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https://www.readbyqxmd.com/read/28324772/new-proposals-of-the-who-working-group-2016-for-the-diagnosis-of-myelodysplastic-syndromes-mds-characteristics-of-refined-mds-types
#1
Corinna Strupp, Kathrin Nachtkamp, Barbara Hildebrandt, Aristoteles Giagounidis, Rainer Haas, Norbert Gattermann, John M Bennett, Carlo Aul, Ulrich Germing
Based on centrally diagnosed 3528 patients in the Düsseldorf registry, we validated the new proposals for the classification of the MDS by the WHO working group: 256 patients were diagnosed as MDSSLD (7,3%), 978 MDSMLD (27,7%), 227 MDS RS SLD (6,4%); 321 MDS RS MLD (9,1%), 159 MDS del(5q) (4,5%), 481 MDSEB 1 (13,6%), 620 MDSEB 2 (17,6%), and 148 MDS-U (4,2%). 352 patients (16,9% of the non blastic types) changed the category, mainly moving from RCMD to MDS RS MLD, RCUD and RCMD to MDS del(5q). Median survival times of the refined groups differed from more than 60 months in the MDSSLD (RS) groups, 37 months in the MDSMLD (RS) groups, 79 months of the MDS del(5q) group and 21 and 11 months in the MDSEB 1 and 2 groups, respectively...
February 27, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28320158/addressing-post-stroke-care-in-rural-areas-with-peru-as-a-case-study-placing-emphasis-on-evidence-based-pragmatism
#2
REVIEW
J Jaime Miranda, Miguel G Moscoso, Lijing L Yan, Francisco Diez-Canseco, Germán Málaga, Hector H Garcia, Bruce Ovbiagele
Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local healthcare workers and family caregivers in these regions lack the necessary knowledge to assist them. Intriguingly, a recent rapid growth in cell-phone use and digital technology in rural areas has not yet been appropriately exploited for health care training and delivery purposes. What should be done in rural areas, at the community setting-level, where access to healthcare is limited remains a challenge...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319832/comparative-life-cycle-cost-assessment-of-painted-and-hot-dip-galvanized-bridges
#3
B Rossi, S Marquart, G Rossi
The study addresses the life cycle cost assessment (LCCA) of steel bridges, focusing on the maintenance activities and the maintenance scenario. Firstly, the unit costs of maintenance activities and their durability (i.e. the time between two activities) are evaluated. Pragmatic data are provided for the environment category C4 and for three activities: Patch Up, Overcoating and Remove & Replace. A comparative LCCA for a typical hypothetic steel girder bridge is carried out, either painted or hot-dip galvanized (HDG), in the environmental class C4...
March 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28318699/significance-of-metabolites-in-the-environmental-risk-assessment-of-pharmaceuticals-consumed-by-human
#4
Eun Jeong Han, Dong Soo Lee
The purpose of this study is to demonstrate the significance of metabolites to the ERA of human pharmaceuticals. The predicted exposure concentrations (PECs) in surface water were estimated for a total of 24 selected active pharmaceutical ingredients (APIs) and their metabolites using a life cycle based emission estimation model combined with a multimedia fate model with Monte-Carlo calculations. With the eco-toxicity data, the hazard quotients (HQs) of the metabolites were compared with those of individual parents alone...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28317467/ethnographic-perspectives-on-global-mental-health
#5
Sumeet Jain, David M R Orr
The field of Global Mental Health (GMH) aims to influence mental health policy and practice worldwide, with a focus on human rights and access to care. There have been important achievements, but GMH has also been the focus of scholarly controversies arising from political, cultural, and pragmatic critiques. These debates have become increasingly polarized, giving rise to a need for more dialogue and experience-near research to inform theorizing. Ethnography has much to offer in this respect. This paper frames and introduces five articles in this issue of Transcultural Psychiatry that illustrate the role of ethnographic methods in understanding the effects and implications of the field of global mental health on mental health policy and practice...
