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https://www.readbyqxmd.com/read/27933548/metabolic-characterization-of-acutely-isolated-hippocampal-and-cerebral-cortical-slices-using-u-13-c-glucose-and-1-2-13-c-acetate-as-substrates
#1
Laura F McNair, Rasmus Kornfelt, Anne B Walls, Jens V Andersen, Blanca I Aldana, Jakob D Nissen, Arne Schousboe, Helle S Waagepetersen
Brain slice preparations from rats, mice and guinea pigs have served as important tools for studies of neurotransmission and metabolism. While hippocampal slices routinely have been used for electrophysiology studies, metabolic processes have mostly been studied in cerebral cortical slices. Few comparative characterization studies exist for acute hippocampal and cerebral cortical slices, hence, the aim of the current study was to characterize and compare glucose and acetate metabolism in these slice preparations in a newly established incubation design...
December 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27933359/raccoons-procyon-lotor-as-sentinels-of-trace-element-contamination-and-physiological-effects-of-exposure-to-coal-fly-ash
#2
Felipe Hernández, Ricki E Oldenkamp, Sarah Webster, James C Beasley, Lisa L Farina, Samantha M Wisely
Anthropogenic pollutants disrupt global biodiversity, and terrestrial sentinels of pollution can provide a warning system for ecosystem-wide contamination. This study sought to assess whether raccoons (Procyon lotor) are sentinels of local exposure to trace element contaminants at a coal fly ash site and whether exposure resulted in health impairment or changes in the intestinal helminth communities. We compared trace element accumulation and the impact on health responses and intestinal helminth communities of raccoons inhabiting contaminated and reference sites of the U...
December 8, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27933288/health-complaints-associated-with-poor-rental-housing-conditions-in-arkansas-the-only-state-without-a-landlord-s-implied-warranty-of-habitability
#3
Ashley E Bachelder, M Kate Stewart, Holly C Felix, Neil Sealy
Arkansas is the only U.S. state that does not have a landlord's implied warranty of habitability, meaning tenants have a requirement for maintaining their rental properties at certain habitability standards, but landlords are not legally required to contribute to those minimum health and safety standards. This project assessed the possibility that this lack of landlord responsibility affects tenants' perceived health. Using surveys and interviews, we collected self-reported data on the prevalence and description of problems faced by renters who needed household repairs from their landlords...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27933254/characterization-of-a-novel-hatching-enzyme-purified-from-starfish-asterina-pectinifera
#4
Ji Hoon Choi, Sang Moo Kim
Hatching enzyme is a protease which can degrade the membrane of egg. In this study, a hatching enzyme was purified from starfish (Asterina pectinifera) with 6.34 fold of purification rate, 5.04 % of yield, and 73.87 U/mg of specific activity. The molecular weight of starfish hatching enzyme was 86 kDa, which was reduced to 62 kDa after removal of N-linked oligosaccharides. The optimal pH and temperature of the hatching enzyme activity were pH 7.0 and 40 °C, respectively, while those of stability were pH 8 and 20 °C...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933233/isolation-and-characterisation-of-crude-oil-sludge-degrading-bacteria
#5
Linda U Obi, Harrison I Atagana, Rasheed A Adeleke
BACKGROUND: The use of microorganisms in remediating environmental contaminants such as crude oil sludge has become a promising technique owing to its economy and the fact it is environmentally friendly. Polycyclic aromatic hydrocarbons (PAHs), as the major components of oil sludge, are hydrophobic and recalcitrant. An important way of enhancing the rate of PAH desorption is to compost crude oil sludge by incorporating commercial surfactants, thereby making them available for microbial degradation...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27932948/rna-editing-systemic-relevance-and-clue-to-disease-mechanisms
#6
REVIEW
Jochen C Meier, Svenja Kankowski, Heinz Krestel, Florian Hetsch
Recent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with diseases such as atherosclerosis, myopathy, epilepsy, major depression disorder, schizophrenia and other mental disorders as well as cancer and brain tumors. This review article summarizes our current knowledge on that front and presents glycine receptor C-to-U RNA editing as a first example of disease-associated increased RNA editing that includes assessment of disease mechanisms of the corresponding gene product in an animal model...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27932498/harnessing-molecular-motors-for-nanoscale-pulldown-in-live-cells
#7
Jonathan E Bird, Melanie Barzik, Meghan C Drummond, Daniel C Sutton, Spencer M Goodman, Eva L Morozko, Stacey M Cole, Alexandra K Boukhvalova, Jennifer Skidmore, Diana Syam, Elizabeth A Wilson, Tracy Fitzgerald, Atteeq U Rehman, Donna M Martin, Erich T Boger, Inna A Belyantseva, Thomas B Friedman
Protein-protein interactions (PPIs) regulate assembly of macromolecular complexes, yet these remain challenging to study within the native cytoplasm where they normally exert their biological effect. Here, we miniaturize the concept of affinity pulldown, a gold-standard in vitro PPI interrogation technique, to perform nanoscale pulldowns (NanoSPD) within living cells. NanoSPD hijacks the normal process of intracellular trafficking by myosin motors to forcibly pull fluorescently-tagged protein complexes along filopodial actin filaments...
