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neutropenic enterocolitis

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https://www.readbyqxmd.com/read/29675758/the-prognostic-impact-of-abdominal-surgery-in-cancer-patients-with-neutropenic-enterocolitis-a-systematic-review-and-meta-analysis-on-behalf-the-groupe-de-recherche-en-r%C3%A3-animation-respiratoire-du-patient-d-onco-h%C3%A3-matologie-grrr-oh
#1
REVIEW
Colombe Saillard, Lara Zafrani, Michael Darmon, Magali Bisbal, Laurent Chow-Chine, Antoine Sannini, Jean-Paul Brun, Jacques Ewald, Olivier Turrini, Marion Faucher, Elie Azoulay, Djamel Mokart
Neutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. This review and meta-analysis aimed to determine the prognostic impact of abdominal surgery on outcome of neutropenic cancer patients presenting with NE, versus medical conservative treatment...
April 19, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29561309/acute-myositis-an-unusual-and-severe-side-effect-of-docetaxel-a-case-report-and-literature-review
#2
Philippe Rochigneux, Nicolas Schleinitz, Mikael Ebbo, Marie Aymonier, Bertrand Pourroy, Romain Boissier, Sébastien Salas, Jean-Laurent Deville
Docetaxel is an antimicrotubules cytotoxic agent prescribed widely by medical oncologists in multiple tumor types (breast, lung, prostate, stomach, head, and neck). However, the side effects of docetaxel are numerous (cytopenia, peripheral edema, myalgia, arthralgia, alopecia, and sensitive neuropathy) and recent concerns have been raised about neutropenic enterocolitis in France. Here, we report the case of a 57-year-old patient with metastatic prostatic cancer, who developed a severe myositis and fasciitis grade IV 1 week after his second docetaxel infusion...
March 20, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29065118/a-fresh-look-at-polymicrobial-bloodstream-infection-in-cancer-patients
#3
Cristina Royo-Cebrecos, Carlota Gudiol, Carmen Ardanuy, Helena Pomares, Mariona Calvo, Jordi Carratalà
OBJECTIVES: To assess the current incidence, clinical features, risk factors, aetiology, antimicrobial resistance and outcomes of polymicrobial bloodstream infection (PBSI) in patients with cancer. METHODS: All prospectively collected episodes of PBSI in hospitalised patients were compared with episodes of monomicrobial bloodstream infection (MBSI) between 2006 and 2015. RESULTS: We identified 194 (10.2%) episodes of PBSI and 1702 MBSI (89...
2017: PloS One
https://www.readbyqxmd.com/read/28842139/daunorubicin-90-mg-m2-in-acute-myeloid-leukemia-induction-increased-toxicity-in-young%C3%A2-patients
#4
Rodrigo Portugal, Renata Lyrio, Monique Loureiro, Kátia Urago, Johny Bard, Aline Borchardt, Márcia Garnica, Márcio Nucci
BACKGROUND: The combination of an anthracycline and cytosine arabinoside has been the standard induction therapy for acute myeloid leukemia for more than 3 decades. The clinical benefit of intensification of the daunorubicin dose to 90 mg/m2 has been supported by randomized trials. Based on these promising results, in 2010 we changed our induction protocol of acute myeloid leukemia, increasing the dose of daunorubicin. PATIENTS AND METHODS: We retrospectively analyzed the treatment outcome of patients treated with high-dose daunorubicin (90 mg/m2 on days 1-3) and cytosine arabinoside (200 mg/m2/day continuous infusion on days 1-7) compared with patients receiving 45 to 60 mg/m2 of daunorubicin...
August 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28664544/neutropenic-enterocolitis-typhlitis-in-a-pediatric-renal-transplant-patient-a-case-report-and-review-of-the-literature
#5
Jonathan H Pelletier, Shashi Nagaraj, Rasheed Gbadegesin, Delbert Wigfall, Kathleen A McGann, John Foreman
NE (typhlitis) is a potentially life-threatening disease process characterized by bowel wall edema, ulceration, and hemorrhage in an immunosuppressed patient. We report a 15-year-old boy status post deceased donor renal transplantation who presented with fever, abdominal pain, and diarrhea. Laboratory studies revealed neutropenia 5 days prior to admission, and abdominal computed tomography revealed bowel wall thickening in the cecum consistent with NE. He was treated with piperacillin-tazobactam and gentamicin and recovered...
September 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28601903/can-complications-in-febrile-neutropenia-be-predicted-report-from-a-developing-country
#6
Sapna Oberoi, Anirban Das, Amita Trehan, Pallab Ray, Deepak Bansal
PURPOSE: Febrile neutropenia (FN) is an important cause of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). We aimed to look at complications in febrile neutropenia and to derive a risk model for developing complications from the variables predicting complications. METHODS: Children on treatment for ALL, presenting with FN, were prospectively enrolled over a period of 1 year. Their clinical presentation, course during hospital stay, and outcomes were recorded...