December 2016: Transcultural Psychiatry
https://www.readbyqxmd.com/read/28317033/returning-genome-sequences-to-research-participants-policy-and-practice
#6
Caroline F Wright, Anna Middleton, Jeffrey C Barrett, Helen V Firth, David R FitzPatrick, Matthew E Hurles, Michael Parker
Despite advances in genomic science stimulating an explosion of literature around returning health-related findings, the possibility of returning entire genome sequences to individual research participants has not been widely considered. Through direct involvement in large-scale translational genomics studies, we have identified a number of logistical challenges that would need to be overcome prior to returning individual genome sequence data, including verifying that the data belong to the requestor and providing appropriate informatics support...
February 24, 2017: Wellcome Open Res
https://www.readbyqxmd.com/read/28316263/individualised-dietary-strategies-for-olympic-combat-sports-acute-weight-loss-recovery-and-competition-nutrition
#7
Reid Reale, Gary Slater, Louise M Burke
Olympic combat sports separate athletes into weight divisions, in an attempt to reduce size, strength, range and/or leverage disparities between competitors. Official weigh-ins are conducted anywhere from 3 and up to 24 h prior to competition ensuring athletes meet weight requirements (i.e. have 'made weight'). Fighters commonly aim to compete in weight divisions lower than their day-to-day weight, achieved via chronic and acute manipulations of body mass (BM). Although these manipulations may impair health and absolute performance, their strategic use can improve competitive success...
March 19, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28315812/onset-of-coagulation-function-recovery-is-delayed-in-severely-injured-trauma-patients-with-venous-thromboembolism
#8
Belinda H McCully, Christopher R Connelly, Kelly A Fair, John B Holcomb, Erin E Fox, Charles E Wade, Eileen M Bulger, Martin A Schreiber
BACKGROUND: Altered coagulation function after trauma may contribute to venous thromboembolism (VTE) development. Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely-injured trauma patients. STUDY DESIGN: Secondary analysis was performed on data from The Pragmatic Randomized Optimal Platelet and Plasma Ratio (PROPPR) trial, excluding patients who died within 24 hours and/or were on pre-injury anticoagulants...
March 15, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28314943/predicting-hospital-stay-mortality-and-readmission-in-people-admitted-for-hypoglycaemia-prognostic-models-derivation-and-validation
#9
Francesco Zaccardi, David R Webb, Melanie J Davies, Nafeesa N Dhalwani, Laura J Gray, Sudesna Chatterjee, Gemma Housley, Dominick Shaw, James W Hatton, Kamlesh Khunti
AIMS/HYPOTHESIS: Hospital admissions for hypoglycaemia represent a significant burden on individuals with diabetes and have a substantial economic impact on healthcare systems. To date, no prognostic models have been developed to predict outcomes following admission for hypoglycaemia. We aimed to develop and validate prediction models to estimate risk of inpatient death, 24 h discharge and one month readmission in people admitted to hospital for hypoglycaemia. METHODS: We used the Hospital Episode Statistics database, which includes data on all hospital admission to National Health Service hospital trusts in England, to extract admissions for hypoglycaemia between 2010 and 2014...
March 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28314666/microbial-oil-a-plausible-alternate-resource-for-food-and-fuel-application
#10
REVIEW
B Bharathiraja, Sridevi Sridharan, V Sowmya, D Yuvaraj, R Praveenkumar
Microbes have recourse to low-priced substrates like agricultural wastes and industrial efflux. A pragmatic approach towards an emerging field- the exploitation of microbial oils for biodiesel production, pharmaceutical and cosmetic applications, food additives, biopolymer production will be of immense remunerative significance in the near future. Due to high free fatty acid, nutritive content and simpler solvent extraction processes of microbial oils with plant oil, microbial oils can back plant oils in food applications...
