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neutropenic enterocolitis

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https://www.readbyqxmd.com/read/27803612/painless-neutropenic-enterocolitis-in-a-patient-undergoing-chemotherapy
#1
E J Chow, K D Bishop
CASE DESCRIPTION: A 60-year-old man developed painless neutropenic enterocolitis after induction chemotherapy for newly diagnosed acute myelogenous leukemia. The patient had recurrent fever while neutropenic, without experiencing abdominal pain or tenderness on physical examination. His diagnosis was delayed by the fact that he had no localizing symptoms. DISCUSSION: Neutropenic enterocolitis is a common complication, generally occurring in patients who are severely neutropenic; the condition presents with fever and abdominal pain...
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27599654/an-unusual-presentation-of-neutropenic-enterocolitis-typhlitis
#2
Jonathan Youngs, Cristina Suarez, Mickey B C Koh
No abstract text is available yet for this article.
May 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27531123/hypogammaglobulinemia-and-poor-performance-status-are-predisposing-factors-for-vancomycin-resistant-enterococcus-colonization-in-patients-with-hematological-malignancies
#3
Elif Gülsüm Ümit, Figen Kuloğlu, Ahmet Muzaffer Demir
BACKGROUND: Vancomycin resistant enterococci (VRE) are common pathogens of hospital-acquired infection. Long hospitalization periods, use of broad-spectrum antibiotics and immunosuppression are major risks for VRE colonization. AIMS: We aimed to evaluate patients' characteristics and factors which may contribute to VRE colonization. METHODS: Data of 66 patients with colonization and 112 patients without colonization who have been hospitalized in the Hematology clinic were collected...
August 16, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27433098/gastrointestinal-and-liver-infections-in-children-undergoing-antineoplastic-chemotherapy-in-the-years-2000
#4
Elio Castagnola, Eliana Ruberto, Alfredo Guarino
AIM: To review gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy. To look at gut microflora features in oncology children. METHODS: We selected studies published after year 2000, excluding trials on transplanted pediatric patients. We searched English language publications in MEDLINE using the keywords: "gastrointestinal infection AND antineoplastic chemotherapy AND children", "gastrointestinal infection AND oncology AND children", "liver infection AND antineoplastic chemotherapy AND children", "liver abscess AND chemotherapy AND child", "neutropenic enterocolitis AND chemotherapy AND children", "thyphlitis AND chemotherapy AND children", "infectious diarrhea AND children AND oncology", "abdominal pain AND infection AND children AND oncology", "perianal sepsis AND children AND oncology", "colonic pseudo-obstruction AND oncology AND child AND chemotherapy", "microflora AND children AND malignancy", "microbiota AND children AND malignancy", "fungal flora AND children AND malignancy"...
July 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26459642/early-onset-neutropenia-in-small-for-gestational-age-infants
#5
Robert D Christensen, Bradley A Yoder, Vickie L Baer, Gregory L Snow, Allison Butler
BACKGROUND: Early neutropenia is more common in small for gestational age (SGA) neonates (birth weight <10th percentile) than in appropriately grown neonates. However, several aspects of this variety of neutropenia are unknown, including the duration, kinetic mechanism, and outcomes. METHODS: Using 10 years of multihospital records, we studied SGA neonates who, during the first week after birth, had neutrophil counts <1000/μL. RESULTS: This degree of neutropenia was more common in SGA neonates (6%, 207/3650) than in non-SGA matched controls (1%, 46/3650; P < ...
November 2015: Pediatrics
https://www.readbyqxmd.com/read/26298799/-ipilimumab-induced-colitis-a-new-challenge-for-gastroenterologists
#6
Francisco Mesonero, Antonio López-Sanromán, Ainhoa Madariaga, Ainara Soria
Many drugs can produce enterocolitis and they should always be included in the differential diagnosis of this clinical picture. Entities such as antibiotic-associated colitis and neutropenic colitis have been known for some time and recently a new type of drug-induced colitis has emerged due to monoclonal antibodies. Ipimumab is a humanized monoclonal antibody against the CTLA4 molecule that is involved in the maturation and regulation of T lymphocyte activation. This drug causes immune activation and has an immune-mediated antitumor effect with excellent results in tumours such as melanoma...
March 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/26281844/a-multidisciplinary-approach-to-perianal-and-intra-abdominal-infections-in-the-neutropenic-cancer-patient
#7
REVIEW
Patrick S Sullivan, Courtney Moreno
The chemotherapeutic treatment of both hematologic and solid organ malignancies has increased in recent decades, resulting in increased neutropenia-related perianal and intra-abdominal infections. Nearly 30% of neutropenia-related infections arise in the gastrointestinal tract. The management of these patients is often not straightforward, and the indications for and timing of surgical intervention continue to be unclear. The management strategy must take into account such factors as recent chemotherapy toxicity, stage and prognosis of the malignancy, performance status, comorbidities, degree of neutropenia, immunosuppression, thrombocytopenia, and corticosteroid use...
