Annerose E Ziegler, Pia Fittje, Luisa M Müller, Annika E Ahrenstorf, Kerri Hagemann, Sven H Hagen, Leonard U Hess, Annika Niehrs, Tobias Poch, Gevitha Ravichandran, Sebastian M Löbl, Benedetta Padoan, Sébastien Brias, Jana Hennesen, Myrtille Richard, Laura Richert, Sven Peine, Karl J Oldhafer, Lutz Fischer, Christoph Schramm, Glòria Martrus, Madeleine J Bunders, Marcus Altfeld, Sebastian Lunemann
The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory receptor TIGIT decreases NK cell cytotoxicity and is involved in NK cell exhaustion, but has also been associated with liver regeneration, highlighting that the contribution of human intrahepatic CD56bright NK cells in regulating tissue homeostasis remains incompletely understood. A targeted single-cell mRNA analysis revealed distinct transcriptional differences between matched human peripheral blood and intrahepatic CD56bright NK cells...
2023: Frontiers in Immunology