December 8, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27932298/modeling-birds-on-wires
#8
A Aydoğdu, P Frasca, C D'Apice, R Manzo, J M Thornton, B Gachomo, T Wilson, B Cheung, U Tariq, W Saidel, B Piccoli
In this paper we introduce a mathematical model to study the group dynamics of birds resting on wires. The model is agent-based and postulates attraction-repulsion forces between the interacting birds: the interactions are "topological", in the sense that they involve a given number of neighbors irrespective of their distance. The model is first mathematically analyzed and then simulated to study its main properties: we observe that the model predicts birds to be more widely spaced near the borders of each group...
December 5, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27932282/serum-cardiac-troponin-i-in-canine-syncope-and-seizures
#9
E Dutton, J Dukes-McEwan, P J Cripps
OBJECTIVE: To determine if serum cardiac troponin I (cTnI) concentration distinguishes between cardiogenic syncope and collapsing dogs presenting with either generalized epileptic seizures (both with and without cardiac disease) or vasovagal syncope. ANIMALS: Seventy-nine prospectively recruited dogs, grouped according to aetiology of collapse: generalized epileptic seizures (group E), cardiogenic syncope (group C), dogs with both epileptic seizures and cardiac disease (group B), vasovagal syncope (group V) or unclassified (group U)...
December 5, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27932137/quality-of-life-according-to-urgency-status-in-de-novo-heart-transplant-recipients
#10
B Díaz-Molina, J L Lambert, F G Vílchez, F Cadenas, M J Bernardo, E Velasco, M Martín, C Morís
INTRODUCTION: Elective heart transplantation (HTX) aims to improve physical ability, increase survival, and improve health-related quality of life (HRQoL) in patients with chronic heart failure. Nevertheless, most patients who undergo urgent HTX are previously healthy, and a transplant could be perceived as a limitation. The aim of this study is to compare HRQoL between elective and urgent heart transplant recipients. METHODS: Cohort study including patients undergoing heart transplantation between January 1998 and March 2012 in a single center...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932098/urinary-clara-cell-protein-in-kidney-transplant-patients-a-preliminary-study
#11
P M García-García, E Martín-Izquierdo, C M-F de Basoa, A Jarque-López, G Pérez-Suárez, A Rivero-González, J M González-Posadas, M Macía-Heras, V M García-Nieto, J F Navarro-Gónzález
OBJECTIVE: The aim of this exploratory study was to analyze the urinary excretion of Clara cell protein (CC16), a new marker of proximal tubular dysfunction (PTD), in kidney transplantation (KT). MATERIALS AND METHODS: Urinary concentrations of CC16, β2-microglobulin (β2m), and N-acetyl-glucosaminidase (NAG) were measured in 50 KT patients (72% men; mean age 50.4 ± 12.4 years; diabetes in 24%; duration of KT 4.3 ± 3.1 years) and 10 healthy controls (6 men; mean age 33...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932040/embryonic-exposure-to-model-naphthenic-acids-delays-growth-and-hatching-in-the-pond-snail-lymnaea-stagnalis
#12
Christina U Johnston, Lindsay N Clothier, Dean M Quesnel, Lisa M Gieg, Gordon Chua, Petra M Hermann, Willem C Wildering
Naphthenic acids (NAs), a class of structurally diverse carboxylic acids with often complex ring structures and large aliphatic tail groups, are important by-products of many petrochemical processes including the oil sands mining activity of Northern Alberta. While it is evident that NAs have both acute and chronic harmful effects on many organisms, many aspects of their toxicity remain to be clarified. Particularly, while substantive data sets have been collected on NA toxicity in aquatic prokaryote and vertebrate model systems, to date, nothing is known about the toxic effects of these compounds on the embryonic development of aquatic invertebrate taxa, including freshwater mollusks...
December 5, 2016: Chemosphere
https://www.readbyqxmd.com/read/27931563/brazilian-healthcare-professionals-a-study-of-attitudes-toward-organ-donation
#13
C Araujo, M Siqueira
BACKGROUND: Healthcare professionals have a crucial role in organ donation and transplantation processes. Their attitude toward organ donation can affect public opinion and the donation decision made by deceased donors' relatives. The objectives of the study were to analyze the attitude of medical and nursing personnel toward deceased organ donation in two hospitals in Rio de Janeiro, Brazil, and the factors that can affect this attitude. METHODS: A random sample (n = 162) was selected from the population of nurses and physicians in the hospitals analyzed...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931267/western-diet-in-the-perinatal-period-promotes-dysautonomia-in-the-offspring-of-adult-rats
#14
R Vidal-Santos, F N Macedo, M N S Santana, V U De Melo, J L de Brito Alves, M R V Santos, L C Brito, E Nascimento, J H Costa-Silva, V J Santana-Filho
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother's diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram...
