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Pragmatics

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https://www.readbyqxmd.com/read/27910210/microbiological-evaluation-of-the-extension-wire-and-percutaneous-epidural-lead-anchor-site-following-a-2-stage-cut-down-spinal-cord-stimulator-procedure
#1
Abdul Ghaaliq Lalkhen, Mahindra Chincholkar, Jiten Patel
OBJECTIVES: There are concerns regarding bacterial colonization of the temporary extension leads and subsequent infection risk using the 2-stage cut-down approach in spinal cord stimulation (SCS). We sought to quantify the extent of bacterial colonization of the temporary extension wire and percutaneous epidural lead anchor site. MATERIALS AND METHODS: We conducted a cross-sectional observational study recruiting a pragmatic sample of 25 consecutive patients listed for a cut-down trial of SCS...
December 2, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27907080/development-of-an-automated-mri-based-diagnostic-protocol-for-amyotrophic-lateral-sclerosis-using-disease-specific-pathognomonic-features-a-quantitative-disease-state-classification-study
#2
Christina Schuster, Orla Hardiman, Peter Bede
BACKGROUND: Despite significant advances in quantitative neuroimaging, the diagnosis of ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis. The objective of this study is to develop a robust, disease-specific, multimodal classification protocol and validate its diagnostic accuracy in independent, early-stage and follow-up data sets. METHODS: 147 participants (81 ALS patients and 66 healthy controls) were divided into a training sample and a validation sample...
2016: PloS One
https://www.readbyqxmd.com/read/27906464/methodological-considerations-for-optimizing-and-validating-behavioral-assays
#3
Stacey J Sukoff Rizzo, Jill L Silverman
Preclinical animal models are indispensable tools for translational research for which behavioral characterization and phenotyping are essential to testing hypotheses and for evaluating the potential of novel therapeutic agents to treat diseases. The methods employed for comprehensive behavioral phenotyping and pharmacological experiments are complex and should be conducted exclusively by trained technicians with demonstrated proficiency. The ultimate goal is to identify disease-relevant and translational behavioral endpoints that are robust, reliable, and reproducible, and that can be employed to evaluate potential of novel therapeutic agents to treat disease...
December 1, 2016: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/27903559/randomised-controlled-trial-of-alternative-messages-to-increase-enrolment-in-a-healthy-food-programme-among-individuals-with-diabetes
#4
A Gopalan, J Paramanund, P A Shaw, D Patel, J Friedman, C Brophy, A M Buttenheim, A B Troxel, D A Asch, K G Volpp
OBJECTIVES: We compared the effectiveness of diabetes-focused messaging strategies at increasing enrolment in a healthy food programme among adults with diabetes. METHODS: Vitality is a multifaceted wellness benefit available to members of Discovery Health, a South Africa-based health insurer. One of the largest Vitality programmes is HealthyFood (HF), an incentive-based programme designed to encourage healthier diets by providing up to 25% cashback on healthy food purchases...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27900185/benefits-of-a-novel-concept-of-home-based-exercise-with-the-aim-of-preventing-aspiration-pneumonia-and-falls-in-frail-older-women-a-pragmatic-controlled-trial
#5
Katsuhiko Takatori, Daisuke Matsumoto, Munenori Nishida, Shinnichiro Matsushita, Tatsuya Noda, Tomoaki Imamura
AIM: To investigate whether home-based exercise with the aim of preventing aspiration pneumonia and accidental falls improves swallowing-related and physical functions in community-dwelling frail older women. METHODS: Participants were 266 community-dwelling frail older women in a long-term care prevention class (mean (SD): age 75 (5) years). Participants were allocated to either an intervention group or a control group. In the intervention group, participants were asked to perform, at least three times a week for 6 months, a home-based exercise programme that was specifically developed to prevent aspiration pneumonia and accidental falls...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899215/toxicology-in-international-drug-control-prioritizing-the-most-harmful-persistent-and-prevalent-substances
#6
Susan C Ifeagwu, Martin Raithelhuber, Conor Crean, Dimitri Gerostamoulos, Heesun Chung, Justice N Tettey
The nature of the global drugs market has evolved rapidly and has become more complex with the emergence of new psychoactive substances (NPS), some of which have been associated with increased abuse, hospital emergency admissions and sometimes fatalities. NPS are characterized by geographic heterogeneity, with some only transient in nature and others not satisfying the criteria for harm required for international control. Consequently, a pragmatic response of the international community is to prioritize the most harmful, persistent and prevalent substances for action - an objective, which is hampered by the paucity of data on harms...
