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Pregabalin

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https://www.readbyqxmd.com/read/27903096/pregabalin-in-tourette-s-syndrome-a-case-series
#1
Marius Hienert, Ana Weidenauer, Christoph Kraus, Matthaeus Willeit, Siegfried Kasper, Mara Stamenkovic
No abstract text is available yet for this article.
December 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27869770/direct-separation-of-pregabalin-enantiomers-using-a-zwitterionic-chiral-selector-by-high-performance-liquid-chromatography-coupled-to-mass-spectrometry-and-ultraviolet-detection
#2
Lakshmi Narayana Chennuru, Thirupathi Choppari, Ramakrishna Prasad Nandula, Tong Zhang, Pilar Franco
The chromatographic resolution of pregabalin enantiomers has been often achieved by derivatization of the molecule, in order to reach enough sensitivity at low concentrations of the minor enantiomer present in the active principle. In the present article, the development and optimization of two liquid chromatographic methods are presented for the direct resolution of pregabalin enantiomers on a chiral stationary phase (CSP) containing a zwitterionic selector derived from cinchona alkaloid and sulfonic acid (CHIRALPAK ZWIX)...
November 19, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27866180/positive-effects-of-uyakujunkisan-therapy-kampo-medicine-for-postherpetic-neuralgia-with-concomitant-pregabalin-two-case-reports-with-a-literature-review
#3
Toshiaki Kogure, Naoyuki Harada, Kanoko Yamamoto, Takeshi Tatsumi
Context • The hallmark of herpes zoster (HZ) is a painful, blistering rash, but neuropathic pain can persist beyond the clearing of the rash and is diagnosed as postherpetic neuralgia (PHN), a chronic pain syndrome. However, the pain in PHN is often refractory to treatment. Objective • The study investigated the ability of Uyakujunkisan (UJS), or Kampo medicine, a traditional herbal medicine, to treat PHN successfully. Design • The study was observational, with discussion of 2 cases. Setting • The study took place in the Department of Japanese Oriental Medicine at Gunma Central and General Hospital (Maebashi, Gunma, Japan)...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27864947/determining-the-toxicological-significance-of-pregabalin-in-fatalities
#4
Simon P Elliott, Timothy Burke, Christopher Smith
Pregabalin has become more widely prescribed and abused in recent years but is still not always included in laboratory analysis. An LC-MS-MS method has been developed and applied to measure pregabalin in 93 postmortem cases, including drug-related deaths, alternative causes of death, and fatalities where pregabalin was likely to have contributed to death. Other drugs or alcohol was detected, and the most common drug types (in decreasing frequency) were antidepressants, opioids, benzodiazepines, opiates, alcohol, antipsychotics, cocaine, cardiac drugs, amphetamines, cannabis, anticonvulsants, and antihistamines...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27862179/the-use-of-a-battery-of-pain-models-to-detect-analgesic-properties-of-compounds-a-two-part-four-way-crossover-study
#5
P Okkerse, G van Amerongen, M L de Kam, J Stevens, R P Butt, R Gurrell, A Dahan, J M van Gerven, J L Hay, G J Groeneveld
AIM: The aim was to investigate the ability of a battery of pain models to detect analgesic properties of commonly used analgesics in healthy subjects. METHODS: The battery consisted of tests eliciting electrical, mechanical and thermal (contact heat and cold pressor)-pain and included a UVB model, the thermal grill illusion and a paradigm of conditioned pain modulation. Subjects were administered fentanyl 3 µg/kg, phenytoin 300 mg, (S)-ketamine 10 mg and placebo (part I), or imipramine 100 mg, pregabalin 300 mg, ibuprofen 600 mg and placebo (part II)...
November 9, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27856776/practice-guideline-summary-treatment-of-restless-legs-syndrome-in-adults-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#6
John W Winkelman, Melissa J Armstrong, Richard P Allen, K Ray Chaudhuri, William Ondo, Claudia Trenkwalder, Phyllis C Zee, Gary S Gronseth, David Gloss, Theresa Zesiewicz
OBJECTIVE: To make evidence-based recommendations regarding restless legs syndrome (RLS) management in adults. METHODS: Articles were classified per the 2004 American Academy of Neurology evidence rating scheme. Recommendations were tied to evidence strength. RESULTS AND RECOMMENDATIONS: In moderate to severe primary RLS, clinicians should consider prescribing medication to reduce RLS symptoms. Strong evidence supports pramipexole, rotigotine, cabergoline, and gabapentin enacarbil use (Level A); moderate evidence supports ropinirole, pregabalin, and IV ferric carboxymaltose use (Level B)...
