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CD226

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https://www.readbyqxmd.com/read/27883251/mir-892a-promotes-hepatocellular-carcinoma-cells-proliferation-and-invasion-through-targeting-cd226
#1
Baoxing Jia, Ludong Tan, Zhe Jin, Yan Jiao, Yu Fu, Yahui Liu
Our study is aim to investigate the influence of miR-892a on proliferative and invasive activities of human hepatocellular carcinoma (HCC) cells through regulating CD226 expression. QRT-PCR was used to detect the expression levels of miR-892a and CD226 mRNA in HCC tissues and adjacent tissues or HCC cells and normal cells whereas Western Blot was used to detect the CD226 protein expression in tissue and cell samples. Then HuH-7 cell line was selected for following assays and respectively transfected with miR-892a mimics, miR-NC, Plenti-GIII-Ubc-CD226, and Plenti-GIII-Ubc followed by qRT-PCR assay to detect the miR-892a and CD226 expression...
November 24, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27733551/distinct-roles-for-human-cytomegalovirus-immediate-early-proteins-ie1-and-ie2-in-the-transcriptional-regulation-of-mica-and-pvr-cd155-expression
#2
Benedetta Pignoloni, Cinzia Fionda, Valentina Dell'Oste, Anna Luganini, Marco Cippitelli, Alessandra Zingoni, Santo Landolfo, Giorgio Gribaudo, Angela Santoni, Cristina Cerboni
Elimination of virus-infected cells by cytotoxic lymphocytes is triggered by activating receptors, among which NKG2D and DNAM-1/CD226 play an important role. Their ligands, that is, MHC class I-related chain (MIC) A/B and UL16-binding proteins (ULBP)1-6 (NKG2D ligand), Nectin-2/CD112, and poliovirus receptor (PVR)/CD155 (DNAM-1 ligand), are often induced on virus-infected cells, although some viruses, including human CMV (HCMV), can block their expression. In this study, we report that infection of different cell types with laboratory or low-passage HCMV strains upregulated MICA, ULBP3, and PVR, with NKG2D and DNAM-1 playing a role in NK cell-mediated lysis of infected cells...
October 12, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27722794/gene-gene-interaction-between-cd40-and-cd226-gene-on-systemic-lupus-erythematosus-in-the-chinese-han-population
#3
Daqing Nie, Hongbo Li, Guixiu Yan, Zhengyi Wang, Zhaomin He, Wenyu Zhou
The aim of the study is to investigate the impact of CD40 and CD226 gene single-nucleotide polymorphism (SNP) and additional gene-gene interaction on systemic lupus erythematosus (SLE) risk in Chinese Han populations. Three SNPs were selected for genotyping in the case-control study: rs4810485, rs763361, and rs3765456. Logistic regression was performed to investigate association between SNP within CD40 and CD226 and SLE. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the interaction among three SNPs...
October 8, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27626490/altered-expression-of-cd226-and-cd96-on-natural-killer-cells-in-patients-with-pancreatic-cancer
#4
Yun-Peng Peng, Chun-Hua Xi, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Jing-Jing Zhang, Xin-Chun Liu, Song Guo, Yue Fu, Yi Miao
The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. Expression of these molecules on NK cells was detected from samples of 92 pancreatic cancer patients and 40 healthy controls. The expression of CD155 was also evaluated by immunohistochemistry in 88 pancreatic cancer tissues...
September 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27622043/il12-mediated-sensitizing-of-t-cell-receptor-dependent-and-independent-tumor-cell-killing
#5
Matthias Braun, Marie L Ress, Young-Eun Yoo, Claus J Scholz, Matthias Eyrich, Paul G Schlegel, Matthias Wölfl
Interleukin 12 (IL12) is a key inflammatory cytokine critically influencing Th1/Tc1-T-cell responses at the time of initial antigen encounter. Therefore, it may be exploited for cancer immunotherapy. Here, we investigated how IL12, and other inflammatory cytokines, shape effector functions of human T-cells. Using a defined culture system, we followed the gradual differentiation and function of antigen-specific CD8(+) T cells from their initial activation as naïve T cells through their expansion phase as early memory cells to full differentiation as clonally expanded effector T cells...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27620276/molecular-pathways-targeting-cd96-and-tigit-for-cancer-immunotherapy
#6
Stephen J Blake, William C Dougall, John J Miles, Michele W L Teng, Mark J Smyth
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96(-)(/)(-) mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. TIGIT overexpression has been shown to reduce NK-cell-mediated cytotoxicity. TIGIT is also upregulated on T cells during cancer and chronic viral infection, with expression associated with effector T-cell exhaustion and increased regulatory T-cell suppression...
