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3DCRT

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https://www.readbyqxmd.com/read/29349933/patient-s-specific-integration-of-oar-doses-d2%C3%A2-cc-from-ebrt-and-3d-image-guided-brachytherapy-for-cervical-cancer
#1
Edgar Gelover, Cabel Katherine, Christopher Mart, Wenqing Sun, Yusung Kim
The objective of this study was to assess the recommended DVH parameter (e.g., D2 cc) addition method used for combining EBRT and HDR plans, against a reference dataset generated from an EQD2-based DVH addition method. A revised DVH parameter addition method using EBRT DVH parameters derived from each patient's plan was proposed and also compared with the reference dataset. Thirty-one biopsy-proven cervical cancer patients who received EBRT and HDR brachytherapy were retrospectively analyzed. A parametrial and/or paraaortic EBRT boost were clinically performed on 13 patients...
January 19, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29347960/long-term-outcome-of-definitive-radiotherapy-for-cervical-esophageal-squamous-cell-carcinoma
#2
Katsuyuki Sakanaka, Yuichi Ishida, Kota Fujii, Satoshi Itasaka, Shin'ichi Miyamoto, Takahiro Horimatsu, Manabu Muto, Takashi Mizowaki
BACKGROUND: The aim of this study was to identify the long-term clinical outcome of definitive radiotherapy using three-dimensional conformal radiotherapy (3DCRT) for cervical esophageal squamous cell carcinoma (CESCC). METHODS: We retrospectively reviewed the medical records of 30 patients with CESCC [clinical stage I/II/III/IV(M1LYM); 3/2/12/13] (TNM 7th edition) who underwent definitive radiotherapy using 3DCRT between 2000 and 2014 in our institution. The median prescribed dose for the gross tumor and metastatic lymph nodes was 60 Gy...
January 18, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29329660/cochlea-ct-radiomics-predicts-chemoradiotherapy-induced-sensorineural-hearing-loss-in-head-and-neck-cancer-patients-a-machine-learning-and-multi-variable-modelling-study
#3
Hamid Abdollahi, Shayan Mostafaei, Susan Cheraghi, Isaac Shiri, Seied Rabi Mahdavi, Anoshirvan Kazemnejad
OBJECTIVES: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. MATERIAL AND METHODS: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection operator (LASSO) penalized logistic regression were implemented on radiomic features for feature selection, classification and prediction...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29282078/short-course-hypofractionated-whole-breast-irradiation-after-conservative-surgery-a-single-institution-phase-ii-study
#4
Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari, Giuseppe Sanguineti
BACKGROUND: To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI). METHODS: Eligible patients had undergone breast conservative surgery for early breast cancer (pTis-2) and none/limited nodal involvement. Hypo-WBI consisted of 34 Gy in 10 daily fractions over 2 weeks to the whole breast three-dimensional conformal radiotherapy (3DCRT), followed by a single fraction of 8 Gy to the tumor bed after 1 week (electrons). Primary endpoint is freedom from ipsilateral breast tumor recurrence (IBTR)...
December 27, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29237970/a-dosimetric-comparison-between-three-dimensional-conformal-radiation-therapy-and-intensity-modulated-radiation-therapy-in-the-treatment-of-posterior-fossa-boost-in-medulloblastoma
#5
Meenu Gupta, Ravi Kant, Vipul Nautiyal, Jyoti Bisht, Shalindra Raghuvanshi, Manju Saini, B P Kalra, Mushtaq Ahmad
AIMS: To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DESIGN: Structured. SUBJECTS AND METHODS: Seven previously irradiated patients of MB were retrieved and re-planned with both 3DCRT and IMRT techniques...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29233562/comparison-of-radiation-therapy-modalities-for-hepatocellular-carcinoma-with-portal-vein-thrombosis-a-meta-analysis-and-systematic-review
#6
Chai Hong Rim, Chul Yong Kim, Dae Sik Yang, Won Sup Yoon
PURPOSE: We performed a meta-analysis and systematic review to compare the radiotherapy (RT) modalities for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT). MATERIALS AND METHODS: We searched the PubMed, EMBASE, Medline, and Cochrane library databases. The primary endpoint was the 1-year overall survival (OS), and response rate (RR), local control (LC), 2-year OS, and grade ≥3 toxicity incidence were evaluated as secondary endpoints. RESULTS: Thirty-seven studies comprising 2513 patients were included...