November 20, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27898253/establishing-equipoise-national-survey-of-the-treatment-of-pediatric-para-pneumonic-effusion-and-empyema
#7
Morgan K Richards, Jarod P Mcateer, Todd C Edwards, Lucas R Hoffman, Matthew P Kronman, Dennis W Shaw, Adam B Goldin
BACKGROUND: Despite six randomized trials of various treatments for pediatric para-pneumonic effusion (PPE), management approaches differ. The purpose of this study was to gain insight into opinions on PPE treatment with the goal of designing a definitive trial to generate consensus intervention guidelines. METHODS: To evaluate physician opinions regarding PPE management, we developed a survey based on input from a nationwide, multi-disciplinary advisory group that established content validity...
November 29, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27897180/quantifying-electronic-band-interactions-in-van-der-waals-materials-using-angle-resolved-reflected-electron-spectroscopy
#8
Johannes Jobst, Alexander J H van der Torren, Eugene E Krasovskii, Jesse Balgley, Cory R Dean, Rudolf M Tromp, Sense Jan van der Molen
High electron mobility is one of graphene's key properties, exploited for applications and fundamental research alike. Highest mobility values are found in heterostructures of graphene and hexagonal boron nitride, which consequently are widely used. However, surprisingly little is known about the interaction between the electronic states of these layered systems. Rather pragmatically, it is assumed that these do not couple significantly. Here we study the unoccupied band structure of graphite, boron nitride and their heterostructures using angle-resolved reflected-electron spectroscopy...
November 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/27896522/tapering-biologics-in-rheumatoid-arthritis-a-pragmatic-approach-for-clinical-practice
#9
Aleksander Lenert, Petar Lenert
Optimal rheumatoid arthritis (RA) therapy in daily clinical practice is based on the treat-to-target strategy. Quicker escalation of therapy and earlier introduction of biological disease-modifying anti-rheumatic drugs have led to improved outcomes in RA. However, chronic immunosuppressive therapy is associated with adverse events and higher costs. In addition, our patients frequently express a desire for lower dosing and drug holidays. Current clinical practice guidelines from the American College of Rheumatology and European League Against Rheumatism suggest that rheumatologists consider tapering treatment after achieving remission...
November 28, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27895583/matching-adherence-interventions-to-patient-determinants-using-the-theoretical-domains-framework
#10
REVIEW
Samuel S Allemann, Robby Nieuwlaat, Bart J F van den Bemt, Kurt E Hersberger, Isabelle Arnet
Introduction: Despite much research, interventions to improve medication adherence report disappointing and inconsistent results. Tailored approaches that match interventions and patient determinants of non-adherence were seldom used in clinical trials. The presence of a multitude of theoretical frameworks and models to categorize interventions and patient determinants complicated the development of common categories shared by interventions and determinants. We retrieved potential interventions and patient determinants from published literature on medication adherence, matched them like locks and keys, and categorized them according to the Theoretical Domains Framework (TDF)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27894950/untying-the-gordian-knot-of-pericardial-diseases-a-pragmatic-approach
#11
REVIEW
George Lazaros, Massimo Imazio, Antonio Brucato, Dimitrios Tousoulis
Pericardial disorders constitute a relatively common cause of heart disease. Although acute pericarditis, and especially the idiopathic forms which are the most prevalent, is considered a benign disease overall, it's short and long term complications, namely recurrent pericarditis, cardiac tamponade and constrictive pericarditis constitute a matter of concern in the medical community. In recent years several clinical trials contributed to redefine our traditional approach to pericardial diseases. In this review we provide the most recent evidence concerning diagnosis, treatment modalities and short and long-term prognosis of the most common pericardial disorders...
