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https://www.readbyqxmd.com/read/29898819/disorganization-and-real-world-functioning-in-schizophrenia-results-from-the-multicenter-study-of-the-italian-network-for-research-on-psychoses
#1
P Rocca, S Galderisi, A Rossi, A Bertolino, P Rucci, D Gibertoni, C Montemagni, S Bellino, E Aguglia, M Amore, A Bellomo, M Biondi, B Carpiniello, A Cuomo, E D'Ambrosio, L dell'Osso, P Girardi, C Marchesi, P Monteleone, C Montemitro, L Oldani, F Pacitti, R Roncone, A Siracusano, E Tenconi, A Vita, P Zeppegno, L Steardo, A Vignapiano, M Maj
BACKGROUND: A general consensus has not yet been reached regarding the role of disorganization symptoms in real-world functioning in schizophrenia. METHODS: We used structural equations modeling (SEM) to analyze the direct and indirect associations between disorganization and real-world functioning assessed through the Specific Levels of Functioning Scale (SLOF) in 880 subjects with schizophrenia. RESULTS: We found that: 1) conceptual disorganization was directly and strongly connected with SLOF daily activities; difficulty in abstract thinking was associated with moderate strength to all SLOF domains, and poor attention was connected with SLOF work skills; 2) grandiosity was only related with poor work skills, and delusions were associated with poor functioning in all SLOF domains; interpersonal relationships were weakly indirectly influenced by hallucinatory behavior, delusions and unusual thought contents through the mediation of social cognition (SC); 3) among the negative symptoms, avolition had only direct links with SLOF work skills and SLOF activities; anhedonia had direct links with SLOF work skills and SLOF interpersonal and indirect link with SLOF work skills through functional capacity (FC); asociality with SLOF interpersonal; blunted affect had direct links with SLOF activities and indirect links with SLOF interpersonal relationships mediated by SC...
June 10, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29895533/characterization-of-heterozygous-htra1-mutations-in-taiwanese-patients-with-cerebral-small-vessel-disease
#2
Yi-Chung Lee, Chin-Ping Chung, Nai-Chen Chao, Jong-Ling Fuh, Feng-Chi Chang, Bing-Wing Soong, Yi-Chu Liao
BACKGROUND AND PURPOSE: Homozygous and compound heterozygous mutations in the high temperature requirement serine peptidase A1 gene ( HTRA1 ) cause cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy. However, heterozygous HTRA1 mutations were recently identified to be associated with autosomal dominant cerebral small vessel disease (SVD). The present study aims at investigating the clinical features, frequency, and spectrum of HTRA1 mutations in a Taiwanese cohort with SVD...
June 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29888994/impact-of-psychosis-in-bipolar-disorder-during-manic-episodes
#3
Elionor Nehme, Sahar Obeid, Souheil Hallit, Chadia Haddad, Wael Salame, Fouad Tahan
OBJECTIVES: To evaluate the effect of psychosis on prognosis as measured by the course of a manic episode, symptoms severity and time to remission and identify existing differences in positive and negative symptoms between psychotic and non-psychotic patients. STUDY DESIGN: 40 bipolar patients presenting with a diagnosis of acute mania were enrolled (18 psychotic patients and 22 non psychotic patients) in this cross-sectional study. Subjects were required to complete two self-reported questionnaires, the Young Mania Rating Scale (YMRS) for manic symptoms, and Positive and Negative Symptoms Scale (PANSS) for psychotic symptoms...
June 11, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29883776/persecutory-delusions-effects-of-cognitive-bias-modification-for-interpretation-and-the-maudsley-review-training-programme-on-social-anxiety-jumping-to-conclusions-belief-inflexibility-and-paranoia
#4
James Hurley, Jo Hodgekins, Sian Coker, David Fowler
BACKGROUND AND OBJECTIVES: The Threat Anticipation Model (Freeman, 2007) implicates social anxiety, jumping to conclusions (JTC) and belief inflexibility in persecutory delusions. We investigated whether Cognitive Bias Modification for Interpretation (CBM-I; Turner et al., 2011) improves social anxiety by targeting negative interpretation bias of ambiguous social information. We determined whether the Maudsley Review Training Programme (MRTP; Waller et al., 2011) improves JTC, belief inflexibility and paranoia...
