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https://www.readbyqxmd.com/read/29781731/neuropsychologists-as-primary-care-providers-of-cognitive-health-a-novel-comprehensive-cognitive-wellness-service-delivery-model
#1
Patricia A Pimental, John B O'Hara, Jessica L Jandak
By virtue of their extensive knowledge base and specialized training in brain-behavior relationships, neuropsychologists are especially poised to execute a unique broad-based approach to overall cognitive wellness and should be viewed as primary care providers of cognitive health. This article will describe a novel comprehensive cognitive wellness service delivery model including cognitive health, anti-aging, lifelong wellness, and longevity-oriented practices. These practice areas include brain-based cognitive wellness, emotional and spiritually centric exploration, and related multimodality health interventions...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29779911/piloting-medication-histories-in-a-pediatric-postanesthesia-care-unit
#2
Nathan Lake, Humaira Nawer, Deborah Wagner
PURPOSE: Develop a medication history process for pediatric postanesthesia care unit (PACU) patients to identify discrepancies between home and inpatient medications and prevent medication errors. DESIGN: Pilot an evidence-based practice change to perform PACU medication histories. METHODS: Inpatients or surgical admissions to general care units at a pediatric tertiary care 348-bed hospital ages 2-18 years were included. Parents/guardians were asked about their child's prescription and over-the-counter medications, allergies, and adherence...
May 18, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29779209/gata3-hypermethylation-and-foxp3-hypomethylation-are-associated-with-sustained-protection-and-bystander-effect-following-epicutaneous-immunotherapy-in-peanut-sensitized-mice
#3
Lucie Mondoulet, Vincent Dioszeghy, Florence Busato, Camille Plaquet, Véronique Dhelft, Kevin Bethune, Laurence Leclere, Christian Daviaud, Mélanie Ligouis, Hugh Sampson, Christophe Dupont, Jörg Tost
BACKGROUND: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kinetics of DNA methylation changes in sorted cells from spleen and blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT). METHODS: BALB/c mice orally sensitized to peanut proteins (PPE) were treated by EPIT using a PPE-patch or by PPE-OIT...
May 19, 2018: Allergy
https://www.readbyqxmd.com/read/29778497/food-groups-for-allergen-risk-assessment-combining-food-consumption-data-from-different-countries-in-europe
#4
Sophie Birot, Charlotte B Madsen, Astrid G Kruizinga, Amélie Crépet, Tue Christensen, Per B Brockhoff
To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan-European food data suitable for food allergy risk assessment. The aim of this paper is to investigate if consumption data, at a meal level, from National Food Consumption Surveys, can be combined to form a common Food Consumption database...
May 17, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29771132/comparative-diagnostics-of-allergy-using-quantitative-immuno-pcr-and-elisa
#5
Maria A Simonova, Victor D Pivovarov, Dmitry Y Ryazantsev, Anna S Dolgova, Valentina M Berzhets, Sergei K Zavriev, Elena V Svirshchevskaya
AIM: Estimation of specific IgE is essential for the prevention of allergy progression. Quantitative immuno-PCR (qiPCR) can increase the sensitivity of IgE detection. We aimed to develop qiPCR and compare it to the conventional ELISA in identification of IgE to Alt a 1 and Fel d 1 allergens. RESULTS: Single stranded 60-mer DNA conjugated to streptavidin was used to detect antigen-IgE-biotin complex by qiPCR. In semi-logarithmic scale qiPCR data were linear in a full range of serum dilutions resulting in three- to ten-times higher sensitivity of qiPCR in comparison with ELISA in IgE estimation in low titer sera...
