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https://www.readbyqxmd.com/read/29907953/effectiveness-of-a-scerts-model-based-intervention-for-children-with-autism-spectrum-disorder-asd-in-hong-kong-a-pilot-study
#1
Lu Yu, Xiaoqin Zhu
A SCERTS model-based intervention with different durations (5-month vs. 10-month) was provided to 122 children with autism spectrum disorder (ASD) (age = 53.43 ± 9.05 months) in Hong Kong. Before and after the intervention, the children were assessed with the Chinese Psychoeducational Profile-Third Edition (CPEP-3) and the Developmental Assessment Chart (DAC). Educators and parents expressed their views toward the intervention in focus groups. Results showed that participating children improved significantly in their social communication and emotional behavior after the intervention, as measured by DAC and CPEP-3...
June 15, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29906401/school-nurses-increasing-the-compliance-of-hygiene-routines-for-students-with-autism-spectrum-disorder
#2
Constance E McIntosh, Jessica Gundlach, Pamela Brelage, Storey Snyder
School nurses are essential healthcare providers to children with autism spectrum disorder (ASD). In providing this care, school nurses may need to accommodate the unique challenges that children with ASD may face, including but not limited to sensory sensitivities, communicative and social difficulties, difficulties remembering event sequencing and directions, and poor time management skills. The aim of this article is to provide school nurses and healthcare providers evidence-based interventions and strategies that they may use to increase the compliance of hygiene behaviors and routines for children with ASD...
June 1, 2018: NASN School Nurse
https://www.readbyqxmd.com/read/29905970/neurexin-superfamily-cell-membrane-receptor-contactin-associated-protein-like-4-cntnap4-is-involved-in-neural-egfl-like-1-nell-1-responsive-osteogenesis
#3
Chenshuang Li, Zhong Zheng, Pin Ha, Xiaoyan Chen, Wenlu Jiang, Shan Sun, Feng Chen, Greg Asatrian, Emily A Berthiaume, Jong Kil Kim, Eric C Chen, Shen Pang, Xinli Zhang, Kang Ting, Chia Soo
Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily of transmembrane molecules that have critical functions in neuronal cell communication. Cntnap4 knockout mice display decreased presynaptic gamma-aminobutyric acid (GABA) and increased dopamine release that is associated with severe, highly penetrant, repetitive, and perseverative movements commonly found in human autism spectrum disorder patients. However, no known function of Cntnap4 has been revealed besides the nervous system...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29904907/systematic-review-and-guide-to-management-of-core-and-psychiatric-symptoms-in-youth-with-autism
#4
REVIEW
S H Ameis, C Kassee, P Corbett-Dick, L Cole, S Dadhwal, M-C Lai, J Veenstra-VanderWeele, C U Correll
OBJECTIVE: Evidence-based guidance of clinical decision-making for the management of Autism Spectrum Disorder (ASD) is lacking, particularly for co-occurring psychiatric symptoms. This review evaluates treatment evidence for six common symptom targets in children/adolescents with ASD and provides a resource to facilitate application of the evidence to clinical practice. METHOD: A systematic search identified randomized controlled trials (RCTs) and high-quality systematic reviews published between 2007 and 2016, focused on: social interaction/communication impairment, stereotypic/repetitive behaviours, irritability/agitation, attention-deficit/hyperactivity disorder symptoms, mood or anxiety symptoms, and sleep difficulties...
June 14, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29904533/using-the-tools-of-informal-science-education-to-connect-science-and-the-public
#5
April Killikelly
Traditional modes of communication within the scientific community, including presentation of data at conferences and in peer-reviewed publications, use technical jargon that limits public engagement. While altering word choice is an important method for increasing public engagement, the data itself may not be enough. For example, communicating the lack of evidence that vaccines cause autism did not convince many reluctant parents to vaccinate their kids (Nyhan, Reifler, Richey, Freed, Pediatrics 133:e835-e842, 2014)...
