keyword
MENU ▼
Read by QxMD icon Read
search

Topical analgesics

keyword
https://www.readbyqxmd.com/read/28729062/pharmacological-activation-of-ampk-inhibits-incision-evoked-mechanical-hypersensitivity-and-the-development-of-hyperalgesic-priming-in-mice
#1
Michael D Burton, Dipti V Tillu, Khadijah Mazhar, Galo L Mejia, Marina N Asiedu, Kufreobong Inyang, Travis Hughes, Bo Lian, Gregory Dussor, Theodore J Price
New therapeutics to manage post-surgical pain are needed to mitigate the liabilities of opioid and other analgesics. Our previous work shows that key modulators of excitability in peripheral nociceptors, such as extracellular signal-regulated kinases (ERK) are inhibited by activation of adenosine monophosphate activated protein kinase (AMPK). We hypothesized that AMPK activation would attenuate acute incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming caused by surgery in mice...
July 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28727706/opioids-for-ocular-pain-a-narrative-review
#2
Vinicius Bp Pereira, Renato Garcia, Andre Am Torricelli, Samir J Bechara
BACKGROUND: Refractive surgery is a common procedure, but may be associated with severe post-operative pain. OBJECTIVES: To describe studies addressing the use of opioids for control of pain after ocular surgery, with an emphasis on refractive surgery. STUDY DESIGN: This is a narrative review of relevant articles on the physiology of corneal pain and the use of opioids for its treatment after surgery. SETTING: Single tertiary center...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28724494/pharmacokinetics-of-a-novel-transdermal-fentanyl-solution-in-rhesus-macaques-macaca-mulatta
#3
Gregory W Salyards, Marie-Josee Lemoy, Heather K Knych, Ashley E Hill, Kari L Christe
Rhesus macaques (Macaca mulatta) are the most commonly used NHP biomedical model and experience both research and clinical procedures requiring analgesia. Opioids are a mainstay of analgesic therapy. A novel, transdermal fentanyl solution (TFS) has been developed as a long-acting, single-administration topical opioid and was reported to provide at least 4 d of effective plasma concentrations in beagles (Canis familiaris). To evaluate the pharmacokinetic profile of TFS in healthy adult rhesus macaques, we used a 2-period, 2-treatment crossover study of a single topical administration of 1...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28714189/esthesiometric-evaluation-of-corneal-analgesia-after-topical-application-of-1-morphine-sulfate-in-normal-horses
#4
Emma Gordon, Christy Sandquist, Christopher K Cebra, Jerry Heidel, Keith Poulsen, John W Schlipf
OBJECTIVE: To evaluate whether topical ocular application of 1% morphine sulfate would change corneal sensitivity and to identify the duration of action. ANIMAL STUDIED: Eight healthy adult horses. PROCEDURE: Corneal touch threshold (CTT) was measured in the center of one randomly selected eye of each horse by Cochet-Bonnet esthesiometer (Luneau Cochet-Bonnet Esthesiometer; Western Ophthalmics, Lynnwood, WA, USA). Immediately following baseline CTT measurement, 0...
July 17, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28712268/the-anti-inflammatory-and-antioxidant-properties-of-1-2-decanediol-and-willow-bark-extract-in-lipopolysaccharide-stimulated-keratinocytes
#5
Roberta DI Caprio, Giuseppe Monfrecola, Anna Balato, Nicola Balato, Franco Gasparri, Raffaella Micillo, Serena Lembo
BACKGROUND: The 1,2-decanediol (S-Mal) is an organic compound belonging to the 1,2- alkanediol family, with two hydroxyl groups located on the first and second carbon of the alkane chain, probably responsible for the enhanced anti-bacterial efficacy. The willow bark total extract (W-Mal) has been used since thousands of years as an herbal remedy for its antipyretic, analgesic, anti-inflammatory and anti-microbial activities. S-Mal is used in cosmetic preparations, whether W- Mal can be topically or systemically administered...
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28696784/the-role-of-tramadol-in-pain-management-in-latin-america-a-report-by-the-change-pain-latin-america-advisory-panel
#6
Joäo Batista Santos Garcia, Osvandré Lech, Durval Campos Kraychete, María Antonieta Rico, John Jairo Hernández-Castro, Frantz Colimon, Carlos Guerrero, Manuel Sempértegui Gallegos, Argelia Lara-Solares, José Alberto Flores Cantisani, César Amescua-Garcia, María Del Rocío Guillén Núñez, María Del Rosario Berenguel Cook, Aziza Jreige Iskandar, Patricia Bonilla Sierra
OBJECTIVE: Change Pain Latin America (CPLA) was created to enhance chronic pain understanding and develop pain management improving strategies in this region. During its 7(th) meeting (August 2016), the main objective was to discuss tramadol's role in treating pain in Latin America. Furthermore, potential pain management consequences were considered, if tramadol was to become more stringently controlled. METHODS: Key topics discussed were: main indications for prescribing tramadol, its pharmacological characteristics, safety and tolerability, effects of restrictions on its availability and use, and consequent impact on the pain care quality...