May 17, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29767340/speculation-as-to-why-the-frequency-of-eosinophilic-esophagitis-is-increasing
#6
REVIEW
Stuart Jon Spechler
PURPOSE OF REVIEW: The frequency of eosinophilic esophagitis (EoE), an immune/antigen-mediated disorder first described in 1993, has been increasing rapidly. The purpose of this review is to consider hypotheses proposed to explain this increase and to speculate on their validity. RECENT FINDINGS: The hygiene hypothesis attributes the rise of EoE to modern hygienic conditions resulting in fewer childhood infections with microbes that might have protected against allergy development...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#7
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29760613/latex-immunotherapy-evidence-of-effectiveness
#8
Eleonora Nucera, Simona Mezzacappa, Alessandro Buonomo, Michele Centrone, Angela Rizzi, Paolo Francesco Manicone, Giampiero Patriarca, Arianna Aruanno, Domenico Schiavino
Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29759659/the-global-development-and-clinical-efficacy-of-sublingual-tablet-immunotherapy-for-allergic-diseases
#9
REVIEW
Hendrik Nolte, Jennifer Maloney
Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies...
May 12, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29757781/misconceptions-surrounding-penicillin-allergy-implications-for-anesthesiologists
#10
Leon Vorobeichik, Elizabeth A Weber, Jordan Tarshis
Administration of preoperative antimicrobial prophylaxis, often with a cephalosporin, is the mainstay of surgical site infection prevention guidelines. Unfortunately, due to prevalent misconceptions, patients labeled as having a penicillin allergy often receive alternate and less-effective antibiotics, placing them at risk of a variety of adverse effects including increased morbidity and higher risk of surgical site infection. The perioperative physician should ascertain the nature of previous reactions to aid in determining the probability of the prevalence of a true allergy...
May 10, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29757493/egg-yolk-provides-th2-adjuvant-stimuli-and-promotes-sensitization-to-egg-white-allergens-in-balb-c-mice
#11
Alba Pablos-Tanarro, Daniel Lozano-Ojalvo, Mónica Martínez-Blanco, Elena Molina, Rosina López-Fandiño
SCOPE: Egg is the second most frequent source of allergic reactions in children. Egg yolk (EY) amounts to one third in weight of a fresh whole egg, but its contribution to egg allergy has not been investigated in depth. This study assesses whether EY influences the capacity of egg white (EW) to sensitize and trigger allergic responses. METHODS AND RESULTS: BALB/c mice were exposed to EW, EY and their mixture, using models of orally (with and without adjuvant) and adjuvant-free intraperitoneally-induced allergy...
May 14, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29751365/the-interplay-between-risk-and-preventive-factors-explains-why-some-children-develop-allergies-to-certain-foods-and-others-show-tolerance
#12
REVIEW
Sami Remes, Petri Kulmala
AIM: A number of studies have clarified the tolerance mechanisms and risk factors for food allergies. Our aim was to explore food allergy symptoms by target organs, together with the risk factors and how to prevent food allergies and induce tolerance. METHODS: We carried out a thorough review of studies on paediatric food allergies published in the last decade. RESULTS: Food allergy symptoms may affect the skin, nasal and oral mucosa, conjunctivae, gastrointestinal tract, or, in severe cases, the respiratory tract and cardiovascular organs...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29751153/the-health-and-economic-outcomes-of-peanut-allergy-management-practices
#13
Marcus Shaker, Matthew Greenhawt
BACKGROUND: Peanut allergy is managed with strict avoidance, epinephrine carriage, and promptly treating reactions. OBJECTIVES: Assess the health and economic benefits of pre-emptively injecting epinephrine for peanut ingestion in the absence of any symptoms, and avoiding products with peanut precautionary allergen labeling (PAL). METHODS: We used Markov modeling and simulations, assuming a base-case 10-fold fatality risk increase for less conservative management, with sensitivity analysis investigating 100-1,000-fold increased fatality risk, incorporating risks of accidental exposures, reactions, fatality, and family costs of food allergy...
May 8, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29750772/the-ins-and-outs-of-an-outside-in-view-of-allergies-atopic-dermatitis-and-allergy-prevention
#14
Marcus Shaker, Robert G P Murray, Julianne A Mann
PURPOSE OF REVIEW: The skin barrier is a dynamic innate immune organ. This review summarizes the current understanding of how deficiencies associated with atopic dermatitis invite other atopic disorders of the allergic march. RECENT FINDINGS: Atopic dermatitis is characterized by skin barrier defects (such as mutations in filaggrin), intrinsic proallergic T-helper cell 2 immune dysregulation, and skin microbiome alterations. These factors promote the development of food allergy and asthma...