November 16, 2016: Neurology
https://www.readbyqxmd.com/read/27856391/acute-anti-allodynic-action-of-gabapentin-in-dorsal-horn-and-primary-somatosensory-cortex-correlation-of-behavioural-and-physiological-data
#7
Sascha R A Alles, Mischa V Bandet, Kate Eppler, Myung-Chul Noh, Ian R Winship, Glen Baker, Klaus Ballanyi, Peter A Smith
Neuropathic pain is a debilitating consequence of neuronal injury or disease. Although first line treatments include the alpha-2-delta (α2δ)-ligands, pregabalin and gabapentin (GBP), the mechanism of their anti-allodynic action is poorly understood. One specific paradox is that GBP relieves signs of neuropathic pain in animal models within 30min of an intraperitoneal (IP) injection yet its actions in vitro on spinal dorsal horn or primary afferent neurons take hours to develop. We found, using confocal Ca(2+) imaging, that substantia gelatinosa neurons obtained ex vivo from rats subjected to sciatic chronic constriction injury (CCI) were more excitable than controls...
November 14, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27848217/pregabalin-for-the-treatment-of-drug-and-alcohol-withdrawal-symptoms-a-comprehensive-review
#8
REVIEW
Rainer Freynhagen, Miroslav Backonja, Stephan Schug, Gavin Lyndon, Bruce Parsons, Stephen Watt, Regina Behar
Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids and benzodiazepines), nicotine, alcohol, and cannabinoids are available, but there is still a need for new and more effective therapies. This review examines evidence supporting the potential use of pregabalin, an α2δ voltage-gated calcium channel subunit ligand, for the treatment of physical dependence and associated withdrawal symptoms. A literature search of the MEDLINE and Cochrane Library databases up to and including 11 December 2015 was conducted...
November 16, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27843771/multi-modal-preemptive-analgesia-with-pregabalin-acetaminophen-naproxen-and-dextromethorphan-in-radical-neck-dissection-surgery-a-randomized-clinical-trial
#9
Hamid Reza Amiri, Mojtaba Mirzaei, Mohammad Taghi Beig Mohammadi, Farhad Tavakoli
BACKGROUND: Preemptive analgesia may be considered as a method not only to alleviate postoperative pain but also to decrease analgesic consumption. Different regimens are suggested, but there is currently no standard. OBJECTIVES: The aim was to measure the efficacy of preemptive analgesia with pregabalin, acetaminophen, naproxen, and dextromethorphan in radical neck dissection surgery for reducing the intensity of pain and morphine consumption. PATIENTS AND METHODS: This study was conducted as a randomized double-blind clinical trial...
August 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27843610/survey-of-the-management-of-chemotherapy-induced-peripheral-neuropathy-in-japan-japanese-society-of-medical-oncology
#10
Yasuo Hirayama, Jiichiro Sasaki, Hirotoshi Dosaka-Akita, Kunihiko Ishitani
BACKGROUND: Various drugs are administered for the management of chemotherapy-induced peripheral neuropathy (CIPN) in Japan. However, there have been no surveys undertaken to identify these drugs or their frequency of prescription. Therefore, we administered a questionnaire survey to the diplomates of the Subspecialty Board of Japanese Society of Medical Oncology (JSMO) to investigate the frequency of administration of different drugs for the management of CIPN in Japan. METHODS: We investigated the use of vitamin B12, antiepileptic agents such as pregabalin, duloxetine, antidepressants other than duloxetine, non-steroidal anti-inflammatory drugs (NSAIDs), opioids and the Kampo compound goshajinkigan in a questionnaire employing a three-step scale wherein A implies routine or prophylactic administration, B implies occasional administration and C implies infrequent administration...
2016: ESMO Open
https://www.readbyqxmd.com/read/27826454/pregabalin-prescription-for-terminally-ill-cancer-patients-receiving-specialist-palliative-care-in-an-acute-hospital
#11
Ryo Yajima, Kazuaki Matsumoto, Yuya Ise, Norihito Suzuki, Yuta Yokoyama, Junko Kizu, Shiro Katayama
BACKGROUND: Pregabalin is recommended as an adjuvant analgesic for neuropathic cancer-related pain, and may be taken at all steps of the World Health Organization analgesic ladder. However, unlike opioids, pregabalin treatments are limited to an oral administration route. If patients have oral feeding difficulties, it is not possible to administer any drug as an adjuvant analgesic for neuropathic cancer-related pain. Therefore, the aim of the present study was to clarify the problems of pain control after pregabalin discontinuation in terminally ill cancer patients...
2016: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/27824228/brachioradial-pruritus-in-a-47-year-old-woman-treated-with-pregabalin
#12
Michelangelo Vestita, Luigi Cerbone, Donato Calista
No abstract text is available yet for this article.