March 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28302888/investigation-of-productivity-in-a-south-indian-malabari-goat-herd-shows-opportunities-for-planned-animal-health-management-to-improve-food-security
#11
N D Sargison, S A J Ivil, J Abraham, S P S Abubaker, A M Hopker, S Mazeri, I A Otter, N Otter
Here the authors report the objective veterinary clinical measurement of productivity in a representative south Indian Malabari goat herd. The authors show failure to meet pragmatic production targets that are commensurate with the animals' genetic potential or adequate to meet the demands of global food security. The authors suggest that this situation may have arisen as a consequence of animal husbandry constraints and protein undernutrition and imply the involvement of nematode parasitism. Benzimidazole resistance was detected in Haemonchus species, showing the need for better understanding of the principles of sustainable helminth parasite control within the southern Indian context...
March 18, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28302703/predictors-and-moderators-of-treatment-outcome-in-patients-receiving-multi-element-psychosocial-intervention-for-early-psychosis-results-from-the-get-up-pragmatic-cluster-randomised-controlled-trial
#12
Antonio Lasalvia, Chiara Bonetto, Jacopo Lenzi, Paola Rucci, Laura Iozzino, Massimo Cellini, Carla Comacchio, Doriana Cristofalo, Armando D'Agostino, Giovanni de Girolamo, Katia De Santi, Daniela Ghigi, Emanuela Leuci, Maurizio Miceli, Anna Meneghelli, Francesca Pileggi, Silvio Scarone, Paolo Santonastaso, Stefano Torresani, Sarah Tosato, Angela Veronese, Angelo Fioritti, Mirella Ruggeri
BackgroundThe GET UP multi-element psychosocial intervention proved to be superior to treatment as usual in improving outcomes in patients with first-episode psychosis (FEP). However, to guide treatment decisions, information on which patients may benefit more from the intervention is warranted.AimsTo identify patients' characteristics associated with (a) a better treatment response regardless of treatment type (non-specific predictors), and (b) a better response to the specific treatment provided (moderators)...
March 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28302281/the-art-and-science-of-pediatric-damage-control
#13
Anthony Tran, Brendan T Campbell
Damage control is a surgical strategy that has evolved and expanded considerably over the past 25 years. The approach was initially developed as a "bail out" procedure to control bleeding with severe abdominal injuries in the setting of unmitigated hemorrhagic shock. Damage control is now more broadly applied as a comprehensive management plan for the resuscitation and surgical treatment of injured patients with exhausted physiologic and metabolic reserve. This article reviews the most current concepts in damage control that are important and relevant to the practicing pediatric surgeon...
February 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28302179/balanced-crystalloids-versus-saline-in-the-intensive-care-unit-study-protocol-for-a-cluster-randomized-multiple-crossover-trial
#14
Matthew W Semler, Wesley H Self, Li Wang, Daniel W Byrne, Jonathan P Wanderer, Jesse M Ehrenfeld, Joanna L Stollings, Avinash B Kumar, Antonio Hernandez, Oscar D Guillamondegui, Addison K May, Edward D Siew, Andrew D Shaw, Gordon R Bernard, Todd W Rice
BACKGROUND: Saline, the intravenous fluid most commonly administered to critically ill adults, contains a high chloride content, which may be associated with acute kidney injury and death. Whether using balanced crystalloids rather than saline decreases the risk of acute kidney injury and death among critically ill adults remains unknown. METHODS: The Isotonic Solutions and Major Adverse Renal Events Trial (SMART) is a pragmatic, cluster-level allocation, cluster-level crossover trial being conducted between 1 June 2015 and 30 April 2017 in five intensive care units at Vanderbilt University Medical Center in Nashville, TN, USA...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28301845/dietary-intakes-of-arachidonic-acid-and-docosahexaenoic-acid-in-early-life-with-a-special-focus-on-complementary-feeding-in-developing-countries
#15
Stewart Forsyth, Sheila Gautier, Norman Salem
BACKGROUND: In developing countries, dietary intakes of arachidonic acid (ARA) and docosahexaenoic acid (DHA) in early life are lower than current recommended levels. This review specifically focusses on the contribution that complementary feeding makes to ARA and DHA intakes in medium- to low-income countries. The aims of the review are (1) to determine the availability of ARA and DHA food sources in developing countries, (2) to estimate the contribution of complementary feeding to dietary intakes of ARA and DHA in infants aged 6-36 months, and (3) to relate the dietary ARA and DHA intake data to key socioeconomic and health indicators...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28298965/radiology-education-in-europe-analysis-of-results-from-22-european-countries
#16
Bhavya Rehani, Yi C Zhang, Madan M Rehani, András Palkó, Lawrence Lau, Miriam N Mikhail Lette, William P Dillon
AIM: To assess the state of radiology education across Europe by means of a survey study. METHODS: A comprehensive 23-item radiology survey was distributed via email to the International Society of Radiology members, national radiological societies, radiologists and medical physicists. Reminders to complete the survey were sent and the results were analyzed over a period of 4 mo (January-April 2016). Survey questions include length of medical school and residency training; availability of fellowship and subspecialty training; number of residency programs in each country; accreditation pathways; research training; and medical physics education...