September 12, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27551152/mhc-ii-resident-peritoneal-and-pleural-macrophages-rely-on-irf4-for-development-from-circulating-monocytes
#7
Ki-Wook Kim, Jesse W Williams, Ya-Ting Wang, Stoyan Ivanov, Susan Gilfillan, Marco Colonna, Herbert W Virgin, Emmanuel L Gautier, Gwendalyn J Randolph
Peritoneal and pleural resident macrophages in the mouse share common features and in each compartment exist as two distinct subpopulations: F4/80(+) macrophages and MHC II(+) CD11c(+) macrophages. F4/80(+) macrophages derive from embryonic precursors, and their maintenance is controlled by Gata6. However, the origin and regulatory factors that maintain MHC II(+) macrophages remain unknown. Here, we show that the MHC II(+) macrophages arise postnatally from CCR2-dependent precursors that resemble monocytes...
September 19, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27467144/t-helper-cell-activation-and-expansion-is-sensitive-to-glutaminase-inhibition-under-both-hypoxic-and-normoxic-conditions
#8
Zeynep Sener, Fritjof H Cederkvist, Roman Volchenkov, Halvor L Holen, Bjørn S Skålhegg
Immune responses often take place where nutrients and O2 availability are limited. This has an impact on T cell metabolism and influences activation and effector functions. T cell proliferation and expansion are associated with increased consumption of glutamine which is needed in a number of metabolic pathways and regulate various physiological processes. The first step in endogenous glutamine metabolism is reversible and is regulated by glutaminase (GLS1 and GLS2) and glutamine synthase (GLUL). There are two isoforms of GLS1, Kidney type glutaminase (KGA) and Glutaminase C (GAC)...
2016: PloS One
https://www.readbyqxmd.com/read/27440135/investigation-of-the-genetic-overlap-between-rheumatoid-arthritis-and-psoriatic-arthritis-in-a-greek-population
#9
E Myrthianou, M I Zervou, A Budu-Aggrey, E Eliopoulos, D Kardassis, D T Boumpas, N Kougkas, A Barton, P Sidiropoulos, G N Goulielmos
OBJECTIVES: Several rheumatoid arthritis (RA) susceptibility loci have also been found to be associated with psoriatic arthritis (PsA), demonstrating that there is a degree of genetic overlap between various autoimmune diseases. We sought to investigate whether single nucleotide polymorphisms (SNPs) mapping to previously reported RA and/or PsA susceptibility loci, including PLCL2, CCL21, REL, STAT4, CD226, PTPN22, and TYK2, are associated with risk for the two diseases in a genetically homogeneous Greek population...
July 20, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27296670/cd155-on-hiv-infected-cells-is-not-modulated-by-hiv-1-vpu-and-nef-but-synergizes-with-nkg2d-ligands-to-trigger-nk-cell-lysis-of-autologous-primary-hiv-infected-cells
#10
Zachary B Davis, Bharatwaj Sowrirajan, Andrew Cogswell, Jeffrey P Ward, Vicente Planelles, Edward Barker
Activation of primary CD4+ T-cells induces the CD155 but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T-cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on infected T-cells engages DNAM-1. The primary objective of this study is to determine whether CD155 alone or together with NKG2D ligands triggers autologous NK cell lysis of HIV-infected T-cells and whether HIV modulates CD155...
June 13, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27257974/soluble-dnam-1-as-a-predictive-biomarker-for-acute-graft-versus-host-disease
#11
Minoru Kanaya, Kazuko Shibuya, Rei Hirochika, Miyoko Kanemoto, Kazuteru Ohashi, Masafumi Okada, Yukiko Wagatsuma, Yukiko Cho, Hiroshi Kojima, Takanori Teshima, Masahiro Imamura, Hisashi Sakamaki, Akira Shibuya
Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera...
2016: PloS One
https://www.readbyqxmd.com/read/27049654/increased-soluble-cd155-in-the-serum-of-cancer-patients
#12
Akiko Iguchi-Manaka, Genki Okumura, Hiroshi Kojima, Yukiko Cho, Rei Hirochika, Hiroko Bando, Toyomi Sato, Hiroyuki Yoshikawa, Hisato Hara, Akira Shibuya, Kazuko Shibuya
Emerging evidence suggests that DNAM-1 (CD226) play an important role in the recognition of tumor cells and their lysis by cytotoxic T lymphocytes (CTL) and NK cells. Although the DNAM-1 ligand CD155 is ubiquitously expressed in various tissues, many human tumors significantly upregulate the expression of CD155; DNAM-1 on CTL and NK cells may be involved in tumor immunity. However, unlike those in mice, human tissues also express soluble isoforms of CD155 (sCD155) that lack the transmembrane region. Here, we show that sCD155 levels were significantly higher in the sera of 262 patients with lung, gastrointestinal, breast, and gynecologic cancers than in sera from healthy donors...
