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3DCRT

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https://www.readbyqxmd.com/read/29764449/primo-software-as-a-tool-for-monte-carlo-simulations-of-intensity-modulated-radiotherapy-a-feasibility-study
#1
Alessandro Esposito, Sofia Silva, Jorge Oliveira, Joana Lencart, João Santos
BACKGROUND: IMRT provides higher dose conformation to the target and dose sparing to surrounding tissues than 3DCRT. Monte Carlo method in Medical Physics is not a novelty to approach dosimetric problems. A new PENELOPE based code named PRIMO recently was published. The most intriguing features of PRIMO are the user-friendly approach, the stand-alone property and the built-in definition of different linear accelerators models. Nevertheless, IMRT simulations are not yet implemented. METHODS: A Varian Trilogy with a Millennium120 MLC and a Varian Novalis with 120HD MLC were studied...
May 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29755767/utilization-of-neoadjuvant-intensity-modulated-radiation-therapy-and-proton-beam-therapy-for-esophageal-cancer-in-the-united-states
#2
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
Background: Randomized esophageal cancer (EC) trials have utilized two- or three-dimensional conformal radiotherapy (3DCRT). Advanced radiotherapy (RT) techniques [(ARTs): intensity-modulated radiotherapy (IMRT) and proton beam therapy (PBT)] may have benefits, but are relatively unproven. This is the first study to date evaluating utilization of ARTs versus 3DCRT in the trimodality setting in the United States. Methods: The National Cancer Data Base (NCDB) was queried (2004-2013) for newly-diagnosed cT1b-T4bN0/N+M0 EC receiving neoadjuvant CRT followed by esophagectomy...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29715118/utilization-of-neoadjuvant-intensity-modulated-radiation-therapy-for-rectal-cancer-in-the-united-states
#3
Taylor R Cushman, Sriram Venigalla, Eric D Brooks, Chi Lin, Vivek Verma
BACKGROUND/AIM: Advances in technology have expanded the use of intensity-modulated radiotherapy (IMRT). The goal of this study was to investigate trends in the utilization of IMRT for rectal cancer (RC) in USA. MATERIALS AND METHODS: The National Cancer Database was queried for RC patients receiving neoadjuvant chemoradiotherapy with either IMRT or three-dimensional conformal radiation therapy (3DCRT). Differences in factors associated with receipt of 3DCRT versus IMRT were determined and temporal trends were analyzed...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29682674/a-validation-study-of-a-dedicated-software-for-an-automated-in-vivo-dosimetry-control-in-radiotherapy
#4
A Piermattei, F Greco, M Grusio, S Menna, L Azario, G Stimato, E Placidi, S Teodoli, S Cilla, A Porcelli, L Alberico, A Fidanzio
In vivo dosimetry (IVD) is the last step of a radiotherapy quality control program aimed to ensure that the dose delivered is in agreement with that prescribed. IVD procedures based on single detectors are time-consuming and impossible to use for the modern radiotherapy techniques, based on static or kinetic beams (modulated in intensity fluence); this means that more efficient and practical methods are highly recommended. The practical method SOFTDISO, based on the use of electronic portal image device (EPID), provides two tests (i) the R ratio between the reconstructed and the planned isocenter doses to verify an agreement within 5% and (ii) the γ-analysis of the EPID images, to verify γ% ≥ 90% and γmean ≤ 0...
April 23, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29681771/dosimetry-of-the-left-anterior-descending-coronary-artery-in-left-breast-cancer-patients-treated-with-postoperative-external-radiotherapy
#5
Adela Poitevin-Chacón, Jessica Chávez-Nogueda, Rubí Ramos Prudencio, Alejandro Calvo Fernández, Alejandro Rodríguez Laguna, Jesús Linares, Julio César Martínez
Aim: To evaluate the dose distribution to the left anterior descending (LAD) coronary artery in patients treated with postoperative three-dimensional conformal radiotherapy (3DCRT). Background: Postoperative radiotherapy may increase the risk of heart disease, particularly in patients with left-sided breast cancer. Clinical data on doses to the LAD are limited. Materials and methods: Retrospective study of 14 patients who underwent postoperative 3DCRT for left breast cancer in 2014...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29655708/salivary-flow-rate-after-conventional-and-intensity-modulated-radiation-therapy
#6
Caroline Tram Nguyen, Spencer Lin, Haley Clark, Allan Hovan, Jonn Wu
BACKGROUND: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. In this study, the authors compared the salivary flow rate in patients receiving 3DCRT and those receiving IMRT and evaluated the effect of their treatment satisfying the QUANTEC guidelines on hyposalivation...
