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Trigger point injections

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https://www.readbyqxmd.com/read/27909097/induction-of-migraine-like-photophobic-behavior-in-mice-by-both-peripheral-and-central-cgrp-mechanisms
#1
Bianca N Mason, Eric A Kaiser, Adisa Kuburas, Maria-Cristina M Loomis, John A Latham, Leon F Garcia-Martinez, Andrew F Russo
: The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine. While migraine can be treated using CGRP antagonists that act peripherally, the relevant sites of CGRP action remain unknown. To address the role of CGRP both within and outside the central nervous system, we used CGRP-induced light aversive behavior in mice as a measure of migraine-associated photophobia. Peripheral (intraperitoneal, IP) injection of CGRP resulted in light aversive behavior in wild-type CD1 mice similar to aversion previously seen following central (intracerebroventricular, ICV) injection...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27898454/transvaginal-pelvic-floor-muscle-injection-technique-a-cadaver-study
#2
Priyanka Gupta, Michael Ehlert, Larry T Sirls, Kenneth Peters
INTRODUCTION: Women with pelvic floor dysfunction can have tender areas on vaginal examination, which can be treated with trigger-point injections. There are no publications to evaluate the accuracy of pelvic floor muscle injections. METHODS: Trigger-point injections were performed on 2 fresh cadaveric pelvises using a curved nasal cannula guide and 7-in spinal needle. This was performed using our standard template of 2 sets of injections at the 1-, 3-, and 5-o'clock positions distally and proximally...
November 28, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27831558/ripk1-protects-from-tnf-%C3%AE-mediated-liver-damage-during-hepatitis
#3
Aveline Filliol, Claire Piquet-Pellorce, Jacques Le Seyec, Muhammad Farooq, Valentine Genet, Catherine Lucas-Clerc, John Bertin, Peter J Gough, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu Jm Bertrand, Michel Samson
Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function. However, the precise molecular mechanisms of hepatocyte cell death, the role of the cytokines of hepatic microenvironment and the involvement of intracellular kinases, remain unclear. Tumor necrosis factor alpha (TNF-α) is a key cytokine involved in cell death or survival pathways and the role of RIPK1 has been associated to the TNF-α-dependent signaling pathway...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27825520/versatility-of-a-localized-surface-plasmon-resonance-based-gold-nanoparticle-alloyed-quantum-dot-nanobiosensor-for-immunofluorescence-detection-of-viruses
#4
Kenshin Takemura, Oluwasesan Adegoke, Naoto Takahashi, Tatsuya Kato, Tian-Cheng Li, Noritoshi Kitamoto, Tomoyuki Tanaka, Tetsuro Suzuki, Enoch Y Park
Flu infection, caused by the influenza virus, constitutes a serious threat to human lives worldwide. A rapid, sensitive and specific diagnosis is urgently needed for point-of-care treatment and to control the rapid spread of this disease. In this study, an ultrasensitive, rapid and specific localized surface plasmon resonance (LSPR)-induced immunofluorescence nanobiosensor has been developed for the influenza virus based on a gold nanoparticle (AuNP)-induced quantum dot (QD) fluorescence signal. Alloyed quaternary CdSeTeS QDs were synthesized via the hot-injection organometallic route and were subsequently capped with l-cysteine via a ligand exchange reaction...