December 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27824127/an-observational-longitudinal-study-investigating-the-effectiveness-of-75%C3%A2-mg-pregabalin-post-hemodialysis-among-uremic-pruritus-patients
#13
Tahir Mehmood Khan, David Bin-Chia Wu, Bey-Hing Goh, Learn-Han Lee, Abdul Aziz Alhafez, Syed Azhar Syed Sulaiman
A prospective, observational, longitudinal study was conducted to assess the effectiveness of 75 mg pregabalin (PG) post-hemodialysis (pHD) for treatment-resistant uremic pruritus (UP). A total of forty-five patients completed the entire six week follow-up. At the baseline assessment, the majority of the patients were distressed by the UP frequency and intensity. Sleep (mean = 3.30 ± 1.1), leisure/social activities (mean = 2.90 ± 0.80) and distribution (mean = 2.92 ± 0.34) were the three domains that were primarily effected by the UP...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817842/-pregabalin-induced-parkinsonism-a-case-report
#14
Inès Masmoudi, Valérie Gras-Champel, Dominique Barbieux-Vaquez, Kamel Masmoudi
Pregabalin is not known to induce parkinsonism, one single case is published in the literature. In this work, we report the second case of parkinsonism-induced by this drug in a 58-year old woman initially dosed at 600mg daily for 3 years which was reduced to 300mg daily after the onset of myoclonic jerks and especially because of a weight gain. She is regularly monitored by a neurologist who notes the onset of a parkinsonian syndrome whose asymmetry clinical picture mimicking an idiopathic Parkinson's disease but positron emission tomography (PET scan) was normal and the brain magnetic resonance imaging MRI found a banal leukopathy...
October 15, 2016: Thérapie
https://www.readbyqxmd.com/read/27806445/neuropathic-and-non-neuropathic-chronic-pain-at-gp-encounters-prevalence-patient-characteristics-suffering-and-pregabalin-use
#15
Joan Henderson, Allan J Pollack, Ying Pan, Graeme C Miller
No abstract text is available yet for this article.
November 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27799443/post-herpes-zoster-sunct-like-syndrome-insights-from-two-case-reports
#16
Thomas Mathew, Meghana Srinivas, Sagar Badachi, Raghunandan Nadig
BACKGROUND: SUNCT like syndrome secondary to post herpes zoster infection has not been reported in literature. CASE: We are reporting two cases of SUNCT like syndrome secondary to post herpes zoster infection of the V1 distribution of the trigeminal nerve. Treatment with pregabalin and lamotrigine achieved complete symptomatic relief in both patients. CONCLUSION: SUNCT like syndrome can occur after herpetic infection of the trigeminal nerve...
October 31, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27790557/oral-clonidine-vs-oral-pregabalin-premedication-to-attenuate-pressor-response-to-direct-laryngoscopy-in-patients-undergoing-laparoscopic-cholecystectomy-a-randomized-double-blind-study
#17
Shirin Parveen, Devendra Singh Negi, Rajesh Kumar, Mohd Chand Bagwan
INTRODUCTION: Direct laryngoscopy and tracheal intubation has adverse effects like tachycardia, hypertension, myocardial ischemia and cerebral haemorrhage. There are several studies on various pharmacological agents to attenuate this response. AIM: This study was designed to compare efficacy and safety of oral clonidine and oral pregabalin premedication to attenuate stress response in patients undergoing laparoscopic cholecystectomy. MATERIALS AND METHODS: Total 80 patients of ASA grade I and II, aged between 20-60 years of both sexes scheduled for elective laparoscopic cholecystectomy were included in the study...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785092/improvement-in-pain-severity-category-in-clinical-trials-of-pregabalin
#18
Bruce Parsons, Charles E Argoff, Andrew Clair, Birol Emir
BACKGROUND: Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM), diabetic peripheral neuropathy (DPN), postherpetic neuralgia (PHN), and neuropathic pain due to spinal cord injury (SCI). Approval was based on clinical trial data demonstrating statistically significant differences in pain scores versus placebo. However, statistically significant pain relief may not always equate to clinically meaningful pain relief. To further characterize the clinical benefit of pregabalin, this analysis examined shifts in pain severity categories in patients with FM, DPN/PHN (pooled in this analysis), and SCI treated with pregabalin...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27778062/cytisine-inhibits-the-protective-activity-of-various-classical-and-novel-antiepileptic-drugs-against-6%C3%A2-hz-induced-psychomotor-seizures-in-mice
#19
Piotr Tutka, Maria W Kondrat-Wróbel, Katarzyna Zaluska, Dorota Żółkowska, Magdalena Florek-Łuszczki, Jarogniew J Łuszczki
BACKGROUND: Cytisine (CYT) is a partial agonist of brain α4β2 nicotinic acetylcholine receptors widely used in Central/Eastern Europe for smoking cessation. OBJECTIVES: This study evaluated the effect of CYT on the ability of classical and novel antiepileptic drugs to prevent seizures evoked by the 6-Hz test, a model of psychomotor seizures in mice thought as a model of drug-resistant seizures. RESULTS: CYT administered intraperitoneally (i...
October 25, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27766590/an-updated-overview-on-therapeutic-drug-monitoring-of-recent-antiepileptic-drugs
#20
REVIEW
Shery Jacob, Anroop B Nair
Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs), therapeutic drug monitoring (TDM) can make a significant contribution to the field of epilepsy. The measurement and interpretation of serum drug concentrations can be of benefit in the treatment of uncontrollable seizures and in cases of clinical toxicity; it can aid in the individualization of therapy and in adjusting for variable or nonlinear pharmacokinetics; and can be useful in special populations such as pregnancy. This review examines the potential for TDM of newer AEDs such as eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, perampanel, pregabalin, rufinamide, retigabine, stiripentol, tiagabine, topiramate, vigabatrin, and zonisamide...
December 2016: Drugs in R&D
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