July 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28652650/role-of-non-steroidal-anti-inflammatory-drugs-on-intestinal-permeability-and-nonalcoholic-fatty-liver-disease
#7
REVIEW
Erika Utzeri, Paolo Usai
The use of non-steroidal anti-inflammatory drugs (NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28645220/comparison-of-emla-cream-and-topical-lidocaine-tape-for-pain-relief-of-v-beam-laser-treatment
#8
Masaru Horikiri, Kazuki Ueda, Takao Sakaba
The authors compared the analgesic effects of two topical applications; Emla(®) cream (Sato Pharmaceutical Co. Ltd., Tokyo, Japan) and 60% lidocaine tape (Penles(®) tape; Maruho, Osaka, Japan). The authors examined 20 outpatients with capillary malformations. Emla(®) cream or Penles(®) tape was applied 1 h before laser irradiation using V-Beam. After V-Beam irradiation, pain intensity was measured using Pain Vision(®) (NIPRO, Osaka, Japan), while subjective pain was converted into numerical values using the VAS system...
June 23, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28614189/a-dose-response-study-of-topical-allyl-isothiocyanate-mustard-oil-as-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation
#9
H H Andersen, S Lo Vecchio, P Gazerani, L Arendt-Nielsen
Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl-isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, 90%) and vehicle (paraffin) were applied for 5 min to 3x3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28602044/the-dynamic-interaction-between-pain-and-opioid-misuse
#10
REVIEW
Adrianne R Wilson-Poe, Jose A Morón
In 2014, drug overdose surpassed automobile accidents as the number one cause of accidental death for the first time in the history of the United States. The overdose epidemic is largely driven by opioids, and genuine prescription opioid analgesics play the biggest role in this phenomenon. Despite advancements in abuse deterrent formulations, prescription drug monitoring programmes and clinical assessments for the detection of abuse potential, drug overdoses continue to escalate. The Center for Disease Control has recently issued new guidelines for opioid prescription, yet even these recommendations have their shortcomings...
June 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28593835/pharmacokinetics-of-a-novel-transdermal-fentanyl-solution-in-rhesus-macaques-macaca-mulatta
#11
Gregory W Salyards, Marie-Josee Lemoy, Heather K Knych, Ashley E Hill, Kari L Christe
Rhesus macaques (Macaca mulatta) are the most commonly used NHP biomedical model and experience both research andclinical procedures requiring analgesia. Opioids are a mainstay of analgesic therapy. A novel, transdermal fentanyl solution(TFS) has been developed as a long-acting, single-administration topical opioid and was reported to provide at least 4 d ofeffective plasma concentrations in beagles (Canis familiaris). To evaluate the pharmacokinetic profile of TFS in healthy adultrhesus macaques, we used a 2-period, 2-treatment crossover study of a single topical administration of 1...
June 7, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28592563/the-effects-of-treatment-failure-generalize-across-different-routes-of-drug-administration
#12
Matthias Zunhammer, Markus Ploner, Charlotte Engelbrecht, Johanna Bock, Simon S Kessner, Ulrike Bingel
Failure of medical treatments can hamper responses to subsequent treatments. It has been suggested that changing the route of drug administration could reduce such negative carry-over effects, but direct evidence for this approach is lacking. We therefore investigated in 211 healthy volunteers whether changes in drug administration route reduce such carry-over effects. A positive or negative treatment history with topical analgesic treatments was induced experimentally in a mock clinical trial setting. Subsequently, a different inert drug was introduced via the same (topical) or another (oral) route of administration and its analgesic efficacy was tested...
June 7, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28583486/ototoxicity-associated-with-topical-administration-of-diclofenac-sodium-as-an-otic-drop-an-experimental-animal-study
#13
Engin Acioglu, Ozgur Yigit, Firat Onur, Ahmet Atas, Ela Araz Server, Eyup Kara
OBJECTIVES: The aim of the study is to evaluate the ototoxicity of topical diclofenac sodium in comparison to positive and negative controls prior to the investigation of analgesic and anti-inflammatory efficacy of the agent in otic administration. METHODS: Twenty four ears of 12 guinea pigs were included in the study. Wide myringotomy was performed on all tympanic membranes under general anesthesia and auditory brainstem responses (ABR) were evaluated. The subjects were separated into four groups, two groups received diclofenac sodium at low and high doses, positive controls received gentamicin and negative controls received isotonic sodium chloride topically for 14 days and ABRs were reevaluated...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28579775/capsaicin-loaded-nanolipoidal-carriers-for-topical-application-design-characterization-and-in-vitro-in-vivo-evaluation
#14
Xia-Rong Wang, Si-Qian Gao, Xiao-Qian Niu, Long-Jian Li, Xiao-Ying Ying, Zhong-Jie Hu, Jian-Qing Gao
Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and later optimized by the Box-Behnken design. The physicochemical characterizations, morphology, and encapsulation of the capsaicin-loaded NLCs were subsequently confirmed...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28567799/cox-2-selective-inhibitors-celecoxib-and-deracoxib-modulate-transient-receptor-potential-vanilloid-3-channels
#15
Stefan Spyra, Anne Meisner, Michael Schaefer, Kerstin Hill
BACKGROUND AND PURPOSE: The transient receptor potential vanilloid 3 (TRPV3) channel is a heat-sensitive ion channel, which is predominantly expressed in keratinocytes. TRPV3 channels are involved in numerous physiological and pathophysiological processes within the skin, including cutaneous nociception, temperature sensation and development of itch. The role of TRPV3 channels in such processes is poorly understood; therefore, the establishment of selective modulators of TRPV3 channels is highly desirable...
