keyword
MENU ▼
Read by QxMD icon Read
search

Pregabalin

keyword
https://www.readbyqxmd.com/read/28436710/ischemic-ulcer-pain-is-both-nociceptive-and-neuropathic-pain-based-on-a-discriminant-function-analysis-using-the-mcgill-pain-questionnaire
#1
Takamichi Kogure, Masahiko Sumitani, Hiroaki Abe, Jun Hozumi, Reo Inoue, Kazuhito Mietani, Kazuo Kawahara, Yoshitsugu Yamada
The McGill Pain Questionnaire (MPQ) is composed of 78 words reflecting the mechanisms underlying chronic pain conditions. Ischemic ulcer pain is generally regarded as a nociceptive and inflammatory pain condition. However, it is sometimes refractory to nonsteroidal anti-inflammatory drug (NSAID) and opioid treatment. We categorized ischemic pain into nociceptive/inflammatory pain (NocP) or neuropathic pain (NeP), on the basis of patients' descriptions of their pain using the MPQ. We investigated pain characteristics of 365 patients with NeP and 124 with NocP using the 78 words of the MPQ...
April 24, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28426255/pregabalin-for-the-treatment-of-neuropathic-pain-a-narrative-review-for-primary-care-providers
#2
Yvonne D'Arcy, Bill McCarberg, Bruce Parsons, Regina Behar, Andrew Thorpe, Andrea Alexander
Neuropathic pain (NeP) is a distinct type of pain caused by damage to the nervous system itself. This often severe and chronic type of pain requires specific treatments that target the underlying pain pathophysiology. The purpose of the current narrative review is to provide an overview of pregabalin (Lyrica®) for the treatment of NeP including its effects on pain, pain-related sleep interference, and other health-related outcomes, timing of therapeutic effect, safety and tolerability, and dosing. The information provided here, along with that in our companion review [1], will help primary care providers develop more effective NeP treatment strategies...
April 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28419825/conversion-of-pregabalin-to-4-isobutylpyrrolidone-2
#3
Amanda M Drachnik, Harshita Kumari, Collin M Mayhan, Drew A Fowler, Wei G Wycoff, Charles L Barnes, John E Adams, Carol A Deakyne, Jerry L Atwood
Solid state studies of C-butyl-resorcin[4]arene with pregabalin (Lyrica, Nervalin) in nitrobenzene yielded a cocrystal of C-butyl-resorcin[4]arene with 4-isobutylpyrrolidone-2. A combined experimental and quantum chemical investigation was implemented to further our understanding of the factors affecting the conversion process.
April 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28419725/healthcare-costs-and-medication-adherence-among-patients-with-fibromyalgia-combination-medication-vs-duloxetine-milnacipran-venlafaxine-and-pregabalin-initiators
#4
Nicole M Marlow, Kit N Simpson, Ivana A Vaughn, Ara Jo, James S Zoller, E Baron Short
OBJECTIVE: To examine medication adherence and healthcare costs for combination prescription initiators (duloxetine/milnacipran/venlafaxine with pregabalin) versus monotherapy initiators (duloxetine, milnacipran, venlafaxine, and pregabalin) among patients with fibromyalgia syndrome (FMS). METHODS: Our retrospective cohort study used claims data for the South Carolina Blue Cross Blue Shield State Health Plan (SHP). Patients with FMS aged ≥18 years, with prescription initiation from July 1, 2007 through June 30, 2010, and SHP enrollment for 12-months pre- and post-index periods were included (combination: N=100, pregabalin: N=665, duloxetine: N=713, milnacipran: N=131, venlafaxine: N=272)...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28413483/morphine-and-pregabalin-in-the-treatment-of-neuropathic-pain
#5
Yue Wang, Helen Yang, Chunjian Shen, Ji Luo
The drugs that are currently available to treat neuropathic pain exhibit inadequate efficacy and numerous adverse effects. The present study compared the efficacy of combination therapy with pregabalin and morphine with that of each as a single agent in patients with neuropathic pain. The primary measurement was mean daily pain intensity. Secondary measurements included a pain questionnaire, adverse effects, mood and quality of life. Combination therapy of morphine plus pregabalin and morphine monotherapy were both more effective at reducing neuropathic pain than pregabalin monotherapy...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28393990/-restless-legs-syndrome-long-term-follow-up-of-a-series-of-patients
#6
Marcelo Miranda C, Lorena Hudson A
BACKGROUND: Restless legs syndrome (RLS) affects 10% of the general population. AIM: To analyze a series of patients with a minimum follow-up period of four years, treated during an interval of 14 years. MATERIAL AND METHODS: Retrospective analysis of medical records of 200 patients assessed and followed by the authors at a private outpatient clinic. RESULTS: Fifty patients aged 25 to 90 years (34 females), who had a mean follow-up of 6,3 years (range 4-14 years), were selected...