April 11, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29621872/dosimetric-comparison-of-imrt-versus-3dcrt-for-post-mastectomy-chest-wall-irradiation
#7
Kartick Rastogi, Shantanu Sharma, Shivani Gupta, Nikesh Agarwal, Sandeep Bhaskar, Sandeep Jain
PURPOSE: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. MATERIALS AND METHODS: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-Dnear-max (D2 ), Dnear-min (D98 ), Dmean , V95 , and V107 -homogeneity index (HI), and conformity index (CI) were compared...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29594584/genital-marginal-failures-after-intensity-modulated-radiation-therapy-imrt-in-squamous-cell-anal-cancer-no-higher-risk-with-imrt-when-compared-to-3dcrt
#8
V Dell'Acqua, J Kobiela, F Kraja, M C Leonardi, A Surgo, M A Zerella, S Arculeo, C Fodor, R Ricotti, M G Zampino, S Ravenda, G Spinoglio, R Biffi, A Bazani, R Luraschi, S Vigorito, P Spychalski, R Orecchia, R Glynne-Jones, B A Jereczek-Fossa
Intensity-modulated radiotherapy (IMRT) is considered the preferred option in squamous cell canal cancer (SCAC), delivering high doses to tumor volumes while minimizing dose to surrounding normal tissues. IMRT has steep dose gradients, but the technique is more demanding as deep understanding of target structures is required. To evaluate genital marginal failure in a cohort of patients with non-metastatic SCAC treated either with IMRT or 3DCRT and concurrent chemotherapy, 117 patients with SCAC were evaluated: 64 and 53 patients were treated with IMRT and 3DCRT techniques, respectively...
March 28, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29578185/hypofractionated-postoperative-irradiation-in-localized-renal-cell-cancer-a-case-report-and-pertinent-literature-review
#9
Xiang-Rong Zhao, Guang-Lian Shan, Yong Zhang, Yong-Hua Yu
For localized the incidence of renal cell carcinoma (RCC), nephrectomy is the standard treatment. As RCC is generally regarded as a radiation-resistant tumor, the value of postoperative adjuvant radiotherapy is controversial. However, with new advance in radiotherapy (i.e., three-dimensional conformal radiation therapy [3DCRT] and intensity-modulated radiation therapy [IMRT]), target volume delineation, intensity modulation in treatment planning, and treatment delivery are more accurate with fewer adverse effect...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29554287/intensity-modulated-radiotherapy-versus-three-dimensional-conformal-radiotherapy-in-rectal-cancer-treated-with-neoadjuvant-concurrent-chemoradiation-a-meta-analysis-and-pooled-analysis-of-acute-toxicity
#10
Chan Woo Wee, Hyun-Cheol Kang, Hong-Gyun Wu, Eui Kyu Chie, Noorie Choi, Jong Min Park, Jung-In Kim, Chun-Ming Huang, Jaw-Yuan Wang, Shu Y Ng, Karyn A Goodman
Background: To compare the acute gastrointestinal (GI) and genitourinary (GU) toxicity profiles between intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT) in rectal cancer patients treated with neoadjuvant chemoradiation (NCRT) using meta-analysis and pooled-analysis from published articles. Methods: Literature search was performed in PubMed and EMBASE from inception to March 2017. The odd ratios (ORs) were calculated and random effects model was used for meta-analysis...
March 15, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29553394/comparison-of-3dcrt-and-vmat-treatment-in-neoadjuvant-oesophageal-cancer
#11
O Santa Cruz, P Tsoutsou, M Schäfer, R Schneider, P Weber, G Guibert, C Tamburella, D Dragusanu, B Yanes, M Ozsahin
No abstract text is available yet for this article.
March 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29530433/inter-institutional-analysis-demonstrates-the-importance-of-lower-than-previously-anticipated-dose-regions-to-prevent-late-rectal-bleeding-following-prostate-radiotherapy
#12
Maria Thor, Andrew Jackson, Michael J Zelefsky, Gunnar Steineck, Asa Karlsdòttir, Morten Høyer, Mitchell Liu, Nicola J Nasser, Stine E Petersen, Vitali Moiseenko, Joseph O Deasy
PURPOSE: To investigate whether inter-institutional cohort analysis uncovers more reliable dose-response relationships exemplified for late rectal bleeding (LRB) following prostate radiotherapy. MATERIAL AND METHODS: Data from five institutions were used. Rectal dose-volume histograms (DVHs) for 989 patients treated with 3DCRT or IMRT to 70-86.4 Gy@1.8-2.0 Gy/fraction were obtained, and corrected for fractionation effects (α/β = 3 Gy). Cohorts with best-fit Lyman-Kutcher-Burman volume-effect parameter a were pooled after calibration adjustments of the available LRB definitions...
April 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29474098/comparing-four-radiotherapy-techniques-for-treating-the-chest-wall-plus-levels-iii-iv-draining-nodes-after-breast-reconstruction
#13
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Lorenzo Falcinelli, Claudio Zucchetti, Berardino de Bari, Simonetta Saldi, Cynthia Aristei
OBJECTIVE: To compare the dosimetric outcomes of four radiotherapy (RT) techniques for treating the chest wall plus draining nodes after mastectomy and breast reconstruction. METHODS: Three-dimensional conformal radiotherapy, linac-based intensity modulated RT, helical tomotherapy (HT) and direct tomotherapy treatments were planned for 40 breast cancer patients. Dose prescription was 50 Gy. Plans were compared in terms of doses to the planning target volume, organs at risk and the homogeneity index...
