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https://www.readbyqxmd.com/read/28340322/immunogenicity-and-safety-of-primary-and-booster-vaccination-with-2-investigational-formulations-of-diphtheria-tetanus-and-haemophilus-influenzae-type-b-antigens-in-a-hexavalent-dtpa-hbv-ipv-hib-combination-vaccine-in-comparison-with-the-licensed-infanrix-hexa
#1
Timo Vesikari, Luis Rivera, Tiina Korhonen, Anitta Ahonen, Brigitte Cheuvart, Marjan Hezareh, Winnie Janssens, Narcisa Mesaros
Safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and Haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis-Hib vaccine (DTPa-HBV-IPV/Hib) were evaluated in a Primary (NCT01248884) and a Booster vaccination (NCT01453998) study. In the Primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of DTPa-HBV-IPV/Hib formulation A (DATAPa-HBV-IPV/Hib), or B (DBTBPa-HBV-IPV/Hib) or the licensed DTPa-HBV-IPV/Hib vaccine (Infanrix hexa, GSK; control group) at 2, 3, 4 months of age...
March 24, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28283373/dynamics-affecting-the-risk-of-silent-circulation-when-oral-polio-vaccination-is-stopped
#2
J S Koopman, C J Henry, J H Park, M C Eisenberg, E L Ionides, J N Eisenberg
Waning immunity could allow transmission of polioviruses without causing poliomyelitis by promoting silent circulation (SC). Undetected SC when oral polio vaccine (OPV) use is stopped could cause difficult to control epidemics. Little is known about waning. To develop theory about what generates SC, we modeled a range of waning patterns. We varied both OPV and wild polio virus (WPV) transmissibility, the time from beginning vaccination to reaching low polio levels, and the infection to paralysis ratio (IPR)...
March 1, 2017: Epidemics
https://www.readbyqxmd.com/read/28274276/treatment-with-l-citrulline-in-patients-with-post-polio-syndrome-study-protocol-for-a-single-center-randomised-placebo-controlled-double-blind-trial
#3
Simone Schmidt, Vanya Gocheva, Thomas Zumbrunn, Daniela Rubino-Nacht, Ulrike Bonati, Dirk Fischer, Patricia Hafner
BACKGROUND: Post-polio syndrome (PPS) is a condition that affects polio survivors years after recovery from an initial acute infection by the Poliomyelitis virus. Most often, patients who suffered from polio start to experience gradual new weakening in muscles, a gradual decrease in the size of muscles (muscle atrophy) and fatigue years after the acute illness. L-citrulline is known to change muscular metabolism synthesis by raising nitric oxide (NO) levels and increasing protein synthesis...
March 9, 2017: Trials
https://www.readbyqxmd.com/read/28271089/total-knee-arthroplasty-in-severe-unstable-knee-case-report-and-literature-review
#4
Mohammad Naghi Tahmasebi, Gholamreza Ghorbani Amjad, Mohammad Hassan Kaseb, Kaveh Bashti
Multiplanar or global laxity in arthritic knee is rare, most of this patients have neuromuscular disorder (post poliomyelitis, spinal dystrophy) or history of knee trauma. Ligament insufficiency and severe bone loss is significant in this patient. The estimated prevalence for the concurrence of charcot marie-tooth (CMT) with myasthenia gravis (MG) suggests an extremely rare event. We have presented a 54-year-old female patient with CMT and MG complaining of progressive pain, swelling, and crepitation of the knee joints who had been undergone total knee arthroplasty (TKA) with rotating hinge prosthesis...
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28228112/three-case-reports-of-post-immunization-and-post-viral-bullous-pemphigoid-looking-for-the-right-trigger
#5
Luca Baroero, Paola Coppo, Laura Bertolino, Stefano Maccario, Francesco Savino
BACKGROUND: Bullous pemphigoid (BP) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. CASE PRESENTATION: Here we describe three cases of BP which were referred to our department in the last 15 years. Two of them developed an eruption of bullous lesions just a few days after vaccination for diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B and Haemophilus influenzae B. The third patient developed the same blistering lesions shortly after herpetic stomatitis...
February 23, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28215696/recurrent-venous-thrombosis-under-rivaroxaban-and-carbamazepine-for-symptomatic-epilepsy
#6
Claudia Stöllberger, Josef Finsterer
BACKGROUND: The direct oral anticoagulant (DOAC) rivaroxaban, an oral Factor Xa inhibitor, is increasingly used as an alternative to vitamin-K-antagonists (VKAs). Absorption and elimination of DOACs are dependent on the permeability glycoprotein (P-gp) efflux transporter protein system, and DOACs are substrates of the hepatic cytochrome P 450 3A4 (CYP3A4) enzymes. Therefore, drug-interactions may occur when DOACs are administered with drugs affecting the activity of P-gp or CYP3A4 systems...