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28392896/injury-to-skeletal-muscle-of-mice-following-acute-and-sub-acute-pregabalin-exposure
#7
Mohammad Moshiri, Seyed Adel Moallem, Armin Attaranzadeh, Zahra Saberi, Leila Etemad
OBJECTIVES: Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. MATERIALS AND METHODS: To evaluate the effect of PGB on skeletal muscle, the animals were exposed to a single dose of 1, 2 or 5 g /kg or daily doses of 20, 40 or 80 mg/kg for 21 days, intraperitoneally (IP)...
March 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28389257/physiotherapy-and-speech-and-language-therapy-intervention-for-chronic-cough
#8
REVIEW
Surinder S Birring, Sarah Floyd, Charles C Reilly, Peter Siu Pan Cho
There are few effective pharmacological therapies available to treat refractory chronic cough. Functional MRI studies of the brain have recently shown that patients with chronic cough have dysfunctional inhibitory control of cough. Self-management therapies delivered by physiotherapists or speech therapists are effective at suppressing cough. They enable patients to consciously suppress the urge to cough. The intervention consists of education, laryngeal hygiene, cough suppression and distraction measures and behaviour modification...
April 4, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28382907/pregabalin-risk-of-addiction-and-misuse
#9
Karlheinz Hoffmann
No abstract text is available yet for this article.
March 17, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28378057/tolerability-of-new-antiepileptic-drugs-a-network-meta-analysis
#10
REVIEW
Gaetano Zaccara, Fabio Giovannelli, Filippo Sean Giorgi, Valentina Franco, Sara Gasparini, Umberto Benedetto
OBJECTIVE: The objective of this study was to perform a comparative assessment of tolerability of all licensed new antiepileptic drugs (AEDs) through a network meta-analysis (NMA) including all placebo-controlled double-blind clinical trials (RCTs) in all conditions in which these drugs have been tested. METHODS: NMA with a frequentist approach was used to compare proportions of patients withdrawing because of adverse events (AEs). Analyses were conducted for all therapeutic doses pooled and specifically for high therapeutic doses...
April 4, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28372652/dose-ranging-effects-of-pregabalin-on-pain-in-patients-undergoing-laparoscopic-hysterectomy-a-randomized-double-blinded-placebo-controlled-clinical-trial
#11
Zahra Asgari, Safoura Rouholamin, Masoomeh Nataj, Mahdi Sepidarkish, Reihaneh Hosseini, Maryam Razavi
OBJECTIVE: The study aimed to investigate the preemptive analgesia efficacy of different concentrations (75, 150 and 300mg) of preemptive pregabalin for the postoperative pain management after laparoscopic hysterectomy. DESIGN: Prospective, randomized, placebo-controlled, double-blind study. SETTING: The Gynecology and Obstetrics Center of Arash Hospital, Tehran, Iran, from October 2013 to November 2014. PATIENTS: A total of 96 women with American Association of Anesthesiologist (ASA) physical status I and II underwent elective laparoscopic hysterectomy surgery...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28371941/efficacy-of-mirogabalin-ds-5565-on-patient-reported-pain-and-sleep-interference-in-patients-with-diabetic-neuropathic-pain-secondary-outcomes-of-a-phase-ii-proof-of-concept-study
#12
Domenico Merante, Julio Rosenstock, Uma Sharma, Karen Feins, Ching Hsu, Aaron Vinik
Objective. : To evaluate the effects of mirogabalin on patient-reported pain and sleep interference in diabetic peripheral neuropathic pain (DPNP). Subjects. : Adults (≥18 years) with type 1 or 2 diabetes, glycosylated hemoglobin of 10% or less at screening, and DPNP for six months or more were eligible for participation. Methods.:  Subjects (N = 452) were randomly assigned (2:1:1:1:1:1:1) to receive placebo, dose-ranging mirogabalin (5, 10, 15, 20, 30 mg/day), or pregabalin (300 mg/day) for five weeks...