August 2015: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/26034404/noninfectious-colitides
#8
REVIEW
Mohammed Bayasi, Jose Quiogue
There are numerous etiologic and pathogenic mechanisms associated with colitis, ranging from infectious to noninfectious colitis. However, despite their different causes, their presentations are often similar making it difficult to formulate the correct diagnosis. This article describes the presentation, endoscopic and pathological findings of six different noninfectious colitides: diversion colitis, neutropenic enterocolitis, disinfectant colitis, corrosive colitis, nonsteroidal anti-inflammatory drug and salicylate-induced colitis, and toxic epidermal necrolysis...
June 2015: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/25813206/clinical-features-of-life-threatening-complications-following-autologous-stem-cell-transplantation-in-patients-with-lymphoma
#9
Lionel Kerhuel, Sandy Amorim, Elie Azoulay, Catherine Thiéblemont, Emmanuel Canet
Toxic effects of high dose therapy (HDT) combined with autologous stem cell transplantation (ASCT) can lead to life-threatening conditions that may require intensive care unit (ICU) admission. We conducted a retrospective observational study over a 10-year period of all patients admitted to the ICU within 3 months after HDT/ASCT for lymphoma. Among the 532 patients treated by HDT/ASCT at our hospital, 27 (5%) were admitted to the ICU. Infections accounted for 88% (n = 24) of diagnoses, in whom 50% were microbiologically documented...
2015: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/25612951/-fatal-neutropenic-enterocolitis-in-a-patient-with-castration-resistant-prostate-cancer-treated-with-first-line-chemotherapy
#10
Per Kongsted, Kiran Sheikh, Lene Sonne Mouritsen, Henriette Lindberg, Lisa Sengeløv
Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy. The pathogenesis is multi-factorial with mucosal injury and impaired mucosal defence as contributing factors. Histopathological findings are heterogeneous. Clinical presentation includes neutropenia, fever and abdominal pain. Treatment is not clearly defined. We present a fatal case of NE in a patient with prostate cancer treated with first-line chemotherapy, docetaxel 75 mg/m2 every three weeks and prednisolone 5 mg × 2 daily...
January 26, 2015: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/25578678/prognosis-of-neutropenic-patients-admitted-to-the-intensive-care-unit
#11
MULTICENTER STUDY
D Mokart, M Darmon, M Resche-Rigon, V Lemiale, F Pène, J Mayaux, A Rabbat, A Kouatchet, F Vincent, M Nyunga, F Bruneel, C Lebert, P Perez, A Renault, R Hamidfar, M Jourdain, A-P Meert, D Benoit, S Chevret, E Azoulay
PURPOSE: The prognosis of critically ill cancer patients has improved recently. Controversies remain as regard to the specific prognosis impact of neutropenia in critically ill cancer patients. The primary objective of this study was to assess hospital outcome of critically ill neutropenic cancer patients admitted into the ICU. The secondary objective was to assess risk factors for unfavorable outcome in this population of patients and specific impact of neutropenia. METHODS: We performed a post hoc analysis of a prospectively collected database...
February 2015: Intensive Care Medicine
https://www.readbyqxmd.com/read/25431154/how-to-treat-severe-infections-in-critically-ill-neutropenic-patients
#12
REVIEW
Lara Zafrani, Elie Azoulay
Severe infections in neutropenic patient often progress rapidly leading to life-threatening organ dysfunction requiring admission to the Intensive Care Unit. Management strategies include early adequate appropriate empirical antimicrobial, early admission to ICU to avoid any delay in the diagnostic and therapeutic management of organ dysfunction. This review discusses the main clinical situations encountered in critically ill neutropenic patients. Specific diagnostic and therapeutic approaches have been proposed for acute respiratory failure, shock, neutropenic enterocolitis, catheter-related infections, cellulitis and primary bacteriemia...
November 28, 2014: BMC Infectious Diseases
https://www.readbyqxmd.com/read/25380941/biosimilar-granulocyte-colony-stimulating-factor-is-effective-in-reducing-the-duration-of-neutropenia-after-autologous-peripheral-blood-stem-cell-transplantation
#13
M Cioch, D Jawniak, K Kotwica, M Wach, J Mańko, A Gorący, P Klimek, E Mazurkiewicz, P Jarosz, M Hus
BACKGROUND: Autologous peripheral blood stem cell transplantation (APBSCT) is the standard of therapy for patients with multiple myeloma and refractory Hodgkin's and non-Hodgkin's lymphomas. Granulocyte colony-stimulating factor (G-CSF) is widely used to accelerate hematopoietic recovery after transplantation and to reduce the morbidity and mortality associated with prolonged neutropenia. Biosimilar G-CSF is approved for the same indications as the originator G-CSF. This is one of the first reported uses of a biosimilar G-CSF for neutrophil recovery after APBSCT...