December 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29198389/cumulative-dose-of-radiation-therapy-of-hepatocellular-carcinoma-patients-and-its-deterministic-relation-to-radiation-induced-liver-disease
#7
Pu Huang, Gang Yu, Daniel S Kapp, Xue-Feng Bian, Chang-Sheng Ma, Hong-Sheng Li, Jin-Hu Chen, Yue-Qiang Liang, Yang Zhang, Shao-Hua Qin, Yao-Qin Xie, Yong Yang, Yong Yin, Lei Xing, Deng-Wang Li
This study aimed to investigate the relationship between dose and radiation-induced liver disease (RILD) in patients with hepatocellular carcinoma (HCC) receiving 3-dimensional conformal radiotherapy (3DCRT). Twenty-three patients with HCC who received conventional fractionated 3DCRT, including 7 who were diagnosed with classic RILD, were enrolled in this retrospective investigation. Cone-beam computed tomography (CBCT) scans were acquired at the time of treatment for each patient. The beams from each patient's treatment plan were applied to each pretreatment CBCT (the modified CBCT or mCBCT) to construct the delivered dose distribution of the day considering inter-treatment anatomy changes...
November 29, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29166133/dosimetric-impact-of-gastrointestinal-air-column-in-radiation-treatment-of-pancreatic-cancer
#8
Neil C Estabrook, Jonathan B Corn, Marvene E Ewing, Higinia R Cardenes, Indra J Das
OBJECTIVE: Dosimetric evaluation of air column in gastro-intestinal (GI) structures in IMRT of pancreatic cancer. METHODS: Nine sequential patients were retrospectively chosen for dosimetric analysis of air column in the GI apparatus in pancreatic cancer using cone beam CT (CBCT). The 4DCT was used for target and organs at risk (OARs) and non-coplanar IMRT was used for treatment. Once/week, these patients underwent CBCT for air filling, isocenter verification and dose calculations retrospectively...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29114609/dose-escalation-with-an-imrt-technique-in-15-to-28-fractions-is-better-tolerated-than-standard-doses-of-3dcrt-for-lapc
#9
Lauren E Colbert, Shalini Moningi, Awalpreet Chadha, Ahmed Amer, Yeonju Lee, Robert A Wolff, Gauri Varadhachary, Jason Fleming, Matthew Katz, Prajnan Das, Sunil Krishnan, Eugene J Koay, Peter Park, Christopher H Crane, Cullen M Taniguchi
Purpose: To review acute and late toxicities after chemoradiation for locally advanced pancreatic ductal adenocarcinoma in patients who were treated with escalated dose radiation (EDR). Methods and materials: Maximum Common Terminology Criteria for Adverse Events Version 4.0 acute toxicities (AT) during radiation and within 60 days after radiation were recorded for both acute gastrointestinal toxicity and overall toxicity (OT). Late toxicities were also recorded...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29110673/clinical-outcomes-of-graves-ophthalmopathy-treated-with-intensity-modulated-radiation-therapy
#10
Yong-Jiang Li, Yong Luo, Wei-Min He, Ping Li, Feng Wang
BACKGROUND: Radiation for Graves' ophthalmopathy (GO) has traditionally utilized lateral opposing fields (LOF) or three-dimensional conformal radiotherapy (3DCRT) technique. The current study was conducted to report clinical outcomes and therapeutic effects of intensity modulated radiation therapy (IMRT) in treating GO patients. METHODS: One hundred sixteen patients with GO were treated with IMRT as initial local therapy between July 2010 and August 2013, with a median follow-up of 62 months (range 45-81 months)...