May 9, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29747472/combining-mucilair%C3%A2-and-vitrocell-%C3%A2-powder-chamber-for-the-in-vitro-evaluation-of-nasal-ointments-in-the-context-of-aerosolized-pollen
#15
Julia Metz, Katharina Knoth, Henrik Groß, Claus-Michael Lehr, Carolin Stäbler, Udo Bock, Marius Hittinger
Hay fever is notoriously triggered when nasal mucosa is exposed to allergenic pollen. One possibility to overcome this pollen exposure may be the application of an ointment with physical protective effects. In this context, we have investigated Bepanthen® Eye and Nose Ointment and the ointment basis petrolatum as reference while using contemporary in vitro techniques. Pollen from false ragweed ( Iva xanthiifolia ) was used as an allergy-causing model deposited as aerosol using the Vitrocell® Powder Chamber (VPC) on Transwell® inserts, while being coated with either Bepanthen® Eye and Nose Ointment and petrolatum...
May 10, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29745336/advances-in-the-management-of-food-allergy-in-children
#16
Stiefel Gary, Sadreddini Helyeh, Luyt David
Food allergy is common in children. An accurate diagnosis remains a key element in order to instigate an effective management plan. Traditional management strategies have relied on a reactive approach, with allergen avoidance, management of accidental ingestion and monitoring for resolution. Active management of food allergies relies on strategies to prevent food allergy through early introduction of allergenic foods and anticipatory testing. With an established food allergy diagnosis, active management through modifying the natural history, and risk management strategies can be instigated...
May 8, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29739682/multispecies-probiotics-combination-prevents-ovalbumin-induced-airway-hyperreactivity-in-mice
#17
Jui-Cheng Chen, Cheng-Chih Tsai, Chang-Chi Hsieh, Alice Lan, Chun-Chih Huang, Sew-Fen Leu
BACKGROUND: Probiotics could be beneficial to health and some of them have shown to modulate immune responses. AIM: The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model. METHODS: Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29739029/-systemic-corticosteroids-in-non-infectious-uveitis
#18
Thomas Neß
Corticosteroids are essential in the treatment of non-infectious uveitis, rheumatic diseases, autoimmune diseases, allergy, and in the therapy and prevention of transplant rejection. In addition to their beneficial effects, corticosteroids may have various adverse events, even with long-term use. Therefore, therapy with corticosteroids necessitates adequate dosing, monitoring and prophylaxis.
May 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29732363/human-milk-oligosaccharides-and-associations-with-immune-mediated-disease-and-infection-in-childhood-a-systematic-review
#19
Alice M Doherty, Caroline J Lodge, Shyamali C Dharmage, Xin Dai, Lars Bode, Adrian J Lowe
Complex sugars found in breastmilk, human milk oligosaccharides (HMOs), may assist in early-life immune programming and prevention against infectious diseases. This study aimed to systematically review the associations between maternal levels of HMOs and development of immune-mediated or infectious diseases in the offspring. PubMed and EMBASE databases were searched (last search on 22 February 2018) according to a predetermined search strategy. Original studies published in English examining the effect of HMOs on immune-mediated and infectious disease were eligible for inclusion...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29731005/molecular-aspects-of-allergens-and-allergy
#20
Rudolf Valenta, Alexander Karaulov, Verena Niederberger, Pia Gattinger, Marianne van Hage, Sabine Flicker, Birgit Linhart, Raffaela Campana, Margarete Focke-Tejkl, Mirela Curin, Julia Eckl-Dorna, Christian Lupinek, Yvonne Resch-Marat, Susanne Vrtala, Irene Mittermann, Victoria Garib, Musa Khaitov, Peter Valent, Winfried F Pickl
Immunoglobulin E (IgE)-associated allergy is the most common immune disorder. More than 30% of the population suffer from symptoms of allergy which are often severe, disabling, and life threatening such as asthma and anaphylaxis. Population-based birth cohort studies show that up to 60% of the world population exhibit IgE sensitization to allergens, of which most are protein antigens. Thirty years ago the first allergen-encoding cDNAs have been isolated. In the meantime, the structures of most of the allergens relevant for disease in humans have been solved...
2018: Advances in Immunology
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