November 25, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27894822/a-parallel-group-randomised-open-blinded-evaluation-of-acceptance-and-commitment-therapy-for-depression-after-psychosis-pilot-trial-outcomes-adapt
#12
Andrew Gumley, Ross White, Andy Briggs, Ian Ford, Sarah Barry, Corinna Stewart, Sara Beedie, Jacqueline McTaggart, Caoimhe Clarke, Rachel MacLeod, Emma Lidstone, Bruno Salgado Riveros, Robin Young, Hamish McLeod
BACKGROUND: Depression is one of the major contributors to poorer quality of life amongst individuals with psychosis and schizophrenia. The study was designed as a Pilot Trial to determine the parameters of a larger, definitive pragmatic multi-centre randomised controlled trial of Acceptance and Commitment Therapy for depression after psychosis (ACTdp) for individuals with a diagnosis of schizophrenia who also meet diagnostic criteria for major depression. METHODS: Participants were required to meet criteria for schizophrenia and major depression...
November 25, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27894295/impact-of-a-web-based-tool-webconsort-to-improve-the-reporting-of-randomised-trials-results-of-a-randomised-controlled-trial
#13
Sally Hopewell, Isabelle Boutron, Douglas G Altman, Ginny Barbour, David Moher, Victor Montori, David Schriger, Jonathan Cook, Stephen Gerry, Omar Omar, Peter Dutton, Corran Roberts, Eleni Frangou, Lei Clifton, Virginia Chiocchia, Ines Rombach, Karolina Wartolowska, Philippe Ravaud
BACKGROUND: The CONSORT Statement is an evidence-informed guideline for reporting randomised controlled trials. A number of extensions have been developed that specify additional information to report for more complex trials. The aim of this study was to evaluate the impact of using a simple web-based tool (WebCONSORT, which incorporates a number of different CONSORT extensions) on the completeness of reporting of randomised trials published in biomedical publications. METHODS: We conducted a parallel group randomised trial...
November 28, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27893232/narrative-production-in-children-with-autism-spectrum-disorder-asd-and-children-with-attention-deficit-hyperactivity-disorder-adhd-similarities-and-differences
#14
Sanne J M Kuijper, Catharina A Hartman, Suzanne T M Bogaerds-Hazenberg, Petra Hendriks
The present study focuses on the similarities and differences in language production between children with autism spectrum disorder (ASD) and children with attention-deficit/hyperactivity disorder (ADHD). In addition, we investigated whether Theory of Mind (ToM), working memory, and response inhibition are associated with language production. Narratives, produced by 106 Dutch-speaking children (36 with ASD, 34 with ADHD, and 36 typically developing) aged 6 to 12 during ADOS assessment, were examined on several linguistic measures: verbal productivity, speech fluency, syntactic complexity, lexical semantics, and discourse pragmatics...
November 28, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27891570/pragmatic-approach-to-manage-new-oral-anticoagulants-in-patients-undergoing-dental-extractions-a-prospective-case-control-study
#15
Isabel Miclotte, Maarten Vanhaverbeke, Jimoh Olubanwo Agbaje, Paul Legrand, Thomas Vanassche, Peter Verhamme, Constantinus Politis
OBJECTIVES: The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. MATERIALS AND METHODS: This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure...
