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https://www.readbyqxmd.com/read/28188697/a-case-study-evaluating-deep-inspiration-breath-hold-and-intensity-modulated-radiotherapy-to-minimise-long-term-toxicity-in-a-young-patient-with-bulky-mediastinal-hodgkin-lymphoma
#1
Jonathan M Tomaszewski, Sarah Crook, Kenneth Wan, Lucille Scott, Farshad Foroudi
Radiotherapy plays an important role in the treatment of early-stage Hodgkin lymphoma, but late toxicities such as cardiovascular disease and second malignancy are a major concern. Our aim was to evaluate the potential of deep inspiration breath-hold (DIBH) and intensity-modulated radiotherapy (IMRT) to reduce cardiac dose from mediastinal radiotherapy. A 24 year-old male with early-stage bulky mediastinal Hodgkin lymphoma received involved-site radiotherapy as part of a combined modality programme. Simulation was performed in free breathing (FB) and DIBH...
February 11, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28144114/on-line-estimations-of-delivered-radiation-doses-in-three-dimensional-conformal-radiotherapy-treatments-of-carcinoma-uterine-cervix-patients-in-linear-accelerator
#2
Suman Kumar Putha, P U Saxena, S Banerjee, Challapalli Srinivas, B M Vadhiraja, Ramamoorthy Ravichandran, Mary Joan, K Dinesh Pai
Transmission of radiation fluence through patient's body has a correlation to the planned target dose. A method to estimate the delivered dose to target volumes was standardized using a beam level 0.6 cc ionization chamber (IC) positioned at electronic portal imaging device (EPID) plane from the measured transit signal (St) in patients with cancer of uterine cervix treated with three-dimensional conformal radiotherapy (3DCRT). The IC with buildup cap was mounted on linear accelerator EPID frame with fixed source to chamber distance of 146...
October 2016: Journal of Medical Physics
https://www.readbyqxmd.com/read/28129649/rectal-urinary-toxicity-after-hypofractionated-vs-conventional-radiotherapy-in-low-intermediate-risk-localized-prostate-cancer-systematic-review-and-meta-analysis
#3
Rossella Di Franco, Valentina Borzillo, Vincenzo Ravo, Gianluca Ametrano, Sara Falivene, Fabrizio Cammarota, Sabrina Rossetti, Francesco Jacopo Romano, Carmine D'Aniello, Carla Cavaliere, Gelsomina Iovane, Raffaele Piscitelli, Massimiliano Berretta, Paolo Muto, Gaetano Facchini
PURPOSE: The aim of this review was to compare radiation toxicity in Localized Prostate Cancer (LPC) patients who underwent conventional fractionation (CV), hypofractionated (HYPO) or extreme hypofractionated (eHYPO) radiotherapy. We analyzed the impact of technological innovation on the management of prostate cancer, attempting to make a meta-analysis of randomized trials. METHODS: PubMed database has been explored for studies concerning acute and late urinary/gastrointestinal toxicity in low/intermediate risk LPC patients after receiving radiotherapy...