May 9, 2018: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29872665/visual-hallucinations-and-paranoid-delusions
#5
R C Hamdy, A Kinser, Tracey Kendall-Wilson, A Depelteau, R Copeland, K Whalen, J Culp
Visual well-formed hallucinations, fluctuations in the level of cognition, and alertness and extrapyramidal signs are core features of dementia with Lewy bodies. Some patients realize that what they are seeing or hearing are just hallucinations and learn to accept them. Others, however experience these hallucinations as quite real and cannot be dissuaded from the firm belief that they are. In fact, efforts to dissuade them often serve only to confirm the often associated paranoid delusions and this may lead to a catastrophic ending...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29871707/remission-of-depression-in-patients-with-schizophrenia-and-comorbid-major-depressive-disorder-results-from-the-face-sz-cohort
#6
Guillaume Fond, Laurent Boyer, Fabrice Berna, Ophélia Godin, Ewa Bulzacka, Méja Andrianarisoa, Lore Brunel, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Nathalie Coulon, Thierry D'Amato, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Sylvain Leignier, Christophe Lançon, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Franck Schürhoff, Pierre-Michel Llorca
BACKGROUND: Major depressive disorder (MDD) is underdiagnosed and undertreated in schizophrenia, and has been strongly associated with impaired quality of life.AimsTo determine the prevalence and associated factors of MDD and unremitted MDD in schizophrenia, to compare treated and non-treated MDD. METHOD: Participants were included in the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment. MDD was defined by a Calgary score ≥6...
June 6, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29867752/cortical-brain-changes-in-patients-with-locked-in-syndrome-experiencing-hallucinations-and-delusions
#7
Marco Sarà, Riccardo Cornia, Massimiliano Conson, Antonio Carolei, Simona Sacco, Francesca Pistoia
Previous evidence suggests that hallucinations and delusions may be detected in patients with the most severe forms of motor disability including locked-in syndrome (LIS). However, such phenomena are rarely described in LIS and their presence may be underestimated as a result of the severe communication impairment experienced by the patients. In this study, we retrospectively reviewed the clinical history and the neuroimaging data of a cohort of patients with LIS in order to recognize the presence of hallucinations and delusions and to correlate it with the pontine damage and the presence of any cortical volumetric changes...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29867603/management-of-patients-who-make-threats-against-elected-officials-a-case-report
#8
Paulina Riess, Luisa Gonzalez, Panagiota Korenis
Federal law makes it a crime to threaten the President of the United States. The Secret Service conducts thousands of violence risk assessments each year. Literature suggests that 75% of individuals who make threats have been diagnosed with a mental illness (1). Studies show that prominent symptoms in presidential assassins include persecutory and grandiose delusions, hence falling into the category of psychotic disorders. We present a case of a patient diagnosed with Schizoaffective Disorder brought to CPEP (Comprehensive Psychiatric Emergency Program) by the Secret Service for repeatedly dialing 911 and making threats to the President...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29863689/-psychopathology-and-phenomenology-of-religious-delusion-of-possession-in-schizophrenia
#9
G I Kopeyko, O A Borisova, E V Gedevani
AIM: To analyze psychopathological features of religious delusion of possession, determine the place of this phenomenon in psychotic syndrome, and identify the prognosis and dynamics of schizophrenia due to this disorder. MATERIAL AND METHODS: Thirteen patients with religious delusion of possession were examined in 1994-2016 by psychopathological and follow-up methods. RESULTS AND CONCLUSION: Hallucinations of a general feeling are the crucial psychopathological phenomenon of states with religious delusion of possession...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29862345/data-gathering-ability-contributes-to-visual-organization-and-probabilistic-reasoning
#10
Tyler Bernadyn, Keith A Feigenson
Individuals use data gathering methods to inform judgments and behaviors. Effective interaction with the environment depends on these having high accuracy and low noise, but when they become abnormal, aberrant thoughts and perceptions can occur. In this study, we examined if data gathering methods were consistent across tasks that relied on different cognitive abilities, specifically visual perception and probabilistic reasoning. Thirty-four non-clinical participants engaged in the Ebbinghaus Illusion and the Jumping to Conclusions tasks, while also completing questionnaires concerning aspects of delusion formation...
