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Pregabalin

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https://www.readbyqxmd.com/read/29781509/comparative-analgesic-efficacy-of-pregabalin-administered-according-to-either-a-prevention-protocol-or-an-intervention-protocol-in-rats-with-cisplatin-induced-peripheral-neuropathy
#1
F Y Han, A Kuo, J R Nicholson, L Corradinni, M T Smith
Chemotherapy-induced peripheral neuropathy (CIPN) is a type of peripheral neuropathic pain that may be dose-limiting in patients administered potentially curative cancer chemotherapy dosing regimens. In cancer survivors, persistent CIPN adversely affects patient quality of life and so adjuvant drugs (anticonvulsants e.g. pregabalin or antidepressants e.g. amitriptyline) are recommended for the relief of CIPN. However, most studies in rodent models of CIPN involve administration of single bolus doses of adjuvant drugs to assess pain-relieving efficacy...
May 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29766827/pain-related-behavior-and-brain-activation-in-a-cynomolgus-macaque-model-of-postoperative-pain
#2
Aldric Hama, Takahiro Natsume, Shin'ya Ogawa, Yūji Awaga, Ikuo Hayashi, Akihisa Matsuda, Hiroyuki Takamatsu
BACKGROUND: Inadequate postoperative pain management could lead to persistent pain and this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical model of postoperative pain was developed in the cynomolgus macaque, a species that is phylogenetically closer to humans than rodents. METHOD: The presence of pressure hypersensitivity was assessed with non-noxious pressure applied proximally and distally (approximately 10 cm) to an abdominal incision in macaques...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29763267/top-20-research-studies-of-2017-for-primary-care-physicians
#3
Mark H Ebell, Roland Grad
Based on systematic surveillance of more than 110 medical journals, 247 studies met criteria as POEMs (patient-oriented evidence that matters) in 2017. Members of the Canadian Medical Association identified 20 of these POEMs as most relevant to practice. This article reviews the clinical questions and bottom-line answers from these studies. Blood pressure should be measured after a period of rest, using a bare arm, and orthostatic blood pressure is more predictive when measured after one minute of standing rather than three minutes...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29763265/pregabalin-lyrica-for-acute-fibromyalgia-pain
#4
Luke Donnelly, Jaime Moran, Mathew Foley
No abstract text is available yet for this article.
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29757758/ultrasound-guided-pulsed-radiofrequency-in-the-management-of-thoracic-post-herpetic-neuralgia-a-randomized-double-blinded-controlled-trial
#5
Mohamed Y Makharita, Hanaa M El Bendary, Zainab M Sonbul, Salma El Sayed Ahmed, Mahmoud Abdel Latif
OBJECTIVES: This study was designed to evaluate the efficacy and safety of ultrasound-guided pulsed radiofrequency (PRF) for the intercostal nerves (ICNs) in the management of thoracic post-herpetic neuralgia (PHN). METHODS: After 2 weeks of treatment by pregabalin 150▒mg/12 hours, patients were randomly allocated into 2 groups. The PRF group, after ultrasound-guided localization of the ICN of the affected thoracic dermatome, sensory stimulation of the ICN was tested...
May 11, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29756335/treatment-of-restless-legs-syndrome-evidence-based-review-and-implications-for-clinical-practice-revised-2017-%C3%A2
#6
REVIEW
Juliane Winkelmann, Richard P Allen, Birgit Högl, Yuichi Inoue, Wolfgang Oertel, Aaro V Salminen, John W Winkelman, Claudia Trenkwalder, Cristina Sampaio
The objective of the current review was to update the previous evidence-based medicine review of treatments for restless legs syndrome published in 2008. All randomized, controlled trials (level I) with a high quality score published between January 2007 and January 2017 were reviewed. Forty new studies qualified for efficacy review. Pregabalin, gabapentin enacarbil, and oxycodone/naloxone, which did not appear in the previous review, have accrued data to be considered efficacious. Likewise, new data enable the modification of the level of efficacy for rotigotine from likely efficacious to efficacious...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29754518/cost-of-treating-peripheral-neuropathic-pain-with-pregabalin-or-gabapentin-at-therapeutic-doses-in-routine-practice
#7
Antoni Sicras-Mainar, Javier Rejas-Gutiérrez, Maria Perez-Paramo, Ruth Navarro-Artieda
AIM: To analyze the cost of peripheral neuropathic pain (PNP) treatment with pregabalin or gabapentin at therapeutic doses in routine clinical practice. METHODS: Analysis of a retrospective, observational study of electronic medical records of patients treated for PNP with therapeutic doses of pregabalin or gabapentin, with 2 years' follow-up, considering PNP type, comorbidities, concomitant analgesia and resource use. RESULTS: The weighted total average cost/patient was lower for pregabalin than gabapentin (€2464 [2197-2730] vs €3142 [2670-3614]; p = 0...