22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28048561/su-f-t-452-influence-of-dose-calculation-algorithm-and-heterogeneity-correction-on-risk-categorization-of-patients-with-cardiac-implanted-electronic-devices-undergoing-radiotherapy
#4
P Iwai, L Nadler Lins
PURPOSE: There is a lack of studies with significant cohort data about patients using pacemaker (PM), implanted cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT) device undergoing radiotherapy. There is no literature comparing the cumulative doses delivered to those cardiac implanted electronic devices (CIED) calculated by different algorithms neither studies comparing doses with heterogeneity correction or not. The aim of this study was to evaluate the influence of the algorithms Pencil Beam Convolution (PBC), Analytical Anisotropic Algorithm (AAA) and Acuros XB (AXB) as well as heterogeneity correction on risk categorization of patients...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048510/su-f-t-499-anatomic-features-for-selection-of-electronic-tissue-compensation-radiotherapy-in-early-stage-breast-cancer-patients-after-breast-conserving-surgery
#5
Y Song, M Zhang, N Yue, L Gan, X Chen, T Zhang, G Ren
PURPOSE: To explore the correlations between anatomic features and dose-volumetric parameters in 3DCRT and eComp whole breast irradiation and identify the feasibility of anatomic parameters to predict the planning method selection. METHODS: We compared the effectiveness between conventional three-dimensional conformal radiotherapy (3DCRT) and electronic tissue compensation (eComp) for whole breast irradiation. 3DCRT and eComp planning techniques were used to generate treatment plans for 60 whole breast patients, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048298/su-f-j-99-dose-accumulation-and-evaluation-in-lung-sbrt-among-all-phases-of-respiration
#6
J D Azcona, J Burguete, B Barbes, J Aristu, M Moreno, A Zubiria, P Arce, J I Lagares
PURPOSE: To calculate the total planning dose on lung tumors (GTV) by accumulating the dose received in all respiration phases. METHODS: A patient 4D planning CT (phase-binned, from a Siemens Somatom CT) was used to locate the GTV of a lung tumor in all respiratory phases with Pinnacle (v9.10). GTV contours defined in all phases were projected to the reference phase, where the ITV was defined. Centroids were calculated for all the GTV projections. No deformation or rotation was taken into account...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048260/su-f-p-37-implementation-of-an-end-to-end-qa-test-of-the-radiation-therapy-imaging-planning-and-delivery-process-to-identify-and-correct-possible-sources-of-deviation
#7
F Salinas Aranda, V Suarez, S Arbiser, R Sansogne
PURPOSE: To implement an end-to-end QA test of the radiation therapy imaging, planning and delivery process, aimed to assess the dosimetric agreement accuracy between planned and delivered treatment, in order to identify and correct possible sources of deviation. To establish an internal standard for machine commissioning acceptance. METHODS: A test involving all steps of the radiation therapy: imaging, planning and delivery process was designed. The test includes analysis of point dose and planar dose distributions agreement between TPS calculated and measured dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048201/su-f-t-646-sbrt-lung-moving-beyond-the-3d-conformal-paradigm-with-an-elekta-versahd-accelerator
#8
A Dalhart, D Hyer, B Allen, R Flynn, H Johnston
PURPOSE: To develop a volumetric modulated arc therapy (VMAT) planning and delivery methodology for lung stereotactic body radiation therapy (SBRT) that addresses the unique geometric challenges presented when using an Elekta VersaHD linear accelerator. METHODS: The Elekta VersaHD imaging panels are fixed at 160cm SID when deployed, limiting the ability to perform non-coplanar treatments due to collisions with the treatment table. The panels can be folded in a stored position for non-coplanar treatments, but in this configuration, longitudinal table travel is restricted by the space required for the folded panels...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047933/su-f-t-401-three-dimensional-conformal-planning-using-low-segment-multi-criteria-optimization-for-hippocampal-avoidance-whole-brain-radiotherapy
#9
X Zhang, J Penagaricano, G Narayanasamy, R Griffin, S Maraboyina, N Paudel, C Peter, S Morrill
