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Topical analgesics

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https://www.readbyqxmd.com/read/29775149/added-value-of-multiple-versus-single-sessions-of-repetitive-transcranial-magnetic-stimulation-in-predicting-motor-cortex-stimulation-efficacy-for-refractory-neuropathic-pain
#1
Benjamin Pommier, Charles Quesada, Camille Fauchon, Christophe Nuti, François Vassal, Roland Peyron
OBJECTIVE Selection criteria for offering patients motor cortex stimulation (MCS) for refractory neuropathic pain are a critical topic of research. A single session of repetitive transcranial magnetic stimulation (rTMS) has been advocated for selecting MCS candidates, but it has a low negative predictive value. Here the authors investigated whether multiple rTMS sessions would more accurately predict MCS efficacy. METHODS Patients included in this longitudinal study could access MCS after at least four rTMS sessions performed 3-4 weeks apart...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29765245/the-epidemiology-of-outpatient-pain-treatment-in-pediatrics
#2
Stacy Baldridge, Laura Wallace, Aditi Kadakia
Background: There is limited real-world, population-level data on the prevalence and treatment of pain in children. An understanding of pediatric pain conditions and its management can help inform provider education, treatment guidelines, and design of pediatric pain studies. Therefore, in this study, we aimed to describe the prevalence of conditions associated with acute and chronic pain in pediatric patients and to characterize pediatric pain treatment with nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 (COX-2) inhibitors, opioids (immediate release or extended release), antidepressants, topical analgesics, anticonvulsants, and other therapies based on a large, real-world sample...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29736742/a-double-blind-randomised-trial-of-a-polyphenolic-rich-nail-bed-balm-for-chemotherapy-induced-onycholysis-the-uk-polybalm-study
#3
Robert Thomas, Madeleine Williams, Michael Cauchi, Saul Berkovitz, Sarah A Smith
PURPOSE: Nail damage is common amongst patients receiving chemotherapy causing disfigurement and pain. This investigation evaluated whether a topical balm containing steam-extracted, bioactive polyphenolic-rich herbal oils blended with organic waxes could protect the nails via their reported anti-inflammatory, analgesic, anti-oxidant and anti-microbial properties. METHODS: 60 patients (23M, 37F) were randomised to apply (2-3/day) either the plant balm (PB) or a petroleum control (PC) to their nail beds...
May 7, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29729778/cancer-related-neuropathic-pain-review-and-selective-topics
#4
REVIEW
Mellar P Davis
Neuropathic pain is the result of neuroplastic and neuroinflammatory changes from trauma or diseases that damage the somatosensory system. Cancer-related neuropathic pain is caused by treatment, cancer, or paraneoplastic reactions to cancer. Approximately 30% of patients with cancer have neuropathic pain, mostly mixed nociceptive and neuropathic pain. History, physical examination, quantitative sensory testing, skin punch biopsies, and functional MRIs help to divide pain into phenotypes that may facilitate analgesic choices...
June 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29721732/a-prospective-randomized-double-blind-study-of-pain-control-by-topical-calcium-channel-blockers-versus-placebo-after-milligan-morgan-hemorrhoidectomy
#5
Sunandan Yadav, Radha Govind Khandelwal, Prabha Om, K Ravindra, Kanhaiya Lal Choudhary
INTRODUCTION: Post-hemorrhoidectomy pain is significantly associated with a hypertonicity of the internal anal sphincter. We evaluated the effects of topical diltiazem, a calcium channel blocker, in reducing pain after hemorrhoidectomy. Purpose of our study was to determine difference in extent of pain control by application of topical calcium channel blocker (diltiazem 2%) versus placebo ointment. METHODS: This was a prospective randomized double-blind clinical study conducted at Sawai Man Singh Hospital, Jaipur, from May 2016 to May 2017...
May 2, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29713640/the-use-of-ropivacaine-in-therapeutic-treatment-of-oral-aphthosis
#6
Giulio Gasparini, Gianmarco Saponaro, Daniela Gasparini, Enrico Foresta, Camillo Azzuni, Alessia Adduci, Roberto Boniello, Alessandro Moro, Paolo De Angelis, Francesco Di Nardo, Giuseppe Damato, Piero Doneddu, Mattia Todaro, Umberto Garagiola, Sando Pelo
The use of anaesthetic drugs in the treatment of oral aphthosis is one of the pharmaceutical possibilities that a doctor can use for the most painful forms. Normally, Lidocaine or Diclofenac is used to treat this disease, but they can be used for a very limited time and so they are of little practical use. In this study, the authors have used Ropivacaine whose pharmaceutical kinetics allows the analgesic effect to be active for 60 to 90 minutes. In our research, we compared 8 groups of patients who have been given 3 principal pharmaceutical products: one group was given an anaesthetic drug, one had a topical medication administered which is often used for the treatment of aphthous lesions, and the last group was given a multivitamin...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29709684/the-re-emerging-of-orf-virus-infection-a-call-for-surveillance-vaccination-and-effective-control-measures
#7
REVIEW
Jamilu Abubakar Bala, Krishnan Nair Balakrishnan, Ashwaq Ahmed Abdullah, Ramlan Mohamed, Abd Wahid Haron, Faez Firdaus Abdullah Jesse, Mustapha M Noordin, Mohd Lila Mohd-Azmi
Orf disease is known to be enzootic among small ruminants in Asia, Africa, and some other parts of the world. The disease caused by orf virus is highly contagious among small ruminant species. Unfortunately, it has been neglected for decades because of the general belief that it only causes a self-limiting disease. On the other hand, in the past it has been reported to cause huge cumulative financial losses in livestock farming. Orf disease is characterized by localized proliferative and persistent skin nodule lesions that can be classified into three forms: generalized, labial and mammary or genitals...
