keyword
MENU ▼
Read by QxMD icon Read
search

Pregabalin

keyword
https://www.readbyqxmd.com/read/29344445/comparing-postoperative-complications-and-inflammatory-markers-using-total-intravenous-anesthesia-versus-volatile-gas-anesthesia-for-pancreatic-cancer-surgery
#1
Jose M Soliz, Ifeyinwa C Ifeanyi, Mathew H Katz, Jonathan Wilks, Juan P Cata, Thomas McHugh, Jason B Fleming, Lei Feng, Thomas Rahlfs, Morgan Bruno, Vijaya Gottumukkala
Objectives: The objective of this study is to evaluate postoperative complications and inflammatory profiles when using a total intravenous anesthesia (TIVA) or volatile gas-opioid (VO) based anesthesia in patients undergoing pancreatic cancer surgery. Methods: Design, retrospective propensity score matched cohort; Setting, major academic cancer hospital; Patients, all patients who had pancreatic surgery between November 2011 and August 2014 were retrospectively reviewed...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29343477/role-of-asic3-nav1-7-and-nav1-8-in-electroacupuncture-induced-analgesia-in-a-mouse-model-of-fibromyalgia-pain
#2
Liang-Ta Yen, Yu-Chan Hsu, Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Lin
BACKGROUND: The mechanisms underlying fibromyalgia (FM) pain are not understood. The US Food and Drug Administration has recommended three drugs for treating FM-namely, pregabalin, duloxetine and milnacipran; however, these medications are associated with severe side effects. OBJECTIVE: To create a mouse model of FM pain using dual injections of acidic saline to cause mechanical hyperalgesia and test whether ASIC3, Nav1.7 and Nav1.8 are involved in this process and whether electroacupuncture (EA) can reverse these phenomena...
January 17, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29343280/pregabalin-versus-placebo-in-targeting-pro-nociceptive-mechanisms-to-prevent-chronic-pain-after-whiplash-injury-in-at-risk-individuals-a-feasibility-study-for-a-randomised-controlled-trial
#3
J Nikles, G Keijzers, G Mitchell, S Schug, R Ware, S A McLean, L Connelly, S Gibson, S F Farrell, M Sterling
BACKGROUND: Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of central sensitization is associated with poor recovery. Pregabalin's effects on central sensitization indicate the potential to prevent or modulate these processes after whiplash injury and to improve health outcomes, but this has not been investigated...
January 17, 2018: Trials
https://www.readbyqxmd.com/read/29334589/preparation-and-evaluation-of-a-deoxycholic-calix-4-arene-hybrid-type-receptor-as-a-chiral-stationary-phase-for-hplc
#4
Sadegh Yaghoubnejad, Kourosh Tabar Heydar, Seyyed Hamid Ahmadi, Reza Zadmard, Nima Ghonouei
We report the synthesis and enantioseparation characteristics of two novel covalently immobilized deoxycholic acid derivatives as chiral stationary phases for high-performance liquid chromatography. In the structure of the first stationary phase, the 3-position of deoxycholic acid is substituted with a 3,5-dinitrophenylcarbamoyl group and the second one has an additional calix[4]arene attached to the carboxylic group of the deoxycholic acid. The chromatographic performance of the stationary phases was evaluated with enantioseparation of N-(3,5-dinitrobenzoyl)-dl-leucine, N-(3,5-dinitrobenzoyl)-dl-valine, omeprazole, diclofop-methyl, dl-mandelic acid and (RS)-pregabalin...
January 15, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29324521/the-efficacy-of-transcranical-direct-current-stimulation-in-pregabalin-abuse-a-case-report
#5
Matteo Lupi, Gianna Sepede, Eduardo Cinosi, Giovanni Martinotti, Massimo di Giannantonio
No abstract text is available yet for this article.
January 11, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29319453/evaluating-the-effectiveness-of-antidepressant-therapy-adjuvant-to-gabapentin-and-pregabalin-for-treatment-of-sci-related-neuropathic-pain
#6
Emily Carol McKinley, Elizabeth J Richardson, Gerald McGwin, Jie Zhang
OBJECTIVE: To investigate if a combination of anticonvulsant and antidepressant, two primary therapies for neuropathic pain, is associated with improved pain control compared to individual therapy. DESIGN: Prospective cohort study Setting: The University of Alabama at Birmingham Rehabilitation Center In-patient Program between 2012 and 2015. PARTICIPANTS: Incident SCI cases, 19-65 years of age. OUTCOMES: Bryce-Ragnarsson pain classification scheme and the Numerical Rating Scale Results: Twenty-nine eligible patients completed 6-month follow-up; their average age was 36...