PURPOSE: Hippocampus avoidance whole brain radiotherapy (HA-WBRT) has been shown to reduce the risk of neurocognitive dysfunction. This type of treatment has the potential of insurance company payment denial due to increased cost of intensity modulated radiotherapy (IMRT), while the accepted modality for WBRT is three-dimensional conformal radiotherapy (3DCRT). The purpose of this study is to assess HA-WBRT treatment plans using 3DCRT and multi-criteria optimization (MCO) that meets the RTOG 0933 criteria...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047564/su-f-j-221-adjusted-dose-and-its-relation-to-radiation-induced-liver-disease-during-hepatocellular-carcinoma-radiotherapy
#10
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of inter-fraction deformation during fractionated radiotherapy, which may result in difference from the planned dose. This study aimed to investigate the relationship between adjusted dose and radiation induced liver disease (RILD) in HCC patients receiving three dimensional conformal radiotherapy (3DCRT). METHODS: Twenty-three HCC patients received conventional fractionated 3DCRT were enrolled in this retrospective investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047553/su-f-t-686-considerations-about-dose-protraction-factor-in-tcp-calculations-for-prostate-vmat-treatments
#11
F Clemente, C Perez-Vara, M Clavo
PURPOSE: Dose protraction factor should be considered in order to model the TCP calculations. Nevertheless, this study describes a brief discussion showing that the lack of its inclusion should not invalidate these calculations for prostate VMAT treatments. METHODS: Dose protraction factor (G) modifies the quadratic term of the linear-quadratic expression in order to take into account the sublethal damage repair of protracting the dose delivery. If the delivery takes a short time (instantaneous), G = 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047281/su-f-t-204-a-preliminary-approach-of-reducing-contralateral-breast-and-heart-dose-in-left-sided-whole-breast-cancer-patients-utilizing-proton-beams
#12
M Islam, O Algan, H Jin, S Ahmad, S Hossain
PURPOSE: To investigate the plan quality and feasibility of a hybrid plan utilizing proton and photon fields for superior coverage in the internal mammary (IM) and supraclavicular (S/C) regions while minimizing heart and contralateral breast dose for the left-sided whole breast cancer patient treatment. METHODS: This preliminary study carried out on single left-sided intact breast patient involved IM and S/C nodes. The IM and S/C node fields of the 5-Field 3DCRT photon-electron base plan were replaced by two proton fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047201/su-f-t-432-magnetic-field-dose-effects-for-various-radiation-beam-geometries-for-patients-treated-with-hypofractionated-partial-breast-irradiation
#13
S Lim-Reinders, B Keller, C McCann, A Sahgal, J Lee, A Kim
PURPOSE: Hypofractionated partial breast irradiation (HPBI) is being used at our clinic to treat inoperable breast cancer patients who have advanced disease. We are investigating how these patients could benefit from being treated in an MRI-linac, where real-time daily MRI tumor imaging and plan adaptation would be possible. As a first step, this study evaluates the dosimetric impact of the magnetic field for different radiation beam geometries on relevant OARs. METHODS: Five patients previously treated using HPBI were selected...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046598/su-f-t-334-has-imrt-changed-the-impact-of-mlc-leaf-width-a-systematic-review-and-meta-analysis-of-tps-studies
#14
M Luzzara, L Santoro, K Brown
PURPOSE: We have performed a systematic review and meta-analysis in order to compare MLC leaf width used for different treatment techniques such as conformal and IMRT. METHODS: Medline and Google scholar databases have been searched using the "MLC leaf width" keywords with a cut-off date of 31st December 2015, considering only peer-reviewed papers. We have defined as intervention the MLC leaf width of 5 and 2.5 mm. We used the Conformity Index (CI) as the outcome subjected to the analysis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046524/su-f-t-502-fff-beams-jaw-tracking-and-treatment-techniques-out-of-field-dose-considerations-for-pediatric-radiation-therapy-delivery
#15
Y Ben Bouchta, A Bergman