November 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28556623/ultrasonography-driven-combination-antibiotic-therapy-with-tigecycline-significantly-increases-survival-among-patients-with-neutropenic-enterocolitis-following-cytarabine-containing-chemotherapy-for-the-remission-induction-of-acute-myeloid-leukemia
#7
Novella Pugliese, Paola Salvatore, Dora Vita Iula, Maria Rosaria Catania, Federico Chiurazzi, Roberta Della Pepa, Claudio Cerchione, Marta Raimondo, Claudia Giordano, Luigia Simeone, Simona Caruso, Fabrizio Pane, Marco Picardi
Neutropenic enterocolitis (NEC) is an abdominal infection reported primarily in patients with acute myeloid leukemia (AML) following chemotherapy, especially cytarabine, a notable efficacious cytotoxic agent for AML remission. Specific data regarding the impact of different cytarabine schedules and/or antibacterial regimens for NEC are sparse. The aim of the study was to identify the predictors of outcome within 30 days of NEC onset. NEC episodes were retrospectively pinpointed among 440 patients with newly diagnosed AML hospitalized in our Institution, over a 10-year period, for receiving chemotherapy protocols with 100-6000 mg/m2 daily of cytarabine...
July 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28363097/gastrointestinal-emergencies-in-critically-ill-cancer-patients
#8
Delphine Lebon, Lucie Biard, Sophie Buyse, David Schnell, Etienne Lengliné, Camille Roussel, Jean-Marc Gornet, Nicolas Munoz-Bongrand, Laurent Quéro, Matthieu Resche-Rigon, Elie Azoulay, Emmanuel Canet
PURPOSE: To describe gastrointestinal emergencies in cancer patients. METHODS: All cancer patients admitted to the medical ICU of Saint-Louis Hospital for an acute abdominal syndrome during the study period (1997-2011) were included. RESULTS: A total of 164 patients were included. The most common diagnoses were: neutropenic enterocolitis (NE) (n=54, 33%), infectious colitis and peritonitis (n=51, 31%), bowel infiltration by malignancy (n=14, 9%), and mucosal toxicity of chemotherapy (n=12, 7%)...
August 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28160269/infections-in-cancer-patients-with-solid-tumors-a-review
#9
REVIEW
Kenneth V I Rolston
Solid tumors are much more common than hematologic malignancies. Although severe and prolonged neutropenia is uncommon, several factors increase the risk of infection in patients with solid tumors, and the presence of multiple risk factors in the same patient is not uncommon. These include obstruction (most often caused by progression of the tumor), disruption of natural anatomic barriers such as the skin and mucosal surfaces, and treatment-related factors such as chemotherapy, radiation, diagnostic and/or therapeutic surgical procedures, and the increasing use of medical devices such as various catheters, stents, and prostheses...
March 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28104979/neutropenic-enterocolitis
#10
REVIEW
Fabio G Rodrigues, Giovanna Dasilva, Steven D Wexner
Neutropenic colitis is a severe condition usually affecting immunocompromised patients. Its exact pathogenesis is not completely understood. The main elements in disease onset appear to be intestinal mucosal injury together with neutropenia and the weakened immune system of the afflicted patients. These initial conditions lead to intestinal edema, engorged vessels, and a disrupted mucosal surface, which becomes more vulnerable to bacterial intramural invasion. Chemotherapeutic agents can cause direct mucosal injury (mucositis) or can predispose to distension and necrosis, thereby altering intestinal motility...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28075196/typhlitis-neutropenic-enterocolitis-in-patients-with-acute-leukemia-a-review
#11
REVIEW
Rodrigo Portugal, Marcio Nucci
Typhlitis is an abdominal complication of cancer chemotherapy, affecting mostly patients receiving intensive chemotherapeutic regimens with high potential to induce mucosal damage, such as patients with acute leukemia. Despite being relatively frequent, there are no randomized trials or high-quality cohort studies addressing important aspects of the diagnosis and management of the disease. Areas covered: In this review we discuss the gaps in the literature, acknowledging that the evidences for recommendations regarding the management of typhlitis are mostly expert opinion...
February 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/27803612/painless-neutropenic-enterocolitis-in-a-patient-undergoing-chemotherapy
#12
E J Chow, K D Bishop
CASE DESCRIPTION: A 60-year-old man developed painless neutropenic enterocolitis after induction chemotherapy for newly diagnosed acute myelogenous leukemia. The patient had recurrent fever while neutropenic, without experiencing abdominal pain or tenderness on physical examination. His diagnosis was delayed by the fact that he had no localizing symptoms. DISCUSSION: Neutropenic enterocolitis is a common complication, generally occurring in patients who are severely neutropenic; the condition presents with fever and abdominal pain...
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27599654/an-unusual-presentation-of-neutropenic-enterocolitis-typhlitis
#13
Jonathan Youngs, Cristina Suarez, Mickey B C Koh
No abstract text is available yet for this article.
May 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27531123/hypogammaglobulinemia-and-poor-performance-status-are-predisposing-factors-for-vancomycin-resistant-enterococcus-colonization-in-patients-with-hematological-malignancies
#14
Elif Gülsüm Ümit, Figen Kuloğlu, Ahmet Muzaffer Demir
OBJECTIVE: Vancomycin-resistant enterococci (VRE) are common pathogens of hospital-acquired infection. Long hospitalization periods, use of broad-spectrum antibiotics, and immunosuppression are major risks for VRE colonization. We aimed to evaluate patients' characteristics and factors that may contribute to VRE colonization. MATERIALS AND METHODS: Data of 66 patients with colonization and 112 patients without colonization who were hospitalized in the hematology clinic were collected...