March 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28370224/do-antiepileptic-drugs-increase-the-risk-of-infectious-diseases-a-meta-analysis-of-placebo-controlled-studies
#13
Gaetano Zaccara, Fabio Giovannelli, Filippo Sean Giorgi, Valentina Franco, Sara Gasparini, Francesco Mandò Tacconi
AIMS: Experimental studies show that some antiepileptic drugs (AEDs) may modify natural immune defenses, thus influencing the risk of developing infectious diseases. The aim of this meta-analysis was to explore whether AEDs as a class of drugs or singularly may increase risk of infectious diseases. METHODS: A meta-analysis of all randomized, double-blind, placebo-controlled trials (RCTs) investigating any AED in any condition was performed. All terms which could be coded in the System Organ Classes (SOCs) of "infections and infestations" using the Medical Dictionary for Regulatory Activities (MedDRA) were recorded...
March 31, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28365034/capsaicin-8-patch-versus-oral-neuropathic-pain-medications-for-the-treatment-of-painful-diabetic-peripheral-neuropathy-a-systematic-literature-review-and-network-meta-analysis
#14
Floortje van Nooten, Maarten Treur, Krystallia Pantiri, Malcolm Stoker, Mata Charokopou
PURPOSE: A network meta-analysis (NMA) was performed, aiming to assess the relative efficacy and tolerability of the capsaicin 179-mg (8% weight for weight) cutaneous patch (capsaicin 8% patch) compared with oral, centrally acting agents (ie, pregabalin, gabapentin, duloxetine, amitriptyline) in patients with painful diabetic peripheral neuropathy (PDPN). METHODS: A systematic search of EMBASE/MEDLINE, Cochrane Library, and the National Health Service Centre for Reviews and Dissemination Database of Abstracts of Reviews of Effects was conducted to identify all randomized controlled trials...
March 29, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28350288/prevalence-and-treatment-of-neuropathic-pain-in-kidney-and-liver-transplant-recipients
#15
Ruhsen Öcal, Ceyda Tanoğlu, Seda Kibaroğlu, Eda Derle, Ufuk Can, Mahir Kirnap, Gökhan Moray, Mehmet Haberal
OBJECTIVES: Neurologic complications are common after kidney and liver transplant. Neurologic complications affect mortality and morbidity in transplant recipients, and neuropathic pain is an important symptom affecting a patient's quality of life. The aim of the present study was to provide readers with our experience regarding causes and treatment of neuropathic pain in patients undergoing kidney and liver transplant at our transplantation center. MATERIALS AND METHODS: The medical data of 553 kidney transplant recipients and 258 liver transplant recipients who received transplant procedures at the Baskent University Transplantation Center between 2008 and May 2016 were retrospectively reviewed...
March 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28348186/biological-rationale-and-potential-clinical-use-of-gabapentin-and-pregabalin-in-bipolar-disorder-insomnia-and-anxiety-protocol-for-a-systematic-review-and-meta-analysis
#16
Kerensa T Houghton, Alexandra Forrest, Amine Awad, Lauren Z Atkinson, Sarah Stockton, Paul J Harrison, John R Geddes, Andrea Cipriani
INTRODUCTION: Gabapentin has been extensively prescribed off-label for psychiatric indications, with little established evidence of efficacy. Gabapentin and pregabalin, a very similar drug with the same mechanism of action, bind to a subunit of voltage-dependent calcium channels which are implicated in the aetiopathogenesis of bipolar disorder, anxiety and insomnia. This systematic review and meta-analysis aims to collect and critically appraise all the available evidence about the efficacy and tolerability of gabapentin and pregabalin in the treatment of bipolar disorder, insomnia and anxiety...