2018: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/29902778/toxic-metal-loid-based-pollutants-and-their-possible-role-in-autism-spectrum-disorder
#6
REVIEW
Geir Bjørklund, Anatoly V Skalny, Md Mostafizur Rahman, Maryam Dadar, Heba A Yassa, Jan Aaseth, Salvatore Chirumbolo, Margarita G Skalnaya, Alexey A Tinkov
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, verbal and non-verbal communication, and stereotypic behaviors. Many studies support a significant relationship between many different environmental factors in ASD etiology. These factors include increased daily exposure to various toxic metal-based environmental pollutants, which represent a cause for concern in public health. This article reviews the most relevant toxic metals, commonly found, environmental pollutants, i...
June 11, 2018: Environmental Research
https://www.readbyqxmd.com/read/29899405/pharmacological-modulation-of-ampa-receptor-rescues-social-impairments-in-animal-models-of-autism
#7
Ji-Woon Kim, Kwanghoon Park, Ri Jin Kang, Edson Luck T Gonzales, Do Gyeong Kim, Hyun Ah Oh, Hana Seung, Mee Jung Ko, Kyoung Ja Kwon, Ki Chan Kim, Sung Hoon Lee, ChiHye Chung, Chan Young Shin
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, featuring social communication deficit and repetitive/restricted behaviors as common symptoms. Its prevalence has continuously increased, but, till now, there are no therapeutic approaches to relieve the core symptoms, particularly social deficit. In previous studies, abnormal function of the glutamatergic neural system has been proposed as a critical mediator and therapeutic target of ASD-associated symptoms. Here, we investigated the possible roles of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) in autism symptoms using two well-known autistic animal models, Cntnap2 knockout (KO) mice and in utero valproic acid-exposed ICR (VPA) mice...
May 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29898212/association-of-autistic-traits-with-depression-from-childhood-to-age-18-years
#8
Dheeraj Rai, Iryna Culpin, Hein Heuvelman, Cecilia M K Magnusson, Peter Carpenter, Hannah J Jones, Alan M Emond, Stanley Zammit, Jean Golding, Rebecca M Pearson
Importance: Population-based studies following trajectories of depression in autism spectrum disorders (ASD) from childhood into early adulthood are rare. The role of genetic confounding and of potential environmental intermediaries, such as bullying, in any associations is unclear. Objectives: To compare trajectories of depressive symptoms from ages 10 to 18 years for children with or without ASD and autistic traits, to assess associations between ASD and autistic traits and an International Statistical Classification of Diseases, 10th Revision (ICD-10) depression diagnosis at age 18 years, and to explore the importance of genetic confounding and bullying...
June 13, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29890179/clinical-use-of-semantic-space-models-in-psychiatry-and-neurology-a-systematic-review-and-meta-analysis
#9
REVIEW
J N de Boer, A E Voppel, M J H Begemann, H G Schnack, F Wijnen, I E C Sommer
Verbal communication disorders are a hallmark of many neurological and psychiatric illnesses. Recent developments in computational analysis provide objective characterizations of these language abnormalities. We conducted a meta-analysis assessing semantic space models as a diagnostic or prognostic tool in psychiatric or neurological disorders. Diagnostic test accuracy analyses revealed reasonable sensitivity and specificity and high overall efficacy in differentiating between patients and controls (n=1680: Hedges' g =...
June 8, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29885454/alterations-in-neuronal-cytoskeletal-and-astrocytic-proteins-content-in-the-brain-of-the-autistic-like-mouse-strain-c58-j
#10
Barón-Mendoza Isabel, García Octavio, Calvo-Ochoa Erika, Rebollar-García Jorge Omar, Garzón-Cortés Daniel, Haro-Valencia Reyes, González-Arenas Aliesha
Autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by deficient social interaction, impaired communication as well as repetitive behaviors. ASD subjects present connectivity and neuroplasticity disturbances associated with morphological alterations in axons, dendrites, and dendritic spines. Given that the neuronal cytoskeleton and astrocytes have an essential role in regulating several mechanisms of neural plasticity, the aim of this work was to study alterations in the content of neuronal cytoskeletal components actin and tubulin and their associated proteins, as well as astrocytic proteins GFAP and TSP-1 in the brain of a C58/J mouse model of ASD...