May 31, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28546768/effectiveness-of-various-formulations-of-local-anesthetics-and-additives-for-topical-anesthesia-a-prospective-randomized-double-blind-placebo-controlled-study
#16
Christian Weilbach, Christian Hoppe, Matthias Karst, Michael Winterhalter, Konstantinos Raymondos, Arthur Schultz, Niels Rahe-Meyer
BACKGROUND: Topical anesthesia is used to control pain associated with many procedures in medicine. Today, the product most commonly applied for topical anesthesia in Germany is EMLA(®) (lidocaine/prilocaine). However, since prilocaine is a methemoglobin-inducing agent, there are limitations to its use, especially in neonates and infants. The aim of this study was to evaluate the effect of prilocaine and lidocaine as well as propylene glycol, a penetration enhancer, and trometamol, a buffer substance, in anesthetic creams...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28535895/inadequate-pain-relief-among-patients-with-primary-knee-osteoarthritis
#17
Pedro A Laires, Jorge Laíns, Luís C Miranda, Rui Cernadas, Srini Rajagopalan, Stephanie D Taylor, José C Silva
BACKGROUND: Despite the widespread treatments for osteoarthritis (OA), data on treatment patterns, adequacy of pain relief, and quality of life are limited. The prospective multinational Survey of Osteoarthritis Real World Therapies (SORT) was designed to investigate these aspects. OBJECTIVES: To analyze the characteristics and the patient reported outcomes of the Portuguese dataset of SORT at the start of observation. METHODS: Patients ≥50 years with primary knee OA who were receiving oral or topical analgesics were eligible...
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28527126/polycaprolactone-based-nanoparticles-loaded-with-indomethacin-for-anti-inflammatory-therapy-from-preparation-to-ex-vivo-study
#18
Waisudin Badri, Karim Miladi, Sophie Robin, Céline Viennet, Qand Agha Nazari, Géraldine Agusti, Hatem Fessi, Abdelhamid Elaissari
PURPOSE: This work focused on the preparation of polycaprolactone based nanoparticles containing indomethacin to provide topical analgesic and anti-inflammatory effect for symptomatic treatment of inflammatory diseases. Indomethacin loaded nanoparticles are prepared for topical application to decrease indomethacin side effects and administration frequency. Oppositely to already reported works, in this research non-invasive method has been used for the enhancement of indomethacin dermal drug penetration...
May 19, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28516471/topical-non-steroidal-anti-inflammatory-drugs-for-analgesia-in-traumatic-corneal-abrasions
#19
REVIEW
Abel Wakai, John G Lawrenson, Annali L Lawrenson, Yongjun Wang, Michael D Brown, Michael Quirke, Omar Ghandour, Ryan McCormick, Cathal D Walsh, Ahmed Amayem, Eddy Lang, Nick Harrison
BACKGROUND: Traumatic corneal abrasions are relatively common and there is a lack of consensus about analgesia in their management. It is therefore important to document the clinical efficacy and safety profile of topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) in the management of traumatic corneal abrasions. OBJECTIVES: To identify and evaluate all randomised controlled trials (RCTs) comparing the use of topical NSAIDs with placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions (including corneal abrasions arising from foreign body removal), to reduce pain, and its effects on healing time...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28508561/diclofenac-for-pain-associated-with-intravitreal-injections-a-prospective-randomized-placebo-controlled-study
#20
Olga E Makri, Foteini N Tsapardoni, Dionisios D Pagoulatos, Nikolaos Pharmakakis, Constantine D Georgakopoulos
IMPORTANCE: Intravitreal injections (IVI) are often associated with pain. BACKGROUND: To evaluate the analgesic effect of diclofenac in patients undergoing IVI. DESIGN: Single-centre, prospective, randomized, triple-arm, placebo-controlled, interventional study in the University Hospital of Patras. PARTICIPANTS: Seventy-four patients. METHODS: Group 1 (n = 25) received topical diclofenac 45 minutes before IVI, Group 2 (n = 25) received oral diclofenac 4 hours before IVI and topical diclofenac while Group 3 (n = 24) received placebo before IVI...
May 15, 2017: Clinical & Experimental Ophthalmology
keyword
keyword
65574
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"