January 10, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29317396/pregabalin-as-adjunctive-therapy-in-benzodiazepine-discontinuation
#7
Kaylee Caniff, Emily Telega, Jolene R Bostwick, Kristen N Gardner
PURPOSE: The available evidence for the use of pregabalin as adjunctive therapy in the discontinuation of benzodiazepines is reviewed. SUMMARY: Pregabalin has been studied as an adjunctive pharmacologic treatment for the discontinuation of long-term benzodiazepine use. Unlike carbamazepine, pregabalin has little potential for drug interactions, and its adverse effects are mostly mild and transient. Pregabalin reduces the release of excitatory neurotransmitters by binding to regulatory subunits of voltage-activated calcium channels...
January 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29316960/pregabalin-versus-gabapentin-in-the-treatment-of-sciatica-study-protocol-for-a-randomised-double-blind-cross-over-trial-pagpros
#8
Kelvin Robertson, Laurence A G Marshman, Maria Hennessy, Linton Harriss, David Plummer
BACKGROUND: There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite equipoise, most countries' formulary regulatory authorities typically favour one drug for subsidy over the other. This hinders interchange wherever the favoured drug is either ineffective or not tolerated...
January 9, 2018: Trials
https://www.readbyqxmd.com/read/29308685/randomized-trial-of-preoperative-administration-of-oral-pregabalin-for-postoperative-analgesia-in-patients-scheduled-for-radiofrequency-ablation-of-focal-lesions-in-the-liver
#9
Amr Ahmed Magdy Abdelfattah, Fatma Rizk, Nehad Hawash, Amr Hanafy, Ferial El-Kalla, Sherief Abd-Elsalam
PURPOSE: The aim of this study was to evaluate the effect of preoperative pregabalin on postoperative analgesia in patients undergoing radiofrequency ablation (RFA) of hepatic focal lesions (HFLs). METHODS: This randomized controlled study was carried out on 70 adult patients for whom RFA was indicated to treat hepatocellular carcinoma. They were randomized into two groups: Group I: 35 patients who were given a placebo before the procedure and Group II: 35 patients who were given 150 mg of oral pregabalin one hour before the procedure...
January 7, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29286353/is-perioperative-pregabalin-effective-for-reducing-postoperative-pain-in-major-surgery
#10
José Canihuante, Ian Molina, Fernando Altermatt
INTRODUCTION: Pregabalin is a structural analog of γ-aminobutyric acid that may have a role in acute pain management. It has been used in the perioperative context, but there is controversy regarding its real clinical utility. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
December 27, 2017: Medwave
https://www.readbyqxmd.com/read/29280313/efficacy-and-safety-of-oxycodone-naloxone-as-add-on-therapy-to-gabapentin-or-pregabalin-for-the-management-of-chemotherapy-induced-peripheral-neuropathy-in-korea
#11
Bong-Seog Kim, Jong-Youl Jin, Jung Hye Kwon, In Sook Woo, Yoon Ho Ko, Suk-Young Park, Hye-Jeong Park, Jin Hyung Kang
AIMS: To investigate the efficacy and safety of oxycodone/naloxone in patients with chemotherapy-induced peripheral neuropathy (CIPN) inadequately controlled with pregabalin or gabapentin. METHODS: This 4-week, multicenter, interventional, single-arm phase IV study included 72 Korean patients with CIPN inadequately controlled with pregabalin or gabapentin (Numeric Rating Scale 0-10; NRS ≥4 at baseline). In addition to pregabalin or gabapentin at existing doses, patients received 20/10 mg/day oxycodone/naloxone (up-titrated to 80/40 mg/day as needed)...
December 27, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29280233/operant-self-administration-of-pregabalin-in-a-mouse-model-of-neuropathic-pain
#12
S A Bura, D Cabañero, R Maldonado
BACKGROUND: Pregabalin is a first-line agent for neuropathic pain treatment whose abuse liability remains controversial. Surprisingly, studies exploring the reinforcing properties of pregabalin in operant mouse models are missing. METHODS: We evaluated the acquisition of operant pregabalin self-administration in mice exposed to a partial sciatic nerve ligation (PSNL) or a sham operation. After surgery, mice were trained in operant boxes to intravenously self-administer pregabalin at 1...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29275640/lost-in-translation-a-critical-look-at-the-role-that-animal-models-of-obsessive-compulsive-disorder-play-in-current-drug-discovery-strategies
#13
Kurt Leroy Hoffman, Hugo Cano-Ramírez
Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric illness estimated to affect between 1-3% of the population. In today's literature, there are a number well-validated and convincing animal models of OCD described. Areas covered: Herein, the authors look at the role that animal models of OCD (including transgenic models, deer mouse stereotypy, quinpirole sensitization, post-training signal attenuation, and mouse marble burying) have played in determining the current directions of OCD drug discovery...
