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(Generalized estimating equation) or GEE

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https://www.readbyqxmd.com/read/29775076/walking-with-controlled-breathing-improves-exercise-tolerance-anxiety-and-quality-of-life-in-heart-failure-patients-a-randomized-controlled-trial
#1
Hsiu-Chin Teng, Mei-Ling Yeh, Mei-Hua Wang
BACKGROUND: Patients with heart failure experience not only impaired physical condition, but also their physical activity, moods, and quality of life may be diminished. AIMS: The purpose of this study was to investigate the effects of 12-week walking with breathing program on physical activity tolerance considering time-dependent physiological factors and time-independent interoceptive awareness, as well as psychosocial factors. METHODS: This randomized controlled trial recruited 90 heart failure patients and randomly assigned them...
May 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29774193/predictable-values-of-decompressive-craniectomy-in-patients-with-acute-subdural-hematoma-comparison-between-decompressive-craniectomy-after-craniotomy-group-and-craniotomy-only-group
#2
Hyunjun Kim, Sang-Jun Suh, Ho-Jun Kang, Min-Seok Lee, Yoon-Soo Lee, Jeong-Ho Lee, Dong-Gee Kang
Objective: Patients with traumatic acute subdural hematoma (ASDH) often require surgical treatment. Among patients who primarily underwent craniotomy for the removal of hematoma, some consequently developed aggressive intracranial hypertension and brain edema, and required secondary decompressive craniectomy (DC). To avoid reoperation, we investigated factors which predict the requirement of DC by comparing groups of ASDH patients who did and did not require DC after craniotomy. Methods: The 129 patients with ASDH who underwent craniotomy from September 2007 to September 2017 were reviewed...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29773874/mutations-in-six-nephrosis-genes-delineate-a-pathogenic-pathway-amenable-to-treatment
#3
Shazia Ashraf, Hiroki Kudo, Jia Rao, Atsuo Kikuchi, Eugen Widmeier, Jennifer A Lawson, Weizhen Tan, Tobias Hermle, Jillian K Warejko, Shirlee Shril, Merlin Airik, Tilman Jobst-Schwan, Svjetlana Lovric, Daniela A Braun, Heon Yung Gee, David Schapiro, Amar J Majmundar, Carolin E Sadowski, Werner L Pabst, Ankana Daga, Amelie T van der Ven, Johanna M Schmidt, Boon Chuan Low, Anjali Bansal Gupta, Brajendra K Tripathi, Jenny Wong, Kirk Campbell, Kay Metcalfe, Denny Schanze, Tetsuya Niihori, Hiroshi Kaito, Kandai Nozu, Hiroyasu Tsukaguchi, Ryojiro Tanaka, Kiyoshi Hamahira, Yasuko Kobayashi, Takumi Takizawa, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Naonori Kumagai, Kazumoto Iijima, Henry Fehrenbach, Jameela A Kari, Sherif El Desoky, Sawsan Jalalah, Radovan Bogdanovic, Nataša Stajić, Hildegard Zappel, Assel Rakhmetova, Sharon-Rose Wassmer, Therese Jungraithmayr, Juergen Strehlau, Aravind Selvin Kumar, Arvind Bagga, Neveen A Soliman, Shrikant M Mane, Lewis Kaufman, Douglas R Lowy, Mohamad A Jairajpuri, Richard P Lifton, York Pei, Martin Zenker, Shigeo Kure, Friedhelm Hildebrandt
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20, ITSN1, ITSN2) as causing NS in 17 families with partially treatment-sensitive NS (pTSNS). These proteins interact and we delineate their roles in Rho-like small GTPase (RLSG) activity, and demonstrate deficiency for mutants of pTSNS patients. We find that CDK20 regulates DLC1. Knockdown of MAGI2, DLC1, or CDK20 in cultured podocytes reduces migration rate...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29773492/what-is-the-hospital-volume-threshold-to-optimize-inpatient-complication-rate-after-partial-nephrectomy
#4
Sohrab Arora, Jacob Keeley, Daniel Pucheril, Mani Menon, Craig G Rogers
OBJECTIVE: To find a cutoff of hospital volume for elective partial nephrectomy (PN) for kidney cancer that can minimize the inpatient morbidity of this procedure. MATERIAL AND METHODS: Analyzing the National Inpatient sample, from 2008 to 2011, we selected 8,753 records of adult patients undergoing elective PN for nonmetastatic kidney cancer, representing an estimated 43,178 partial nephrectomies performed in the United States during this period. Of these, 2,187 (estimated 10,848) PNs were performed via the robotic approach...