February 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28297631/an-examination-of-suicide-research-and-funding-in-new-zealand-2006-16-implications-for-new-research-and-policies
#17
Daniel D L Coppersmith, Shyamala Nada-Raja, Annette L Beautrais
Objective Suicide is a significant public health problem in New Zealand, with the youth suicide rate being one of the highest among developed countries. Increased suicide rates in recent years suggest that the evidence base and research priorities for New Zealand suicide prevention need to be reassessed. To inform policy development, the aim of the present study was to evaluate all peer-reviewed New Zealand published suicide research and major grant allocations from 2006 to 2016.Methods The methodology duplicated a recent Australian review of suicide prevention research and funding...
March 16, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28296973/quantitative-analysis-of-disfluency-in-children-with-autism-spectrum-disorder-or-language-impairment
#18
Heather MacFarlane, Kyle Gorman, Rosemary Ingham, Alison Presmanes Hill, Katina Papadakis, Géza Kiss, Jan van Santen
Deficits in social communication, particularly pragmatic language, are characteristic of individuals with autism spectrum disorder (ASD). Speech disfluencies may serve pragmatic functions such as cueing speaking problems. Previous studies have found that speakers with ASD differ from typically developing (TD) speakers in the types and patterns of disfluencies they produce, but fail to provide sufficiently detailed characterizations of the methods used to categorize and quantify disfluency, making cross-study comparison difficult...
2017: PloS One
https://www.readbyqxmd.com/read/28296527/pragmatics-of-language-and-theory-of-mind-in-children-with-dyslexia-with-associated-language-difficulties-or-nonverbal-learning-disabilities
#19
Ramona Cardillo, Ricardo Basso Garcia, Irene C Mammarella, Cesare Cornoldi
The present study aims to find empirical evidence of deficits in linguistic pragmatic skills and theory of mind (ToM) in children with dyslexia with associated language difficulties or nonverbal learning disabilities (NLD), when compared with a group of typically developing (TD) children matched for age and gender. Our results indicate that children with dyslexia perform less well than TD children in most of the tasks measuring pragmatics of language, and in one of the tasks measuring ToM. In contrast, children with NLD generally performed better than the dyslexia group, and performed significantly worse than the TD children only in a metaphors task based on visual stimuli...
March 15, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28295141/adherence-and-tolerability-of-alzheimer-s-disease-medications-a-pragmatic-randomized-trial
#20
Noll L Campbell, Anthony J Perkins, Sujuan Gao, Todd C Skaar, Lang Li, Hugh C Hendrie, Nicole Fowler, Christopher M Callahan, Malaz A Boustani
BACKGROUND/OBJECTIVES: Post-marketing comparative trials describe medication use patterns in diverse, real-world populations. Our objective was to determine if differences in rates of adherence and tolerability exist among new users to acetylcholinesterase inhibitors (AChEI's). DESIGN: Pragmatic randomized, open label comparative trial of AChEI's currently available in the United States. SETTING: Four memory care practices within four healthcare systems in the greater Indianapolis area...
March 14, 2017: Journal of the American Geriatrics Society
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