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https://www.readbyqxmd.com/read/28419204/immune-serum-from-sabin-inactivated-poliovirus-vaccine-immunization-neutralizes-multiple-individual-wild-and-vaccine-derived-polioviruses
#1
Mingbo Sun, Changgui Li, Wenbo Xu, Guoyang Liao, Rongcheng Li, Jian Zhou, Yanping Li, Wei Cai, Dongmei Yan, Yanchun Che, Zhifang Ying, Jianfeng Wang, Huijuan Yang, Yan Ma, Lei Ma, Guang Ji, Li Shi, Shude Jiang, Qihan Li
Background.: A Sabin strain-based inactivated poliomyelitis vaccine (Sabin-IPV) is the rational option for completely eradicating poliovirus transmission. The neutralizing capacity of Sabin-IPV immune serum to different strains of poliovirus is a key indicator of the clinical protective efficacy of this vaccine. Methods.: Sera collected from 500 infants enrolled in a randomized, blinded, positive control, phase 2 clinical trial were randomly divided into 5 groups: Groups A, B, and C received high, medium, and low doses, respectively, of Sabin-IPV, while groups D and E received trivalent oral polio vaccine and Salk strain-based IPV, respectively, all on the same schedule...
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28409290/comparison-of-clinical-and-laboratory-characteristics-during-two-major-paediatric-meningitis-outbreaks-of-echovirus-30-and-other-non-polio-enteroviruses-in-germany-in-2008-and-2013
#2
H Rudolph, R Prieto Dernbach, M Walka, P Rey-Hinterkopf, V Melichar, E Muschiol, S Schweitzer-Krantz, J W Richter, C Weiss, S Böttcher, S Diedrich, H Schroten, T Tenenbaum
Viral meningitis is mainly caused by non-polio enteroviruses (NPEV). Large-scale data on the clinical characteristics between different outbreaks within the same region are lacking. This study aimed to analyse a possible influence of the circulating NPEV genotype on the disease outcome of affected children. A retrospective cohort study analysing two major outbreaks of NPEV meningitis in Germany in 2008 and 2013 was conducted in cooperation with the National Reference Centre for Poliomyelitis and Enteroviruses (NRC PE) and five German children's hospitals...
April 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28390186/acute-flaccid-paralysis-surveillance-in-bosnia-and-herzegovina-recent-isolation-of-two-sabin-like-type-2-poliovirus
#3
Stefano Fontana, Gabriele Buttinelli, Stefano Fiore, Mirsada Mulaomerovic, Jela Aćimović, Concetta Amato, Roberto Delogu, Giovanni Rezza, Paola Stefanelli
The WHO Regional Commission for the Certification of Poliomyelitis Eradication has recently indicated Bosnia and Herzegovina (B&H) as a high risk country for transmission, following importation, of wild poliovirus (WPV) or circulating vaccine-derived poliovirus (cVDPV). We analyzed data on Acute Flaccid Paralysis (AFP) surveillance between 2007 to 2016, and the trend of polio immunization coverage in B&H. The majority of AFP cases was recorded in 2016 suggesting an enhancement of the AFP surveillance activities...
April 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28387112/175-performance-of-acute-flaccid-paralysis-afp-surveillance-and-incidence-of-poliomyelitis-2017
#4
(no author information available yet)
No abstract text is available yet for this article.
April 7, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/28380696/long-term-neuromuscular-outcomes-of-west-nile-virus-infection-a-clinical-and-electromyograph-evaluation-of-patients-with-a-history-of-infection
#5
Parveen Athar, Rodrigo Hasbun, Melissa N Garcia, Lucrecia Salazar, Steven Woods, Kazim Sheikh, Kristy O Murray
INTRODUCTION: Neuromuscular clinical manifestations during acute West Nile virus (WNV) infection are well documented; however, long-term neurological outcomes still require investigation. METHODS: We conducted a long-term follow up study in patients with history of WNV infection. Out of 117 patients who participated in neurologic and neurocognitive evaluations, 30 patients were referred for neuromuscular and electrodiagnostic evaluation based on abnormal findings...