February 3, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28187805/the-history-of-neurocritical-care
#7
E F M Wijdicks
Critical care medicine came into sharp focus in the second part of the 20th century. The care of acutely ill neurologic patients in the USA may have originated in postoperative neurosurgical units, but for many years patients with neurocritical illness were admitted to intensive care units next to patients with general medical or surgical conditions. Neurologists may have had their first exposure to the complexity of neurocritical care during the poliomyelitis epidemics, but few were interested. Much later, the development of neurocritical care as a legitimate subspecialty was possible as a result of a new cadre of neurologists, with support by departments of neurosurgery and anesthesia, who appreciated their added knowledge and expertise in care of acute neurologic illness...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28165878/vaccinations-in-migrants-and-refugees-a-challenge-for-european-health-systems-a-systematic-review-of-current-scientific-evidence
#8
REVIEW
Daniele Mipatrini, Paola Stefanelli, Santino Severoni, Giovanni Rezza
The decline of immunization rates in countries of origin of migrants and refugees, along with risky conditions during the journey to Europe, may threaten migrants' health. We performed a systematic review of the scientific literature in order to assess the frequency of vaccine preventable diseases, and vaccination coverage among migrants and refugees in Europe. To this end, Medline and Cochrane databases were considered. After the screening and the selection process, 58 papers were included in the review. We focused on the following vaccine-preventable diseases: hepatitis B, measles, rubella, mumps, tetanus, poliomyelitis, pertussis, diphtheria, meningitis, and varicella...
March 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28121284/knowledge-assessment-regarding-poliomyelitis-among-the-caregivers-of-children-who-received-oral-polio-vaccine-reveals-lack-of-awareness-of-the-vaccine-vial-monitor-vvm-implications-extending-beyond-polio-eradication
#9
Meenakshi Bhilwar, Panna Lal
Vaccine vial monitor (VVM) is now commonly used for vaccines that are included in the National Immunization Schedule in India. It helps to indicate the viability of the vaccine and of the proper functioning of the cold chain. This is useful as it prevents health personnel from administering damaged vaccine. Studies have shown a lack of awareness of health workers regarding the use and interpretation of a VVM. The current study, undertaken among the caregivers of children who were immunized, showed that this lack of information about the VVM also exists among the caregivers...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28117634/combined-tibial-lengthening-and-ankle-arthrodesis-for-patients-with-certain-type-of-sequelae-of-poliomyelitis
#10
Chi-Chuan Wu
PURPOSE: Following far advancement of modern medicine and technology, functional disability in a certain type of sequelae of poliomyelitis may be effectively improved. METHODS: Eight consecutive adult patients with unilateral sequelae of poliomyelitis were treated. These patients had shortened lower extremity of an average of 4.8 cm (range, 4.0-5.5 cm) in the lesion side. Muscle power of the ipsilateral knee was nearly intact (grade 4 or 5) but the ankle extension was completely flaccid...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28103317/genetically-thermo-stabilised-immunogenic-poliovirus-empty-capsids-a-strategy-for-non-replicating-vaccines
#11
Helen Fox, Sarah Knowlson, Philip D Minor, Andrew J Macadam
While wild type polio has been nearly eradicated there will be a need to continue immunisation programmes for some time because of the possibility of re-emergence and the existence of long term excreters of poliovirus. All vaccines in current use depend on growth of virus and most of the non-replicating (inactivated) vaccines involve wild type viruses known to cause poliomyelitis. The attenuated vaccine strains involved in the eradication programme have been used to develop new inactivated vaccines as production is thought safer...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28081056/guidance-for-assessment-of-poliovirus-vaccination-status-and-vaccination-of-children-who-have-received-poliovirus-vaccine-outside-the-united-states
#12
Mona Marin, Manisha Patel, Steve Oberste, Mark A Pallansch
In 1988, the World Health Assembly resolved to eradicate poliomyelitis (polio). Since then, wild poliovirus (WPV) cases have declined by >99.9%, from an estimated 350,000 cases of polio each year to 74 cases in two countries in 2015 (1). This decrease was achieved primarily through the use of trivalent oral poliovirus vaccine (tOPV), which contains types 1, 2, and 3 live, attenuated polioviruses. Since 2000, the United States has exclusively used inactivated polio vaccine (IPV), which contains all three poliovirus types (2,3)...
January 13, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28059613/seroprevalence-of-poliovirus-antibodies-in-the-kansas-city-metropolitan-area-2012-2013
#13
Gregory S Wallace, Barbara A Pahud, William C Weldon, Aaron T Curns, M Steven Oberste, Christopher J Harrison
No indigenous cases of poliomyelitis have occurred in the U.S. since 1979; however the risk of importation persists until global eradication is achieved. The seropositivity rate for different age cohorts with exposures to different poliovirus vaccine types and wild virus in the U.S. are not presently known. A convenience sample was conducted in the Kansas City metropolitan area during 2012-2103 with approximately 100 participants enrolled for each of 5 age cohorts categorized based on vaccine policy changes over time in the U...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28057194/budget-impact-of-polio-immunization-strategy-for-india-introduction-of-one-dose-of-inactivated-poliomyelitis-vaccine-and-reductions-in-supplemental-polio-immunization
#14
M M Khan, S Sharma, B Tripathi, F P Alvarez
OBJECTIVES: To conduct a budget impact analysis (BIA) of introducing the immunization recommendations of India Expert Advisory Group (IEAG) for the years 2015-2017. The recommendations include introduction of one inactivated poliomyelitis vaccine (IPV) dose in the regular child immunization programme along with reductions in oral polio vaccine (OPV) doses in supplemental programmes. STUDY DESIGN: This is a national level analysis of budget impact of new polio immunization recommendations...