March 2018: Heliyon
https://www.readbyqxmd.com/read/29859117/gabaergic-deficits-and-schizophrenia-like-behaviors-in-a-mouse-model-carrying-patient-derived-neuroligin-2-r215h-mutation
#11
Dong-Yun Jiang, Zheng Wu, Cody Tieu Forsyth, Yi Hu, Siu-Pok Yee, Gong Chen
Schizophrenia (SCZ) is a severe mental disorder characterized by delusion, hallucination, and cognitive deficits. We have previously identified from schizophrenia patients a loss-of-function mutation Arg215 →His215 (R215H) of neuroligin 2 (NLGN2) gene, which encodes a cell adhesion molecule critical for GABAergic synapse formation and function. Here, we generated a novel transgenic mouse line with neuroligin-2 (NL2) R215H mutation. The single point mutation caused a significant loss of NL2 protein in vivo, reduced GABAergic transmission, and impaired hippocampal activation...
June 1, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29851148/the-influence-of-the-individual-neuropsychiatric-symptoms-of-people-with-alzheimer-disease-on-family-caregiver-distress-a-longitudinal-alsova-study
#12
Ilona Hallikainen, Anne M Koivisto, Tarja Välimäki
OBJECTIVES: Family caregivers (FCs) face a variety of demands while caring for persons with Alzheimer disease (AD). Longitudinal studies identifying the specific AD-related neuropsychiatric symptoms (NPS) that contribute to FC distress are rare. We analyzed which NPS in association with care recipient and caregiver demographic factors are associated with FC psychological distress over a 36-month follow-up period. DESIGN: This is a longitudinal study with annual follow-up...
May 30, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29843964/latent-toxoplasma-infection-in-real-world-schizophrenia-results-from-the-national-face-sz-cohort
#13
G Fond, L Boyer, F Schürhoff, F Berna, O Godin, E Bulzacka, M Andrianarisoa, L Brunel, B Aouizerate, D Capdevielle, I Chereau, N Coulon, T D'Amato, C Dubertret, J Dubreucq, C Faget, C Lançon, S Leignier, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, P M Llorca, M Leboyer, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, N Coulon, J M Danion, T D'Amato, A Deloge, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, M Jarroir, S Leignier, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, P M Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, A M Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, A Zinetti-Bertschy
OBJECTIVE: Latent Toxoplasma infection has been associated with widespread brain immune activation, increased blood brain barrier permeability, neural disruption, increased dopamine release in dopaminergic neurons, with NMDA activation and with schizophrenia (SZ) onset risk. Toxoplasma has been suggested to be a source of chronic low-grade inflammation and this inflammation has been associated with cognitive impairment in SZ. The objective of the present study were (i) to determine if latent Toxoplasma infection was associated with specific clinical features in stabilized SZ subjects, with cognitive impairment and with increased low-grade peripheral inflammation and (ii) to determine if Treatments with Anti-Toxoplasmic Activity (TATA) were associated with improved outcomes in subjects with latent Toxoplasma infection...
May 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29803209/antipsychotics-in-hyperthyroid-related-psychosis-case-report-and-systematic-review
#14
Danielle Golub, Victor Rodack
OBJECTIVES: Hyperthyroidism has been associated with relatively rare presentations of psychotic symptoms. We report an example of the successful use of antipsychotics to manage psychotic symptoms in hyperthyroid-related psychosis. Furthermore, we systematically describe the available literature on the use of antipsychotics in this setting to determine the associated relative efficacies of the various antipsychotic agents. METHODS: Presentation of a case of hyperthyroid-related psychosis treated with an antipsychotic agent followed by a systematic review of all similar cases: PubMed, Ovid MEDLINE and PMC were searched for articles published between 1960 and 2017 that report on the use of specific antipsychotics in the management of hyperthyroid-related psychosis...