April 5, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28362135/immunogenicity-and-safety-evaluation-of-bivalent-types-1-and-3-oral-poliovirus-vaccine-by-comparing-different-poliomyelitis-vaccination-schedules-in-china-a-randomized-controlled-non-inferiority-clinical-trial
#6
Jingjun Qiu, Yunkai Yang, Lirong Huang, Ling Wang, Zhiwei Jiang, Jian Gong, Wei Wang, Hongyan Wang, Shaohong Guo, Chanjuan Li, Shuyuan Wei, Zhaojun Mo, Jielai Xia
BACKGROUND: The type 2 component of the oral poliovirus vaccine is targeted for global withdrawal through a switch from the trivalent oral poliovirus vaccine (tOPV) to a bivalent oral poliovirus vaccine (bOPV). The switch is intended to prevent paralytic polio caused by circulating vaccine-derived poliovirus type 2. We aimed to assess the immunogenicity and safety profile of 6 vaccination schedules with different sequential doses of inactivated poliovirus vaccine (IPV), tOPV, or bOPV...
March 1, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28361789/vaccine-associated-paralytic-poliomyelitis-unmasking-common-variable-immunodeficiency
#7
Sunil Gomber, Vanny Arora, Pooja Dewan
BACKGROUND: Oral polio vaccine can rarely lead to Vaccine-associated paralytic poliomyelitis (VAPP). CASE CHARACTERISTICS: A 2-year-old child with asymmetric paralysis of lower limbs following first booster of oral polio vaccine; type 2 Vaccine-derived poliovirus (VDPV) isolated. Subsequently, the child was diagnosed to have common variable immunodeficiency. OUTCOME: Paralysis gradually improved on follow-up; monthly intravenous immunoglobulin therapy started for primary immunodeficiency...
March 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28357974/immunisation-status-and-determinants-of-left-behind-children-aged-12-72-months-in-central-china
#8
Z L Ni, X D Tan, H Y Shao, Y Wang
Many parents move from rural China to urban areas in search of job opportunities, and leave their children behind to be raised by relatives. We aimed to assess the immunisation coverage, including the 1:3:3:3:1 vaccine series (one dose of Bacilli Chalmette-Guérin vaccine; three doses of live attenuated oral poliomyelitis vaccine; three doses of diphtheria, tetanus and pertussis combined; three doses of hepatitis B vaccine; and one dose of measles-containing vaccine), in children aged 12-72 months and identify the determinants of immunisation uptake among left-behind children in Hubei Province, Central China, in 2014...
March 30, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28356537/pathogenic-events-in-a-nonhuman-primate-model-of-oral-poliovirus-infection-leading-to-paralytic-poliomyelitis
#9
Ling Shen, Crystal Y Chen, Dan Huang, Richard Wang, Meihong Zhang, Lixia Qian, Yanfen Zhu, Alvin Zhuoran Zhang, Enzhuo Yang, Arwa Qaqish, Konstantin Chumakov, Diana Kouiavskaia, Marco Vignuzzi, Neal Nathanson, Andrew J Macadam, Raul Andino, Olen Kew, Junfa Xu, Zheng W Chen
Despite a great deal of prior research, the early pathogenic events in natural oral poliovirus infection remain poorly defined. To establish a model for study, we infected 39 macaques by feeding single high doses of the virulent Mahoney strain of wild type 1 poliovirus. Doses ranging from10(7)-10(9) TCID50 consistently infected all animals, and most monkeys receiving 10(8) or 10(9) TCID50 developed paralysis. There was no apparent difference in the susceptibility of the three macaque species (rhesus, cynomolgus, and bonnet) used...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28355321/assessment-of-energy-expenditure-in-individuals-with-post-poliomyelitis-syndrome
#10
Roberto Dias Batista Pereira, Tatiana Mesquita E Silva, Abrahão Augusto Juviniano Quadros, Marco Orsini, Beny Schmidt, Helga Cristina Almeida Silva, Acary Souza Bulle Oliveira
Methods: The Baecke questionnaire for the evaluation of habitual physical activity (HPA), assessment of quality of life (WHOQOL-Bref), and the Fatigue Severity Scale were administered to patients with PPS, poliomyelitis sequelae (PS) and to a control group (CG). Participated in the study 116 individuals (PPS=52,PS= 28,CG=36). Results: Patients with PPS tended to increase their HPA from 10 to 20 years of age, compared with those in the PS group and the CG. In the period from 21 to 30 years of age, there was significant increase in the PPS group's occupational physical activity compared to the PS group, and the occupational physical activity (21-30 years of age) correlated with the onset of symptoms of PPS...