2016: PloS One
https://www.readbyqxmd.com/read/27034402/sensitivity-of-dendritic-cells-to-nk-mediated-lysis-depends-on-the-inflammatory-environment-and-is-modulated-by-cd54-cd226-driven-interactions
#13
Laura E Smith, Marcin A Olszewski, Anna-Maria Georgoudaki, Arnika K Wagner, Thomas Hägglöf, Mikael C I Karlsson, Margarita Dominguez-Villar, Francisco Garcia-Cozar, Steffan Mueller, Inga Ravens, Günter Bernhardt, Benedict J Chambers
Previous studies have suggested that NK cells may limit T cell responses by their ability to eradicate dendritic cells, as demonstrated by NK cell-mediated killing of dendritic cells generated from mouse bone marrow cells or human monocytes with GM-CSF. In the present study, we demonstrated that conventional dendritic cells, generated in vitro with Flt3 ligand or from spleens, were resistant to NK cell-mediated lysis. However, upon stimulation with GM-CSF, NK cells could mediate lysis of these dendritic cells...
March 31, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/26942885/cd226-ligation-protects-against-eae-by-promoting-il-10-expression-via-regulation-of-cd4-t-cell-differentiation
#14
Rong Zhang, Hanyu Zeng, Yun Zhang, Kun Chen, Chunmei Zhang, Chaojun Song, Liang Fang, Zhuwei Xu, Kun Yang, Boquan Jin, Qintao Wang, Lihua Chen
Treatment targeting CD226 can ameliorate experimental autoimmune encephalomyelitis (EAE), the widely accepted model of MS. However, the mechanisms still need to be elucidated. Here we showed that CD226 blockage by anti-CD226 blocking mAb LeoA1 efficiently promoted IL-10 production in human peripheral blood monocytes (PBMC) or in mixed lymphocyte culture (MLC) system, significantly induced the CD4+IL-10+ T cell differentiation while suppressing the generation of Th1 and Th17. Furthermore, CD226 pAb administration in vivo reduced the onset of EAE in mice by promoting IL-10 production and regulating T cell differentiation...
April 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/26910838/cd226-reduces-endothelial-cell-glucose-uptake-under-hyperglycemic-conditions-with-inflammation-in-type-2-diabetes-mellitus
#15
Yuan Zhang, Tian Liu, Yu Chen, Zilong Dong, Jinxue Zhang, Yizheng Sun, Boquan Jin, Feng Gao, Shuzhong Guo, Ran Zhuang
CD226 is a co-stimulatory adhesion molecule found on immune and endothelial cells. Here, we evaluated a possible role for CD226 in inhibiting glucose uptake in isolated human umbilical vein endothelial cells (HUVECs) and in wild-type (WT) and CD226 knockout (KO) mice with high-fat diet (HFD)-induced type 2 diabetes (T2DM). CD226 expression increased under hyperglycemic conditions in the presence of TNF-α. Furthermore, CD226 knockdown improved glucose uptake in endothelial cells, and CD226 KO mice exhibited increased glucose tolerance...
March 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/26840537/the-role-of-t-cell-costimulation-via-dnam-1-in-kidney-transplantation
#16
Anna K Kraus, Jin Chen, Ilka Edenhofer, Inga Ravens, Ariana Gaspert, Pietro E Cippà, Steffen Mueller, Rudolf P Wuthrich, Stephan Segerer, Guenter Bernhardt, Thomas Fehr
DNAX accessory protein-1 (DNAM-1, CD226) is a co-stimulatory and adhesion molecule expressed mainly by natural killer cells and T cells. DNAM-1 and its two ligands CD112 and CD155 are important in graft-versus-host disease, but their role in solid organ transplantation is largely unknown. We investigated the relevance of this pathway in a mouse kidney transplantation model. CD112 and CD155 are constitutively expressed on renal tubular cells and strongly upregulated in acutely rejected renal allografts. In vitro DNAM-1 blockade during allogeneic priming reduced the allospecific T cell response but not the allospecific cytotoxicity against renal tubular epithelial cells...