May 14, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29772819/do-young-people-ever-sit-still-variations-in-accelerometer-counts-muscle-activity-and-heart-rate-across-various-sedentary-activities-in-youth
#5
Evi van Ekris, Mai J M Chinapaw, Joost Rotteveel, Teatske M Altenburg
Evidence of adverse health effects of TV viewing is stronger than for overall sedentary behaviour in youth. One explanation may be that TV viewing involves less body movement than other sedentary activities. Variations in body movement across sedentary activities are currently unknown, as are age differences in such variations. This study examined body movement differences across various sedentary activities in children and adolescents, assessed by hip-, thigh- and wrist-worn accelerometers, muscle activity and heart rate...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29772066/3d-specific-absorption-rate-estimation-from-high-intensity-focused-ultrasound-sonications-using-the-green-s-function-heat-kernel
#6
Nicholas J Freeman, Henrik Odéen, Dennis L Parker
PURPOSE: Evaluate a numerical inverse Green's function method of deriving specific absorption rates (SARs) from high intensity focused ultrasound (HIFU) sonications given tissue parameters (thermal conductivity, specific heat capacity, and mass density) and 3-D magnetic resonance imaging (MRI) temperature measurements. METHODS: SAR estimates were evaluated using simulations and MR temperature measurements from HIFU sonications. For simulations, a "true" SAR was calculated using the hybrid angular spectrum method for ultrasound simulations...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29771782/differential-patterns-of-risk-and-vulnerability-suggest-the-need-for-novel-prevention-strategies-for-black-bisexual-men-in-the-hptn-061-study
#7
Typhanye V Dyer, Maria R Khan, Rotrease Regan, Nina T Harawa, LaRon E Nelson, Leo Wilton, Lei Wang, Lili Peng, San San Ou, Steve Shoptaw
BACKGROUND: Black men who have sex with men (BMSM); some who also have sex with women (BMSMW), account for over 70% of new HIV infections in the US representing an elevated HIV risk in this group, also informing risks for HIV transmission to other BMSM and female sexual partners. SETTINGS: We examined trajectories of self-reported substance use, HIV-related sexual risk behaviors and psychosocial vulnerabilities among BMSMW versus BMSM over a one-year study period...
May 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29769818/carbohydrate-mouth-rinse-and-hydration-strategies-on-cycling-performance-in-30-km-time-trial-a-randomized-crossover-controlled-trial
#8
Amanda M J Ferreira, Luiz F Farias-Junior, Thaynan A A Mota, Hassan M Elsangedy, Aline Marcadenti, Telma M A M Lemos, Alexandre H Okano, Ana P T Fayh
The aim of this study was to investigate whether carbohydrate mouth rinse (CMR) improves physical performance of cyclists during a 30-km time trial test and its influence on water balance compared to other strategies of fluid intake. Eleven recreationally trained male cyclists completed a 30 km time trial cycle ergometer under three experimental interventions: (a) CMR, (b) drinking to replace all weight loss (DWL), and (c) drinking "ad libitum" (DAL). Time to complete the 30 km time trial, heart rate, average power, velocity, weight loss, urine color, urine density and pH were evaluated...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29769375/baseline-nawm-structural-integrity-and-cbf-predict-periventricular-wmh-expansion-over-time
#9
Nutta-On Promjunyakul, Hiroko H Dodge, David Lahna, Erin L Boespflug, Jeffrey A Kaye, William D Rooney, Lisa C Silbert
OBJECTIVE: We aimed to describe and compare baseline cerebral blood flow (CBF) and microstructural characteristics of normal-appearing white matter (NAWM) within the vulnerable periventricular white matter hyperintensity (PVWMH) penumbra region in predicting white matter hyperintensity (WMH) growth over time. METHODS: Fifty-two patients, aged 82.8 years, underwent serial brain MRI, including pulsed arterial spin labeling and diffusion tensor imaging (DTI). New WMH and persistent NAWM voxels in relation to WMH penumbra at follow-up were identified...
