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https://www.readbyqxmd.com/read/28538727/establishment-and-cryptic-transmission-of-zika-virus-in-brazil-and-the-americas
#1
N R Faria, J Quick, I M Claro, J Thézé, J G de Jesus, M Giovanetti, M U G Kraemer, S C Hill, A Black, A C da Costa, L C Franco, S P Silva, C-H Wu, J Raghwani, S Cauchemez, L du Plessis, M P Verotti, W K de Oliveira, E H Carmo, G E Coelho, A C F S Santelli, L C Vinhal, C M Henriques, J T Simpson, M Loose, K G Andersen, N D Grubaugh, S Somasekar, C Y Chiu, J E Muñoz-Medina, C R Gonzalez-Bonilla, C F Arias, L L Lewis-Ximenez, S A Baylis, A O Chieppe, S F Aguiar, C A Fernandes, P S Lemos, B L S Nascimento, H A O Monteiro, I C Siqueira, M G de Queiroz, T R de Souza, J F Bezerra, M R Lemos, G F Pereira, D Loudal, L C Moura, R Dhalia, R F França, T Magalhães, E T Marques, T Jaenisch, G L Wallau, M C de Lima, V Nascimento, E M de Cerqueira, M M de Lima, D L Mascarenhas, J P Moura Neto, A S Levin, T R Tozetto-Mendoza, S N Fonseca, M C Mendes-Correa, F P Milagres, A Segurado, E C Holmes, A Rambaut, T Bedford, M R T Nunes, E C Sabino, L C J Alcantara, N J Loman, O G Pybus
Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 2016) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 2016). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28538723/genomic-epidemiology-reveals-multiple-introductions-of-zika-virus-into-the-united-states
#2
Nathan D Grubaugh, Jason T Ladner, Moritz U G Kraemer, Gytis Dudas, Amanda L Tan, Karthik Gangavarapu, Michael R Wiley, Stephen White, Julien Thézé, Diogo M Magnani, Karla Prieto, Daniel Reyes, Andrea M Bingham, Lauren M Paul, Refugio Robles-Sikisaka, Glenn Oliveira, Darryl Pronty, Carolyn M Barcellona, Hayden C Metsky, Mary Lynn Baniecki, Kayla G Barnes, Bridget Chak, Catherine A Freije, Adrianne Gladden-Young, Andreas Gnirke, Cynthia Luo, Bronwyn MacInnis, Christian B Matranga, Daniel J Park, James Qu, Stephen F Schaffner, Christopher Tomkins-Tinch, Kendra L West, Sarah M Winnicki, Shirlee Wohl, Nathan L Yozwiak, Joshua Quick, Joseph R Fauver, Kamran Khan, Shannon E Brent, Robert C Reiner, Paola N Lichtenberger, Michael J Ricciardi, Varian K Bailey, David I Watkins, Marshall R Cone, Edgar W Kopp, Kelly N Hogan, Andrew C Cannons, Reynald Jean, Andrew J Monaghan, Robert F Garry, Nicholas J Loman, Nuno R Faria, Mario C Porcelli, Chalmers Vasquez, Elyse R Nagle, Derek A T Cummings, Danielle Stanek, Andrew Rambaut, Mariano Sanchez-Lockhart, Pardis C Sabeti, Leah D Gillis, Scott F Michael, Trevor Bedford, Oliver G Pybus, Sharon Isern, Gustavo Palacios, Kristian G Andersen
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28535619/prevalence-and-incidence-of-osteoporotic-fractures-in-patients-on-long-term-glucocorticoid-treatment-for-rheumatic-diseases-the-glucocorticoid-induced-osteoporosis-tool-giotto-study
#3
M Rossini, O Viapiana, M Vitiello, N Malavolta, G La Montagna, S Maddali Bongi, O Di Munno, R Nuti, C U Manzini, C Ferri, L Bogliolo, A Mathieu, F Cantatore, A Del Puente, M Muratore, W Grassi, B Frediani, G Saviola, P Delvino, L Mirone, G Ferraccioli, G Tripi, I Piazza, D Gatti
Osteoporosis and fractures are common and invalidating consequences of chronic glucorticoid (GC) treatment. Reliable information regarding the epidemiology of GC induced osteoporosis (GIOP) comes exclusively from the placebo group of randomized clinical trials while observational studies are generally lacking data on the real prevalence of vertebral fractures, GC dosage and primary diagnosis. The objective of this study was to evaluate the prevalence and incidence of osteoporotic fractures and to identify their major determinants (primary disease, GC dosage, bone mineral density, risk factors, specific treatment for GIOP) in a large cohort of consecutive patients aged >21 years, on chronic treatment with GC (≥5 mg prednisone - PN - equivalent) and attending rheumatology centers located all over Italy...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28535380/development-of-an-international-comorbidity-education-framework
#4
C Lawson, S Pati, J Green, G Messina, A Strömberg, N Nante, D Golinelli, A Verzuri, S White, T Jaarsma, P Walsh, P Lonsdale, U T Kadam
CONTEXT: The increasing number of people living with multiple chronic conditions in addition to an index condition has become an international healthcare priority. Health education curricula have been developed alongside single condition frameworks in health service policy and practice and need redesigning to incorporate optimal management of multiple conditions. AIM: Our aims were to evaluate current teaching and learning about comorbidity care amongst the global population of healthcare students from different disciplines and to develop an International Comorbidity Education Framework (ICEF) for incorporating comorbidity concepts into health education...