October 20, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27812322/tamoxifen-in-the-mouse-brain-implications-for-fate-mapping-studies-using-the-tamoxifen-inducible-cre-loxp-system
#5
Martin Valny, Pavel Honsa, Denisa Kirdajova, Zdenek Kamenik, Miroslava Anderova
The tamoxifen-inducible Cre-loxP system is widely used to overcome gene targeting pre-adult lethality, to modify a specific cell population at desired time-points, and to visualize and trace cells in fate-mapping studies. In this study we focused on tamoxifen degradation kinetics, because for all genetic fate-mapping studies, the period during which tamoxifen or its metabolites remain active in the CNS, is essential. Additionally, we aimed to define the tamoxifen administration scheme, enabling the maximal recombination rate together with minimal animal mortality...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27779493/participation-of-hippocampal-nitric-oxide-synthase-and-soluble-guanylate-cyclase-in-the-modulation-of-behavioral-responses-elicited-by-the-rat-forced-swimming-test
#6
Amanda J Sales, Vinícius A Hiroaki-Sato, Sâmia R L Joca
Systemic or hippocampal administration of nitric oxide (NO) synthase inhibitors induces antidepressant-like effects in animals, implicating increased hippocampal levels of NO in the neurobiology of depression. However, the role played by different NO synthase in this process has not been clearly defined. As stress is able to induce neuroinflammatory mechanisms and trigger the expression of inducible nitric oxide synthase (iNOS) in the brain, as well as upregulate neuronal nitric oxide synthase (nNOS) activity, the aim of the present study was to investigate the possible differential contribution of hippocampal iNOS and nNOS in the modulation of the consequences of stress elicited by the forced swimming test...
October 24, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27778485/in-vivo-biocompatibility-of-p-hpmam-lac-peg-hydrogels-hybridized-with-hyaluronan
#7
Maria Giovanna Sabbieti, Alessandra Dubbini, Fulvio Laus, Emanuele Paggi, Andrea Marchegiani, Melania Capitani, Luigi Marchetti, Fabrizio Dini, Tina Vermonden, Piera Di Martino, Dimitrios Agas, Roberta Censi
The present study reports on the biocompatibility in vivo after intramuscular and subcutaneous administration in Balb/c mice of vinyl sulphone bearing p(HPMAm-lac1-2)-PEG-p(HPMAm-lac1-2)/thiolated hyaluronic acid hydrogels, designed as novel injectable biomaterials for potential application in the fields of tissue engineering and regenerative medicine. Ultrasonography, used as a method to study hydrogel gelation and residence time in vivo, showed that, upon injection, the biomaterial efficiently formed a hydrogel by simultaneous thermal gelation and Michael Addition cross-linking forming a viscoelastic spherical depot at the injection site...
October 24, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27752210/a-comparative-study-of-trigger-point-therapy-with-local-anaesthetic-0-5%C3%A2-bupivacaine-versus-combined-trigger-point-injection-therapy-and-levosulpiride-in-the-management-of-myofascial-pain-syndrome-in-the-orofacial-region
#8
Pranav Gupta, Virendra Singh, Sujata Sethi, Arun Kumar
AIM: To compare the efficacy of combined local anesthetic injection with 0.5 % bupivacaine and levosulpiride versus local anesthetic injection alone on outcome measures including levels of pain intensity and depression in the management of myofascial pain syndrome in orofacial region. PATIENTS AND METHODS: This was a prospective, randomized, controlled and open-label comparative clinical study. Seventy-four patients diagnosed to have myofascial pain syndrome and fulfilling the inclusion criteria were enrolled for the study...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27738508/chronic-pelvic-pain-arising-from-dysfunctional-stabilizing-muscles-of-the-hip-joint-and-pelvis
#9
Dae Wook Lee, Chang Hun Lim, Jae Young Han, Woong Mo Kim
Chronic pelvic pain in women is a very annoying condition that is responsible for substantial suffering and medical expense. But dealing with this pain can be tough, because there are numerous possible causes for the pelvic pain such as urologic, gynecologic, gastrointestinal, neurologic, or musculoskeletal problems. Of these, musculoskeletal problem may be a primary cause of chronic pelvic pain in patients with a preceding trauma to the low back, pelvis, or lower extremities. Here, we report the case of a 54-year-old female patient with severe chronic pelvic pain after a transcutaneous electrical nerve stimulation (TENS) accident that was successfully managed with image-guided trigger point injections on several pelvic stabilizing muscles...