October 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/25076434/incidence-of-diarrhea-by-clostridium-difficile-in-hematologic-patients-and-hematopoietic-stem-cell-transplantation-patients-risk-factors-for-severe-forms-and-death
#14
Fernanda Spadão, Juliana Gerhardt, Thais Guimarães, Frederico Dulley, João Nóbrega de Almeida Junior, Marjorie Vieira Batista, Maria Aparecida Shikanai-Yasuda, Anna Sara Levin, Silvia Figueiredo Costa
We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with the severe form of the disease and death. The ELISA method (Ridascreen-Biopharm, Germany) for the detections of toxins A/B was used to identify C. difficile. A multivariate analysis was performed to evaluate potential factors associated with severe CDAD and death within 14 days after the diagnosis of CDAD, using multiple logistic regression...
July 2014: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/24960780/alithiasic-cholecystitis-treated-by-percutaneous-cholecystostomy-in-a-patient-with-severe-septic-shock-and-neutropenia
#15
N Simion
Acalculous cholecystitis is a relatively rare form of cholecystitis appearing in severely ill patients. We chose the case of a young patient under chemotherapy for myeloid leukaemia who developed a severe septic shock secondary to an alithiasic cholecystitis. Because of hemodynamic instability needing high-dose of vasoactive amines, percutaneous gallbladder drainage was done. After this intervention, the septic shock could be controlled, but a bleeding liver laceration was observed, fortunately without morbidity consequences...
2012: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/24792023/neutropenic-enterocolitis-affecting-the-transverse-colon-an-unusual-complication-of-chemotherapy
#16
Jason Ramsingh, Carsten Bolln, Robert Hodnett, Ahmed Al-Ani
A 66-year-old woman presented with a 1-day history of sudden onset of generalised abdominal pain associated with fever and vomiting. She was previously diagnosed with left breast cancer 2 months ago and completed a course of chemotherapy 1 week prior to presentation. She was clinically unwell with generalised tenderness in her abdomen. Blood investigations showed severe neutropenia. A CT scan was requested which reported a marked oedematous swelling of the transverse colon with features suggestive of a contained perforation...
May 2, 2014: BMJ Case Reports
https://www.readbyqxmd.com/read/24766347/atypical-presentation-of-acalculous-cholecystitis-with-marked-isolated-hyperbilirubinaemia-in-patients-treated-for-haematological-malignancies
#17
Marvin A H Berrevoets, John J Hermans, Geert J A Wanten, Walter J F M van der Velden
Four patients diagnosed with haematological malignancies developed an isolated hyperbilirubinaemia following cytarabine- and anthracycline-based chemotherapy. The clinical picture was consistent with acalculous cholecystitis, but ultrasonography did not show the typical gallbladder wall thickening. All patients suffered from severe mucositis with neutropenic enterocolitis. We hypothesise that damage of the mucosa of the gallbladder induced by chemotherapy results in hyperpermeability of the mucosal barrier with bile leakage and isolated hyperbilirubinaemia...
February 2015: European Journal of Haematology
https://www.readbyqxmd.com/read/24758620/case-records-of-the-massachusetts-general-hospital-case-13-2014-a-41-year-old-man-with-fever-and-abdominal-pain-after-stem-cell-transplantation
#18
Dimitrios P Kontoyiannis, Mahan Mathur, Yi-Bin Chen, Paul C Shellito, Julie Y Tse
Presentation of Case. Dr. Ricardo J. Cigarroa (Medicine): A 41-year-old man with B-cell acute lymphoblastic leukemia (ALL) underwent allogeneic peripheral-blood stem-cell transplantation, and afterward, fever and abdominal pain developed. The patient had been well until approximately 7 months..
April 24, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24743372/-neutropenic-enterocolitis-after-autologous-peripheral-blood-stem-cell-transplantation-in-non-hodgkin-s-lymphoma-a-case-report
#19
Daisuke Matsuoka, Masahiro Manabe, Junya Okita, Teruhito Takakuwa, Naonori Harada, Yasutaka Aoyama, Takeo Kumura, Tadanobu Ohta, Yoshio Furukawa, Atsuko Mugitani
Here we report a case of a 59-year-old man who developed neutropenic enterocolitis(NE)after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma in his second complete remission.Four days after transplantation, the patient suffered from diarrhea, abdominal pain, fever, and paralytic ileus.Abdominal computerized tomography scan revealed bowel wall thickening consistent with NE.Owing to his poor performance status, only medical management, including antibiotics and bowel rest, was administered, and the patient died 18 days after transplantation...
April 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/24716011/spontaneous-intestinal-perforation-an-atypical-presentation-of-neutropenic-enterocolitis-a-case-report
#20
Aylin Canbolat Ayhan, Cetin Timur, Ersin Bocu, Neslihan Gulcin
Background. Neutropenic enterocolitis is one of the most common gastrointestinal complications seen in patients who are receiving chemotherapy for leukemia. Severe neutropenia is the main underlying factor of this pathology. It is characterized by fever and abdominal pain. Case Presentation. Herein, we report a case of neutropenic enterocolitis which presented with intestinal perforation in an afebrile patient who was diagnosed with acute lymphoblastic leukemia and was receiving induction chemotherapy. Conclusion...
2014: Case Reports in Hematology
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