May 17, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28535184/maternal-zika-virus-disease-severity-virus-load-prior-dengue-antibodies-and-their-relationship-to-birth-outcomes
#5
U A Halai, K Nielsen-Saines, M E Moreira, P C Sequeira, J P Pereira Junior, A A Zin, J D Cherry, C R Gabaglia, S L Gaw, K Adachi, I Tsui, J H Pilotto, R M Ribeiro Nogueira, A M Bispo de Filippis, P Brasil
Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement and duration of symptoms during ZIKV infection...
May 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28535151/correlations-of-hemoglobin-level-and-perioperative-blood-transfusion-with-the-prognosis-of-gastric-cancer-a-retrospective-study
#6
Gang Wu, Dai-Yang Zhang, Yu-Han Duan, Ying-Qiong Zhang, Xian-Nian Cui, Zheng Luo
BACKGROUND This study was designed to explore the correlations of hemoglobin level (Hb) and perioperative blood transfusion with the prognosis of gastric cancer (GC). MATERIAL AND METHODS Our study consisted of 210 patients with GC who all received a D2 radical operation. These patients were assigned into three groups: 68 cases in group A (blood transfusion >5 U); 59 cases in group B (blood transfusion <5 U); 83 cases in group C (without blood transfusion). A 5-year follow-up was conducted to evaluate the disease-free survival of the patients...
May 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28534058/freezability-of-water-buffalo-spermatozoa-is-improved-with-the-addition-of-catalase-in-cryodiluent
#7
L Ali, S M Hassan Andrabi, H Ahmed, A A Hussain Shah
BACKGROUND: Catalase enzyme is usually distributed in mammalian seminal plasma, where it decomposes hydrogen peroxide into water and oxygen and enhances sperm survivability. OBJECTIVE: To evaluate the effect of catalase (0, 100, 200 or 300 IU/ml) added in tris-citric acid (TCA) based extender on motion characteristics, viability and DNA integrity of bubaline spermatozoa at post dilution (PD) and post thawing (PT) stages of cryopreservation. MATERIALS AND METHODS: Collection of semen was done in four Nili-Ravi bulls with an artificial vagina (42 degree C)...
March 2017: Cryo Letters
https://www.readbyqxmd.com/read/28533828/evaluation-of-preference-and-purpose-of-utilisation-of-cone-beam-computed-tomography-cbct-compared-to-orthopantomogram-opg-by-dental-practitioners-a-cross-sectional-study
#8
Komali Garlapati, D B Gandhi Babu, Nallan C S K Chaitanya, Harika Guduru, Anusha Rembers, Pratima Soni
BACKGROUND: Cone beam computed tomography (CBCT) has become a reliable adjunctive tool for both diagnosis and treatment planning in the field of dentistry. There are numerous advantages of CBCT over 2D imaging techniques (OPG). There is a need to evaluate the changing trend of preference and purpose of utilisation of these imaging modalities by dental practitioners. This study was carried out to evaluate and compare the purpose and preference of utilisation of CBCT and OPG by various dental practitioners in their clinical practice...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28533252/national-trends-in-prescription-drug-expenditures-and-projections-for-2017
#9
Glen T Schumock, Edward C Li, Michelle D Wiest, Katie J Suda, JoAnn Stubbings, Linda M Matusiak, Robert J Hunkler, Lee C Vermeulen
PURPOSE: Historical trends and factors likely to influence future pharmaceutical expenditures are discussed, and projections are made for drug spending in 2017 in nonfederal hospitals, clinics, and overall (all sectors). METHODS: Drug expenditure data through calendar year 2016 were obtained from the QuintilesIMS National Sales Perspectives database and analyzed. Other factors that may influence drug spending in hospitals and clinics in 2017, including new drug approvals and patent expirations, were also reviewed...