March 19, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29472076/robustness-of-vmat-and-3dcrt-plans-toward-setup-errors-in-radiation-therapy-of-locally-advanced-left-sided-breast-cancer-with-dibh
#14
Christer Andre Jensen, Ana María Acosta Roa, Marie Johansen, Jo-Åsmund Lund, Jomar Frengen
PURPOSE: The aim of our study was to evaluate and compare the robustness of treatment plans produced using the volumetric modulated arc-therapy (VMAT) and the standard three-dimensional conformal radiotherapy (3DCRT) techniques by estimating perturbed doses induced by localization offsets for deep inspiration breath-hold (DIBH) in locally advanced breast cancer radiation therapy. METHODS: Twenty patients with left breast carcinoma requiring radiation therapy were analysed in this planning study...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#15
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29426342/dosimetric-comparison-between-proton-beam-therapy-and-photon-radiation-therapy-for-locally-advanced-esophageal-squamous-cell-carcinoma
#16
Yasuhiro Hirano, Masakatsu Onozawa, Hidehiro Hojo, Atsushi Motegi, Sadatomo Zenda, Kenji Hotta, Shunsuke Moriya, Hidenobu Tachibana, Naoki Nakamura, Takashi Kojima, Tetsuo Akimoto
BACKGROUND: The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who were treated with PBT in our institution. In addition, we evaluated the correlation between toxicities and dosimetric parameters, especially the doses to normal lung or heart tissue, to clarify the clinical advantage of PBT over photon radiation therapy. METHODS: A total of 37 consecutive patients with Stage III thoracic ESCC who had received PBT with or without concurrent chemotherapy between October 2012 and December 2015 were evaluated in this study...
February 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29360138/interventions-to-reduce-acute-and-late-adverse-gastrointestinal-effects-of-pelvic-radiotherapy-for-primary-pelvic-cancers
#17
REVIEW
Theresa A Lawrie, John T Green, Mark Beresford, Linda Wedlake, Sorrel Burden, Susan E Davidson, Simon Lal, Caroline C Henson, H Jervoise N Andreyev
BACKGROUND: An increasing number of people survive cancer but a significant proportion have gastrointestinal side effects as a result of radiotherapy (RT), which impairs their quality of life (QoL). OBJECTIVES: To determine which prophylactic interventions reduce the incidence, severity or both of adverse gastrointestinal effects among adults receiving radiotherapy to treat primary pelvic cancers. SEARCH METHODS: We conducted searches of CENTRAL, MEDLINE, and Embase in September 2016 and updated them on 2 November 2017...
January 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29357886/modelling-the-immunosuppressive-effect-of-liver-sbrt-by-simulating-the-dose-to-circulating-lymphocytes-an-in-silico-planning-study
#18
L Basler, N Andratschke, S Ehrbar, M Guckenberger, S Tanadini-Lang
BACKGROUND: Tumor immune-evasion and associated failure of immunotherapy can potentially be overcome by radiotherapy, which however also has detrimental effects on tumor-infiltrating and circulating lymphocytes (CL). We therefore established a model to simulate the radiation-dose delivered to CL. METHODS: A MATLAB-model was established to quantify the CL-dose during SBRT of liver metastases by considering the factors: hepatic blood-flow, -velocity and transition-time of individual hepatic segments, as well as probability-based recirculation...
January 22, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29349933/patient-s-specific-integration-of-oar-doses-d2-cc-from-ebrt-and-3d-image-guided-brachytherapy-for-cervical-cancer
#19
Edgar Gelover, Cabel Katherine, Christopher Mart, Wenqing Sun, Yusung Kim
The objective of this study was to assess the recommended DVH parameter (e.g., D2 cc) addition method used for combining EBRT and HDR plans, against a reference dataset generated from an EQD2-based DVH addition method. A revised DVH parameter addition method using EBRT DVH parameters derived from each patient's plan was proposed and also compared with the reference dataset. Thirty-one biopsy-proven cervical cancer patients who received EBRT and HDR brachytherapy were retrospectively analyzed. A parametrial and/or paraaortic EBRT boost were clinically performed on 13 patients...
March 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29347960/long-term-outcome-of-definitive-radiotherapy-for-cervical-esophageal-squamous-cell-carcinoma
#20
Katsuyuki Sakanaka, Yuichi Ishida, Kota Fujii, Satoshi Itasaka, Shin'ichi Miyamoto, Takahiro Horimatsu, Manabu Muto, Takashi Mizowaki
BACKGROUND: The aim of this study was to identify the long-term clinical outcome of definitive radiotherapy using three-dimensional conformal radiotherapy (3DCRT) for cervical esophageal squamous cell carcinoma (CESCC). METHODS: We retrospectively reviewed the medical records of 30 patients with CESCC [clinical stage I/II/III/IV(M1LYM); 3/2/12/13] (TNM 7th edition) who underwent definitive radiotherapy using 3DCRT between 2000 and 2014 in our institution. The median prescribed dose for the gross tumor and metastatic lymph nodes was 60 Gy...
January 18, 2018: Radiation Oncology
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