November 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29108367/comparison-on-efficacy-of-radical-prostatectomy-versus-external-beam-radiotherapy-for-the-treatment-of-localized-prostate-cancer
#11
Linyan Chen, Qingfang Li, Yexiao Wang, Yiwen Zhang, Xuelei Ma
Since there was no consensus on treatment options of localized prostate cancer, a meta-analysis was performed to compare the efficacy of radical prostatectomy (RP) versus external beam radiotherapy (EBRT) concluding three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT). The search of eligible studies was performed on PubMed and Embase databases. The overall survival (OS), cancer-specific survival (CSS) and biochemical disease-free survival (BDFS) were compared by hazard ratio (HR) and odd ratios (OR)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29101643/dosimetric-comparison-of-3-dimensional-conformal-radiotherapy-volumetric-modulated-arc-therapy-and-helical-tomotherapy-for-postoperative-gastric-cancer-patients
#12
Cem Onal, Yemliha Dölek, Berna Akkuş Yıldırım
PURPOSE: To compare dosimetric data for the planning target volume (PTV) and organs at risk (OARs) between 3-dimensional conformal radiotherapy (3DCRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy [1]. MATERIALS AND METHODS: The dosimetric data for 15 gastric cancer patients treated with 3DCRT, VMAT, or HT techniques were used. Cumulative dosimetric parameters, homogeneity index (HI), and conformal index (CI) were compared for the PTV and OARs...
November 3, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29097074/a-phase-ii-toxicity-end-point-trial-icorg-99-09-of-accelerated-dose-escalated-hypofractionated-radiation-in-non-small-cell-lung-cancer
#13
D N Cagney, P G Thirion, M T Dunne, C Fleming, D Fitzpatrick, C M O'Shea, M A Finn, S O'Sullivan, C Booth, C D Collins, S J Buckney, A Shannon, J G Armstrong
AIMS: The objective of this phase II clinical trial was to prospectively evaluate the safety and efficacy of accelerated hypofractionated three-dimensional conformal radiation therapy (3DCRT) in localised non-resectable/non-operable non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Sixty patients with stage I-III NSCLC were enrolled in a prospective single-arm All Ireland Co-operative Oncology Research Group (ICORG 99-09) toxicity end point phase II trial...
October 30, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28988893/radiation-therapy-of-synchronous-bilateral-breast-carcinoma-sbbc-using-multiple-techniques
#14
Sung Jin Kim, Mi Jo Lee, Seon Min Youn
The purpose of this study was to establish intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans for synchronous bilateral breast cancer (SBBC) and to compare those plans with the previous treatment plans using 3D conformal radiation therapy (3DCRT). The differences among the treatments were also statistically compared regarding dosimetry distribution and treatment efficiency. The research was conducted with 10 SBBC patients. The study established IMRT (12 fields with a single isocenter) and VMAT (2 partial arcs with a single isocenter) treatment plans for SBBC patients and then compared those plans with 3DCRT (8 fields with multiple isocenters)...
October 5, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28984841/can-intensity-modulated-radiotherapy-reduce-toxicity-in-head-and-neck-squamous-cell-carcinoma
#15
REVIEW
Julie van der Veen, Sandra Nuyts
Intensity modulated radiotherapy (IMRT) is a modern radiotherapy technique that was implemented in the mid-1990s. It allows closer shaping of dose, to target volumes, thereby sparing organs at risk (OARs). Before the IMRT-era, two-dimensional radiotherapy (2DRT) and later three-dimensional conformal radiotherapy (3DCRT) were the techniques of choice, but this robust way of irradiating caused more normal tissue to receive a higher dose. Radiation of cancers in the head and neck region is complex because of close proximity to critical normal tissue and the large target volumes that need to be treated at high doses...
October 6, 2017: Cancers
https://www.readbyqxmd.com/read/28984517/intermediate-risk-meningioma-initial-outcomes-from-nrg-oncology-rtog-0539
#16
Leland Rogers, Peixin Zhang, Michael A Vogelbaum, Arie Perry, Lynn S Ashby, Jignesh M Modi, Anthony M Alleman, James Galvin, David Brachman, Joseph M Jenrette, John De Groot, Joseph A Bovi, Maria Werner-Wasik, Jonathan P S Knisely, Minesh P Mehta
OBJECTIVE This is the first clinical outcomes report of NRG Oncology RTOG 0539, detailing the primary endpoint, 3-year progression-free survival (PFS), compared with a predefined historical control for intermediate-risk meningioma, and secondarily evaluating overall survival (OS), local failure, and prospectively scored adverse events (AEs). METHODS NRG Oncology RTOG 0539 was a Phase II clinical trial allocating meningioma patients to 1 of 3 prognostic groups and management strategies according to WHO grade, recurrence status, and resection extent...