December 9, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27930966/nonsuicidal-self-injury-and-interpersonal-violence-in-u-s-veterans-seeking-help-for-posttraumatic-stress-disorder
#15
Patrick S Calhoun, Elizabeth E Van Voorhees, Eric B Elbogen, Eric A Dedert, Carolina P Clancy, Lauren P Hair, Michael Hertzberg, Jean C Beckham, Nathan A Kimbrel
Nonsuicidal self-injury (NSSI) has been defined as deliberately damaging one's body tissue without conscious suicidal intent. NSSI is a robust predictor of suicidal ideation and attempts in adults. While NSSI has been associated with other-directed violence in adolescent populations, the link between NSSI and interpersonal violence in adults is less clear. The current study examined the cross-sectional relationship between NSSI and past-year interpersonal violence among 729 help-seeking veterans with posttraumatic stress disorder (PTSD)...
November 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27930716/mre11-and-atm-expression-levels-predict-rectal-cancer-survival-and-their-association-with-radiotherapy-response
#16
Vincent Ho, Liping Chung, Maxine Revoltar, Stephanie H Lim, Thein-Ga Tut, Askar Abubakar, Chris J Henderson, Wei Chua, Weng Ng, Mark Lee, Paul De Souza, Matthew Morgan, C Soon Lee, Joo-Shik Shin
BACKGROUND: Aberrant expression of DNA repair proteins is associated with poor survival in cancer patients. We investigated the combined expression of MRE11 and ATM as a predictive marker of response to radiotherapy in rectal cancer. METHODS: MRE11 and ATM expression were examined in tumor samples from 262 rectal cancer patients who underwent surgery for rectal cancer, including a sub-cohort of 54 patients who were treated with neoadjuvant radiotherapy. The relationship between expression of the two-protein panel and tumor regression grade (TRG) was assessed by Mann-Whitney U test and receiver operating characteristics area under curve (ROC-AUC) analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27930565/a-case-report-with-the-peculiar-concomitance-of-2-different-genetic-syndromes
#17
Alberto Lerario, Irene Colombo, Donatella Milani, Lorenzo Peverelli, Luisa Villa, Roberto Del Bo, Monica Sciacco, Giacomo Pietro Comi, Susanna Esposito, Maurizio Moggio
RATIONALE: Down syndrome (DS) is the most common chromosome disorder in live born infants, affecting several body systems, but usually sparing skeletal muscles. We present the case of a child with coexistence of DS and dystrophinopathy. Only 1 similar case has been reported so far. PATIENT CONCERNS: An 8-year-old boy with DS had a history of incidental finding of increased serum creatine kinase levels up to 1775 U/L (normal values 38-174 U/L). He presented no delay in motor development; at the neurological examination, no muscle weakness or fatigability was detected in 2 different evaluations performed over a 6-month period...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930472/risks-associated-with-lentiviral-vector-exposures-and-prevention-strategies
#18
Ryan Schlimgen, John Howard, Dawn Wooley, Maureen Thompson, Lindsey R Baden, Otto O Yang, David C Christiani, Gustavo Mostoslavsky, David V Diamond, Elizabeth Gilman Duane, Karen Byers, Thomas Winters, Jeffrey A Gelfand, Gary Fujimoto, T Warner Hudson, Jatin M Vyas
Lentiviral vectors (LVVs) are powerful genetic tools that are being used with greater frequency in biomedical laboratories and clinical trials. Adverse events reported from initial clinical studies provide a basis for risk assessment of occupational exposures, yet many questions remain about the potential harm that LVVs may cause. We review those risks and provide a framework for principal investigators, Institutional Biosafety Committees, and occupational health professionals to assess and communicate the risks of exposure to staff...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27929270/sexually-transmitted-infections-recommendations-from-the-u-s-preventive-services-task-force
#19
Karen C Lee, Quyen Ngo-Metzger, Tracy Wolff, Joya Chowdhury, Michael L LeFevre, David S Meyers
The U.S. Preventive Services Task Force (USPSTF) has issued recommendations on behavioral counseling to prevent sexually transmitted infections (STIs) and recommendations about screening for individual STIs. Clinicians should obtain a sexual history to assess for behaviors that increase a patient's risk. Community and population risk factors should also be considered. The USPSTF recommends intensive behavioral counseling for all sexually active adolescents and for adults whose history indicates an increased risk of STIs...
December 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928886/f376a-m388a-solulin-a-new-promising-antifibrinolytic-for-severe-haemophilia-a
#20
J Parcq, K U Petersen, A Borel-Derlon, P Gautier, M Ebel, D Vivien, Y Repessé
INTRODUCTION: Haemophilia is a major bleeding disorder due to a deficiency of procoagulant factor VIII (type A) or IX (type B). The treatment is substitutive and based on infusion of factor concentrates. Main limitations of this therapy are cost, short factor half-life and the development of inhibitors (up to 30% of severe HA patients). An important aggravating factor of haemophilia is due to a premature fibrinolysis, directing attention to the therapeutic potential of suitable antifibrinolytics...
December 8, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
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