November 28, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27891165/postprandial-lipemic-and-inflammatory-responses-to-high-fat-meals-a-review-of-the-roles-of-acute-and-chronic-exercise
#16
REVIEW
Colby S Teeman, Stephanie P Kurti, Brooke J Cull, Sam R Emerson, Mark D Haub, Sara K Rosenkranz
Postprandial lipemia is an independent risk factor for development of cardiovascular disease. Postprandial inflammation following the prolonged elevation of triglycerides occurring subsequent to ingestion of high-fat meals, provides a likely explanation for increased disease risk. Substantial evidence has shown that acute exercise is an effective modality for attenuation of postprandial lipemia following a high-fat meal. However, much of the evidence pertaining to exercise intensity, duration, and overall energy expenditure for reducing postprandial lipemia is inconsistent...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27889785/overcoming-cost-implications-of-mutational-analysis-in-patients-with-gastrointestinal-stromal-tumors-a-pragmatic-approach
#17
Patrick Schöffski, Agnieszka Wozniak, Oliver Schöffski, Liesbet van Eycken, Maria Debiec-Rychter
BACKGROUND: Genetic analysis of tissue derived from patients with advanced gastrointestinal stromal tumors (GISTs) is not uniformly applied on a national and international level, even though mutational data can provide clinically relevant prognostic and predictive information, especially in patients qualifying for treatment with expensive targeted agents. METHODS: The current article describes the rationale for genetic testing of GIST tissue, looks at financial implications associated with such analysis and speculates on potential cost savings introduced by routine mutational testing and tailored use of tyrosine kinase inhibitors based on genotyping...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27889288/quiet-dissent-the-attitudes-beliefs-and-behaviours-of-uk-osteopaths-who-reject-low-back-pain-guidance-a-qualitative-study
#18
Joanna Figg-Latham, Dévan Rajendran
INTRODUCTION: Clinical guidelines are derived from best research evidence and aim to: improve quality of non-specific low back pain (nsLBP) management and identify patients at risk of suffering chronic pain. However, guideline discordant attitudes and beliefs have been identified in healthcare students and practitioners, including osteopaths. DESIGN: A qualitative approach with elements of grounded theory was used to explore underlying attitudes and beliefs of practitioners/students working in a British osteopathic education institution...
October 18, 2016: Manual Therapy
https://www.readbyqxmd.com/read/27888367/increasing-opportunities-for-question-asking-in-school-aged-children-with-autism-spectrum-disorder-effectiveness-of-staff-training-in-pivotal-response-treatment
#19
Rianne Verschuur, Bibi Huskens, Ludo Verhoeven, Robert Didden
Deficits in question-asking are common in children with autism spectrum disorder (ASD). Furthermore, their opportunities to self-initiate questions are often hindered by directive behavior of their conversation partners. This study assessed the effectiveness of staff training in pivotal response treatment (PRT) on staff member-created opportunities and self-initiated questions of school-aged children with ASD. Generalization and maintenance were also assessed. Participants were 14 staff members and children with ASD attending an inpatient treatment facility...
November 25, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27888180/northern-manhattan-hispanic-caregiver-intervention-effectiveness-study-protocol-of-a-pragmatic-randomised-trial-comparing-the-effectiveness-of-two-established-interventions-for-informal-caregivers-of-persons-with-dementia
#20
José A Luchsinger, Louis Burgio, Mary Mittelman, Ilana Dunner, Jed A Levine, Jian Kong, Stephanie Silver, Mildred Ramirez, Jeanne A Teresi
INTRODUCTION: The prevalence of dementia is increasing without a known cure, resulting in an increasing number of informal caregivers. Caring for a person with dementia results in increased stress and depressive symptoms. There are several behavioural interventions designed to alleviate stress and depressive symptoms in caregivers of persons with dementia with evidence of efficacy. Two of the best-known interventions are the New York University Caregiver Intervention (NYUCI) and the Resources for Enhancing Alzheimer's Caregivers Health (REACH)...
November 25, 2016: BMJ Open
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