April 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29698108/capsaicin-based-analgesic-balm-attenuates-the-skeletal-muscle-metaboreflex-in-healthy-humans
#8
Lauro C Vianna, Igor A Fernandes, Thales C Barbosa, André L Teixeira, Antonio Claudio Lucas da Nóbrega
The exercise pressor reflex (EPR) is comprised from group III and IV skeletal muscle afferents and is one of the principal mediators of the cardiovascular response to exercise. In animals, capsaicin-based analgesic balm (CAP) attenuates the pressor response to muscle contraction, indicating the transient receptor potential vanilloid 1 (TRPv1) receptor (localized on the group IV afferent neuron) as an important mediator of the EPR. However, whether these findings can be extrapolated to humans remain unknown...
April 26, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29698074/use-of-a-compounded-poloxamer-407-antibiotic-topical-therapy-as-part-of-the-successful-management-of-chronic-ulcerative-dermatitis-in-a-congo-african-grey-parrot-psittacus-erithacus
#9
Anthony A Pilny
A 23-year-old, 425-g male African grey parrot ( Psittacus erithacus) was evaluated for chronic ulcerative dermatitis of the axillary regions under both wings. Initial swab cultures of the sites had revealed a coagulase-positive methicillin-resistant Staphylococcus aureas (MRSA) with marked antibiotic resistance. A second swab culture obtained 8 weeks after the initial culture showed heavy growth of a coagulase-positive Staphylococcus species, which could not be speciated, but showed the same sensitivity as the previous culture...
March 2018: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29684910/forensic-applications-of-supercritical-fluid-chromatography-mass-spectrometry
#10
REVIEW
Volodymyr Pauk, Karel Lemr
Achievements of supercritical fluid chromatography with mass spectrometric detection made in the field of forensic science during the last decade are reviewed. The main topics include analysis of traditional drugs of abuse (e.g. cannabis, methamphetamine) as well as new psychoactive substances (synthetic cannabinoids, cathinones and phenethylamines), doping agents (anabolic steroids, stimulants, diuretics, analgesics etc.) and chemical warfare agents. Control of food authenticity, detection of adulteration and identification of toxic substances in food are also pointed out...
April 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29664447/comparison-table-some-oral-topical-opioid-analgesics
#11
(no author information available yet)
No abstract text is available yet for this article.
April 9, 2018: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/29659054/tuning-in-c-nociceptors-to-reveal-mechanisms-in-chronic-neuropathic-pain
#12
Robin Jonas, Barbara Namer, Lenka Stockinger, Kim Chisholm, Mark Schnakenberg, Gunther Landmann, Mateusz Kucharczyk, Christoph Konrad, Roland Schmidt, Richard Carr, Stephen McMahon, Martin Schmelz, Roman Rukwied
OBJECTIVE: Develop and validate a low-intensity sinusoidal electrical stimulation paradigm to preferentially activate C-fibers in human skin. METHODS: Sinusoidal transcutaneous stimulation (4 Hz) was assessed psychophysically in healthy volunteers (n=14) and neuropathic pain patients (n=9). Pursuing laser Doppler imaging and single nociceptor recordings in vivo in humans (microneurography) and pigs confirmed the activation of "silent" C-nociceptors. Synchronized C-fiber compound action potentials were evoked in isolated human nerve fascicles in vitro...
April 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29609700/use-of-topical-morphine-to-relieve-painful-pressure-ulcers
#13
Sandra L Discala, Danny Basri, Christine M Vartan, Michael A Silverman
INTRODUCTION: Topical morphine is a potential treatment option for painful pressure ulcers in hospice and palliative care patients who favor avoidance of systemic opioid therapy. CASE: A 65-year-old male African-American veteran with a painful stage 3 sacral pressure injury was hesitant to take systemic opioids to control his pain, as he wished to stay alert for family and friends. Topical morphine was initiated, and within 24 hours the patient reported a significant reduction in pain on the numeric rating scale...