January 2017: Public Health
https://www.readbyqxmd.com/read/28057103/-inactivated-poliovirus-vaccines-an-inevitable-choice-for-eliminating-poliomyelitis
#15
J D Vidor, Shu Jean-Denis
The inactivated poliovirus vaccine (IPV) is a very old tool in the fight against poliomyelitis. Though supplanted by oral poliovirus vaccine (OPV) in the 1960s and 1970s, the IPV has now become an inevitable choice because of the increasingly recognized risks associated with continuous use of OPVs. Following the pioneering work of Jonas Salk, who established key principles for the IPV, considerable experience has accumulated over the years. This work has led to modern Salk IPV-containing vaccines, based on the use of inactivated wildtype polioviruses, which have been deployed for routine use in many countries...
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28039136/laboratory-surveillance-of-polio-and-other-enteroviruses-in-high-risk-populations-and-environmental-samples
#16
Vasiliki Pogka, Stavroula Labropoulou, Mary Emmanouil, Androniki Voulgari-Kokota, Alexandra Vernardaki, Theano Georgakopoulou, Andreas F Mentis
In the context of poliomyelitis eradication, a reinforced supplementary laboratory surveillance of enteroviruses was implemented in Greece. Between 2008 and 2014, the Hellenic Polioviruses/Enteroviruses Reference Laboratory performed detailed supplementary surveillance of circulating enteroviruses among healthy individuals in high-risk population groups, among immigrants from countries in which poliovirus is endemic, and in environmental samples. In total, 722 stool samples and 179 sewage water samples were included in the study...
March 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28038948/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2017-recommendations
#17
David Moreno-Pérez, Francisco José Álvarez García, Javier Arístegui Fernández, María José Cilleruelo Ortega, José María Corretger Rauet, Nuria García Sánchez, Ángel Hernández Merino, Teresa Hernández-Sampelayo Matos, Manuel Merino Moína, Luis Ortigosa Del Castillo, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV- AEP) annually publishes the immunisation schedule which, in our opinion, is considered optimal for children resident in Spain, taking into account the evidence available on current vaccines. Pneumococcal and varicella immunisation in early childhood is already included in all funded vaccines present in the regional immunisation programmes. Furthermore, this committee establishes recommendations on vaccines not included in official calendars (non-funded immunisations), such as rotavirus, meningococcal B, and meningococcal ACWY...
February 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28035545/dtap5-hb-ipv-hib-vaccine-vaxelis-%C3%A2-a-review-of-its-use-in-primary-and-booster-vaccination
#18
Yahiya Y Syed
Vaxelis(®) is a fully liquid, ready-to-use, hexavalent vaccine approved in the EU for primary and booster vaccination in infants and toddlers from the age of 6 weeks against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive diseases caused by Haemophilus influenzae type b (Hib). It contains diphtheria and tetanus toxoids, five acellular pertussis antigens, recombinant hepatitis B virus surface antigen produced in the yeast, Saccharomyces cerevisiae, inactivated poliovirus, and the Hib polysaccharide (polyribosylribitol phosphate) conjugated to the outer membrane protein complex of Neisseria meningitidis...
February 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28030524/attitudes-of-swiss-health-care-providers-towards-childhood-immunizations
#19
Marianne Schuler, Sabine Schaedelin, Christoph Aebi, Christoph Berger, Pierre-Alex Crisinel, Alessandro Diana, Anita Niederer-Loher, Claire-Anne Siegrist, Bernard Vaudaux, Ulrich Heininger
BACKGROUND: INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers towards the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. METHODS: In March 2015, a web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary...
December 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28000111/uncommon-disorders-masquerading-as-acute-flaccid-paralysis-in-children
#20
Meenal Garg, Shilpa D Kulkarni, Varsha Patil, Rafat Sayed, Anaita Udwadia Hegde
The syndrome of acute flaccid paralysis (AFP) is a common medical emergency in children. In the era of poliomyelitis eradication, the common causes of AFP include Guillain-Barré syndrome (GBS), transverse myelitis and traumatic neuritis. However, many common diseases can uncommonly present as AFP and some uncommon diseases may also masquerade like it. Uncommon causes of AFP seen at a tertiary care pediatric hospital are discussed along with relevant points in diagnosis and management. Also, common pitfalls in diagnosis of pediatric AFP and an approach to investigations are discussed...
December 21, 2016: Indian Journal of Pediatrics
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