June 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29883735/transient-increased-thalamic-sensory-connectivity-and-decreased-whole-brain-dynamism-in-autism
#11
REVIEW
Zening Fu, Yiheng Tu, Xin Di, Yuhui Du, Jing Sui, Bharat B Biswal, Zhiguo Zhang, N de Lacy, V D Calhoun
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits and restricted/repetitive behaviors and is characterized by large-scale atypical subcortical-cortical connectivity, including impaired resting-state functional connectivity between thalamic and sensory regions. Previous studies have typically focused on the abnormal static connectivity in ASD and overlooked potential valuable dynamic patterns in brain connectivity. However, resting-state brain connectivity is indeed highly dynamic, and abnormalities in dynamic brain connectivity have been widely identified in psychiatric disorders...
June 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29879612/a-systematic-review-of-screening-tools-in-non-young-children-and-adults-for-autism-spectrum-disorder
#12
REVIEW
Tomoya Hirota, Ryuhei So, Young Shin Kim, Bennett Leventhal, Richard A Epstein
BACKGROUND: Existing reviews of screening tools for Autism Spectrum Disorder (ASD) focus on young children, and not all screening tools have been examined against validated diagnostic procedures. AIMS: To examine the validity of screening tools for ASD in non-young children and adults to provide clinical recommendations about the use of these tools in a variety of clinical settings. METHODS AND PROCEDURES: Electronic databases, including MEDLINE, EMBASE, PsychINFO, Cochrane Library and CINAHL, were searched through March 2017...
June 4, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29879582/genetic-testing-and-autism-tutorial-for-communication-sciences-and-disorders
#13
Laura S DeThorne, Stephanie Ceman
This tutorial provides professionals in communication sciences and disorders with an overview of the molecular basis and parental perceptions of genetic testing as associated with autism. The introduction notes the prominence of genetic testing within present-day medical practices and highlights related limitations and concerns through the lens of disability critique. The body of the tutorial provides an overview of four different forms of genetic variation, highlighting the potential associations with autism and available genetic testing...
May 28, 2018: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29876630/neuromotor-and-cognitive-responses-of-adults-with-autism-spectrum-disorder-compared-to-neurotypical-adults
#14
Steven Morrison, Cortney N Armitano, C Teal Raffaele, Stephen I Deutsch, Serina A Neumann, Hope Caracci, Maria R Urbano
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder, whose core symptom domains include impaired social communication and narrowed interests and/or repetitive behaviors; in addition, deficits of general cognition, neuromotor function, and movement ability can be observed. This study was designed to examine differences in neuromotor and cognitive functions for a group of young adults with ASD and age-matched controls. It was also of interest to assess whether changes in the intra-individual variability (IIV) of these selected neuromotor and cognitive tasks also occurred...
June 6, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29876255/brain-activity-for-spontaneous-and-explicit-mentalizing-in-adults-with-autism-spectrum-disorder-an-fmri-study
#15
Annabel D Nijhof, Lara Bardi, Marcel Brass, Jan R Wiersema
The socio-communicative difficulties of individuals with autism spectrum disorder (ASD) are hypothesized to be caused by a specific deficit in the ability to represent one's own and others' mental states, referred to as Theory of Mind or mentalizing. However, many individuals with ASD show successful performance on explicit measures of mentalizing, and for this reason, the deficit is thought to be better captured by measures of spontaneous mentalizing. While there is initial behavioral support for this hypothesis, spontaneous mentalizing in ASD has not yet been studied at the neural level...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29875881/mindfulness-based-program-for-children-with-autism-spectrum-disorder-and-their-parents-direct-and-long-term-improvements
#16
Anna Ridderinkhof, Esther I de Bruin, René Blom, Susan M Bögels
A combined mindfulness-based program for children and their parents (MYmind) was beneficial for adolescents with autism spectrum disorder (ASD). In this study, we investigated whether this program is also beneficial for younger children with ASD, whether effects last on the long-term, and whether it reduces common comorbid problems. Forty-five children referred with ASD aged 8 until 19 years old, and their parents participated. Repeated measures of children's and parents' social communication problems, emotional and behavioral functioning, mindful awareness, and of parenting were conducted pre-intervention, post intervention, 2-month follow-up, and 1-year follow-up...