2016: PloS One
https://www.readbyqxmd.com/read/26808113/high-density-genotyping-of-immune-related-loci-identifies-new-sle-risk-variants-in-individuals-with-asian-ancestry
#17
Celi Sun, Julio E Molineros, Loren L Looger, Xu-Jie Zhou, Kwangwoo Kim, Yukinori Okada, Jianyang Ma, Yuan-Yuan Qi, Xana Kim-Howard, Prasenjeet Motghare, Krishna Bhattarai, Adam Adler, So-Young Bang, Hye-Soon Lee, Tae-Hwan Kim, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung Cheol Shim, Yuta Kochi, Akari Suzuki, Michiaki Kubo, Takayuki Sumida, Kazuhiko Yamamoto, Shin-Seok Lee, Young Jin Kim, Bok-Ghee Han, Mikhail Dozmorov, Kenneth M Kaufman, Jonathan D Wren, John B Harley, Nan Shen, Kek Heng Chua, Hong Zhang, Sang-Cheol Bae, Swapan K Nath
Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 controls from six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci. We identified ten new loci and confirmed 20 known loci with genome-wide significance. Among the new loci, the most significant locus was GTF2IRD1-GTF2I at 7q11.23 (rs73366469, Pmeta = 3.75 × 10(-117), odds ratio (OR) = 2.38), followed by DEF6, IL12B, TCF7, TERT, CD226, PCNXL3, RASGRP1, SYNGR1 and SIGLEC6...
March 2016: Nature Genetics
https://www.readbyqxmd.com/read/26787820/suppression-of-metastases-using-a-new-lymphocyte-checkpoint-target-for-cancer-immunotherapy
#18
Stephen J Blake, Kimberley Stannard, Jing Liu, Stacey Allen, Michelle C R Yong, Deepak Mittal, Amelia Roman Aguilera, John J Miles, Viviana P Lutzky, Lucas Ferrari de Andrade, Ludovic Martinet, Marco Colonna, Kazuyoshi Takeda, Florian Kühnel, Engin Gurlevik, Günter Bernhardt, Michele W L Teng, Mark J Smyth
UNLABELLED: CD96 has recently been shown as a negative regulator of mouse natural killer (NK)-cell activity, with Cd96(-/-)mice displaying hyperresponsive NK cells upon immune challenge. In this study, we have demonstrated that blocking CD96 with a monoclonal antibody inhibited experimental metastases in three different tumor models. The antimetastatic activity of anti-CD96 was dependent on NK cells, CD226 (DNAM-1), and IFNγ, but independent of activating Fc receptors. Anti-CD96 was more effective in combination with anti-CTLA-4, anti-PD-1, or doxorubicin chemotherapy...
April 2016: Cancer Discovery
https://www.readbyqxmd.com/read/26763445/melanoma-cells-control-antimelanoma-ctl-responses-via-interaction-between-tigit-and-cd155-in-the-effector-phase
#19
Takashi Inozume, Tomonori Yaguchi, Junpei Furuta, Kazutoshi Harada, Yutaka Kawakami, Shinji Shimada
Recently, T-cell immunoreceptor with Ig and ITIM domains (TIGIT) was reported as a candidate for novel immune checkpoints. However, the impact of TIGIT on melanoma-specific cytotoxic T lymphocytes in the effector phase remains unclear. In this study, we demonstrated that melanoma cells control antimelanoma cytotoxic T lymphocyte responses via the TIGIT-CD155 interaction in the effector phase. TIGIT is an inhibitory receptor expressed on T cells, and CD155 is one of the cognate ligands expressed on the tumor cells or antigen-presenting cells...
January 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26689152/cd155-cd226-interaction-impacts-on-the-generation-of-innate-cd8-thymocytes-by-regulating-inkt-cell-differentiation
#20
Hristo Georgiev, Inga Ravens, Akira Shibuya, Reinhold Förster, Günter Bernhardt
The cell surface receptor CD155 influences a variety of immune processes by binding to its ligands CD226, CD96, or TIGIT. Here, we report that the interaction of CD155 with CD226 in the thymus of BALB/c mice has a dual function. It directly influences the dwell time of memory-like CD8(+) T cells, while it is indirectly involved in generating these cells. It was shown earlier that a massive emergence of memory-like CD8 T cells in thymus crucially depends on abundant IL-4, secreted in steady state by iNKT2 (where iNKT is invariant NKT) cells, a subclass of iNKT cells...
April 2016: European Journal of Immunology
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