March 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28347837/a-novel-therapeutic-with-two-snap-25-inactivating-proteases-shows-long-lasting-anti-hyperalgesic-activity-in-a-rat-model-of-neuropathic-pain
#17
Jiafu Wang, Laura Casals-Diaz, Tomas Zurawski, Jianghui Meng, Orla Moriarty, John Nealon, Om Prakash Edupuganti, Oliver Dolly
A pressing need exists for long-acting, non-addictive medicines to treat chronic pain, a major societal burden. Botulinum neurotoxin type A (BoNT/A) complex - a potent, specific and prolonged inhibitor of neuro-exocytosis - gives some relief in several pain disorders, but not for all patients. Our study objective was to modify BoNT/A to overcome its inability to block transmitter release elicited by high [Ca(2+)]i and increase its limited analgesic effects. This was achieved by fusing a BoNT/A gene to that for the light chain (LC) of type/E...
March 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28343650/-surveillance-system-on-drug-abuse-interest-of-the-french-national-oppidum-program-of-french-addictovigilance-network
#18
Elisabeth Frauger, Liselotte Pochard, Quentin Boucherie, Adeline Giocanti, Cécile Chevallier, Amélie Daveluy, Valérie Gibaja, Anne-Sylvie Caous, Céline Eiden, Nicolas Authier, Reynald Le Boisselier, Marylène Guerlais, Émilie Jouanjus, Marion Lepelley, Véronique Pizzoglio, Stéphanie Pain, Nathalie Richard, Joëlle Micallef
It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data. OPPIDUM is a cross-sectional survey repeated each year since 1995. In 2015, 5003 patients described the modality of use of 10,159 psychoactive drugs...
February 22, 2017: Thérapie
https://www.readbyqxmd.com/read/28341643/pharmacotherapy-for-diabetic-peripheral-neuropathy-pain-and-quality-of-life-a-systematic-review
#19
Julie M Waldfogel, Suzanne Amato Nesbit, Sydney M Dy, Ritu Sharma, Allen Zhang, Lisa M Wilson, Wendy L Bennett, Hsin-Chieh Yeh, Yohalakshmi Chelladurai, Dorianne Feldman, Karen A Robinson
OBJECTIVE: To systematically assess the effect of pharmacologic treatments of diabetic peripheral neuropathy (DPN) on pain and quality of life. METHODS: We searched PubMed and Cochrane Database of Systematic Reviews for systematic reviews from 2011 to October 12, 2015, and PubMed, Embase, and the Cochrane Central Register of Controlled Trials for primary studies from January 1, 2013, to May 24, 2016. We searched Clinicaltrials.gov on March 9, 2016. Two reviewers independently evaluated studies for eligibility, serially abstracted data, and independently evaluated risk of bias and graded strength of evidence (SOE)...
March 24, 2017: Neurology
https://www.readbyqxmd.com/read/28340617/the-efficacy-of-pregabalin-for-the-management-of-postoperative-pain-in-primary-total-knee-and-hip-arthroplasty-a-meta-analysis
#20
REVIEW
Fei Li, Jianxiong Ma, Mingjie Kuang, Xuan Jiang, Ying Wang, Bin Lu, Xingwen Zhao, Lei Sun, Xinlong Ma
OBJECTIVE: A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy of pregabalin for the management of postoperative pain in patients undergoing primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA). METHOD: The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases were searched for related articles using search strategy. RevMan 5.3 software was selected to conduct the meta-analysis...
March 24, 2017: Journal of Orthopaedic Surgery and Research
keyword
keyword
6557
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"