PURPOSE: To compare the extended dose profile delivered by 3DCRT and VMAT techniques for flattened and flattening-filter-free(FFF) photon beams (6X, 6XFFF,10XFFF), with and without jaw-tracking (JT) on Varian TrueBeam linac. The goal is to determine which treatment technique/modality will minimize the peripheral photon dose exposure (and ultimately minimize the risk of second malignant neoplasms (SMN)) in pediatric patients. METHODS: 3DCRT, VMAT, and jaw tracking VMAT (JTVMAT) plans with 6X, 6XFFF and 10XFFF x-ray beams were created on a 30×60×22...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27981552/the-effect-of-three-dimensional-conformal-radiotherapy-on-locally-recurrent-nasopharyngeal-carcinoma-and-on-the-expression-of-succinate-dehydrogenase-b
#16
C-X Liu, H Wang, X-M Qian, F-X Lu, S-F Zhuang, M-X Yang, F-L Wang, Y-T Wang
OBJECTIVE: Investigate the effect of three-dimensional conformal radiotherapy (3DCRT) on locally recurrent nasopharyngeal carcinoma (NPC) on the expression of succinate dehydrogenase B (SDHB). PATIENTS AND METHODS: Eighty-six patients diagnosed with locally recurrent NPC in our hospital were selected and divided into the control group (43 cases) and observation group (43 cases). Conventional two-dimensional radiotherapy was applied in the control group, and 3DCRT was adopted in the observation group...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27942219/efficacy-of-three-dimensional-conformal-radiotherapy-combined-with-transarterial-chemoembolization-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#17
Fei-Xiang Wu, Hui-Rong Lu, Shao-Liang Zhu, Zi-Hui Li, Ling Zou, Tao Bai, Jie Chen, Tian-Bo Yang, Shi-Xiong Liang
OBJECTIVE: The current study aimed to evaluate the efficacy and outcomes of three-dimensional conformal radiotherapy (3DCRT) combined with transarterial chemoembolization (TACE) for treating patients with hepatocellular carcinoma involving portal vein tumor thrombus. METHODS: Between January 2000 and December 2013, a total of 182 hepatocellular carcinoma patients with portal vein tumor thrombus were retrospectively analyzed: 68 patients were treated by 3DCRT alone (group A), 74 by TACE alone (group B), and 40 by a combination of 3DCRT + TACE (group C)...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27920612/long-term-clinical-toxicity-of-radiation-therapy-in-prostate-cancer-patients-with-inflammatory-bowel-disease
#18
Matthew M Gestaut, Gregory P Swanson
AIM: The study's aim was to examine the clinical impact of radiation therapy (RT) on GI toxicity in Inflammatory Bowel Disease (IBD) patients. BACKGROUND: IBD has long been considered a risk factor for increased bowel toxicity from RT; however, minimal evidence exists on patients with prostate cancer (PC) and IBD. MATERIALS AND METHODS: The tumor registry was queried for patients with IBD and PC from the years 1990-2013. A retrospective review was conducted for patients who received RT...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27898748/-investigating-the-clinical-applicability-of-ebt2-self-developing-films
#19
Zsuzsánna Zongor, Dalma Béla, Réka Király, Gábor Stelczer, Tibor Major, Csilla Pesznyák
The purpose of the study was to investigate the physical properties of the EBT2 radiochromic films and define the conditions of its clinical applicability. We irradiated the films with different treatment techniques 3D conformal (3DCRT), intensity-modulated (IMRT) and stereotactic body radiotherapy with arc therapy (SBRT), and then compared the data with the dose distribution exported from the treatment planning system (Eclipse). Two film analysis softwares were investigated for the comparison: PTW Mephysto and FilmQA Pro...
November 29, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27891440/radiation-therapy-in-paediatric-orbital-granulocytic-sarcomas-experience-from-a-tertiary-cancer-center
#20
Sushmita Pathy, Bhanu Prasad Venkatesulu, Supriya Mallick, Subhash Chander
INTRODUCTION: Orbital Granulocytic Sarcoma (OGS) is an uncommon manifestation associated with haematological malignancies. Chemotherapy remains the cornerstone of the treatment. The role of radiation is not well-defined. AIM: To evaluate the effect of radiation in OGS and to define an optimal dose for achieving adequate local control. MATERIALS AND METHODS: This was a retrospective analysis of 11 patients who received radiation therapy to orbit for Granulocytic Sarcoma (GS) between 2007 and 2014 at a tertiary cancer center in India...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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