May 22, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28532941/cataract-surgery-practices-in-the-united-states-veterans-health-administration
#10
Annika G Havnaer, Paul B Greenberg, Glenn C Cockerham, Melissa A Clark, Amy Chomsky
PURPOSE: To describe current cataract surgery practices within the United States Veterans Health Administration (VHA). SETTING: Veterans Health Administration hospitals in the U.S. DESIGN: Retrospective data analysis. METHODS: An initial e-mail containing a link to an anonymous 32-question survey of cataract surgery practices was sent to participants in May 2016. Two reminder e-mails were sent to nonresponders 1 week and 2 weeks after the initial survey was sent; the remaining nonresponders were called twice over a 2-week period...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28532148/gluten-free-sources-of-fermentable-extract-effect-of-temperature-and-germination-time-on-quality-attributes-of-teff-eragrostis-tef-zucc-trotter-malt-and-wort
#11
Lidia Di Ghionno, Eung Gwan Lee, Ombretta Marconi, Christopher J Rice, Valeria Sileoni, Giuseppe Perretti
This study was conducted to evaluate the behavior of a white teff variety called Witkop during malting by using different parameters (germination temperature and duration) and to identify the best malting program. Samples were evaluated for standard quality malt and wort attributes, pasting characteristics, β-glucan and arabinoxylan content and sugar profile. It was concluded that malting teff at 24°C for 6 days produced acceptable malt in terms of quality attributes and sugar profile for brewing. The main attributes were: 80...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28531966/how-do-disturbances-and-climate-effects-on-carbon-and-water-fluxes-differ-between-multi-aged-and-even-aged-coniferous-forests
#12
Xuguang Tang, Hengpeng Li, Mingguo Ma, Li Yao, Matthias Peichl, Altaf Arain, Xibao Xu, Michael Goulden
Disturbances and climatic changes significantly affect forest ecosystem productivity, water use efficiency (WUE) and carbon (C) flux dynamics. A deep understanding of terrestrial feedbacks to such effects and recovery mechanisms in forests across contrasting climatic regimes is essential to predict future regional/global C and water budgets, which are also closely related to the potential forest management decisions. However, the resilience of multi-aged and even-aged forests to disturbances has been debated for >60years because of technical measurement constraints...
May 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531651/synthesis-and-characterization-of-au-nps-supported-on-carbon-nanotubes-application-for-the-ultrasound-assisted-removal-of-radioactive-uo2-2-ions-following-complexation-with-arsenazo-iii-spectrophotometric-detection-optimization-isotherm-and-kinetic-study
#13
Mohammad Hassan Omidi, Farshid Nasiri Azad, Mehrorang Ghaedi, Arash Asfaram, Mohammad Hossein Ahmadi Azqhandi, Lobat Tayebi
The present study devoted to description of efficient removal of radioactive UO2(2+) ions (U(IV)) via complexation with Arsenazo III (ARS III) accelerated by ultrasound-assisted adsorption onto the Au-NPs supported on carbon nanotubes (Au-NPs-CNTs), which were characterized by conventional techniques such as FESEM, EDS and XRD. Central composite design (CCD) employed to model contribution of parameters viz. pH (2.5-8.5), adsorbent mass (5-25mg), UO2(2+) concentration (5-25mgL(-1)) and sonication time (1-5min) onto response...
May 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28530525/cost-effectiveness-of-nivolumab-ipilimumab-combination-therapy-compared-with-monotherapy-for-first-line-treatment-of-metastatic-melanoma-in-the-united-states
#14
Anna Oh, Dang M Tran, Leann C McDowell, Dor Keyvani, Jay Andrew Barcelon, Oscar Merino, Leslie Wilson
BACKGROUND: The approval of new immunotherapies has dramatically changed the treatment landscape of metastatic melanoma. These survival gains come with trade-offs in side effects and costs, as well as important considerations for third-party payer systems, physicians, and patients. OBJECTIVE: To develop a Markov model to determine the cost-effectiveness of nivolumab, ipilimumab, and nivolumab-ipilimumab combination as firstline therapy in metastatic melanoma, while accounting for differential effectiveness in programmed death-ligand 1 (PD-L1) positive and negative patients...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28529875/advanced-magnetic-resonance-imaging-and-neuropsychological-assessment-for-detecting-brain-injury-in-a-prospective-cohort-of-university-amateur-boxers
#15
M G Hart, C R Housden, J Suckling, R Tait, A Young, U Müller, V F J Newcombe, I Jalloh, B Pearson, J Cross, R A Trivedi, J D Pickard, B J Sahakian, P J Hutchinson