December 23, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29245223/effect-of-preoperative-pregabalin-as-an-adjunct-to-a-multimodal-analgesic-regimen-in-video-assisted-thoracoscopic-surgery-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Jong Chan Kim, Sunghye Byun, Seongsu Kim, Seon-Yi Lee, Joo Hyung Lee, Sowoon Ahn
BACKGROUND: Depending on the type of injury, the pain mechanisms are multifactorial. Preoperative pregabalin administrations as an adjunct to a multimodal postoperative pain management strategy have been tested in various surgical settings. The purpose of current study was to evaluate the effects of preoperative pregabalin administration on postoperative pain intensity and rescue analgesic requirement following video-assisted thoracoscopic surgery (VATS). METHODS: Sixty adult patients undergoing VATS were randomly assigned either to receive pregabalin 150 mg (Pregabalin group) or placebo (Control group) 1 hour before anesthesia...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29231316/-resuscitation-acupuncture-for-thalamic-pain-a-randomized-controlled-trial
#15
Yajie Li, Hao Tian, Li An, Xuemin Shi
OBJECTIVE: To compare the effects between resuscitation acupuncture and pregabalin for thalamic pain and their impacts on plasma P substance (SP) and β-endorphin (β-EP). METHODS: Sixty-four patients were randomly assigned into an acupuncture group and a western medication group, 32 cases in each one. Based on conventional western methods, pregabalin capsule was used orally in the western medication group, 75 mg a time,twice a day; resuscitation acupuncture was applied in the acupuncture group...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29227577/management-of-pain-in-end-stage-renal-disease-patients-short-review
#16
REVIEW
Rupesh Raina, Vinod Krishnappa, Mona Gupta
Pain management in end stage renal disease (ESRD) patients is a complex and challenging task to accomplish, and effective pain and symptom control improves quality of life. Pain is prevalent in more than 50% of hemodialysis patients and up to 75% of these patients are treated ineffectively due to its poor recognition by providers. A good history for PQRST factors and intensity assessment using visual analog scale are the initial steps in the management of pain followed by involvement of palliative care, patient and family counseling, discussion of treatment options, and correction of reversible causes...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29218466/acute-herpes-zoster-and-post-herpetic-neuralgia-in-primary-care-a-study-of-diagnosis-treatment-and-cost
#17
Brendan Crosbie, Sinead Lucey, Lesley Tilson, Lisa Domegan, Jennifer Kieran
Acute herpes zoster and its complication post herpetic neuralgia represent a significant challenge to primary care physicians in their care of an ageing population of patients. This was a cross-sectional observational study by means of a quantitative survey of 1,000 general practitioners registered in Ireland exploring the frequency of diagnosis, methods of treatment and cost of AHZ and PHN in primary care. We recorded an 18% response rate (n = 184) with an 83% completion rate (n = 152/184). 80% of cases of AHZ occurred in patients aged 50 years or more with 81% of study participants encountering cases at a rate of 1-3 patients per month...
December 7, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29214743/gc-ms-ms-detects-potential-pregabalin-abuse-in-susceptible-subjects-hair
#18
Federica Ianni, Kyriaki Aroni, Alessio Gili, Roccaldo Sardella, Mauro Bacci, Massimo Lancia, Benedetto Natalini, Cristiana Gambelunghe
Pregabalin, a GABA analogue, binds to the alpha 2 delta subunit of voltage-dependent calcium channels. It is recognized as efficacious in pathologies such as epilepsy, neuropathic pain and anxiety disorders. Since pregabalin prescriptions have increased worldwide, reports of its abuse have been accumulating, mainly in patients with opioid abuse disorders. The present study investigated potential pregabalin abuse by means of hair analysis, a matrix that provides valuable retrospective information. Half of the pool of 280 susceptible patients had been occasional drug users and were being monitored for driving licence renewals...
December 7, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29202395/generalized-unprovoked-vulvodynia-a-retrospective-study-on-the-efficacy-of-treatment-with-amitriptyline-gabapentin-or-pregabalin
#19
Heleen J van Beekhuizen, Jessica Oost, Willem I van der Meijden
OBJECTIVE: To describe patient characteristics of women diagnosed with generalized unprovoked vulvodynia (GUV) and to estimate efficacy and tolerability of treatment. MATERIAL AND METHODS: Retrospective observational study in 241 women who presented with GUV at three vulvar disease clinics in Rotterdam, The Netherlands during 1996-2013. Main outcome was efficacy of amitriptyline, gabapentin or pregabalin treatment. RESULTS: The median duration of symptoms was 24 months and median age 62 years (range 36-89)...
January 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29194851/superiority-of-capsaicin-8-patch-versus-oral-pregabalin-on-dynamic-mechanical-allodynia-in-patients-with-peripheral-neuropathic-pain
#20
G Cruccu, T J Nurmikko, E Ernault, F K Riaz, W T McBride, M Haanpää
BACKGROUND: Dynamic Mechanical Allodynia (DMA) is a typical symptom of neuropathic pain (NP). In a recent study, the capsaicin 8% patch was noninferior to pregabalin in overall peripheral NP relief. In this study, we report the comparison of the two treatments in relieving DMA. METHODS: In a randomized, open-label, head-to-head, 8-week study, 488 patients with peripheral NP were treated with the capsaicin 8% patch (one application) or an optimized dose of pregabalin...
December 1, 2017: European Journal of Pain: EJP
keyword
keyword
6557
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"