May 16, 2018: Neurology
https://www.readbyqxmd.com/read/29769279/microbial-interactions-in-the-cystic-fibrosis-airway
#10
Ann M Granchelli, Frederick R Adler, Ruth H Keogh, Christiana Kartsonaki, David R Cox, Theodore G Liou
Interactions in the airway ecology of cystic fibrosis may alter organism persistence and clinical outcomes. Better understanding of such interactions could guide clinical decisions. We fitted logistic regression models using generalized estimating equations to longitudinal two-year patient cohorts in the Cystic Fibrosis Foundation Patient Registry, 2003-2011 to study associations between airway organisms present in each calendar year and their presence in the subsequent year. Models were adjusted for clinical characteristics and multiple observations per patient and tested for sensitivity to cystic fibrosis-specific treatments...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29769120/a-controlled-before-after-study-to-evaluate-the-effect-of-a-clinician-led-policy-to-reduce-knee-arthroscopy-in-nsw
#11
H Y Chen, I A Harris, K Sutherland, J-F Levesque
BACKGROUND: Clinical evidence shows knee arthroscopy has little benefit for degenerative conditions and considerable variation in the incidence of knee arthroscopy in Australia has been identified. This study aimed to evaluate a clinician-led evidence-based policy which was implemented in one local health district in New South Wales (NSW) in 2012 to reduce the use of knee arthroscopy for patients aged 50 years or over. METHODS: Trends in rates and volume of knee arthroscopy for patients 50 years or over in NSW between 2004 and 2015 by district were examined...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29769035/does-life-story-work-improve-psychosocial-well-being-for-older-adults-in-the-community-a-quasi-experimental-study
#12
Claudia K Y Lai, Ayumi Igarashi, Clare T K Yu, Kenny C W Chin
BACKGROUND: Previous studies have demonstrated that life story work has positive effects when used on older adults. This study aimed to examine the effect of life story work on the general mental well-being, self-esteem, and life satisfaction of older adults by comparing two groups - one with and one without depressive symptoms. METHODS: A quasi-experimental design was adopted in this study. One hundred and twenty-three adults aged 60 or above were recruited from community centers through convenience sampling...
May 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29768511/12-year-trends-in-cardiovascular-risk-factors-2002-2005-through-2011-2014-in-patients-with-cardiovascular-diseases-tehran-lipid-and-glucose-study
#13
SeyedHossein Rabani, Mahsa Sardarinia, Samaneh Akbarpour, Fereidoun Azizi, Davood Khalili, Farzad Hadaegh
BACKGROUND: To examine the trend of cardiovascular diseases (CVD) risk factors among a Middle Eastern population with prevalent CVD during a median follow up of 12 years. METHODS: Patients with prevalent CVD (n = 282, men = 167), with a mean age of 60.76 years were evaluated in four study phases of the TLGS (Tehran lipid glucose study), 2002-2005, 2005-2008, 2008-2011, and 2011-2014. Trends of CVD risk factors were estimated using generalized estimation equation (GEE) models, by adjusting for gender, age and propensity scores...
2018: PloS One
https://www.readbyqxmd.com/read/29768309/the-impact-of-a-change-in-the-price-of-va-health-care-on-utilization-of-va-and-medicare-services
#14
Richard E Nelson, Bret Hicken, Megan Vanneman, Chuan-Fen Liu, Randall Rupper
INTRODUCTION: The passage of the Veterans Access, Choice, and Accountability Act of 2014 has expanded the non-Veteran Affairs (VA) care options for eligible US Veterans. In order for these new arrangements to provide the best care possible for Veterans, it is important to understand the relationship between VA and non-VA care options. The purpose of this study was to use another recent VA policy change, one that increased the reimbursement rate that eligible Veterans receive for travel for health care to VA, to understand the use of VA and Medicare services among Medicare-enrolled Veterans...
May 15, 2018: Medical Care
https://www.readbyqxmd.com/read/29766531/nonparametric-analysis-of-dependently-interval-censored-failure-time-data
#15
Yayuan Zhu, Jerald F Lawless, Cecilia A Cotton
Failure time studies based on observational cohorts often have to deal with irregular intermittent observation of individuals, which produces interval-censored failure times. When the observation times depend on factors related to a person's failure time, the failure times may be dependently interval censored. Inverse-intensity-of-visit weighting methods have been developed for irregularly observed longitudinal or repeated measures data and recently extended to parametric failure time analysis. This article develops nonparametric estimation of failure time distributions using weighted generalized estimating equations and monotone smoothing techniques...
