradication of H. pylori is effective for preventing such cancer. Recently, H. pylori eradication has been performed in children as first-line therapy against gastric cancer. Here, we report use of triple therapy with a potassium-competitive acid blocker (P-CAB) for H. pylori eradication in children. METHODS: H. pylori infection testing and eradication therapy began in fiscal year 2015 in junior high school students located in Yurihonjo city and Nikaho city, Akita prefecture, Japan...
November 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29108604/global-issues-in-allergy-and-immunology-parasitic-infections-and-allergy
#13
REVIEW
Alvaro A Cruz, Philip J Cooper, Camila A Figueiredo, Neuza M Alcantara-Neves, Laura C Rodrigues, Mauricio L Barreto
Allergic diseases are on the increase globally in parallel with a decrease in parasitic infection. The inverse association between parasitic infections and allergy at an ecological level suggests a causal association. Studies in human subjects have generated a large knowledge base on the complexity of the interrelationship between parasitic infection and allergy. There is evidence for causal links, but the data from animal models are the most compelling: despite the strong type 2 immune responses they induce, helminth infections can suppress allergy through regulatory pathways...
November 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29105793/what-can-we-learn-in-drug-allergy-management-from-world-health-organization-s-international-classifications
#14
REVIEW
Luciana Kase Tanno, Maria Jose Torres, Mariana Castells, Pascal Demoly
Drug hypersensitivity reactions (DHRs) represent growing health problem worldwide, affecting more than 7% of the general population and represent an important public health problem. However, knowledge in DHRs morbidity and mortality epidemiological data is still not optimal and international comparable standards remain poorly accessed. Institutional databases worldwide increasingly use the WHO International Classification of Diseases (ICD) system to classify diagnoses, health services utilization and death data...
November 6, 2017: Allergy
https://www.readbyqxmd.com/read/29102311/environmental-and-molecular-study-of-fungal-flora-in-asthmatic-patients
#15
H Trablesi, I Hadrich, S Neji, N Fendri, D Ghorbel, F Makni, H Ayadi, S Kammoun, A Ayadi
The aim of the present study was to investigate the epidemiological and fungal environmental profile in asthmatic patients. We conducted a prospective study involving 49 patients with allergic asthma. One hundred and forty-five clinical samples and 289 environmental samples were performed. Only 30 patients accepted to participate to the environmental study at their home. For specific IgE antibodies, ELISA assay was conducted for 21 patients. Molecular ITS sequencing was performed for 37 isolates. The frequency of attacks was significantly associated with the seasonality, which was closely related to climate (P=0...
October 25, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29097103/the-allergen-specificity-of-early-peanut-consumption-and-the-impact-on-the-development-of-allergic-disease-in-the-leap-study-cohort
#16
George du Toit, Peter H Sayre, Graham Roberts, Kaitie Lawson, Michelle L Sever, Henry T Bahnson, Helen R Fisher, Mary Feeney, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack
BACKGROUND: Early introduction of dietary peanut in high-risk infants with severe eczema and/or egg allergy prevented peanut allergy at 5 years of age in the LEAP Study; the protective effect persisted after 12 months of avoiding peanuts in the LEAP-On Study. It is unclear whether this benefit is allergen and allergic-disease specific. OBJECTIVE: To assess the impact of early introduction of peanut on the development of allergic disease, food sensitization and aeroallergen sensitization...
October 30, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29079360/plga-nanoparticles-loaded-with-beta-lactoglobulin-derived-peptides-modulate-mucosal-immunity-and-may-facilitate-cow-s-milk-allergy-prevention
#17
Atanaska I Kostadinova, Jim Middelburg, Michele Ciulla, Johan Garssen, Wim E Hennink, Leon M J Knippels, Cornelus F van Nostrum, Linette E M Willemsen
Beta-lactoglobulin (BLG)-derived peptides may facilitate oral tolerance to whey and prevent cow's milk allergy (CMA). Loading of BLG-peptides in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Pep-NP) may improve this. Here we studied the uptake of NP and the capacity of NP and Pep-NP to activate bone marrow dendritic cells (BMDC). Furthermore, CMA prevention was evaluated by orally exposing three-week-old female C3H/HeOuJ mice to Pep-NP, NP or free peptides (PepMix) for 6 days before oral sensitization with whole whey protein and effects on the spleen and small intestine lamina propria (SI-LP) were studied...
October 25, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29077390/lab-on-chip-devices-gaining-ground-losing-size
#18
Veronica C Romao, Sofia A M Martins, Jose Germano, Filipe A Cardoso, Susana Cardoso, Paulo P Freitas
Portable analytical devices are notably gaining relevance in the panorama of urgent testing. Such devices have the potential to play an important role as easy-to-handle tools in critical situations. Epidemic infectious disease agents (e.g., Ebola virus, Coronavirus, Zika virus) could be controlled more easily by testing travelers on-site at the country borders to prevent outbreaks from spreading. The increasing incidence of hospital-acquired infections caused by antibiotic resistant pathogens could be minimized by point-of-care microbial analysis as well as rapid screening tests of bacteria resistance...
October 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29068090/early-introduction-of-allergenic-foods-for-the-prevention-of-food-allergy-from-an-asian-perspective-an-apapari-consensus-statement
#19
REVIEW
E H Tham, L P Shek, H P Van Bever, P Vichyanond, M Ebisawa, G W K Wong, B W Lee
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the US and Europe recommending early peanut introduction for high-risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent in Asia compared to the West. Varying patterns of food allergy are seen even within Asian countries - such as a predominance of wheat allergy in Japan and Thailand and shellfish allergy in Singapore and the Philippines...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29066481/acetylsalicylic-acid-during-leukapheresis-reduces-the-incidence-of-clotting-in-hematopoietic-progenitor-cell-products
#20
Soumya Pandey, Michele Cottler-Fox
INTRODUCTION: Clots may be seen during hematopoietic progenitor cell (HPC) collection or on product arrival to the cell therapy processing laboratory. We have always given one 81 mg acetylsalicylic acid (ASA) when clotting is seen during collection if there is no allergy, but hypothesized that the incidence of clotting would decrease if ASA was given to all autologous collectors with a platelet count of ≥80×10(9)/L prior to collection (pre-emptively). METHODS: Autologous HPC were collected using the Spectra Optia instrument or Cobe Spectra instrument (Terumo BCT(®), Lakewood, CO) with heparinized citrate...
September 2017: Annals of Clinical and Laboratory Science
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