October 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28979889/comparative-analysis-of-efficacy-toxicity-and-patient-reported-outcomes-in-rectal-cancer-patients-undergoing-preoperative-3d-conformal-radiotherapy-or-vmat
#17
Antonia Regnier, Jana Ulbrich, Stefan Münch, Markus Oechsner, Dirk Wilhelm, Stephanie E Combs, Daniel Habermehl
BACKGROUND: Locally advanced rectal cancer (LARC) patients are usually treated within a multimodal therapy regime, in which the tumor resection plays the major role. This treatment ideally includes 5-fluorouracile (5FU)-based chemoradiation (CRT) leading to significantly improved local control rates. Local therapy as radiotherapy (RT) is required to be adapted referring to side effects and efficacy. Purpose of this study is the comparison of dosimetric parameters, acute and late toxicity, and quality of life in terms of patient-reported outcome (PRO) in patients treated with VMAT or 3D conformal radiotherapy (3DCRT) for LARC...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28974856/cardiac-dose-reduction-with-deep-inspiratory-breath-hold-technique-of-radiotherapy-for-left-sided-breast-cancer
#18
Lalitha Kameshwari Sripathi, Parveen Ahlawat, David K Simson, Chira Ranjan Khadanga, Lakshmipathi Kamarsu, Shital Kumar Surana, Kavi Arasu, Harpreet Singh
INTRODUCTION: Different techniques of radiation therapy have been studied to reduce the cardiac dose in left breast cancer. AIM: In this prospective dosimetric study, the doses to heart as well as other organs at risk (OAR) were compared between free-breathing (FB) and deep inspiratory breath hold (DIBH) techniques in intensity modulated radiotherapy (IMRT) and opposed-tangent three-dimensional radiotherapy (3DCRT) plans. MATERIALS AND METHODS: Fifteen patients with left-sided breast cancer underwent computed tomography simulation and images were obtained in both FB and DIBH...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28947989/intensity-modulated-radiotherapy-has-superior-outcomes-to-three-dimensional-conformal-radiotherapy-in-patients-with-stage-ie-iie-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#19
Yi-Yang Li, Hai-Qun Lin, Lu-Lu Zhang, Ling-Ling Feng, Shao-Qing Niu, Han-Yu Wang, Yu-Jing Zhang, Xi-Cheng Wang
We compared the treatment outcomes, toxicities and prognoses of patients with stage IE-IIE extranodal natural killer/T-cell lymphoma (ENKTL) treated with intensity-modulated radiotherapy (IMRT) or three-dimensional conformal radiotherapy (3DCRT). Newly diagnosed early-stage ENKTL patients (N = 173) were enrolled and received extended involved-field radiotherapy following induction chemotherapy. Patients were treated with 3DCRT (n = 98) or IMRT (n = 75). One-to-one matching of the IMRT and 3DCRT groups was performed through propensity score matching, which yielded 23 pairs of patients...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938697/intensity-modulated-radiotherapy-for-hepatocellular-carcinoma-dosimetric-and-clinical-results
#20
REVIEW
Sun Hyun Bae, Won Il Jang, Hee Chul Park
Since the introduction of 3-dimensional conformal radiotherapy (3DCRT), new radiotherapy techniques have expanded the indication of radiotherapy for the treatment of hepatocellular carcinoma (HCC), from the hitherto palliative to a now curative-intent purpose. Intensity-modulated radiotherapy (IMRT), currently the most advanced radiotherapy technique, is considered an attractive option for the treatment of HCC, and is more widely applied because it can deliver a higher dose to the tumor than 3DCRT while sparing surrounding normal organs...
August 29, 2017: Oncotarget
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