October 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27733171/persistent-neuroinflammation-and-cognitive-impairment-in-a-rat-model-of-acute-diisopropylfluorophosphate-intoxication
#10
Brenna M Flannery, Donald A Bruun, Douglas J Rowland, Christopher N Banks, Adam T Austin, David L Kukis, Yonggang Li, Byron D Ford, Daniel J Tancredi, Jill L Silverman, Simon R Cherry, Pamela J Lein
BACKGROUND: Acute intoxication with organophosphorus (OP) cholinesterase inhibitors can trigger convulsions that progress to life-threatening status epilepticus. Survivors face long-term morbidity including mild-to-severe decline in memory. It is posited that neuroinflammation plays a key role in the pathogenesis of OP-induced neuropsychiatric deficits. Rigorous testing of this hypothesis requires preclinical models that recapitulate relevant phenotypic outcomes. Here, we describe a rat model of acute intoxication with the OP diisopropylfluorophosphate (DFP) that exhibits persistent neuroinflammation and cognitive impairment...
October 12, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27732109/ischemia-reperfusion-injury-triggers-tnf%C3%AE-induced-necroptosis-in-rat-retina
#11
Cho Rong Kim, Jie Hyun Kim, Hae-Young Lopilly Park, Chan Kee Park
PURPOSE: A recent study revealed a novel form of cell death, termed necroptosis, or programmed necrosis. Previous research indicated that after ischemia-reperfusion (IR) injury to the retina, Tumor Necrosis Factor α (TNFα) is increased, which may activate necroptosis. This study observed macroglial cell activation, and in particular, astrocyte activation, after the release of TNFα and other necroptosis factors in the rat retina due to IR. MATERIALS AND METHODS: IR was induced in the retinas of adult male Sprague-Dawley rats by increasing the intraocular pressure to 160 mmHg and then allowing reperfusion...
October 12, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27731894/patterns-of-use-of-peripheral-nerve-blocks-and-trigger-point-injections-for-pediatric-headache-results-of-a-survey-of-the-american-headache-society-pediatric-and-adolescent-section
#12
Christina L Szperka, Amy A Gelfand, Andrew D Hershey
OBJECTIVE: To describe current patterns of use of nerve blocks and trigger point injections for treatment of pediatric headache. BACKGROUND: Peripheral nerve blocks are often used to treat headaches in adults and children, but the available studies and practice data from adult headache specialists have shown wide variability in diagnostic indications, sites injected, and medication(s) used. The purpose of this study was to describe current practice patterns in the use of nerve blocks and trigger point injections for pediatric headache disorders...
November 2016: Headache
https://www.readbyqxmd.com/read/27704503/myofascial-trigger-point-pain-syndromes
#13
Robert D Gerwin
Myofascial pain syndromes caused by trigger points (TrPs) in muscle are a common cause of local and generalized pain. Trigger points are hyperirritable zones in contracted bands of muscle, thought to be caused by muscle overload or stress. Stress TrPs have characteristic electromyographic features, and can be visualized with ultrasound and magnetic resonance elastography. Trigger point needling or injection can be effective in inactivating TrP, but correcting triggers is also critical.
October 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27679176/transvaginal-trigger-point-injections-for-pelvic-floor-myofascial-spasm-a-retrospective-review-of-pain-assessment-and-development-of-a-treatment-algorithm
#14
L S Fouad, A H Chen, P D Pettit, A Micallef
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27665267/methods-of-fat-tissue-processing-for-human-vocal-cord-injection-a-systematic-review
#15
Giselle M Truzzi, Henrique F Pauna, Patricia Bette, Reinaldo J Gusmão, Agrício N Crespo, Graziela O Semenzati
OBJECTIVES: We analyzed different methods used to process autologous fat tissues for vocal fold injection (VFI). VFI is a safe procedure that preserves the folds' original elasticity and vibration properties and rarely triggers foreign-body reactions, but is often a temporary treatment due to fat reabsorption. To avoid it, selecting a technique that provides as many viable implantable adipocytes as possible is mandatory. STUDY DESIGN: This is a systematic review...