March 27, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29802811/mirtazapine-adjunct-for-people-with-schizophrenia
#15
REVIEW
Luke A Perry, Dhruvesh Ramson, Suzanne Stricklin
BACKGROUND: Many individuals who have a diagnosis of schizophrenia experience a range of distressing and debilitating symptoms. These can include positive symptoms (such as delusions, hallucinations, disorganised speech), cognitive symptoms (such as trouble focusing or paying attention or using information to make decisions), and negative symptoms (such as diminished emotional expression, avolition, alogia, and anhedonia). Antipsychotic drugs are often only partially effective, particularly in treating negative symptoms, indicating the need for additional treatment...
May 26, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29792050/risk-of-psychosis-in-recurrent-episodes-of-psychotic-and-nonpsychotic-major-depressive-disorder-a-systematic-review-and-meta-analysis
#16
J Craig Nelson, David Bickford, Kevin Delucchi, Jess G Fiedorowicz, William H Coryell
OBJECTIVE: The authors conducted a systematic review and meta-analysis to determine whether the risk of psychosis is higher in past or future episodes in patients with major depression with psychotic features than in patients with nonpsychotic depression. METHOD: PubMed, Embase, and PsycINFO were searched, and studies were selected that 1) identified patients with unipolar major depression, 2) made diagnoses of psychosis based on the presence of delusions or hallucinations, 3) characterized past or subsequent episodes as psychotic or nonpsychotic, and 4) were published in English...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29790849/-n-methyl-d-aspartate-receptor-antibody-encephalitis-the-janus-faced-disorder
#17
Ildiko Sipos
The recognition of the antibody-mediated encephalitis as a separate entity among the immune disorders of the central nervous system was one of the greatest breakthroughs of the last two decades in neurology. Unlike viral or tumor-related encephalitis, the antibody-mediated form has a good response to immunotherapy, which gives a special clinical importance to the discovery. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one of the first fully characterized antibody-mediated encephalitises. This article attempts to summarize the clinical features of this complex neuropsychiatric disorder with the aim to help its early recognition and to report the clinical course and the outcome of our six seropositive anti-NMDAR cases...
March 2018: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/29766653/organic-psychosis-the-pathobiology-and-treatment-of-delusions
#18
REVIEW
Eileen Maria Joyce
Organic or secondary psychosis can be seen in diverse conditions such as toxic/metabolic disorders, neurodegenerative disease, and stroke. Poststroke psychosis is a rare phenomenon, but its study has significantly contributed to the understanding of delusion formation. The evidence from case studies of patients with focal strokes shows that delusions develop following unilateral damage of the right hemisphere. The majority of patients with right hemisphere stroke do not develop delusions however, and advanced neuroimaging analysis has elucidated why this symptom develops in only a small proportion...
May 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29755713/a-mobile-multimedia-reminiscence-therapy-application-to-reduce-behavioral-and-psychological-symptoms-in-persons-with-alzheimer-s
#19
Danish Imtiaz, Arshia Khan, Adriana Seelye
The goal of this project is to develop a novel and innovative mobile solution to address behavioral and psychological symptoms of dementia (BPSD) that occur in individuals with Alzheimer's. BPSD can include agitation, restlessness, aggression, apathy, obsessive-compulsive and repetitive behaviors, hallucinations, delusions, paranoia, and wandering. Alzheimer's currently affects 5.4 million adults in the United States and that number is projected to increase to 14 million by 2050. Almost 90% of all affected with AD experience BPSD, resulting in increased healthcare costs, heavier burden on caregivers, poor patient outcomes, early nursing home placement, long-term hospitalizations, and misuse of medications...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29754115/delusional-misidentifications-in-a-procrustean-bed
#20
EDITORIAL
G N Christodoulou, M Margariti, N Christodoulou
The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally fused functions of perception and recognition. The classical sub-types are: the syndromes of Capgras, Fregoli,Intermetamorphosis (mentioned in 3) and Subjective doubles. These syndromes occur in a clear sensorium and shouldbe differentiated from the banal transient misidentifications occurring in confusional states and in mania and from thenon-delusional misidentifications (e...
January 2018: Psychiatrikē, Psychiatriki
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