May 15, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29765872/effect-of-caregiver-driven-robot-assisted-in-ward-training-in-subacute-stroke-patients-a-case-series
#16
Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, Sook Joung Lee, Jin Gee Park, Joo Won Park
Objective: To evaluate the effect of caregiver driven robot-assisted in-ward training in subacute stroke patients. Methods: A retrospective evaluation was performed for patients treated with caregiver driven robot-assisted in-ward training to retain gait function from June 2014 and December 2016. All patients received more than 2 weeks of caregiver driven robot-assisted in-ward training after undergoing conventional programs. The robot was used as a sitting device, a standing frame, or a high-walker depending on functional status of the patient...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29764967/high-disease-activity-is-associated-with-self-reported-depression-and-predicts-persistent-depression-in-early-rheumatoid-arthritis-results-from-the-ontario-best-practices-research-initiative
#17
Bindee Kuriya, Raman Joshi, Mohammad Movahedi, Emmanouil Rampakakis, John S Sampalis, Claire Bombardier
OBJECTIVE: We sought to determine if initial high disease activity or changes in disease activity contribute to persistent depression in early rheumatoid arthritis (ERA). We also determined if disease activity and depression is modified by sex. METHODS: Depression was ascertained by self-report among patients enrolled in the Ontario Best Practices Research Initiative. The association between baseline disease activity, measured by the Clinical Disease Activity Index (CDAI), and persistent depression was evaluated with multivariate regression models, and effect modification by sex was tested...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29762865/population-pharmacokinetics-of-vancomycin-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#18
Akira Okada, Misato Kariya, Kei Irie, Yutaka Okada, Nobuhiro Hiramoto, Hisako Hashimoto, Ryosuke Kajioka, Chika Maruyama, Hidefumi Kasai, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Keizo Fukushima, Nobuyuki Sugioka
Vancomycin is a commonly used antimicrobial agent for patients undergoing allogeneic hematopoietic stem-cell transplantation (allo-HSCT). Vancomycin has large inter- and intraindividual pharmacokinetic variability, which is mainly described by renal function; various studies have indicated that vancomycin pharmacokinetics are altered in special populations. However, little is known regarding vancomycin pharmacokinetics in patients undergoing allo-HSCT. Therefore, we aimed to develop a population pharmacokinetic (PopPK) model of vancomycin in patients undergoing allo-HSCT for effective and safe antimicrobial therapy and to develop a vancomycin dosing nomogram for a vancomycin optimal-dosing strategy...
May 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29762697/sarcopenia-is-a-novel-predictor-of-the-need-for-rescue-therapy-in-hospitalized-ulcerative-colitis-patients
#19
Kelly C Cushing, Hamed Kordbacheh, Michael S Gee, Avinash Kambadakone, Ashwin N Ananthakrishnan
Background: Acute severe ulcerative colitis (ASUC) affects one in four patients with UC. Clinical parameters perform modestly in predicting need for rescue therapy. Sarcopenia and visceral adiposity predict natural history in Crohn's disease, but the role of such metabolic factors on ASUC outcomes is unknown. Aim: To define the effect of sarcopenia and visceral adiposity on outcomes in ASUC. Methods: We studied patients hospitalized for ASUC who underwent an abdominal CT scan during the hospitalization...
May 12, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29762643/educational-mobility-across-generations-and-depressive-symptoms-over-10-years-among-us-latinos
#20
Julia B Ward, Whitney R Robinson, Brian W Pence, Joanna Maselko, Sandra S Albrecht, Mary N Haan, Allison E Aiello
Few studies have collected intergenerational data to assess the association between educational mobility across multiple generations and offspring depression. Using data from the Sacramento Area Latino Study on Aging (1998-2008), we assessed the influence of intergenerational education on depressive symptoms over 10 years among 1,786 Latino individuals (mean age = 70.6 years). Educational mobility was classified: stable-low (low parent/low offspring education), upwardly mobile (low parent/high offspring education), stable-high (high parent/high offspring education), or downwardly mobile (high parent/low offspring education)...
May 14, 2018: American Journal of Epidemiology
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