September 21, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27651148/striatal-dopamine-modulates-timing-of-self-initiated-saccades
#16
Jun Kunimatsu, Masaki Tanaka
The ability to adjust movement timing is essential in daily life. Explorations of the underlying neural mechanisms have reported a gradual increase or decrease in neuronal activity prior to self-timed movements within the cortico-basal ganglia loop. Previous studies in both humans and animals have shown that endogenous dopamine (DA) plays a modulatory role in self-timing. However, the specific site of dopaminergic regulation remains elusive because the systemic application of DA-related substances can directly alter both cortical and subcortical neuronal activities...
September 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27621438/cd8-t-cell-mediated-killing-of-orexinergic-neurons-induces-a-narcolepsy-like-phenotype-in-mice
#17
Raphaël Bernard-Valnet, Lidia Yshii, Clémence Quériault, Xuan-Hung Nguyen, Sébastien Arthaud, Magda Rodrigues, Astrid Canivet, Anne-Laure Morel, Arthur Matthys, Jan Bauer, Béatrice Pignolet, Yves Dauvilliers, Christelle Peyron, Roland S Liblau
Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic neurons in the lateral hypothalamus. The genetic and environmental factors associated with narcolepsy, together with serologic data, collectively point to an autoimmune origin. The current animal models of narcolepsy, based on either disruption of the orexinergic neurotransmission or neurons, do not allow study of the potential autoimmune etiology. Here, we sought to generate a mouse model that allows deciphering of the immune mechanisms leading to orexin(+) neuron loss and narcolepsy development...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27604627/microrna-155-enhances-t-cell-trafficking-and-antiviral-effector-function-in-a-model-of-coronavirus-induced-neurologic-disease
#18
Laura L Dickey, Colleen L Worne, Jessica L Glover, Thomas E Lane, Ryan M O'Connell
BACKGROUND: MicroRNAs (miRNAs) are noncoding RNAs that modulate cellular gene expression, primarily at the post-transcriptional level. We sought to examine the functional role of miR-155 in a model of viral-induced neuroinflammation. METHODS: Acute encephalomyelitis and immune-mediated demyelination were induced by intracranial injection with the neurotropic JHM strain of mouse hepatitis virus (JHMV) into C57BL/6 miR-155 (+/+) wildtype (WT) mice or miR-155 (-/-) mice...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27577510/application-of-low-dose-radiation-and-low-concentration-contrast-media-in-enhanced-ct-scans-in-children-with-congenital-heart-disease
#19
Zhimin Liu, Lei Song, Tong Yu, Jun Gao, Qifeng Zhang, Ling Jiang, Yong Liu, Yun Peng
OBJECTIVE: The aim of this study was to explore the feasibility of using low dose radiation and low concentration contrast media in enhanced CT examinations in children with congenital heart disease. MATERIALS AND METHODS: Ninety patients with congenital heart disease were randomly divided into three groups of 30 patients each who underwent contrast-enhanced cardiac scans on a Discovery CT750 HD scanner. Group A received 270 mg I/mL iodixanol, and group B received 320 mg I/mL iodixanol contrast media and was scanned with prospective ECG triggering mode...
September 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27565640/the-treatment-of-chronic-coccydynia-and-postcoccygectomy-pain-with-pelvic-floor-physical-therapy
#20
Kelly M Scott, Lauren W Fisher, Ira H Bernstein, Michelle H Bradley
BACKGROUND: Coccydynia is a challenging disorder that often is refractory to treatments such as medications and injections. Physical therapy for coccydynia rarely has been studied. OBJECTIVE: To evaluate the efficacy of pelvic floor physical therapy for reducing pain levels in patients with coccydynia. DESIGN: Retrospective chart review. SETTING: The pelvic floor rehabilitation clinic of a major university hospital. PATIENTS: A total of 124 consecutive patients over age 18 with a chief complaint of coccydynia between 2009 and 2012...
August 24, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
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