May 14, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29748103/gabapentin-as-an-adjunct-to-standard-postoperative-pain-management-protocol-in-lower-extremity-surgery
#8
REVIEW
P Andrew Crisologo, Erik K Monson, Said A Atway
Postoperative pain is a problem that plagues physicians and has since the dawn of the surgical arts. Many interventions are available and used as the standard such as preoperative local anesthetic blocks, opiates, both oral and intravenous, and nonsteroidal antiinflammatory drugs. Although the temptation often exists to increase the postoperative opiate dose, opiate abuse is an increasing problem. This abuse has fueled the search for nonopiate pain adjuncts. Gabapentinoids have been shown to both decrease postoperative pain and, secondarily, decrease opiate dependence...
May 7, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#9
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29738803/standard-analgesics-reverse-burrowing-deficits-in-a-rat-cci-model-of-neuropathic-pain-but-not-in-models-of-type-1-and-type-2-diabetes-induced-neuropathic-pain
#10
Kris Rutten, Stacey A Gould, Luke Bryden, Henri Doods, Thomas Christoph, Anton Pekcec
BACKGROUND: Burrowing is a rodent behavior validated as a robust and reproducible outcome measure to infer the global effect of pain in several inflammatory pain models. However, less is known about the effect of analgesics on burrowing in neuropathic pain models and no studies have determined burrowing performance in models of diabetes-associated neuropathic pain. OBJECTIVE: To compare the sensitivity of the burrowing assay in different neuropathic pain models: mononeuropathic pain and diabetic polyneuropathy...
May 5, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29730463/endodontic-related-inferior-alveolar-nerve-injuries-a-review-and-a-therapeutic-flow-chart
#11
R Castro, M Guivarch, J M Foletti, J H Catherine, C Chossegros, L Guyot
INTRODUCTION: Inferior alveolar nerve (IAN) lesions related to endodontic treatments can be explained by the anatomical proximity between the apices of the mandibular posterior teeth and the mandibular canal. The aim of this article is to review the management of inferior alveolar nerve lesions due to endodontic treatments and to establish a therapeutic flow chart. METHODS: A review of publications reporting IAN damage related to endodontic treatment over the past 20 years has been conducted, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist; it combines an electronic search of the PubMed® and Google Scholar® databasis...
May 3, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29730418/effects-of-pregabalin-on-brain-edema-neurologic-and-histologic-outcomes-in-experimental-traumatic-brain-injury
#12
Manzumeh-Shamsi Meymandi, Zahra Soltani, Gholamreza Sepehri, Sedigheh Amiresmaili, Fatemeh Farahani, Mohammadmehdi Moeini Aghtaei
Brain edema and increased intracranial pressure (ICP) are among the main causes of neurological disturbance and mortality following traumatic brain injury (TBI). Since pregabalin neuroprotective effects have been shown, this study was performed to evaluate the possible neuroprotective effects of pregabalin in experimental TBI of male rats. Adult male Wistar rats were divided into 4 groups: sham, vehicle, pregabalin 30 mg/kg and pregabalin 60 mg/kg. TBI was induced in vehicle and pregabalin groups by Marmarou method...
May 3, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29719278/clinical-and-electrocorticographic-response-to-antiepileptic-drugs-in-patients-treated-with-responsive-stimulation
#13
Tara L Skarpaas, Thomas K Tcheng, Martha J Morrell
OBJECTIVE: The objective of this study was to explore whether chronic electrocorticographic (ECoG) data recorded by a responsive neurostimulation system could be used to assess clinical responses to antiepileptic drugs (AEDs). METHODS: Antiepileptic drugs initiated and maintained for ≥3 months by patients participating in clinical trials of the RNS® System were identified. Such "AED Starts" that produced an additional ≥50% reduction in patient-reported clinical seizure frequency were categorized as clinically beneficial, and the remaining as not beneficial...
April 29, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29714818/synthesis-of-beta-substituted-gamma-aminobutyric-acid-derivatives-via-enantioselective-photoredox-catalysis
#14
Jiajia Ma, Jiahui Lin, Lifang Zhao, Klaus Harms, Michael Marsch, Xiulan Xie, Eric Meggers
Beta-Substituted chiral gamma-aminobutyric acids display important biological activities and are valuable intermediates for the synthesis of pharmaceuticals. Herein we report an efficient catalytic enantioselective approach for the synthesis of beta-substituted gamma-aminobutyric acid derivatives through visible-light-induced photocatalyst-free asymmetric radical conjugate additions. Various beta-substituted gamma-aminobutyric acid analogs, including previously inaccessible derivatives containing fluorinated quaternary stereocenters, were obtained in good yields (53-89%) and with excellent enantioselectivities (90-97% ee)...