BACKGROUND/AIM: The safety of amateur and professional boxing is a contentious issue. We hypothesised that advanced magnetic resonance imaging and neuropsychological testing could provide evidence of acute and early brain injury in amateur boxers. METHODS: We recruited 30 participants from a university amateur boxing club in a prospective cohort study. Magnetic resonance imaging (MRI) and neuropsychological testing was performed at three time points: prior to starting training; within 48 h following a first major competition to detect acute brain injury; and one year follow-up...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529773/crystal-structures-of-isomeric-3-5-di-chloro-n-2-3-di-methyl-phen-yl-benzene-sulfonamide-3-5-di-chloro-n-2-6-di-methyl-phen-yl-benzene-sulfonamide-and-3-5-di-chloro-n-3-5-di-methyl-phen-yl-benzene-sulfonamide
#16
K Shakuntala, S Naveen, N K Lokanath, P A Suchetan
The crystal structures of three isomeric compounds of formula C14H13Cl2NO2S, namely 3,5-di-chloro-N-(2,3-di-methyl-phen-yl)-benzene-sulfonamide (I), 3,5-di-chloro-N-(2,6-di-methyl-phen-yl)benzene-sulfonamide (II) and 3,5-di-chloro-N-(3,5-di-methyl-phen-yl)benzene-sulfonamide (III) are described. The mol-ecules of all the three compounds are U-shaped with the two aromatic rings inclined at 41.3 (6)° in (I), 42.1 (2)° in (II) and 54.4 (3)° in (III). The mol-ecular conformation of (II) is stabilized by intra-molecular C-H⋯O hydrogen bonds and C-H⋯π inter-actions...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28528906/warts-signaling-controls-organ-and-body-growth-through-regulation-of-ecdysone
#17
Morten E Moeller, Stanislav Nagy, Stephan U Gerlach, Karen C Soegaard, E Thomas Danielsen, Michael J Texada, Kim F Rewitz
Coordination of growth between individual organs and the whole body is essential during development to produce adults with appropriate size and proportions [1, 2]. How local organ-intrinsic signals and nutrient-dependent systemic factors are integrated to generate correctly proportioned organisms under different environmental conditions is poorly understood. In Drosophila, Hippo/Warts signaling functions intrinsically to regulate tissue growth and organ size [3, 4], whereas systemic growth is controlled via antagonistic interactions of the steroid hormone ecdysone and nutrient-dependent insulin/insulin-like growth factor (IGF) (insulin) signaling [2, 5]...
May 17, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28528810/titration-of-intravenous-oxytocin-infusion-for-postdate-induction-of-labor-across-body-mass-index-groups
#18
Angela B Maeder, Susan C Vonderheid, Chang G Park, Aleeca F Bell, Barbara L McFarlin, Catherine Vincent, C Sue Carter
OBJECTIVE: To evaluate whether oxytocin titration for postdate labor induction differs among women who are normal weight, overweight, and obese and whether length of labor and birth method differ by oxytocin titration and body mass index (BMI). DESIGN: Retrospective cohort study. SETTING: U.S. university-affiliated hospital. PARTICIPANTS: Of 280 eligible women, 21 were normal weight, 134 were overweight, and 125 were obese at labor admission...
May 18, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28528678/the-effect-of-structured-patient-education-on-physical-activity-in-patients-with-peripheral-arterial-disease-and-intermittent-claudication-a-systematic-review
#19
REVIEW
U O Abaraogu, P M Dall, C A Seenan
OBJECTIVES: The aim was review the components and effects of patient education interventions to improve physical activity (PA) in patients with peripheral arterial disease (PAD) and intermittent claudication (IC), and patients' experiences of these interventions. DATA SOURCES: CINAHL, Cochrane Library, Ovid, ProQuest, AMED, MEDLINE, PsycINFO, Web of Science Core Collection, and PEDRO, and Trial registers and directory of Open Access repository websites and Web of science conference proceedings were searched...
May 18, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28528188/the-impact-of-perioperative-fluid-therapy-on-short-term-outcomes-and-5-year-survival-among-patients-undergoing-colorectal-cancer-surgery%C3%A2-a-prospective-cohort-study-within-an-eras-protocol
#20
D Asklid, J Segelman, C Gedda, F Hjern, K Pekkari, U O Gustafsson
BACKGROUND: Restricted perioperative fluid therapy is one of several interventions in the enhanced recovery after surgery (ERAS) protocol, designed to reduce morbidity and hospital stay after surgery. The impact of this single intervention on short and long term outcome after colorectal surgery is unknown. PATIENTS AND METHODS: This cohort study includes all consecutive patients operated with abdominal resection of colorectal cancer 2002-2007 at Ersta Hospital, Stockholm, Sweden...
May 3, 2017: European Journal of Surgical Oncology
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