March 1, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27433098/gastrointestinal-and-liver-infections-in-children-undergoing-antineoplastic-chemotherapy-in-the-years-2000
#15
REVIEW
Elio Castagnola, Eliana Ruberto, Alfredo Guarino
AIM: To review gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy. To look at gut microflora features in oncology children. METHODS: We selected studies published after year 2000, excluding trials on transplanted pediatric patients. We searched English language publications in MEDLINE using the keywords: "gastrointestinal infection AND antineoplastic chemotherapy AND children", "gastrointestinal infection AND oncology AND children", "liver infection AND antineoplastic chemotherapy AND children", "liver abscess AND chemotherapy AND child", "neutropenic enterocolitis AND chemotherapy AND children", "thyphlitis AND chemotherapy AND children", "infectious diarrhea AND children AND oncology", "abdominal pain AND infection AND children AND oncology", "perianal sepsis AND children AND oncology", "colonic pseudo-obstruction AND oncology AND child AND chemotherapy", "microflora AND children AND malignancy", "microbiota AND children AND malignancy", "fungal flora AND children AND malignancy"...
July 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26459642/early-onset-neutropenia-in-small-for-gestational-age-infants
#16
Robert D Christensen, Bradley A Yoder, Vickie L Baer, Gregory L Snow, Allison Butler
BACKGROUND: Early neutropenia is more common in small for gestational age (SGA) neonates (birth weight <10th percentile) than in appropriately grown neonates. However, several aspects of this variety of neutropenia are unknown, including the duration, kinetic mechanism, and outcomes. METHODS: Using 10 years of multihospital records, we studied SGA neonates who, during the first week after birth, had neutrophil counts <1000/μL. RESULTS: This degree of neutropenia was more common in SGA neonates (6%, 207/3650) than in non-SGA matched controls (1%, 46/3650; P < ...
November 2015: Pediatrics
https://www.readbyqxmd.com/read/26298799/-ipilimumab-induced-colitis-a-new-challenge-for-gastroenterologists
#17
REVIEW
Francisco Mesonero, Antonio López-Sanromán, Ainhoa Madariaga, Ainara Soria
Many drugs can produce enterocolitis and they should always be included in the differential diagnosis of this clinical picture. Entities such as antibiotic-associated colitis and neutropenic colitis have been known for some time and recently a new type of drug-induced colitis has emerged due to monoclonal antibodies. Ipimumab is a humanized monoclonal antibody against the CTLA4 molecule that is involved in the maturation and regulation of T lymphocyte activation. This drug causes immune activation and has an immune-mediated antitumor effect with excellent results in tumours such as melanoma...
March 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/26281844/a-multidisciplinary-approach-to-perianal-and-intra-abdominal-infections-in-the-neutropenic-cancer-patient
#18
REVIEW
Patrick S Sullivan, Courtney Moreno
The chemotherapeutic treatment of both hematologic and solid organ malignancies has increased in recent decades, resulting in increased neutropenia-related perianal and intra-abdominal infections. Nearly 30% of neutropenia-related infections arise in the gastrointestinal tract. The management of these patients is often not straightforward, and the indications for and timing of surgical intervention continue to be unclear. The management strategy must take into account such factors as recent chemotherapy toxicity, stage and prognosis of the malignancy, performance status, comorbidities, degree of neutropenia, immunosuppression, thrombocytopenia, and corticosteroid use...
August 2015: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/26034404/noninfectious-colitides
#19
REVIEW
Mohammed Bayasi, Jose Quiogue
There are numerous etiologic and pathogenic mechanisms associated with colitis, ranging from infectious to noninfectious colitis. However, despite their different causes, their presentations are often similar making it difficult to formulate the correct diagnosis. This article describes the presentation, endoscopic and pathological findings of six different noninfectious colitides: diversion colitis, neutropenic enterocolitis, disinfectant colitis, corrosive colitis, nonsteroidal anti-inflammatory drug and salicylate-induced colitis, and toxic epidermal necrolysis...
June 2015: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/25813206/clinical-features-of-life-threatening-complications-following-autologous-stem-cell-transplantation-in-patients-with-lymphoma
#20
Lionel Kerhuel, Sandy Amorim, Elie Azoulay, Catherine Thiéblemont, Emmanuel Canet
Toxic effects of high dose therapy (HDT) combined with autologous stem cell transplantation (ASCT) can lead to life-threatening conditions that may require intensive care unit (ICU) admission. We conducted a retrospective observational study over a 10-year period of all patients admitted to the ICU within 3 months after HDT/ASCT for lymphoma. Among the 532 patients treated by HDT/ASCT at our hospital, 27 (5%) were admitted to the ICU. Infections accounted for 88% (n = 24) of diagnoses, in whom 50% were microbiologically documented...
2015: Leukemia & Lymphoma
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