2018: Mindfulness
https://www.readbyqxmd.com/read/29873016/commentary-measuring-language-change-through-natural-language-samples
#17
Mihaela Barokova, Helen Tager-Flusberg
The role of language in autism spectrum disorder (ASD), more specifically, its function in social communication and strong predictive power on future outcomes, warrants language assessments that have good psychometric properties that capture the heterogeneity of language ability found among diagnosed individuals. Given the rapid growth in intervention and treatment research, there is an urgent need for the development and implementation of outcome measures that are easily obtained and sensitive to change. In this commentary, we argue for the use of natural language samples as measures of expressive language and communication for this purpose and review the literature on their implementation in ASD research...
June 5, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29872390/resveratrol-prevents-cellular-and-behavioral-sensory-alterations-in-the-animal-model-of-autism-induced-by-valproic-acid
#18
Mellanie Fontes-Dutra, Júlio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Gustavo Della-Flora Nunes, Mauro Mozael Hirsch, Guilherme Bauer-Negrini, Rudimar S Riesgo, Victorio Bambini-Júnior, Cecília Hedin-Pereira, Carmem Gottfried
Autism spectrum disorder (ASD) is characterized by impairments in both social communication and interaction and repetitive or stereotyped behaviors. Although its etiology remains unknown, genetic and environmental risk factors have been associated with this disorder, including the exposure to valproic acid (VPA) during pregnancy. Resveratrol (RSV) is an anti-inflammatory and antioxidant molecule known to prevent social impairments in the VPA animal model of autism. This study aimed to analyze the effects of prenatal exposure to VPA, as well as possible preventive effects of RSV, on sensory behavior, the localization of GABAergic parvalbumin (PV+ ) neurons in sensory brain regions and the expression of proteins of excitatory and inhibitory synapses...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29870399/antioxidants-and-autism-teachers-perceptions-of-behavioral-changes
#19
Amy Sadek, Lee S Berk, Karen Mainess, Noha S Daher
BACKGROUND- Children with Autism Spectrum Disorder (ASD) demonstrate a physiological imbalance between free radicals, resultant from oxidative stress, and antioxidants. Oxidative stress is linked to the pathogenesis of this neurocognitive disorder. The aim of this pilot feasibility study was to examine the effect of consumption of high concentration antioxidant cacao on behavior of children with ASD. METHODS- This was a 4-week pre-test post-test experimental pilot study of high antioxidant cacao and children with ASD...
June 5, 2018: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29869894/health-information-sources-perceived-vaccination-benefits-and-maintenance-of-childhood-vaccination-schedules
#20
Juwon Hwang, Dhavan V Shah
Parental concerns over the safety or necessity of childhood vaccination have increased over the past decades. At the same time, there has been a proliferation of vaccine-related information available through a range of health information sources. This study investigates the associations between evaluations of health information sources, parental perceptions of childhood vaccination benefits, and the maintenance of vaccination schedules for their children. Specifically, this study aims to (a) incorporate social media into the battery of health information sources and (b) differentiate households with a childhood autism diagnosis and those without, given unsubstantiated but persistent concerns about vaccine safety and autism...
June 5, 2018: Health Communication
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