March 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28350511/design-construction-and-evaluation-of-sensor-lock-an-electromechanical-stance-control-knee-joint
#11
Mokhtar Arazpour, Monireh Ahmadi Bani, Mina Baniasad, Mohammad Samadian, Navid Golchin
BACKGROUND AND AIM: Most currently-available stance control knee ankle foot orthoses (SCKAFOs) still need full knee extension to lock the knee joint, and they are still noisy, bulky, and heavy. Therefore, the aim of this study was to design, construct, and evaluate an original electromechanical SCKAFO knee joint that could feasibly solve these problems, and thus address the problems of current stance control knee joints with regards to their structure, function, cosmesis, and cost. METHOD: Ten able-bodied (AB) participants and two (knee ankle foot orthosis) KAFO users were recruited to participate in the study...
March 28, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28348941/cutting-the-stone-health-defined-in-the-era-of-value-based-care
#12
REVIEW
Ger Rijkers
The immune system contributes to the maintenance of health by preventing and limiting the clinical consequences of infections by pathogenic microorganisms. During the evolution of Homo sapiens, those with the fittest immune system survived. The immune system of Homo sapiens was further improved and adapted by admixture with Neanderthal genes. Nowadays, the human immune system provides adequate protection against the majority of infections. For some 20 infectious diseases, the immune system needs to be improved by vaccination...
February 10, 2017: Curēus
https://www.readbyqxmd.com/read/28340322/immunogenicity-and-safety-of-primary-and-booster-vaccination-with-2-investigational-formulations-of-diphtheria-tetanus-and-haemophilus-influenzae-type-b-antigens-in-a-hexavalent-dtpa-hbv-ipv-hib-combination-vaccine-in-comparison-with-the-licensed-infanrix-hexa
#13
Timo Vesikari, Luis Rivera, Tiina Korhonen, Anitta Ahonen, Brigitte Cheuvart, Marjan Hezareh, Winnie Janssens, Narcisa Mesaros
Safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and Haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis-Hib vaccine (DTPa-HBV-IPV/Hib) were evaluated in a Primary (NCT01248884) and a Booster vaccination (NCT01453998) study. In the Primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of DTPa-HBV-IPV/Hib formulation A (DATAPa-HBV-IPV/Hib), or B (DBTBPa-HBV-IPV/Hib) or the licensed DTPa-HBV-IPV/Hib vaccine (Infanrix hexa, GSK; control group) at 2, 3, 4 months of age...
March 24, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28283373/dynamics-affecting-the-risk-of-silent-circulation-when-oral-polio-vaccination-is-stopped
#14
J S Koopman, C J Henry, J H Park, M C Eisenberg, E L Ionides, J N Eisenberg
Waning immunity could allow transmission of polioviruses without causing poliomyelitis by promoting silent circulation (SC). Undetected SC when oral polio vaccine (OPV) use is stopped could cause difficult to control epidemics. Little is known about waning. To develop theory about what generates SC, we modeled a range of waning patterns. We varied both OPV and wild polio virus (WPV) transmissibility, the time from beginning vaccination to reaching low polio levels, and the infection to paralysis ratio (IPR)...
March 1, 2017: Epidemics
https://www.readbyqxmd.com/read/28274276/treatment-with-l-citrulline-in-patients-with-post-polio-syndrome-study-protocol-for-a-single-center-randomised-placebo-controlled-double-blind-trial
#15
Simone Schmidt, Vanya Gocheva, Thomas Zumbrunn, Daniela Rubino-Nacht, Ulrike Bonati, Dirk Fischer, Patricia Hafner
BACKGROUND: Post-polio syndrome (PPS) is a condition that affects polio survivors years after recovery from an initial acute infection by the Poliomyelitis virus. Most often, patients who suffered from polio start to experience gradual new weakening in muscles, a gradual decrease in the size of muscles (muscle atrophy) and fatigue years after the acute illness. L-citrulline is known to change muscular metabolism synthesis by raising nitric oxide (NO) levels and increasing protein synthesis...