April 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29709457/diabetic-peripheral-neuropathy-epidemiology-diagnosis-and-pharmacotherapy
#15
REVIEW
Zohaib Iqbal, Shazli Azmi, Rahul Yadav, Maryam Ferdousi, Mohit Kumar, Daniel J Cuthbertson, Jonathan Lim, Rayaz A Malik, Uazman Alam
PURPOSE: Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy worldwide, and its prevalence increases with the duration of diabetes. It affects approximately half of patients with diabetes. DPN is symmetric and predominantly sensory, starting distally and gradually spreading proximally in a glove-and-stocking distribution. It causes substantial morbidity and is associated with increased mortality. The unrelenting nature of pain in this condition can negatively affect a patient's sleep, mood, and functionality and result in a poor quality of life...
April 27, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29705022/comorbid-thyroid-disease-in-patients-with-major-depressive-disorder-results-from-the-european-group-for-the-study-of-resistant-depression-gsrd
#16
Gernot Fugger, Markus Dold, Lucie Bartova, Alexander Kautzky, Daniel Souery, Julien Mendlewicz, Alessandro Serretti, Joseph Zohar, Stuart Montgomery, Richard Frey, Siegfried Kasper
This multicenter study of the European Group for the Study of Resistant Depression (GSRD) aimed to explore the association between major depressive disorder (MDD) and comorbid thyroid disease. A total number of 1410 patients` characteristics in terms of demographic and clinical information were compared between MDD subjects with and without concurrent thyroid disease using descriptive statistics, analyses of covariance (ANCOVA) and binary logistic regression analyses. We determined a point prevalence rate for comorbid hypothyroidism of 13...
April 25, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29704151/extracellular-matrix-remodeling-and-modulation-of-inflammation-and-oxidative-stress-by-sulforaphane-in-experimental-diabetic-peripheral-neuropathy
#17
Passant E Moustafa, Noha F Abdelkader, Sally A El Awdan, Osama A El-Shabrawy, Hala F Zaki
The peripheral nervous system is one of many organ systems that can be profoundly impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative effect on patients' quality of life as it begins with loss of limbs' sensation and may result in lower limb amputation. This investigation aimed at exploring the effect of sulforaphane on peripheral neuropathy in diabetic rats. Experimental diabetes was induced through single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52...
April 27, 2018: Inflammation
https://www.readbyqxmd.com/read/29690558/abuse-of-prescription-drugs-in-the-context-of-novel-psychoactive-substances-nps-a-systematic-review
#18
REVIEW
Fabrizio Schifano, Stefania Chiappini, John M Corkery, Amira Guirguis
Recently, a range of prescription and over-the-counter drugs have been reportedly used as Novel Psychoactive Substances (NPS), due to their potential for abuse resulting from their high dosage/idiosyncratic methods of self-administration. This paper provides a systematic review of the topic, focusing on a range of medications which have emerged as being used recreationally, either on their own or in combination with NPS. Among gabapentinoids, pregabalin may present with higher addictive liability levels than gabapentin, with pregabalin being mostly identified in the context of opioid, polydrug intake...
April 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29684922/saliva-versus-plasma-therapeutic-drug-monitoring-of-pregabalin-in-jordanian-patients
#19
Nasir Idkaidek, Salim Hamadi, Manal El-Assi, Ahmad Al-Shalalfeh, Ahmad Al-Ghazawi
The objective is using saliva instead of plasma for pregabalin therapeutic drug monitoring (TDM) since saliva reflects the free non-protein bound drug concentration, simple and noninvasive sampling, cheaper and does not require the expertise of drawing blood. Forty four patients participated in this study, two samples of saliva and another two of blood were taken from each patient; first sample of both saliva and blood is the trough sample and was taken just before the first dose of the day and second sample is the peak sample and was taken 1 h after taking the first dose of the day...
April 23, 2018: Drug Research
https://www.readbyqxmd.com/read/29680426/willis-ekbom-disease-restless-legs-syndrome-in-patients-with-opioid-withdrawal
#20
Ravi Gupta, Ramjan Ali, Rajat Ray
INTRODUCTION: Many patients with opioid use disorder report symptoms similar to restless legs syndrome (RLS) during withdrawal. However, whether these symptoms are true RLS, their predictors and effect of treatment with pregabalin are still unknown. METHOD: A total of 19 consecutive patients with opioid use disorder who were admitted for detoxification were included in this study after obtaining informed consent. Information regarding addiction was noted, and they were screened for RLS every morning and evening...
May 2018: Sleep Medicine
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