April 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29596157/machine-learned-analysis-of-the-association-of-next-generation-sequencing-based-human-trpv1-and-trpa1-genotypes-with-the-sensitivity-to-heat-stimuli-and-topically-applied-capsaicin
#14
Dario Kringel, Gerd Geisslinger, Eduard Resch, Bruno G Oertel, Michael C Thrun, Sarah Heinemann, Jörn Lötsch
Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. However, TRPA1 channels can heterodimerize with TRPV1 channels and carry genetic variants reported to modulate heat pain sensitivity. To address the role of these candidate genes in capsaicin induced hypersensitization to heat, pain thresholds acquired before and after topical application of capsaicin and TRPA1/TRPV1 exomic sequences derived by next-generation sequencing were assessed in n = 75 healthy volunteers and the genetic information comprised 278 loci...
March 27, 2018: Pain
https://www.readbyqxmd.com/read/29574683/topical-application-of-corticosteroids-to-tracheal-tubes-to-prevent-postoperative-sore-throat-in-adults-undergoing-tracheal-intubation-a-systematic-review-and-meta-analysis
#15
REVIEW
A Kuriyama, H Maeda, R Sun, M Aga
Postoperative sore throat negatively affects patient satisfaction and recovery. Numerous randomised trials have tested the efficacy of corticosteroids applied to tracheal tubes to prevent postoperative sore throat. We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Wanfang Database, and the China Academic Journal Network Publishing Database from inception to 7 December 2017. We included randomised controlled trials that assessed the efficacy and safety of corticosteroids applied to tracheal tubes, compared either with non-analgesic controls and analgesic agents, in adults undergoing elective surgery under general anaesthesia...
March 25, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29567597/a-randomised-field-study-evaluating-the-effectiveness-of-buccal-meloxicam-and-topical-local-anaesthetic-formulations-administered-singly-or-in-combination-at-improving-welfare-of-female-merino-lambs-undergoing-surgical-mulesing-and-hot-knife-tail-docking
#16
Alison Holdhus Small, Danila Marini, Tim Dyall, David Paull, Caroline Lee
This study was a field-based behavioural assessment of the pain responses to surgical mulesing modulated by a buccal formulation of meloxicam (Buccalgesic) and a topical local anaesthetic wound dressing (Tri-Solfen). 20 lambs were randomly allocated to each of: 1) Placebo and sham handled (Sham); 2) Placebo and mulesing (Mules); 3) Buccalgesic and mulesing (Mules+B); 4) Tri-Solfen and mulesing (Mules+T); 5) Placebo, Tri-Solfen and mulesing (Mules+T+P); 6) Buccalgesic, Tri-Solfen and mulesing (Mules+T+B). Lamb behaviour was observed by scan sampling every 15 min for 6 h post mulesing then for 1...
March 8, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29564635/-pain-therapy-for-premature-babies-and-neonates
#17
M Richter, B Seipolt
Pain is a central topic on neonatal intensive care units (NICU). Acute as well as prolonged (continuous and chronic) pain frequently occurs. Due to a lack of validated physiological measurement instruments for pain (e. g. saliva cortisol, skin conductance and heart rate variability) pain in neonatology can only be assessed by external observation through the bedside team with pain scores using a regular, standardized procedure. During this very vulnerable period pain and medications (analgesics/sedatives) can negatively influence the brain development of premature babies and neonates...
March 21, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29562618/transdermal-and-topical-drug-administration-in-the-treatment-of-pain
#18
REVIEW
Wojciech Leppert, Malgorzata Malec-Milewska, Renata Zajaczkowska, Jerzy Wordliczek
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients' age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms...
March 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29556559/administration-order-of-midazolam-fentanyl-for-moderate-dental-sedation
#19
Douglas Lobb, Alix Clarke, Hollis Lai
Background: The purpose of this study is to investigate the effects of administration order when a sedative drug (midazolam) and an opioid analgesic drug (fentanyl) is applied for moderate intravenous (IV) sedation in dentistry. Methods: A retrospective chart review was conducted in one dental clinic during its transition from a midazolam-first to a fentanyl-first protocol for dental procedures requiring moderate IV sedation. Physiological parameters, drug administration times, patient recovery times, drug dosages, and patient recall and satisfaction were investigated for differences...
February 2018: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29556555/randomized-controlled-trial-to-compare-oral-analgesic-requirements-and-patient-satisfaction-in-using-oral-non-steroidal-anti-inflammatory-drugs-versus-benzydamine-hydrochloride-oral-rinses-after-mandibular-third-molar-extraction-a-pilot-study
#20
Devalina Goswami, Gaurav Jain, Mangesh Mohod, Dalim Kumar Baidya, Ongkila Bhutia, Ajoy Roychoudhury
Background: Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling postoperative pain following third molar extraction. Methods: A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol...
February 2018: Journal of Dental Anesthesia and Pain Medicine
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