March 9, 2017: Trials
https://www.readbyqxmd.com/read/28271089/total-knee-arthroplasty-in-severe-unstable-knee-case-report-and-literature-review
#16
Mohammad Naghi Tahmasebi, Gholamreza Ghorbani Amjad, Mohammad Hassan Kaseb, Kaveh Bashti
Multiplanar or global laxity in arthritic knee is rare, most of this patients have neuromuscular disorder (post poliomyelitis, spinal dystrophy) or history of knee trauma. Ligament insufficiency and severe bone loss is significant in this patient. The estimated prevalence for the concurrence of charcot marie-tooth (CMT) with myasthenia gravis (MG) suggests an extremely rare event. We have presented a 54-year-old female patient with CMT and MG complaining of progressive pain, swelling, and crepitation of the knee joints who had been undergone total knee arthroplasty (TKA) with rotating hinge prosthesis...
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28228112/three-case-reports-of-post-immunization-and-post-viral-bullous-pemphigoid-looking-for-the-right-trigger
#17
Luca Baroero, Paola Coppo, Laura Bertolino, Stefano Maccario, Francesco Savino
BACKGROUND: Bullous pemphigoid (BP) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. CASE PRESENTATION: Here we describe three cases of BP which were referred to our department in the last 15 years. Two of them developed an eruption of bullous lesions just a few days after vaccination for diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B and Haemophilus influenzae B. The third patient developed the same blistering lesions shortly after herpetic stomatitis...
February 23, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28215696/recurrent-venous-thrombosis-under-rivaroxaban-and-carbamazepine-for-symptomatic-epilepsy
#18
Claudia Stöllberger, Josef Finsterer
BACKGROUND: The direct oral anticoagulant (DOAC) rivaroxaban, an oral Factor Xa inhibitor, is increasingly used as an alternative to vitamin-K-antagonists (VKAs). Absorption and elimination of DOACs are dependent on the permeability glycoprotein (P-gp) efflux transporter protein system, and DOACs are substrates of the hepatic cytochrome P 450 3A4 (CYP3A4) enzymes. Therefore, drug-interactions may occur when DOACs are administered with drugs affecting the activity of P-gp or CYP3A4 systems...
March 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28187805/the-history-of-neurocritical-care
#19
E F M Wijdicks
Critical care medicine came into sharp focus in the second part of the 20th century. The care of acutely ill neurologic patients in the USA may have originated in postoperative neurosurgical units, but for many years patients with neurocritical illness were admitted to intensive care units next to patients with general medical or surgical conditions. Neurologists may have had their first exposure to the complexity of neurocritical care during the poliomyelitis epidemics, but few were interested. Much later, the development of neurocritical care as a legitimate subspecialty was possible as a result of a new cadre of neurologists, with support by departments of neurosurgery and anesthesia, who appreciated their added knowledge and expertise in care of acute neurologic illness...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28165878/vaccinations-in-migrants-and-refugees-a-challenge-for-european-health-systems-a-systematic-review-of-current-scientific-evidence
#20
REVIEW
Daniele Mipatrini, Paola Stefanelli, Santino Severoni, Giovanni Rezza
The decline of immunization rates in countries of origin of migrants and refugees, along with risky conditions during the journey to Europe, may threaten migrants' health. We performed a systematic review of the scientific literature in order to assess the frequency of vaccine preventable diseases, and vaccination coverage among migrants and refugees in Europe. To this end, Medline and Cochrane databases were considered. After the screening and the selection process, 58 papers were included in the review. We focused on the following vaccine-preventable diseases: hepatitis B, measles, rubella, mumps, tetanus, poliomyelitis, pertussis, diphtheria, meningitis, and varicella...
March 2017: Pathogens and Global Health
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